Disease table of FAMILIAL CANDIDIASIS OMIM ID: PS114580

Gene-disease associations table

GeneAssociated with FAMILIAL CANDIDIASIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IL17FClinVar, OMIM, HUMSAVARHGNC link6p12.21PS114580
STAT1ClinVar, OMIM, HUMSAVARHGNC link2q32.23PS114580, 614892, 613796
CLEC7AClinVar, OMIMHGNC link12p13.22PS114580, 614079
CARD9ClinVar, OMIM, HUMSAVARHGNC link9q34.31PS114580
TRAF3IP2ClinVar, OMIM, HUMSAVARHGNC link6q212PS114580, PS177900
IL17RCOMIMHGNC link3p25.31PS114580
IL17RAClinVar, OMIMHGNC link22q11.11PS114580

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
62IL17F, TRAF3IP2
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
STAT1YES79CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML0
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
STAT1YES7EIF2AK2, PIAS1, NR3C1, CREB5, STAT6, BRCA1, STAT40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
IL17FCLEC7ANo1RHOU
STAT1CARD9No1TSNAX
TRAF3IP2IL17RCYes1TRAF3IP2
TRAF3IP2IL17RAYes5IL17A, SYK, MAP3K7, TRAF6, TRAF3IP2
IL17RCIL17RANo1TRAF3IP2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
IL17FTRAF3IP2No-1IL17RA
IL17FIL17RAYesbinding0
TRAF3IP2IL17RCNo-1IL17A
TRAF3IP2IL17RAYesbinding2IL17A, TRAF6
IL17RCIL17RANo-1IL17A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
IL17FIL17RAYes2IL17F, IL17RA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Tuberculosishsa051525.173CLEC7A, STAT1, CARD9
Inflammatory bowel disease (IBD)hsa053216.432IL17F, STAT1

NET-GE enrichment

Term New enriched termICP valueGenes
Inflammatory bowel disease (IBD) (hsa05321) -6.430.008IL17F, IL17RA, STAT1
Cytokine-cytokine receptor interaction (hsa04060) NEW4.670.036IL17RA, IL17RC, STAT1, TRAF3IP2
Tuberculosis (hsa05152) -5.170.008CLEC7A, STAT1, CARD9
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.373CLEC7A, STAT1, CARD9
C-type lectin receptors (CLRs)R-HSA-56214816.062CLEC7A, CARD9
CLEC7A (Dectin-1) signalingR-HSA-56077646.382CLEC7A, CARD9
Innate Immune SystemR-HSA-1682493.172CLEC7A, CARD9

NET-GE enrichment

Term New enriched termICP valueGenes
C-type lectin receptors (CLRs) (R-HSA-5621481) -6.060.018CLEC7A, CARD9
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (R-HSA-168643) NEW7.310.021STAT1, CARD9
CLEC7A (Dectin-1) signaling (R-HSA-5607764) -6.380.037CLEC7A, CARD9
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
protein binding (GO:0005515) 0.467CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
receptor binding (GO:0005102) 2.436CLEC7A, IL17F, IL17RC, IL17RA, TRAF3IP2, STAT1
signal transducer activity (GO:0004871) 2.284IL17RC, CLEC7A, IL17RA, STAT1
signaling receptor activity (GO:0038023) 2.493IL17RC, CLEC7A, IL17RA
molecular transducer activity (GO:0060089) 2.323IL17RC, CLEC7A, IL17RA
receptor activity (GO:0004872) 2.323IL17RC, CLEC7A, IL17RA
protein dimerization activity (GO:0046983) 2.723IL17F, STAT1, CARD9
identical protein binding (GO:0042802) 2.633IL17F, STAT1, CARD9
protein homodimerization activity (GO:0042803) 3.163IL17F, STAT1, CARD9
cytokine receptor binding (GO:0005126) 4.142IL17F, STAT1
transmembrane signaling receptor activity (GO:0004888) 2.572IL17RC, IL17RA
interleukin-17 receptor activity (GO:0030368) 7.662IL17RC, IL17RA
transmembrane receptor activity (GO:0099600) 2.532IL17RC, IL17RA
cytokine receptor activity (GO:0004896) 5.242IL17RC, IL17RA

NET-GE enrichment

Term New enriched termICP valueGenes
pattern recognition receptor activity (GO:0038187) NEW6.910.013CLEC7A, STAT1
signaling pattern recognition receptor activity (GO:0008329) NEW6.910.013CLEC7A, STAT1
MHC protein binding (GO:0042287) NEW6.180.027CLEC7A, STAT1
cytokine binding (GO:0019955) NEW5.210.01IL17F, IL17RA, STAT1
interleukin-17 receptor activity (GO:0030368) -7.660.0IL17RC, IL17RA
cytokine receptor activity (GO:0004896) -5.240.011IL17RC, IL17RA, STAT1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to stimulus (GO:0050896) 1.227CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of response to stimulus (GO:0048583) 1.547CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of cellular process (GO:0050794) 0.57CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
biological regulation (GO:0065007) 0.397CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
positive regulation of biological process (GO:0048518) 1.27CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of response to stress (GO:0080134) 2.537CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of biological process (GO:0050789) 0.457CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of defense response (GO:0031347) 3.117CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
defense response (GO:0006952) 2.786CLEC7A, IL17F, IL17RC, CARD9, IL17RA, STAT1
cellular process (GO:0009987) 0.266CLEC7A, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
positive regulation of response to stimulus (GO:0048584) 2.186CLEC7A, IL17F, IL17RC, CARD9, IL17RA, TRAF3IP2
immune system process (GO:0002376) 2.296CLEC7A, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
response to stress (GO:0006950) 1.86CLEC7A, IL17F, IL17RC, CARD9, IL17RA, STAT1
signal transduction (GO:0007165) 1.286CLEC7A, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
positive regulation of cellular process (GO:0048522) 1.36IL17F, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
response to biotic stimulus (GO:0009607) 3.095IL17RA, IL17RC, CLEC7A, STAT1, CARD9
response to external biotic stimulus (GO:0043207) 3.135IL17RA, IL17RC, CLEC7A, STAT1, CARD9
response to external stimulus (GO:0009605) 2.555IL17RC, CLEC7A, STAT1, IL17RA, CARD9
positive regulation of defense response (GO:0031349) 3.835IL17RA, IL17F, CLEC7A, IL17RC, CARD9
regulation of multicellular organismal process (GO:0051239) 1.875IL17RA, IL17F, CARD9, IL17RC, STAT1
defense response to other organism (GO:0098542) 3.755IL17RC, CLEC7A, STAT1, IL17RA, CARD9
cell surface receptor signaling pathway (GO:0007166) 2.095IL17RA, IL17RC, CLEC7A, STAT1, CARD9
single-organism cellular process (GO:0044763) 0.655IL17RC, CLEC7A, STAT1, IL17RA, TRAF3IP2
response to other organism (GO:0051707) 3.485IL17RA, IL17RC, CLEC7A, STAT1, CARD9
single-organism process (GO:0044699) 0.485IL17RA, IL17RC, CLEC7A, STAT1, TRAF3IP2
multi-organism process (GO:0051704) 2.655IL17RA, IL17RC, CLEC7A, STAT1, CARD9
regulation of response to external stimulus (GO:0032101) 3.064IL17RA, IL17F, IL17RC, TRAF3IP2
regulation of signal transduction (GO:0009966) 1.844IL17F, STAT1, CARD9, TRAF3IP2
positive regulation of multicellular organismal process (GO:0051240) 2.494IL17RA, IL17F, IL17RC, CARD9
regulation of cytokine production (GO:0001817) 3.44IL17RA, IL17F, IL17RC, CARD9
regulation of immune system process (GO:0002682) 2.54CLEC7A, STAT1, CARD9, TRAF3IP2
regulation of signaling (GO:0023051) 1.724IL17F, STAT1, CARD9, TRAF3IP2
response to chemical (GO:0042221) 1.984IL17RA, CLEC7A, STAT1, CARD9
regulation of cell communication (GO:0010646) 1.734IL17F, STAT1, CARD9, TRAF3IP2
response to organic substance (GO:0010033) 2.24IL17RA, CLEC7A, STAT1, CARD9
positive regulation of cytokine production (GO:0001819) 3.824IL17RA, IL17F, IL17RC, CARD9
positive regulation of metabolic process (GO:0009893) 1.743IL17F, STAT1, CARD9
regulation of secretion (GO:0051046) 3.23IL17RA, IL17F, IL17RC
positive regulation of secretion (GO:0051047) 3.853IL17RA, IL17F, IL17RC
regulation of transport (GO:0051049) 2.243IL17RA, IL17F, IL17RC
positive regulation of cellular metabolic process (GO:0031325) 1.813IL17F, STAT1, CARD9
regulation of cellular metabolic process (GO:0031323) 1.073IL17F, STAT1, CARD9
movement of cell or subcellular component (GO:0006928) 2.613IL17RC, IL17RA, STAT1
regulation of secretion by cell (GO:1903530) 3.283IL17RA, IL17F, IL17RC
positive regulation of secretion by cell (GO:1903532) 3.933IL17RA, IL17F, IL17RC
positive regulation of protein transport (GO:0051222) 3.613IL17RA, IL17F, IL17RC
regulation of protein transport (GO:0051223) 3.123IL17RA, IL17F, IL17RC
intracellular signal transduction (GO:0035556) 2.393STAT1, CARD9, TRAF3IP2
regulation of protein localization (GO:0032880) 2.883IL17RA, IL17F, IL17RC
cellular response to stimulus (GO:0051716) 1.973IL17RA, CLEC7A, STAT1
positive regulation of inflammatory response (GO:0050729) 4.983IL17RA, IL17F, IL17RC
regulation of protein secretion (GO:0050708) 3.773IL17RA, IL17F, IL17RC
regulation of metabolic process (GO:0019222) 1.023IL17F, STAT1, CARD9
regulation of cytokine secretion (GO:0050707) 4.743IL17RA, IL17F, IL17RC
regulation of inflammatory response (GO:0050727) 4.033IL17RA, IL17F, IL17RC
regulation of localization (GO:0032879) 1.943IL17RA, IL17F, IL17RC
regulation of cellular biosynthetic process (GO:0031326) 1.383IL17F, STAT1, CARD9
cell migration (GO:0016477) 3.123IL17RC, IL17RA, STAT1
cytokine-mediated signaling pathway (GO:0019221) 3.63IL17RC, IL17RA, STAT1
regulation of interleukin-6 production (GO:0032675) 5.083IL17RC, IL17F, CARD9
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.273STAT1, CARD9, TRAF3IP2
positive regulation of cytokine production involved in inflammatory response (GO:1900017) 7.533IL17RA, IL17F, IL17RC
regulation of establishment of protein localization (GO:0070201) 3.023IL17RA, IL17F, IL17RC
regulation of innate immune response (GO:0045088) 3.863CLEC7A, STAT1, CARD9
positive regulation of transport (GO:0051050) 2.93IL17RA, IL17F, IL17RC
regulation of macromolecule metabolic process (GO:0060255) 1.083IL17F, STAT1, CARD9
regulation of biosynthetic process (GO:0009889) 1.373IL17F, STAT1, CARD9
immune response (GO:0006955) 2.863CLEC7A, CARD9, TRAF3IP2
positive regulation of establishment of protein localization (GO:1904951) 3.493IL17RA, IL17F, IL17RC
regulation of intracellular signal transduction (GO:1902531) 2.313STAT1, CARD9, TRAF3IP2
regulation of primary metabolic process (GO:0080090) 1.083IL17F, STAT1, CARD9
positive regulation of macromolecule metabolic process (GO:0010604) 1.813IL17F, STAT1, CARD9
locomotion (GO:0040011) 2.913IL17RC, IL17RA, STAT1
regulation of cytokine production involved in inflammatory response (GO:1900015) 6.843IL17RA, IL17F, IL17RC
regulation of immune response (GO:0050776) 2.983CLEC7A, STAT1, CARD9
positive regulation of cytokine secretion (GO:0050715) 5.163IL17RA, IL17F, IL17RC
positive regulation of protein secretion (GO:0050714) 4.393IL17RA, IL17F, IL17RC
response to fungus (GO:0009620) 5.843IL17RC, IL17RA, CARD9
cell motility (GO:0048870) 3.023IL17RC, IL17RA, STAT1
regulation of macromolecule biosynthetic process (GO:0010556) 1.433IL17F, STAT1, CARD9
positive regulation of response to external stimulus (GO:0032103) 4.173IL17RA, IL17F, IL17RC
immune effector process (GO:0002252) 3.583CLEC7A, STAT1, CARD9
positive regulation of interleukin-6 production (GO:0032755) 5.513IL17F, IL17RC, CARD9
regulation of cytokine biosynthetic process (GO:0042035) 5.152IL17F, CARD9
cell chemotaxis (GO:0060326) 4.632IL17RC, IL17RA
taxis (GO:0042330) 4.032IL17RC, IL17RA
response to virus (GO:0009615) 4.212STAT1, CARD9
cellular response to organic substance (GO:0071310) 2.782IL17RA, STAT1
interspecies interaction between organisms (GO:0044419) 3.082STAT1, CARD9
negative regulation of biological process (GO:0048519) 1.332IL17F, STAT1
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 4.542CARD9, TRAF3IP2
leukocyte chemotaxis (GO:0030595) 4.962IL17RC, IL17RA
chemotaxis (GO:0006935) 4.042IL17RC, IL17RA
defense response to fungus (GO:0050832) 6.092IL17RC, IL17RA
regulation of RNA biosynthetic process (GO:2001141) 1.552IL17F, STAT1
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062CLEC7A, CARD9
response to organonitrogen compound (GO:0010243) 3.22STAT1, CARD9
positive regulation of biosynthetic process (GO:0009891) 2.292IL17F, STAT1
positive regulation of immune response (GO:0050778) 3.42CLEC7A, CARD9
regulation of vasculature development (GO:1901342) 4.262IL17F, STAT1
negative regulation of vasculature development (GO:1901343) 5.322IL17F, STAT1
positive regulation of innate immune response (GO:0045089) 4.222CLEC7A, CARD9
regulation of apoptotic process (GO:0042981) 2.52STAT1, CARD9
immune response-regulating signaling pathway (GO:0002764) 3.722CLEC7A, CARD9
regulation of interleukin-6 biosynthetic process (GO:0045408) 6.962IL17F, CARD9
positive regulation of immune system process (GO:0002684) 2.962CLEC7A, CARD9
regulation of anatomical structure morphogenesis (GO:0022603) 2.792IL17F, STAT1
response to cytokine (GO:0034097) 3.842IL17RA, STAT1
regulation of developmental process (GO:0050793) 2.12IL17F, STAT1
regulation of viral process (GO:0050792) 3.892STAT1, TRAF3IP2
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 3.822STAT1, TRAF3IP2
regulation of multi-organism process (GO:0043900) 3.62STAT1, TRAF3IP2
metabolic process (GO:0008152) 0.582IL17F, STAT1
positive regulation of intracellular signal transduction (GO:1902533) 2.952CARD9, TRAF3IP2
immune response-activating signal transduction (GO:0002757) 3.82CLEC7A, CARD9
defense response to virus (GO:0051607) 4.632STAT1, CARD9
programmed cell death (GO:0012501) 3.12STAT1, TRAF3IP2
cellular response to cytokine stimulus (GO:0071345) 4.332IL17RA, STAT1
myeloid leukocyte migration (GO:0097529) 5.132IL17RC, IL17RA
response to nitrogen compound (GO:1901698) 3.122STAT1, CARD9
innate immune response-activating signal transduction (GO:0002758) 4.452CLEC7A, CARD9
cell activation (GO:0001775) 3.472IL17RA, CLEC7A
regulation of transcription, DNA-templated (GO:0006355) 1.562IL17F, STAT1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392IL17F, STAT1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242IL17F, STAT1
positive regulation of signal transduction (GO:0009967) 2.52CARD9, TRAF3IP2
inflammatory response (GO:0006954) 3.642IL17F, CLEC7A
positive regulation of signaling (GO:0023056) 2.412CARD9, TRAF3IP2
cellular response to chemical stimulus (GO:0070887) 2.572IL17RA, STAT1
positive regulation of cell communication (GO:0010647) 2.412CARD9, TRAF3IP2
response to organic cyclic compound (GO:0014070) 3.072STAT1, CARD9
response to endogenous stimulus (GO:0009719) 2.792STAT1, CARD9
regulation of interleukin-2 biosynthetic process (GO:0045076) 6.842IL17F, CARD9
negative regulation of multicellular organismal process (GO:0051241) 2.842IL17F, STAT1
regulation of protein metabolic process (GO:0051246) 1.932IL17F, CARD9
granulocyte migration (GO:0097530) 5.412IL17RC, IL17RA
innate immune response activating cell surface receptor signaling pathway (GO:0002220) 5.072CLEC7A, CARD9
stimulatory C-type lectin receptor signaling pathway (GO:0002223) 5.092CLEC7A, CARD9
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562IL17F, STAT1
regulation of nucleic acid-templated transcription (GO:1903506) 1.552IL17F, STAT1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562IL17F, STAT1
negative regulation of developmental process (GO:0051093) 3.172IL17F, STAT1
regulation of RNA metabolic process (GO:0051252) 1.522IL17F, STAT1
positive regulation of RNA metabolic process (GO:0051254) 2.512IL17F, STAT1
macromolecule metabolic process (GO:0043170) 0.832IL17F, STAT1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542IL17F, STAT1
positive regulation of gene expression (GO:0010628) 2.352IL17F, STAT1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812IL17F, STAT1
positive regulation of interleukin-6 secretion (GO:2000778) 6.962IL17F, IL17RC
regulation of interleukin-2 production (GO:0032663) 5.862IL17F, CARD9
negative regulation of angiogenesis (GO:0016525) 5.422IL17F, STAT1
developmental process (GO:0032502) 1.362IL17F, STAT1
negative regulation of blood vessel morphogenesis (GO:2000181) 5.382IL17F, STAT1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32IL17F, STAT1
leukocyte migration (GO:0050900) 4.192IL17RC, IL17RA
cell death (GO:0008219) 3.052STAT1, TRAF3IP2
regulation of cell death (GO:0010941) 2.432STAT1, CARD9
activation of innate immune response (GO:0002218) 4.412CLEC7A, CARD9
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462IL17F, STAT1
regulation of angiogenesis (GO:0045765) 4.362IL17F, STAT1
organic substance metabolic process (GO:0071704) 0.632IL17F, STAT1
regulation of programmed cell death (GO:0043067) 2.492STAT1, CARD9
regulation of multicellular organismal development (GO:2000026) 2.312IL17F, STAT1
granulocyte chemotaxis (GO:0071621) 5.482IL17RC, IL17RA
regulation of gene expression (GO:0010468) 1.372IL17F, STAT1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352IL17F, STAT1
viral process (GO:0016032) 3.152STAT1, CARD9
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432IL17F, STAT1
innate immune response (GO:0045087) 3.552CLEC7A, CARD9
apoptotic process (GO:0006915) 3.142STAT1, TRAF3IP2
biosynthetic process (GO:0009058) 1.322IL17F, STAT1
multi-organism cellular process (GO:0044764) 3.142STAT1, CARD9
regulation of nitrogen compound metabolic process (GO:0051171) 1.362IL17F, STAT1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292IL17F, STAT1
response to oxygen-containing compound (GO:1901700) 2.572STAT1, CARD9
primary metabolic process (GO:0044238) 0.692IL17F, STAT1
anatomical structure development (GO:0048856) 1.582IL17F, STAT1
response to peptide (GO:1901652) 3.942STAT1, CARD9
activation of immune response (GO:0002253) 3.672CLEC7A, CARD9
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962CLEC7A, CARD9
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152STAT1, CARD9

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) NEW7.020.027IL17F, IL17RA
regulation of response to stimulus (GO:0048583) -1.540.001CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of cytokine biosynthetic process (GO:0042035) -5.150.003IL17F, STAT1, IL17RA, CARD9
regulation of granulocyte macrophage colony-stimulating factor biosynthetic process (GO:0045423) NEW8.340.003IL17F, IL17RA
regulation of defense response (GO:0031347) -3.110.0CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of interleukin-6 biosynthetic process (GO:0045408) -6.960.001IL17F, IL17RA, CARD9
positive regulation of multicellular organismal process (GO:0051240) -2.490.011IL17F, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
regulation of inflammatory response (GO:0050727) -4.030.002IL17RA, IL17F, STAT1, IL17RC, TRAF3IP2
positive regulation of biological process (GO:0048518) -1.20.018CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of response to wounding (GO:1903034) NEW4.740.017IL17RA, IL17F, STAT1, IL17RC, TRAF3IP2
regulation of interleukin-6 production (GO:0032675) -5.080.002IL17F, CARD9, IL17RA, STAT1
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) -4.270.019STAT1, CARD9, TRAF3IP2
regulation of interleukin-8 production (GO:0032677) NEW5.620.031IL17F, IL17RA, STAT1
regulation of innate immune response (GO:0045088) -3.860.031CLEC7A, STAT1, CARD9
positive regulation of cytokine production involved in inflammatory response (GO:1900017) -7.530.0IL17RA, IL17F, IL17RC
regulation of cytokine production involved in inflammatory response (GO:1900015) -6.840.0IL17RA, IL17F, IL17RC
regulation of response to stress (GO:0080134) -2.530.002CLEC7A, IL17F, IL17RA, CARD9, IL17RC, TRAF3IP2, STAT1
regulation of cytokine production (GO:0001817) -3.40.006IL17F, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
response to exogenous dsRNA (GO:0043330) NEW5.920.039STAT1, CARD9
regulation of interleukin-2 production (GO:0032663) -5.860.01IL17F, IL17RA, CARD9
regulation of interleukin-2 biosynthetic process (GO:0045076) -6.840.008IL17F, IL17RA, CARD9
positive regulation of cytokine production (GO:0001819) -3.820.0IL17F, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.116CLEC7A, IL17RC, CARD9, IL17RA, TRAF3IP2, STAT1
membrane (GO:0016020) 0.684IL17RC, CLEC7A, IL17RA, CARD9
plasma membrane (GO:0005886) 1.394IL17RC, CLEC7A, IL17RA, CARD9
cytoplasm (GO:0005737) 1.013CLEC7A, STAT1, CARD9
intracellular part (GO:0044424) 0.283CLEC7A, STAT1, CARD9
integral component of membrane (GO:0016021) 1.143IL17RC, CLEC7A, IL17RA
intrinsic component of membrane (GO:0031224) 1.133IL17RC, CLEC7A, IL17RA
membrane part (GO:0044425) 0.953IL17RC, CLEC7A, IL17RA
intracellular organelle part (GO:0044446) 0.812CLEC7A, STAT1
intracellular membrane-bounded organelle (GO:0043231) 0.62CLEC7A, STAT1
plasma membrane part (GO:0044459) 1.952IL17RC, IL17RA
membrane-bounded organelle (GO:0043227) 0.472CLEC7A, STAT1
cytosol (GO:0005829) 1.682STAT1, CARD9
cytoplasmic part (GO:0044444) 0.822STAT1, CARD9
intracellular (GO:0005622) 2.372CARD9, TRAF3IP2
nucleoplasm (GO:0005654) 1.892CLEC7A, STAT1
intracellular organelle (GO:0043229) 0.512CLEC7A, STAT1
extracellular region (GO:0005576) 2.182IL17F, IL17RA
nuclear part (GO:0044428) 1.552CLEC7A, STAT1
integral component of plasma membrane (GO:0005887) 2.572IL17RC, IL17RA
intrinsic component of plasma membrane (GO:0031226) 2.532IL17RC, IL17RA
organelle (GO:0043226) 0.42CLEC7A, STAT1
organelle part (GO:0044422) 0.792CLEC7A, STAT1