| Disease ID | Disease name | Source of annotation with HLA-C | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 609423 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO | OMIM | link to OMIM | 16 | HLA-C, IFNG, CCL3, CD209, IL4R, KIR3DL1, CCL2, TLR3, CCR2, CX3CR1, CCL11, CCR5, CXCL12, CCL3L1, CXCR1, IL10 |
| PS177900 | PSORIASIS | ClinVar, OMIM | link to OMIM | 6 | HLA-C, TRAF3IP2, AP1S3, IL23R, IL36RN, CARD14 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Antigen processing and presentation | hsa04612 | 6.04 |
| Natural killer cell mediated cytotoxicity | hsa04650 | 5.53 |
| Autoimmune thyroid disease | hsa05320 | 6.62 |
| Allograft rejection | hsa05330 | 6.91 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| Graft-versus-host disease | hsa05332 | 6.84 |
| Cell adhesion molecules (CAMs) | hsa04514 | 5.36 |
| Phagosome | hsa04145 | 5.27 |
| Endocytosis | hsa04144 | 4.92 |
| Type I diabetes mellitus | hsa04940 | 6.79 |
| HTLV-I infection | hsa05166 | 4.59 |
| Epstein-Barr virus infection | hsa05169 | 4.97 |
| Viral myocarditis | hsa05416 | 6.45 |
| Herpes simplex infection | hsa05168 | 5.08 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Antigen processing-Cross presentation | R-HSA-1236975 | 5.88 |
| Immune System | R-HSA-168256 | 2.37 |
| ER-Phagosome pathway | R-HSA-1236974 | 6.08 |
| Endosomal/Vacuolar pathway | R-HSA-1236977 | 6.92 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| Interferon Signaling | R-HSA-913531 | 4.95 |
| Class I MHC mediated antigen processing & presentation | R-HSA-983169 | 4.65 |
| DAP12 interactions | R-HSA-2172127 | 4.56 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Interferon gamma signaling | R-HSA-877300 | 5.67 |
| Interferon alpha/beta signaling | R-HSA-909733 | 6.04 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | R-HSA-983170 | 6.64 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | R-HSA-198933 | 4.7 |
| GO term | GO ID | GO IC |
|---|---|---|
| signaling receptor activity | GO:0038023 | 2.49 |
| antigen binding | GO:0003823 | 5.02 |
| MHC class II receptor activity | GO:0032395 | 7.1 |
| peptide antigen binding | GO:0042605 | 6.18 |
| amide binding | GO:0033218 | 4.14 |
| signal transducer activity | GO:0004871 | 2.28 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| TAP binding | GO:0046977 | 7.79 |
| peptide binding | GO:0042277 | 4.22 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| receptor activity | GO:0004872 | 2.32 |