Disease table of HYPERBILIRUBINEMIA OMIM ID: PS237450

Gene-disease associations table

GeneAssociated with HYPERBILIRUBINEMIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SLCO1B1ClinVar, OMIMHGNC link12p12.11PS237450
UGT1A4ClinVar, HUMSAVARHGNC link2q37.11PS237450
SLCO1B3ClinVar, OMIMHGNC link12p12.21PS237450
UGT1A1ClinVar, OMIM, HUMSAVARHGNC link2q37.12601816, PS237450
ABCC2ClinVar, OMIM, HUMSAVARHGNC link10q24.21PS237450

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 5662SLCO1B1, SLCO1B3
Group 1522UGT1A1, UGT1A4
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
2q37.12UGT1A1, UGT1A4
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
2q372UGT1A1, UGT1A4
12p122SLCO1B1, SLCO1B3
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
12p12SLCO1B1, SLCO1B3
2q32UGT1A1, UGT1A4
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
12p2SLCO1B1, SLCO1B3
2q2UGT1A1, UGT1A4
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
22UGT1A1, UGT1A4
122SLCO1B1, SLCO1B3
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
HNF1ANO26GPR39, FABP1, CYP1A2, NT5E, SLC22A9, ALB, SLCO1B3, UGT2B7, UGT2B17, SLC22A10, APOM, CDH17, IGFBP1, TM4SF1, CRP, UGT1A1, UGT1A8, LCT, UGT1A7, AKR1C4, UGT1A10, ACAT2, UGT1A9, AFP, CSRP1, MTTP2SLCO1B3, UGT1A1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
UGT1A4YES2SP1, ESR10
SLCO1B3YES3HNF1A, FOXA2, NR1H40
UGT1A1YES5NR1I2, AHR, HNF1A, NR1I3, NR3C10
ABCC2YES1IRF30
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SLCO1B1SLCO1B3No-1ALB
SLCO1B1UGT1A1No-1NR1I2
SLCO1B1ABCC2No-1NR1I2
UGT1A1ABCC2No-1NR1I2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Bile secretionhsa049766.563SLCO1B1, SLCO1B3, ABCC2
Metabolism of xenobiotics by cytochrome P450hsa009806.482UGT1A4, UGT1A1
Porphyrin and chlorophyll metabolismhsa008607.412UGT1A4, UGT1A1
Drug metabolism - cytochrome P450hsa009826.62UGT1A4, UGT1A1
Drug metabolism - other enzymeshsa009837.212UGT1A4, UGT1A1
Metabolic pathwayshsa011002.492UGT1A4, UGT1A1
Steroid hormone biosynthesishsa001406.932UGT1A4, UGT1A1
Ascorbate and aldarate metabolismhsa000538.072UGT1A4, UGT1A1
Starch and sucrose metabolismhsa005006.912UGT1A4, UGT1A1
Retinol metabolismhsa008306.792UGT1A4, UGT1A1
Chemical carcinogenesishsa052046.362UGT1A4, UGT1A1
Pentose and glucuronate interconversionshsa000407.682UGT1A4, UGT1A1

NET-GE enrichment

Term New enriched termICP valueGenes
Metabolism of xenobiotics by cytochrome P450 (hsa00980) -6.480.031UGT1A4, UGT1A1
Porphyrin and chlorophyll metabolism (hsa00860) -7.410.013UGT1A4, UGT1A1
Drug metabolism - cytochrome P450 (hsa00982) -6.60.048UGT1A4, UGT1A1
Bile secretion (hsa04976) -6.560.0SLCO1B1, SLCO1B3, ABCC2
Retinol metabolism (hsa00830) -6.790.021UGT1A4, UGT1A1
Drug metabolism - other enzymes (hsa00983) -7.210.019UGT1A4, UGT1A1
Steroid hormone biosynthesis (hsa00140) -6.930.017SLCO1B1, UGT1A4, UGT1A1
Digestive systemNEW4.120.045SLCO1B1, SLCO1B3, ABCC2
Ascorbate and aldarate metabolism (hsa00053) -8.070.003UGT1A4, UGT1A1
Starch and sucrose metabolism (hsa00500) -6.910.017UGT1A4, UGT1A1
Chemical carcinogenesis (hsa05204) -6.360.037UGT1A4, UGT1A1
Pentose and glucuronate interconversions (hsa00040) -7.680.006UGT1A4, UGT1A1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.344UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
Transmembrane transport of small moleculesR-HSA-3825513.793SLCO1B1, SLCO1B3, ABCC2
Bile acid and bile salt metabolismR-HSA-1940687.852SLCO1B1, SLCO1B3
GlucuronidationR-HSA-1565888.732UGT1A4, UGT1A1
Biological oxidationsR-HSA-2118595.552UGT1A4, UGT1A1
Transport of organic anionsR-HSA-8795189.522SLCO1B1, SLCO1B3
Phase II conjugationR-HSA-1565806.522UGT1A4, UGT1A1
Diseases of metabolismR-HSA-56689146.572UGT1A4, UGT1A1
SLC-mediated transmembrane transportR-HSA-4254074.952SLCO1B1, SLCO1B3
DiseaseR-HSA-16436853.332UGT1A4, UGT1A1
Metabolism of porphyrinsR-HSA-1894458.892UGT1A4, UGT1A1
Metabolism of lipids and lipoproteinsR-HSA-5568333.792SLCO1B1, SLCO1B3
Transport of vitamins, nucleosides, and related moleculesR-HSA-4253977.732SLCO1B1, SLCO1B3
Recycling of bile acids and saltsR-HSA-1594189.082SLCO1B1, SLCO1B3
Heme degradationR-HSA-18948310.42UGT1A4, UGT1A1
Metabolic disorders of biological oxidation enzymesR-HSA-55790297.852UGT1A4, UGT1A1

NET-GE enrichment

Term New enriched termICP valueGenes
Bile acid and bile salt metabolism (R-HSA-194068) -7.850.011SLCO1B1, SLCO1B3
Glucuronidation (R-HSA-156588) -8.730.001UGT1A4, UGT1A1
Biological oxidations (R-HSA-211859) -5.550.009SLCO1B1, UGT1A4, UGT1A1
Transport of organic anions (R-HSA-879518) -9.520.0SLCO1B1, SLCO1B3
Recycling of bile acids and salts (R-HSA-159418) -9.080.001SLCO1B1, SLCO1B3
Phase II conjugation (R-HSA-156580) -6.520.023UGT1A4, UGT1A1
Diseases of metabolism (R-HSA-5668914) -6.570.021UGT1A4, UGT1A1
Metabolism of porphyrins (R-HSA-189445) -8.890.001UGT1A4, UGT1A1
SLC-mediated transmembrane transport (R-HSA-425407) -4.950.026SLCO1B1, SLCO1B3, ABCC2
Transport of vitamins, nucleosides, and related molecules (R-HSA-425397) -7.730.007SLCO1B1, SLCO1B3
Heme degradation (R-HSA-189483) -10.40.0UGT1A4, UGT1A1
Metabolic disorders of biological oxidation enzymes (R-HSA-5579029) -7.850.004UGT1A4, UGT1A1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
substrate-specific transmembrane transporter activity (GO:0022891) 2.93SLCO1B1, SLCO1B3, ABCC2
substrate-specific transporter activity (GO:0022892) 2.723SLCO1B1, SLCO1B3, ABCC2
organic acid transmembrane transporter activity (GO:0005342) 4.973SLCO1B1, SLCO1B3, ABCC2
organic anion transmembrane transporter activity (GO:0008514) 5.313SLCO1B1, SLCO1B3, ABCC2
transporter activity (GO:0005215) 2.573SLCO1B1, SLCO1B3, ABCC2
anion transmembrane transporter activity (GO:0008509) 4.433SLCO1B1, SLCO1B3, ABCC2
ion transmembrane transporter activity (GO:0015075) 3.043SLCO1B1, SLCO1B3, ABCC2
catalytic activity (GO:0003824) 1.053UGT1A4, ABCC2, UGT1A1
transmembrane transporter activity (GO:0022857) 2.823SLCO1B1, SLCO1B3, ABCC2
binding (GO:0005488) 0.183UGT1A4, ABCC2, UGT1A1
protein binding (GO:0005515) 0.463UGT1A4, ABCC2, UGT1A1
carboxylic acid transmembrane transporter activity (GO:0046943) 4.993SLCO1B1, SLCO1B3, ABCC2
active transmembrane transporter activity (GO:0022804) 3.853SLCO1B1, SLCO1B3, ABCC2
monocarboxylic acid transmembrane transporter activity (GO:0008028) 6.182SLCO1B1, SLCO1B3
isoprenoid binding (GO:0019840) 6.052UGT1A4, UGT1A1
enzyme binding (GO:0019899) 2.272UGT1A4, UGT1A1
anion binding (GO:0043168) 4.172UGT1A4, UGT1A1
bile acid transmembrane transporter activity (GO:0015125) 7.032SLCO1B1, SLCO1B3
ion binding (GO:0043167) 1.362UGT1A4, UGT1A1
transferase activity (GO:0016740) 1.952UGT1A4, UGT1A1
sodium-independent organic anion transmembrane transporter activity (GO:0015347) 6.692SLCO1B1, SLCO1B3
glucuronosyltransferase activity (GO:0015020) 6.272UGT1A4, UGT1A1
retinoid binding (GO:0005501) 6.12UGT1A4, UGT1A1
identical protein binding (GO:0042802) 2.632UGT1A4, UGT1A1
protein homodimerization activity (GO:0042803) 3.162UGT1A4, UGT1A1
lipid transporter activity (GO:0005319) 5.032SLCO1B1, SLCO1B3
secondary active transmembrane transporter activity (GO:0015291) 4.292SLCO1B1, SLCO1B3
lipid binding (GO:0008289) 3.262UGT1A4, UGT1A1
monocarboxylic acid binding (GO:0033293) 5.612UGT1A4, UGT1A1
UDP-glycosyltransferase activity (GO:0008194) 4.812UGT1A4, UGT1A1
organic cyclic compound binding (GO:0097159) 1.052ABCC2, UGT1A1
carboxylic acid binding (GO:0031406) 4.642UGT1A4, UGT1A1
organic hydroxy compound transmembrane transporter activity (GO:1901618) 6.022SLCO1B1, SLCO1B3
transferase activity, transferring glycosyl groups (GO:0016757) 4.082UGT1A4, UGT1A1
retinoic acid binding (GO:0001972) 6.62UGT1A4, UGT1A1
transferase activity, transferring hexosyl groups (GO:0016758) 4.432UGT1A4, UGT1A1
protein dimerization activity (GO:0046983) 2.722UGT1A4, UGT1A1
protein heterodimerization activity (GO:0046982) 3.642UGT1A4, UGT1A1

NET-GE enrichment

Term New enriched termICP valueGenes
organic anion transmembrane transporter activity (GO:0008514) -5.310.0SLCO1B1, SLCO1B3, ABCC2
glucuronosyltransferase activity (GO:0015020) -6.270.004UGT1A4, UGT1A1
UDP-glycosyltransferase activity (GO:0008194) -4.810.036UGT1A4, UGT1A1
anion transmembrane transporter activity (GO:0008509) -4.430.002SLCO1B1, SLCO1B3, ABCC2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.265UGT1A4, SLCO1B3, ABCC2, SLCO1B1, UGT1A1
single-organism cellular process (GO:0044763) 0.655SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
single-organism process (GO:0044699) 0.485SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
single-organism metabolic process (GO:0044710) 1.634UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
organic acid metabolic process (GO:0006082) 3.014UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
cellular metabolic process (GO:0044237) 0.694UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
carboxylic acid metabolic process (GO:0019752) 3.124SLCO1B1, SLCO1B3, UGT1A4, UGT1A1
monocarboxylic acid metabolic process (GO:0032787) 3.574UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
organic substance metabolic process (GO:0071704) 0.634UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
biological regulation (GO:0065007) 0.394SLCO1B1, ABCC2, UGT1A4, UGT1A1
small molecule metabolic process (GO:0044281) 2.384SLCO1B1, SLCO1B3, UGT1A4, UGT1A1
metabolic process (GO:0008152) 0.584UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
oxoacid metabolic process (GO:0043436) 3.124UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
organic cyclic compound metabolic process (GO:1901360) 1.264UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
primary metabolic process (GO:0044238) 0.693SLCO1B1, SLCO1B3, UGT1A1
establishment of localization (GO:0051234) 1.483SLCO1B1, SLCO1B3, ABCC2
monocarboxylic acid transport (GO:0015718) 5.073SLCO1B1, SLCO1B3, ABCC2
lipid metabolic process (GO:0006629) 2.683SLCO1B1, SLCO1B3, UGT1A1
lipid transport (GO:0006869) 4.243SLCO1B1, SLCO1B3, ABCC2
ion transport (GO:0006811) 2.663SLCO1B1, SLCO1B3, ABCC2
transport (GO:0006810) 1.513SLCO1B1, SLCO1B3, ABCC2
organic anion transport (GO:0015711) 4.073SLCO1B1, SLCO1B3, ABCC2
regulation of hormone levels (GO:0010817) 3.563SLCO1B1, ABCC2, UGT1A1
single-organism transport (GO:0044765) 2.183SLCO1B1, SLCO1B3, ABCC2
anion transport (GO:0006820) 3.713SLCO1B1, SLCO1B3, ABCC2
single-organism localization (GO:1902578) 2.093SLCO1B1, SLCO1B3, ABCC2
organic substance transport (GO:0071702) 2.153SLCO1B1, SLCO1B3, ABCC2
regulation of biological quality (GO:0065008) 1.683SLCO1B1, ABCC2, UGT1A1
localization (GO:0051179) 1.43SLCO1B1, SLCO1B3, ABCC2
steroid metabolic process (GO:0008202) 4.323SLCO1B1, SLCO1B3, UGT1A1
carboxylic acid transport (GO:0046942) 4.283SLCO1B1, SLCO1B3, ABCC2
negative regulation of fatty acid metabolic process (GO:0045922) 6.332UGT1A4, UGT1A1
glucuronate metabolic process (GO:0019585) 6.432UGT1A4, UGT1A1
negative regulation of metabolic process (GO:0009892) 1.932UGT1A4, UGT1A1
regulation of primary metabolic process (GO:0080090) 1.082UGT1A4, UGT1A1
regulation of metabolic process (GO:0019222) 1.022UGT1A4, UGT1A1
organic hydroxy compound transport (GO:0015850) 4.962SLCO1B1, SLCO1B3
bile acid and bile salt transport (GO:0015721) 6.362SLCO1B1, SLCO1B3
heme metabolic process (GO:0042168) 6.332UGT1A4, UGT1A1
negative regulation of cellular carbohydrate metabolic process (GO:0010677) 5.882UGT1A4, UGT1A1
negative regulation of cellular metabolic process (GO:0031324) 2.012UGT1A4, UGT1A1
response to lipid (GO:0033993) 3.112ABCC2, UGT1A1
porphyrin-containing compound metabolic process (GO:0006778) 6.092UGT1A4, UGT1A1
cellular catabolic process (GO:0044248) 2.622UGT1A4, UGT1A1
xenobiotic metabolic process (GO:0006805) 5.192UGT1A4, UGT1A1
cellular nitrogen compound metabolic process (GO:0034641) 1.222UGT1A4, UGT1A1
nitrogen compound metabolic process (GO:0006807) 1.132UGT1A4, UGT1A1
modified amino acid transport (GO:0072337) 6.512SLCO1B1, ABCC2
catabolic process (GO:0009056) 2.382UGT1A4, UGT1A1
negative regulation of cellular process (GO:0048523) 1.412UGT1A4, UGT1A1
negative regulation of cellular glucuronidation (GO:2001030) 7.652UGT1A4, UGT1A1
regulation of biological process (GO:0050789) 0.452UGT1A4, UGT1A1
response to organic cyclic compound (GO:0014070) 3.072ABCC2, UGT1A1
organic cyclic compound catabolic process (GO:1901361) 3.732UGT1A4, UGT1A1
single-organism catabolic process (GO:0044712) 3.212UGT1A4, UGT1A1
organic substance biosynthetic process (GO:1901576) 1.342UGT1A4, UGT1A1
bilirubin conjugation (GO:0006789) 9.042UGT1A4, UGT1A1
cofactor metabolic process (GO:0051186) 3.912UGT1A4, UGT1A1
pigment metabolic process (GO:0042440) 5.592UGT1A4, UGT1A1
flavonoid glucuronidation (GO:0052696) 6.682UGT1A4, UGT1A1
pigment catabolic process (GO:0046149) 7.782UGT1A4, UGT1A1
response to drug (GO:0042493) 3.712ABCC2, UGT1A1
negative regulation of transferase activity (GO:0051348) 3.872UGT1A4, UGT1A1
porphyrin-containing compound catabolic process (GO:0006787) 7.782UGT1A4, UGT1A1
regulation of cellular ketone metabolic process (GO:0010565) 4.672UGT1A4, UGT1A1
negative regulation of catalytic activity (GO:0043086) 3.02UGT1A4, UGT1A1
nitrogen compound transport (GO:0071705) 3.542SLCO1B1, ABCC2
tetrapyrrole catabolic process (GO:0033015) 7.782UGT1A4, UGT1A1
negative regulation of lipid metabolic process (GO:0045833) 5.332UGT1A4, UGT1A1
tetrapyrrole metabolic process (GO:0033013) 5.652UGT1A4, UGT1A1
negative regulation of molecular function (GO:0044092) 2.742UGT1A4, UGT1A1
negative regulation of carbohydrate metabolic process (GO:0045912) 5.762UGT1A4, UGT1A1
regulation of molecular function (GO:0065009) 1.782UGT1A4, UGT1A1
xenobiotic glucuronidation (GO:0052697) 7.532UGT1A4, UGT1A1
response to endogenous stimulus (GO:0009719) 2.792ABCC2, UGT1A1
cellular nitrogen compound catabolic process (GO:0044270) 3.82UGT1A4, UGT1A1
biosynthetic process (GO:0009058) 1.322UGT1A4, UGT1A1
regulation of lipid metabolic process (GO:0019216) 4.082UGT1A4, UGT1A1
regulation of fatty acid metabolic process (GO:0019217) 5.252UGT1A4, UGT1A1
organic acid transport (GO:0015849) 4.932SLCO1B1, SLCO1B3
regulation of catalytic activity (GO:0050790) 1.972UGT1A4, UGT1A1
cellular aromatic compound metabolic process (GO:0006725) 1.32UGT1A4, UGT1A1
organic substance catabolic process (GO:1901575) 2.452UGT1A4, UGT1A1
thyroid hormone transport (GO:0070327) 7.532SLCO1B1, ABCC2
regulation of cellular process (GO:0050794) 0.52UGT1A4, UGT1A1
regulation of cellular glucuronidation (GO:2001029) 7.532UGT1A4, UGT1A1
response to stress (GO:0006950) 1.82ABCC2, UGT1A1
cellular glucuronidation (GO:0052695) 6.642UGT1A4, UGT1A1
regulation of cellular carbohydrate metabolic process (GO:0010675) 4.812UGT1A4, UGT1A1
negative regulation of biological process (GO:0048519) 1.332UGT1A4, UGT1A1
response to chemical (GO:0042221) 1.982ABCC2, UGT1A1
bile acid metabolic process (GO:0008206) 6.152SLCO1B1, SLCO1B3
heterocycle catabolic process (GO:0046700) 3.822UGT1A4, UGT1A1
sodium-independent organic anion transport (GO:0043252) 6.592SLCO1B1, SLCO1B3
response to organic substance (GO:0010033) 2.22ABCC2, UGT1A1
heterocycle metabolic process (GO:0046483) 1.312UGT1A4, UGT1A1
response to oxygen-containing compound (GO:1901700) 2.572ABCC2, UGT1A1
drug metabolic process (GO:0017144) 6.042UGT1A4, UGT1A1
organonitrogen compound metabolic process (GO:1901564) 2.322UGT1A4, UGT1A1
organonitrogen compound catabolic process (GO:1901565) 3.912UGT1A4, UGT1A1
heme catabolic process (GO:0042167) 7.782UGT1A4, UGT1A1
regulation of carbohydrate metabolic process (GO:0006109) 4.572UGT1A4, UGT1A1
response to stimulus (GO:0050896) 1.222ABCC2, UGT1A1
flavonoid metabolic process (GO:0009812) 6.42UGT1A4, UGT1A1
flavonoid biosynthetic process (GO:0009813) 6.782UGT1A4, UGT1A1
regulation of transferase activity (GO:0051338) 2.882UGT1A4, UGT1A1
hormone transport (GO:0009914) 5.332SLCO1B1, ABCC2
regulation of cellular metabolic process (GO:0031323) 1.072UGT1A4, UGT1A1
uronic acid metabolic process (GO:0006063) 6.432UGT1A4, UGT1A1
cofactor catabolic process (GO:0051187) 6.782UGT1A4, UGT1A1
response to hormone (GO:0009725) 3.332ABCC2, UGT1A1
aromatic compound catabolic process (GO:0019439) 3.792UGT1A4, UGT1A1
regulation of glucuronosyltransferase activity (GO:1904223) 7.652UGT1A4, UGT1A1
negative regulation of glucuronosyltransferase activity (GO:1904224) 7.652UGT1A4, UGT1A1
response to steroid hormone (GO:0048545) 4.242ABCC2, UGT1A1

NET-GE enrichment

Term New enriched termICP valueGenes
glucuronate metabolic process (GO:0019585) -6.430.002UGT1A4, UGT1A1
monocarboxylic acid transport (GO:0015718) -5.070.0SLCO1B1, SLCO1B3, ABCC2
cellular glucuronidation (GO:0052695) -6.640.002UGT1A4, UGT1A1
organic acid metabolic process (GO:0006082) -3.010.012UGT1A4, SLCO1B3, ABCC2, SLCO1B1, UGT1A1
bile acid and bile salt transport (GO:0015721) -6.360.018SLCO1B1, SLCO1B3
organic acid transport (GO:0015849) -4.930.004SLCO1B1, SLCO1B3, ABCC2
organic anion transport (GO:0015711) -4.070.014SLCO1B1, SLCO1B3, ABCC2
carboxylic acid metabolic process (GO:0019752) -3.120.01SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
monocarboxylic acid metabolic process (GO:0032787) -3.570.001UGT1A4, SLCO1B3, SLCO1B1, UGT1A1
xenobiotic metabolic process (GO:0006805) -5.190.018SLCO1B1, UGT1A4, UGT1A1
anion transport (GO:0006820) -3.710.036SLCO1B1, SLCO1B3, ABCC2
small molecule metabolic process (GO:0044281) -2.380.019SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
uronic acid metabolic process (GO:0006063) -6.430.002UGT1A4, UGT1A1
oxoacid metabolic process (GO:0043436) -3.120.016UGT1A4, SLCO1B3, ABCC2, SLCO1B1, UGT1A1
bile acid metabolic process (GO:0008206) -6.150.01SLCO1B1, SLCO1B3
sodium-independent organic anion transport (GO:0043252) -6.590.001SLCO1B1, SLCO1B3
steroid metabolic process (GO:0008202) -4.320.005SLCO1B1, SLCO1B3, UGT1A1
carboxylic acid transport (GO:0046942) -4.280.004SLCO1B1, SLCO1B3, ABCC2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane part (GO:0044425) 0.955UGT1A4, SLCO1B3, ABCC2, SLCO1B1, UGT1A1
integral component of membrane (GO:0016021) 1.145UGT1A4, SLCO1B3, ABCC2, SLCO1B1, UGT1A1
membrane (GO:0016020) 0.685SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
cell part (GO:0044464) 0.115SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
intrinsic component of membrane (GO:0031224) 1.135SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
plasma membrane part (GO:0044459) 1.954SLCO1B1, ABCC2, SLCO1B3, UGT1A1
intrinsic component of plasma membrane (GO:0031226) 2.534SLCO1B1, ABCC2, SLCO1B3, UGT1A1
integral component of plasma membrane (GO:0005887) 2.574SLCO1B1, ABCC2, SLCO1B3, UGT1A1
plasma membrane region (GO:0098590) 2.973SLCO1B1, SLCO1B3, ABCC2
plasma membrane (GO:0005886) 1.393SLCO1B1, SLCO1B3, ABCC2
endoplasmic reticulum (GO:0005783) 2.562UGT1A4, UGT1A1
cytoplasmic part (GO:0044444) 0.822UGT1A4, UGT1A1
endoplasmic reticulum membrane (GO:0005789) 2.952UGT1A4, UGT1A1
intracellular organelle part (GO:0044446) 0.812UGT1A4, UGT1A1
endoplasmic reticulum part (GO:0044432) 2.732UGT1A4, UGT1A1
intracellular organelle (GO:0043229) 0.512UGT1A4, UGT1A1
intracellular part (GO:0044424) 0.282UGT1A4, UGT1A1
basolateral plasma membrane (GO:0016323) 4.562SLCO1B1, SLCO1B3
membrane-bounded organelle (GO:0043227) 0.472UGT1A4, UGT1A1
organelle (GO:0043226) 0.42UGT1A4, UGT1A1
organelle part (GO:0044422) 0.792UGT1A4, UGT1A1
intracellular membrane-bounded organelle (GO:0043231) 0.62UGT1A4, UGT1A1

NET-GE enrichment

Term New enriched termICP valueGenes
plasma membrane region (GO:0098590) -2.970.003SLCO1B1, SLCO1B3, ABCC2
membrane region (GO:0098589) NEW3.950.0SLCO1B1, SLCO1B3, ABCC2, UGT1A4, UGT1A1
plasma membrane part (GO:0044459) -1.950.029SLCO1B1, ABCC2, SLCO1B3, UGT1A1
integral component of plasma membrane (GO:0005887) -2.570.002SLCO1B1, ABCC2, SLCO1B3, UGT1A1
basolateral plasma membrane (GO:0016323) -4.560.021SLCO1B1, SLCO1B3