| Disease ID | Disease name | Source of annotation with IRF3 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS610551 | ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED | OMIM, HUMSAVAR | link to OMIM | 7 | TLR3, CPT2, IRF3, TICAM1, UNC93B1, TRAF3, RANBP2 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pertussis | hsa05133 | 6.46 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| RIG-I-like receptor signaling pathway | hsa04622 | 6.62 |
| Cytosolic DNA-sensing pathway | hsa04623 | 6.79 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Epstein-Barr virus infection | hsa05169 | 4.97 |
| Influenza A | hsa05164 | 5.21 |
| Hepatitis C | hsa05160 | 5.68 |
| Hepatitis B | hsa05161 | 5.52 |
| Measles | hsa05162 | 5.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 9.28 |
| Immune System | R-HSA-168256 | 2.37 |
| ISG15 antiviral mechanism | R-HSA-1169408 | 6.83 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 5.88 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 10.4 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 9.18 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| Interferon gamma signaling | R-HSA-877300 | 5.67 |
| MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 8.28 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 7.98 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Interferon Signaling | R-HSA-913531 | 4.95 |
| Negative regulators of RIG-I/MDA5 signaling | R-HSA-936440 | 7.98 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 6.94 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 8.98 |
| Antiviral mechanism by IFN-stimulated genes | R-HSA-1169410 | 6.83 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | R-HSA-3134973 | 10.66 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 9.08 |
| Interferon alpha/beta signaling | R-HSA-909733 | 6.04 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | R-HSA-936964 | 8.81 |
| GO term | GO ID | GO IC |
|---|---|---|
| RNA polymerase II regulatory region DNA binding | GO:0001012 | 3.36 |
| core promoter proximal region DNA binding | GO:0001159 | 3.82 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | GO:0001078 | 5.08 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| sequence-specific DNA binding | GO:0043565 | 2.79 |
| sequence-specific double-stranded DNA binding | GO:1990837 | 3.2 |
| transcription cofactor activity | GO:0003712 | 3.44 |
| identical protein binding | GO:0042802 | 2.63 |
| transcription factor activity, transcription factor binding | GO:0000989 | 3.36 |
| transcription factor activity, protein binding | GO:0000988 | 3.35 |
| core promoter proximal region sequence-specific DNA binding | GO:0000987 | 3.83 |
| double-stranded DNA binding | GO:0003690 | 3.09 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | GO:0000982 | 3.94 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | GO:0000981 | 3.29 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| regulatory region nucleic acid binding | GO:0001067 | 3.03 |
| protein dimerization activity | GO:0046983 | 2.72 |
| transcription regulatory region DNA binding | GO:0044212 | 3.03 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | GO:0001227 | 4.61 |
| transcription factor activity, sequence-specific DNA binding | GO:0003700 | 2.65 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| transcription regulatory region sequence-specific DNA binding | GO:0000976 | 3.24 |
| RNA polymerase II regulatory region sequence-specific DNA binding | GO:0000977 | 3.37 |
| protein binding | GO:0005515 | 0.46 |
| regulatory region DNA binding | GO:0000975 | 3.03 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | GO:0000978 | 3.88 |
| nucleic acid binding transcription factor activity | GO:0001071 | 2.65 |