Disease table of CEROID LIPOFUSCINOSES OMIM ID: PS256730

Gene-disease associations table

GeneAssociated with CEROID LIPOFUSCINOSES inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MFSD8ClinVar, OMIM, HUMSAVARHGNC link4q28.22PS256730, 616170
DNAJC5ClinVar, OMIM, HUMSAVARHGNC link20q13.331PS256730
CTSDClinVar, OMIM, HUMSAVARHGNC link11p15.51PS256730
CTSFClinVar, OMIM, HUMSAVARHGNC link11q13.21PS256730
TPP1ClinVar, OMIM, HUMSAVARHGNC link11p15.42PS256730, 609270
CLN6ClinVar, OMIM, HUMSAVARHGNC link15q231PS256730
CLN5ClinVar, OMIM, HUMSAVARHGNC link13q22.31PS256730
SMPD1ClinVarHGNC link11p15.43PS256730, 257200, 607616
PPT1ClinVar, OMIM, HUMSAVARHGNC link1p34.21PS256730
GRNOMIMHGNC link17q21.313PS256730, 607485, 600274
CLN3ClinVar, OMIM, HUMSAVARHGNC link16p12.11PS256730
CLN8ClinVar, OMIM, HUMSAVARHGNC link8p23.31PS256730

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
11p15.42SMPD1, TPP1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
11p153CTSD, SMPD1, TPP1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
11p13CTSD, SMPD1, TPP1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
11p3CTSD, SMPD1, TPP1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
114CTSD, CTSF, TPP1, SMPD1
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CTSDYES9ARNT, ESR2, TP53, USF2, USF1, ESR1, NFATC3, BRCA1, MYCN0
SMPD1YES1SP10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
DNAJC5CTSDNo1ATP6V1B1
DNAJC5GRNNo1CFTR
CTSDTPP1No1FBXO6
CTSDCLN6No2ILK, ENV
CTSDCLN5No1FBXO6
CTSDPPT1Yes3LDHA, LDHB, FBXO6
CTSDGRNNo2FBXO6, NAPSA
CTSDCLN3No1UQCRC2
CTSFCLN5No1PTPRK
TPP1CLN5No1FBXO6
TPP1PPT1No1FBXO6
TPP1GRNNo4FBXO6, POT1, EGFR, OBFC1
CLN6PPT1No1VCP
CLN5SMPD1No1OS9
CLN5PPT1No5DBH, CANX, FBXO6, SLC25A13, SLC25A1
CLN5GRNNo1FBXO6
CLN5CLN3No19SLC25A13, RCN2, SLC25A4, SLC25A5, ARF4, DBH, CALU, SFXN3, RPN1, XPO1, SEC61A1, SLC25A6, PHGDH, SLC25A11, GANAB, SLC25A22, CDS2, ATP2A2, SLC25A1
SMPD1CLN3No1ELAVL1
PPT1GRNNo1FBXO6
PPT1CLN3No6VDAC2, RIF1, DBH, SLC25A13, ATP1A1, SLC25A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
DNAJC5CTSDNo-1UBC
DNAJC5TPP1No-1UBC
DNAJC5PPT1No-1UBC
DNAJC5CLN3No-1UBC
CTSDCTSFNo-2HLA-DRB5, CD74
CTSDTPP1No-1UBC
CTSDPPT1No-1UBC
CTSDGRNNo-1LGALS3
CTSDCLN3No-1UBC
TPP1CLN5Yesbinding0
TPP1PPT1No-1UBC
TPP1CLN3No-1UBC
PPT1CLN3No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Lysosomehsa041425.788CLN3, CTSF, TPP1, SMPD1, PPT1, MFSD8, CTSD, CLN5
Metabolic pathwayshsa011002.492PPT1, SMPD1

NET-GE enrichment

Term New enriched termICP valueGenes
Transport and catabolismNEW3.490.0CTSF, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, CLN5
Lysosome (hsa04142) -5.780.0CTSF, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, CLN5
Cellular ProcessesNEW2.220.001CLN3, CTSF, TPP1, SMPD1, PPT1, MFSD8, CTSD, CLN5
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.372CTSF, CTSD
Adaptive Immune SystemR-HSA-12802183.192CTSF, CTSD
Metabolism of proteinsR-HSA-3924993.412TPP1, CTSD
MHC class II antigen presentationR-HSA-21322956.012CTSF, CTSD

NET-GE enrichment

Term New enriched termICP valueGenes
MHC class II antigen presentation (R-HSA-2132295) -6.010.049CTSF, CTSD
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.188GRN, CLN6, CTSD, TPP1, SMPD1, CLN3, DNAJC5, CLN5
protein binding (GO:0005515) 0.468GRN, CLN6, CTSD, TPP1, SMPD1, CLN3, DNAJC5, CLN5
hydrolase activity (GO:0016787) 1.95TPP1, PPT1, SMPD1, CTSF, CTSD
catalytic activity (GO:0003824) 1.055TPP1, PPT1, SMPD1, CTSF, CTSD
peptidase activity (GO:0008233) 3.233TPP1, CTSF, CTSD
endopeptidase activity (GO:0004175) 3.633TPP1, CTSF, CTSD
peptidase activity, acting on L-amino acid peptides (GO:0070011) 3.263TPP1, CTSF, CTSD
serine-type endopeptidase activity (GO:0004252) 4.42TPP1, CTSD
cation binding (GO:0043169) 1.42TPP1, SMPD1
serine hydrolase activity (GO:0017171) 4.262TPP1, CTSD
hydrolase activity, acting on ester bonds (GO:0016788) 3.12PPT1, SMPD1
ion binding (GO:0043167) 1.362TPP1, SMPD1
cysteine-type endopeptidase activity (GO:0004197) 5.282CTSF, CTSD
metal ion binding (GO:0046872) 1.412TPP1, SMPD1
cysteine-type peptidase activity (GO:0008234) 4.512CTSF, CTSD
serine-type peptidase activity (GO:0008236) 4.272TPP1, CTSD

NET-GE enrichment

Term New enriched termICP valueGenes
endopeptidase activity (GO:0004175) -3.630.028PPT1, TPP1, CTSD, GRN, CTSF
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2610CLN6, CLN8, PPT1, CTSD, TPP1, SMPD1, MFSD8, CLN3, CLN5, DNAJC5
single-organism process (GO:0044699) 0.4810GRN, CLN6, CLN8, TPP1, CTSD, PPT1, SMPD1, CLN3, CLN5, DNAJC5
organic substance metabolic process (GO:0071704) 0.639CTSF, CLN6, CLN8, PPT1, CTSD, TPP1, SMPD1, CLN3, CLN5
biological regulation (GO:0065007) 0.399GRN, CLN6, CLN8, TPP1, CLN3, PPT1, SMPD1, DNAJC5, CLN5
metabolic process (GO:0008152) 0.589CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, SMPD1, CLN3, CLN5
primary metabolic process (GO:0044238) 0.699CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, SMPD1, CLN3, CLN5
single-organism metabolic process (GO:0044710) 1.638CLN6, CLN8, TPP1, CTSD, PPT1, SMPD1, CLN3, CLN5
protein metabolic process (GO:0019538) 1.458CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, CLN3, CLN5
organic substance catabolic process (GO:1901575) 2.458CLN3, CLN6, CLN8, TPP1, SMPD1, PPT1, CTSD, CLN5
regulation of cellular process (GO:0050794) 0.58CLN6, GRN, CLN8, TPP1, CLN3, PPT1, SMPD1, DNAJC5
single-organism cellular process (GO:0044763) 0.658CLN6, CLN8, TPP1, CLN3, PPT1, SMPD1, CLN5, DNAJC5
macromolecule metabolic process (GO:0043170) 0.838CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, CLN3, CLN5
catabolic process (GO:0009056) 2.388CLN3, CLN6, CLN8, TPP1, SMPD1, PPT1, CTSD, CLN5
regulation of biological process (GO:0050789) 0.458CLN6, GRN, CLN8, TPP1, CLN3, PPT1, SMPD1, DNAJC5
organelle organization (GO:0006996) 2.027CLN6, CLN8, TPP1, CLN3, PPT1, MFSD8, CLN5
vacuole organization (GO:0007033) 4.677CLN6, CLN8, TPP1, CLN3, PPT1, MFSD8, CLN5
multicellular organismal process (GO:0032501) 1.457CLN6, CLN8, TPP1, CTSD, PPT1, CLN3, CLN5
organonitrogen compound metabolic process (GO:1901564) 2.327CLN6, CLN8, TPP1, CLN3, PPT1, SMPD1, CLN5
cellular metabolic process (GO:0044237) 0.697CLN6, CLN8, TPP1, CLN3, PPT1, SMPD1, CLN5
cellular component organization (GO:0016043) 1.247CLN6, CLN8, TPP1, CLN3, PPT1, MFSD8, CLN5
nitrogen compound metabolic process (GO:0006807) 1.137CLN6, CLN8, TPP1, SMPD1, PPT1, CLN3, CLN5
protein catabolic process (GO:0030163) 3.937CLN6, CLN8, TPP1, CTSD, PPT1, CLN3, CLN5
lysosome organization (GO:0007040) 6.027CLN6, CLN8, TPP1, CLN3, PPT1, MFSD8, CLN5
regulation of biological quality (GO:0065008) 1.687CLN6, CLN8, PPT1, CLN3, TPP1, DNAJC5, CLN5
macromolecule catabolic process (GO:0009057) 3.07CLN6, CLN8, TPP1, CTSD, PPT1, CLN3, CLN5
cellular component organization or biogenesis (GO:0071840) 1.227CLN6, CLN8, TPP1, CLN3, PPT1, MFSD8, CLN5
lytic vacuole organization (GO:0080171) 6.027CLN6, CLN8, TPP1, CLN3, PPT1, MFSD8, CLN5
lipid metabolic process (GO:0006629) 2.686CLN6, CLN8, TPP1, SMPD1, PPT1, CLN3
cellular amide metabolic process (GO:0043603) 3.236CLN6, CLN8, SMPD1, TPP1, CLN3, CLN5
neurological system process (GO:0050877) 2.646CLN6, CLN8, TPP1, CLN3, PPT1, CLN5
transport (GO:0006810) 1.516GRN, CLN8, CLN3, PPT1, MFSD8, DNAJC5
cellular nitrogen compound metabolic process (GO:0034641) 1.226CLN6, CLN8, SMPD1, TPP1, CLN3, CLN5
establishment of localization (GO:0051234) 1.486GRN, CLN8, CLN3, PPT1, MFSD8, DNAJC5
localization (GO:0051179) 1.46GRN, CLN8, CLN3, PPT1, MFSD8, DNAJC5
system process (GO:0003008) 2.36CLN6, CLN8, TPP1, CLN3, PPT1, CLN5
developmental process (GO:0032502) 1.365CLN8, PPT1, TPP1, CLN5, SMPD1
cellular catabolic process (GO:0044248) 2.625CLN8, PPT1, CLN6, TPP1, SMPD1
membrane lipid metabolic process (GO:0006643) 4.515CLN8, PPT1, SMPD1, CLN6, CLN3
establishment of localization in cell (GO:0051649) 2.475CLN8, PPT1, CLN3, DNAJC5, GRN
response to stimulus (GO:0050896) 1.225CLN8, PPT1, SMPD1, TPP1, GRN
anatomical structure development (GO:0048856) 1.585CLN8, PPT1, TPP1, CLN5, SMPD1
homeostatic process (GO:0042592) 2.615PPT1, CLN5, TPP1, CLN3, CLN6
regulation of programmed cell death (GO:0043067) 2.495CLN8, PPT1, SMPD1, DNAJC5, CLN3
proteolysis (GO:0006508) 2.735TPP1, CLN3, CLN5, CTSD, CTSF
negative regulation of biological process (GO:0048519) 1.335CLN8, PPT1, CLN3, DNAJC5, SMPD1
cellular lipid metabolic process (GO:0044255) 2.925CLN8, PPT1, SMPD1, CLN3, CLN6
regulation of cell death (GO:0010941) 2.435CLN8, PPT1, SMPD1, DNAJC5, CLN3
regulation of apoptotic process (GO:0042981) 2.55CLN8, PPT1, CLN3, DNAJC5, SMPD1
sphingolipid metabolic process (GO:0006665) 4.795PPT1, CLN8, CLN3, SMPD1, CLN6
negative regulation of cellular process (GO:0048523) 1.415CLN8, PPT1, SMPD1, DNAJC5, CLN3
regulation of lysosomal lumen pH (GO:0035751) 7.654PPT1, CLN5, CLN3, CLN6
regulation of primary metabolic process (GO:0080090) 1.084CLN8, SMPD1, CLN3, CLN6
regulation of metabolic process (GO:0019222) 1.024CLN8, SMPD1, CLN3, CLN6
ion homeostasis (GO:0050801) 3.424PPT1, CLN6, CLN5, CLN3
regulation of cellular metabolic process (GO:0031323) 1.074CLN8, SMPD1, CLN3, CLN6
behavior (GO:0007610) 3.474CLN8, PPT1, CLN3, GRN
inorganic ion homeostasis (GO:0098771) 3.434PPT1, CLN5, CLN3, CLN6
signal transduction (GO:0007165) 1.284TPP1, CLN3, SMPD1, GRN
regulation of intracellular pH (GO:0051453) 5.444PPT1, CLN5, CLN3, CLN6
intracellular pH reduction (GO:0051452) 6.094PPT1, CLN6, CLN5, CLN3
regulation of cellular pH (GO:0030641) 5.414PPT1, CLN6, CLN5, CLN3
cellular macromolecule metabolic process (GO:0044260) 0.934CLN8, PPT1, CLN5, CLN6
regulation of pH (GO:0006885) 5.244PPT1, CLN6, CLN5, CLN3
regulation of protein metabolic process (GO:0051246) 1.934CLN8, SMPD1, CLN3, CLN6
negative regulation of apoptotic process (GO:0043066) 3.044PPT1, DNAJC5, CLN8, CLN3
positive regulation of biological process (GO:0048518) 1.24PPT1, SMPD1, CLN6, GRN
regulation of neurotransmitter levels (GO:0001505) 4.774CLN8, PPT1, DNAJC5, CLN3
cellular homeostasis (GO:0019725) 3.234PPT1, CLN5, CLN3, CLN6
pH reduction (GO:0045851) 6.074PPT1, CLN6, CLN5, CLN3
regulation of macromolecule metabolic process (GO:0060255) 1.084CLN8, SMPD1, CLN3, CLN6
negative regulation of cell death (GO:0060548) 2.954CLN8, DNAJC5, PPT1, CLN3
visual perception (GO:0007601) 4.414CLN8, CLN5, PPT1, CLN6
sensory perception (GO:0007600) 2.934CLN8, PPT1, CLN5, CLN6
cellular ion homeostasis (GO:0006873) 3.574PPT1, CLN6, CLN5, CLN3
sensory perception of light stimulus (GO:0050953) 4.44CLN8, PPT1, CLN5, CLN6
cellular monovalent inorganic cation homeostasis (GO:0030004) 5.194PPT1, CLN5, CLN3, CLN6
single-organism transport (GO:0044765) 2.184PPT1, DNAJC5, CLN8, CLN3
monovalent inorganic cation homeostasis (GO:0055067) 4.934PPT1, CLN5, CLN3, CLN6
cellular cation homeostasis (GO:0030003) 3.64PPT1, CLN6, CLN5, CLN3
cation homeostasis (GO:0055080) 3.464PPT1, CLN5, CLN3, CLN6
cellular chemical homeostasis (GO:0055082) 3.44PPT1, CLN5, CLN3, CLN6
single-organism localization (GO:1902578) 2.094PPT1, DNAJC5, CLN8, CLN3
regulation of cellular protein metabolic process (GO:0032268) 1.994CLN8, CLN6, SMPD1, CLN3
vesicle-mediated transport (GO:0016192) 2.724PPT1, DNAJC5, CLN3, GRN
single-multicellular organism process (GO:0044707) 1.784CLN8, PPT1, CLN3, CTSD
vacuolar acidification (GO:0007035) 7.024PPT1, CLN5, CLN3, CLN6
negative regulation of programmed cell death (GO:0043069) 3.024CLN8, PPT1, DNAJC5, CLN3
nervous system development (GO:0007399) 3.534CLN8, PPT1, TPP1, SMPD1
chemical homeostasis (GO:0048878) 2.974PPT1, CLN6, CLN5, CLN3
cellular developmental process (GO:0048869) 1.824CLN8, PPT1, TPP1, CLN5
system development (GO:0048731) 2.924CLN8, TPP1, PPT1, SMPD1
positive regulation of cellular process (GO:0048522) 1.34PPT1, SMPD1, CLN6, GRN
ceramide metabolic process (GO:0006672) 5.414CLN8, CLN6, CLN3, SMPD1
lysosomal lumen acidification (GO:0007042) 8.124PPT1, CLN5, CLN3, CLN6
negative regulation of metabolic process (GO:0009892) 1.933CLN8, SMPD1, CLN3
cell differentiation (GO:0030154) 2.143CLN8, TPP1, CLN5
learning (GO:0007612) 4.853PPT1, CLN8, CLN3
learning or memory (GO:0007611) 4.333PPT1, CLN8, CLN3
cellular biosynthetic process (GO:0044249) 1.373PPT1, CLN8, SMPD1
regulation of neuron apoptotic process (GO:0043523) 4.473PPT1, DNAJC5, CLN3
negative regulation of neuron apoptotic process (GO:0043524) 4.823PPT1, DNAJC5, CLN3
small molecule metabolic process (GO:0044281) 2.383CLN8, CLN3, CLN6
neuromuscular process (GO:0050905) 5.273TPP1, CLN8, CLN3
single-organism catabolic process (GO:0044712) 3.213PPT1, SMPD1, CTSD
cellular protein metabolic process (GO:0044267) 1.633CLN8, PPT1, CLN5
negative regulation of protein metabolic process (GO:0051248) 2.823CLN8, SMPD1, CLN3
cellular macromolecule catabolic process (GO:0044265) 3.193PPT1, CLN8, CLN6
negative regulation of macromolecule metabolic process (GO:0010605) 2.013CLN8, CLN3, SMPD1
neuromuscular process controlling balance (GO:0050885) 5.883TPP1, CLN8, CLN3
glycosphingolipid metabolic process (GO:0006687) 5.493SMPD1, CLN3, CLN6
organic substance transport (GO:0071702) 2.153PPT1, CLN8, CLN3
regulation of molecular function (GO:0065009) 1.783PPT1, CLN3, SMPD1
glycolipid metabolic process (GO:0006664) 5.013CLN3, SMPD1, CLN6
liposaccharide metabolic process (GO:1903509) 4.983CLN3, SMPD1, CLN6
phospholipid metabolic process (GO:0006644) 3.883CLN8, SMPD1, CLN3
negative regulation of cellular metabolic process (GO:0031324) 2.013CLN8, CLN3, SMPD1
organic substance biosynthetic process (GO:1901576) 1.343PPT1, CLN8, SMPD1
regulation of catalytic activity (GO:0050790) 1.973PPT1, CLN3, SMPD1
biosynthetic process (GO:0009058) 1.323PPT1, CLN8, SMPD1
associative learning (GO:0008306) 5.443PPT1, CLN8, CLN3
regulation of proteolysis (GO:0030162) 3.23CLN8, CLN3, CLN6
neurotransmitter transport (GO:0006836) 5.073CLN8, PPT1, DNAJC5
regulation of neuron death (GO:1901214) 4.193DNAJC5, PPT1, CLN3
negative regulation of neuron death (GO:1901215) 4.573DNAJC5, PPT1, CLN3
negative regulation of cellular protein metabolic process (GO:0032269) 2.883CLN8, CLN3, SMPD1
endocytosis (GO:0006897) 3.693PPT1, CLN3, GRN
organonitrogen compound catabolic process (GO:1901565) 3.913TPP1, PPT1, SMPD1
membrane organization (GO:0061024) 3.043PPT1, CLN8, CLN3
single-organism behavior (GO:0044708) 3.793PPT1, CLN8, CLN3
carbohydrate derivative metabolic process (GO:1901135) 3.073CLN6, SMPD1, CLN3
receptor-mediated endocytosis (GO:0006898) 4.313PPT1, CLN3, GRN
cognition (GO:0050890) 4.23PPT1, CLN8, CLN3
phosphate-containing compound metabolic process (GO:0006796) 2.163CLN8, CLN3, SMPD1
phosphorus metabolic process (GO:0006793) 2.153CLN8, SMPD1, CLN3
organophosphate metabolic process (GO:0019637) 3.043CLN8, SMPD1, CLN3
signal release from synapse (GO:0099643) 5.162DNAJC5, PPT1
steroid metabolic process (GO:0008202) 4.322CLN8, CLN6
positive regulation of metabolic process (GO:0009893) 1.742SMPD1, CLN6
sphingolipid catabolic process (GO:0030149) 6.642PPT1, SMPD1
vesicle localization (GO:0051648) 4.852DNAJC5, CLN3
positive regulation of cellular metabolic process (GO:0031325) 1.812SMPD1, CLN6
(GO:0099003) 5.512DNAJC5, GRN
negative regulation of proteolysis (GO:0045861) 3.982CLN8, CLN3
antigen processing and presentation of peptide antigen via MHC class II (GO:0002495) 5.192CTSF, CTSD
regulation of cellular component organization (GO:0051128) 2.012PPT1, GRN
protein processing (GO:0016485) 4.622CLN5, CLN3
anion transport (GO:0006820) 3.712CLN8, CLN3
antigen processing and presentation of peptide antigen (GO:0048002) 4.562CTSF, CTSD
cellular lipid catabolic process (GO:0044242) 4.732PPT1, SMPD1
establishment of organelle localization (GO:0051656) 4.152DNAJC5, CLN3
establishment of vesicle localization (GO:0051650) 4.912DNAJC5, CLN3
response to organic cyclic compound (GO:0014070) 3.072SMPD1, GRN
immune system process (GO:0002376) 2.292CTSF, CTSD
cholesterol metabolic process (GO:0008203) 5.032CLN8, CLN6
single-organism biosynthetic process (GO:0044711) 2.82CLN8, SMPD1
negative regulation of catalytic activity (GO:0043086) 3.02CLN3, SMPD1
positive regulation of macromolecule metabolic process (GO:0010604) 1.812SMPD1, CLN6
ammonium ion metabolic process (GO:0097164) 5.262SMPD1, CLN3
positive regulation of protein metabolic process (GO:0051247) 2.432SMPD1, CLN6
amide biosynthetic process (GO:0043604) 3.62CLN8, SMPD1
adult locomotory behavior (GO:0008344) 5.32PPT1, CLN8
nitrogen compound transport (GO:0071705) 3.542CLN8, CLN3
animal organ development (GO:0048513) 2.532PPT1, CLN5
positive regulation of cellular protein metabolic process (GO:0032270) 2.492SMPD1, CLN6
organic cyclic compound metabolic process (GO:1901360) 1.262CLN8, CLN6
sphingomyelin metabolic process (GO:0006684) 7.162SMPD1, CLN3
negative regulation of molecular function (GO:0044092) 2.742SMPD1, CLN3
membrane lipid catabolic process (GO:0046466) 6.512PPT1, SMPD1
antigen processing and presentation of exogenous peptide antigen (GO:0002478) 4.632CTSF, CTSD
lipid biosynthetic process (GO:0008610) 3.492CLN8, SMPD1
carboxylic acid transport (GO:0046942) 4.282CLN8, CLN3
autophagy (GO:0006914) 3.822CLN3, CTSD
sphingolipid biosynthetic process (GO:0030148) 5.382CLN8, SMPD1
locomotory behavior (GO:0007626) 4.532PPT1, CLN8
antigen processing and presentation (GO:0019882) 4.362CTSF, CTSD
sterol metabolic process (GO:0016125) 4.922CLN8, CLN6
antigen processing and presentation of exogenous antigen (GO:0019884) 4.592CTSF, CTSD
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886) 5.212CTSF, CTSD
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504) 5.142CTSF, CTSD
amino acid transport (GO:0006865) 5.292CLN8, CLN3
ion transport (GO:0006811) 2.662CLN8, CLN3
organic anion transport (GO:0015711) 4.072CLN8, CLN3
signal release (GO:0023061) 4.652PPT1, DNAJC5
single-organism developmental process (GO:0044767) 1.492PPT1, CLN5
secondary alcohol metabolic process (GO:1902652) 5.02CLN8, CLN6
response to stress (GO:0006950) 1.82TPP1, CLN8
single-organism membrane organization (GO:0044802) 3.192PPT1, CLN8
neurotransmitter secretion (GO:0007269) 5.72PPT1, DNAJC5
membrane lipid biosynthetic process (GO:0046467) 4.992CLN8, SMPD1
cellular protein catabolic process (GO:0044257) 6.512PPT1, CLN8
response to chemical (GO:0042221) 1.982SMPD1, GRN
response to organic substance (GO:0010033) 2.22SMPD1, GRN
organelle localization (GO:0051640) 3.942DNAJC5, CLN3
cellular localization (GO:0051641) 2.322DNAJC5, CLN3
response to oxygen-containing compound (GO:1901700) 2.572SMPD1, GRN
adult behavior (GO:0030534) 4.792PPT1, CLN8
secretion (GO:0046903) 3.382PPT1, DNAJC5
single-organism cellular localization (GO:1902580) 3.162DNAJC5, CLN3
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592CLN8, SMPD1
brain development (GO:0007420) 4.242PPT1, CLN5
organonitrogen compound biosynthetic process (GO:1901566) 2.852CLN8, SMPD1
secretion by cell (GO:0032940) 3.592DNAJC5, PPT1
lipid catabolic process (GO:0016042) 4.212PPT1, SMPD1
alcohol metabolic process (GO:0006066) 4.22CLN8, CLN6
single-organism organelle organization (GO:1902589) 2.682CLN8, CLN3
presynaptic process involved in chemical synaptic transmission (GO:0099531) 4.982DNAJC5, PPT1
peptide metabolic process (GO:0006518) 3.442TPP1, CLN5
protein maturation (GO:0051604) 4.482CLN5, CLN3
positive regulation of cellular component organization (GO:0051130) 2.682PPT1, GRN
ceramide biosynthetic process (GO:0046513) 5.942CLN8, SMPD1
organic hydroxy compound metabolic process (GO:1901615) 3.842CLN8, CLN6

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of lysosomal lumen pH (GO:0035751) -7.650.0PPT1, CLN5, CLN3, CLN6
lysosome organization (GO:0007040) -6.020.0CLN8, TPP1, PPT1, CLN3
learning (GO:0007612) -4.850.025PPT1, CLN8, CLN3
negative regulation of neuron apoptotic process (GO:0043524) -4.820.038PPT1, DNAJC5, CLN3
regulation of neurotransmitter levels (GO:0001505) -4.770.01PPT1, DNAJC5, CLN8, CLN3
neuromuscular process (GO:0050905) -5.270.008TPP1, CLN8, CLN3
regulation of intracellular pH (GO:0051453) -5.440.0PPT1, CLN6, CLN5, CLN3
intracellular pH reduction (GO:0051452) -6.090.0PPT1, CLN5, CLN3, CLN6
cell death (GO:0008219) NEW3.050.0CLN3, CTSF, CLN6, CLN8, PPT1, CTSD, TPP1, MFSD8, SMPD1, GRN, CLN5, DNAJC5
regulation of cellular pH (GO:0030641) -5.410.0PPT1, CLN5, CLN3, CLN6
lipid metabolic process (GO:0006629) -2.680.017CLN6, CLN8, TPP1, SMPD1, PPT1, CLN3
organic substance catabolic process (GO:1901575) -2.450.039CLN6, CLN8, TPP1, SMPD1, PPT1, CLN3, CLN5
neuromuscular process controlling balance (GO:0050885) -5.880.036TPP1, CLN8, CLN3
regulation of pH (GO:0006885) -5.240.0PPT1, CLN6, CLN5, CLN3
cellular ion homeostasis (GO:0006873) -3.570.049PPT1, CLN6, CLN5, CLN3
glycosphingolipid metabolic process (GO:0006687) -5.490.026SMPD1, CLN3, CLN6
sphingomyelin metabolic process (GO:0006684) -7.160.04SMPD1, CLN3
glycolipid metabolic process (GO:0006664) -5.010.015CLN3, SMPD1, CLN6
sphingolipid metabolic process (GO:0006665) -4.790.0PPT1, CLN8, CLN3, SMPD1, CLN6
sphingolipid catabolic process (GO:0030149) -6.640.043PPT1, SMPD1
pH reduction (GO:0045851) -6.070.0PPT1, CLN6, CLN5, CLN3
membrane lipid metabolic process (GO:0006643) -4.510.0PPT1, CLN8, SMPD1, CLN3, CLN6
neurological system process (GO:0050877) -2.640.001CLN6, CLN8, TPP1, CLN3, PPT1, CLN5
visual perception (GO:0007601) -4.410.003CLN8, CLN5, PPT1, CLN6
sensory perception of light stimulus (GO:0050953) -4.40.003CLN8, CLN5, PPT1, CLN6
cellular monovalent inorganic cation homeostasis (GO:0030004) -5.190.0PPT1, CLN6, CLN5, CLN3
associative learning (GO:0008306) -5.440.004PPT1, CLN8, CLN3
lysosomal lumen acidification (GO:0007042) -8.120.0PPT1, CLN5, CLN3, CLN6
protein catabolic process (GO:0030163) -3.930.0CLN6, CLN8, TPP1, CTSD, PPT1, CLN3, CLN5
cellular cation homeostasis (GO:0030003) -3.60.043PPT1, CLN6, CLN5, CLN3
neurotransmitter transport (GO:0006836) -5.070.019CLN8, PPT1, DNAJC5
cellular protein catabolic process (GO:0044257) -6.510.032PPT1, CLN8
catabolic process (GO:0009056) -2.380.006CLN3, CLN6, CLN8, TPP1, SMPD1, PPT1, CTSD, CLN5
macromolecule catabolic process (GO:0009057) -3.00.003CLN6, CLN8, TPP1, CLN3, PPT1, CLN5
system process (GO:0003008) -2.30.017CLN6, CLN8, TPP1, CLN3, PPT1, CLN5
vacuole organization (GO:0007033) -4.670.0CLN8, PPT1, TPP1, CTSD, CLN3
organonitrogen compound metabolic process (GO:1901564) -2.320.026CLN6, CLN8, TPP1, SMPD1, PPT1, CLN3, CLN5
nervous system development (GO:0007399) -3.530.011CLN8, PPT1, TPP1, SMPD1
cellular amide metabolic process (GO:0043603) -3.230.039TPP1, SMPD1, CLN5, CLN3
alcohol metabolic process (GO:0006066) -4.20.025CLN8, SMPD1, CLN3, CLN6
ceramide metabolic process (GO:0006672) -5.410.0CLN8, SMPD1, CLN3, CLN6
monovalent inorganic cation homeostasis (GO:0055067) -4.930.0PPT1, CLN6, CLN5, CLN3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.612CLN6, CTSF, CLN8, PPT1, CTSD, TPP1, SMPD1, MFSD8, CLN3, GRN, DNAJC5, CLN5
cell part (GO:0044464) 0.1112CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, GRN, CLN5, DNAJC5
intracellular organelle (GO:0043229) 0.5112CLN3, CLN6, CTSF, CLN8, PPT1, CTSD, TPP1, MFSD8, SMPD1, GRN, DNAJC5, CLN5
cytoplasmic part (GO:0044444) 0.8212CLN6, CTSF, CLN8, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, GRN, CLN5, DNAJC5
intracellular part (GO:0044424) 0.2812CLN6, CTSF, CLN8, PPT1, CTSD, TPP1, SMPD1, MFSD8, CLN3, GRN, DNAJC5, CLN5
membrane-bounded organelle (GO:0043227) 0.4712CLN6, CTSF, CLN8, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, GRN, CLN5, DNAJC5
organelle (GO:0043226) 0.412CLN6, CTSF, CLN8, PPT1, CTSD, TPP1, SMPD1, MFSD8, CLN3, GRN, DNAJC5, CLN5
intracellular organelle part (GO:0044446) 0.8111CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, CLN5, DNAJC5
organelle part (GO:0044422) 0.7911CLN3, CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, MFSD8, SMPD1, DNAJC5, CLN5
membrane (GO:0016020) 0.689CLN6, CLN8, CTSD, PPT1, SMPD1, MFSD8, CLN3, CLN5, DNAJC5
vacuolar part (GO:0044437) 3.269CTSF, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, CLN5, DNAJC5
vesicle (GO:0031982) 1.649GRN, CTSF, TPP1, CTSD, PPT1, SMPD1, CLN3, CLN5, DNAJC5
membrane-bounded vesicle (GO:0031988) 1.719GRN, CTSF, TPP1, CTSD, PPT1, SMPD1, CLN3, CLN5, DNAJC5
extracellular organelle (GO:0043230) 1.898GRN, CTSF, TPP1, SMPD1, PPT1, CTSD, CLN5, DNAJC5
extracellular exosome (GO:0070062) 1.898GRN, CTSF, TPP1, SMPD1, PPT1, CTSD, DNAJC5, CLN5
lytic vacuole (GO:0000323) 3.898CLN3, CTSF, PPT1, SMPD1, TPP1, MFSD8, CTSD, CLN5
vacuole (GO:0005773) 2.928CLN3, CTSF, PPT1, SMPD1, TPP1, MFSD8, CTSD, CLN5
lysosome (GO:0005764) 3.898CTSF, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, CLN5
membrane part (GO:0044425) 0.958CLN6, CLN8, CTSD, PPT1, SMPD1, MFSD8, CLN3, CLN5
extracellular vesicle (GO:1903561) 1.898GRN, CTSF, PPT1, SMPD1, TPP1, CTSD, CLN5, DNAJC5
extracellular region part (GO:0044421) 1.578GRN, CTSF, TPP1, SMPD1, PPT1, CTSD, CLN5, DNAJC5
intracellular organelle lumen (GO:0070013) 3.057CTSF, CLN6, PPT1, CTSD, TPP1, SMPD1, CLN5
membrane-enclosed lumen (GO:0031974) 3.057CTSF, CLN6, PPT1, CTSD, TPP1, SMPD1, CLN5
organelle lumen (GO:0043233) 3.057CTSF, CLN6, PPT1, CTSD, TPP1, SMPD1, CLN5
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.126TPP1, CLN3, PPT1, SMPD1, CTSD, DNAJC5
cytoplasmic vesicle (GO:0031410) 2.876TPP1, SMPD1, PPT1, CLN3, CTSD, DNAJC5
integral component of membrane (GO:0016021) 1.146CLN6, CLN8, SMPD1, MFSD8, CLN3, CLN5
vacuolar lumen (GO:0005775) 5.066CTSF, PPT1, SMPD1, TPP1, CTSD, CLN5
intracellular vesicle (GO:0097708) 2.866TPP1, SMPD1, PPT1, CLN3, CTSD, DNAJC5
intrinsic component of membrane (GO:0031224) 1.136CLN6, CLN8, SMPD1, MFSD8, CLN3, CLN5
bounding membrane of organelle (GO:0098588) 2.395CLN8, DNAJC5, MFSD8, CLN5, CLN3
lysosomal lumen (GO:0043202) 5.325PPT1, TPP1, SMPD1, CTSD, CTSF
organelle membrane (GO:0031090) 1.975CLN8, DNAJC5, MFSD8, CLN5, CLN3
extracellular space (GO:0005615) 2.635CTSD, PPT1, SMPD1, GRN, CTSF
endoplasmic reticulum (GO:0005783) 2.564CLN8, CLN5, CLN3, CLN6
secretory vesicle (GO:0099503) 4.04PPT1, DNAJC5, SMPD1, CLN3
lysosomal membrane (GO:0005765) 4.194CLN5, MFSD8, DNAJC5, CLN3
whole membrane (GO:0098805) 2.854DNAJC5, MFSD8, CLN5, CLN3
mitochondrion (GO:0005739) 2.424CLN8, DNAJC5, TPP1, CLN3
vacuolar membrane (GO:0005774) 3.454CLN5, MFSD8, DNAJC5, CLN3
neuron part (GO:0097458) 2.644PPT1, DNAJC5, CLN8, CLN3
synapse part (GO:0044456) 3.424PPT1, DNAJC5, CLN8, CLN3
lytic vacuole membrane (GO:0098852) 4.194CLN5, MFSD8, DNAJC5, CLN3
extracellular region (GO:0005576) 2.184PPT1, SMPD1, CTSD, GRN
Golgi apparatus (GO:0005794) 2.73PPT1, CLN5, CLN3
melanosome (GO:0042470) 5.223TPP1, DNAJC5, CTSD
synaptic vesicle (GO:0008021) 5.193PPT1, DNAJC5, CLN3
cytosol (GO:0005829) 1.683DNAJC5, PPT1, GRN
membrane region (GO:0098589) 3.953PPT1, CLN3, CTSD
pigment granule (GO:0048770) 5.223TPP1, DNAJC5, CTSD
exocytic vesicle (GO:0070382) 5.033DNAJC5, PPT1, CLN3
endoplasmic reticulum part (GO:0044432) 2.733CLN8, CLN3, CLN6
plasma membrane (GO:0005886) 1.393DNAJC5, CLN3, SMPD1
transport vesicle (GO:0030133) 4.33DNAJC5, PPT1, CLN3
membrane microdomain (GO:0098857) 4.173PPT1, CLN3, CTSD
membrane raft (GO:0045121) 4.183PPT1, CLN3, CTSD
nucleus (GO:0005634) 1.072PPT1, CLN3
endoplasmic reticulum membrane (GO:0005789) 2.952CLN8, CLN6
presynapse (GO:0098793) 4.972DNAJC5, CLN8
neuron projection (GO:0043005) 3.122PPT1, CLN3
cell projection (GO:0042995) 2.472PPT1, CLN3
endosome (GO:0005768) 3.252CLN3, SMPD1

NET-GE enrichment

Term New enriched termICP valueGenes
synaptic vesicle (GO:0008021) -5.190.002PPT1, DNAJC5, CLN3
lytic vacuole (GO:0000323) -3.890.0CTSF, TPP1, CTSD, PPT1, MFSD8, CLN3, CLN5
pigment granule (GO:0048770) -5.220.002TPP1, DNAJC5, CTSD
membrane-enclosed lumen (GO:0031974) -3.050.0CTSF, CLN6, CTSD, TPP1, SMPD1, CLN5
intracellular organelle (GO:0043229) -0.510.021CLN3, CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, MFSD8, SMPD1, GRN, CLN5, DNAJC5
mitochondrion (GO:0005739) -2.420.004GRN, CLN8, CLN3, TPP1, CTSD, DNAJC5
membrane-bounded vesicle (GO:0031988) -1.710.001GRN, CTSF, TPP1, CTSD, PPT1, SMPD1, CLN3, DNAJC5, CLN5
membrane-bounded organelle (GO:0043227) -0.470.037CLN3, CTSF, CLN6, CLN8, PPT1, CTSD, TPP1, MFSD8, SMPD1, GRN, CLN5, DNAJC5
lysosomal lumen (GO:0043202) -5.320.0TPP1, SMPD1, CTSD, CTSF
vesicle (GO:0031982) -1.640.001GRN, CTSF, TPP1, CTSD, PPT1, SMPD1, CLN3, DNAJC5, CLN5
intracellular organelle lumen (GO:0070013) -3.050.042CTSF, CLN6, CTSD, TPP1, SMPD1, CLN5
vacuole (GO:0005773) -2.920.0CTSF, TPP1, CTSD, PPT1, MFSD8, CLN3, CLN5
cytoplasmic vesicle (GO:0031410) -2.870.0TPP1, CLN3, PPT1, SMPD1, CTSD, DNAJC5
vacuolar lumen (GO:0005775) -5.060.0CLN5, TPP1, CTSD, SMPD1, CTSF
vacuolar membrane (GO:0005774) -3.450.002CLN5, DNAJC5, MFSD8, CTSD, CLN3
vacuolar part (GO:0044437) -3.260.0CLN3, CTSF, SMPD1, TPP1, MFSD8, CTSD, CLN5, DNAJC5
cytoplasmic membrane-bounded vesicle (GO:0016023) -3.120.0TPP1, CLN3, PPT1, SMPD1, CTSD, DNAJC5
extracellular vesicular exosome (GO:0070062) -1.890.004GRN, CTSF, TPP1, SMPD1, PPT1, CTSD, CLN5, DNAJC5
melanosome (GO:0042470) -5.220.019DNAJC5, TPP1, CTSD
extracellular organelle (GO:0043230) -1.890.004GRN, CTSF, PPT1, SMPD1, TPP1, CTSD, CLN5, DNAJC5
intracellular membrane-bounded organelle (GO:0043231) -0.60.005CTSF, CLN6, CLN8, TPP1, CTSD, PPT1, SMPD1, MFSD8, CLN3, GRN, CLN5, DNAJC5
organelle lumen (GO:0043233) -3.050.0CTSF, CLN6, CTSD, TPP1, SMPD1, CLN5
lysosome (GO:0005764) -3.890.0CTSF, TPP1, CTSD, PPT1, MFSD8, CLN3, CLN5
lysosomal membrane (GO:0005765) -4.190.001CLN5, DNAJC5, MFSD8, CLN3, CTSD
cytoplasmic part (GO:0044444) -0.820.001CTSF, CLN6, CLN8, PPT1, CTSD, TPP1, SMPD1, MFSD8, CLN3, GRN, CLN5, DNAJC5
extracellular membrane-bounded organelle (GO:0065010) NEW8.70.004GRN, CTSF, TPP1, SMPD1, PPT1, CTSD, CLN5, DNAJC5
extracellular region part (GO:0044421) -1.570.035GRN, CTSF, PPT1, SMPD1, TPP1, CTSD, CLN5, DNAJC5