Gene table of EGFR : epidermal growth factor receptor

Gene-disease associations table

Disease ID	Disease name	Source of annotation with EGFR	OMIM link	Number of associated genes	genes
275355	SQUAMOUS CELL CARCINOMA, HEAD AND NECK	ClinVar	link to OMIM	5	TNFRSF10B, ING1, PTEN, EGFR, ING3
211980	LUNG CANCER	OMIM	link to OMIM	17	RASSF1, PARK2, IRF1, CASP8, ERBB2, PPP2R1B, FASLG, MAP3K8, PIK3CA, BRAF, KRAS, DLEC1, SLC22A18, ERCC6, CYP2A6, MXRA5, EGFR
PS614328	NEONATAL INFLAMMATORY SKIN AND BOWEL DISEASE	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	EGFR, ADAM17

Download the gene annotation in CSV format

Annotation of the gene EGFR

Associated genes in ENSEMBL

ENSG00000146648

Associated proteins - SwissProt Accession ID

P00533

Associated PDB IDs

Cytogenetic Band

7p11.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Bladder cancer	hsa05219	7.38
FoxO signaling pathway	hsa04068	5.63
Pancreatic cancer	hsa05212	6.56
Endometrial cancer	hsa05213	6.81
Calcium signaling pathway	hsa04020	5.22
MAPK signaling pathway	hsa04010	4.63
Glioma	hsa05214	6.66
Prostate cancer	hsa05215	6.11
Central carbon metabolism in cancer	hsa05230	6.7
Choline metabolism in cancer	hsa05231	6.09
Focal adhesion	hsa04510	4.92
HIF-1 signaling pathway	hsa04066	5.9
Cytokine-cytokine receptor interaction	hsa04060	4.67
Oxytocin signaling pathway	hsa04921	5.4
PI3K-Akt signaling pathway	hsa04151	4.21
Hepatitis C	hsa05160	5.68
Epithelial cell signaling in Helicobacter pylori infection	hsa05120	6.58
Gap junction	hsa04540	6.24
Proteoglycans in cancer	hsa05205	5.02
MicroRNAs in cancer	hsa05206	5.38
Pathways in cancer	hsa05200	3.98
GnRH signaling pathway	hsa04912	6.18
Rap1 signaling pathway	hsa04015	4.97
Adherens junction	hsa04520	6.26
Non-small cell lung cancer	hsa05223	6.88
ErbB signaling pathway	hsa04012	6.15
Estrogen signaling pathway	hsa04915	6.11
Regulation of actin cytoskeleton	hsa04810	4.9
Ras signaling pathway	hsa04014	4.9
Dorso-ventral axis formation	hsa04320	8.01
Endocytosis	hsa04144	4.92

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
PLCG1 events in ERBB2 signaling	R-HSA-1251932	7.85
Interleukin-2 signaling	R-HSA-451927	5.05
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
GAB1 signalosome	R-HSA-180292	6.31
Developmental Biology	R-HSA-1266738	3.48
Signaling by VEGF	R-HSA-194138	4.66
FCERI mediated MAPK activation	R-HSA-2871796	4.32
IRS-mediated signalling	R-HSA-112399	4.87
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
L1CAM interactions	R-HSA-373760	6.19
Signaling by Overexpressed Wild-Type EGFR in Cancer	R-HSA-5638302	11.98
Inhibition of Signaling by Overexpressed EGFR	R-HSA-5638303	11.98
Signaling by EGFR	R-HSA-177929	4.59
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
DAP12 interactions	R-HSA-2172127	4.56
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by ERBB2	R-HSA-1227986	4.66
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07
PI3K/AKT activation	R-HSA-198203	6.32
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15
Frs2-mediated activation	R-HSA-170968	5.12
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Downstream signal transduction	R-HSA-186763	4.65
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Signaling by EGFR in Cancer	R-HSA-1643713	8.73
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Interleukin receptor SHC signaling	R-HSA-912526	5.09
Innate Immune System	R-HSA-168249	3.17
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
Prolonged ERK activation events	R-HSA-169893	5.11
Signaling by FGFR2	R-HSA-5654738	4.68
GRB2 events in EGFR signaling	R-HSA-179812	5.15
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
EGFR Transactivation by Gastrin	R-HSA-2179392	9.81
Axon guidance	R-HSA-422475	3.93
Signaling by Leptin	R-HSA-2586552	5.1
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05
IGF1R signaling cascade	R-HSA-2428924	4.85
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
Signaling by Insulin receptor	R-HSA-74752	4.73
Disease	R-HSA-1643685	3.33
Insulin receptor signalling cascade	R-HSA-74751	4.85
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
Immune System	R-HSA-168256	2.37
Signalling to RAS	R-HSA-167044	5.08
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
SHC1 events in EGFR signaling	R-HSA-180336	5.15
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14
Signaling by GPCR	R-HSA-372790	2.68
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15
ARMS-mediated activation	R-HSA-170984	5.12
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15
Signaling by PDGF	R-HSA-186797	4.53
Signal transduction by L1	R-HSA-445144	8.59
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85
Signaling by Interleukins	R-HSA-449147	4.71
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
SOS-mediated signalling	R-HSA-112412	5.15
Signaling by ERBB4	R-HSA-1236394	4.7
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11
Adaptive Immune System	R-HSA-1280218	3.19
MAPK family signaling cascades	R-HSA-5683057	4.89
PIP3 activates AKT signaling	R-HSA-1257604	6.37
RAF/MAP kinase cascade	R-HSA-5673001	5.15
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
Signaling by FGFR	R-HSA-190236	4.67
Signaling by SCF-KIT	R-HSA-1433557	4.73
NCAM signaling for neurite out-growth	R-HSA-375165	4.9
DAP12 signaling	R-HSA-2424491	4.64
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.89
Signalling by NGF	R-HSA-166520	4.23
EGFR downregulation	R-HSA-182971	8.28
Signalling to ERKs	R-HSA-187687	5.04
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
Ras guanyl-nucleotide exchange factor activity	GO:0005088	4.31
ubiquitin-like protein ligase binding	GO:0044389	4.15
nucleic acid binding	GO:0003676	1.44
purine ribonucleoside triphosphate binding	GO:0035639	2.22
guanyl-nucleotide exchange factor activity	GO:0005085	4.02
enzyme binding	GO:0019899	2.27
ribonucleoside binding	GO:0032549	2.22
molecular transducer activity	GO:0060089	2.32
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
transmembrane receptor protein kinase activity	GO:0019199	5.32
signaling receptor activity	GO:0038023	2.49
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	5.61
actin binding	GO:0003779	3.74
molecular function regulator	GO:0098772	2.51
phosphatidylinositol bisphosphate kinase activity	GO:0052813	5.56
receptor signaling protein activity	GO:0005057	4.76
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
nucleotide binding	GO:0000166	1.96
receptor signaling protein tyrosine kinase activity	GO:0004716	7.44
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
identical protein binding	GO:0042802	2.63
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
double-stranded DNA binding	GO:0003690	3.09
ubiquitin protein ligase binding	GO:0031625	4.17
ATP binding	GO:0005524	2.43
protein tyrosine kinase activity	GO:0004713	4.54
kinase activity	GO:0016301	2.93
nitric-oxide synthase regulator activity	GO:0030235	7.79
enzyme regulator activity	GO:0030234	2.85
receptor signaling protein serine/threonine kinase activity	GO:0004702	5.23
actin filament binding	GO:0051015	4.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
protein heterodimerization activity	GO:0046982	3.64
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
cytoskeletal protein binding	GO:0008092	3.02
phosphatidylinositol 3-kinase activity	GO:0035004	5.49
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
protein binding	GO:0005515	0.46
epidermal growth factor-activated receptor activity	GO:0005006	9.05
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
chromatin binding	GO:0003682	3.64
MAP kinase kinase kinase activity	GO:0004709	6.6
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32