Disease table of AGAMMAGLOBULINEMIA OMIM ID: PS601495

Gene-disease associations table

GeneAssociated with AGAMMAGLOBULINEMIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
LRRC8AOMIMHGNC link9q34.111PS601495
PIK3R1ClinVar, OMIMHGNC link5q13.13616005, PS601495, 269880
IGLL1ClinVar, OMIM, HUMSAVARHGNC link22q11.231PS601495
BLNKClinVar, OMIMHGNC link10q24.11PS601495
CD79BClinVar, OMIM, HUMSAVARHGNC link17q23.31PS601495
IGHMClinVar, OMIMHGNC link14q32.331PS601495
BTKClinVar, OMIM, HUMSAVARHGNC linkXq22.12307200, PS601495
CD79AClinVar, OMIMHGNC link19q13.21PS601495

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
BTKYES3SP1, SP3, SPI10
CD79AYES2CHD4, PAX50
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
LRRC8APIK3R1No1NTRK1
LRRC8ACD79BNo1ELAVL1
PIK3R1BLNKNo10PTPN6, CBL, VAV1, SH3KBP1, ERBB2, NCK1, PLCG2, SYK, GRB2, CRKL
PIK3R1CD79BNo1SYK
PIK3R1BTKNo13ARHGAP17, CBL, VAV1, MED28, KHDRBS1, WAS, GRB2, GNAQ, PLCG2, SYK, CBLB, FYN, FASLG
PIK3R1CD79ANo1SYK
BLNKCD79BNo2SYK, CD79A
BLNKBTKYes7BTK, CBL, VAV1, LYN, PLCG2, GRB2, SYK
BLNKCD79AYes1SYK
CD79BBTKNo1SYK
CD79BCD79AYes4SYK, CD19, BLK, PTPRC
IGHMBTKNo2EWSR1, APP
BTKCD79ANo2SYK, BLNK

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
PIK3R1BLNKNo-1SH3KBP1
IGLL1IGHMYesIGHM-VPREB1-IGLL1 complex1VPREB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
B cell receptor signaling pathwayhsa046626.525BTK, BLNK, CD79A, PIK3R1, CD79B
Primary immunodeficiencyhsa053407.524IGLL1, CD79A, BLNK, BTK
Osteoclast differentiationhsa043805.643PIK3R1, BLNK, BTK
Fc epsilon RI signaling pathwayhsa046646.62PIK3R1, BTK
NF-kappa B signaling pathwayhsa040646.212BLNK, BTK
Platelet activationhsa046115.662PIK3R1, BTK

NET-GE enrichment

Term New enriched termICP valueGenes
Immune diseasesNEW4.470.005IGLL1, BTK, BLNK, PIK3R1, CD79A, IGHM
B cell receptor signaling pathway (hsa04662) -6.520.0PIK3R1, CD79A, BTK, CD79B, BLNK
Immune systemNEW2.920.02PIK3R1, CD79A, BTK, CD79B, BLNK
Osteoclast differentiation (hsa04380) -5.640.014PIK3R1, BLNK, BTK
Primary immunodeficiency (hsa05340) -7.520.0BTK, IGLL1, CD79A, BLNK, IGHM
NF-kappa B signaling pathway (hsa04064) -6.210.033PIK3R1, BLNK, BTK
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-9836955.66CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
Immune SystemR-HSA-1682562.376CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
Adaptive Immune SystemR-HSA-12802183.196CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.626CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
Signal TransductionR-HSA-1625821.782PIK3R1, BTK
Regulation of signaling by CBLR-HSA-9126318.522PIK3R1, BLNK
Signaling by InterleukinsR-HSA-4491474.712PIK3R1, BLNK
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032PIK3R1, BTK
Innate Immune SystemR-HSA-1682493.172PIK3R1, BTK
Cytokine Signaling in Immune systemR-HSA-12802153.742PIK3R1, BLNK
DAP12 interactionsR-HSA-21721274.562PIK3R1, BTK
DAP12 signalingR-HSA-24244914.642PIK3R1, BTK
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.992PIK3R1, BLNK
Fcgamma receptor (FCGR) dependent phagocytosisR-HSA-20294805.072PIK3R1, BTK
DiseaseR-HSA-16436853.332PIK3R1, BTK

NET-GE enrichment

Term New enriched termICP valueGenes
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (R-HSA-983695) -5.60.0CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
Regulation of signaling by CBL (R-HSA-912631) -8.520.012PIK3R1, BLNK
Regulation of actin dynamics for phagocytic cup formation (R-HSA-2029482) NEW5.230.002PIK3R1, CD79A, BTK, IGHM
Immune System (R-HSA-168256) -2.370.006CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) -4.620.0CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480) -5.070.003PIK3R1, CD79A, IGHM, BTK
Adaptive Immune System (R-HSA-1280218) -3.190.0CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.188IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
protein binding (GO:0005515) 0.468IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
receptor binding (GO:0005102) 2.435BTK, IGLL1, BLNK, PIK3R1, IGHM
signal transducer activity (GO:0004871) 2.284BLNK, CD79A, PIK3R1, CD79B
signaling receptor activity (GO:0038023) 2.492CD79A, CD79B
enzyme binding (GO:0019899) 2.272PIK3R1, BLNK
molecular transducer activity (GO:0060089) 2.322CD79A, CD79B
receptor activity (GO:0004872) 2.322CD79A, CD79B
immunoglobulin receptor binding (GO:0034987) 6.482IGLL1, IGHM
heterocyclic compound binding (GO:1901363) 1.062BTK, IGHM
cation binding (GO:0043169) 1.42BTK, IGHM
signaling adaptor activity (GO:0035591) 5.432PIK3R1, BLNK
receptor tyrosine kinase binding (GO:0030971) 5.772PIK3R1, BLNK
ion binding (GO:0043167) 1.362BTK, IGHM
transferase activity (GO:0016740) 1.952PIK3R1, BTK
protein tyrosine kinase binding (GO:1990782) 5.72PIK3R1, BLNK
kinase activity (GO:0016301) 2.932PIK3R1, BTK
protein kinase binding (GO:0019901) 3.442PIK3R1, BLNK
kinase binding (GO:0019900) 3.322PIK3R1, BLNK
antigen binding (GO:0003823) 5.022IGLL1, IGHM
binding, bridging (GO:0060090) 4.572PIK3R1, BLNK
protein binding, bridging (GO:0030674) 4.682PIK3R1, BLNK
catalytic activity (GO:0003824) 1.052PIK3R1, BTK
carbohydrate derivative binding (GO:0097367) 2.032BTK, IGHM
organic cyclic compound binding (GO:0097159) 1.052BTK, IGHM
transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068) 7.342PIK3R1, BLNK
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082PIK3R1, BTK
transmembrane signaling receptor activity (GO:0004888) 2.572CD79A, CD79B
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772PIK3R1, BTK
transmembrane receptor activity (GO:0099600) 2.532CD79A, CD79B

NET-GE enrichment

Term New enriched termICP valueGenes
signaling adaptor activity (GO:0035591) -5.430.02PIK3R1, BLNK
enzyme inhibitor activity (GO:0004857) NEW3.780.047PIK3R1, CD79A, BTK, CD79B
receptor tyrosine kinase binding (GO:0030971) -5.770.009PIK3R1, BLNK
transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068) -7.340.0PIK3R1, BLNK
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to stimulus (GO:0050896) 1.228IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
cellular process (GO:0009987) 0.268IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
immune system process (GO:0002376) 2.298IGLL1, PIK3R1, CD79B, LRRC8A, BLNK, CD79A, BTK, IGHM
biological regulation (GO:0065007) 0.398IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
single-organism cellular process (GO:0044763) 0.658IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
regulation of biological process (GO:0050789) 0.458IGLL1, PIK3R1, CD79B, LRRC8A, BLNK, CD79A, BTK, IGHM
single-organism process (GO:0044699) 0.488IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
positive regulation of response to stimulus (GO:0048584) 2.187IGLL1, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
regulation of response to stimulus (GO:0048583) 1.547IGLL1, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
regulation of cellular process (GO:0050794) 0.57IGLL1, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
signal transduction (GO:0007165) 1.287IGLL1, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
cell surface receptor signaling pathway (GO:0007166) 2.097IGLL1, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
positive regulation of biological process (GO:0048518) 1.27IGLL1, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
regulation of immune response (GO:0050776) 2.986IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.066IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
immune response-regulating signaling pathway (GO:0002764) 3.726IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
antigen receptor-mediated signaling pathway (GO:0050851) 4.436IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
response to stress (GO:0006950) 1.86IGLL1, PIK3R1, BTK, LRRC8A, BLNK, IGHM
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.966IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
lymphocyte activation (GO:0046649) 3.966LRRC8A, CD79B, BTK, PIK3R1, BLNK, CD79A
immune response (GO:0006955) 2.866IGLL1, CD79B, BTK, BLNK, CD79A, IGHM
cell activation (GO:0001775) 3.476LRRC8A, CD79B, BTK, BLNK, PIK3R1, CD79A
positive regulation of immune response (GO:0050778) 3.46IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
B cell activation (GO:0042113) 4.846LRRC8A, CD79B, BTK, BLNK, PIK3R1, CD79A
leukocyte activation (GO:0045321) 3.766LRRC8A, CD79B, BTK, BLNK, PIK3R1, CD79A
positive regulation of immune system process (GO:0002684) 2.966IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
immune response-activating signal transduction (GO:0002757) 3.86IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
regulation of immune system process (GO:0002682) 2.56IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
activation of immune response (GO:0002253) 3.676IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
cellular developmental process (GO:0048869) 1.826LRRC8A, CD79B, BTK, BLNK, PIK3R1, CD79A
B cell receptor signaling pathway (GO:0050853) 5.725BTK, IGLL1, CD79A, IGHM, CD79B
B cell differentiation (GO:0030183) 5.245CD79A, LRRC8A, PIK3R1, BLNK, CD79B
cell differentiation (GO:0030154) 2.145LRRC8A, CD79A, PIK3R1, CD79B, BLNK
lymphocyte differentiation (GO:0030098) 4.495LRRC8A, CD79A, PIK3R1, CD79B, BLNK
leukocyte differentiation (GO:0002521) 4.135LRRC8A, CD79A, PIK3R1, CD79B, BLNK
positive regulation of cellular process (GO:0048522) 1.35IGLL1, PIK3R1, IGHM, BTK, BLNK
primary metabolic process (GO:0044238) 0.694IGLL1, PIK3R1, BTK, IGHM
regulation of lymphocyte activation (GO:0051249) 3.734IGLL1, PIK3R1, BTK, IGHM
positive regulation of lymphocyte activation (GO:0051251) 4.074IGLL1, PIK3R1, BTK, IGHM
organic substance metabolic process (GO:0071704) 0.634IGLL1, PIK3R1, BTK, IGHM
protein metabolic process (GO:0019538) 1.454IGLL1, PIK3R1, BTK, IGHM
positive regulation of cell activation (GO:0050867) 3.974IGLL1, PIK3R1, BTK, IGHM
macromolecule metabolic process (GO:0043170) 0.834IGLL1, PIK3R1, IGHM, BTK
defense response (GO:0006952) 2.784IGLL1, BLNK, BTK, IGHM
regulation of leukocyte activation (GO:0002694) 3.64IGLL1, PIK3R1, BTK, IGHM
regulation of cell activation (GO:0050865) 3.534IGLL1, PIK3R1, BTK, IGHM
positive regulation of leukocyte activation (GO:0002696) 4.04IGLL1, PIK3R1, BTK, IGHM
adaptive immune response (GO:0002250) 4.434BTK, CD79A, IGHM, CD79B
metabolic process (GO:0008152) 0.584IGLL1, PIK3R1, BTK, IGHM
regulation of B cell activation (GO:0050864) 4.923IGLL1, BTK, IGHM
innate immune response (GO:0045087) 3.553IGLL1, BTK, IGHM
immune effector process (GO:0002252) 3.583IGLL1, PIK3R1, IGHM
cellular component organization (GO:0016043) 1.243IGLL1, LRRC8A, IGHM
positive regulation of B cell activation (GO:0050871) 5.273IGLL1, BTK, IGHM
enzyme linked receptor protein signaling pathway (GO:0007167) 3.243PIK3R1, BLNK, BTK
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.543PIK3R1, BLNK, BTK
intracellular signal transduction (GO:0035556) 2.393PIK3R1, BLNK, BTK
humoral immune response (GO:0006959) 4.593IGLL1, BLNK, IGHM
cellular component organization or biogenesis (GO:0071840) 1.223IGLL1, LRRC8A, IGHM
multi-organism process (GO:0051704) 2.653IGLL1, PIK3R1, IGHM
cellular homeostasis (GO:0019725) 3.232LRRC8A, PIK3R1
response to bacterium (GO:0009617) 4.182IGLL1, IGHM
regulation of primary metabolic process (GO:0080090) 1.082PIK3R1, BTK
regulation of metabolic process (GO:0019222) 1.022PIK3R1, BTK
regulation of transport (GO:0051049) 2.242LRRC8A, PIK3R1
apoptotic signaling pathway (GO:0097190) 4.122PIK3R1, BTK
homeostatic process (GO:0042592) 2.612LRRC8A, PIK3R1
membrane organization (GO:0061024) 3.042IGLL1, IGHM
cellular metabolic process (GO:0044237) 0.692PIK3R1, BTK
regulation of signaling (GO:0023051) 1.722PIK3R1, BLNK
regulation of cell differentiation (GO:0045595) 2.422PIK3R1, BTK
positive regulation of cell communication (GO:0010647) 2.412PIK3R1, BLNK
regulation of cell death (GO:0010941) 2.432PIK3R1, BTK
regulation of apoptotic process (GO:0042981) 2.52PIK3R1, BTK
regulation of hemopoiesis (GO:1903706) 4.02PIK3R1, BTK
cellular protein metabolic process (GO:0044267) 1.632PIK3R1, BTK
regulation of localization (GO:0032879) 1.942LRRC8A, PIK3R1
regulation of cell communication (GO:0010646) 1.732PIK3R1, BLNK
response to external biotic stimulus (GO:0043207) 3.132IGLL1, IGHM
regulation of cytokine production (GO:0001817) 3.42PIK3R1, BTK
regulation of signal transduction (GO:0009966) 1.842PIK3R1, BLNK
positive regulation of signal transduction (GO:0009967) 2.52PIK3R1, BLNK
positive regulation of multicellular organismal process (GO:0051240) 2.492PIK3R1, BTK
negative regulation of multicellular organismal process (GO:0051241) 2.842PIK3R1, BTK
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462PIK3R1, BTK
regulation of leukocyte differentiation (GO:1902105) 4.262PIK3R1, BTK
protein activation cascade (GO:0072376) 5.212IGLL1, IGHM
regulation of developmental process (GO:0050793) 2.12PIK3R1, BTK
regulation of programmed cell death (GO:0043067) 2.492PIK3R1, BTK
phosphorylation (GO:0016310) 2.632PIK3R1, BTK
response to abiotic stimulus (GO:0009628) 2.82LRRC8A, PIK3R1
negative regulation of biological process (GO:0048519) 1.332PIK3R1, BTK
regulation of molecular function (GO:0065009) 1.782PIK3R1, BTK
regulation of biological quality (GO:0065008) 1.682LRRC8A, PIK3R1
regulation of gene expression (GO:0010468) 1.372PIK3R1, BTK
cell recognition (GO:0008037) 4.732IGLL1, IGHM
protein phosphorylation (GO:0006468) 2.892PIK3R1, BTK
organic substance biosynthetic process (GO:1901576) 1.342PIK3R1, BTK
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432PIK3R1, BTK
regulation of cellular metabolic process (GO:0031323) 1.072PIK3R1, BTK
transport (GO:0006810) 1.512LRRC8A, PIK3R1
regulation of biosynthetic process (GO:0009889) 1.372PIK3R1, BTK
cellular protein modification process (GO:0006464) 1.792PIK3R1, BTK
phagocytosis, engulfment (GO:0006911) 6.092IGLL1, IGHM
regulation of cellular biosynthetic process (GO:0031326) 1.382PIK3R1, BTK
macromolecule modification (GO:0043412) 1.732PIK3R1, BTK
protein modification process (GO:0036211) 1.792PIK3R1, BTK
complement activation (GO:0006956) 5.492IGLL1, IGHM
regulation of nucleic acid-templated transcription (GO:1903506) 1.552PIK3R1, BTK
regulation of multicellular organismal process (GO:0051239) 1.872PIK3R1, BTK
regulation of RNA biosynthetic process (GO:2001141) 1.552PIK3R1, BTK
phagocytosis, recognition (GO:0006910) 6.22IGLL1, IGHM
complement activation, classical pathway (GO:0006958) 5.742IGLL1, IGHM
establishment of localization (GO:0051234) 1.482LRRC8A, PIK3R1
response to other organism (GO:0051707) 3.482IGLL1, IGHM
localization (GO:0051179) 1.42LRRC8A, PIK3R1
Fc receptor signaling pathway (GO:0038093) 4.452PIK3R1, BTK
positive regulation of signaling (GO:0023056) 2.412PIK3R1, BLNK
Fc-epsilon receptor signaling pathway (GO:0038095) 4.842PIK3R1, BTK
response to biotic stimulus (GO:0009607) 3.092IGLL1, IGHM
cellular macromolecule metabolic process (GO:0044260) 0.932PIK3R1, BTK
response to external stimulus (GO:0009605) 2.552IGLL1, IGHM
cellular biosynthetic process (GO:0044249) 1.372PIK3R1, BTK
regulation of macromolecule metabolic process (GO:0060255) 1.082PIK3R1, BTK
regulation of response to stress (GO:0080134) 2.532PIK3R1, BTK
regulation of RNA metabolic process (GO:0051252) 1.522PIK3R1, BTK
biosynthetic process (GO:0009058) 1.322PIK3R1, BTK
membrane invagination (GO:0010324) 5.652IGLL1, IGHM
defense response to bacterium (GO:0042742) 4.312IGLL1, IGHM
regulation of transcription, DNA-templated (GO:0006355) 1.562PIK3R1, BTK
phosphate-containing compound metabolic process (GO:0006796) 2.162PIK3R1, BTK
regulation of macromolecule biosynthetic process (GO:0010556) 1.432PIK3R1, BTK
regulation of multicellular organismal development (GO:2000026) 2.312PIK3R1, BTK
phosphorus metabolic process (GO:0006793) 2.152PIK3R1, BTK
defense response to other organism (GO:0098542) 3.752IGLL1, IGHM
regulation of nitrogen compound metabolic process (GO:0051171) 1.362PIK3R1, BTK

NET-GE enrichment

Term New enriched termICP valueGenes
antigen receptor-mediated signaling pathway (GO:0050851) -4.430.0CD79A, BLNK, PIK3R1, BTK, CD79B
immune response-regulating signaling pathway (GO:0002764) -3.720.021CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
B cell receptor signaling pathway (GO:0050853) -5.720.0CD79A, BTK, CD79B
positive regulation of innate immune response (GO:0045089) NEW4.220.031PIK3R1, BTK, CD79B, IGHM
lymphocyte differentiation (GO:0030098) -4.490.002LRRC8A, CD79A, PIK3R1, BTK, BLNK
B cell differentiation (GO:0030183) -5.240.0BLNK, CD79A, LRRC8A, PIK3R1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.001CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
immune response-activating cell surface receptor signaling pathway (GO:0002429) -4.060.003CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
positive regulation of immune response (GO:0050778) -3.40.006CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
B cell activation (GO:0042113) -4.840.0BTK, BLNK, CD79A, LRRC8A, PIK3R1
immune system process (GO:0002376) -2.290.0IGLL1, PIK3R1, CD79B, LRRC8A, BLNK, CD79A, BTK, IGHM
leukocyte activation (GO:0045321) -3.760.0CD79A, BLNK, PIK3R1, LRRC8A, BTK
cell activation (GO:0001775) -3.470.001BTK, BLNK, CD79A, LRRC8A, PIK3R1
lymphocyte activation (GO:0046649) -3.960.0LRRC8A, CD79A, PIK3R1, BTK, BLNK
activation of immune response (GO:0002253) -3.670.013CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
immune response (GO:0006955) -2.860.001IGLL1, CD79B, BTK, BLNK, PIK3R1, IGHM
humoral immune response (GO:0006959) -4.590.0IGLL1, BTK, BLNK, PIK3R1, CD79A, IGHM
leukocyte differentiation (GO:0002521) -4.130.001LRRC8A, CD79A, PIK3R1, BTK, BLNK
immune response-activating signal transduction (GO:0002757) -3.80.009CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane (GO:0016020) 0.688IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
cell part (GO:0044464) 0.118IGLL1, PIK3R1, CD79B, LRRC8A, BLNK, CD79A, BTK, IGHM
membrane part (GO:0044425) 0.957IGLL1, CD79B, BTK, LRRC8A, PIK3R1, CD79A, IGHM
plasma membrane (GO:0005886) 1.397LRRC8A, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
protein complex (GO:0043234) 1.516IGLL1, CD79B, LRRC8A, PIK3R1, CD79A, IGHM
macromolecular complex (GO:0032991) 1.356IGLL1, CD79B, LRRC8A, PIK3R1, CD79A, IGHM
membrane-bounded organelle (GO:0043227) 0.476IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
organelle (GO:0043226) 0.46IGLL1, CD79B, BTK, PIK3R1, CD79A, IGHM
cytoplasm (GO:0005737) 1.015CD79A, BLNK, PIK3R1, BTK, CD79B
intracellular part (GO:0044424) 0.285PIK3R1, CD79A, BTK, CD79B, BLNK
cytoplasmic part (GO:0044444) 0.825PIK3R1, CD79A, BTK, CD79B, BLNK
plasma membrane part (GO:0044459) 1.955BTK, IGLL1, CD79A, IGHM, CD79B
external side of plasma membrane (GO:0009897) 4.464IGLL1, CD79A, IGHM, CD79B
vesicle (GO:0031982) 1.644BTK, IGLL1, IGHM, CD79B
integral component of membrane (GO:0016021) 1.144LRRC8A, CD79A, IGHM, CD79B
membrane protein complex (GO:0098796) 2.844LRRC8A, CD79A, PIK3R1, CD79B
intracellular organelle (GO:0043229) 0.514PIK3R1, CD79A, BTK, CD79B
side of membrane (GO:0098552) 4.224IGLL1, CD79A, IGHM, CD79B
immunoglobulin complex (GO:0019814) 6.584IGLL1, CD79A, IGHM, CD79B
intrinsic component of membrane (GO:0031224) 1.134LRRC8A, CD79A, IGHM, CD79B
intracellular membrane-bounded organelle (GO:0043231) 0.64PIK3R1, CD79A, BTK, CD79B
extracellular organelle (GO:0043230) 1.893IGLL1, IGHM, CD79B
extracellular exosome (GO:0070062) 1.893IGLL1, IGHM, CD79B
cytosol (GO:0005829) 1.683PIK3R1, BLNK, BTK
membrane-bounded vesicle (GO:0031988) 1.713IGLL1, IGHM, CD79B
extracellular vesicle (GO:1903561) 1.893IGLL1, IGHM, CD79B
extracellular region part (GO:0044421) 1.573IGLL1, IGHM, CD79B
receptor complex (GO:0043235) 4.012CD79A, CD79B
membrane raft (GO:0045121) 4.182CD79A, BTK
cell surface (GO:0009986) 3.442LRRC8A, IGHM
membrane region (GO:0098589) 3.952CD79A, BTK
plasma membrane receptor complex (GO:0098802) 4.632CD79A, CD79B
blood microparticle (GO:0072562) 4.882IGLL1, IGHM
plasma membrane protein complex (GO:0098797) 3.552CD79A, CD79B
extracellular region (GO:0005576) 2.182IGLL1, IGHM
integral component of plasma membrane (GO:0005887) 2.572CD79A, CD79B
immunoglobulin complex, circulating (GO:0042571) 6.712IGLL1, IGHM
B cell receptor complex (GO:0019815) 8.422CD79A, CD79B
membrane microdomain (GO:0098857) 4.172CD79A, BTK
intrinsic component of plasma membrane (GO:0031226) 2.532CD79A, CD79B
nucleus (GO:0005634) 1.072PIK3R1, BTK
organelle part (GO:0044422) 0.792PIK3R1, CD79B
intracellular organelle part (GO:0044446) 0.812PIK3R1, CD79B

NET-GE enrichment

Term New enriched termICP valueGenes
external side of plasma membrane (GO:0009897) -4.460.017PIK3R1, CD79A, BTK, CD79B
membrane (GO:0016020) -0.680.025IGLL1, BTK, CD79B, LRRC8A, PIK3R1, CD79A, IGHM, BLNK
extracellular space (GO:0005615) NEW2.630.01IGLL1, CD79B, BTK, BLNK, PIK3R1, CD79A, IGHM
receptor complex (GO:0043235) -4.010.035PIK3R1, CD79A, BTK, CD79B
cell surface (GO:0009986) -3.440.002IGLL1, BTK, LRRC8A, PIK3R1, CD79A, IGHM
plasma membrane (GO:0005886) -1.390.006LRRC8A, CD79B, BTK, PIK3R1, BLNK, CD79A, IGHM
side of membrane (GO:0098552) -4.220.043PIK3R1, CD79A, BTK, CD79B
B cell receptor complex (GO:0019815) -8.420.0CD79A, CD79B
immunoglobulin complex (GO:0019814) -6.580.0BTK, CD79A, IGHM, CD79B