Disease table of EPILEPSY, GENERALIZED, WITH FEBRILE SEIZURES PLUS OMIM ID: PS604233

Gene-disease associations table

GeneAssociated with EPILEPSY, GENERALIZED, WITH FEBRILE SEIZURES PLUS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
STX1BClinVar, OMIM, HUMSAVARHGNC link16p11.21PS604233
GABRG2ClinVar, OMIM, HUMSAVARHGNC link5q343PS121210, 607681, PS604233
SCN9AClinVar, OMIM, HUMSAVARHGNC link2q24.36PS121210, 243000, PS308350, 167400, PS604233, 133020
SCN1BClinVar, OMIM, HUMSAVARHGNC link19q13.114PS601144, PS608583, 115000, PS604233
SCN1AClinVar, OMIM, HUMSAVARHGNC link2q24.35606369, PS604233, 609634, PS308350, PS121210
GABRDClinVar, OMIM, HUMSAVARHGNC link1p36.331PS604233

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 1382SCN9A, SCN1A
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
2q24.32SCN9A, SCN1A
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
2q242SCN9A, SCN1A
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
2q22SCN9A, SCN1A
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
2q2SCN9A, SCN1A
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
22SCN9A, SCN1A
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SCN9AYES1USF10
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
STX1BGABRG2No-1NSF
STX1BGABRDNo-1NSF
GABRG2GABRDNo-8CLCN2, GPHN, TRAK2, GABARAP, NSF, GABARAPL2, PLCL1, GABARAPL1
SCN9ASCN1BYesbinding1SCN2B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Morphine addictionhsa050326.152GABRD, GABRG2
Nicotine addictionhsa050337.382GABRD, GABRG2
Retrograde endocannabinoid signalinghsa047236.032GABRD, GABRG2
Neuroactive ligand-receptor interactionhsa040804.582GABRD, GABRG2
GABAergic synapsehsa047276.242GABRD, GABRG2

NET-GE enrichment

Term New enriched termICP valueGenes
Morphine addiction (hsa05032) -6.150.036GABRD, GABRG2
Nervous systemNEW3.770.036GABRD, SCN1A, GABRG2, STX1B
Retrograde endocannabinoid signaling (hsa04723) -6.030.043GABRD, GABRG2
GABAergic synapse (hsa04727) -6.240.032GABRD, GABRG2
Nicotine addiction (hsa05033) -7.380.018GABRD, GABRG2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Developmental BiologyR-HSA-12667383.484SCN9A, SCN1A, STX1B, SCN1B
Axon guidanceR-HSA-4224753.933SCN9A, SCN1A, SCN1B
Interaction between L1 and AnkyrinsR-HSA-4450958.033SCN9A, SCN1A, SCN1B
L1CAM interactionsR-HSA-3737606.193SCN9A, SCN1A, SCN1B

NET-GE enrichment

Term New enriched termICP valueGenes
Axon guidance (R-HSA-422475) -3.930.048SCN9A, SCN1A, SCN1B
Interaction between L1 and Ankyrins (R-HSA-445095) -8.030.0SCN9A, SCN1A, SCN1B
L1CAM interactions (R-HSA-373760) -6.190.002SCN9A, SCN1A, SCN1B
Developmental Biology (R-HSA-1266738) -3.480.006SCN1A, STX1B, SCN9A, SCN1B
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
substrate-specific transmembrane transporter activity (GO:0022891) 2.95GABRD, SCN1A, GABRG2, SCN9A, SCN1B
substrate-specific transporter activity (GO:0022892) 2.725GABRD, SCN9A, GABRG2, SCN1A, SCN1B
transporter activity (GO:0005215) 2.575GABRD, SCN9A, GABRG2, SCN1A, SCN1B
ion channel activity (GO:0005216) 3.715GABRD, SCN1A, GABRG2, SCN9A, SCN1B
ion transmembrane transporter activity (GO:0015075) 3.045GABRD, SCN1A, GABRG2, SCN9A, SCN1B
transmembrane transporter activity (GO:0022857) 2.825GABRD, SCN1A, GABRG2, SCN9A, SCN1B
channel activity (GO:0015267) 3.65GABRD, SCN9A, GABRG2, SCN1A, SCN1B
binding (GO:0005488) 0.185GABRD, SCN9A, GABRG2, STX1B, SCN1A
passive transmembrane transporter activity (GO:0022803) 3.65GABRD, SCN9A, GABRG2, SCN1A, SCN1B
substrate-specific channel activity (GO:0022838) 3.675GABRD, SCN1A, GABRG2, SCN9A, SCN1B
gated channel activity (GO:0022836) 3.965GABRD, SCN1A, GABRG2, SCN9A, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890) 3.493SCN9A, SCN1A, SCN1B
sodium channel activity (GO:0005272) 6.133SCN9A, SCN1A, SCN1B
sodium ion transmembrane transporter activity (GO:0015081) 4.833SCN1A, SCN9A, SCN1B
cation transmembrane transporter activity (GO:0008324) 3.323SCN9A, SCN1A, SCN1B
voltage-gated channel activity (GO:0022832) 4.493SCN9A, SCN1A, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.873SCN9A, SCN1A, SCN1B
protein binding (GO:0005515) 0.463GABRD, GABRG2, STX1B
voltage-gated sodium channel activity (GO:0005248) 6.743SCN1A, SCN9A, SCN1B
cation channel activity (GO:0005261) 4.043SCN9A, SCN1A, SCN1B
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030) 6.743SCN9A, SCN1A, SCN1B
voltage-gated ion channel activity (GO:0005244) 4.493SCN1A, SCN9A, SCN1B
metal ion transmembrane transporter activity (GO:0046873) 3.713SCN9A, SCN1A, SCN1B
cation binding (GO:0043169) 1.42SCN1A, SCN9A
metal ion binding (GO:0046872) 1.412SCN9A, SCN1A
signaling receptor activity (GO:0038023) 2.492GABRD, GABRG2
inorganic anion transmembrane transporter activity (GO:0015103) 4.872GABRD, GABRG2
sodium ion binding (GO:0031402) 7.12SCN9A, SCN1A
extracellular ligand-gated ion channel activity (GO:0005230) 5.422GABRD, GABRG2
alkali metal ion binding (GO:0031420) 6.692SCN1A, SCN9A
ligand-gated ion channel activity (GO:0015276) 4.82GABRD, GABRG2
ion binding (GO:0043167) 1.362SCN9A, SCN1A
GABA receptor activity (GO:0016917) 6.652GABRD, GABRG2
molecular transducer activity (GO:0060089) 2.322GABRD, GABRG2
transmembrane signaling receptor activity (GO:0004888) 2.572GABRD, GABRG2
anion transmembrane transporter activity (GO:0008509) 4.432GABRD, GABRG2
receptor activity (GO:0004872) 2.322GABRD, GABRG2
signal transducer activity (GO:0004871) 2.282GABRD, GABRG2
ligand-gated channel activity (GO:0022834) 4.82GABRD, GABRG2
GABA-A receptor activity (GO:0004890) 6.792GABRD, GABRG2
anion channel activity (GO:0005253) 5.232GABRD, GABRG2
chloride channel activity (GO:0005254) 5.362GABRD, GABRG2
chloride transmembrane transporter activity (GO:0015108) 5.242GABRD, GABRG2
transmembrane receptor activity (GO:0099600) 2.532GABRD, GABRG2

NET-GE enrichment

Term New enriched termICP valueGenes
cation channel activity (GO:0005261) -4.040.005SCN1A, SCN9A, SCN1B
GABA receptor activity (GO:0016917) -6.650.004GABRD, GABRG2
sodium ion transmembrane transporter activity (GO:0015081) -4.830.007SCN1A, SCN9A, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077) -3.870.01SCN1A, SCN9A, SCN1B
ligand-gated ion channel activity (GO:0015276) -4.80.014GABRD, GABRG2, STX1B
voltage-gated cation channel activity (GO:0022843) NEW4.830.001SCN1A, SCN9A, SCN1B
inorganic anion transmembrane transporter activity (GO:0015103) -4.870.04GABRD, GABRG2
passive transmembrane transporter activity (GO:0022803) -3.60.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
metal ion transmembrane transporter activity (GO:0046873) -3.710.014SCN9A, SCN1A, SCN1B
anion channel activity (GO:0005253) -5.230.017GABRD, GABRG2
chloride channel activity (GO:0005254) -5.360.014GABRD, GABRG2
ion channel activity (GO:0005216) -3.710.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
sodium channel activity (GO:0005272) -6.130.0SCN9A, SCN1A, SCN1B
transporter activity (GO:0005215) -2.570.002STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
extracellular ligand-gated ion channel activity (GO:0005230) -5.420.001GABRD, GABRG2, STX1B
voltage-gated sodium channel activity (GO:0005248) -6.740.0SCN1A, SCN9A, SCN1B
substrate-specific transporter activity (GO:0022892) -2.720.001STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
GABA-A receptor activity (GO:0004890) -6.790.003GABRD, GABRG2
substrate-specific transmembrane transporter activity (GO:0022891) -2.90.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890) -3.490.028SCN9A, SCN1A, SCN1B
substrate-specific channel activity (GO:0022838) -3.670.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
chloride transmembrane transporter activity (GO:0015108) -5.240.02GABRD, GABRG2
ion transmembrane transporter activity (GO:0015075) -3.040.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
voltage-gated channel activity (GO:0022832) -4.490.019SCN9A, SCN1A, SCN1B
transmembrane transporter activity (GO:0022857) -2.820.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
channel activity (GO:0015267) -3.60.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
gated channel activity (GO:0022836) -3.960.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
ligand-gated channel activity (GO:0022834) -4.80.014GABRD, GABRG2, STX1B
voltage-gated ion channel activity (GO:0005244) -4.490.019SCN1A, SCN9A, SCN1B
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
transport (GO:0006810) 1.516STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
localization (GO:0051179) 1.46STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
biological regulation (GO:0065007) 0.396STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
establishment of localization (GO:0051234) 1.486STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
regulation of biological process (GO:0050789) 0.456STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
single-organism process (GO:0044699) 0.486STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
ion transport (GO:0006811) 2.665GABRD, SCN1A, GABRG2, SCN9A, SCN1B
cellular process (GO:0009987) 0.265GABRD, SCN1A, GABRG2, STX1B, SCN1B
regulation of cellular process (GO:0050794) 0.55GABRD, SCN1A, GABRG2, STX1B, SCN1B
ion transmembrane transport (GO:0034220) 3.085GABRD, SCN9A, GABRG2, SCN1A, SCN1B
inorganic ion transmembrane transport (GO:0098660) 3.385GABRD, SCN9A, GABRG2, SCN1A, SCN1B
transmembrane transport (GO:0055085) 2.725GABRD, SCN9A, GABRG2, SCN1A, SCN1B
regulation of membrane potential (GO:0042391) 3.894SCN9A, SCN1A, STX1B, SCN1B
multicellular organismal process (GO:0032501) 1.454SCN1A, GABRG2, SCN9A, SCN1B
regulation of biological quality (GO:0065008) 1.684SCN1A, STX1B, SCN9A, SCN1B
single-multicellular organism process (GO:0044707) 1.784SCN9A, GABRG2, SCN1A, SCN1B
regulation of transport (GO:0051049) 2.244SCN9A, SCN1A, STX1B, SCN1B
single-organism cellular process (GO:0044763) 0.654GABRD, GABRG2, STX1B, SCN1B
regulation of localization (GO:0032879) 1.944SCN1A, STX1B, SCN9A, SCN1B
behavior (GO:0007610) 3.473SCN1A, GABRG2, SCN9A
membrane depolarization (GO:0051899) 5.623SCN9A, SCN1A, SCN1B
signaling (GO:0023052) 3.253GABRD, GABRG2, SCN1B
cell communication (GO:0007154) 3.043GABRD, GABRG2, SCN1B
action potential (GO:0001508) 5.423SCN1A, SCN9A, SCN1B
regulation of ion transmembrane transport (GO:0034765) 3.773SCN9A, SCN1A, SCN1B
regulation of transmembrane transport (GO:0034762) 3.743SCN9A, SCN1A, SCN1B
sodium ion transmembrane transport (GO:0035725) 5.233SCN1A, SCN9A, SCN1B
inorganic cation transmembrane transport (GO:0098662) 3.553SCN9A, SCN1A, SCN1B
cation transport (GO:0006812) 3.113SCN9A, SCN1A, SCN1B
monovalent inorganic cation transport (GO:0015672) 3.743SCN1A, SCN9A, SCN1B
neurological system process (GO:0050877) 2.643SCN9A, SCN1A, SCN1B
sodium ion transport (GO:0006814) 4.753SCN1A, SCN9A, SCN1B
response to chemical (GO:0042221) 1.983GABRG2, SCN9A, SCN1B
metal ion transport (GO:0030001) 3.363SCN9A, SCN1A, SCN1B
chemical synaptic transmission (GO:0007268) 3.983GABRD, GABRG2, SCN1B
cell-cell signaling (GO:0007267) 3.353GABRD, GABRG2, SCN1B
regulation of postsynaptic membrane potential (GO:0060078) 5.723SCN1A, SCN9A, SCN1B
membrane depolarization during action potential (GO:0086010) 6.073SCN1A, SCN9A, SCN1B
system process (GO:0003008) 2.33SCN1A, SCN9A, SCN1B
single organism signaling (GO:0044700) 3.253GABRD, GABRG2, SCN1B
single-organism behavior (GO:0044708) 3.793SCN9A, GABRG2, SCN1A
response to stimulus (GO:0050896) 1.223GABRG2, SCN9A, SCN1B
anterograde trans-synaptic signaling (GO:0098916) 3.983GABRD, GABRG2, SCN1B
regulation of ion transport (GO:0043269) 3.43SCN1A, SCN9A, SCN1B
cation transmembrane transport (GO:0098655) 3.433SCN9A, SCN1A, SCN1B
synaptic signaling (GO:0099536) 3.983GABRD, GABRG2, SCN1B
trans-synaptic signaling (GO:0099537) 3.983GABRD, GABRG2, SCN1B
adult behavior (GO:0030534) 4.792GABRG2, SCN1A
neuronal action potential propagation (GO:0019227) 7.652SCN1A, SCN1B
positive regulation of transport (GO:0051050) 2.92STX1B, SCN1B
neuronal action potential (GO:0019228) 6.42SCN1A, SCN9A
regulation of response to stimulus (GO:0048583) 1.542SCN1A, STX1B
regulation of cellular component organization (GO:0051128) 2.012STX1B, SCN1B
post-embryonic development (GO:0009791) 5.352GABRG2, SCN9A
anion transmembrane transport (GO:0098656) 4.512GABRD, GABRG2
anion transport (GO:0006820) 3.712GABRD, GABRG2
chloride transport (GO:0006821) 5.132GABRD, GABRG2
signal transduction (GO:0007165) 1.282GABRD, GABRG2
inorganic anion transmembrane transport (GO:0098661) 5.042GABRD, GABRG2
chloride transmembrane transport (GO:1902476) 5.222GABRD, GABRG2
positive regulation of biological process (GO:0048518) 1.22STX1B, SCN1B
inorganic anion transport (GO:0015698) 4.772GABRD, GABRG2
action potential propagation (GO:0098870) 7.652SCN1A, SCN1B
response to toxic substance (GO:0009636) 4.882SCN9A, SCN1B
positive regulation of cellular process (GO:0048522) 1.32STX1B, SCN1B

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of membrane potential (GO:0042391) -3.890.01SCN1A, STX1B, SCN9A, SCN1B
neuronal action potential propagation (GO:0019227) -7.650.0SCN1A, SCN1B
neuronal action potential (GO:0019228) -6.40.005SCN9A, SCN1A
post-embryonic development (GO:0009791) -5.350.047GABRG2, SCN9A
membrane depolarization (GO:0051899) -5.620.017SCN1A, SCN9A, SCN1B
signaling (GO:0023052) -3.250.006GABRD, GABRG2, STX1B, SCN1B
action potential (GO:0001508) -5.420.0SCN1A, SCN9A, SCN1B
regulation of ion transmembrane transport (GO:0034765) -3.770.015SCN1A, SCN9A, SCN1B
regulation of transmembrane transport (GO:0034762) -3.740.017SCN1A, SCN9A, SCN1B
membrane depolarization during action potential (GO:0086010) -6.070.0SCN9A, SCN1A, SCN1B
cardiac muscle cell action potential (GO:0086001) NEW6.330.022SCN1A, SCN1B
cardiac muscle cell action potential involved in contraction (GO:0086002) NEW6.470.022SCN1A, SCN1B
transmembrane transport (GO:0055085) -2.720.002STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
sodium ion transmembrane transport (GO:0035725) -5.230.0SCN9A, SCN1A, SCN1B
inorganic ion transmembrane transport (GO:0098660) -3.380.0GABRD, SCN1A, GABRG2, SCN9A, SCN1B
monovalent inorganic cation transport (GO:0015672) -3.740.034SCN1A, SCN9A, SCN1B
cardiac conduction (GO:0061337) NEW5.540.021SCN1A, SCN1B
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) NEW6.840.003SCN1A, SCN1B
ion transport (GO:0006811) -2.660.003STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
transport (GO:0006810) -1.510.01STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
sodium ion transport (GO:0006814) -4.750.025SCN1A, SCN9A, SCN1B
ion transmembrane transport (GO:0034220) -3.080.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
single-organism transport (GO:0044765) NEW2.180.002STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
synaptic transmission (GO:0007268) -3.980.001GABRD, GABRG2, STX1B, SCN1B
cell-cell signaling (GO:0007267) -3.350.005GABRD, GABRG2, STX1B, SCN1B
cell communication (GO:0007154) -3.040.011GABRD, GABRG2, STX1B, SCN1B
establishment of localization (GO:0051234) -1.480.012STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
localization (GO:0051179) -1.40.019STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
single organism signaling (GO:0044700) -3.250.006GABRD, GABRG2, STX1B, SCN1B
single-organism behavior (GO:0044708) -3.790.023SCN9A, GABRG2, SCN1A
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.516STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
macromolecular complex (GO:0032991) 1.356STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
integral component of membrane (GO:0016021) 1.146STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
membrane (GO:0016020) 0.686STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
cell part (GO:0044464) 0.116STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
membrane protein complex (GO:0098796) 2.846STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
plasma membrane (GO:0005886) 1.396STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
membrane part (GO:0044425) 0.956STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
intrinsic component of membrane (GO:0031224) 1.136STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
transmembrane transporter complex (GO:1902495) 4.065GABRD, SCN1A, GABRG2, SCN9A, SCN1B
ion channel complex (GO:0034702) 4.185GABRD, SCN1A, GABRG2, SCN9A, SCN1B
transporter complex (GO:1990351) 4.045GABRD, SCN1A, GABRG2, SCN9A, SCN1B
plasma membrane part (GO:0044459) 1.955GABRD, SCN1A, GABRG2, SCN9A, SCN1B
neuron part (GO:0097458) 2.644SCN1A, GABRG2, STX1B, SCN1B
cell junction (GO:0030054) 2.754GABRD, GABRG2, SCN1A, SCN1B
plasma membrane protein complex (GO:0098797) 3.553SCN1A, SCN9A, SCN1B
cell projection part (GO:0044463) 2.973GABRG2, SCN1A, SCN1B
sodium channel complex (GO:0034706) 6.973SCN1A, SCN9A, SCN1B
synapse part (GO:0044456) 3.423GABRD, GABRG2, STX1B
cation channel complex (GO:0034703) 4.693SCN9A, SCN1A, SCN1B
integral component of plasma membrane (GO:0005887) 2.573GABRD, GABRG2, SCN9A
intracellular part (GO:0044424) 0.283SCN1A, GABRG2, STX1B
cell projection (GO:0042995) 2.473SCN9A, GABRG2, SCN1A
intrinsic component of plasma membrane (GO:0031226) 2.533GABRD, GABRG2, SCN9A
voltage-gated sodium channel complex (GO:0001518) 7.163SCN9A, SCN1A, SCN1B
synaptic membrane (GO:0097060) 4.222GABRD, GABRG2
plasma membrane region (GO:0098590) 2.972GABRD, GABRG2
GABA receptor complex (GO:1902710) 6.912GABRD, GABRG2
GABA-A receptor complex (GO:1902711) 6.912GABRD, GABRG2
cell-cell junction (GO:0005911) 3.852SCN1A, SCN1B
receptor complex (GO:0043235) 4.012GABRD, GABRG2
T-tubule (GO:0030315) 6.092SCN1A, SCN1B
cell-cell contact zone (GO:0044291) 5.692SCN1A, SCN1B
cytoplasm (GO:0005737) 1.012GABRG2, STX1B
postsynaptic membrane (GO:0045211) 4.472GABRD, GABRG2
axon (GO:0030424) 4.152GABRG2, SCN1A
intercalated disc (GO:0014704) 5.932SCN1A, SCN1B
chloride channel complex (GO:0034707) 5.892GABRD, GABRG2
cytoplasmic part (GO:0044444) 0.822SCN1A, STX1B
synapse (GO:0045202) 3.582GABRD, GABRG2
neuron projection (GO:0043005) 3.122GABRG2, SCN1A
axon part (GO:0033267) 4.42SCN1A, SCN1B
node of Ranvier (GO:0033268) 7.092SCN1A, SCN1B
organelle part (GO:0044422) 0.792SCN1A, STX1B

NET-GE enrichment

Term New enriched termICP valueGenes
intercalated disc (GO:0014704) -5.930.003SCN1A, SCN1B
transmembrane transporter complex (GO:1902495) -4.060.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
axon initial segment (GO:0043194) NEW7.320.001SCN1A, SCN1B
T-tubule (GO:0030315) -6.090.003SCN1A, SCN1B
cell-cell contact zone (GO:0044291) -5.690.004SCN1A, SCN1B
transporter complex (GO:1990351) -4.040.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
sodium channel complex (GO:0034706) -6.970.0SCN1A, SCN9A, SCN1B
chloride channel complex (GO:0034707) -5.890.006GABRD, GABRG2
ion channel complex (GO:0034702) -4.180.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
cation channel complex (GO:0034703) -4.690.005SCN9A, SCN1A, SCN1B
axon part (GO:0033267) -4.40.043SCN1A, SCN1B
node of Ranvier (GO:0033268) -7.090.001SCN1A, SCN1B
plasma membrane part (GO:0044459) -1.950.0STX1B, GABRD, SCN9A, SCN1A, GABRG2, SCN1B
cell junction (GO:0030054) -2.750.008GABRD, GABRG2, SCN1A, SCN1B
voltage-gated sodium channel complex (GO:0001518) -7.160.0SCN9A, SCN1A, SCN1B