Disease table of EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE OMIM ID: PS308350

Gene-disease associations table

Gene	Associated with EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
NECAP1	ClinVar, OMIM	HGNC link	12p13.31	1	PS308350
PIGA	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp22.2	3	PS300818, PS614080, PS308350
GNAO1	ClinVar, OMIM, HUMSAVAR	HGNC link	16q13	1	PS308350
EEF1A2	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.33	2	PS156200, PS308350
DOCK7	ClinVar, OMIM	HGNC link	1p31.3	1	PS308350
SCN9A	OMIM	HGNC link	2q24.3	6	PS121210, 243000, PS308350, 167400, PS604233, 133020
STXBP1	ClinVar, OMIM, HUMSAVAR	HGNC link	9q34.11	1	PS308350
DNM1	ClinVar, OMIM, HUMSAVAR	HGNC link	9q34.11	1	PS308350
KCNA2	ClinVar, OMIM, HUMSAVAR	HGNC link	1p13.3	1	PS308350
GRIN2B	ClinVar, OMIM, HUMSAVAR	HGNC link	12p13.1	2	PS156200, PS308350
SIK1	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.3	1	PS308350
ARHGEF9	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq11.2	1	PS308350
CDKL5	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp22.13	2	PS308350, 105830
GABRA1	ClinVar, OMIM, HUMSAVAR	HGNC link	5q34	2	PS308350, 611136
SZT2	ClinVar, OMIM	HGNC link	1p34.2	1	PS308350
SLC12A5	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.12	2	PS308350, 616685
SCN2A	ClinVar, OMIM, HUMSAVAR	HGNC link	2q24.3	2	PS308350, PS601764
SLC35A2	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp11.23	2	PS212066, PS308350
SPTAN1	ClinVar, OMIM	HGNC link	9q34.11	1	PS308350
TBC1D24	ClinVar, OMIM, HUMSAVAR	HGNC link	16p13.3	6	PS220290, 605021, PS124900, PS308350, PS254800, 220500
ST3GAL3	ClinVar, OMIM, HUMSAVAR	HGNC link	1p34.1	2	PS308350, PS249500
PLCB1	OMIM	HGNC link	20p12.3	1	PS308350
PNKP	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.33	2	PS308350, 616267
KCNQ2	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.33	2	PS308350, PS121200
SCN1A	ClinVar, OMIM, HUMSAVAR	HGNC link	2q24.3	5	606369, PS604233, 609634, PS308350, PS121210
SCN8A	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.13	2	PS308350, 614306
SLC13A5	ClinVar, OMIM	HGNC link	17p13.1	1	PS308350
SLC25A22	ClinVar, OMIM, HUMSAVAR	HGNC link	11p15.5	1	PS308350
KCNB1	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.13	1	PS308350
ALG13	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq23	2	PS212065, PS308350
ARX	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp21.3	5	PS607432, PS309510, 300004, PS308350, PS309530
AARS	ClinVar, OMIM, HUMSAVAR	HGNC link	16q22.1	2	PS118220, PS308350
KCNT1	ClinVar, OMIM, HUMSAVAR	HGNC link	9q34.3	3	PS600513, PS607596, PS308350
HCN1	ClinVar, OMIM, HUMSAVAR	HGNC link	5p12	1	PS308350
ITPA	ClinVar, OMIM	HGNC link	20p13	2	613850, PS308350
WWOX	ClinVar, OMIM, HUMSAVAR	HGNC link	16q23.1	3	133239, 614322, PS308350
PCDH19	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq22.1	1	PS308350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 138	3	SCN9A, SCN2A, SCN1A

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
20q13.33	2	KCNQ2, EEF1A2
2q24.3	3	SCN9A, SCN2A, SCN1A
9q34.11	3	STXBP1, DNM1, SPTAN1

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
9q34	4	STXBP1, DNM1, KCNT1, SPTAN1
2q24	3	SCN9A, SCN2A, SCN1A
Xp22	2	CDKL5, PIGA
20q13	4	SLC12A5, KCNQ2, KCNB1, EEF1A2
12p13	2	NECAP1, GRIN2B
1p34	2	ST3GAL3, SZT2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
2q2	3	SCN9A, SCN2A, SCN1A
Xq2	2	ALG13, PCDH19
16q2	2	AARS, WWOX
12p1	2	NECAP1, GRIN2B
20p1	2	PLCB1, ITPA
1p3	3	ST3GAL3, DOCK7, SZT2
Xp2	3	CDKL5, ARX, PIGA
20q1	4	SLC12A5, KCNQ2, KCNB1, EEF1A2
9q3	4	STXBP1, DNM1, KCNT1, SPTAN1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
20q	4	SLC12A5, KCNQ2, KCNB1, EEF1A2
1p	4	SZT2, DOCK7, KCNA2, ST3GAL3
2q	3	SCN9A, SCN2A, SCN1A
12p	2	NECAP1, GRIN2B
20p	2	PLCB1, ITPA
9q	4	STXBP1, DNM1, KCNT1, SPTAN1
Xp	4	CDKL5, SLC35A2, PIGA, ARX
Xq	3	ARHGEF9, PCDH19, ALG13
16q	3	AARS, WWOX, GNAO1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	3	NECAP1, SCN8A, GRIN2B
20	6	PLCB1, KCNQ2, ITPA, EEF1A2, SLC12A5, KCNB1
16	4	AARS, TBC1D24, WWOX, GNAO1
1	4	SZT2, DOCK7, KCNA2, ST3GAL3
2	3	SCN9A, SCN2A, SCN1A
5	2	HCN1, GABRA1
9	4	STXBP1, DNM1, KCNT1, SPTAN1
X	7	CDKL5, PIGA, ARHGEF9, PCDH19, SLC35A2, ALG13, ARX

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
ARX	YES	1	KDM5C	0
REST	NO	29	SCG3, KCNN4, TPH2, NRP1, AVP, GLRA1, TUBB3, CACNA1H, OPRM1, CARTPT, SYN1, CHGA, GABRB3, CD59, GRIN2B, KCNQ3, TAC3, VGF, VIP, BDNF, LIN28A, CHGB, GJD2, PCSK1, PENK, TAC1, GRIN1, DYRK1A, KCNQ2	2	GRIN2B, KCNQ2

regulated gene	associated to this disease	# TFs	TFs
SCN9A	YES	1	USF1
GRIN2B	YES	2	HDAC1, REST
ST3GAL3	YES	1	MYC
KCNQ2	YES	2	SP1, REST
WWOX	YES	1	E2F1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NECAP1	STXBP1	No	1	APP
NECAP1	SZT2	No	1	REL
NECAP1	PNKP	No	1	APP
NECAP1	ARX	No	2	CLTC, GTSE1
PIGA	SIK1	No	1	ELAVL1
PIGA	WWOX	No	2	ELAVL1, FAM189A2
GNAO1	EEF1A2	No	2	DGUOK, NUFIP1
GNAO1	DOCK7	No	1	NTRK1
GNAO1	STXBP1	No	7	HTT, HAX1, DNAAF2, DGUOK, NUFIP1, NTRK1, ARMC1
GNAO1	DNM1	No	5	NTRK1, DNAAF2, DGUOK, NUFIP1, HAX1
GNAO1	GRIN2B	No	1	CAMK2A
GNAO1	SLC12A5	No	2	DGUOK, NUFIP1
GNAO1	SPTAN1	No	3	NTRK1, MED4, TMOD3
GNAO1	PNKP	No	1	NTRK1
GNAO1	SLC25A22	No	1	NTRK1
GNAO1	AARS	No	1	NTRK1
EEF1A2	DOCK7	No	2	LGR4, VCP
EEF1A2	STXBP1	No	3	DGUOK, NUFIP1, GJA1
EEF1A2	DNM1	No	3	ARRB1, DGUOK, NUFIP1
EEF1A2	GRIN2B	No	1	PARK2
EEF1A2	SIK1	No	1	STK11
EEF1A2	CDKL5	No	1	MGMT
EEF1A2	SLC12A5	No	2	DGUOK, NUFIP1
EEF1A2	SPTAN1	No	15	CEP76, CEP57, NEDD8, VCP, ARRB2, RPA1, RPA2, COPS5, MAPK6, PTEN, ERG, ARRB1, RPA3, CUL1, CUL3
EEF1A2	TBC1D24	No	1	CUL3
EEF1A2	ST3GAL3	No	1	ACTG1
EEF1A2	PLCB1	No	1	CEP76
EEF1A2	PNKP	No	4	RPA3, RPA1, MCM5, RPA2
EEF1A2	SLC25A22	No	2	CUL3, CUL4A
EEF1A2	AARS	No	1	ISG15
EEF1A2	WWOX	No	5	PABPC1, PKLR, RPL30, PABPC3, POLR2A
DOCK7	STXBP1	No	2	NTRK1, ARPC3
DOCK7	DNM1	No	1	NTRK1
DOCK7	SIK1	No	2	YWHAZ, XPO1
DOCK7	SPTAN1	No	12	STAU1, MYO1C, CDK2, VCP, ACTB, MLH1, CAPZA2, SIRT7, MYO19, MYH9, NTRK1, PAN2
DOCK7	PLCB1	No	1	PTGER3
DOCK7	PNKP	No	1	NTRK1
DOCK7	SLC25A22	No	1	NTRK1
DOCK7	AARS	No	5	NTRK1, NXF1, MOV10, CDK2, SIRT7
DOCK7	ITPA	No	2	NXF1, MOV10
DOCK7	WWOX	Yes	2	TP53, YWHAZ
STXBP1	DNM1	No	7	HAX1, DNAAF2, DGUOK, NUFIP1, NTRK1, IQCB1, CDK5
STXBP1	GRIN2B	No	1	PRKCA
STXBP1	CDKL5	No	1	DLG4
STXBP1	SLC12A5	No	2	DGUOK, NUFIP1
STXBP1	SCN2A	No	1	DLG4
STXBP1	SPTAN1	No	2	NTRK1, SHC1
STXBP1	PNKP	No	2	NTRK1, APP
STXBP1	SLC25A22	No	1	NTRK1
STXBP1	KCNB1	No	2	SNAP25, STX1A
STXBP1	AARS	No	1	NTRK1
STXBP1	ITPA	No	1	SHMT1
DNM1	KCNA2	No	1	PTK2B
DNM1	SLC12A5	No	2	DGUOK, NUFIP1
DNM1	SPTAN1	No	3	NTRK1, ARRB1, PIN4
DNM1	PNKP	No	1	NTRK1
DNM1	SLC25A22	No	1	NTRK1
DNM1	KCNB1	No	1	SRC
DNM1	ARX	No	1	CLINT1
DNM1	AARS	No	1	NTRK1
KCNA2	GRIN2B	No	2	FYN, DLG4
GRIN2B	SPTAN1	Yes	2	CAPN1, GRIN1
SIK1	WWOX	No	2	ELAVL1, YWHAZ
ARHGEF9	SPTAN1	No	3	PLEKHA5, SMURF1, GPHN
CDKL5	SCN2A	No	1	DLG4
CDKL5	ITPA	No	1	SERPINB8
CDKL5	WWOX	No	1	UBAP2
SZT2	ITPA	No	1	SHMT2
SPTAN1	TBC1D24	No	1	CUL3
SPTAN1	PLCB1	No	3	GAN, CEP76, SPTBN1
SPTAN1	PNKP	No	4	NTRK1, RPA3, RPA2, RPA1
SPTAN1	SCN1A	No	1	GAN
SPTAN1	SLC25A22	No	2	NTRK1, CUL3
SPTAN1	ALG13	No	1	SAV1
SPTAN1	AARS	No	9	EIF4A3, ACTA2, CALML3, CDK2, SIRT7, HSP90AA1, HSP90AB1, NTRK1, STAT1
SPTAN1	ITPA	No	1	TES
SPTAN1	WWOX	No	8	EIF4A3, HNRNPK, CDC5L, MYH7, HNRNPR, DHX9, CANX, SF3B3
TBC1D24	SLC25A22	No	2	KCTD5, CUL3
PLCB1	SCN1A	No	1	GAN
PNKP	SLC25A22	No	2	NTRK1, NF2
PNKP	AARS	No	2	NTRK1, SBDS
PNKP	WWOX	No	2	HNRNPU, NOLC1
SLC25A22	AARS	No	1	NTRK1
KCNB1	HCN1	No	1	NEDD4L
ALG13	WWOX	No	1	ATN1
ARX	WWOX	No	1	CYFIP1
AARS	ITPA	No	3	NXF1, MOV10, ENO1
AARS	WWOX	No	2	EIF4A3, ENO1
ITPA	WWOX	No	4	HNRNPA3, HSPB1, ENO1, SERPINB5

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
GRIN2B	TBC1D24	No	1	TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
NECAP1	DNM1	No	-	2	EPS15, AP2A1
GNAO1	EEF1A2	No	-	1	UBC
GNAO1	DOCK7	No	-	3	UBC, RAC1, CDC42
GNAO1	STXBP1	No	-	1	UBC
GNAO1	DNM1	No	-	9	NOS3, CXCR3, F2R, MAPK1, CXCL12, RGS19, UBC, SRC, EDN1
GNAO1	GRIN2B	No	-	8	PRKX, HRAS, PRKACG, GRM1, SRC, PRKACA, CXCL12, PRKACB
GNAO1	SIK1	No	-	1	UBC
GNAO1	CDKL5	No	-	1	RAC1
GNAO1	SPTAN1	No	-	6	RAC1, UBC, RHOA, PXN, SRC, HRAS
GNAO1	PLCB1	Yes	activation, binding	29	EDNRB, GNGT2, GNG2, GNA11, GNG13, PLCB4, GNAQ, GNAI1, PRKCG, PLCB2, GNAT1, MAPK14, GNAT2, GNB1, GNA15, GNGT1, GNB2, PLCB3, EDN1, GNA14, IGF1R, PRKCB, GNB4, GNAI3, GNAT3, GRM1, PRKCA, CXCL12, GNAZ
GNAO1	KCNB1	No	-	6	PRKX, PRKACG, CCR5, SRC, PRKACA, PRKACB
GNAO1	AARS	No	-	1	UBC
GNAO1	ITPA	No	-	1	UBC
GNAO1	WWOX	No	-	6	MAPK8, GLI1, DVL2, UBC, AKT1, SRC
EEF1A2	DOCK7	No	-	1	UBC
EEF1A2	STXBP1	No	-	1	UBC
EEF1A2	DNM1	No	-	2	UBC, ACTA2
EEF1A2	SIK1	No	-	2	UBC, FOS
EEF1A2	SPTAN1	No	-	3	UBC, ACTA1, ACTA2
EEF1A2	AARS	No	-	1	UBC
EEF1A2	ITPA	No	-	1	UBC
EEF1A2	WWOX	No	-	1	UBC
DOCK7	STXBP1	No	-	1	UBC
DOCK7	DNM1	No	-	1	UBC
DOCK7	SIK1	No	-	1	UBC
DOCK7	CDKL5	No	-	1	RAC1
DOCK7	SPTAN1	No	-	2	UBC, RAC1
DOCK7	PLCB1	No	-	1	MET
DOCK7	AARS	No	-	1	UBC
DOCK7	ITPA	No	-	1	UBC
DOCK7	WWOX	No	-	2	UBC, ERBB2
SCN9A	SCN2A	No	-	2	SCN2B, SCN1B
SCN9A	SCN8A	No	-	2	SCN2B, SCN1B
STXBP1	DNM1	No	-	3	UBC, CDK5, DYRK1A
STXBP1	GRIN2B	No	-	1	CDK5
STXBP1	SIK1	No	-	1	UBC
STXBP1	GABRA1	No	-	1	NSF
STXBP1	SPTAN1	No	-	2	UBC, STX3
STXBP1	KCNB1	No	-	3	INS, CDK5, VAMP2
STXBP1	AARS	No	-	1	UBC
STXBP1	ITPA	No	-	1	UBC
STXBP1	WWOX	No	-	1	UBC
DNM1	KCNA2	No	-	1	CTTN
DNM1	GRIN2B	No	-	6	CXCL12, GIPC1, GNB2L1, SRC, CDK5, NOS1
DNM1	SIK1	No	-	1	UBC
DNM1	GABRA1	Yes	activation, binding	4	GABRA5, GABRA2, GABRA3, GABRA6
DNM1	SPTAN1	No	-	3	SRC, UBC, ACTA2
DNM1	PLCB1	No	-	6	CCL11, F2, AGT, EGFR, CXCL12, EDN1
DNM1	KCNB1	No	-	2	SRC, CDK5
DNM1	AARS	No	-	1	UBC
DNM1	ITPA	No	-	1	UBC
DNM1	WWOX	No	-	3	SRC, UBC, MAP2K1
KCNA2	GRIN2B	No	-	4	PTK2B, VEGFA, DLG1, DLG4
KCNA2	SCN2A	No	-	1	SCN8A
KCNA2	SPTAN1	No	-	3	PTPRA, KCNQ3, KCNQ2
KCNA2	KCNQ2	Yes	binding	38	KCNB2, KCNA7, KCNQ5, KCNC3, KCNH3, KCNC4, KCNAB1, KCND2, KCNG1, KCNH1, KCNS2, KCNA5, KCNA1, KCNA4, KCNG2, KCNH4, KCNS1, KCNAB2, KCNF1, KCNC1, KCNA10, KCNA3, KCNC2, KCNH8, KCNH5, KCNS3, KCNV2, KCNH6, KCNQ4, KCNB1, KCNAB3, KCNV1, KCNQ3, KCNG4, KCNG3, KCND3, KCNA6, KCNH7
KCNA2	SCN8A	Yes	binding	0
KCNA2	KCNB1	Yes	binding	38	KCNB2, KCNA7, KCNQ5, KCNC3, KCNH3, KCNC4, KCNAB1, KCND2, KCNG1, KCNH1, KCNS2, KCNA5, KCNA1, KCNA4, KCNG2, KCNH4, KCNS1, KCNAB2, KCNF1, KCNC1, KCNA10, KCNA3, KCNC2, KCNH8, KCNH5, KCNS3, KCNV2, KCNH6, KCNQ4, KCNAB3, KCNV1, KCNQ3, KCNG4, KCNG3, KCND3, KCNQ2, KCNA6, KCNH7
GRIN2B	SIK1	No	-	2	CREB1, BDNF
GRIN2B	GABRA1	No	-	1	CREB1
GRIN2B	SLC12A5	No	-	1	BDNF
GRIN2B	SPTAN1	No	-	5	SRC, ACTN2, HRAS, FYN, GRIN1
GRIN2B	PLCB1	No	-	2	CXCL12, GRM1
GRIN2B	KCNB1	No	-	7	PRKX, CDK5, PRKACG, SRC, FYN, PRKACA, PRKACB
GRIN2B	WWOX	No	-	2	SRC, CREB1
SIK1	GABRA1	No	-	1	CREB1
SIK1	SLC12A5	No	-	1	BDNF
SIK1	SPTAN1	No	-	1	UBC
SIK1	AARS	No	-	1	UBC
SIK1	ITPA	No	-	1	UBC
SIK1	WWOX	No	-	3	UBC, CREB1, TP53
CDKL5	SPTAN1	No	-	1	RAC1
GABRA1	SLC12A5	No	-	1	CLCN2
GABRA1	WWOX	No	-	1	CREB1
SCN2A	KCNQ2	No	-	1	ANK3
SCN2A	SCN8A	Yes	binding	7	SCN2B, SCN10A, SCN3B, SCNN1A, SCN1B, SCNN1G, SCNN1B
SPTAN1	KCNQ2	Yes	binding	10	SPTBN1, SPTA1, NFASC, ANK1, NRCAM, SPTB, SPTBN2, SPTBN4, SPTBN5, KCNQ3
SPTAN1	KCNB1	No	-	4	SRC, FYN, KCNQ3, KCNQ2
SPTAN1	AARS	No	-	1	UBC
SPTAN1	ITPA	No	-	1	UBC
SPTAN1	WWOX	No	-	3	SRC, UBC, EZR
KCNQ2	SCN8A	No	-	1	KCNA2
KCNQ2	KCNB1	Yes	binding	38	KCNB2, KCNA7, KCNQ5, KCNC3, KCNH3, KCNC4, KCNAB1, KCND2, KCNG1, KCNH1, KCNS2, KCNA5, KCNA1, KCNA4, KCNG2, KCNH4, KCNS1, KCNAB2, KCNF1, KCNC1, KCNA10, KCNA3, KCNC2, KCNH8, KCNH5, KCNS3, KCNV2, KCNH6, KCNQ4, KCNAB3, KCNV1, KCNA2, KCNQ3, KCNG4, KCNG3, KCND3, KCNA6, KCNH7
SCN8A	KCNB1	No	-	1	KCNA2
KCNB1	WWOX	No	-	1	SRC
AARS	ITPA	No	-	1	UBC
AARS	WWOX	No	-	1	UBC
ITPA	WWOX	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
DNM1	SPTAN1	No	-	1	ACTB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SPTAN1	AARS	No	1	ACTA2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
SCN2A	KCNQ2	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	5	ALG13, ITPA, PLCB1, PIGA, ST3GAL3
Dopaminergic synapse	hsa04728	5.69	4	GNAO1, PLCB1, GRIN2B, SCN1A
Rap1 signaling pathway	hsa04015	4.97	3	GNAO1, GRIN2B, PLCB1
Retrograde endocannabinoid signaling	hsa04723	6.03	3	GNAO1, GABRA1, PLCB1
Cholinergic synapse	hsa04725	5.88	3	GNAO1, PLCB1, KCNQ2
Glutamatergic synapse	hsa04724	5.84	3	GNAO1, GRIN2B, PLCB1
GABAergic synapse	hsa04727	6.24	3	GNAO1, SLC12A5, GABRA1
Circadian entrainment	hsa04713	6.11	3	GNAO1, GRIN2B, PLCB1
Chagas disease (American trypanosomiasis)	hsa05142	5.99	2	GNAO1, PLCB1
Endocrine and other factor-regulated calcium reabsorption	hsa04961	7.12	2	PLCB1, DNM1
Nicotine addiction	hsa05033	7.38	2	GRIN2B, GABRA1
Neuroactive ligand-receptor interaction	hsa04080	4.58	2	GRIN2B, GABRA1
Estrogen signaling pathway	hsa04915	6.11	2	GNAO1, PLCB1
Synaptic vesicle cycle	hsa04721	6.74	2	DNM1, STXBP1
Long-term potentiation	hsa04720	6.64	2	GRIN2B, PLCB1
Morphine addiction	hsa05032	6.15	2	GNAO1, GABRA1
Melanogenesis	hsa04916	5.97	2	GNAO1, PLCB1
Long-term depression	hsa04730	6.74	2	GNAO1, PLCB1
Alcoholism	hsa05034	5.59	2	GNAO1, GRIN2B
Serotonergic synapse	hsa04726	5.84	2	GNAO1, PLCB1
Huntington's disease	hsa05016	5.17	2	GRIN2B, PLCB1
Alzheimer's disease	hsa05010	5.34	2	GRIN2B, PLCB1
Oxytocin signaling pathway	hsa04921	5.4	2	GNAO1, PLCB1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Nervous system	NEW	3.77	0.0	KCNA2, ARHGEF9, SPTAN1, GNAO1, GABRA1, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, GRIN2B, PLCB1, EEF1A2, KCNQ2
Retrograde endocannabinoid signaling (hsa04723)	-	6.03	0.046	GNAO1, ARHGEF9, GRIN2B, PLCB1, GABRA1
Dopaminergic synapse (hsa04728)	-	5.69	0.026	SPTAN1, GNAO1, SCN1A, DNM1, GRIN2B, PLCB1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Neuronal System	R-HSA-112316	4.82	9	ARHGEF9, HCN1, GABRA1, STXBP1, KCNA2, KCNB1, GRIN2B, PLCB1, KCNQ2
Axon guidance	R-HSA-422475	3.93	8	SPTAN1, SCN1A, SCN9A, DNM1, SCN2A, SCN8A, GRIN2B, KCNQ2
Signal Transduction	R-HSA-162582	1.78	8	WWOX, ARHGEF9, SPTAN1, GNAO1, DNM1, ST3GAL3, GRIN2B, PLCB1
Developmental Biology	R-HSA-1266738	3.48	8	SPTAN1, SCN1A, SCN9A, DNM1, SCN2A, SCN8A, GRIN2B, KCNQ2
L1CAM interactions	R-HSA-373760	6.19	7	SPTAN1, SCN1A, SCN9A, DNM1, SCN2A, SCN8A, KCNQ2
Interaction between L1 and Ankyrins	R-HSA-445095	8.03	6	SPTAN1, SCN9A, SCN1A, SCN2A, SCN8A, KCNQ2
Transmission across Chemical Synapses	R-HSA-112315	5.28	5	ARHGEF9, GRIN2B, PLCB1, GABRA1, STXBP1
Metabolism	R-HSA-1430728	2.34	5	KCNB1, ITPA, PLCB1, ST3GAL3, STXBP1
Signaling by GPCR	R-HSA-372790	2.68	5	GNAO1, ARHGEF9, GRIN2B, PLCB1, SPTAN1
Transmembrane transport of small molecules	R-HSA-382551	3.79	5	SLC13A5, SLC12A5, ARHGEF9, GABRA1, SLC35A2
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	R-HSA-112314	5.85	4	ARHGEF9, GRIN2B, PLCB1, GABRA1
Signalling by NGF	R-HSA-166520	4.23	4	GRIN2B, ARHGEF9, DNM1, SPTAN1
Metabolism of proteins	R-HSA-392499	3.41	4	PIGA, ALG13, EEF1A2, ST3GAL3
Potassium Channels	R-HSA-1296071	6.35	4	KCNB1, KCNQ2, KCNA2, HCN1
Voltage gated Potassium channels	R-HSA-1296072	7.56	3	KCNQ2, KCNB1, KCNA2
Regulation of insulin secretion	R-HSA-422356	6.66	3	PLCB1, KCNB1, STXBP1
Immune System	R-HSA-168256	2.37	3	GRIN2B, DNM1, SPTAN1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	GRIN2B, PLCB1, SPTAN1
Innate Immune System	R-HSA-168249	3.17	3	GRIN2B, DNM1, SPTAN1
Integration of energy metabolism	R-HSA-163685	6.24	3	PLCB1, KCNB1, STXBP1
Signaling by ERBB4	R-HSA-1236394	4.7	3	GRIN2B, WWOX, SPTAN1
SLC-mediated transmembrane transport	R-HSA-425407	4.95	3	SLC13A5, SLC12A5, SLC35A2
Post-translational protein modification	R-HSA-597592	4.54	3	PIGA, ALG13, ST3GAL3
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	GRIN2B, DNM1, SPTAN1
Ion channel transport	R-HSA-983712	5.34	2	GABRA1, ARHGEF9
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	2	GRIN2B, SPTAN1
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	GRIN2B, SPTAN1
Signaling by Interleukins	R-HSA-449147	4.71	2	GRIN2B, SPTAN1
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	GRIN2B, SPTAN1
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	2	GRIN2B, SPTAN1
Interleukin-2 signaling	R-HSA-451927	5.05	2	GRIN2B, SPTAN1
Frs2-mediated activation	R-HSA-170968	5.12	2	GRIN2B, SPTAN1
Ligand-gated ion channel transport	R-HSA-975298	8.28	2	GABRA1, ARHGEF9
IGF1R signaling cascade	R-HSA-2428924	4.85	2	GRIN2B, SPTAN1
Downstream signal transduction	R-HSA-186763	4.65	2	GRIN2B, SPTAN1
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	2	GRIN2B, SPTAN1
DAP12 interactions	R-HSA-2172127	4.56	2	GRIN2B, SPTAN1
Signaling by Insulin receptor	R-HSA-74752	4.73	2	GRIN2B, SPTAN1
Insulin receptor signalling cascade	R-HSA-74751	4.85	2	GRIN2B, SPTAN1
EPH-Ephrin signaling	R-HSA-2682334	6.43	2	GRIN2B, DNM1
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	2	GRIN2B, SPTAN1
MAPK family signaling cascades	R-HSA-5683057	4.89	2	GRIN2B, SPTAN1
Ca2+ pathway	R-HSA-4086398	7.1	2	GNAO1, PLCB1
Signaling by VEGF	R-HSA-194138	4.66	2	GRIN2B, SPTAN1
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	GRIN2B, SPTAN1
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	GRIN2B, SPTAN1
GABA A receptor activation	R-HSA-977441	9.28	2	GABRA1, ARHGEF9
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	GRIN2B, SPTAN1
IRS-mediated signalling	R-HSA-112399	4.87	2	GRIN2B, SPTAN1
GABA receptor activation	R-HSA-977443	7.2	2	GABRA1, ARHGEF9
Asparagine N-linked glycosylation	R-HSA-446203	6.1	2	ALG13, ST3GAL3
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	GRIN2B, SPTAN1
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	GRIN2B, SPTAN1
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	GRIN2B, SPTAN1
GPCR downstream signaling	R-HSA-388396	3.07	2	ARHGEF9, PLCB1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	2	GRIN2B, SPTAN1
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	GRIN2B, SPTAN1
Signalling to ERKs	R-HSA-187687	5.04	2	GRIN2B, SPTAN1
Signaling by FGFR4	R-HSA-5654743	4.69	2	GRIN2B, SPTAN1
Signaling by FGFR3	R-HSA-5654741	4.69	2	GRIN2B, SPTAN1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	GRIN2B, SPTAN1
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	GRIN2B, SPTAN1
Signaling by FGFR	R-HSA-190236	4.67	2	GRIN2B, SPTAN1
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	2	GRIN2B, SPTAN1
Signaling by Leptin	R-HSA-2586552	5.1	2	GRIN2B, SPTAN1
beta-catenin independent WNT signaling	R-HSA-3858494	5.83	2	GNAO1, PLCB1
Interleukin receptor SHC signaling	R-HSA-912526	5.09	2	GRIN2B, SPTAN1
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	GRIN2B, SPTAN1
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	GRIN2B, SPTAN1
Membrane Trafficking	R-HSA-199991	5.26	2	NECAP1, DNM1
Signaling by PDGF	R-HSA-186797	4.53	2	GRIN2B, SPTAN1
Signalling to RAS	R-HSA-167044	5.08	2	GRIN2B, SPTAN1
DAP12 signaling	R-HSA-2424491	4.64	2	GRIN2B, SPTAN1
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	GRIN2B, SPTAN1
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	R-HSA-446193	6.92	2	ALG13, ST3GAL3
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	2	GRIN2B, SPTAN1
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	GRIN2B, SPTAN1
Signaling by EGFR	R-HSA-177929	4.59	2	GRIN2B, SPTAN1
Vesicle-mediated transport	R-HSA-5653656	4.33	2	NECAP1, DNM1
Prolonged ERK activation events	R-HSA-169893	5.11	2	GRIN2B, SPTAN1
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	GRIN2B, SPTAN1
Signaling by Wnt	R-HSA-195721	4.79	2	GNAO1, PLCB1
PLC beta mediated events	R-HSA-112043	7.52	2	GNAO1, PLCB1
G-protein mediated events	R-HSA-112040	7.49	2	GNAO1, PLCB1
Signaling by FGFR2	R-HSA-5654738	4.68	2	GRIN2B, SPTAN1
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	GRIN2B, SPTAN1
Signaling by FGFR1	R-HSA-5654736	4.69	2	GRIN2B, SPTAN1
Opioid Signalling	R-HSA-111885	6.64	2	GNAO1, PLCB1
ARMS-mediated activation	R-HSA-170984	5.12	2	GRIN2B, SPTAN1
SOS-mediated signalling	R-HSA-112412	5.15	2	GRIN2B, SPTAN1
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	2	GRIN2B, SPTAN1
Signaling by ERBB2	R-HSA-1227986	4.66	2	GRIN2B, SPTAN1
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	GRIN2B, SPTAN1
Gene Expression	R-HSA-74160	2.72	2	EEF1A2, AARS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Regulation of insulin secretion (R-HSA-422356)	-	6.66	0.002	ARHGEF9, STXBP1, KCNB1, GRIN2B, PLCB1, KCNA2
Interaction between L1 and Ankyrins (R-HSA-445095)	-	8.03	0.0	SPTAN1, SCN9A, SCN1A, SCN2A, SCN8A, KCNQ2
Integration of energy metabolism (R-HSA-163685)	-	6.24	0.013	ARHGEF9, STXBP1, KCNB1, GRIN2B, PLCB1, KCNA2
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (R-HSA-381676)	NEW	7.59	0.011	GRIN2B, ARHGEF9, KCNA2, KCNB1
Neuronal System (R-HSA-112316)	-	4.82	0.0	ARHGEF9, HCN1, SPTAN1, GABRA1, STXBP1, KCNA2, KCNB1, GRIN2B, PLCB1, KCNQ2
L1CAM interactions (R-HSA-373760)	-	6.19	0.0	SPTAN1, SCN1A, SCN9A, DNM1, SCN2A, GRIN2B, SCN8A, KCNQ2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	31	WWOX, AARS, NECAP1, SCN9A, SLC35A2, DOCK7, ARX, HCN1, GNAO1, EEF1A2, SIK1, GRIN2B, TBC1D24, ITPA, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, PCDH19, PLCB1, KCNA2, CDKL5, SZT2, ALG13, PIGA, SPTAN1, SCN8A, GABRA1, KCNQ2
protein binding (GO:0005515)	0.46	23	WWOX, NECAP1, PIGA, DOCK7, SPTAN1, GNAO1, EEF1A2, KCNA2, GRIN2B, TBC1D24, HCN1, STXBP1, SLC12A5, DNM1, KCNB1, PLCB1, SIK1, CDKL5, SZT2, ALG13, SLC35A2, PNKP, KCNQ2
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	15	SCN2A, HCN1, SLC13A5, SCN9A, KCNT1, SCN1A, SLC12A5, KCNB1, SLC35A2, KCNQ2, SLC25A22, GABRA1, SCN8A, GRIN2B, KCNA2
ion transmembrane transporter activity (GO:0015075)	3.04	15	SCN2A, HCN1, SLC13A5, SCN1A, GABRA1, GRIN2B, SCN9A, SLC35A2, KCNB1, SLC12A5, KCNA2, SLC25A22, SCN8A, KCNT1, KCNQ2
transmembrane transporter activity (GO:0022857)	2.82	15	KCNT1, SCN2A, HCN1, SLC13A5, SCN1A, GABRA1, SCN9A, SLC35A2, KCNB1, SLC12A5, KCNA2, SLC25A22, SCN8A, GRIN2B, KCNQ2
substrate-specific transporter activity (GO:0022892)	2.72	15	SCN8A, HCN1, SLC13A5, SCN1A, GABRA1, SCN9A, SLC35A2, KCNB1, SLC12A5, KCNA2, SLC25A22, GRIN2B, KCNT1, KCNQ2, SCN2A
transporter activity (GO:0005215)	2.57	15	SCN2A, HCN1, SLC13A5, SCN9A, KCNT1, SCN1A, SLC12A5, KCNB1, SLC35A2, KCNA2, SLC25A22, GABRA1, SCN8A, GRIN2B, KCNQ2
catalytic activity (GO:0003824)	1.05	13	CDKL5, WWOX, AARS, PNKP, GNAO1, EEF1A2, ALG13, ITPA, DNM1, PIGA, ST3GAL3, PLCB1, SIK1
heterocyclic compound binding (GO:1901363)	1.06	13	CDKL5, PNKP, HCN1, GNAO1, EEF1A2, ALG13, ITPA, STXBP1, DNM1, ARX, AARS, SCN8A, SIK1
organic cyclic compound binding (GO:0097159)	1.05	13	HCN1, CDKL5, ARX, PNKP, GNAO1, EEF1A2, ALG13, ITPA, STXBP1, DNM1, AARS, SCN8A, SIK1
cation transmembrane transporter activity (GO:0008324)	3.32	12	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	11	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
ion channel activity (GO:0005216)	3.71	11	KCNT1, KCNB1, HCN1, SCN1A, GABRA1, SCN9A, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	11	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
channel activity (GO:0015267)	3.6	11	KCNT1, KCNB1, HCN1, SCN1A, GABRA1, SCN9A, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
gated channel activity (GO:0022836)	3.96	11	KCNT1, KCNB1, HCN1, SCN1A, GABRA1, SCN9A, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
passive transmembrane transporter activity (GO:0022803)	3.6	11	KCNT1, KCNB1, HCN1, SCN1A, GABRA1, SCN9A, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
metal ion transmembrane transporter activity (GO:0046873)	3.71	11	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
substrate-specific channel activity (GO:0022838)	3.67	11	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, GABRA1, SCN8A, GRIN2B, KCNQ2
cation binding (GO:0043169)	1.4	10	ITPA, SPTAN1, GNAO1, SCN9A, SCN1A, AARS, GRIN2B, PLCB1, PCDH19, SIK1
nucleotide binding (GO:0000166)	1.96	10	CDKL5, PNKP, HCN1, GNAO1, EEF1A2, ITPA, DNM1, AARS, SCN8A, SIK1
ion binding (GO:0043167)	1.36	10	ITPA, SPTAN1, GNAO1, SCN1A, SCN9A, AARS, GRIN2B, PLCB1, PCDH19, SIK1
small molecule binding (GO:0036094)	1.89	10	CDKL5, HCN1, PNKP, GNAO1, EEF1A2, ITPA, DNM1, AARS, SCN8A, SIK1
metal ion binding (GO:0046872)	1.41	10	ITPA, SPTAN1, GNAO1, SCN1A, SCN9A, AARS, GRIN2B, PLCB1, PCDH19, SIK1
nucleoside phosphate binding (GO:1901265)	1.96	10	CDKL5, PNKP, HCN1, GNAO1, EEF1A2, ITPA, DNM1, AARS, SCN8A, SIK1
cation channel activity (GO:0005261)	4.04	9	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, SCN8A, KCNQ2
carbohydrate derivative binding (GO:0097367)	2.03	9	CDKL5, PNKP, HCN1, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
enzyme binding (GO:0019899)	2.27	9	CDKL5, EEF1A2, WWOX, STXBP1, SLC12A5, DOCK7, DNM1, PLCB1, SIK1
voltage-gated channel activity (GO:0022832)	4.49	9	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, SCN8A, KCNQ2
purine ribonucleotide binding (GO:0032555)	2.2	9	CDKL5, PNKP, HCN1, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
purine nucleotide binding (GO:0017076)	2.19	9	CDKL5, HCN1, PNKP, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
voltage-gated ion channel activity (GO:0005244)	4.49	9	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, SCN8A, KCNQ2
ribonucleotide binding (GO:0032553)	2.19	9	CDKL5, PNKP, HCN1, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
hydrolase activity (GO:0016787)	1.9	8	ITPA, PNKP, GNAO1, EEF1A2, ALG13, DNM1, AARS, PLCB1
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	8	CDKL5, PNKP, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
ribonucleoside binding (GO:0032549)	2.22	8	CDKL5, PNKP, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
purine ribonucleoside binding (GO:0032550)	2.22	8	CDKL5, PNKP, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
purine nucleoside binding (GO:0001883)	2.22	8	CDKL5, PNKP, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
nucleoside binding (GO:0001882)	2.21	8	CDKL5, PNKP, GNAO1, EEF1A2, DNM1, AARS, SCN8A, SIK1
nucleic acid binding (GO:0003676)	1.44	7	ARX, PNKP, EEF1A2, ALG13, STXBP1, DNM1, AARS
sodium ion transmembrane transporter activity (GO:0015081)	4.83	6	HCN1, SLC13A5, SCN9A, SCN1A, SCN2A, SCN8A
adenyl nucleotide binding (GO:0030554)	2.4	6	CDKL5, PNKP, HCN1, AARS, SCN8A, SIK1
transferase activity (GO:0016740)	1.95	6	CDKL5, PNKP, ALG13, PIGA, ST3GAL3, SIK1
adenyl ribonucleotide binding (GO:0032559)	2.41	6	CDKL5, PNKP, HCN1, AARS, SCN8A, SIK1
molecular function regulator (GO:0098772)	2.51	6	ARHGEF9, SPTAN1, PLCB1, DOCK7, GRIN2B, TBC1D24
potassium ion transmembrane transporter activity (GO:0015079)	4.77	6	HCN1, KCNT1, SLC12A5, KCNQ2, KCNB1, KCNA2
potassium channel activity (GO:0005267)	4.94	5	KCNQ2, KCNT1, HCN1, KCNB1, KCNA2
sodium channel activity (GO:0005272)	6.13	5	SCN1A, SCN8A, SCN9A, SCN2A, HCN1
protein kinase binding (GO:0019901)	3.44	5	SLC12A5, SIK1, EEF1A2, STXBP1, DNM1
kinase binding (GO:0019900)	3.32	5	SLC12A5, EEF1A2, DNM1, SIK1, STXBP1
RNA binding (GO:0003723)	2.36	5	EEF1A2, ALG13, AARS, STXBP1, DNM1
voltage-gated potassium channel activity (GO:0005249)	5.24	5	KCNB1, KCNQ2, KCNT1, KCNA2, HCN1
voltage-gated sodium channel activity (GO:0005248)	6.74	5	SCN9A, SCN8A, SCN1A, SCN2A, HCN1
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030)	6.74	5	SCN1A, SCN8A, SCN9A, SCN2A, HCN1
ATP binding (GO:0005524)	2.43	5	PNKP, CDKL5, SIK1, SCN8A, AARS
voltage-gated cation channel activity (GO:0022843)	4.83	5	KCNA2, KCNT1, HCN1, KCNB1, KCNQ2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	4	GNAO1, ITPA, EEF1A2, DNM1
secondary active transmembrane transporter activity (GO:0015291)	4.29	4	SLC13A5, SLC12A5, SLC35A2, SLC25A22
symporter activity (GO:0015293)	4.78	4	SLC13A5, SLC12A5, SLC35A2, SLC25A22
anion transmembrane transporter activity (GO:0008509)	4.43	4	SLC13A5, SLC12A5, GABRA1, SLC25A22
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	4	ARHGEF9, GRIN2B, DOCK7, SPTAN1
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	4	GNAO1, EEF1A2, ITPA, DNM1
pyrophosphatase activity (GO:0016462)	3.04	4	GNAO1, ITPA, EEF1A2, DNM1
macromolecular complex binding (GO:0044877)	2.61	4	GNAO1, SPTAN1, DNM1, ARX
identical protein binding (GO:0042802)	2.63	4	PLCB1, DNM1, STXBP1, HCN1
signal transducer activity (GO:0004871)	2.28	4	GNAO1, GRIN2B, PLCB1, GABRA1
protein dimerization activity (GO:0046983)	2.72	4	WWOX, PLCB1, DNM1, KCNB1
active transmembrane transporter activity (GO:0022804)	3.85	4	SLC13A5, SLC12A5, SLC35A2, SLC25A22
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	3	GRIN2B, ARHGEF9, SPTAN1
guanyl ribonucleotide binding (GO:0032561)	3.73	3	GNAO1, EEF1A2, DNM1
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	CDKL5, PNKP, SIK1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	CDKL5, PNKP, SIK1
solute:cation symporter activity (GO:0015294)	5.15	3	SLC13A5, SLC12A5, SLC35A2
kinase activity (GO:0016301)	2.93	3	CDKL5, PNKP, SIK1
GTPase activity (GO:0003924)	4.31	3	GNAO1, EEF1A2, DNM1
ligand-gated ion channel activity (GO:0015276)	4.8	3	GRIN2B, GABRA1, HCN1
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	PLCB1, PNKP, AARS
nucleoside-triphosphatase activity (GO:0017111)	3.09	3	GNAO1, EEF1A2, DNM1
molecular transducer activity (GO:0060089)	2.32	3	GRIN2B, GABRA1, HCN1
calcium ion binding (GO:0005509)	3.17	3	PCDH19, PLCB1, SPTAN1
transferase activity, transferring glycosyl groups (GO:0016757)	4.08	3	PIGA, ALG13, ST3GAL3
ligand-gated channel activity (GO:0022834)	4.8	3	GRIN2B, GABRA1, HCN1
protein complex binding (GO:0032403)	3.09	3	GNAO1, DNM1, SPTAN1
delayed rectifier potassium channel activity (GO:0005251)	6.15	3	KCNA2, KCNB1, KCNQ2
receptor activity (GO:0004872)	2.32	3	GRIN2B, GABRA1, HCN1
guanyl nucleotide binding (GO:0019001)	3.73	3	GNAO1, EEF1A2, DNM1
poly(A) RNA binding (GO:0044822)	2.69	3	ALG13, DNM1, STXBP1
transmembrane receptor activity (GO:0099600)	2.53	3	GRIN2B, GABRA1, HCN1
GTP binding (GO:0005525)	3.78	3	GNAO1, EEF1A2, DNM1
organic acid transmembrane transporter activity (GO:0005342)	4.97	2	SLC13A5, SLC25A22
alkali metal ion binding (GO:0031420)	6.69	2	SCN1A, SCN9A
Rho GTPase binding (GO:0017048)	5.36	2	CDKL5, DOCK7
phosphoric ester hydrolase activity (GO:0042578)	3.82	2	PLCB1, PNKP
small GTPase binding (GO:0031267)	4.13	2	CDKL5, DOCK7
GTPase binding (GO:0051020)	4.05	2	CDKL5, DOCK7
zinc ion binding (GO:0008270)	2.66	2	GRIN2B, AARS
DNA binding (GO:0003677)	1.92	2	PNKP, ARX
acetylglucosaminyltransferase activity (GO:0008375)	5.85	2	PIGA, ALG13
amino acid binding (GO:0016597)	5.71	2	GRIN2B, AARS
signaling receptor activity (GO:0038023)	2.49	2	GRIN2B, GABRA1
anion binding (GO:0043168)	4.17	2	GRIN2B, AARS
transition metal ion binding (GO:0046914)	2.48	2	GRIN2B, AARS
nucleoside-triphosphatase regulator activity (GO:0060589)	3.92	2	TBC1D24, PLCB1
SNARE binding (GO:0000149)	4.87	2	SPTAN1, STXBP1
Rac GTPase binding (GO:0048365)	6.05	2	CDKL5, DOCK7
structural molecule activity (GO:0005198)	3.1	2	SPTAN1, SLC25A22
protein serine/threonine kinase activity (GO:0004674)	3.64	2	CDKL5, SIK1
G-protein coupled receptor binding (GO:0001664)	4.18	2	GNAO1, DNM1
inorganic anion transmembrane transporter activity (GO:0015103)	4.87	2	SLC12A5, GABRA1
protein kinase activity (GO:0004672)	3.27	2	CDKL5, SIK1
double-stranded DNA binding (GO:0003690)	3.09	2	PNKP, ARX
enzyme regulator activity (GO:0030234)	2.85	2	TBC1D24, PLCB1
chloride transmembrane transporter activity (GO:0015108)	5.24	2	SLC12A5, GABRA1
anion:cation symporter activity (GO:0015296)	6.15	2	SLC13A5, SLC12A5
extracellular ligand-gated ion channel activity (GO:0005230)	5.42	2	GRIN2B, GABRA1
GTPase activator activity (GO:0005096)	4.11	2	TBC1D24, PLCB1
Ras GTPase binding (GO:0017016)	4.2	2	CDKL5, DOCK7
GTPase regulator activity (GO:0030695)	4.01	2	TBC1D24, PLCB1
syntaxin binding (GO:0019905)	5.19	2	SPTAN1, STXBP1
UDP-glycosyltransferase activity (GO:0008194)	4.81	2	PIGA, ALG13
carboxylic acid transmembrane transporter activity (GO:0046943)	4.99	2	SLC13A5, SLC25A22
protein N-terminus binding (GO:0047485)	5.11	2	SPTAN1, STXBP1
cytoskeletal protein binding (GO:0008092)	3.02	2	KCNQ2, SPTAN1
sodium ion binding (GO:0031402)	7.1	2	SCN9A, SCN1A
carboxylic acid binding (GO:0031406)	4.64	2	GRIN2B, AARS
organic anion transmembrane transporter activity (GO:0008514)	5.31	2	SLC13A5, SLC25A22
transmembrane signaling receptor activity (GO:0004888)	2.57	2	GRIN2B, GABRA1
calmodulin binding (GO:0005516)	4.55	2	PLCB1, SPTAN1
active ion transmembrane transporter activity (GO:0022853)	5.06	2	SLC13A5, SLC12A5
transferase activity, transferring hexosyl groups (GO:0016758)	4.43	2	PIGA, ALG13
receptor binding (GO:0005102)	2.43	2	GNAO1, DNM1
enzyme activator activity (GO:0008047)	3.56	2	TBC1D24, PLCB1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
potassium channel activity (GO:0005267)	-	4.94	0.001	KCNQ2, KCNT1, HCN1, KCNB1, KCNA2
cation channel activity (GO:0005261)	-	4.04	0.0	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, SCN8A, GRIN2B, KCNQ2
sodium ion transmembrane transporter activity (GO:0015081)	-	4.83	0.005	HCN1, SLC13A5, SCN9A, SCN1A, SCN2A, SCN8A
anion transmembrane transporter activity (GO:0008509)	-	4.43	0.042	SLC13A5, SLC12A5, GABRA1, SLC25A22, SLC35A2
transmembrane transporter activity (GO:0022857)	-	2.82	0.0	ARHGEF9, SPTAN1, HCN1, SLC13A5, SCN1A, GABRA1, GRIN2B, SCN9A, SLC35A2, STXBP1, KCNB1, SLC12A5, KCNA2, SLC25A22, SCN8A, KCNT1, KCNQ2, SCN2A
voltage-gated cation channel activity (GO:0022843)	-	4.83	0.0	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, SCN8A, GRIN2B, KCNQ2
passive transmembrane transporter activity (GO:0022803)	-	3.6	0.0	KCNT1, ARHGEF9, SPTAN1, HCN1, SCN9A, GABRA1, SCN1A, STXBP1, KCNB1, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
metal ion transmembrane transporter activity (GO:0046873)	-	3.71	0.0	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
sodium channel activity (GO:0005272)	-	6.13	0.0	SCN1A, SCN8A, SCN9A, SCN2A, HCN1
symporter activity (GO:0015293)	-	4.78	0.043	SLC13A5, SLC12A5, SLC35A2, SLC25A22
transporter activity (GO:0005215)	-	2.57	0.0	ARHGEF9, SPTAN1, HCN1, SLC13A5, SCN9A, GABRA1, GRIN2B, SCN1A, SLC35A2, STXBP1, KCNB1, GNAO1, SLC12A5, KCNA2, SLC25A22, SCN8A, EEF1A2, KCNT1, KCNQ2, SCN2A
ion channel activity (GO:0005216)	-	3.71	0.0	ARHGEF9, SPTAN1, HCN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNB1, KCNQ2, SCN2A, GABRA1, GRIN2B, SCN8A, KCNA2
cation transmembrane transporter activity (GO:0008324)	-	3.32	0.0	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, STXBP1, SLC12A5, KCNA2, SCN2A, SCN8A, GRIN2B, KCNQ2
delayed rectifier potassium channel activity (GO:0005251)	-	6.15	0.011	KCNA2, KCNB1, KCNQ2
substrate-specific transmembrane transporter activity (GO:0022891)	-	2.9	0.0	ARHGEF9, SPTAN1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, STXBP1, KCNB1, SLC12A5, KCNQ2, SLC25A22, GABRA1, SCN8A, GRIN2B, KCNA2, SCN2A
inorganic cation transmembrane transporter activity (GO:0022890)	-	3.49	0.0	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, SCN8A, GRIN2B, KCNQ2
substrate-specific transporter activity (GO:0022892)	-	2.72	0.0	ARHGEF9, SPTAN1, HCN1, SLC13A5, SCN9A, GABRA1, GRIN2B, SCN1A, SLC35A2, STXBP1, KCNB1, GNAO1, SLC12A5, KCNA2, SLC25A22, SCN8A, KCNT1, KCNQ2, SCN2A
voltage-gated ion channel activity (GO:0005244)	-	4.49	0.0	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, SCN8A, GRIN2B, KCNQ2
ion transmembrane transporter activity (GO:0015075)	-	3.04	0.0	ARHGEF9, SCN2A, HCN1, SLC13A5, SCN9A, KCNT1, SCN1A, SLC35A2, STXBP1, KCNB1, SPTAN1, KCNQ2, SLC25A22, SLC12A5, GABRA1, GRIN2B, SCN8A, KCNA2
voltage-gated channel activity (GO:0022832)	-	4.49	0.0	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	-	3.87	0.0	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, SCN8A, KCNQ2
channel activity (GO:0015267)	-	3.6	0.0	KCNT1, ARHGEF9, SPTAN1, HCN1, SCN9A, GABRA1, SCN1A, STXBP1, KCNB1, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
gated channel activity (GO:0022836)	-	3.96	0.0	ARHGEF9, HCN1, SPTAN1, SCN1A, GABRA1, GRIN2B, SCN9A, STXBP1, KCNB1, KCNA2, SCN2A, SCN8A, KCNT1, KCNQ2
voltage-gated potassium channel activity (GO:0005249)	-	5.24	0.0	KCNQ2, KCNA2, KCNT1, KCNB1, HCN1
voltage-gated sodium channel activity (GO:0005248)	-	6.74	0.0	SCN9A, SCN8A, SCN1A, SCN2A, HCN1
substrate-specific channel activity (GO:0022838)	-	3.67	0.0	ARHGEF9, HCN1, SPTAN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNB1, KCNA2, SCN2A, GABRA1, SCN8A, GRIN2B, KCNQ2
potassium ion transmembrane transporter activity (GO:0015079)	-	4.77	0.002	KCNQ2, KCNA2, KCNT1, KCNB1, HCN1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism process (GO:0044699)	0.48	33	WWOX, ARX, SPTAN1, KCNT1, SCN9A, PIGA, DOCK7, AARS, HCN1, GNAO1, SIK1, ST3GAL3, GRIN2B, TBC1D24, ITPA, SCN2A, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, PCDH19, PLCB1, KCNA2, CDKL5, SZT2, ALG13, SLC35A2, SLC13A5, SCN8A, GABRA1, KCNQ2
cellular process (GO:0009987)	0.26	31	WWOX, ARX, SPTAN1, KCNT1, PIGA, DOCK7, AARS, HCN1, GNAO1, EEF1A2, SIK1, ST3GAL3, GRIN2B, TBC1D24, ITPA, SCN2A, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, SLC25A22, PLCB1, KCNA2, CDKL5, SZT2, ALG13, SCN8A, GABRA1, KCNQ2
biological regulation (GO:0065007)	0.39	28	WWOX, AARS, SPTAN1, SCN9A, PIGA, DOCK7, ARX, HCN1, GNAO1, EEF1A2, SIK1, SCN2A, GRIN2B, TBC1D24, ARHGEF9, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, PLCB1, KCNA2, CDKL5, SZT2, SCN8A, GABRA1, KCNQ2
single-organism cellular process (GO:0044763)	0.65	28	WWOX, AARS, SPTAN1, KCNT1, PIGA, DOCK7, ARX, HCN1, GNAO1, SIK1, ST3GAL3, GRIN2B, TBC1D24, ITPA, SCN2A, PNKP, STXBP1, SLC12A5, DNM1, KCNB1, PLCB1, KCNA2, CDKL5, GABRA1, ALG13, SCN8A, SZT2, KCNQ2
regulation of biological process (GO:0050789)	0.45	27	WWOX, AARS, SPTAN1, SCN9A, PIGA, DOCK7, ARX, HCN1, GNAO1, EEF1A2, KCNA2, SCN2A, GRIN2B, TBC1D24, ARHGEF9, PNKP, SCN1A, STXBP1, DNM1, KCNB1, PLCB1, SIK1, CDKL5, SZT2, SCN8A, GABRA1, KCNQ2
regulation of cellular process (GO:0050794)	0.5	22	WWOX, AARS, SPTAN1, DOCK7, ARX, GNAO1, EEF1A2, KCNA2, SCN2A, GRIN2B, TBC1D24, ARHGEF9, PNKP, SCN1A, STXBP1, DNM1, KCNB1, PLCB1, SIK1, CDKL5, SZT2, GABRA1
localization (GO:0051179)	1.4	21	KCNA2, ARHGEF9, HCN1, NECAP1, SLC13A5, SCN1A, GABRA1, GRIN2B, SCN9A, SLC35A2, STXBP1, KCNB1, SLC12A5, DOCK7, DNM1, SLC25A22, SPTAN1, SCN8A, KCNT1, KCNQ2, SCN2A
establishment of localization (GO:0051234)	1.48	20	ARHGEF9, HCN1, NECAP1, SLC13A5, SCN9A, KCNT1, SCN1A, SLC35A2, STXBP1, KCNB1, SPTAN1, DNM1, KCNA2, SLC25A22, SLC12A5, GABRA1, SCN8A, GRIN2B, KCNQ2, SCN2A
transport (GO:0006810)	1.51	20	ARHGEF9, NECAP1, HCN1, SLC13A5, SCN9A, KCNT1, SCN1A, SLC35A2, DNM1, KCNB1, SLC12A5, SPTAN1, KCNQ2, SLC25A22, GABRA1, GRIN2B, STXBP1, SCN8A, KCNA2, SCN2A
organic substance metabolic process (GO:0071704)	0.63	17	CDKL5, WWOX, SPTAN1, PNKP, EEF1A2, ST3GAL3, ALG13, ITPA, DNM1, PIGA, ARX, AARS, SLC25A22, SLC35A2, GRIN2B, PLCB1, SIK1
ion transport (GO:0006811)	2.66	17	ARHGEF9, SCN2A, HCN1, SLC13A5, SCN1A, GABRA1, GRIN2B, SCN9A, SLC35A2, STXBP1, KCNB1, SLC12A5, KCNA2, SLC25A22, SCN8A, KCNT1, KCNQ2
metabolic process (GO:0008152)	0.58	17	CDKL5, WWOX, ST3GAL3, SPTAN1, EEF1A2, ALG13, ITPA, AARS, PNKP, PIGA, DNM1, ARX, SLC25A22, SLC35A2, GRIN2B, PLCB1, SIK1
developmental process (GO:0032502)	1.36	16	KCNA2, WWOX, AARS, HCN1, GNAO1, SZT2, STXBP1, SLC12A5, DOCK7, KCNQ2, ARX, SCN8A, PLCB1, PCDH19, SIK1, SCN2A
primary metabolic process (GO:0044238)	0.69	16	CDKL5, WWOX, ST3GAL3, SPTAN1, EEF1A2, ALG13, ITPA, AARS, PNKP, PIGA, ARX, SLC25A22, SLC35A2, GRIN2B, PLCB1, SIK1
transmembrane transport (GO:0055085)	2.72	16	ARHGEF9, SCN8A, HCN1, SLC13A5, SCN1A, GABRA1, SCN9A, SLC35A2, KCNB1, SLC12A5, KCNA2, SLC25A22, GRIN2B, KCNT1, KCNQ2, SCN2A
ion transmembrane transport (GO:0034220)	3.08	15	ARHGEF9, SCN8A, HCN1, SLC13A5, SCN1A, GABRA1, SCN9A, KCNB1, SLC12A5, KCNA2, SLC25A22, GRIN2B, KCNT1, KCNQ2, SCN2A
cellular metabolic process (GO:0044237)	0.69	15	CDKL5, SPTAN1, PNKP, EEF1A2, ST3GAL3, ALG13, ITPA, AARS, PIGA, DNM1, ARX, SLC25A22, GRIN2B, PLCB1, SIK1
regulation of localization (GO:0032879)	1.94	14	KCNA2, KCNQ2, HCN1, GNAO1, SCN1A, SCN9A, STXBP1, KCNB1, DOCK7, DNM1, SCN2A, SCN8A, PLCB1, SIK1
multicellular organismal process (GO:0032501)	1.45	13	AARS, GNAO1, SCN1A, SZT2, SCN9A, DNM1, SLC12A5, DOCK7, KCNA2, ARX, GRIN2B, PLCB1, SIK1
response to stimulus (GO:0050896)	1.22	13	WWOX, PNKP, HCN1, GNAO1, EEF1A2, SCN9A, KCNB1, SLC12A5, AARS, GRIN2B, GABRA1, SIK1, SCN2A
anatomical structure development (GO:0048856)	1.58	13	ARX, HCN1, GNAO1, SZT2, SLC12A5, DOCK7, KCNQ2, AARS, PCDH19, PLCB1, SCN8A, SIK1, SCN2A
macromolecule metabolic process (GO:0043170)	0.83	13	CDKL5, SPTAN1, PNKP, EEF1A2, ST3GAL3, ALG13, AARS, PIGA, DNM1, ARX, SLC25A22, GRIN2B, SIK1
single-organism developmental process (GO:0044767)	1.49	13	WWOX, ARX, HCN1, GNAO1, SZT2, STXBP1, SLC12A5, DOCK7, KCNA2, AARS, PCDH19, PLCB1, SIK1
positive regulation of biological process (GO:0048518)	1.2	13	CDKL5, ARHGEF9, KCNB1, PNKP, EEF1A2, WWOX, STXBP1, PIGA, DOCK7, DNM1, ARX, PLCB1, SIK1
single-organism metabolic process (GO:0044710)	1.63	12	ITPA, WWOX, PNKP, SPTAN1, ST3GAL3, ALG13, SLC35A2, DNM1, PIGA, AARS, GRIN2B, PLCB1
cellular macromolecule metabolic process (GO:0044260)	0.93	12	CDKL5, SLC25A22, PNKP, EEF1A2, AARS, PIGA, SPTAN1, ARX, ST3GAL3, DNM1, GRIN2B, SIK1
cation transport (GO:0006812)	3.11	12	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
signal transduction (GO:0007165)	1.28	12	WWOX, SCN2A, SPTAN1, GNAO1, GABRA1, DNM1, KCNB1, DOCK7, AARS, GRIN2B, PLCB1, SIK1
regulation of transport (GO:0051049)	2.24	12	KCNA2, KCNB1, HCN1, GNAO1, SCN1A, SCN9A, STXBP1, DNM1, SIK1, SCN2A, SCN8A, KCNQ2
regulation of molecular function (GO:0065009)	1.78	12	CDKL5, ARHGEF9, SPTAN1, PNKP, GNAO1, TBC1D24, SZT2, DOCK7, GRIN2B, PLCB1, EEF1A2, SIK1
regulation of biological quality (GO:0065008)	1.68	12	KCNB1, SPTAN1, HCN1, SCN1A, SCN9A, STXBP1, PNKP, SLC12A5, AARS, SCN8A, KCNA2, SCN2A
monovalent inorganic cation transport (GO:0015672)	3.74	12	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
response to chemical (GO:0042221)	1.98	11	WWOX, KCNB1, HCN1, GNAO1, EEF1A2, SCN9A, SLC12A5, AARS, GRIN2B, GABRA1, SIK1
regulation of catalytic activity (GO:0050790)	1.97	11	CDKL5, ARHGEF9, SPTAN1, PNKP, GNAO1, TBC1D24, EEF1A2, DOCK7, GRIN2B, PLCB1, SZT2
metal ion transport (GO:0030001)	3.36	11	KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
single-multicellular organism process (GO:0044707)	1.78	11	AARS, SCN1A, SZT2, SCN9A, DNM1, SLC12A5, DOCK7, ARX, GRIN2B, PLCB1, SIK1
inorganic ion transmembrane transport (GO:0098660)	3.38	11	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, SLC12A5, KCNA2, SCN2A, SCN8A, GABRA1, KCNQ2
positive regulation of catalytic activity (GO:0043085)	2.4	10	CDKL5, ARHGEF9, PNKP, SPTAN1, GNAO1, TBC1D24, EEF1A2, DOCK7, GRIN2B, PLCB1
regulation of metabolic process (GO:0019222)	1.02	10	WWOX, AARS, PNKP, SZT2, PIGA, DOCK7, ARX, PLCB1, EEF1A2, SIK1
protein metabolic process (GO:0019538)	1.45	10	CDKL5, AARS, SPTAN1, EEF1A2, ALG13, PIGA, ST3GAL3, SLC25A22, GRIN2B, SIK1
regulation of ion transport (GO:0043269)	3.4	10	KCNA2, KCNB1, HCN1, GNAO1, SCN1A, SCN9A, SIK1, SCN2A, SCN8A, KCNQ2
cellular component organization (GO:0016043)	1.24	10	ITPA, SPTAN1, GNAO1, SZT2, STXBP1, DOCK7, DNM1, KCNB1, TBC1D24, KCNA2
single-organism transport (GO:0044765)	2.18	10	STXBP1, HCN1, SLC13A5, KCNT1, SLC35A2, DNM1, SLC12A5, KCNA2, KCNB1, KCNQ2
inorganic cation transmembrane transport (GO:0098662)	3.55	10	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
positive regulation of molecular function (GO:0044093)	2.23	10	CDKL5, ARHGEF9, PNKP, SPTAN1, GNAO1, PLCB1, EEF1A2, DOCK7, GRIN2B, TBC1D24
single-organism localization (GO:1902578)	2.09	10	STXBP1, HCN1, SLC13A5, KCNT1, SLC35A2, DNM1, SLC12A5, KCNA2, KCNB1, KCNQ2
cation transmembrane transport (GO:0098655)	3.43	10	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, SLC12A5, KCNA2, SCN2A, SCN8A, KCNQ2
cellular component organization or biogenesis (GO:0071840)	1.22	10	ITPA, SPTAN1, GNAO1, SZT2, STXBP1, DOCK7, DNM1, KCNB1, TBC1D24, KCNA2
positive regulation of cellular process (GO:0048522)	1.3	10	CDKL5, ARHGEF9, PNKP, EEF1A2, WWOX, STXBP1, DOCK7, KCNB1, PLCB1, SIK1
cellular protein metabolic process (GO:0044267)	1.63	9	CDKL5, AARS, SPTAN1, EEF1A2, PIGA, ST3GAL3, SLC25A22, GRIN2B, SIK1
system process (GO:0003008)	2.3	9	GNAO1, SCN1A, SCN9A, DNM1, SLC12A5, AARS, GRIN2B, PLCB1, KCNA2
regulation of cellular metabolic process (GO:0031323)	1.07	9	WWOX, ARX, PNKP, EEF1A2, DOCK7, AARS, PLCB1, SZT2, SIK1
negative regulation of biological process (GO:0048519)	1.33	9	WWOX, ARX, SPTAN1, GNAO1, STXBP1, KCNB1, AARS, PLCB1, SIK1
regulation of hydrolase activity (GO:0051336)	2.53	8	CDKL5, ARHGEF9, SPTAN1, GNAO1, TBC1D24, DOCK7, GRIN2B, PLCB1
organic substance biosynthetic process (GO:1901576)	1.34	8	AARS, PNKP, EEF1A2, ST3GAL3, ALG13, PIGA, ARX, SLC25A22
cellular response to stimulus (GO:0051716)	1.97	8	WWOX, PNKP, HCN1, GABRA1, KCNB1, AARS, SIK1, SCN2A
positive regulation of GTPase activity (GO:0043547)	3.28	8	CDKL5, ARHGEF9, SPTAN1, GNAO1, TBC1D24, DOCK7, GRIN2B, PLCB1
positive regulation of hydrolase activity (GO:0051345)	2.91	8	CDKL5, ARHGEF9, SPTAN1, GNAO1, TBC1D24, DOCK7, GRIN2B, PLCB1
neurological system process (GO:0050877)	2.64	8	SCN1A, SCN9A, DNM1, SLC12A5, AARS, GRIN2B, PLCB1, KCNA2
biosynthetic process (GO:0009058)	1.32	8	AARS, PNKP, EEF1A2, ST3GAL3, ALG13, PIGA, ARX, SLC25A22
phosphate-containing compound metabolic process (GO:0006796)	2.16	8	CDKL5, PNKP, SPTAN1, ITPA, PIGA, GRIN2B, PLCB1, SIK1
regulation of transmembrane transport (GO:0034762)	3.74	8	KCNB1, HCN1, SCN9A, SCN1A, KCNA2, SCN2A, SCN8A, KCNQ2
phosphorus metabolic process (GO:0006793)	2.15	8	CDKL5, PNKP, SPTAN1, ITPA, PIGA, GRIN2B, PLCB1, SIK1
regulation of ion transmembrane transport (GO:0034765)	3.77	8	KCNB1, HCN1, SCN9A, SCN1A, KCNA2, SCN2A, SCN8A, KCNQ2
regulation of GTPase activity (GO:0043087)	3.21	8	CDKL5, ARHGEF9, SPTAN1, GNAO1, PLCB1, DOCK7, GRIN2B, TBC1D24
response to organic substance (GO:0010033)	2.2	8	WWOX, KCNB1, HCN1, GNAO1, GABRA1, AARS, GRIN2B, SIK1
negative regulation of cellular process (GO:0048523)	1.41	8	WWOX, ARX, SPTAN1, STXBP1, KCNB1, AARS, PLCB1, SIK1
regulation of primary metabolic process (GO:0080090)	1.08	8	WWOX, ARX, PNKP, EEF1A2, DOCK7, AARS, PLCB1, SIK1
regulation of membrane potential (GO:0042391)	3.89	7	SCN2A, HCN1, SCN9A, SCN1A, KCNB1, SCN8A, KCNA2
positive regulation of metabolic process (GO:0009893)	1.74	7	WWOX, PNKP, EEF1A2, PIGA, DOCK7, ARX, PLCB1
regulation of macromolecule metabolic process (GO:0060255)	1.08	7	WWOX, ARX, PNKP, DOCK7, AARS, PLCB1, SIK1
cellular developmental process (GO:0048869)	1.82	7	WWOX, HCN1, SZT2, DOCK7, ARX, PLCB1, SIK1
regulation of programmed cell death (GO:0043067)	2.49	7	WWOX, ARHGEF9, KCNB1, EEF1A2, STXBP1, AARS, SIK1
behavior (GO:0007610)	3.47	7	GNAO1, SCN9A, SCN1A, DNM1, SLC12A5, GRIN2B, PLCB1
regulation of cellular component organization (GO:0051128)	2.01	7	CDKL5, PNKP, SPTAN1, PLCB1, STXBP1, KCNB1, TBC1D24
cellular biosynthetic process (GO:0044249)	1.37	7	AARS, PNKP, EEF1A2, ST3GAL3, PIGA, ARX, SLC25A22
macromolecule modification (GO:0043412)	1.73	7	CDKL5, ST3GAL3, SPTAN1, PIGA, AARS, GRIN2B, SIK1
nitrogen compound metabolic process (GO:0006807)	1.13	7	ITPA, ARX, PNKP, EEF1A2, ST3GAL3, AARS, SLC25A22
cellular nitrogen compound metabolic process (GO:0034641)	1.22	7	ITPA, ARX, PNKP, EEF1A2, ST3GAL3, AARS, SLC25A22
cell communication (GO:0007154)	3.04	7	GABRA1, DNM1, SLC12A5, STXBP1, KCNB1, GRIN2B, KCNQ2
intracellular signal transduction (GO:0035556)	2.39	7	WWOX, SPTAN1, DOCK7, SCN2A, GRIN2B, PLCB1, SIK1
regulation of cell death (GO:0010941)	2.43	7	WWOX, ARHGEF9, KCNB1, EEF1A2, STXBP1, AARS, SIK1
regulation of apoptotic process (GO:0042981)	2.5	7	WWOX, ARHGEF9, KCNB1, EEF1A2, STXBP1, AARS, SIK1
cell surface receptor signaling pathway (GO:0007166)	2.09	6	WWOX, GNAO1, DNM1, KCNB1, GRIN2B, PLCB1
regulation of cellular biosynthetic process (GO:0031326)	1.38	6	WWOX, ARX, PNKP, AARS, PLCB1, SIK1
signaling (GO:0023052)	3.25	6	GABRA1, DNM1, SLC12A5, STXBP1, GRIN2B, KCNQ2
cellular response to chemical stimulus (GO:0070887)	2.57	6	WWOX, AARS, HCN1, GABRA1, KCNB1, SIK1
action potential (GO:0001508)	5.42	6	SCN2A, SCN9A, SCN1A, KCNB1, SCN8A, KCNA2
response to endogenous stimulus (GO:0009719)	2.79	6	WWOX, HCN1, GNAO1, GABRA1, AARS, SIK1
cellular potassium ion transport (GO:0071804)	4.79	6	HCN1, KCNT1, SLC12A5, KCNQ2, KCNB1, KCNA2
potassium ion transmembrane transport (GO:0071805)	4.79	6	HCN1, KCNT1, SLC12A5, KCNQ2, KCNB1, KCNA2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	6	WWOX, ARX, PNKP, AARS, PLCB1, SIK1
potassium ion transport (GO:0006813)	4.68	6	HCN1, KCNT1, SLC12A5, KCNQ2, KCNB1, KCNA2
cellular response to organic substance (GO:0071310)	2.78	6	WWOX, AARS, HCN1, GABRA1, KCNB1, SIK1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	6	WWOX, ARX, PNKP, AARS, PLCB1, SIK1
protein modification process (GO:0036211)	1.79	6	CDKL5, SPTAN1, PIGA, ST3GAL3, GRIN2B, SIK1
organic substance transport (GO:0071702)	2.15	6	SLC25A22, NECAP1, SLC13A5, STXBP1, SLC35A2, KCNB1
regulation of developmental process (GO:0050793)	2.1	6	CDKL5, PLCB1, DOCK7, ARX, TBC1D24, SIK1
regulation of biosynthetic process (GO:0009889)	1.37	6	WWOX, ARX, PNKP, AARS, PLCB1, SIK1
cellular protein modification process (GO:0006464)	1.79	6	CDKL5, SPTAN1, PIGA, ST3GAL3, GRIN2B, SIK1
sodium ion transport (GO:0006814)	4.75	6	HCN1, SLC13A5, SCN9A, SCN1A, SCN2A, SCN8A
macromolecule biosynthetic process (GO:0009059)	1.61	6	ARX, PNKP, EEF1A2, ST3GAL3, AARS, SLC25A22
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	6	WWOX, ARX, PNKP, AARS, PLCB1, SIK1
regulation of multicellular organismal process (GO:0051239)	1.87	6	CDKL5, GNAO1, DOCK7, ARX, PLCB1, KCNA2
chemical synaptic transmission (GO:0007268)	3.98	6	GABRA1, DNM1, SLC12A5, STXBP1, GRIN2B, KCNQ2
cell-cell signaling (GO:0007267)	3.35	6	GABRA1, DNM1, SLC12A5, STXBP1, GRIN2B, KCNQ2
single organism signaling (GO:0044700)	3.25	6	GABRA1, DNM1, SLC12A5, STXBP1, GRIN2B, KCNQ2
single-organism behavior (GO:0044708)	3.79	6	SCN9A, SCN1A, DNM1, SLC12A5, GRIN2B, PLCB1
anterograde trans-synaptic signaling (GO:0098916)	3.98	6	GABRA1, STXBP1, SLC12A5, DNM1, GRIN2B, KCNQ2
system development (GO:0048731)	2.92	6	SCN2A, SZT2, DOCK7, ARX, SCN8A, KCNQ2
synaptic signaling (GO:0099536)	3.98	6	GABRA1, STXBP1, SLC12A5, DNM1, GRIN2B, KCNQ2
trans-synaptic signaling (GO:0099537)	3.98	6	GABRA1, DNM1, SLC12A5, STXBP1, GRIN2B, KCNQ2
regulation of organelle organization (GO:0033043)	2.72	5	TBC1D24, SPTAN1, PLCB1, PNKP, STXBP1
phosphorylation (GO:0016310)	2.63	5	SPTAN1, GRIN2B, SIK1, CDKL5, PNKP
regulation of postsynaptic membrane potential (GO:0060078)	5.72	5	SCN9A, SCN8A, SCN1A, SCN2A, HCN1
cell differentiation (GO:0030154)	2.14	5	DOCK7, WWOX, PLCB1, SIK1, ARX
regulation of response to stimulus (GO:0048583)	1.54	5	SCN1A, ARHGEF9, WWOX, PLCB1, SZT2
anion transport (GO:0006820)	3.71	5	SLC13A5, SLC12A5, GABRA1, STXBP1, SLC25A22
small molecule metabolic process (GO:0044281)	2.38	5	PNKP, ITPA, PLCB1, SLC35A2, AARS
cellular macromolecule biosynthetic process (GO:0034645)	1.66	5	PNKP, AARS, EEF1A2, ARX, SLC25A22
regulation of signaling (GO:0023051)	1.72	5	ARHGEF9, WWOX, PLCB1, KCNB1, STXBP1
regulation of cell communication (GO:0010646)	1.73	5	ARHGEF9, WWOX, PLCB1, KCNB1, STXBP1
organic cyclic compound metabolic process (GO:1901360)	1.26	5	PNKP, ITPA, WWOX, AARS, ARX
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	5	DOCK7, WWOX, PLCB1, PNKP, ARX
sodium ion transmembrane transport (GO:0035725)	5.23	5	SCN9A, SCN8A, SCN1A, SCN2A, HCN1
positive regulation of cellular metabolic process (GO:0031325)	1.81	5	DOCK7, EEF1A2, PLCB1, WWOX, PNKP
organelle organization (GO:0006996)	2.02	5	DOCK7, ITPA, DNM1, SPTAN1, STXBP1
lipid metabolic process (GO:0006629)	2.68	5	ALG13, PIGA, PLCB1, WWOX, ST3GAL3
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	5	PNKP, WWOX, PLCB1, SIK1, ARX
neuronal action potential (GO:0019228)	6.4	5	SCN9A, SCN8A, SCN1A, SCN2A, KCNA2
response to stress (GO:0006950)	1.8	5	GNAO1, SCN9A, SCN2A, AARS, PNKP
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	5	AARS, EEF1A2, ST3GAL3, ARX, SLC25A22
response to oxygen-containing compound (GO:1901700)	2.57	5	GNAO1, AARS, GRIN2B, KCNB1, HCN1
response to abiotic stimulus (GO:0009628)	2.8	5	PNKP, SLC12A5, EEF1A2, SIK1, SCN2A
organonitrogen compound metabolic process (GO:1901564)	2.32	5	AARS, EEF1A2, ITPA, ST3GAL3, SLC25A22
vesicle-mediated transport (GO:0016192)	2.72	5	KCNB1, NECAP1, SPTAN1, STXBP1, DNM1
nervous system development (GO:0007399)	3.53	5	KCNQ2, SCN8A, DOCK7, SCN2A, ARX
regulation of gene expression (GO:0010468)	1.37	5	SIK1, WWOX, PLCB1, AARS, ARX
cellular response to endogenous stimulus (GO:0071495)	3.33	4	GABRA1, WWOX, SIK1, HCN1
protein localization (GO:0008104)	2.36	4	KCNB1, NECAP1, STXBP1, HCN1
cell projection organization (GO:0030030)	3.14	4	GNAO1, DOCK7, SZT2, TBC1D24
membrane depolarization (GO:0051899)	5.62	4	SCN1A, SCN8A, SCN9A, SCN2A
positive regulation of cell death (GO:0010942)	3.32	4	EEF1A2, ARHGEF9, WWOX, SIK1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	4	PNKP, ITPA, AARS, ARX
heterocycle metabolic process (GO:0046483)	1.31	4	PNKP, ITPA, AARS, ARX
positive regulation of apoptotic process (GO:0043065)	3.38	4	EEF1A2, ARHGEF9, WWOX, SIK1
macromolecule localization (GO:0033036)	2.34	4	KCNB1, NECAP1, HCN1, STXBP1
positive regulation of programmed cell death (GO:0043068)	3.38	4	EEF1A2, ARHGEF9, WWOX, SIK1
positive regulation of cellular component organization (GO:0051130)	2.68	4	CDKL5, PLCB1, PNKP, KCNB1
protein phosphorylation (GO:0006468)	2.89	4	GRIN2B, SIK1, SPTAN1, CDKL5
cellular aromatic compound metabolic process (GO:0006725)	1.3	4	PNKP, ITPA, AARS, ARX
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	WWOX, PLCB1, SIK1, ARX
anion transmembrane transport (GO:0098656)	4.51	4	SLC13A5, SLC12A5, GABRA1, SLC25A22
regulation of cell differentiation (GO:0045595)	2.42	4	DOCK7, CDKL5, PLCB1, SIK1
response to organonitrogen compound (GO:0010243)	3.2	4	GNAO1, GABRA1, AARS, HCN1
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	WWOX, PLCB1, SIK1, ARX
cellular lipid metabolic process (GO:0044255)	2.92	4	ALG13, PIGA, PLCB1, ST3GAL3
membrane depolarization during action potential (GO:0086010)	6.07	4	SCN1A, SCN8A, SCN9A, SCN2A
cellular localization (GO:0051641)	2.32	4	KCNB1, DOCK7, SPTAN1, STXBP1
amide biosynthetic process (GO:0043604)	3.6	4	AARS, EEF1A2, SLC25A22, ST3GAL3
cellular amide metabolic process (GO:0043603)	3.23	4	AARS, EEF1A2, ST3GAL3, SLC25A22
organonitrogen compound biosynthetic process (GO:1901566)	2.85	4	AARS, EEF1A2, ST3GAL3, SLC25A22
response to nitrogen compound (GO:1901698)	3.12	4	GNAO1, GABRA1, AARS, HCN1
regulation of RNA metabolic process (GO:0051252)	1.52	4	WWOX, PLCB1, SIK1, ARX
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	WWOX, PLCB1, SIK1, ARX
organophosphate metabolic process (GO:0019637)	3.04	4	PIGA, PLCB1, ITPA, PNKP
carbohydrate derivative metabolic process (GO:1901135)	3.07	4	PIGA, ALG13, ITPA, ST3GAL3
positive regulation of developmental growth (GO:0048639)	4.67	3	CDKL5, PLCB1, ARX
regulation of developmental growth (GO:0048638)	4.04	3	CDKL5, PLCB1, ARX
negative regulation of metabolic process (GO:0009892)	1.93	3	PLCB1, SIK1, ARX
cellular component assembly (GO:0022607)	2.14	3	DNM1, KCNB1, KCNA2
regulation of phosphate metabolic process (GO:0019220)	2.35	3	DOCK7, EEF1A2, PLCB1
positive regulation of growth (GO:0045927)	4.25	3	CDKL5, PLCB1, ARX
regulation of secretion (GO:0051046)	3.2	3	KCNA2, KCNB1, STXBP1
positive regulation of biosynthetic process (GO:0009891)	2.29	3	WWOX, PLCB1, PNKP
macromolecular complex subunit organization (GO:0043933)	2.14	3	DNM1, KCNB1, KCNA2
peptide biosynthetic process (GO:0043043)	3.73	3	EEF1A2, AARS, SLC25A22
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	3	GRIN2B, PLCB1, DNM1
positive regulation of developmental process (GO:0051094)	2.77	3	CDKL5, PLCB1, ARX
learning or memory (GO:0007611)	4.33	3	GRIN2B, PLCB1, SLC12A5
nucleic acid metabolic process (GO:0090304)	1.46	3	PNKP, AARS, ARX
negative regulation of signaling (GO:0023057)	2.65	3	WWOX, KCNB1, STXBP1
regulation of neuron apoptotic process (GO:0043523)	4.47	3	AARS, KCNB1, STXBP1
regulation of secretion by cell (GO:1903530)	3.28	3	KCNA2, KCNB1, STXBP1
neuron projection development (GO:0031175)	4.58	3	GNAO1, TBC1D24, DOCK7
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	3	GRIN2B, PLCB1, DNM1
anatomical structure morphogenesis (GO:0009653)	2.53	3	SZT2, DOCK7, WWOX
multicellular organism development (GO:0007275)	2.54	3	DOCK7, SIK1, ARX
response to organic cyclic compound (GO:0014070)	3.07	3	GNAO1, GABRA1, HCN1
regulation of vesicle-mediated transport (GO:0060627)	3.63	3	DNM1, KCNB1, STXBP1
single-organism biosynthetic process (GO:0044711)	2.8	3	PIGA, ALG13, ST3GAL3
negative regulation of biosynthetic process (GO:0009890)	2.47	3	PLCB1, SIK1, ARX
establishment of localization in cell (GO:0051649)	2.47	3	KCNB1, SPTAN1, STXBP1
regulation of cell cycle (GO:0051726)	2.93	3	CDKL5, PLCB1, SIK1
regulation of signal transduction (GO:0009966)	1.84	3	ARHGEF9, WWOX, PLCB1
glutamate receptor signaling pathway (GO:0007215)	5.99	3	GRIN2B, PLCB1, KCNB1
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	3	DOCK7, EEF1A2, PLCB1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	3	WWOX, PLCB1, PNKP
regulation of protein metabolic process (GO:0051246)	1.93	3	DOCK7, PLCB1, AARS
single-organism organelle organization (GO:1902589)	2.68	3	DOCK7, SPTAN1, STXBP1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)	3.79	3	GNAO1, WWOX, PLCB1
macromolecular complex assembly (GO:0065003)	2.55	3	DNM1, KCNB1, KCNA2
protein oligomerization (GO:0051259)	3.71	3	DNM1, KCNB1, KCNA2
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	PLCB1, SIK1, ARX
animal organ development (GO:0048513)	2.53	3	PCDH19, PLCB1, AARS
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	3	GNAO1, GABRA1, PLCB1
locomotory behavior (GO:0007626)	4.53	3	GNAO1, SCN1A, DNM1
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	PLCB1, SIK1, ARX
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	3	WWOX, PLCB1, PNKP
positive regulation of phosphate metabolic process (GO:0045937)	2.78	3	DOCK7, EEF1A2, PLCB1
positive regulation of transport (GO:0051050)	2.9	3	DNM1, KCNB1, STXBP1
protein complex assembly (GO:0006461)	2.78	3	KCNA2, KCNB1, DNM1
sensory perception (GO:0007600)	2.93	3	SCN9A, KCNA2, DNM1
regulation of cellular localization (GO:0060341)	3.03	3	DNM1, KCNB1, STXBP1
organic anion transport (GO:0015711)	4.07	3	SLC13A5, SLC25A22, STXBP1
establishment of protein localization (GO:0045184)	2.53	3	NECAP1, KCNB1, STXBP1
dicarboxylic acid transport (GO:0006835)	5.62	3	SLC13A5, SLC25A22, STXBP1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	3	WWOX, PLCB1, PNKP
regulation of neuron death (GO:1901214)	4.19	3	AARS, KCNB1, STXBP1
movement of cell or subcellular component (GO:0006928)	2.61	3	CDKL5, SPTAN1, ARX
carboxylic acid transport (GO:0046942)	4.28	3	SLC13A5, STXBP1, SLC25A22
regulation of phosphorylation (GO:0042325)	2.5	3	DOCK7, EEF1A2, PLCB1
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	DOCK7, EEF1A2, PLCB1
positive regulation of phosphorylation (GO:0042327)	2.9	3	DOCK7, EEF1A2, PLCB1
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	DOCK7, PLCB1, AARS
protein complex subunit organization (GO:0071822)	2.6	3	KCNA2, KCNB1, DNM1
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	CDKL5, PLCB1, ARX
carbohydrate derivative biosynthetic process (GO:1901137)	3.73	3	PIGA, ALG13, ST3GAL3
regulation of response to stress (GO:0080134)	2.53	3	SCN1A, SZT2, PLCB1
Wnt signaling pathway (GO:0016055)	3.88	3	GNAO1, WWOX, PLCB1
cognition (GO:0050890)	4.2	3	SLC12A5, PLCB1, GRIN2B
regulation of growth (GO:0040008)	3.26	3	CDKL5, PLCB1, ARX
regulation of cellular component biogenesis (GO:0044087)	3.08	3	TBC1D24, SPTAN1, STXBP1
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	3	WWOX, PLCB1, PNKP
positive regulation of gene expression (GO:0010628)	2.35	3	WWOX, PLCB1, ARX
regulation of multicellular organismal development (GO:2000026)	2.31	3	DOCK7, CDKL5, PLCB1
cellular response to stress (GO:0033554)	2.51	3	PNKP, AARS, SCN2A
protein transport (GO:0015031)	2.62	3	NECAP1, KCNB1, STXBP1
peptide metabolic process (GO:0006518)	3.44	3	EEF1A2, AARS, SLC25A22
translation (GO:0006412)	3.79	3	EEF1A2, AARS, SLC25A22
negative regulation of cell communication (GO:0010648)	2.66	3	WWOX, KCNB1, STXBP1
positive regulation of secretion (GO:0051047)	3.85	2	KCNB1, STXBP1
vesicle docking involved in exocytosis (GO:0006904)	6.2	2	KCNB1, STXBP1
positive regulation of response to stimulus (GO:0048584)	2.18	2	WWOX, PLCB1
neuron projection morphogenesis (GO:0048812)	4.34	2	SZT2, DOCK7
membrane organization (GO:0061024)	3.04	2	KCNB1, STXBP1
chloride transport (GO:0006821)	5.13	2	SLC12A5, GABRA1
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	AARS, STXBP1
regulation of cell projection organization (GO:0031344)	3.38	2	CDKL5, TBC1D24
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	GRIN2B, SPTAN1
single-organism catabolic process (GO:0044712)	3.21	2	ITPA, PLCB1
neuron projection guidance (GO:0097485)	4.43	2	SPTAN1, ARX
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	PLCB1, ARX
cellular macromolecule localization (GO:0070727)	3.1	2	KCNB1, STXBP1
positive regulation of signal transduction (GO:0009967)	2.5	2	WWOX, PLCB1
MAPK cascade (GO:0000165)	3.91	2	GRIN2B, SPTAN1
regulation of amine transport (GO:0051952)	5.62	2	KCNA2, KCNB1
glycolipid metabolic process (GO:0006664)	5.01	2	PIGA, ST3GAL3
cellular homeostasis (GO:0019725)	3.23	2	SLC12A5, KCNB1
negative regulation of transport (GO:0051051)	3.6	2	GNAO1, KCNB1
regulation of protein complex assembly (GO:0043254)	3.83	2	SPTAN1, STXBP1
negative regulation of cell death (GO:0060548)	2.95	2	AARS, STXBP1
vesicle docking (GO:0048278)	5.7	2	KCNB1, STXBP1
regulation of circadian rhythm (GO:0042752)	5.09	2	KCNA2, SIK1
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	PIGA, PLCB1
axon ensheathment (GO:0008366)	5.48	2	SCN8A, SCN2A
glycerolipid metabolic process (GO:0046486)	3.91	2	PIGA, PLCB1
response to inorganic substance (GO:0010035)	3.56	2	GNAO1, EEF1A2
non-canonical Wnt signaling pathway (GO:0035567)	4.79	2	GNAO1, PLCB1
post-embryonic development (GO:0009791)	5.35	2	SZT2, SCN9A
cell migration (GO:0016477)	3.12	2	CDKL5, ARX
response to external stimulus (GO:0009605)	2.55	2	SIK1, KCNB1
cell motility (GO:0048870)	3.02	2	CDKL5, ARX
positive regulation of organelle organization (GO:0010638)	3.38	2	PLCB1, PNKP
chemical homeostasis (GO:0048878)	2.97	2	SLC12A5, KCNB1
regulation of cell morphogenesis (GO:0022604)	3.4	2	CDKL5, TBC1D24
protein folding (GO:0006457)	4.32	2	GNAO1, AARS
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	CDKL5, TBC1D24
positive regulation of RNA metabolic process (GO:0051254)	2.51	2	WWOX, PLCB1
negative regulation of gene expression (GO:0010629)	2.48	2	PLCB1, ARX
neuron migration (GO:0001764)	5.0	2	CDKL5, ARX
regulation of mitotic cell cycle (GO:0007346)	3.71	2	PLCB1, SIK1
myelination (GO:0042552)	5.52	2	SCN8A, SCN2A
exocytosis (GO:0006887)	4.11	2	KCNB1, STXBP1
protein autophosphorylation (GO:0046777)	4.46	2	CDKL5, SIK1
regulation of immune system process (GO:0002682)	2.5	2	SCN1A, PLCB1
inorganic anion transmembrane transport (GO:0098661)	5.04	2	SLC12A5, GABRA1
sensory perception of pain (GO:0019233)	5.62	2	SCN9A, KCNA2
positive regulation of regulated secretory pathway (GO:1903307)	6.02	2	KCNB1, STXBP1
regulation of regulated secretory pathway (GO:1903305)	4.98	2	KCNB1, STXBP1
apoptotic process (GO:0006915)	3.14	2	WWOX, SCN2A
cell-cell adhesion (GO:0098609)	3.34	2	PCDH19, STXBP1
programmed cell death (GO:0012501)	3.1	2	WWOX, SCN2A
regulation of multi-organism process (GO:0043900)	3.6	2	SCN1A, PLCB1
single-organism membrane organization (GO:0044802)	3.19	2	KCNB1, STXBP1
secretion by cell (GO:0032940)	3.59	2	KCNB1, STXBP1
single-organism carbohydrate metabolic process (GO:0044723)	3.42	2	SLC35A2, ST3GAL3
ephrin receptor signaling pathway (GO:0048013)	5.29	2	GRIN2B, DNM1
negative regulation of neuron death (GO:1901215)	4.57	2	AARS, STXBP1
Wnt signaling pathway, calcium modulating pathway (GO:0007223)	6.12	2	GNAO1, PLCB1
regulation of metal ion transport (GO:0010959)	3.94	2	GNAO1, SIK1
secretion (GO:0046903)	3.38	2	KCNB1, STXBP1
endocytosis (GO:0006897)	3.69	2	NECAP1, DNM1
brain development (GO:0007420)	4.24	2	PCDH19, PLCB1
intracellular transport (GO:0046907)	2.67	2	KCNB1, SPTAN1
positive regulation of protein modification process (GO:0031401)	2.7	2	DOCK7, PLCB1
regulation of transferase activity (GO:0051338)	2.88	2	EEF1A2, PNKP
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	WWOX, ARX
regulation of cell motility (GO:2000145)	3.16	2	DOCK7, PLCB1
nucleoside phosphate metabolic process (GO:0006753)	3.71	2	ITPA, PNKP
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	PLCB1, ARX
regulation of synapse structure or activity (GO:0050803)	4.77	2	KCNB1, STXBP1
response to radiation (GO:0009314)	3.69	2	PNKP, SIK1
modulation of synaptic transmission (GO:0050804)	4.09	2	KCNB1, STXBP1
positive regulation of signaling (GO:0023056)	2.41	2	WWOX, PLCB1
positive regulation of secretion by cell (GO:1903532)	3.93	2	KCNB1, STXBP1
axon guidance (GO:0007411)	4.44	2	SPTAN1, ARX
positive regulation of cell communication (GO:0010647)	2.41	2	WWOX, PLCB1
protein localization to cell periphery (GO:1990778)	4.91	2	KCNB1, STXBP1
regulation of catecholamine secretion (GO:0050433)	5.99	2	KCNA2, KCNB1
regulation of neurogenesis (GO:0050767)	3.21	2	CDKL5, DOCK7
regulation of intracellular signal transduction (GO:1902531)	2.31	2	ARHGEF9, PLCB1
regulation of nervous system development (GO:0051960)	3.1	2	CDKL5, DOCK7
positive regulation of protein metabolic process (GO:0051247)	2.43	2	DOCK7, PLCB1
regulation of cell development (GO:0060284)	3.01	2	CDKL5, DOCK7
regulation of calcium ion-dependent exocytosis (GO:0017158)	5.47	2	KCNB1, STXBP1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	DOCK7, PLCB1
regulation of protein modification process (GO:0031399)	2.32	2	DOCK7, PLCB1
membrane lipid biosynthetic process (GO:0046467)	4.99	2	PIGA, ST3GAL3
biological adhesion (GO:0022610)	2.81	2	PCDH19, STXBP1
regulation of exocytosis (GO:0017157)	4.59	2	KCNB1, STXBP1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	2	WWOX, PLCB1
RNA metabolic process (GO:0016070)	1.59	2	AARS, ARX
phospholipid metabolic process (GO:0006644)	3.88	2	PIGA, PLCB1
membrane lipid metabolic process (GO:0006643)	4.51	2	PIGA, ST3GAL3
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	KCNB1, HCN1
glycolipid biosynthetic process (GO:0009247)	5.6	2	PIGA, ST3GAL3
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	PLCB1, ARX
positive regulation of cell differentiation (GO:0045597)	3.01	2	CDKL5, PLCB1
regulation of locomotion (GO:0040012)	3.12	2	DOCK7, PLCB1
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	PLCB1, ARX
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	2	WWOX, PLCB1
axonogenesis (GO:0007409)	4.74	2	SZT2, DOCK7
cytoskeleton organization (GO:0007010)	3.22	2	DOCK7, SPTAN1
cellular chemical homeostasis (GO:0055082)	3.4	2	SLC12A5, KCNB1
response to oxidative stress (GO:0006979)	3.9	2	GNAO1, PNKP
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	2	ITPA, PNKP
cell part morphogenesis (GO:0032990)	3.99	2	SZT2, DOCK7
homeostatic process (GO:0042592)	2.61	2	SLC12A5, KCNB1
cellular response to organic cyclic compound (GO:0071407)	3.93	2	GABRA1, HCN1
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	PLCB1, ARX
response to drug (GO:0042493)	3.71	2	GNAO1, SLC12A5
regulation of synaptic plasticity (GO:0048167)	4.78	2	KCNB1, STXBP1
regulation of protein phosphorylation (GO:0001932)	2.57	2	DOCK7, PLCB1
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	2	WWOX, PLCB1
positive regulation of exocytosis (GO:0045921)	5.41	2	KCNB1, STXBP1
glycerophospholipid metabolic process (GO:0006650)	4.13	2	PIGA, PLCB1
liposaccharide metabolic process (GO:1903509)	4.98	2	PIGA, ST3GAL3
apoptotic signaling pathway (GO:0097190)	4.12	2	WWOX, SCN2A
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	2	WWOX, SCN2A
membrane docking (GO:0022406)	5.49	2	KCNB1, STXBP1
regulation of muscle cell differentiation (GO:0051147)	4.68	2	PLCB1, SIK1
neuromuscular process (GO:0050905)	5.27	2	SCN1A, AARS
neuron-neuron synaptic transmission (GO:0007270)	5.74	2	GABRA1, DNM1
ensheathment of neurons (GO:0007272)	5.48	2	SCN8A, SCN2A
cell death (GO:0008219)	3.05	2	WWOX, SCN2A
synaptic transmission, GABAergic (GO:0051932)	7.78	2	GABRA1, DNM1
protein homooligomerization (GO:0051260)	4.21	2	KCNA2, KCNB1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	PLCB1, ARX
cellular component morphogenesis (GO:0032989)	3.5	2	SZT2, DOCK7
nitrogen compound transport (GO:0071705)	3.54	2	SLC35A2, SLC25A22
positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.84	2	KCNB1, STXBP1
negative regulation of apoptotic process (GO:0043066)	3.04	2	AARS, STXBP1
inorganic anion transport (GO:0015698)	4.77	2	SLC12A5, GABRA1
negative regulation of programmed cell death (GO:0043069)	3.02	2	AARS, STXBP1
cellular response to nitrogen compound (GO:1901699)	3.79	2	GABRA1, HCN1
regulation of cell migration (GO:0030334)	3.23	2	DOCK7, PLCB1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	PLCB1, ARX
regulation of lipid metabolic process (GO:0019216)	4.08	2	EEF1A2, SIK1
chloride transmembrane transport (GO:1902476)	5.22	2	SLC12A5, GABRA1
cellular protein localization (GO:0034613)	3.11	2	KCNB1, STXBP1
organic substance catabolic process (GO:1901575)	2.45	2	ITPA, PLCB1
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	PLCB1, ARX
nucleotide metabolic process (GO:0009117)	3.73	2	ITPA, PNKP
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	PLCB1, ARX
cell adhesion (GO:0007155)	2.82	2	PCDH19, STXBP1
positive regulation of transferase activity (GO:0051347)	3.31	2	EEF1A2, PNKP
catabolic process (GO:0009056)	2.38	2	ITPA, PLCB1
adult locomotory behavior (GO:0008344)	5.3	2	SCN1A, DNM1
lipid biosynthetic process (GO:0008610)	3.49	2	PIGA, ST3GAL3
locomotion (GO:0040011)	2.91	2	CDKL5, ARX
adult behavior (GO:0030534)	4.79	2	SCN1A, DNM1
regulation of cellular component movement (GO:0051270)	3.08	2	DOCK7, PLCB1
carbohydrate metabolic process (GO:0005975)	3.26	2	SLC35A2, ST3GAL3
cell projection morphogenesis (GO:0048858)	4.05	2	SZT2, DOCK7
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	DOCK7, PLCB1
forebrain development (GO:0030900)	5.48	2	GNAO1, ARX
regulation of synaptic vesicle transport (GO:1902803)	6.29	2	DNM1, STXBP1
regulation of cellular response to stress (GO:0080135)	3.4	2	SZT2, PLCB1
single-organism cellular localization (GO:1902580)	3.16	2	KCNB1, STXBP1
cellular response to organonitrogen compound (GO:0071417)	3.87	2	GABRA1, HCN1
protein localization to membrane (GO:0072657)	3.95	2	KCNB1, STXBP1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of membrane potential (GO:0042391)	-	3.89	0.0	CDKL5, HCN1, SPTAN1, GNAO1, SCN1A, SCN9A, DNM1, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
regulation of transport (GO:0051049)	-	2.24	0.011	KCNA2, KCNB1, HCN1, GNAO1, SCN9A, SCN1A, STXBP1, SIK1, SCN2A, SCN8A, PLCB1, KCNQ2
neuronal action potential (GO:0019228)	-	6.4	0.0	SCN1A, GRIN2B, SCN9A, SCN8A, SCN2A
behavior (GO:0007610)	-	3.47	0.033	ARHGEF9, GNAO1, SCN1A, GABRA1, SCN9A, DNM1, SLC12A5, KCNA2, SCN8A, STXBP1, PLCB1, GRIN2B, KCNQ2
membrane depolarization (GO:0051899)	-	5.62	0.0	CDKL5, SPTAN1, GNAO1, SCN1A, SCN9A, DNM1, SCN2A, GRIN2B, SCN8A
signaling (GO:0023052)	-	3.25	0.001	ARHGEF9, HCN1, SPTAN1, GNAO1, GABRA1, DNM1, KCNB1, SLC12A5, KCNA2, ARX, GRIN2B, STXBP1, PLCB1, SCN8A, KCNQ2
neuromuscular process (GO:0050905)	-	5.27	0.017	GRIN2B, SCN1A, SCN8A, AARS
action potential (GO:0001508)	-	5.42	0.009	SCN9A, SCN1A, SCN2A, SCN8A, GRIN2B, KCNQ2
regulation of ion transmembrane transport (GO:0034765)	-	3.77	0.0	KCNA2, HCN1, SPTAN1, GNAO1, SCN1A, SCN9A, STXBP1, KCNB1, DNM1, SCN2A, GRIN2B, SCN8A, KCNQ2
regulation of ion transport (GO:0043269)	-	3.4	0.001	KCNA2, SPTAN1, HCN1, GNAO1, SCN9A, SCN1A, STXBP1, KCNB1, DNM1, KCNQ2, SCN2A, SCN8A, GRIN2B, SIK1
establishment of localization (GO:0051234)	-	1.48	0.029	ARHGEF9, NECAP1, HCN1, SLC13A5, SCN9A, KCNT1, SCN1A, SLC12A5, DNM1, KCNB1, SLC35A2, KCNQ2, SLC25A22, GABRA1, SCN8A, STXBP1, GRIN2B, KCNA2, SCN2A
cellular potassium ion transport (GO:0071804)	-	4.79	0.006	KCNQ2, KCNT1, HCN1, KCNB1, KCNA2
potassium ion transmembrane transport (GO:0071805)	-	4.79	0.006	KCNA2, KCNT1, KCNQ2, KCNB1, HCN1
localization (GO:0051179)	-	1.4	0.022	ARHGEF9, HCN1, NECAP1, SLC13A5, SCN1A, GABRA1, GRIN2B, SCN9A, SLC35A2, DNM1, KCNB1, SLC12A5, DOCK7, KCNA2, SLC25A22, SCN8A, STXBP1, KCNT1, KCNQ2, SCN2A
sodium ion transmembrane transport (GO:0035725)	-	5.23	0.001	SCN1A, SCN8A, SCN9A, SCN2A, HCN1
regulation of transmembrane transport (GO:0034762)	-	3.74	0.0	KCNA2, HCN1, SPTAN1, GNAO1, SCN9A, SCN1A, STXBP1, KCNB1, DNM1, SCN2A, GRIN2B, SCN8A, KCNQ2
cation transport (GO:0006812)	-	3.11	0.0	SPTAN1, HCN1, SLC13A5, SCN9A, EEF1A2, SCN1A, SLC35A2, STXBP1, KCNB1, GNAO1, SLC12A5, SCN8A, KCNA2, SCN2A, GRIN2B, KCNT1, KCNQ2
monovalent inorganic cation transport (GO:0015672)	-	3.74	0.0	KCNB1, HCN1, SLC13A5, SCN1A, EEF1A2, SCN9A, SLC35A2, SLC12A5, KCNA2, SCN2A, SCN8A, KCNT1, KCNQ2
inorganic cation transmembrane transport (GO:0098662)	-	3.55	0.0	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
potassium ion transport (GO:0006813)	-	4.68	0.001	HCN1, KCNT1, SLC12A5, KCNQ2, KCNB1, KCNA2
neurological system process (GO:0050877)	-	2.64	0.003	ARHGEF9, ST3GAL3, SPTAN1, GNAO1, ARX, SCN1A, DNM1, KCNB1, SLC12A5, SCN8A, KCNA2, AARS, GRIN2B, STXBP1, PLCB1, EEF1A2, KCNQ2
ion transport (GO:0006811)	-	2.66	0.0	HCN1, STXBP1, ARHGEF9, SCN8A, SPTAN1, GNAO1, SCN1A, GABRA1, SCN9A, SLC35A2, DNM1, KCNB1, SLC13A5, SLC12A5, KCNA2, SLC25A22, GRIN2B, EEF1A2, KCNT1, KCNQ2, SCN2A
transport (GO:0006810)	-	1.51	0.02	ARHGEF9, NECAP1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, DNM1, KCNB1, SLC12A5, KCNA2, SLC25A22, GABRA1, SCN8A, STXBP1, GRIN2B, KCNQ2, SCN2A
sodium ion transport (GO:0006814)	-	4.75	0.0	HCN1, SLC13A5, SCN9A, SCN1A, SCN2A, SCN8A
ion transmembrane transport (GO:0034220)	-	3.08	0.0	KCNT1, ARHGEF9, HCN1, SPTAN1, SLC13A5, SCN1A, GABRA1, SCN9A, SLC35A2, STXBP1, KCNB1, SLC12A5, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
single-organism transport (GO:0044765)	-	2.18	0.002	ARHGEF9, SCN2A, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, DNM1, KCNB1, SLC12A5, KCNQ2, SLC25A22, GABRA1, SCN8A, STXBP1, GRIN2B, KCNA2
metal ion transport (GO:0030001)	-	3.36	0.001	KCNT1, KCNB1, HCN1, SLC13A5, SCN1A, EEF1A2, SCN9A, STXBP1, SLC12A5, KCNA2, SCN2A, SCN8A, GRIN2B, KCNQ2
synaptic transmission (GO:0007268)	-	3.98	0.0	ARHGEF9, SPTAN1, HCN1, GNAO1, GABRA1, DNM1, SLC12A5, KCNA2, KCNB1, SCN8A, STXBP1, PLCB1, GRIN2B, KCNQ2
cell-cell signaling (GO:0007267)	-	3.35	0.011	ARHGEF9, HCN1, SPTAN1, KCNA2, GABRA1, STXBP1, KCNB1, GNAO1, SLC12A5, DNM1, ARX, GRIN2B, PLCB1, SCN8A, KCNQ2
cell communication (GO:0007154)	-	3.04	0.005	ARHGEF9, SPTAN1, HCN1, GNAO1, GABRA1, GRIN2B, DNM1, KCNB1, SLC12A5, KCNA2, ARX, SCN8A, STXBP1, PLCB1, EEF1A2, KCNQ2
membrane depolarization during action potential (GO:0086010)	-	6.07	0.001	SCN1A, SCN8A, SCN9A, SCN2A
transmembrane transport (GO:0055085)	-	2.72	0.0	ARHGEF9, HCN1, SPTAN1, SLC13A5, SCN1A, GABRA1, GRIN2B, SCN9A, SLC35A2, STXBP1, KCNB1, SLC12A5, KCNA2, SLC25A22, SCN8A, EEF1A2, KCNT1, KCNQ2, SCN2A
single organism signaling (GO:0044700)	-	3.25	0.001	KCNA2, ARHGEF9, HCN1, SPTAN1, GNAO1, GABRA1, STXBP1, KCNB1, SLC12A5, DNM1, ARX, SCN8A, PLCB1, GRIN2B, KCNQ2
single-organism process (GO:0044699)	-	0.48	0.01	WWOX, ARX, SPTAN1, KCNT1, SCN9A, SLC35A2, DOCK7, AARS, HCN1, GNAO1, EEF1A2, KCNA2, ST3GAL3, GRIN2B, TBC1D24, ITPA, ARHGEF9, SCN2A, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, SLC25A22, PLCB1, SIK1, CDKL5, SZT2, ALG13, PIGA, SLC13A5, SCN8A, GABRA1, KCNQ2
cell projection morphogenesis (GO:0048858)	-	4.05	0.027	SPTAN1, KCNA2, SZT2, STXBP1, DOCK7, DNM1, KCNB1, GRIN2B, KCNQ2
peripheral nervous system development (GO:0007422)	NEW	6.47	0.04	GRIN2B, SPTAN1, SCN8A, KCNQ2
single-organism behavior (GO:0044708)	-	3.79	0.001	KCNA2, ARHGEF9, GNAO1, SCN1A, GABRA1, SCN9A, STXBP1, SLC12A5, DNM1, GRIN2B, PLCB1, SCN8A, KCNQ2
inorganic ion transmembrane transport (GO:0098660)	-	3.38	0.0	ARHGEF9, HCN1, SPTAN1, SCN1A, GABRA1, GRIN2B, SCN9A, STXBP1, KCNB1, SLC12A5, KCNA2, SCN2A, SCN8A, KCNT1, KCNQ2
neuron projection morphogenesis (GO:0048812)	-	4.34	0.037	SPTAN1, KCNA2, SZT2, STXBP1, DOCK7, DNM1, KCNB1, KCNQ2
single-organism cellular process (GO:0044763)	-	0.65	0.0	WWOX, AARS, SPTAN1, KCNT1, SCN9A, PIGA, DOCK7, ARX, HCN1, GNAO1, EEF1A2, SIK1, ST3GAL3, GRIN2B, TBC1D24, ITPA, ARHGEF9, SCN2A, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, SLC25A22, PLCB1, KCNA2, CDKL5, SZT2, ALG13, SLC35A2, SLC13A5, SCN8A, GABRA1, KCNQ2
cation transmembrane transport (GO:0098655)	-	3.43	0.049	KCNB1, HCN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	37	HCN1, WWOX, ARX, NECAP1, KCNT1, SCN9A, PIGA, DOCK7, AARS, SPTAN1, GNAO1, EEF1A2, KCNA2, ST3GAL3, GRIN2B, TBC1D24, ITPA, ARHGEF9, SCN2A, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, SLC25A22, PCDH19, PLCB1, SIK1, CDKL5, SZT2, ALG13, SLC35A2, SLC13A5, SCN8A, GABRA1, KCNQ2
membrane (GO:0016020)	0.68	30	HCN1, WWOX, NECAP1, KCNT1, SCN9A, PIGA, DOCK7, AARS, SPTAN1, GNAO1, ST3GAL3, GRIN2B, SCN2A, PNKP, SCN1A, STXBP1, SLC12A5, DNM1, KCNB1, SLC25A22, PCDH19, PLCB1, KCNA2, CDKL5, GABRA1, ALG13, SLC35A2, SLC13A5, SCN8A, KCNQ2
intracellular part (GO:0044424)	0.28	26	WWOX, AARS, NECAP1, PIGA, DOCK7, ARX, SPTAN1, GNAO1, EEF1A2, KCNA2, ST3GAL3, TBC1D24, ITPA, ARHGEF9, SLC25A22, PNKP, SCN1A, STXBP1, DNM1, PLCB1, SIK1, CDKL5, SZT2, ALG13, SLC35A2, SCN8A
membrane part (GO:0044425)	0.95	25	NECAP1, KCNT1, SCN9A, PIGA, DOCK7, GNAO1, EEF1A2, ST3GAL3, GRIN2B, SCN2A, HCN1, SCN1A, DNM1, SLC12A5, KCNB1, SLC25A22, PCDH19, KCNA2, CDKL5, GABRA1, ALG13, SLC35A2, SLC13A5, SCN8A, KCNQ2
macromolecular complex (GO:0032991)	1.35	20	WWOX, NECAP1, SPTAN1, KCNA2, SCN1A, KCNT1, SCN9A, STXBP1, KCNB1, GNAO1, PIGA, DOCK7, DNM1, SCN2A, GABRA1, SCN8A, EEF1A2, PLCB1, GRIN2B, KCNQ2
cytoplasmic part (GO:0044444)	0.82	20	CDKL5, WWOX, ARHGEF9, SLC25A22, NECAP1, ALG13, SZT2, SCN1A, ITPA, AARS, PIGA, SPTAN1, STXBP1, ST3GAL3, DNM1, SLC35A2, SCN8A, PLCB1, EEF1A2, KCNA2
membrane-bounded organelle (GO:0043227)	0.47	20	KCNA2, CDKL5, WWOX, SLC25A22, PNKP, ARX, SZT2, ALG13, SLC35A2, AARS, PIGA, SPTAN1, STXBP1, ST3GAL3, DNM1, NECAP1, SCN8A, PLCB1, EEF1A2, SIK1
organelle (GO:0043226)	0.4	20	KCNA2, CDKL5, WWOX, SLC25A22, PNKP, ARX, SZT2, ALG13, SLC35A2, AARS, PIGA, SPTAN1, STXBP1, ST3GAL3, DNM1, NECAP1, SCN8A, PLCB1, EEF1A2, SIK1
plasma membrane (GO:0005886)	1.39	20	HCN1, KCNT1, STXBP1, NECAP1, SPTAN1, GNAO1, SCN9A, GABRA1, SCN1A, WWOX, DNM1, KCNB1, SLC13A5, SLC12A5, PCDH19, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
protein complex (GO:0043234)	1.51	19	WWOX, STXBP1, NECAP1, SPTAN1, GNAO1, SCN1A, GABRA1, GRIN2B, SCN9A, DNM1, KCNB1, PIGA, DOCK7, KCNA2, SCN2A, SCN8A, EEF1A2, KCNT1, KCNQ2
integral component of membrane (GO:0016021)	1.14	19	SLC35A2, SLC25A22, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC12A5, KCNB1, PCDH19, PIGA, DOCK7, KCNA2, ST3GAL3, GABRA1, GRIN2B, SCN8A, KCNQ2, SCN2A
intracellular membrane-bounded organelle (GO:0043231)	0.6	19	CDKL5, WWOX, STXBP1, AARS, SPTAN1, SZT2, ST3GAL3, ALG13, SLC35A2, DNM1, PNKP, PIGA, KCNA2, ARX, SLC25A22, SCN8A, PLCB1, EEF1A2, SIK1
intracellular organelle (GO:0043229)	0.51	19	CDKL5, WWOX, ST3GAL3, PNKP, KCNA2, SZT2, ALG13, SLC35A2, AARS, DNM1, PIGA, SPTAN1, STXBP1, ARX, SLC25A22, SCN8A, PLCB1, EEF1A2, SIK1
intrinsic component of membrane (GO:0031224)	1.13	19	ST3GAL3, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, SLC35A2, KCNB1, PCDH19, PIGA, DOCK7, KCNQ2, SLC25A22, SLC12A5, GABRA1, SCN8A, GRIN2B, KCNA2, SCN2A
organelle part (GO:0044422)	0.79	18	CDKL5, WWOX, NECAP1, PNKP, ALG13, EEF1A2, SCN1A, SLC35A2, STXBP1, PIGA, SPTAN1, DNM1, ST3GAL3, SLC25A22, DOCK7, SCN8A, PLCB1, KCNA2
intracellular organelle part (GO:0044446)	0.81	16	CDKL5, WWOX, NECAP1, SPTAN1, EEF1A2, ALG13, SLC35A2, DNM1, PNKP, PIGA, DOCK7, STXBP1, ST3GAL3, SLC25A22, PLCB1, KCNA2
neuron part (GO:0097458)	2.64	16	KCNA2, CDKL5, KCNB1, HCN1, GNAO1, EEF1A2, SCN1A, STXBP1, SLC12A5, DOCK7, DNM1, SCN2A, SCN8A, TBC1D24, GRIN2B, KCNQ2
plasma membrane part (GO:0044459)	1.95	15	CDKL5, KCNB1, HCN1, SLC13A5, SCN1A, KCNT1, SCN9A, GNAO1, SLC12A5, KCNA2, SCN2A, GABRA1, SCN8A, GRIN2B, KCNQ2
membrane protein complex (GO:0098796)	2.84	13	KCNB1, NECAP1, GNAO1, SCN1A, KCNT1, SCN9A, DNM1, KCNA2, SCN2A, GABRA1, GRIN2B, SCN8A, KCNQ2
cytoplasm (GO:0005737)	1.01	12	CDKL5, WWOX, ARHGEF9, SPTAN1, TBC1D24, EEF1A2, ITPA, STXBP1, DNM1, AARS, PLCB1, SIK1
cell projection part (GO:0044463)	2.97	11	CDKL5, KCNA2, SCN1A, STXBP1, SLC12A5, DOCK7, DNM1, SCN2A, SCN8A, TBC1D24, KCNQ2
plasma membrane protein complex (GO:0098797)	3.55	10	KCNB1, GNAO1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
ion channel complex (GO:0034702)	4.18	10	KCNB1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, GABRA1, GRIN2B, SCN8A, KCNQ2
transporter complex (GO:1990351)	4.04	10	KCNB1, SCN1A, KCNT1, GRIN2B, SCN9A, KCNA2, SCN2A, SCN8A, GABRA1, KCNQ2
cell projection (GO:0042995)	2.47	10	WWOX, KCNB1, HCN1, GNAO1, SCN9A, SCN1A, DOCK7, SCN2A, GRIN2B, KCNA2
transmembrane transporter complex (GO:1902495)	4.06	10	KCNB1, SCN1A, KCNT1, SCN9A, KCNQ2, SCN2A, GABRA1, GRIN2B, SCN8A, KCNA2
vesicle (GO:0031982)	1.64	8	NECAP1, SPTAN1, SZT2, STXBP1, DNM1, AARS, SCN8A, PLCB1
nucleus (GO:0005634)	1.07	8	CDKL5, PNKP, EEF1A2, WWOX, SLC35A2, ARX, PLCB1, SIK1
cation channel complex (GO:0034703)	4.69	8	KCNB1, SCN9A, KCNT1, SCN1A, KCNA2, SCN2A, SCN8A, KCNQ2
neuron projection (GO:0043005)	3.12	8	KCNB1, HCN1, GNAO1, SCN1A, DOCK7, SCN2A, GRIN2B, KCNA2
axon part (GO:0033267)	4.4	8	KCNA2, SCN1A, DNM1, STXBP1, SCN2A, SCN8A, TBC1D24, KCNQ2
integral component of plasma membrane (GO:0005887)	2.57	8	HCN1, SLC13A5, GABRA1, SCN9A, SLC12A5, SCN2A, GRIN2B, KCNA2
intrinsic component of plasma membrane (GO:0031226)	2.53	8	HCN1, SLC13A5, GABRA1, SCN9A, SLC12A5, SCN2A, GRIN2B, KCNA2
cytosol (GO:0005829)	1.68	7	ITPA, ARHGEF9, SPTAN1, WWOX, STXBP1, AARS, PLCB1
synapse part (GO:0044456)	3.42	7	GABRA1, DNM1, STXBP1, KCNB1, GRIN2B, TBC1D24, KCNA2
nuclear part (GO:0044428)	1.55	7	CDKL5, PNKP, WWOX, STXBP1, DOCK7, SLC25A22, PLCB1
cell junction (GO:0030054)	2.75	7	SCN2A, GABRA1, SCN1A, DOCK7, KCNB1, GRIN2B, KCNA2
membrane-bounded vesicle (GO:0031988)	1.71	7	SPTAN1, SZT2, STXBP1, DNM1, AARS, SCN8A, PLCB1
extracellular organelle (GO:0043230)	1.89	6	SPTAN1, SZT2, STXBP1, DNM1, AARS, PLCB1
extracellular exosome (GO:0070062)	1.89	6	SPTAN1, SZT2, STXBP1, DNM1, AARS, PLCB1
axon (GO:0030424)	4.15	6	SCN2A, HCN1, SCN1A, DOCK7, KCNB1, KCNA2
synapse (GO:0045202)	3.58	6	GABRA1, DNM1, KCNB1, GRIN2B, TBC1D24, KCNA2
extracellular vesicle (GO:1903561)	1.89	6	SPTAN1, SZT2, STXBP1, DNM1, AARS, PLCB1
extracellular region part (GO:0044421)	1.57	6	SPTAN1, SZT2, STXBP1, DNM1, AARS, PLCB1
myelin sheath (GO:0043209)	4.76	5	GNAO1, EEF1A2, PLCB1, DNM1, STXBP1
plasma membrane region (GO:0098590)	2.97	5	KCNA2, GRIN2B, GABRA1, KCNB1, CDKL5
organelle membrane (GO:0031090)	1.97	5	SLC35A2, PLCB1, NECAP1, ST3GAL3, SLC25A22
synaptic membrane (GO:0097060)	4.22	4	KCNA2, GRIN2B, GABRA1, KCNB1
Golgi apparatus (GO:0005794)	2.7	4	SLC35A2, WWOX, DNM1, ST3GAL3
endoplasmic reticulum (GO:0005783)	2.56	4	PIGA, ALG13, SLC35A2, KCNA2
cytoplasmic vesicle (GO:0031410)	2.87	4	SCN8A, DNM1, NECAP1, STXBP1
cell body (GO:0044297)	3.74	4	GNAO1, SLC12A5, SCN1A, EEF1A2
voltage-gated potassium channel complex (GO:0008076)	5.34	4	KCNA2, KCNT1, KCNB1, KCNQ2
dendrite (GO:0030425)	3.92	4	GNAO1, KCNA2, KCNB1, HCN1
intracellular (GO:0005622)	2.37	4	GRIN2B, DOCK7, KCNB1, SCN2A
nucleoplasm (GO:0005654)	1.89	4	PNKP, CDKL5, STXBP1, SLC25A22
mitochondrion (GO:0005739)	2.42	4	AARS, WWOX, SLC25A22, STXBP1
potassium channel complex (GO:0034705)	5.32	4	KCNA2, KCNT1, KCNB1, KCNQ2
intracellular vesicle (GO:0097708)	2.86	4	SCN8A, DNM1, NECAP1, STXBP1
node of Ranvier (GO:0033268)	7.09	4	SCN8A, SCN1A, SCN2A, KCNQ2
sodium channel complex (GO:0034706)	6.97	4	SCN9A, SCN8A, SCN1A, SCN2A
voltage-gated sodium channel complex (GO:0001518)	7.16	4	SCN9A, SCN8A, SCN1A, SCN2A
axon initial segment (GO:0043194)	7.32	3	SCN8A, SCN1A, KCNQ2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	3	PNKP, DNM1, SPTAN1
postsynaptic membrane (GO:0045211)	4.47	3	GRIN2B, GABRA1, KCNB1
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	SCN8A, DNM1, STXBP1
bounding membrane of organelle (GO:0098588)	2.39	3	SLC35A2, NECAP1, ST3GAL3
endoplasmic reticulum membrane (GO:0005789)	2.95	3	PIGA, ALG13, KCNA2
endoplasmic reticulum part (GO:0044432)	2.73	3	PIGA, ALG13, KCNA2
non-membrane-bounded organelle (GO:0043228)	1.76	3	PNKP, DNM1, SPTAN1
neuronal cell body (GO:0043025)	3.9	3	SLC12A5, SCN1A, EEF1A2
site of polarized growth (GO:0030427)	4.85	2	CDKL5, DOCK7
growth cone (GO:0030426)	4.89	2	CDKL5, DOCK7
neuronal cell body membrane (GO:0032809)	6.81	2	KCNA2, KCNB1
intercalated disc (GO:0014704)	5.93	2	SCN1A, SCN2A
membrane coat (GO:0030117)	5.68	2	DNM1, NECAP1
Z disc (GO:0030018)	5.11	2	SCN8A, SCN1A
cytoskeleton (GO:0005856)	2.55	2	DNM1, SPTAN1
perikaryon (GO:0043204)	5.13	2	KCNA2, KCNB1
Golgi apparatus part (GO:0044431)	3.0	2	SLC35A2, ST3GAL3
cytoskeletal part (GO:0044430)	2.49	2	DNM1, SPTAN1
cell body membrane (GO:0044298)	6.81	2	KCNA2, KCNB1
secretory vesicle (GO:0099503)	4.0	2	DNM1, STXBP1
T-tubule (GO:0030315)	6.09	2	SCN1A, SCN2A
leading edge membrane (GO:0031256)	4.9	2	CDKL5, KCNA2
cell-cell contact zone (GO:0044291)	5.69	2	SCN1A, SCN2A
cytoplasmic region (GO:0099568)	4.51	2	CDKL5, SPTAN1
cell projection membrane (GO:0031253)	4.11	2	CDKL5, KCNA2
cell-cell junction (GO:0005911)	3.85	2	SCN1A, SCN2A
receptor complex (GO:0043235)	4.01	2	GRIN2B, GABRA1
terminal bouton (GO:0043195)	5.63	2	TBC1D24, STXBP1
Golgi membrane (GO:0000139)	3.28	2	SLC35A2, ST3GAL3
presynapse (GO:0098793)	4.97	2	TBC1D24, STXBP1
contractile fiber part (GO:0044449)	4.53	2	SCN8A, SCN1A

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
dendrite (GO:0030425)	-	3.92	0.003	KCNA2, HCN1, SPTAN1, GNAO1, STXBP1, DNM1, KCNB1, GRIN2B, SCN8A, KCNQ2
axon (GO:0030424)	-	4.15	0.038	KCNB1, HCN1, EEF1A2, STXBP1, DOCK7, SCN2A, GRIN2B
sodium channel complex (GO:0034706)	-	6.97	0.0	SCN9A, SCN8A, SCN1A, SCN2A
potassium channel complex (GO:0034705)	-	5.32	0.002	KCNA2, KCNT1, KCNB1, KCNQ2
ion channel complex (GO:0034702)	-	4.18	0.0	ARHGEF9, KCNB1, SPTAN1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, GABRA1, GRIN2B, SCN8A, KCNQ2
cation channel complex (GO:0034703)	-	4.69	0.0	KCNB1, SCN1A, KCNT1, SCN9A, KCNA2, SCN2A, GRIN2B, SCN8A, KCNQ2
membrane (GO:0016020)	-	0.68	0.009	SPTAN1, KCNT1, SCN9A, PIGA, AARS, NECAP1, GNAO1, ST3GAL3, GRIN2B, SCN2A, HCN1, SCN1A, STXBP1, SLC12A5, KCNB1, SLC25A22, PCDH19, PLCB1, KCNA2, GABRA1, ALG13, SLC35A2, PNKP, SLC13A5, SCN8A, KCNQ2
neuron part (GO:0097458)	-	2.64	0.005	KCNA2, CDKL5, ARHGEF9, SPTAN1, HCN1, GNAO1, EEF1A2, SCN1A, STXBP1, KCNB1, SLC12A5, DOCK7, DNM1, SCN2A, SCN8A, GRIN2B, KCNQ2
neuron projection (GO:0043005)	-	3.12	0.015	KCNB1, HCN1, GNAO1, DOCK7, SCN2A, SCN8A, GRIN2B
plasma membrane part (GO:0044459)	-	1.95	0.007	WWOX, SPTAN1, KCNT1, SCN9A, SLC35A2, GNAO1, EEF1A2, SCN2A, GRIN2B, ARHGEF9, HCN1, SCN1A, STXBP1, DNM1, KCNB1, PLCB1, KCNA2, GABRA1, PIGA, SLC13A5, SCN8A, KCNQ2
transmembrane transporter complex (GO:1902495)	-	4.06	0.0	ARHGEF9, KCNB1, SPTAN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, GABRA1, SCN8A, GRIN2B, KCNQ2
transporter complex (GO:1990351)	-	4.04	0.0	ARHGEF9, KCNB1, SPTAN1, SCN1A, KCNT1, SCN9A, STXBP1, KCNA2, SCN2A, GABRA1, SCN8A, GRIN2B, KCNQ2
cell body (GO:0044297)	-	3.74	0.002	SPTAN1, GNAO1, EEF1A2, SCN1A, DNM1, SLC12A5, KCNA2, KCNB1, GRIN2B, SCN8A, KCNQ2
voltage-gated potassium channel complex (GO:0008076)	-	5.34	0.002	KCNA2, KCNT1, KCNB1, KCNQ2
postsynaptic membrane (GO:0045211)	-	4.47	0.036	SPTAN1, GABRA1, STXBP1, DNM1, KCNB1, GRIN2B, KCNQ2
neuron projection membrane (GO:0032589)	NEW	6.19	0.01	KCNQ2, GRIN2B, KCNB1, KCNA2
voltage-gated sodium channel complex (GO:0001518)	-	7.16	0.0	SCN9A, SCN8A, SCN1A, SCN2A
axon initial segment (GO:0043194)	-	7.32	0.0	SCN8A, SCN1A, KCNQ2
neuronal cell body (GO:0043025)	-	3.9	0.0	SPTAN1, GNAO1, EEF1A2, SCN1A, DNM1, SLC12A5, KCNA2, KCNB1, GRIN2B, SCN8A, KCNQ2
cell projection part (GO:0044463)	-	2.97	0.035	KCNA2, CDKL5, KCNB1, SPTAN1, GNAO1, SCN1A, STXBP1, SLC12A5, DOCK7, DNM1, SCN2A, SCN8A, GRIN2B, KCNQ2
axon part (GO:0033267)	-	4.4	0.001	KCNA2, SCN8A, SCN1A, SCN2A, KCNQ2
node of Ranvier (GO:0033268)	-	7.09	0.0	SCN8A, SCN1A, SCN2A, KCNQ2
synapse (GO:0045202)	-	3.58	0.029	STXBP1, SPTAN1, GABRA1, DNM1, KCNA2, KCNB1, GRIN2B, KCNQ2