Disease table of ATRIAL FIBRILLATION, FAMILIAL OMIM ID: PS608583

Gene-disease associations table

GeneAssociated with ATRIAL FIBRILLATION, FAMILIAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
KCNE2ClinVar, OMIM, HUMSAVARHGNC link21q22.113PS192500, PS608583, 115000
KCNJ2ClinVar, OMIM, HUMSAVARHGNC link17q24.34PS609620, PS608583, 115000, PS192500
SCN4BClinVar, OMIM, HUMSAVARHGNC link11q23.34272120, PS608583, 115000, PS192500
GJA5ClinVar, OMIM, HUMSAVARHGNC link1q21.22PS608583, 108770
SCN5AClinVar, OMIM, HUMSAVARHGNC link3p22.211272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567
KCNQ1ClinVar, OMIM, HUMSAVARHGNC link11p15.56115000, 272120, PS609620, PS608583, PS192500, 220400
SCN2BClinVar, OMIM, HUMSAVARHGNC link11q23.31PS608583
SCN1BClinVar, OMIM, HUMSAVARHGNC link19q13.114PS601144, PS608583, 115000, PS604233
ABCC9ClinVar, OMIM, HUMSAVARHGNC link12p12.13PS115200, 239850, PS608583
NUP155ClinVar, OMIM, HUMSAVARHGNC link5p13.21PS608583
KCNA5ClinVar, OMIMHGNC link12p13.322PS178600, PS608583
SCN3BClinVar, OMIM, HUMSAVARHGNC link11q24.12PS601144, PS608583
NPPAClinVar, OMIMHGNC link1p36.223115000, PS608583, 615745

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
11q23.32SCN4B, SCN2B
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
11q232SCN4B, SCN2B
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
12p12KCNA5, ABCC9
11q23SCN4B, SCN3B, SCN2B
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
12p2KCNA5, ABCC9
11q3SCN4B, SCN3B, SCN2B
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
114SCN4B, SCN3B, KCNQ1, SCN2B
122KCNA5, ABCC9
12GJA5, NPPA
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TBX5NO5ITGA9, CDKN2A, NPPA, GJA5, MYH62NPPA, GJA5
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GJA5YES1TBX50
NPPAYES7JARID2, GATA4, TBX5, NKX2-2, ANKRD1, FOS, HAND20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
KCNE2KCNQ1Yes1ATP4A
KCNJ2KCNA5No2DLG4, DLG1
GJA5NPPANo1UBQLN4
SCN5AKCNQ1No1NEDD4
SCN5AKCNA5No1SNTA1
NUP155KCNA5No1UBE2I

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
GJA5NPPANo-2TBX5, GATA4
SCN2BSCN1BYesbinding9SCN10A, SCN9A, SCN3B, SCNN1A, SCN3A, SCN2A, SCN8A, SCNN1G, SCNN1B
SCN2BKCNA5No-0
SCN2BSCN3BYesbinding8SCN10A, SCNN1A, SCN3A, SCN1B, SCN2A, SCN8A, SCNN1G, SCNN1B
SCN1BKCNA5No-0
SCN1BSCN3BYesbinding8SCN2B, SCN10A, SCNN1A, SCN3A, SCN2A, SCN8A, SCNN1G, SCNN1B
KCNA5SCN3BNo-0
KCNA5NPPANo-1SRC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
SCN5AKCNQ1No4CALM1, CALM2, CALM3, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Adrenergic signaling in cardiomyocyteshsa042615.444KCNQ1, SCN5A, SCN4B, SCN1B
Gastric acid secretionhsa049716.483KCNJ2, KCNQ1, KCNE2
Cholinergic synapsehsa047255.882KCNJ2, KCNQ1

NET-GE enrichment

Term New enriched termICP valueGenes
Gastric acid secretion (hsa04971) -6.480.001KCNJ2, KCNQ1, KCNA5, KCNE2
Circulatory systemNEW4.630.006SCN5A, KCNQ1, KCNA5, NPPA, SCN4B, SCN1B
Adrenergic signaling in cardiomyocytes (hsa04261) -5.440.001KCNQ1, SCN4B, SCN5A, KCNA5, SCN1B
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Axon guidanceR-HSA-4224753.935SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
Interaction between L1 and AnkyrinsR-HSA-4450958.035SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
L1CAM interactionsR-HSA-3737606.195SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
Developmental BiologyR-HSA-12667383.485SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
Neuronal SystemR-HSA-1123164.824KCNJ2, ABCC9, KCNA5, KCNQ1
Potassium ChannelsR-HSA-12960716.354KCNJ2, ABCC9, KCNA5, KCNQ1
DiseaseR-HSA-16436853.333ABCC9, NUP155, NPPA
Inwardly rectifying K+ channelsR-HSA-12960658.032KCNJ2, ABCC9
Gene ExpressionR-HSA-741602.722NUP155, NPPA
Voltage gated Potassium channelsR-HSA-12960727.562KCNQ1, KCNA5
Transmembrane transport of small moleculesR-HSA-3825513.792ABCC9, NUP155

NET-GE enrichment

Term New enriched termICP valueGenes
Neuronal System (R-HSA-112316) -4.820.046KCNJ2, ABCC9, KCNA5, KCNQ1
Axon guidance (R-HSA-422475) -3.930.048SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
Interaction between L1 and Ankyrins (R-HSA-445095) -8.030.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
L1CAM interactions (R-HSA-373760) -6.190.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
Potassium Channels (R-HSA-1296071) -6.350.004KCNJ2, ABCC9, KCNA5, KCNQ1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
transporter activity (GO:0005215) 2.5712SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, KCNA5, SCN4B, SCN1B
passive transmembrane transporter activity (GO:0022803) 3.611SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, KCNA5, SCN4B, SCN1B
transmembrane transporter activity (GO:0022857) 2.8211SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
channel activity (GO:0015267) 3.611SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
binding (GO:0005488) 0.1811SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, KCNA5, SCN4B
protein binding (GO:0005515) 0.4611SCN4B, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, SCN5A
substrate-specific transmembrane transporter activity (GO:0022891) 2.910SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890) 3.4910SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
substrate-specific transporter activity (GO:0022892) 2.7210SCN2B, SCN4B, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, ABCC9, SCN5A, SCN1B
cation channel activity (GO:0005261) 4.0410SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
ion channel activity (GO:0005216) 3.7110SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
cation transmembrane transporter activity (GO:0008324) 3.3210SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
ion transmembrane transporter activity (GO:0015075) 3.0410SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.8710SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
metal ion transmembrane transporter activity (GO:0046873) 3.7110SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
substrate-specific channel activity (GO:0022838) 3.6710SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
voltage-gated channel activity (GO:0022832) 4.499SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, KCNA5, SCN4B, SCN1B
voltage-gated ion channel activity (GO:0005244) 4.499SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, KCNA5, SCN4B, SCN1B
gated channel activity (GO:0022836) 3.969SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, SCN4B, SCN1B
channel regulator activity (GO:0016247) 4.887SCN2B, SCN4B, KCNE2, SCN3B, ABCC9, KCNA5, SCN1B
molecular function regulator (GO:0098772) 2.517SCN2B, SCN4B, KCNE2, SCN3B, ABCC9, KCNA5, SCN1B
ion channel binding (GO:0044325) 5.026SCN4B, KCNQ1, SCN3B, KCNE2, ABCC9, SCN5A
potassium channel activity (GO:0005267) 4.945KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
sodium channel activity (GO:0005272) 6.135SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
sodium ion transmembrane transporter activity (GO:0015081) 4.835SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) 8.135SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
voltage-gated sodium channel activity (GO:0005248) 6.745SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030) 6.745SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
potassium ion transmembrane transporter activity (GO:0015079) 4.775KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
sodium channel regulator activity (GO:0017080) 6.34SCN2B, SCN4B, SCN3B, SCN1B
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) 7.794KCNJ2, KCNQ1, KCNA5, KCNE2
voltage-gated cation channel activity (GO:0022843) 4.834KCNJ2, KCNQ1, KCNA5, KCNE2
voltage-gated potassium channel activity (GO:0005249) 5.244KCNJ2, KCNQ1, KCNA5, KCNE2
kinase binding (GO:0019900) 3.323KCNQ1, SCN5A, KCNA5
potassium channel regulator activity (GO:0015459) 5.933ABCC9, KCNA5, KCNE2
enzyme binding (GO:0019899) 2.273KCNQ1, SCN5A, KCNA5
protein kinase binding (GO:0019901) 3.443KCNQ1, SCN5A, KCNA5
molecular transducer activity (GO:0060089) 2.323KCNJ2, ABCC9, KCNE2
scaffold protein binding (GO:0097110) 5.933KCNQ1, SCN5A, KCNA5
receptor activity (GO:0004872) 2.323KCNJ2, ABCC9, KCNE2
delayed rectifier potassium channel activity (GO:0005251) 6.153KCNQ1, KCNA5, KCNE2
transmembrane receptor activity (GO:0099600) 2.533KCNJ2, ABCC9, KCNE2
ligand-gated channel activity (GO:0022834) 4.82KCNJ2, KCNE2
cytoskeletal protein binding (GO:0008092) 3.022SCN5A, KCNA5
phosphatidylinositol binding (GO:0035091) 4.472KCNJ2, KCNQ1
voltage-gated sodium channel activity involved in Purkinje myocyte action potential (GO:0086062) 9.052SCN5A, SCN1B
outward rectifier potassium channel activity (GO:0015271) 7.442KCNQ1, KCNA5
phospholipid binding (GO:0005543) 3.912KCNJ2, KCNQ1
ligand-gated ion channel activity (GO:0015276) 4.82KCNJ2, KCNE2
phosphatidylinositol-4,5-bisphosphate binding (GO:0005546) 5.812KCNJ2, KCNQ1
lipid binding (GO:0008289) 3.262KCNJ2, KCNQ1
phosphatidylinositol bisphosphate binding (GO:1902936) 5.792KCNJ2, KCNQ1
calmodulin binding (GO:0005516) 4.552KCNQ1, SCN5A
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) 8.352KCNQ1, KCNE2
phosphatidylinositol phosphate binding (GO:1901981) 5.052KCNJ2, KCNQ1
channel inhibitor activity (GO:0016248) 6.132KCNA5, SCN1B
receptor binding (GO:0005102) 2.432KCNA5, NPPA
ion channel inhibitor activity (GO:0008200) 6.152KCNA5, SCN1B
inward rectifier potassium channel activity (GO:0005242) 6.652KCNJ2, KCNE2
identical protein binding (GO:0042802) 2.632KCNJ2, KCNE2
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization (GO:0086089) 9.052KCNQ1, KCNA5

NET-GE enrichment

Term New enriched termICP valueGenes
potassium channel activity (GO:0005267) -4.940.0KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
cation channel activity (GO:0005261) -4.040.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
ion channel binding (GO:0044325) -5.020.0SCN5A, KCNQ1, KCNE2, KCNA5, SCN3B, ABCC9, SCN4B
substrate-specific channel activity (GO:0022838) -3.670.0SCN2B, SCN4B, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, NPPA, ABCC9, SCN5A, SCN1B
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) -8.130.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
sodium ion transmembrane transporter activity (GO:0015081) -4.830.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
sodium channel inhibitor activity (GO:0019871) NEW8.130.003SCN5A, SCN1B
outward rectifier potassium channel activity (GO:0015271) -7.440.003KCNQ1, KCNA5
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) -7.790.0KCNJ2, KCNQ1, KCNA5, KCNE2
transmembrane transporter activity (GO:0022857) -2.820.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization (GO:0086089) -9.050.0KCNQ1, KCNA5
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) -8.350.0KCNQ1, KCNE2
channel inhibitor activity (GO:0016248) -6.130.029SCN5A, KCNA5, SCN1B
channel regulator activity (GO:0016247) -4.880.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, SCN3B, ABCC9, SCN4B, SCN1B
delayed rectifier potassium channel activity (GO:0005251) -6.150.027KCNQ1, KCNA5
metal ion transmembrane transporter activity (GO:0046873) -3.710.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
potassium channel regulator activity (GO:0015459) -5.930.0ABCC9, KCNQ1, KCNA5, KCNE2
voltage-gated cation channel activity (GO:0022843) -4.830.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, SCN4B, SCN1B
sodium channel activity (GO:0005272) -6.130.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
transporter activity (GO:0005215) -2.570.0SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
ion channel activity (GO:0005216) -3.710.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, ABCC9, KCNA5, SCN4B, SCN1B
cation transmembrane transporter activity (GO:0008324) -3.320.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
passive transmembrane transporter activity (GO:0022803) -3.60.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, KCNA5, SCN4B, SCN1B
ion channel inhibitor activity (GO:0008200) -6.150.004SCN5A, KCNA5, SCN1B
substrate-specific transmembrane transporter activity (GO:0022891) -2.90.0SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, KCNA5, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890) -3.490.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
substrate-specific transporter activity (GO:0022892) -2.720.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, KCNA5, SCN4B, SCN1B
ion transmembrane transporter activity (GO:0015075) -3.040.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
voltage-gated channel activity (GO:0022832) -4.490.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, KCNA5, SCN4B, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077) -3.870.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
channel activity (GO:0015267) -3.60.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, KCNA5, SCN4B, SCN1B
scaffold protein binding (GO:0097110) -5.930.005KCNQ1, SCN5A, KCNA5
gated channel activity (GO:0022836) -3.960.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, SCN4B, SCN1B
voltage-gated potassium channel activity (GO:0005249) -5.240.001KCNJ2, KCNQ1, KCNA5, KCNE2
voltage-gated sodium channel activity (GO:0005248) -6.740.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
sodium channel regulator activity (GO:0017080) -6.30.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
voltage-gated ion channel activity (GO:0005244) -4.490.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, SCN4B, SCN1B
potassium ion transmembrane transporter activity (GO:0015079) -4.770.0KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.3913SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
regulation of biological process (GO:0050789) 0.4513SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
single-organism process (GO:0044699) 0.4813SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
regulation of membrane potential (GO:0042391) 3.8912SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, SCN4B, SCN1B
cellular process (GO:0009987) 0.2612SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, KCNA5, SCN1B
regulation of biological quality (GO:0065008) 1.6812SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, SCN4B, SCN1B
regulation of system process (GO:0044057) 3.5312SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
regulation of transport (GO:0051049) 2.2412SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, KCNA5, SCN4B, SCN1B
transport (GO:0006810) 1.5112SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, ABCC9, SCN4B, SCN1B
regulation of cellular process (GO:0050794) 0.512SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, KCNA5, SCN1B
regulation of heart contraction (GO:0008016) 4.3512SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, KCNA5, SCN4B, SCN1B
single-organism cellular process (GO:0044763) 0.6512SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, KCNA5, SCN1B
regulation of multicellular organismal process (GO:0051239) 1.8712SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
regulation of blood circulation (GO:1903522) 4.0512SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
regulation of localization (GO:0032879) 1.9412SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, KCNA5, SCN1B
establishment of localization (GO:0051234) 1.4812SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, KCNA5, SCN4B, SCN1B
localization (GO:0051179) 1.412SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, KCNA5, SCN1B
multicellular organismal process (GO:0032501) 1.4511SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, SCN4B, SCN1B
cardiac muscle cell action potential (GO:0086001) 6.3311SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, SCN4B, SCN1B
cardiac muscle cell action potential involved in contraction (GO:0086002) 6.4711SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, KCNA5, SCN1B
cation transport (GO:0006812) 3.1111SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
ion transport (GO:0006811) 2.6611SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, KCNA5, SCN1B
transmembrane transport (GO:0055085) 2.7211SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
regulation of heart rate (GO:0002027) 5.2911SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, SCN4B, SCN1B
metal ion transport (GO:0030001) 3.3611SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, KCNA5, SCN4B, SCN1B
regulation of transmembrane transport (GO:0034762) 3.7411SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, KCNA5, SCN4B, SCN1B
action potential (GO:0001508) 5.4211SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, SCN4B, SCN1B
regulation of ion transmembrane transport (GO:0034765) 3.7711SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, SCN4B, SCN1B
monovalent inorganic cation transport (GO:0015672) 3.7411SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
regulation of ion transport (GO:0043269) 3.411SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, SCN4B, SCN1B
single organism signaling (GO:0044700) 3.2510SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, KCNA5, SCN1B
cardiac conduction (GO:0061337) 5.5410SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, KCNA5, SCN1B
single-multicellular organism process (GO:0044707) 1.7810SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, KCNA5, SCN1B
regulation of metal ion transport (GO:0010959) 3.9410SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, KCNA5, SCN4B, SCN1B
ion transmembrane transport (GO:0034220) 3.0810SCN2B, SCN4B, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, ABCC9, SCN5A, SCN1B
regulation of heart rate by cardiac conduction (GO:0086091) 6.3310SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, KCNA5, SCN4B, SCN1B
signaling (GO:0023052) 3.2510SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, SCN4B, SCN1B
inorganic cation transmembrane transport (GO:0098662) 3.5510SCN2B, SCN4B, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, ABCC9, SCN5A, SCN1B
inorganic ion transmembrane transport (GO:0098660) 3.3810SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
positive regulation of biological process (GO:0048518) 1.210SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, SCN4B, SCN1B
cation transmembrane transport (GO:0098655) 3.4310SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
multicellular organismal signaling (GO:0035637) 5.3610SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, SCN4B, SCN1B
system process (GO:0003008) 2.310SCN2B, SCN5A, KCNQ1, GJA5, KCNJ2, SCN3B, NPPA, KCNA5, SCN4B, SCN1B
response to stimulus (GO:0050896) 1.229SCN2B, KCNA5, KCNQ1, KCNE2, KCNJ2, NPPA, ABCC9, SCN5A, SCN1B
regulation of cation transmembrane transport (GO:1904062) 4.49SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, SCN4B, SCN1B
regulation of membrane repolarization (GO:0060306) 6.49SCN5A, SCN4B, KCNQ1, GJA5, KCNJ2, KCNE2, NPPA, KCNA5, SCN1B
positive regulation of ion transport (GO:0043270) 4.368SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, SCN5A, SCN1B
muscle system process (GO:0003012) 4.188SCN2B, SCN4B, KCNQ1, SCN3B, KCNJ2, NPPA, SCN5A, SCN1B
positive regulation of transport (GO:0051050) 2.98SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, SCN5A, SCN1B
regulation of cardiac muscle cell membrane repolarization (GO:0099623) 6.688SCN5A, SCN4B, KCNQ1, GJA5, KCNE2, NPPA, KCNA5, SCN1B
positive regulation of cellular process (GO:0048522) 1.38SCN5A, KCNQ1, GJA5, KCNJ2, KCNE2, NPPA, KCNA5, SCN1B
developmental process (GO:0032502) 1.367SCN2B, SCN5A, KCNQ1, SCN3B, KCNE2, GJA5, NPPA
regulation of ion transmembrane transporter activity (GO:0032412) 4.557SCN2B, SCN4B, KCNQ1, SCN3B, KCNE2, NPPA, SCN1B
regulation of transmembrane transporter activity (GO:0022898) 4.527SCN2B, SCN4B, KCNQ1, SCN3B, KCNE2, NPPA, SCN1B
regulation of transporter activity (GO:0032409) 4.457SCN2B, SCN4B, KCNQ1, SCN3B, KCNE2, NPPA, SCN1B
response to chemical (GO:0042221) 1.987SCN2B, SCN5A, KCNQ1, KCNE2, NPPA, KCNA5, SCN1B
regulation of molecular function (GO:0065009) 1.787SCN2B, SCN4B, KCNQ1, SCN3B, KCNE2, NPPA, SCN1B
single-organism localization (GO:1902578) 2.097KCNA5, KCNQ1, KCNE2, KCNJ2, NUP155, SCN3B, ABCC9
muscle contraction (GO:0006936) 4.376SCN2B, SCN4B, KCNQ1, SCN3B, SCN5A, SCN1B
potassium ion transport (GO:0006813) 4.686KCNA5, KCNQ1, GJA5, KCNJ2, KCNE2, ABCC9
positive regulation of multicellular organismal process (GO:0051240) 2.496SCN5A, KCNQ1, SCN3B, GJA5, NPPA, SCN1B
anatomical structure development (GO:0048856) 1.586SCN2B, SCN5A, KCNQ1, SCN3B, KCNE2, GJA5
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) 6.846SCN5A, KCNQ1, GJA5, KCNE2, SCN4B, SCN1B
membrane depolarization (GO:0051899) 5.626SCN2B, SCN5A, SCN3B, KCNJ2, SCN4B, SCN1B
striated muscle contraction (GO:0006941) 5.376SCN2B, SCN4B, KCNQ1, SCN3B, SCN5A, SCN1B
single-organism transport (GO:0044765) 2.186KCNA5, KCNQ1, KCNE2, KCNJ2, NUP155, ABCC9
membrane depolarization during cardiac muscle cell action potential (GO:0086012) 7.096SCN2B, SCN4B, SCN3B, KCNJ2, SCN5A, SCN1B
negative regulation of biological process (GO:0048519) 1.336KCNA5, KCNQ1, GJA5, NUP155, KCNE2, NPPA
membrane depolarization during action potential (GO:0086010) 6.076SCN2B, SCN4B, SCN3B, KCNJ2, SCN5A, SCN1B
cardiac muscle contraction (GO:0060048) 5.886SCN2B, SCN5A, KCNQ1, SCN3B, SCN4B, SCN1B
regulation of homeostatic process (GO:0032844) 3.655SCN2B, SCN3B, SCN5A, GJA5, SCN1B
regulation of potassium ion transport (GO:0043266) 5.315KCNJ2, KCNQ1, KCNA5, NPPA, KCNE2
regulation of striated muscle contraction (GO:0006942) 5.385KCNJ2, KCNQ1, SCN5A, NPPA, GJA5
regulation of signaling (GO:0023051) 1.725ABCC9, GJA5, KCNA5, NPPA, KCNE2
cellular component organization or biogenesis (GO:0071840) 1.225KCNJ2, NUP155, KCNA5, GJA5, SCN3B
ventricular cardiac muscle cell action potential (GO:0086005) 7.025KCNQ1, SCN3B, SCN5A, GJA5, KCNE2
cellular response to stimulus (GO:0051716) 1.975KCNJ2, KCNQ1, SCN5A, NPPA, KCNE2
cellular potassium ion transport (GO:0071804) 4.795KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
potassium ion transmembrane transport (GO:0071805) 4.795KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
cellular component organization (GO:0016043) 1.245KCNJ2, NUP155, KCNA5, SCN3B, GJA5
sodium ion transmembrane transport (GO:0035725) 5.235SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
regulation of sodium ion transport (GO:0002028) 5.45SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
regulation of sodium ion transmembrane transport (GO:1902305) 5.865SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
regulation of muscle contraction (GO:0006937) 4.755KCNJ2, KCNQ1, SCN5A, GJA5, NPPA
sodium ion transport (GO:0006814) 4.755SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
single-organism developmental process (GO:0044767) 1.495KCNQ1, GJA5, SCN5A, NPPA, KCNE2
positive regulation of blood circulation (GO:1903524) 5.165KCNQ1, SCN3B, SCN5A, GJA5, NPPA
regulation of muscle system process (GO:0090257) 4.515KCNJ2, KCNQ1, SCN5A, GJA5, NPPA
regulation of postsynaptic membrane potential (GO:0060078) 5.725SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) 7.655SCN2B, SCN3B, SCN5A, GJA5, SCN1B
regulation of cardiac muscle contraction (GO:0055117) 5.575KCNJ2, KCNQ1, SCN5A, GJA5, NPPA
regulation of membrane depolarization (GO:0003254) 6.045SCN2B, SCN3B, SCN5A, GJA5, SCN1B
regulation of ion homeostasis (GO:2000021) 4.445SCN2B, SCN3B, SCN5A, GJA5, SCN1B
atrial cardiac muscle cell action potential (GO:0086014) 7.654KCNQ1, NUP155, KCNA5, SCN3B
response to external stimulus (GO:0009605) 2.554KCNJ2, ABCC9, KCNA5, NPPA
cell communication (GO:0007154) 3.044SCN2B, SCN5A, GJA5, SCN1B
positive regulation of cation transmembrane transport (GO:1904064) 5.174KCNJ2, KCNQ1, NPPA, KCNE2
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372) 7.944KCNQ1, SCN5A, KCNA5, NPPA
membrane repolarization (GO:0086009) 7.024KCNJ2, KCNQ1, KCNA5, KCNE2
regulation of potassium ion transmembrane transport (GO:1901379) 5.624KCNJ2, KCNQ1, NPPA, KCNE2
membrane repolarization during cardiac muscle cell action potential (GO:0086013) 7.434KCNJ2, KCNQ1, KCNA5, KCNE2
cardiac muscle cell membrane repolarization (GO:0099622) 7.434KCNJ2, KCNQ1, KCNA5, KCNE2
positive regulation of heart contraction (GO:0045823) 6.154KCNQ1, SCN5A, NPPA, SCN3B
positive regulation of heart rate (GO:0010460) 6.594SCN5A, KCNQ1, NPPA, SCN3B
regulation of sodium ion transmembrane transporter activity (GO:2000649) 6.094SCN2B, SCN4B, SCN3B, SCN1B
positive regulation of transmembrane transport (GO:0034764) 4.994KCNJ2, KCNQ1, NPPA, KCNE2
system development (GO:0048731) 2.924SCN2B, KCNQ1, SCN3B, GJA5
membrane repolarization during action potential (GO:0086011) 7.434KCNJ2, KCNQ1, KCNA5, KCNE2
positive regulation of ion transmembrane transport (GO:0034767) 5.054KCNJ2, KCNQ1, NPPA, KCNE2
positive regulation of sodium ion transport (GO:0010765) 6.234SCN5A, SCN4B, SCN3B, SCN1B
cellular component assembly (GO:0022607) 2.143KCNJ2, KCNA5, GJA5
regulation of secretion (GO:0051046) 3.23KCNQ1, KCNA5, GJA5
macromolecular complex subunit organization (GO:0043933) 2.143KCNJ2, KCNA5, GJA5
regulation of cardiac conduction (GO:1903779) 5.573ABCC9, GJA5, NPPA
regulation of response to stimulus (GO:0048583) 1.543NUP155, KCNQ1, KCNE2
negative regulation of potassium ion transport (GO:0043267) 6.263KCNQ1, KCNA5, KCNE2
cellular nitrogen compound metabolic process (GO:0034641) 1.223NUP155, KCNQ1, NPPA
circulatory system process (GO:0003013) 4.383KCNA5, NPPA, GJA5
signal transduction (GO:0007165) 1.283ABCC9, KCNA5, NPPA
cellular response to chemical stimulus (GO:0070887) 2.573KCNQ1, SCN5A, KCNE2
vascular process in circulatory system (GO:0003018) 4.653KCNA5, NPPA, GJA5
potassium ion import (GO:0010107) 6.43KCNJ2, ABCC9, KCNE2
regulation of cell communication (GO:0010646) 1.733KCNA5, GJA5, KCNE2
organic cyclic compound metabolic process (GO:1901360) 1.263NUP155, KCNQ1, NPPA
positive regulation of potassium ion transport (GO:0043268) 6.093KCNJ2, KCNQ1, NPPA
regulation of cardiac muscle cell contraction (GO:0086004) 6.513KCNJ2, SCN5A, GJA5
nucleobase-containing compound metabolic process (GO:0006139) 1.353NUP155, KCNQ1, NPPA
potassium ion export (GO:0071435) 7.433KCNQ1, KCNA5, KCNE2
regulation of blood vessel size (GO:0050880) 4.83KCNA5, NPPA, GJA5
regulation of metabolic process (GO:0019222) 1.023NUP155, KCNQ1, KCNE2
protein complex subunit organization (GO:0071822) 2.63KCNJ2, KCNA5, GJA5
response to mechanical stimulus (GO:0009612) 4.413KCNJ2, KCNA5, NPPA
regulation of anatomical structure size (GO:0090066) 3.783KCNA5, NPPA, GJA5
macromolecular complex assembly (GO:0065003) 2.553KCNJ2, KCNA5, GJA5
organic substance metabolic process (GO:0071704) 0.633NUP155, KCNQ1, NPPA
regulation of action potential (GO:0098900) 6.073KCNJ2, SCN5A, GJA5
heterocycle metabolic process (GO:0046483) 1.313NUP155, KCNQ1, NPPA
positive regulation of potassium ion transmembrane transport (GO:1901381) 6.433KCNJ2, KCNQ1, NPPA
regulation of tube size (GO:0035150) 4.793KCNA5, NPPA, GJA5
protein oligomerization (GO:0051259) 3.713KCNJ2, KCNA5, GJA5
regulation of actin filament-based process (GO:0032970) 3.973KCNJ2, SCN5A, GJA5
regulation of actin filament-based movement (GO:1903115) 6.333KCNJ2, SCN5A, GJA5
primary metabolic process (GO:0044238) 0.693NUP155, KCNQ1, NPPA
regulation of macromolecule metabolic process (GO:0060255) 1.083NUP155, KCNQ1, KCNE2
neurological system process (GO:0050877) 2.643KCNQ1, SCN3B, SCN1B
protein complex assembly (GO:0006461) 2.783KCNJ2, KCNA5, GJA5
cellular aromatic compound metabolic process (GO:0006725) 1.33NUP155, KCNQ1, NPPA
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373) 7.783SCN5A, SCN3B, GJA5
negative regulation of ion transport (GO:0043271) 4.943KCNQ1, KCNA5, KCNE2
response to stress (GO:0006950) 1.83ABCC9, KCNA5, NPPA
metabolic process (GO:0008152) 0.583NUP155, KCNQ1, NPPA
response to organic substance (GO:0010033) 2.23KCNQ1, KCNA5, NPPA
SA node cell action potential (GO:0086015) 7.943SCN5A, SCN3B, GJA5
multi-organism process (GO:0051704) 2.653ABCC9, NUP155, NPPA
response to oxygen-containing compound (GO:1901700) 2.573KCNQ1, KCNA5, NPPA
response to abiotic stimulus (GO:0009628) 2.83KCNJ2, KCNA5, NPPA
regulation of cellular component movement (GO:0051270) 3.083KCNJ2, SCN5A, GJA5
regulation of potassium ion transmembrane transporter activity (GO:1901016) 6.023KCNQ1, NPPA, KCNE2
cellular metabolic process (GO:0044237) 0.693NUP155, KCNQ1, NPPA
negative regulation of transport (GO:0051051) 3.63KCNQ1, KCNA5, KCNE2
nitrogen compound metabolic process (GO:0006807) 1.133NUP155, KCNQ1, NPPA
regulation of delayed rectifier potassium channel activity (GO:1902259) 6.843KCNQ1, NPPA, KCNE2
regulation of cation channel activity (GO:2001257) 5.273KCNQ1, NPPA, KCNE2
negative regulation of cellular process (GO:0048523) 1.413KCNQ1, NPPA, KCNE2
protein localization (GO:0008104) 2.362NUP155, SCN3B
response to toxic substance (GO:0009636) 4.882SCN2B, SCN1B
regulation of vasoconstriction (GO:0019229) 5.512KCNA5, GJA5
membrane organization (GO:0061024) 3.042NUP155, SCN3B
potassium ion homeostasis (GO:0055075) 6.842KCNJ2, KCNA5
positive regulation of striated muscle contraction (GO:0045989) 6.962KCNQ1, NPPA
cell surface receptor signaling pathway (GO:0007166) 2.092KCNA5, NPPA
membrane depolarization during Purkinje myocyte cell action potential (GO:0086047) 9.042SCN5A, SCN1B
inorganic ion homeostasis (GO:0098771) 3.432KCNJ2, KCNA5
negative regulation of ion transmembrane transport (GO:0034766) 5.472KCNQ1, KCNE2
organic cyclic compound biosynthetic process (GO:1901362) 1.662NUP155, NPPA
negative regulation of transmembrane transport (GO:0034763) 5.382KCNQ1, KCNE2
negative regulation of macromolecule metabolic process (GO:0010605) 2.012NUP155, KCNQ1
cellular macromolecule localization (GO:0070727) 3.12NUP155, SCN3B
interspecies interaction between organisms (GO:0044419) 3.082ABCC9, NUP155
gene silencing (GO:0016458) 4.62NUP155, KCNQ1
animal organ development (GO:0048513) 2.532GJA5, KCNE2
positive regulation of molecular function (GO:0044093) 2.232NPPA, KCNE2
negative regulation of molecular function (GO:0044092) 2.742KCNQ1, KCNE2
macromolecule localization (GO:0033036) 2.342NUP155, SCN3B
regulation of cell proliferation (GO:0042127) 2.412SCN5A, KCNA5
sensory perception (GO:0007600) 2.932KCNQ1, SCN3B
protein localization to membrane (GO:0072657) 3.952NUP155, SCN3B
negative regulation of voltage-gated potassium channel activity (GO:1903817) 7.532KCNQ1, KCNE2
response to inorganic substance (GO:0010035) 3.562SCN5A, KCNA5
protein metabolic process (GO:0019538) 1.452NUP155, NPPA
response to organonitrogen compound (GO:0010243) 3.22KCNQ1, NPPA
chemical homeostasis (GO:0048878) 2.972KCNJ2, KCNA5
membrane repolarization during ventricular cardiac muscle cell action potential (GO:0098915) 8.342KCNQ1, KCNE2
anterograde trans-synaptic signaling (GO:0098916) 3.982SCN2B, SCN1B
renal system process (GO:0003014) 5.172KCNQ1, GJA5
positive regulation of ion transmembrane transporter activity (GO:0032414) 5.552NPPA, KCNE2
negative regulation of metabolic process (GO:0009892) 1.932NUP155, KCNQ1
positive regulation of transporter activity (GO:0032411) 5.442NPPA, KCNE2
negative regulation of ion transmembrane transporter activity (GO:0032413) 5.742KCNQ1, KCNE2
cellular response to mechanical stimulus (GO:0071260) 5.332KCNJ2, NPPA
negative regulation of gene expression (GO:0010629) 2.482NUP155, KCNQ1
regulation of protein transport (GO:0051223) 3.122KCNA5, GJA5
cellular protein metabolic process (GO:0044267) 1.632NUP155, NPPA
response to hypoxia (GO:0001666) 4.132KCNA5, NPPA
regulation of protein secretion (GO:0050708) 3.772KCNA5, GJA5
cellular macromolecule metabolic process (GO:0044260) 0.932NUP155, NPPA
cellular response to abiotic stimulus (GO:0071214) 4.152KCNJ2, NPPA
heterocycle biosynthetic process (GO:0018130) 1.72NUP155, NPPA
regulation of establishment of protein localization (GO:0070201) 3.022KCNA5, GJA5
single-organism membrane organization (GO:0044802) 3.192NUP155, SCN3B
aromatic compound biosynthetic process (GO:0019438) 1.72NUP155, NPPA
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722NUP155, NPPA
RNA metabolic process (GO:0016070) 1.592NUP155, NPPA
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592NUP155, NPPA
response to decreased oxygen levels (GO:0036293) 4.092KCNA5, NPPA
regulation of response to stress (GO:0080134) 2.532NUP155, KCNQ1
macromolecule biosynthetic process (GO:0009059) 1.612NUP155, NPPA
ventricular cardiac muscle cell membrane repolarization (GO:0099625) 8.342KCNQ1, KCNE2
negative regulation of cation channel activity (GO:2001258) 6.262KCNQ1, KCNE2
response to insecticide (GO:0017085) 7.332SCN2B, SCN1B
synaptic signaling (GO:0099536) 3.982SCN2B, SCN1B
trans-synaptic signaling (GO:0099537) 3.982SCN2B, SCN1B
RNA biosynthetic process (GO:0032774) 1.842NUP155, NPPA
ion homeostasis (GO:0050801) 3.422KCNJ2, KCNA5
chemical synaptic transmission (GO:0007268) 3.982SCN2B, SCN1B
regulation of cellular component organization (GO:0051128) 2.012NPPA, SCN1B
cellular biosynthetic process (GO:0044249) 1.372NUP155, NPPA
regulation of secretion by cell (GO:1903530) 3.282KCNA5, GJA5
negative regulation of transporter activity (GO:0032410) 5.592KCNQ1, KCNE2
anatomical structure morphogenesis (GO:0009653) 2.532SCN5A, GJA5
regulation of protein localization (GO:0032880) 2.882KCNA5, GJA5
response to endogenous stimulus (GO:0009719) 2.792KCNQ1, NPPA
negative regulation of multicellular organismal process (GO:0051241) 2.842NPPA, GJA5
response to oxygen levels (GO:0070482) 4.022KCNA5, NPPA
positive regulation of cell proliferation (GO:0008284) 3.012SCN5A, KCNA5
cellular response to external stimulus (GO:0071496) 4.22KCNJ2, NPPA
negative regulation of delayed rectifier potassium channel activity (GO:1902260) 7.532KCNQ1, KCNE2
cellular metal ion homeostasis (GO:0006875) 3.752KCNJ2, KCNA5
cellular ion homeostasis (GO:0006873) 3.572KCNJ2, KCNA5
cellular cation homeostasis (GO:0030003) 3.62KCNJ2, KCNA5
cation homeostasis (GO:0055080) 3.462KCNJ2, KCNA5
cellular chemical homeostasis (GO:0055082) 3.42KCNJ2, KCNA5
AV node cell action potential (GO:0086016) 8.342SCN5A, SCN4B
nucleic acid metabolic process (GO:0090304) 1.462NUP155, NPPA
response to drug (GO:0042493) 3.712KCNQ1, KCNE2
negative regulation of cation transmembrane transport (GO:1904063) 5.652KCNQ1, KCNE2
macromolecule metabolic process (GO:0043170) 0.832NUP155, NPPA
positive regulation of cardiac muscle contraction (GO:0060452) 7.242KCNQ1, NPPA
response to nitrogen compound (GO:1901698) 3.122KCNQ1, NPPA
positive regulation of cation channel activity (GO:2001259) 6.172NPPA, KCNE2
cellular homeostasis (GO:0019725) 3.232KCNJ2, KCNA5
regulation of calcium ion transmembrane transport (GO:1903169) 4.982NPPA, KCNE2
homeostatic process (GO:0042592) 2.612KCNJ2, KCNA5
cellular response to drug (GO:0035690) 5.482KCNQ1, KCNE2
regulation of blood pressure (GO:0008217) 4.722NPPA, GJA5
AV node cell to bundle of His cell communication (GO:0086067) 8.342SCN5A, GJA5
cell communication involved in cardiac conduction (GO:0086065) 6.732SCN5A, GJA5
protein homooligomerization (GO:0051260) 4.212KCNJ2, KCNA5
regulation of voltage-gated calcium channel activity (GO:1901385) 6.592NPPA, KCNE2
response to pyrethroid (GO:0046684) 8.122SCN2B, SCN1B
negative regulation of potassium ion transmembrane transport (GO:1901380) 6.682KCNQ1, KCNE2
regulation of gene expression (GO:0010468) 1.372NUP155, KCNQ1
positive regulation of muscle contraction (GO:0045933) 5.92KCNQ1, NPPA
organic substance biosynthetic process (GO:1901576) 1.342NUP155, NPPA
cellular protein localization (GO:0034613) 3.112NUP155, SCN3B
biosynthetic process (GO:0009058) 1.322NUP155, NPPA
multi-organism cellular process (GO:0044764) 3.142ABCC9, NUP155
monovalent inorganic cation homeostasis (GO:0055067) 4.932KCNJ2, KCNA5
metal ion homeostasis (GO:0055065) 3.612KCNJ2, KCNA5
cell-cell signaling (GO:0007267) 3.352SCN2B, SCN1B
cellular localization (GO:0051641) 2.322NUP155, SCN3B
regulation of calcium ion transmembrane transporter activity (GO:1901019) 5.492NPPA, KCNE2
nervous system development (GO:0007399) 3.532SCN2B, SCN3B
negative regulation of blood pressure (GO:0045776) 5.992NPPA, GJA5
regulation of calcium ion transport (GO:0051924) 4.382NPPA, KCNE2
negative regulation of potassium ion transmembrane transporter activity (GO:1901017) 6.962KCNQ1, KCNE2
viral process (GO:0016032) 3.152ABCC9, NUP155
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152ABCC9, NUP155
single-organism cellular localization (GO:1902580) 3.162NUP155, SCN3B

NET-GE enrichment

Term New enriched termICP valueGenes
protein localization (GO:0008104) -2.360.024SCN5A, KCNQ1, SCN3B, KCNE2, NPPA, KCNA5, SCN1B
regulation of transport (GO:0051049) -2.240.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, NUP155, SCN3B, KCNA5, SCN1B
regulation of homeostatic process (GO:0032844) -3.650.001SCN2B, SCN3B, SCN5A, GJA5, SCN1B
potassium ion import (GO:0010107) -6.40.0KCNJ2, ABCC9, KCNA5, KCNE2
membrane depolarization (GO:0051899) -5.620.0SCN2B, SCN5A, SCN3B, KCNJ2, SCN4B, SCN1B
potassium ion homeostasis (GO:0055075) -6.840.026KCNJ2, KCNA5
positive regulation of transmembrane transport (GO:0034764) -4.990.039KCNJ2, KCNQ1, KCNA5
regulation of ion transmembrane transport (GO:0034765) -3.770.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, NPPA, SCN4B, SCN1B
positive regulation of ion transmembrane transport (GO:0034767) -5.050.031KCNJ2, KCNQ1, KCNA5
regulation of transmembrane transport (GO:0034762) -3.740.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, KCNA5, SCN1B
potassium ion export (GO:0071435) -7.430.0KCNQ1, KCNA5, KCNE2
regulation of localization (GO:0032879) -1.940.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, NUP155, SCN3B, KCNA5, SCN1B
cellular macromolecule localization (GO:0070727) -3.10.004SCN5A, KCNQ1, SCN3B, KCNE2, NPPA, KCNA5, SCN1B
macromolecule localization (GO:0033036) -2.340.026SCN5A, KCNQ1, SCN3B, KCNE2, NPPA, KCNA5, SCN1B
regulation of sodium ion transmembrane transport (GO:1902305) -5.860.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
muscle contraction (GO:0006936) -4.370.0SCN2B, SCN4B, KCNQ1, SCN3B, NPPA, SCN5A, SCN1B
regulation of muscle contraction (GO:0006937) -4.750.037KCNJ2, SCN5A, KCNA5, NPPA, GJA5
sensory perception of sound (GO:0007605) NEW4.820.011KCNQ1, KCNA5, SCN5A, GJA5, SCN1B
regulation of sodium ion transmembrane transporter activity (GO:2000649) -6.090.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
sensory perception (GO:0007600) -2.930.048SCN5A, KCNQ1, SCN3B, GJA5, NPPA, KCNA5, SCN1B
regulation of potassium ion transmembrane transport (GO:1901379) -5.620.0KCNJ2, KCNQ1, KCNA5, KCNE2
system process (GO:0003008) -2.30.0SCN2B, SCN4B, KCNQ1, SCN3B, KCNJ2, NPPA, SCN5A, SCN1B
single organism signaling (GO:0044700) -3.250.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, KCNA5, SCN4B, SCN1B
single-multicellular organism process (GO:0044707) -1.780.002SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, KCNA5, SCN4B, SCN1B
muscle system process (GO:0003012) -4.180.0SCN2B, SCN5A, KCNQ1, GJA5, KCNJ2, SCN3B, NPPA, KCNA5, SCN4B, SCN1B
positive regulation of heart contraction (GO:0045823) -6.150.007SCN5A, NPPA, SCN3B
regulation of delayed rectifier potassium channel activity (GO:1902259) -6.840.024KCNQ1, KCNE2
regulation of membrane potential (GO:0042391) -3.890.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, SCN4B, SCN1B
regulation of ion transmembrane transporter activity (GO:0032412) -4.550.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, SCN3B, NPPA, KCNA5, SCN1B
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) -6.840.0SCN5A, KCNQ1, KCNE2, KCNA5, SCN4B, SCN1B
regulation of membrane repolarization (GO:0060306) -6.40.0SCN5A, KCNQ1, KCNE2, KCNJ2, KCNA5, SCN4B, SCN1B
action potential (GO:0001508) -5.420.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, SCN4B, SCN1B
inorganic cation transmembrane transport (GO:0098662) -3.550.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, ABCC9, SCN4B, SCN1B
inorganic ion transmembrane transport (GO:0098660) -3.380.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, ABCC9, KCNA5, SCN4B, SCN1B
regulation of biological quality (GO:0065008) -1.680.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, SCN4B, SCN1B
regulation of heart contraction (GO:0008016) -4.350.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, KCNA5, SCN4B, SCN1B
potassium ion transport (GO:0006813) -4.680.002KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
cation transport (GO:0006812) -3.110.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
ion transport (GO:0006811) -2.660.0SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, KCNA5, SCN1B
transport (GO:0006810) -1.510.0SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, SCN4B, SCN1B
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372) -7.940.0KCNQ1, KCNA5, SCN5A
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373) -7.780.004SCN5A, SCN3B
sodium ion transport (GO:0006814) -4.750.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
regulation of multicellular organismal process (GO:0051239) -1.870.0SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, SCN4B, SCN1B
establishment of localization (GO:0051234) -1.480.0SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, KCNA5, SCN1B
regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) -7.650.0SCN2B, SCN3B, SCN5A, GJA5, SCN1B
cardiac muscle cell action potential involved in contraction (GO:0086002) -6.470.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, KCNA5, SCN4B, SCN1B
regulation of transmembrane transporter activity (GO:0022898) -4.520.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, SCN3B, NPPA, KCNA5, SCN1B
regulation of inward rectifier potassium channel activity (GO:1901979) NEW9.040.003KCNQ1, KCNE2
response to insecticide (GO:0017085) -7.330.011SCN2B, SCN5A, SCN1B
regulation of muscle system process (GO:0090257) -4.510.007KCNJ2, SCN5A, KCNA5, NPPA, GJA5
multicellular organismal signaling (GO:0035637) -5.360.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, SCN4B, SCN1B
striated muscle contraction (GO:0006941) -5.370.0SCN2B, SCN4B, KCNQ1, SCN3B, NPPA, SCN5A, SCN1B
regulation of striated muscle contraction (GO:0006942) -5.380.004KCNJ2, SCN5A, GJA5
signaling (GO:0023052) -3.250.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
cardiac muscle contraction (GO:0060048) -5.880.0SCN2B, SCN4B, KCNQ1, SCN3B, SCN5A, SCN1B
ventricular cardiac muscle cell action potential (GO:0086005) -7.020.0KCNA5, SCN5A, KCNQ1, SCN3B, KCNE2
cardiac muscle cell action potential (GO:0086001) -6.330.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, SCN4B, SCN1B
cellular potassium ion transport (GO:0071804) -4.790.0KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
potassium ion transmembrane transport (GO:0071805) -4.790.0KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
membrane repolarization (GO:0086009) -7.020.0KCNJ2, KCNQ1, KCNA5, KCNE2
SA node cell to atrial cardiac muscle cell communication (GO:0086070) NEW9.040.003SCN5A, SCN3B
regulation of heart rate (GO:0002027) -5.290.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, NPPA, SCN4B, SCN1B
regulation of transporter activity (GO:0032409) -4.450.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, SCN3B, NPPA, SCN4B, SCN1B
sensory perception of mechanical stimulus (GO:0050954) NEW4.790.014KCNQ1, SCN5A, KCNA5, GJA5, SCN1B
monovalent inorganic cation transport (GO:0015672) -3.740.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, ABCC9, SCN4B, SCN1B
regulation of sodium ion transport (GO:0002028) -5.40.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
positive regulation of sodium ion transport (GO:0010765) -6.230.0SCN5A, SCN4B, SCN3B, SCN1B
multicellular organismal process (GO:0032501) -1.450.002SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, KCNA5, SCN1B
positive regulation of ion transport (GO:0043270) -4.360.0SCN5A, KCNQ1, SCN3B, KCNA5, KCNJ2, NPPA, SCN4B, SCN1B
regulation of system process (GO:0044057) -3.530.0SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, SCN4B, SCN1B
metal ion transport (GO:0030001) -3.360.0SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
membrane repolarization during cardiac muscle cell action potential (GO:0086013) -7.430.009KCNJ2, KCNQ1, KCNA5
membrane depolarization during cardiac muscle cell action potential (GO:0086012) -7.090.0SCN2B, SCN4B, SCN3B, KCNJ2, SCN5A, SCN1B
membrane repolarization during action potential (GO:0086011) -7.430.0KCNJ2, KCNQ1, KCNA5, KCNE2
membrane depolarization during action potential (GO:0086010) -6.070.0SCN2B, SCN4B, SCN3B, KCNJ2, SCN5A, SCN1B
transmembrane transport (GO:0055085) -2.720.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
atrial cardiac muscle cell action potential (GO:0086014) -7.650.0SCN5A, KCNQ1, SCN3B, NUP155, GJA5, KCNA5
regulation of membrane depolarization (GO:0003254) -6.040.0SCN2B, KCNA5, SCN3B, GJA5, SCN5A, SCN1B
regulation of heart rate by cardiac conduction (GO:0086091) -6.330.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, KCNA5, SCN1B
regulation of potassium ion transport (GO:0043266) -5.310.002KCNJ2, KCNQ1, KCNA5, KCNE2
bundle of His cell to Purkinje myocyte communication (GO:0086069) NEW9.040.042SCN5A, GJA5
AV node cell to bundle of His cell communication (GO:0086067) -8.340.0SCN5A, SCN4B, GJA5
cell communication involved in cardiac conduction (GO:0086065) -6.730.0SCN5A, SCN4B, SCN3B, GJA5
regulation of ion transport (GO:0043269) -3.40.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, KCNA5, SCN1B
positive regulation of potassium ion transport (GO:0043268) -6.090.003KCNJ2, KCNQ1, KCNA5
positive regulation of transport (GO:0051050) -2.90.001SCN4B, KCNQ1, SCN3B, KCNJ2, SCN5A, SCN1B
sodium ion transmembrane transport (GO:0035725) -5.230.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
positive regulation of heart rate (GO:0010460) -6.590.003SCN5A, NPPA, SCN3B
response to pyrethroid (GO:0046684) -8.120.002SCN2B, SCN5A, SCN1B
positive regulation of potassium ion transmembrane transport (GO:1901381) -6.430.014KCNJ2, KCNQ1, KCNA5
cardiac conduction (GO:0061337) -5.540.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, KCNA5, SCN4B, SCN1B
cellular protein localization (GO:0034613) -3.110.003SCN5A, KCNQ1, SCN3B, KCNE2, NPPA, KCNA5, SCN1B
regulation of metal ion transport (GO:0010959) -3.940.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNA5, KCNJ2, SCN3B, NPPA, SCN4B, SCN1B
ion transmembrane transport (GO:0034220) -3.080.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
single-organism transport (GO:0044765) -2.180.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, ABCC9, SCN4B, SCN1B
monovalent inorganic cation homeostasis (GO:0055067) -4.930.02KCNJ2, KCNA5, SCN5A, NPPA
synaptic transmission (GO:0007268) -3.980.0SCN2B, SCN5A, KCNQ1, KCNJ2, NPPA, ABCC9, KCNA5, SCN1B
cell-cell signaling (GO:0007267) -3.350.002SCN2B, SCN5A, KCNQ1, GJA5, KCNJ2, NPPA, ABCC9, KCNA5, SCN1B
cell communication (GO:0007154) -3.040.0SCN2B, SCN5A, SCN4B, KCNQ1, GJA5, KCNJ2, SCN3B, NPPA, ABCC9, KCNA5, SCN1B
localization (GO:0051179) -1.40.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, KCNA5, SCN4B, SCN1B
cellular localization (GO:0051641) -2.320.012SCN5A, KCNQ1, SCN3B, KCNE2, NPPA, KCNA5, SCN1B
regulation of potassium ion transmembrane transporter activity (GO:1901016) -6.020.007KCNQ1, KCNA5, KCNE2
regulation of ion homeostasis (GO:2000021) -4.440.0SCN2B, SCN5A, SCN3B, GJA5, NPPA, SCN1B
cation transmembrane transport (GO:0098655) -3.430.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1113SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
protein complex (GO:0043234) 1.5112SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, KCNA5, SCN1B
membrane (GO:0016020) 0.6812SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, NUP155, KCNE2, ABCC9, SCN4B, SCN1B
macromolecular complex (GO:0032991) 1.3512SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, KCNA5, SCN1B
integral component of membrane (GO:0016021) 1.1411SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
plasma membrane protein complex (GO:0098797) 3.5511SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
membrane protein complex (GO:0098796) 2.8411SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
membrane part (GO:0044425) 0.9511SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
plasma membrane part (GO:0044459) 1.9511SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, ABCC9, SCN4B, SCN1B
intrinsic component of membrane (GO:0031224) 1.1311SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, KCNA5, SCN4B, SCN1B
transmembrane transporter complex (GO:1902495) 4.0610SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
transporter complex (GO:1990351) 4.0410SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
ion channel complex (GO:0034702) 4.1810SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
cation channel complex (GO:0034703) 4.6910SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
plasma membrane (GO:0005886) 1.3910SCN5A, KCNQ1, SCN3B, GJA5, KCNJ2, KCNE2, ABCC9, KCNA5, SCN4B, SCN1B
intracellular part (GO:0044424) 0.289KCNA5, KCNQ1, KCNE2, KCNJ2, NUP155, SCN3B, NPPA, ABCC9, SCN5A
cytoplasmic part (GO:0044444) 0.828SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, NPPA, ABCC9, KCNA5
intracellular organelle (GO:0043229) 0.517SCN5A, KCNQ1, KCNE2, KCNJ2, NUP155, NPPA, KCNA5
membrane-bounded organelle (GO:0043227) 0.477SCN5A, KCNQ1, KCNE2, KCNJ2, NUP155, NPPA, KCNA5
intracellular membrane-bounded organelle (GO:0043231) 0.67SCN5A, KCNQ1, KCNE2, KCNJ2, NUP155, NPPA, KCNA5
organelle (GO:0043226) 0.47SCN5A, KCNQ1, KCNE2, KCNJ2, NUP155, NPPA, KCNA5
intercalated disc (GO:0014704) 5.936SCN5A, GJA5, KCNA5, KCNJ2, SCN4B, SCN1B
cell-cell contact zone (GO:0044291) 5.696SCN5A, GJA5, KCNA5, KCNJ2, SCN4B, SCN1B
cell-cell junction (GO:0005911) 3.856SCN5A, GJA5, KCNA5, KCNJ2, SCN4B, SCN1B
organelle part (GO:0044422) 0.796SCN5A, KCNQ1, SCN3B, NUP155, ABCC9, KCNA5
cell junction (GO:0030054) 2.756SCN5A, GJA5, KCNA5, KCNJ2, SCN4B, SCN1B
sodium channel complex (GO:0034706) 6.975SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
potassium channel complex (GO:0034705) 5.325KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
voltage-gated potassium channel complex (GO:0008076) 5.345KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
voltage-gated sodium channel complex (GO:0001518) 7.165SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
intrinsic component of plasma membrane (GO:0031226) 2.534KCNJ2, KCNA5, SCN4B, GJA5
endoplasmic reticulum (GO:0005783) 2.564KCNJ2, KCNQ1, SCN5A, KCNA5
contractile fiber part (GO:0044449) 4.534ABCC9, SCN5A, KCNA5, SCN3B
plasma membrane region (GO:0098590) 2.973KCNQ1, SCN5A, KCNA5
membrane raft (GO:0045121) 4.183KCNQ1, SCN5A, KCNA5
lytic vacuole (GO:0000323) 3.893KCNQ1, NPPA, KCNE2
vacuole (GO:0005773) 2.923KCNQ1, NPPA, KCNE2
membrane region (GO:0098589) 3.953KCNQ1, SCN5A, KCNA5
lysosome (GO:0005764) 3.893KCNQ1, NPPA, KCNE2
T-tubule (GO:0030315) 6.093KCNJ2, SCN5A, SCN1B
integral component of plasma membrane (GO:0005887) 2.573KCNJ2, KCNA5, GJA5
membrane microdomain (GO:0098857) 4.173KCNQ1, SCN5A, KCNA5
Z disc (GO:0030018) 5.113SCN5A, KCNA5, SCN3B
cytoplasm (GO:0005737) 1.012KCNQ1, NPPA
Golgi apparatus (GO:0005794) 2.72KCNJ2, KCNA5
sarcolemma (GO:0042383) 5.22ABCC9, SCN5A
organelle membrane (GO:0031090) 1.972NUP155, KCNQ1
neuron part (GO:0097458) 2.642KCNJ2, SCN1B
nucleus (GO:0005634) 1.072NUP155, NPPA
cell projection part (GO:0044463) 2.972KCNJ2, SCN1B
intracellular organelle part (GO:0044446) 0.812NUP155, KCNQ1
caveola (GO:0005901) 5.552SCN5A, KCNA5
extracellular region (GO:0005576) 2.182NPPA, SCN1B
plasma membrane raft (GO:0044853) 5.422SCN5A, KCNA5
cell projection (GO:0042995) 2.472KCNJ2, GJA5
cell surface (GO:0009986) 3.442SCN5A, KCNE2
perinuclear region of cytoplasm (GO:0048471) 3.352KCNA5, NPPA

NET-GE enrichment

Term New enriched termICP valueGenes
lytic vacuole (GO:0000323) -3.890.036KCNQ1, NPPA, KCNE2
sodium channel complex (GO:0034706) -6.970.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
potassium channel complex (GO:0034705) -5.320.0KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
ion channel complex (GO:0034702) -4.180.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
cation channel complex (GO:0034703) -4.690.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
transmembrane transporter complex (GO:1902495) -4.060.0SCN2B, SCN5A, SCN4B, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN1B
intrinsic component of membrane (GO:0031224) -1.130.035KCNJ2, SCN5A, SCN4B
Z disc (GO:0030018) -5.110.006KCNQ1, SCN5A, KCNA5, SCN3B
cell junction (GO:0030054) -2.750.003SCN5A, GJA5, KCNA5, KCNJ2, SCN4B, SCN1B
neuromuscular junction (GO:0031594) NEW5.810.018KCNQ1, SCN5A, KCNA5
plasma membrane part (GO:0044459) -1.950.0SCN2B, SCN5A, KCNQ1, SCN3B, GJA5, KCNA5, KCNJ2, KCNE2, NPPA, ABCC9, SCN4B, SCN1B
sarcolemma (GO:0042383) -5.20.001ABCC9, SCN5A, KCNA5, KCNQ1
T-tubule (GO:0030315) -6.090.006KCNJ2, SCN5A, SCN1B
transporter complex (GO:1990351) -4.040.0SCN2B, SCN5A, KCNQ1, KCNE2, KCNJ2, SCN3B, ABCC9, KCNA5, SCN4B, SCN1B
cell-cell contact zone (GO:0044291) -5.690.0SCN5A, GJA5, KCNA5, KCNJ2, SCN4B, SCN1B
cell body (GO:0044297) NEW3.740.008SCN5A, KCNQ1, KCNJ2, NPPA, KCNA5, SCN1B
voltage-gated potassium channel complex (GO:0008076) -5.340.0KCNJ2, ABCC9, KCNA5, KCNE2, KCNQ1
cell-cell junction (GO:0005911) -3.850.0SCN5A, GJA5, KCNA5, KCNJ2, NPPA, SCN4B, SCN1B
voltage-gated sodium channel complex (GO:0001518) -7.160.0SCN2B, SCN5A, SCN4B, SCN3B, SCN1B
protein complex (GO:0043234) -1.510.0SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, KCNA5, SCN1B
intercalated disc (GO:0014704) -5.930.0SCN5A, GJA5, KCNA5, KCNJ2, SCN4B, SCN1B
macromolecular complex (GO:0032991) -1.350.0SCN2B, SCN5A, SCN4B, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, NPPA, ABCC9, KCNA5, SCN1B
neuronal cell body (GO:0043025) NEW3.90.004SCN5A, KCNQ1, KCNJ2, NPPA, KCNA5, SCN1B
lysosome (GO:0005764) -3.890.036KCNQ1, NPPA, KCNE2
membrane part (GO:0044425) -0.950.003SCN2B, SCN5A, KCNA5, KCNQ1, SCN3B, GJA5, KCNJ2, NUP155, KCNE2, ABCC9, SCN4B, SCN1B
contractile fiber part (GO:0044449) -4.530.023SCN5A, KCNQ1, SCN3B, NPPA, ABCC9, KCNA5