Disease table of BRUGADA SYNDROME OMIM ID: PS601144

Gene-disease associations table

Gene	Associated with BRUGADA SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
KCNE3	ClinVar, OMIM	HGNC link	11q13.4	2	PS601144, 115000
KCND3	ClinVar, OMIM, HUMSAVAR	HGNC link	1p13.2	2	PS601144, PS164400
CACNB2	ClinVar, OMIM, HUMSAVAR	HGNC link	10p12.33	2	PS601144, 115000
CACNA1C	ClinVar, OMIM, HUMSAVAR	HGNC link	12p13.33	4	PS601144, 603829, 115000, PS192500
HCN4	ClinVar, OMIM	HGNC link	15q24.1	3	PS601144, PS608567, 115000
SCN1B	ClinVar, OMIM	HGNC link	19q13.11	4	PS601144, PS608583, 115000, PS604233
GPD1L	ClinVar, OMIM, HUMSAVAR	HGNC link	3p22.3	2	272120, PS601144
SCN5A	ClinVar, OMIM, HUMSAVAR	HGNC link	3p22.2	11	272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567
SCN3B	ClinVar, OMIM, HUMSAVAR	HGNC link	11q24.1	2	PS601144, PS608583

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
3p22	2	SCN5A, GPD1L

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
3p2	2	SCN5A, GPD1L

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3p	2	SCN5A, GPD1L
11q	2	KCNE3, SCN3B

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	KCNE3, SCN3B
3	2	SCN5A, GPD1L

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
HCN4	YES	1	SP1	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
KCNE3	GPD1L	No	1	GAPDH
CACNA1C	SCN5A	No	1	CALM1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
KCNE3	KCND3	Yes	binding	0
KCND3	HCN4	No	-	1	SRC
CACNB2	SCN1B	No	-	8	PRKX, CAMK2A, CAMK2B, PRKACG, PRKACB, CAMK2D, PRKACA, CAMK2G
SCN1B	SCN3B	Yes	binding	8	SCN2B, SCN10A, SCNN1A, SCN3A, SCN2A, SCN8A, SCNN1G, SCNN1B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CACNA1C	SCN5A	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	4	CACNA1C, CACNB2, SCN5A, SCN1B
Cardiac muscle contraction	hsa04260	6.34	2	CACNA1C, CACNB2
cAMP signaling pathway	hsa04024	5.05	2	CACNA1C, HCN4
MAPK signaling pathway	hsa04010	4.63	2	CACNA1C, CACNB2
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	2	CACNA1C, CACNB2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32	2	CACNA1C, CACNB2
Dilated cardiomyopathy	hsa05414	6.08	2	CACNA1C, CACNB2
Oxytocin signaling pathway	hsa04921	5.4	2	CACNA1C, CACNB2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Circulatory system	NEW	4.63	0.003	GPD1L, CACNA1C, CACNB2, SCN5A, SCN1B
Adrenergic signaling in cardiomyocytes (hsa04261)	-	5.44	0.0	CACNA1C, CACNB2, SCN5A, SCN1B

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Axon guidance	R-HSA-422475	3.93	5	CACNA1C, CACNB2, SCN5A, SCN3B, SCN1B
Developmental Biology	R-HSA-1266738	3.48	5	CACNA1C, CACNB2, SCN5A, SCN3B, SCN1B
Neuronal System	R-HSA-112316	4.82	3	CACNB2, KCND3, HCN4
L1CAM interactions	R-HSA-373760	6.19	3	SCN5A, SCN3B, SCN1B
Interaction between L1 and Ankyrins	R-HSA-445095	8.03	3	SCN5A, SCN3B, SCN1B
Metabolism	R-HSA-1430728	2.34	3	GPD1L, CACNA1C, CACNB2
Regulation of insulin secretion	R-HSA-422356	6.66	2	CACNA1C, CACNB2
Potassium Channels	R-HSA-1296071	6.35	2	KCND3, HCN4
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.18	2	CACNA1C, CACNB2
Integration of energy metabolism	R-HSA-163685	6.24	2	CACNA1C, CACNB2
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	CACNA1C, CACNB2
NCAM1 interactions	R-HSA-419037	7.59	2	CACNA1C, CACNB2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
L1CAM interactions (R-HSA-373760)	-	6.19	0.003	SCN5A, SCN3B, SCN1B
Potassium Channels (R-HSA-1296071)	-	6.35	0.032	CACNA1C, KCND3, HCN4
Adrenaline,noradrenaline inhibits insulin secretion (R-HSA-400042)	-	8.18	0.007	CACNA1C, CACNB2
Interaction between L1 and Ankyrins (R-HSA-445095)	-	8.03	0.0	SCN5A, SCN3B, SCN1B
NCAM1 interactions (R-HSA-419037)	-	7.59	0.017	CACNA1C, CACNB2
Neuronal System (R-HSA-112316)	-	4.82	0.05	CACNB2, KCND3, HCN4
Axon guidance (R-HSA-422475)	-	3.93	0.01	CACNA1C, GPD1L, SCN5A, SCN3B, CACNB2, SCN1B
Developmental Biology (R-HSA-1266738)	-	3.48	0.006	CACNA1C, CACNB2, SCN5A, SCN3B, SCN1B

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
substrate-specific transporter activity (GO:0022892)	2.72	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cation channel activity (GO:0005261)	4.04	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
substrate-specific channel activity (GO:0022838)	3.67	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
transporter activity (GO:0005215)	2.57	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion channel activity (GO:0005216)	3.71	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cation transmembrane transporter activity (GO:0008324)	3.32	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion transmembrane transporter activity (GO:0015075)	3.04	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
voltage-gated channel activity (GO:0022832)	4.49	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
transmembrane transporter activity (GO:0022857)	2.82	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
channel activity (GO:0015267)	3.6	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
binding (GO:0005488)	0.18	8	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3
protein binding (GO:0005515)	0.46	8	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3
passive transmembrane transporter activity (GO:0022803)	3.6	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
metal ion transmembrane transporter activity (GO:0046873)	3.71	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
voltage-gated ion channel activity (GO:0005244)	4.49	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
gated channel activity (GO:0022836)	3.96	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	6	SCN5A, HCN4, KCNE3, SCN3B, KCND3, SCN1B
channel regulator activity (GO:0016247)	4.88	5	GPD1L, CACNB2, KCNE3, SCN3B, SCN1B
ion channel binding (GO:0044325)	5.02	5	GPD1L, KCNE3, KCND3, SCN5A, SCN3B
molecular function regulator (GO:0098772)	2.51	5	GPD1L, CACNB2, KCNE3, SCN3B, SCN1B
voltage-gated cation channel activity (GO:0022843)	4.83	5	CACNA1C, CACNB2, KCNE3, KCND3, HCN4
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030)	6.74	4	SCN3B, SCN5A, HCN4, SCN1B
sodium channel activity (GO:0005272)	6.13	4	SCN3B, SCN5A, HCN4, SCN1B
sodium ion transmembrane transporter activity (GO:0015081)	4.83	4	SCN3B, SCN5A, HCN4, SCN1B
voltage-gated sodium channel activity (GO:0005248)	6.74	4	SCN3B, SCN5A, HCN4, SCN1B
potassium channel activity (GO:0005267)	4.94	3	KCND3, KCNE3, HCN4
cytoskeletal protein binding (GO:0008092)	3.02	3	CACNA1C, CACNB2, SCN5A
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006)	8.13	3	SCN5A, SCN3B, SCN1B
sodium channel regulator activity (GO:0017080)	6.3	3	GPD1L, SCN3B, SCN1B
voltage-gated potassium channel activity (GO:0005249)	5.24	3	KCND3, KCNE3, HCN4
potassium ion transmembrane transporter activity (GO:0015079)	4.77	3	KCND3, KCNE3, HCN4
calcium channel activity (GO:0005262)	5.03	2	CACNA1C, CACNB2
high voltage-gated calcium channel activity (GO:0008331)	7.34	2	CACNA1C, CACNB2
enzyme binding (GO:0019899)	2.27	2	CACNB2, SCN5A
ion binding (GO:0043167)	1.36	2	CACNA1C, KCND3
voltage-gated sodium channel activity involved in Purkinje myocyte action potential (GO:0086062)	9.05	2	SCN5A, SCN1B
heterocyclic compound binding (GO:1901363)	1.06	2	GPD1L, HCN4
nucleoside phosphate binding (GO:1901265)	1.96	2	GPD1L, HCN4
calcium ion transmembrane transporter activity (GO:0015085)	4.89	2	CACNA1C, CACNB2
voltage-gated calcium channel activity involved in cardiac muscle cell action potential (GO:0086007)	8.13	2	CACNA1C, CACNB2
divalent inorganic cation transmembrane transporter activity (GO:0072509)	4.62	2	CACNA1C, CACNB2
metal ion binding (GO:0046872)	1.41	2	CACNA1C, KCND3
identical protein binding (GO:0042802)	2.63	2	GPD1L, HCN4
cation binding (GO:0043169)	1.4	2	CACNA1C, KCND3
nucleotide binding (GO:0000166)	1.96	2	GPD1L, HCN4
protein kinase binding (GO:0019901)	3.44	2	CACNB2, SCN5A
voltage-gated calcium channel activity involved in AV node cell action potential (GO:0086056)	8.64	2	CACNA1C, CACNB2
protein domain specific binding (GO:0019904)	3.32	2	CACNB2, SCN5A
small molecule binding (GO:0036094)	1.89	2	GPD1L, HCN4
kinase binding (GO:0019900)	3.32	2	CACNB2, SCN5A
organic cyclic compound binding (GO:0097159)	1.05	2	GPD1L, HCN4
calmodulin binding (GO:0005516)	4.55	2	CACNA1C, SCN5A
voltage-gated calcium channel activity (GO:0005245)	6.0	2	CACNA1C, CACNB2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
potassium channel activity (GO:0005267)	-	4.94	0.002	CACNA1C, KCND3, KCNE3, HCN4
cation channel activity (GO:0005261)	-	4.04	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion channel binding (GO:0044325)	-	5.02	0.0	GPD1L, CACNA1C, KCND3, SCN5A, SCN3B
substrate-specific channel activity (GO:0022838)	-	3.67	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006)	-	8.13	0.0	SCN5A, SCN3B, SCN1B
sodium ion transmembrane transporter activity (GO:0015081)	-	4.83	0.0	SCN3B, SCN5A, HCN4, SCN1B
sodium channel inhibitor activity (GO:0019871)	NEW	8.13	0.001	SCN5A, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	-	3.87	0.0	SCN5A, HCN4, KCNE3, SCN3B, KCND3, SCN1B
transmembrane transporter activity (GO:0022857)	-	2.82	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
voltage-gated cation channel activity (GO:0022843)	-	4.83	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
channel regulator activity (GO:0016247)	-	4.88	0.0	GPD1L, SCN5A, KCNE3, SCN3B, KCND3, SCN1B
passive transmembrane transporter activity (GO:0022803)	-	3.6	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
metal ion transmembrane transporter activity (GO:0046873)	-	3.71	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cation transmembrane transporter activity (GO:0008324)	-	3.32	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
sodium channel activity (GO:0005272)	-	6.13	0.0	SCN3B, SCN5A, HCN4, SCN1B
transporter activity (GO:0005215)	-	2.57	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion channel activity (GO:0005216)	-	3.71	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
intracellular ligand-gated ion channel activity (GO:0005217)	NEW	6.41	0.024	CACNA1C, HCN4
substrate-specific transmembrane transporter activity (GO:0022891)	-	2.9	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890)	-	3.49	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
substrate-specific transporter activity (GO:0022892)	-	2.72	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion transmembrane transporter activity (GO:0015075)	-	3.04	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
voltage-gated channel activity (GO:0022832)	-	4.49	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
sodium channel regulator activity (GO:0017080)	-	6.3	0.0	GPD1L, SCN5A, SCN3B, SCN1B
channel activity (GO:0015267)	-	3.6	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
gated channel activity (GO:0022836)	-	3.96	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
voltage-gated potassium channel activity (GO:0005249)	-	5.24	0.001	KCND3, KCNE3, HCN4
voltage-gated sodium channel activity (GO:0005248)	-	6.74	0.0	SCN3B, SCN5A, HCN4, SCN1B
voltage-gated calcium channel activity (GO:0005245)	-	6.0	0.022	CACNA1C, CACNB2
voltage-gated ion channel activity (GO:0005244)	-	4.49	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
potassium ion transmembrane transporter activity (GO:0015079)	-	4.77	0.001	CACNA1C, KCND3, KCNE3, HCN4

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
regulation of membrane potential (GO:0042391)	3.89	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of biological quality (GO:0065008)	1.68	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of transport (GO:0051049)	2.24	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cellular process (GO:0009987)	0.26	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
biological regulation (GO:0065007)	0.39	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
single-organism cellular process (GO:0044763)	0.65	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of ion transport (GO:0043269)	3.4	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of ion transmembrane transport (GO:0034765)	3.77	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of transmembrane transport (GO:0034762)	3.74	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of localization (GO:0032879)	1.94	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of biological process (GO:0050789)	0.45	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
single-organism process (GO:0044699)	0.48	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of heart contraction (GO:0008016)	4.35	8	CACNA1C, GPD1L, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
cation transmembrane transport (GO:0098655)	3.43	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of system process (GO:0044057)	3.53	8	CACNA1C, GPD1L, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
cation transport (GO:0006812)	3.11	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion transport (GO:0006811)	2.66	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
transport (GO:0006810)	1.51	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
localization (GO:0051179)	1.4	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion transmembrane transport (GO:0034220)	3.08	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of blood circulation (GO:1903522)	4.05	8	CACNA1C, GPD1L, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
inorganic cation transmembrane transport (GO:0098662)	3.55	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of multicellular organismal process (GO:0051239)	1.87	8	CACNA1C, GPD1L, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
inorganic ion transmembrane transport (GO:0098660)	3.38	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
metal ion transport (GO:0030001)	3.36	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
establishment of localization (GO:0051234)	1.48	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
transmembrane transport (GO:0055085)	2.72	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
single organism signaling (GO:0044700)	3.25	7	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
multicellular organismal process (GO:0032501)	1.45	7	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
cardiac conduction (GO:0061337)	5.54	7	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
single-multicellular organism process (GO:0044707)	1.78	7	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
regulation of cation transmembrane transport (GO:1904062)	4.4	7	CACNA1C, GPD1L, SCN5A, KCNE3, SCN3B, CACNB2, SCN1B
regulation of cellular process (GO:0050794)	0.5	7	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, SCN3B, SCN1B
regulation of metal ion transport (GO:0010959)	3.94	7	CACNA1C, GPD1L, SCN5A, KCNE3, SCN3B, CACNB2, SCN1B
regulation of heart rate (GO:0002027)	5.29	7	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, CACNB2, SCN1B
multicellular organismal signaling (GO:0035637)	5.36	7	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
signaling (GO:0023052)	3.25	7	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
cardiac muscle cell action potential (GO:0086001)	6.33	6	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, SCN1B
positive regulation of transport (GO:0051050)	2.9	6	GPD1L, SCN5A, KCNE3, SCN3B, CACNB2, SCN1B
regulation of homeostatic process (GO:0032844)	3.65	6	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, SCN1B
positive regulation of ion transport (GO:0043270)	4.36	6	GPD1L, SCN5A, KCNE3, SCN3B, CACNB2, SCN1B
positive regulation of biological process (GO:0048518)	1.2	6	GPD1L, SCN5A, KCNE3, SCN3B, CACNB2, SCN1B
regulation of heart rate by cardiac conduction (GO:0086091)	6.33	6	CACNA1C, SCN5A, HCN4, SCN3B, CACNB2, SCN1B
regulation of ion homeostasis (GO:2000021)	4.44	6	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, SCN1B
action potential (GO:0001508)	5.42	6	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, SCN1B
monovalent inorganic cation transport (GO:0015672)	3.74	6	SCN5A, HCN4, KCNE3, SCN3B, KCND3, SCN1B
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	5	GPD1L, CACNB2, KCNE3, SCN3B, SCN1B
cardiac muscle cell action potential involved in contraction (GO:0086002)	6.47	5	GPD1L, CACNA1C, SCN5A, SCN3B, SCN1B
regulation of transmembrane transporter activity (GO:0022898)	4.52	5	GPD1L, CACNB2, KCNE3, SCN3B, SCN1B
membrane depolarization (GO:0051899)	5.62	5	CACNA1C, CACNB2, SCN5A, SCN3B, SCN1B
regulation of membrane depolarization (GO:0003254)	6.04	5	GPD1L, SCN3B, SCN5A, HCN4, SCN1B
regulation of transporter activity (GO:0032409)	4.45	5	GPD1L, CACNB2, KCNE3, SCN3B, SCN1B
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	7.09	5	CACNA1C, CACNB2, SCN5A, SCN3B, SCN1B
regulation of molecular function (GO:0065009)	1.78	5	GPD1L, CACNB2, KCNE3, SCN3B, SCN1B
membrane depolarization during action potential (GO:0086010)	6.07	5	CACNA1C, CACNB2, SCN5A, SCN3B, SCN1B
single-organism localization (GO:1902578)	2.09	5	CACNA1C, KCND3, KCNE3, SCN3B, HCN4
system process (GO:0003008)	2.3	5	CACNB2, SCN3B, SCN5A, HCN4, SCN1B
regulation of sodium ion transmembrane transport (GO:1902305)	5.86	4	GPD1L, SCN5A, SCN3B, SCN1B
cell communication (GO:0007154)	3.04	4	CACNA1C, CACNB2, SCN5A, SCN1B
muscle contraction (GO:0006936)	4.37	4	SCN3B, SCN5A, HCN4, SCN1B
muscle system process (GO:0003012)	4.18	4	SCN3B, SCN5A, HCN4, SCN1B
response to stimulus (GO:0050896)	1.22	4	KCND3, SCN5A, HCN4, SCN1B
sodium ion transmembrane transport (GO:0035725)	5.23	4	SCN3B, SCN5A, HCN4, SCN1B
sodium ion transport (GO:0006814)	4.75	4	SCN3B, SCN5A, HCN4, SCN1B
single-organism transport (GO:0044765)	2.18	4	CACNA1C, KCND3, KCNE3, HCN4
response to chemical (GO:0042221)	1.98	4	KCND3, SCN5A, HCN4, SCN1B
regulation of postsynaptic membrane potential (GO:0060078)	5.72	4	SCN3B, SCN5A, HCN4, SCN1B
regulation of sodium ion transport (GO:0002028)	5.4	4	GPD1L, SCN5A, SCN3B, SCN1B
positive regulation of sodium ion transport (GO:0010765)	6.23	4	GPD1L, SCN5A, SCN3B, SCN1B
anatomical structure development (GO:0048856)	1.58	3	CACNA1C, SCN5A, SCN3B
regulation of membrane repolarization (GO:0060306)	6.4	3	SCN5A, KCNE3, SCN1B
regulation of calcium ion transmembrane transport (GO:1903169)	4.98	3	CACNA1C, CACNB2, KCNE3
striated muscle contraction (GO:0006941)	5.37	3	SCN5A, SCN3B, SCN1B
regulation of striated muscle contraction (GO:0006942)	5.38	3	CACNA1C, SCN5A, HCN4
membrane depolarization during AV node cell action potential (GO:0086045)	8.34	3	CACNA1C, CACNB2, SCN5A
cellular response to chemical stimulus (GO:0070887)	2.57	3	KCND3, SCN5A, HCN4
cardiac muscle contraction (GO:0060048)	5.88	3	SCN5A, SCN3B, SCN1B
cellular component organization or biogenesis (GO:0071840)	1.22	3	CACNB2, KCND3, SCN3B
ventricular cardiac muscle cell action potential (GO:0086005)	7.02	3	GPD1L, SCN5A, SCN3B
cellular response to stimulus (GO:0051716)	1.97	3	KCND3, SCN5A, HCN4
cellular potassium ion transport (GO:0071804)	4.79	3	KCND3, KCNE3, HCN4
potassium ion transmembrane transport (GO:0071805)	4.79	3	KCND3, KCNE3, HCN4
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	SCN5A, SCN3B, SCN1B
cellular component organization (GO:0016043)	1.24	3	CACNB2, KCND3, SCN3B
regulation of sodium ion transmembrane transporter activity (GO:2000649)	6.09	3	GPD1L, SCN3B, SCN1B
developmental process (GO:0032502)	1.36	3	CACNA1C, SCN5A, SCN3B
regulation of muscle contraction (GO:0006937)	4.75	3	CACNA1C, SCN5A, HCN4
potassium ion transport (GO:0006813)	4.68	3	KCND3, KCNE3, HCN4
neurological system process (GO:0050877)	2.64	3	CACNB2, SCN3B, SCN1B
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373)	7.78	3	GPD1L, SCN5A, SCN3B
regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	7.65	3	SCN5A, SCN3B, SCN1B
regulation of muscle system process (GO:0090257)	4.51	3	CACNA1C, SCN5A, HCN4
regulation of cardiac muscle contraction (GO:0055117)	5.57	3	CACNA1C, SCN5A, HCN4
SA node cell action potential (GO:0086015)	7.94	3	SCN5A, SCN3B, HCN4
regulation of calcium ion transport (GO:0051924)	4.38	3	CACNA1C, CACNB2, KCNE3
positive regulation of ion transmembrane transporter activity (GO:0032414)	5.55	2	CACNB2, KCNE3
positive regulation of transporter activity (GO:0032411)	5.44	2	CACNB2, KCNE3
regulation of cellular localization (GO:0060341)	3.03	2	GPD1L, CACNA1C
chemical synaptic transmission (GO:0007268)	3.98	2	CACNB2, SCN1B
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	6.84	2	SCN5A, SCN1B
membrane depolarization during Purkinje myocyte cell action potential (GO:0086047)	9.04	2	SCN5A, SCN1B
positive regulation of transmembrane transport (GO:0034764)	4.99	2	CACNB2, KCNE3
cell communication involved in cardiac conduction (GO:0086065)	6.73	2	CACNA1C, SCN5A
regulation of protein localization (GO:0032880)	2.88	2	GPD1L, CACNA1C
response to endogenous stimulus (GO:0009719)	2.79	2	KCND3, HCN4
regulation of voltage-gated calcium channel activity (GO:1901385)	6.59	2	CACNB2, KCNE3
anatomical structure morphogenesis (GO:0009653)	2.53	2	CACNA1C, SCN5A
regulation of cell communication (GO:0010646)	1.73	2	GPD1L, CACNA1C
regulation of signaling (GO:0023051)	1.72	2	GPD1L, CACNA1C
cellular response to organic substance (GO:0071310)	2.78	2	KCND3, HCN4
regulation of cardiac muscle cell membrane repolarization (GO:0099623)	6.68	2	SCN5A, SCN1B
positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	6.36	2	CACNB2, KCNE3
positive regulation of heart rate (GO:0010460)	6.59	2	SCN5A, SCN3B
positive regulation of molecular function (GO:0044093)	2.23	2	CACNB2, KCNE3
negative regulation of biological process (GO:0048519)	1.33	2	GPD1L, KCNE3
positive regulation of voltage-gated calcium channel activity (GO:1901387)	7.94	2	CACNB2, KCNE3
positive regulation of calcium ion transmembrane transport (GO:1904427)	5.69	2	CACNB2, KCNE3
cellular response to endogenous stimulus (GO:0071495)	3.33	2	KCND3, HCN4
regulation of cardiac muscle cell contraction (GO:0086004)	6.51	2	CACNA1C, SCN5A
regulation of actin filament-based process (GO:0032970)	3.97	2	CACNA1C, SCN5A
regulation of action potential (GO:0098900)	6.07	2	CACNA1C, SCN5A
regulation of actin filament-based movement (GO:1903115)	6.33	2	CACNA1C, SCN5A
positive regulation of ion transmembrane transport (GO:0034767)	5.05	2	CACNB2, KCNE3
membrane depolarization during atrial cardiac muscle cell action potential (GO:0098912)	9.04	2	CACNA1C, CACNB2
sensory perception (GO:0007600)	2.93	2	CACNB2, SCN3B
calcium ion transport (GO:0006816)	4.33	2	CACNA1C, CACNB2
single-organism developmental process (GO:0044767)	1.49	2	CACNA1C, SCN5A
positive regulation of blood circulation (GO:1903524)	5.16	2	SCN5A, SCN3B
regulation of cation channel activity (GO:2001257)	5.27	2	CACNB2, KCNE3
cell-cell signaling (GO:0007267)	3.35	2	CACNB2, SCN1B
divalent inorganic cation transport (GO:0072511)	4.13	2	CACNA1C, CACNB2
response to organic substance (GO:0010033)	2.2	2	KCND3, HCN4
regulation of calcium ion transmembrane transporter activity (GO:1901019)	5.49	2	CACNB2, KCNE3
regulation of cellular component movement (GO:0051270)	3.08	2	CACNA1C, SCN5A
divalent metal ion transport (GO:0070838)	4.15	2	CACNA1C, CACNB2
positive regulation of calcium ion transport (GO:0051928)	5.06	2	CACNB2, KCNE3
positive regulation of cation transmembrane transport (GO:1904064)	5.17	2	CACNB2, KCNE3
calcium ion transmembrane transport (GO:0070588)	4.67	2	CACNA1C, CACNB2
anterograde trans-synaptic signaling (GO:0098916)	3.98	2	CACNB2, SCN1B
positive regulation of heart contraction (GO:0045823)	6.15	2	SCN5A, SCN3B
synaptic signaling (GO:0099536)	3.98	2	CACNB2, SCN1B
positive regulation of cation channel activity (GO:2001259)	6.17	2	CACNB2, KCNE3
system development (GO:0048731)	2.92	2	CACNA1C, SCN3B
trans-synaptic signaling (GO:0099537)	3.98	2	CACNB2, SCN1B
negative regulation of cellular process (GO:0048523)	1.41	2	GPD1L, KCNE3
positive regulation of cellular process (GO:0048522)	1.3	2	SCN5A, SCN1B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of sodium ion transmembrane transport (GO:1902305)	-	5.86	0.0	GPD1L, SCN5A, SCN3B, SCN1B
neuronal action potential propagation (GO:0019227)	NEW	7.65	0.015	CACNA1C, SCN1B
establishment of localization (GO:0051234)	-	1.48	0.009	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
multicellular organismal signaling (GO:0035637)	-	5.36	0.0	SCN5A, SCN3B, SCN1B
regulation of membrane potential (GO:0042391)	-	3.89	0.0	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, KCND3, SCN1B
regulation of transport (GO:0051049)	-	2.24	0.0	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	-	6.84	0.006	SCN5A, SCN1B
regulation of membrane repolarization (GO:0060306)	-	6.4	0.016	SCN5A, SCN1B
regulation of homeostatic process (GO:0032844)	-	3.65	0.0	GPD1L, CACNA1C, SCN5A, SCN3B, SCN1B
striated muscle contraction (GO:0006941)	-	5.37	0.039	SCN5A, SCN3B, SCN1B
membrane depolarization (GO:0051899)	-	5.62	0.0	CACNA1C, SCN5A, SCN3B, SCN1B
signaling (GO:0023052)	-	3.25	0.0	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	-	7.09	0.0	SCN5A, SCN3B, SCN1B
action potential (GO:0001508)	-	5.42	0.0	GPD1L, CACNA1C, SCN5A, SCN3B, SCN1B
axon guidance (GO:0007411)	NEW	4.44	0.007	CACNA1C, CACNB2, SCN3B, SCN1B
localization (GO:0051179)	-	1.4	0.017	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cell communication involved in cardiac conduction (GO:0086065)	-	6.73	0.0	CACNA1C, SCN5A, SCN3B
cardiac muscle contraction (GO:0060048)	-	5.88	0.0	SCN5A, SCN3B, SCN1B
regulation of transmembrane transport (GO:0034762)	-	3.74	0.0	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ventricular cardiac muscle cell action potential (GO:0086005)	-	7.02	0.0	GPD1L, SCN5A, SCN3B
regulation of localization (GO:0032879)	-	1.94	0.0	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cardiac muscle cell action potential (GO:0086001)	-	6.33	0.0	GPD1L, SCN5A, SCN3B, SCN1B
regulation of system process (GO:0044057)	-	3.53	0.0	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, SCN1B
potassium ion transmembrane transport (GO:0071805)	-	4.79	0.012	CACNA1C, KCND3, KCNE3, HCN4
cardiac conduction (GO:0061337)	-	5.54	0.001	SCN5A, SCN3B, SCN1B
sodium ion transmembrane transport (GO:0035725)	-	5.23	0.001	SCN3B, SCN5A, HCN4, SCN1B
SA node cell to atrial cardiac muscle cell communication (GO:0086070)	NEW	9.04	0.0	SCN5A, SCN3B
regulation of heart rate (GO:0002027)	-	5.29	0.0	GPD1L, SCN3B, SCN5A, HCN4, SCN1B
regulation of transporter activity (GO:0032409)	-	4.45	0.019	CACNA1C, GPD1L, SCN5A, SCN3B, SCN1B
neuron projection guidance (GO:0097485)	NEW	4.43	0.007	CACNA1C, CACNB2, SCN3B, SCN1B
inorganic cation transmembrane transport (GO:0098662)	-	3.55	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of sodium ion transmembrane transporter activity (GO:2000649)	-	6.09	0.0	GPD1L, SCN5A, SCN3B, SCN1B
response to pyrethroid (GO:0046684)	NEW	8.12	0.004	SCN5A, SCN1B
regulation of biological quality (GO:0065008)	-	1.68	0.013	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, KCND3, SCN1B
monovalent inorganic cation transport (GO:0015672)	-	3.74	0.0	CACNA1C, SCN5A, HCN4, KCNE3, SCN3B, KCND3, SCN1B
regulation of sodium ion transport (GO:0002028)	-	5.4	0.0	GPD1L, SCN5A, SCN3B, SCN1B
positive regulation of sodium ion transport (GO:0010765)	-	6.23	0.0	GPD1L, SCN5A, SCN3B, SCN1B
positive regulation of ion transport (GO:0043270)	-	4.36	0.0	GPD1L, CACNB2, SCN5A, SCN3B, SCN1B
transport (GO:0006810)	-	1.51	0.008	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
muscle contraction (GO:0006936)	-	4.37	0.0	CACNA1C, SCN3B, SCN5A, HCN4, SCN1B
positive regulation of transport (GO:0051050)	-	2.9	0.002	GPD1L, CACNB2, SCN5A, SCN3B, SCN1B
potassium ion transport (GO:0006813)	-	4.68	0.02	CACNA1C, KCND3, KCNE3, HCN4
cation transport (GO:0006812)	-	3.11	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion transport (GO:0006811)	-	2.66	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of heart contraction (GO:0008016)	-	4.35	0.0	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, SCN1B
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373)	-	7.78	0.0	GPD1L, SCN5A, SCN3B
adult walking behavior (GO:0007628)	NEW	6.23	0.017	CACNA1C, SCN5A, SCN1B
sodium ion transport (GO:0006814)	-	4.75	0.0	CACNA1C, SCN3B, SCN5A, HCN4, SCN1B
regulation of metal ion transport (GO:0010959)	-	3.94	0.0	CACNA1C, GPD1L, SCN5A, KCNE3, SCN3B, CACNB2, SCN1B
ion transmembrane transport (GO:0034220)	-	3.08	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
single-organism transport (GO:0044765)	-	2.18	0.001	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cellular potassium ion transport (GO:0071804)	-	4.79	0.012	CACNA1C, KCND3, KCNE3, HCN4
metal ion transport (GO:0030001)	-	3.36	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
synaptic transmission (GO:0007268)	-	3.98	0.002	CACNA1C, SCN5A, HCN4, CACNB2, KCND3, SCN1B
cell-cell signaling (GO:0007267)	-	3.35	0.004	CACNA1C, CACNB2, HCN4, KCND3, SCN1B
cell communication (GO:0007154)	-	3.04	0.0	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
membrane depolarization during action potential (GO:0086010)	-	6.07	0.0	CACNA1C, SCN5A, SCN3B, SCN1B
transmembrane transport (GO:0055085)	-	2.72	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	-	7.65	0.0	SCN5A, SCN3B, SCN1B
system process (GO:0003008)	-	2.3	0.002	CACNA1C, SCN5A, HCN4, SCN3B, CACNB2, SCN1B
single organism signaling (GO:0044700)	-	3.25	0.0	CACNA1C, SCN5A, HCN4, CACNB2, SCN3B, KCND3, SCN1B
atrial cardiac muscle cell action potential (GO:0086014)	NEW	7.65	0.013	SCN5A, SCN3B
regulation of ion transmembrane transport (GO:0034765)	-	3.77	0.0	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cardiac muscle cell action potential involved in contraction (GO:0086002)	-	6.47	0.0	GPD1L, SCN5A, SCN3B, SCN1B
muscle system process (GO:0003012)	-	4.18	0.007	CACNA1C, SCN3B, SCN5A, HCN4, SCN1B
regulation of transmembrane transporter activity (GO:0022898)	-	4.52	0.015	GPD1L, CACNA1C, SCN5A, SCN3B, SCN1B
inorganic ion transmembrane transport (GO:0098660)	-	3.38	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of membrane depolarization (GO:0003254)	-	6.04	0.0	GPD1L, SCN5A, SCN3B, SCN1B
regulation of heart rate by cardiac conduction (GO:0086091)	-	6.33	0.0	SCN5A, SCN3B, SCN1B
regulation of ion homeostasis (GO:2000021)	-	4.44	0.0	CACNA1C, GPD1L, SCN5A, SCN3B, SCN1B
calcium ion import (GO:0070509)	NEW	5.57	0.042	CACNA1C, CACNB2
regulation of ion transport (GO:0043269)	-	3.4	0.0	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
response to insecticide (GO:0017085)	NEW	7.33	0.034	SCN5A, SCN1B
cation transmembrane transport (GO:0098655)	-	3.43	0.0	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
regulation of ion transmembrane transporter activity (GO:0032412)	-	4.55	0.0	GPD1L, CACNA1C, SCN5A, SCN3B, SCN1B

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
membrane (GO:0016020)	0.68	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cell part (GO:0044464)	0.11	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
plasma membrane (GO:0005886)	1.39	9	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
protein complex (GO:0043234)	1.51	8	CACNA1C, GPD1L, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
macromolecular complex (GO:0032991)	1.35	8	CACNA1C, GPD1L, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
integral component of membrane (GO:0016021)	1.14	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
membrane part (GO:0044425)	0.95	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
plasma membrane part (GO:0044459)	1.95	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
intrinsic component of membrane (GO:0031224)	1.13	8	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
transmembrane transporter complex (GO:1902495)	4.06	7	CACNA1C, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
transporter complex (GO:1990351)	4.04	7	CACNA1C, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
plasma membrane protein complex (GO:0098797)	3.55	7	CACNA1C, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
membrane protein complex (GO:0098796)	2.84	7	CACNA1C, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
ion channel complex (GO:0034702)	4.18	7	CACNA1C, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
cation channel complex (GO:0034703)	4.69	7	CACNA1C, SCN5A, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
intracellular part (GO:0044424)	0.28	7	CACNA1C, GPD1L, SCN5A, HCN4, KCNE3, SCN3B, KCND3
cytoplasmic part (GO:0044444)	0.82	6	CACNA1C, GPD1L, SCN5A, HCN4, SCN3B, KCND3
neuron part (GO:0097458)	2.64	4	CACNA1C, KCND3, KCNE3, SCN1B
organelle (GO:0043226)	0.4	4	GPD1L, CACNA1C, SCN5A, KCNE3
organelle part (GO:0044422)	0.79	4	CACNA1C, KCND3, SCN5A, SCN3B
cytoplasm (GO:0005737)	1.01	3	CACNA1C, GPD1L, KCNE3
sarcolemma (GO:0042383)	5.2	3	CACNB2, SCN5A, KCND3
intrinsic component of plasma membrane (GO:0031226)	2.53	3	CACNB2, KCND3, HCN4
sodium channel complex (GO:0034706)	6.97	3	SCN5A, SCN3B, SCN1B
integral component of plasma membrane (GO:0005887)	2.57	3	CACNB2, KCND3, HCN4
contractile fiber part (GO:0044449)	4.53	3	CACNA1C, SCN5A, SCN3B
membrane-bounded organelle (GO:0043227)	0.47	3	GPD1L, KCNE3, SCN5A
Z disc (GO:0030018)	5.11	3	CACNA1C, SCN5A, SCN3B
voltage-gated sodium channel complex (GO:0001518)	7.16	3	SCN5A, SCN3B, SCN1B
neuron projection (GO:0043005)	3.12	2	KCND3, KCNE3
intracellular organelle (GO:0043229)	0.51	2	CACNA1C, SCN5A
vesicle (GO:0031982)	1.64	2	GPD1L, KCNE3
L-type voltage-gated calcium channel complex (GO:1990454)	8.01	2	CACNA1C, CACNB2
T-tubule (GO:0030315)	6.09	2	SCN5A, SCN1B
cell-cell contact zone (GO:0044291)	5.69	2	SCN5A, SCN1B
membrane region (GO:0098589)	3.95	2	SCN5A, KCNE3
voltage-gated calcium channel complex (GO:0005891)	6.11	2	CACNA1C, CACNB2
voltage-gated potassium channel complex (GO:0008076)	5.34	2	KCND3, KCNE3
dendrite (GO:0030425)	3.92	2	KCND3, KCNE3
membrane microdomain (GO:0098857)	4.17	2	SCN5A, KCNE3
intercalated disc (GO:0014704)	5.93	2	SCN5A, SCN1B
calcium channel complex (GO:0034704)	5.72	2	CACNA1C, CACNB2
potassium channel complex (GO:0034705)	5.32	2	KCND3, KCNE3
cell-cell junction (GO:0005911)	3.85	2	SCN5A, SCN1B
cell projection (GO:0042995)	2.47	2	KCND3, KCNE3
cell junction (GO:0030054)	2.75	2	SCN5A, SCN1B
membrane raft (GO:0045121)	4.18	2	SCN5A, KCNE3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein complex (GO:0043234)	-	1.51	0.033	CACNA1C, GPD1L, SCN5A, CACNB2, SCN3B, KCND3, SCN1B
intercalated disc (GO:0014704)	-	5.93	0.009	SCN5A, SCN1B
transmembrane transporter complex (GO:1902495)	-	4.06	0.0	CACNA1C, SCN5A, CACNB2, SCN3B, KCND3, SCN1B
T-tubule (GO:0030315)	-	6.09	0.001	CACNA1C, SCN5A, SCN1B
cell-cell contact zone (GO:0044291)	-	5.69	0.012	SCN5A, SCN1B
plasma membrane (GO:0005886)	-	1.39	0.026	CACNA1C, GPD1L, SCN5A, HCN4, CACNB2, SCN3B, KCND3
transporter complex (GO:1990351)	-	4.04	0.0	CACNA1C, SCN5A, CACNB2, SCN3B, KCND3, SCN1B
sodium channel complex (GO:0034706)	-	6.97	0.0	SCN5A, SCN3B, SCN1B
neuron part (GO:0097458)	-	2.64	0.042	CACNA1C, KCND3, HCN4, SCN1B
calcium channel complex (GO:0034704)	-	5.72	0.049	CACNA1C, CACNB2
voltage-gated calcium channel complex (GO:0005891)	-	6.11	0.02	CACNA1C, CACNB2
ion channel complex (GO:0034702)	-	4.18	0.0	CACNA1C, SCN5A, CACNB2, SCN3B, KCND3, SCN1B
cation channel complex (GO:0034703)	-	4.69	0.0	CACNA1C, SCN5A, CACNB2, SCN3B, KCND3, SCN1B
axon part (GO:0033267)	NEW	4.4	0.006	CACNA1C, SCN5A, HCN4, SCN1B
sarcolemma (GO:0042383)	-	5.2	0.0	CACNA1C, KCND3, SCN5A, CACNB2
contractile fiber part (GO:0044449)	-	4.53	0.007	GPD1L, CACNA1C, SCN5A, SCN3B
plasma membrane part (GO:0044459)	-	1.95	0.042	CACNA1C, SCN5A, HCN4, KCNE3, CACNB2, SCN3B, KCND3, SCN1B
Z disc (GO:0030018)	-	5.11	0.001	GPD1L, CACNA1C, SCN5A, SCN3B
voltage-gated sodium channel complex (GO:0001518)	-	7.16	0.0	SCN5A, SCN3B, SCN1B