Gene table of CDKN1B : cyclin dependent kinase inhibitor 1B

Gene-disease associations table

Disease IDDisease nameSource of annotation with CDKN1BOMIM linkNumber of associated genesgenes
PS131100MULTIPLE ENDOCRINE NEOPLASIAClinVar, OMIM link to OMIM 3CDKN1B, RET, MEN1

Download the gene annotation in CSV format

Annotation of the gene CDKN1B

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Small cell lung cancerhsa052226.17
Epstein-Barr virus infectionhsa051694.97
Cell cyclehsa041105.68
MicroRNAs in cancerhsa052065.38
Pathways in cancerhsa052003.98
Viral carcinogenesishsa052035.08
Transcriptional misregulation in cancerhsa052025.21
ErbB signaling pathwayhsa040126.15
FoxO signaling pathwayhsa040685.63
Chronic myeloid leukemiahsa052206.48
HIF-1 signaling pathwayhsa040665.9
Prostate cancerhsa052156.11
Hepatitis Bhsa051615.52
Measleshsa051625.6
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
DNA Damage/Telomere Stress Induced SenescenceR-HSA-25595867.15
PI3K/AKT activationR-HSA-1982036.32
Cellular SenescenceR-HSA-25595835.7
Senescence-Associated Secretory Phenotype (SASP)R-HSA-25595826.77
Cyclin E associated events during G1/S transition R-HSA-692026.96
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Immune SystemR-HSA-1682562.37
Signaling by Rho GTPasesR-HSA-1943154.43
PI3K events in ERBB2 signalingR-HSA-19636426.37
Cell Cycle, MitoticR-HSA-692784.16
GAB1 signalosomeR-HSA-1802926.31
Cell CycleR-HSA-16401703.89
Signaling by ERBB4R-HSA-12363944.7
Adaptive Immune SystemR-HSA-12802183.19
DiseaseR-HSA-16436853.33
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
RHO GTPases activate CITR-HSA-56259008.98
Switching of origins to a post-replicative stateR-HSA-690526.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
PIP3 activates AKT signalingR-HSA-12576046.37
DNA ReplicationR-HSA-693066.25
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
Cellular responses to stressR-HSA-22627524.56
p53-Dependent G1 DNA Damage ResponseR-HSA-695637.15
G1 PhaseR-HSA-692367.73
DAP12 interactionsR-HSA-21721274.56
Cyclin D associated events in G1R-HSA-692317.73
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
p53-Dependent G1/S DNA damage checkpointR-HSA-695807.15
Downstream signaling of activated FGFR3R-HSA-56547084.71
SCF(Skp2)-mediated degradation of p27/p21R-HSA-1875777.18
Cell Cycle CheckpointsR-HSA-696205.64
Signaling by FGFR4R-HSA-56547434.69
Synthesis of DNAR-HSA-692396.37
Signaling by FGFR3R-HSA-56547414.69
Mitotic G1-G1/S phasesR-HSA-4532795.91
Signaling by FGFRR-HSA-1902364.67
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Removal of licensing factors from originsR-HSA-693006.81
Innate Immune SystemR-HSA-1682493.17
Orc1 removal from chromatinR-HSA-689496.85
Signaling by SCF-KITR-HSA-14335574.73
Signaling by ERBB2R-HSA-12279864.66
DAP12 signalingR-HSA-24244914.64
AKT phosphorylates targets in the cytosolR-HSA-1983239.28
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
Constitutive Signaling by AKT1 E17K in CancerR-HSA-56744008.4
Signaling by EGFRR-HSA-1779294.59
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
RHO GTPase EffectorsR-HSA-1952584.94
S PhaseR-HSA-692426.02
Signalling by NGFR-HSA-1665204.23
Cyclin A:Cdk2-associated events at S phase entryR-HSA-696566.94
G1/S TransitionR-HSA-692066.21
Signaling by FGFR1R-HSA-56547364.69
Signaling by FGFR2R-HSA-56547384.68
PI3K events in ERBB4 signalingR-HSA-12503426.37
G1/S DNA Damage CheckpointsR-HSA-696157.08
PI-3K cascade:FGFR3R-HSA-56547106.37
Regulation of DNA replicationR-HSA-693046.75
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by PDGFR-HSA-1867974.53
Signal TransductionR-HSA-1625821.78
Downstream signal transductionR-HSA-1867634.65
Associated GO terms for Molecular function
GO termGO IDGO IC
kinase regulator activityGO:00192074.5
heat shock protein bindingGO:00310725.24
enzyme bindingGO:00198992.27
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
signal transducer activityGO:00048712.28
enzyme inhibitor activityGO:00048573.78
molecular function regulatorGO:00987722.51
transforming growth factor beta receptor, cytoplasmic mediator activityGO:00050727.44
cyclin-dependent protein serine/threonine kinase regulator activityGO:00165386.41
Hsp70 protein bindingGO:00305446.37
receptor signaling protein activityGO:00050574.76
chaperone bindingGO:00510875.34
cysteine-type endopeptidase regulator activity involved in apoptotic processGO:00430286.02
transferase activityGO:00167401.95
protein complex bindingGO:00324033.09
kinase inhibitor activityGO:00192105.25
kinase activityGO:00163012.93
protein kinase regulator activityGO:00198874.6
enzyme regulator activityGO:00302342.85
peptidase regulator activityGO:00611344.37
protein kinase inhibitor activityGO:00048605.28
cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048617.25
protein phosphatase bindingGO:00199034.93
phosphatase bindingGO:00199024.63
protein serine/threonine kinase inhibitor activityGO:00302916.34
cysteine-type endopeptidase activator activity involved in apoptotic processGO:00086566.91
catalytic activityGO:00038241.05
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
protein bindingGO:00055150.46
peptidase activator activityGO:00165046.13
peptidase activator activity involved in apoptotic processGO:00165056.74
enzyme activator activityGO:00080473.56