Disease table of MULTIPLE ENDOCRINE NEOPLASIA OMIM ID: PS131100

Gene-disease associations table

GeneAssociated with MULTIPLE ENDOCRINE NEOPLASIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CDKN1BClinVar, OMIMHGNC link12p13.11PS131100
MEN1ClinVar, OMIM, HUMSAVARHGNC link11q13.12145000, PS131100
RETClinVar, OMIM, HUMSAVARHGNC link10q11.216171300, 155240, PS142623, 209880, 191830, PS131100

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
MEN1YES7CDKN2C, GATA3, CASP8, PRL, TERT, GAST, CDKN1B1CDKN1B
ESR1NO68UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B2RET, CDKN1B
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CDKN1BYES27KAT2B, NFYA, TP53, SP1, KLF4, HDAC3, COPS5, FOXO1, BRCA1, VHL, CUX1, ZNF300, VDR, HDAC1, STAT3, NFYC, HOXB7, NR4A1, UTF1, ING4, FHL2, NFYB, PROX1, MEN1, ESR1, IRF9, MYCN1MEN1
RETYES5TFAP2C, SOX9, ESR1, SOX10, FOXA10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CDKN1BMEN1No2MYC, HSPA8
CDKN1BRETNo2SRC, GRB2
MEN1RETNo1HIST1H3A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CDKN1BMEN1Yesexpression, activation, binding7SUMO1, SMAD4, SMAD3, CTNNB1, UBC, CDKN2B, MYC
CDKN1BRETNo-8STAT3, MAPK8, NR4A2, PTPN11, UBC, CTNNB1, SRC, GRB2
MEN1RETNo-6HRAS, KRAS, PAX2, SOS1, CTNNB1, UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.982RET, CDKN1B
Transcriptional misregulation in cancerhsa052025.212MEN1, CDKN1B

NET-GE enrichment

Term New enriched termICP valueGenes
Transcriptional misregulation in cancer (hsa05202) -5.210.012MEN1, RET, CDKN1B
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
RHO GTPase EffectorsR-HSA-1952584.942MEN1, CDKN1B
Signaling by Rho GTPasesR-HSA-1943154.432MEN1, CDKN1B
Signal TransductionR-HSA-1625821.782MEN1, CDKN1B
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.053MEN1, RET, CDKN1B
transferase activity (GO:0016740) 1.953MEN1, RET, CDKN1B
binding (GO:0005488) 0.183MEN1, RET, CDKN1B
protein binding (GO:0005515) 0.463MEN1, RET, CDKN1B
organic cyclic compound binding (GO:0097159) 1.052MEN1, RET
kinase activity (GO:0016301) 2.932RET, CDKN1B
macromolecular complex binding (GO:0044877) 2.612MEN1, CDKN1B
signal transducer activity (GO:0004871) 2.282RET, CDKN1B
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772RET, CDKN1B
molecular function regulator (GO:0098772) 2.512RET, CDKN1B
heterocyclic compound binding (GO:1901363) 1.062MEN1, RET

NET-GE enrichment

Term New enriched termICP valueGenes
transcription regulatory region sequence-specific DNA binding (GO:0000976) NEW3.240.025MEN1, RET, CDKN1B
RNA polymerase II regulatory region DNA binding (GO:0001012) NEW3.360.017MEN1, RET, CDKN1B
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) NEW3.370.017MEN1, RET, CDKN1B
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) NEW3.290.041MEN1, RET, CDKN1B
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of RNA metabolic process (GO:0051252) 1.523MEN1, RET, CDKN1B
regulation of phosphate metabolic process (GO:0019220) 2.353MEN1, RET, CDKN1B
positive regulation of metabolic process (GO:0009893) 1.743MEN1, RET, CDKN1B
regulation of metabolic process (GO:0019222) 1.023MEN1, RET, CDKN1B
regulation of protein metabolic process (GO:0051246) 1.933MEN1, RET, CDKN1B
positive regulation of cellular metabolic process (GO:0031325) 1.813MEN1, RET, CDKN1B
regulation of cellular metabolic process (GO:0031323) 1.073MEN1, RET, CDKN1B
regulation of cellular biosynthetic process (GO:0031326) 1.383MEN1, RET, CDKN1B
metabolic process (GO:0008152) 0.583MEN1, RET, CDKN1B
signal transduction (GO:0007165) 1.283MEN1, RET, CDKN1B
cellular response to chemical stimulus (GO:0070887) 2.573MEN1, RET, CDKN1B
intracellular signal transduction (GO:0035556) 2.393MEN1, RET, CDKN1B
regulation of biological process (GO:0050789) 0.453MEN1, RET, CDKN1B
single-organism process (GO:0044699) 0.483MEN1, RET, CDKN1B
regulation of primary metabolic process (GO:0080090) 1.083MEN1, RET, CDKN1B
cellular response to stimulus (GO:0051716) 1.973MEN1, RET, CDKN1B
positive regulation of macromolecule metabolic process (GO:0010604) 1.813MEN1, RET, CDKN1B
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463MEN1, RET, CDKN1B
regulation of macromolecule metabolic process (GO:0060255) 1.083MEN1, RET, CDKN1B
cellular response to organic substance (GO:0071310) 2.783MEN1, RET, CDKN1B
biological regulation (GO:0065007) 0.393MEN1, RET, CDKN1B
positive regulation of molecular function (GO:0044093) 2.233MEN1, RET, CDKN1B
regulation of protein modification process (GO:0031399) 2.323MEN1, RET, CDKN1B
positive regulation of biological process (GO:0048518) 1.23MEN1, RET, CDKN1B
regulation of molecular function (GO:0065009) 1.783MEN1, RET, CDKN1B
regulation of gene expression (GO:0010468) 1.373MEN1, RET, CDKN1B
developmental process (GO:0032502) 1.363MEN1, RET, CDKN1B
response to oxygen-containing compound (GO:1901700) 2.573MEN1, RET, CDKN1B
cellular process (GO:0009987) 0.263MEN1, RET, CDKN1B
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433MEN1, RET, CDKN1B
regulation of catalytic activity (GO:0050790) 1.973MEN1, RET, CDKN1B
regulation of biosynthetic process (GO:0009889) 1.373MEN1, RET, CDKN1B
regulation of nucleic acid-templated transcription (GO:1903506) 1.553MEN1, RET, CDKN1B
regulation of cellular process (GO:0050794) 0.53MEN1, RET, CDKN1B
single-organism developmental process (GO:0044767) 1.493MEN1, RET, CDKN1B
response to stress (GO:0006950) 1.83MEN1, RET, CDKN1B
single-organism cellular process (GO:0044763) 0.653MEN1, RET, CDKN1B
regulation of nitrogen compound metabolic process (GO:0051171) 1.363MEN1, RET, CDKN1B
regulation of multicellular organismal process (GO:0051239) 1.873MEN1, RET, CDKN1B
regulation of RNA biosynthetic process (GO:2001141) 1.553MEN1, RET, CDKN1B
response to chemical (GO:0042221) 1.983MEN1, RET, CDKN1B
response to organic substance (GO:0010033) 2.23MEN1, RET, CDKN1B
regulation of phosphorylation (GO:0042325) 2.53MEN1, RET, CDKN1B
regulation of phosphorus metabolic process (GO:0051174) 2.353MEN1, RET, CDKN1B
regulation of cellular protein metabolic process (GO:0032268) 1.993MEN1, RET, CDKN1B
response to stimulus (GO:0050896) 1.223MEN1, RET, CDKN1B
anatomical structure development (GO:0048856) 1.583MEN1, RET, CDKN1B
cellular metabolic process (GO:0044237) 0.693MEN1, RET, CDKN1B
regulation of transcription, DNA-templated (GO:0006355) 1.563MEN1, RET, CDKN1B
phosphate-containing compound metabolic process (GO:0006796) 2.163MEN1, RET, CDKN1B
regulation of macromolecule biosynthetic process (GO:0010556) 1.433MEN1, RET, CDKN1B
phosphorus metabolic process (GO:0006793) 2.153MEN1, RET, CDKN1B
regulation of protein phosphorylation (GO:0001932) 2.573MEN1, RET, CDKN1B
phosphorylation (GO:0016310) 2.633MEN1, RET, CDKN1B
positive regulation of cellular process (GO:0048522) 1.33MEN1, RET, CDKN1B
regulation of kinase activity (GO:0043549) 3.072MEN1, CDKN1B
positive regulation of response to stimulus (GO:0048584) 2.182MEN1, RET
regulation of response to stimulus (GO:0048583) 1.542MEN1, RET
negative regulation of epithelial cell proliferation (GO:0050680) 4.982MEN1, CDKN1B
cell surface receptor signaling pathway (GO:0007166) 2.092RET, CDKN1B
cellular component organization or biogenesis (GO:0071840) 1.222MEN1, RET
single-organism metabolic process (GO:0044710) 1.632MEN1, RET
negative regulation of cell cycle (GO:0045786) 3.672MEN1, CDKN1B
regulation of signal transduction (GO:0009966) 1.842MEN1, RET
cellular developmental process (GO:0048869) 1.822MEN1, RET
MAPK cascade (GO:0000165) 3.912MEN1, RET
peptidyl-amino acid modification (GO:0018193) 2.982MEN1, RET
animal organ development (GO:0048513) 2.532MEN1, RET
negative regulation of molecular function (GO:0044092) 2.742MEN1, CDKN1B
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) 4.432RET, CDKN1B
negative regulation of biological process (GO:0048519) 1.332MEN1, CDKN1B
regulation of cell proliferation (GO:0042127) 2.412MEN1, CDKN1B
regulation of protein kinase activity (GO:0045859) 3.152MEN1, CDKN1B
regulation of proteolysis (GO:0030162) 3.22RET, CDKN1B
response to peptide hormone (GO:0043434) 4.062MEN1, CDKN1B
positive regulation of phosphorylation (GO:0042327) 2.92RET, CDKN1B
negative regulation of phosphorylation (GO:0042326) 3.72MEN1, CDKN1B
response to monosaccharide (GO:0034284) 4.772MEN1, CDKN1B
protein metabolic process (GO:0019538) 1.452MEN1, RET
response to organonitrogen compound (GO:0010243) 3.22MEN1, CDKN1B
cellular response to stress (GO:0033554) 2.512MEN1, CDKN1B
regulation of cyclin-dependent protein kinase activity (GO:1904029) 5.212MEN1, CDKN1B
negative regulation of kinase activity (GO:0033673) 4.222MEN1, CDKN1B
negative regulation of metabolic process (GO:0009892) 1.932MEN1, CDKN1B
negative regulation of biosynthetic process (GO:0009890) 2.472MEN1, CDKN1B
positive regulation of biosynthetic process (GO:0009891) 2.292MEN1, RET
negative regulation of gene expression (GO:0010629) 2.482MEN1, CDKN1B
positive regulation of gene expression (GO:0010628) 2.352MEN1, RET
negative regulation of protein serine/threonine kinase activity (GO:0071901) 4.922MEN1, CDKN1B
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582MEN1, CDKN1B
regulation of apoptotic process (GO:0042981) 2.52RET, CDKN1B
cellular protein metabolic process (GO:0044267) 1.632MEN1, RET
positive regulation of hydrolase activity (GO:0051345) 2.912RET, CDKN1B
negative regulation of transferase activity (GO:0051348) 3.872MEN1, CDKN1B
cellular component organization (GO:0016043) 1.242MEN1, RET
negative regulation of cyclin-dependent protein kinase activity (GO:1904030) 6.432MEN1, CDKN1B
signal transduction by protein phosphorylation (GO:0023014) 3.792MEN1, RET
regulation of biological quality (GO:0065008) 1.682MEN1, RET
positive regulation of cellular component organization (GO:0051130) 2.682RET, CDKN1B
positive regulation of catalytic activity (GO:0043085) 2.42RET, CDKN1B
regulation of developmental process (GO:0050793) 2.12RET, CDKN1B
tissue development (GO:0009888) 3.272MEN1, RET
regulation of cell cycle phase transition (GO:1901987) 4.152MEN1, CDKN1B
macromolecule modification (GO:0043412) 1.732MEN1, RET
protein modification process (GO:0036211) 1.792MEN1, RET
negative regulation of macromolecule metabolic process (GO:0010605) 2.012MEN1, CDKN1B
regulation of intracellular signal transduction (GO:1902531) 2.312MEN1, RET
primary metabolic process (GO:0044238) 0.692MEN1, RET
negative regulation of cell cycle phase transition (GO:1901988) 4.742MEN1, CDKN1B
regulation of hydrolase activity (GO:0051336) 2.532RET, CDKN1B
negative regulation of protein modification process (GO:0031400) 3.42MEN1, CDKN1B
positive regulation of protein modification process (GO:0031401) 2.72RET, CDKN1B
regulation of transferase activity (GO:0051338) 2.882MEN1, CDKN1B
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392MEN1, RET
negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736) 6.592MEN1, CDKN1B
positive regulation of signal transduction (GO:0009967) 2.52MEN1, RET
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532MEN1, CDKN1B
negative regulation of phosphorus metabolic process (GO:0010563) 3.452MEN1, CDKN1B
regulation of cell adhesion (GO:0030155) 3.272MEN1, RET
cell differentiation (GO:0030154) 2.142MEN1, RET
regulation of cellular component organization (GO:0051128) 2.012RET, CDKN1B
positive regulation of signaling (GO:0023056) 2.412MEN1, RET
regulation of signaling (GO:0023051) 1.722MEN1, RET
positive regulation of cell communication (GO:0010647) 2.412MEN1, RET
regulation of cell communication (GO:0010646) 1.732MEN1, RET
negative regulation of catalytic activity (GO:0043086) 3.02MEN1, CDKN1B
cell cycle (GO:0007049) 3.142MEN1, CDKN1B
response to endogenous stimulus (GO:0009719) 2.792MEN1, CDKN1B
negative regulation of protein metabolic process (GO:0051248) 2.822MEN1, CDKN1B
positive regulation of phosphorus metabolic process (GO:0010562) 2.782RET, CDKN1B
negative regulation of multicellular organismal process (GO:0051241) 2.842MEN1, CDKN1B
regulation of cell cycle process (GO:0010564) 3.52MEN1, CDKN1B
positive regulation of protein metabolic process (GO:0051247) 2.432RET, CDKN1B
positive regulation of cellular protein metabolic process (GO:0032270) 2.492RET, CDKN1B
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562MEN1, RET
negative regulation of cell proliferation (GO:0008285) 3.262MEN1, CDKN1B
multicellular organismal process (GO:0032501) 1.452RET, CDKN1B
cellular response to oxygen-containing compound (GO:1901701) 3.222MEN1, RET
cellular macromolecule metabolic process (GO:0044260) 0.932MEN1, RET
cellular response to DNA damage stimulus (GO:0006974) 3.172MEN1, CDKN1B
regulation of cell differentiation (GO:0045595) 2.422MEN1, RET
negative regulation of transcription, DNA-templated (GO:0045892) 2.752MEN1, CDKN1B
response to acid chemical (GO:0001101) 4.052RET, CDKN1B
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) 4.962RET, CDKN1B
regulation of localization (GO:0032879) 1.942RET, CDKN1B
negative regulation of cellular protein metabolic process (GO:0032269) 2.882MEN1, CDKN1B
regulation of epithelial cell proliferation (GO:0050678) 4.062MEN1, CDKN1B
response to hormone (GO:0009725) 3.332MEN1, CDKN1B
negative regulation of RNA metabolic process (GO:0051253) 2.662MEN1, CDKN1B
response to drug (GO:0042493) 3.712RET, CDKN1B
positive regulation of RNA metabolic process (GO:0051254) 2.512MEN1, RET
macromolecule metabolic process (GO:0043170) 0.832MEN1, RET
positive regulation of RNA biosynthetic process (GO:1902680) 2.542MEN1, RET
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712MEN1, CDKN1B
positive regulation of proteolysis (GO:0045862) 3.862RET, CDKN1B
response to nitrogen compound (GO:1901698) 3.122MEN1, CDKN1B
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) 5.262RET, CDKN1B
positive regulation of cellular biosynthetic process (GO:0031328) 2.32MEN1, RET
negative regulation of cellular biosynthetic process (GO:0031327) 2.492MEN1, CDKN1B
negative regulation of cellular metabolic process (GO:0031324) 2.012MEN1, CDKN1B
positive regulation of cysteine-type endopeptidase activity (GO:2001056) 4.882RET, CDKN1B
negative regulation of cell cycle process (GO:0010948) 4.372MEN1, CDKN1B
positive regulation of cell death (GO:0010942) 3.322RET, CDKN1B
regulation of cell death (GO:0010941) 2.432RET, CDKN1B
regulation of cysteine-type endopeptidase activity (GO:2000116) 4.372RET, CDKN1B
response to lipid (GO:0033993) 3.112RET, CDKN1B
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62MEN1, CDKN1B
positive regulation of apoptotic process (GO:0043065) 3.382RET, CDKN1B
organic substance metabolic process (GO:0071704) 0.632MEN1, RET
regulation of programmed cell death (GO:0043067) 2.492RET, CDKN1B
negative regulation of phosphate metabolic process (GO:0045936) 3.452MEN1, CDKN1B
response to peptide (GO:1901652) 3.942MEN1, CDKN1B
positive regulation of programmed cell death (GO:0043068) 3.382RET, CDKN1B
protein phosphorylation (GO:0006468) 2.892MEN1, RET
negative regulation of protein kinase activity (GO:0006469) 4.292MEN1, CDKN1B
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352MEN1, RET
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552MEN1, CDKN1B
positive regulation of phosphate metabolic process (GO:0045937) 2.782RET, CDKN1B
regulation of peptidase activity (GO:0052547) 3.752RET, CDKN1B
regulation of endopeptidase activity (GO:0052548) 3.82RET, CDKN1B
cellular protein modification process (GO:0006464) 1.792MEN1, RET
negative regulation of RNA biosynthetic process (GO:1902679) 2.72MEN1, CDKN1B
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472MEN1, CDKN1B
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292MEN1, RET
positive regulation of endopeptidase activity (GO:0010950) 4.782RET, CDKN1B
positive regulation of peptidase activity (GO:0010952) 4.72RET, CDKN1B
response to hexose (GO:0009746) 4.822MEN1, CDKN1B
response to abiotic stimulus (GO:0009628) 2.82MEN1, CDKN1B
regulation of cellular component movement (GO:0051270) 3.082RET, CDKN1B
response to carbohydrate (GO:0009743) 4.622MEN1, CDKN1B
regulation of cell cycle (GO:0051726) 2.932MEN1, CDKN1B
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) 5.262MEN1, CDKN1B
response to glucose (GO:0009749) 4.862MEN1, CDKN1B
regulation of cell cycle G1/S phase transition (GO:1902806) 4.742MEN1, CDKN1B
negative regulation of cell cycle G1/S phase transition (GO:1902807) 5.142MEN1, CDKN1B
regulation of multicellular organismal development (GO:2000026) 2.312RET, CDKN1B
negative regulation of protein phosphorylation (GO:0001933) 3.792MEN1, CDKN1B
positive regulation of protein phosphorylation (GO:0001934) 2.952RET, CDKN1B
negative regulation of cellular process (GO:0048523) 1.412MEN1, CDKN1B
positive regulation of transcription, DNA-templated (GO:0045893) 2.562MEN1, RET

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of cysteine-type endopeptidase activity (GO:2001056) -4.880.0MEN1, RET, CDKN1B
mitotic DNA damage checkpoint (GO:0044773) NEW6.20.039MEN1, CDKN1B
neuron migration (GO:0001764) NEW5.00.02MEN1, RET, CDKN1B
enzyme linked receptor protein signaling pathway (GO:0007167) NEW3.240.037MEN1, RET, CDKN1B
negative regulation of JNK cascade (GO:0046329) NEW6.230.029MEN1, CDKN1B
signal transduction by phosphorylation (GO:0023014) -3.790.03MEN1, RET, CDKN1B
activation of cysteine-type endopeptidase activity (GO:0097202) NEW7.240.036RET, CDKN1B
regulation of cysteine-type endopeptidase activity (GO:2000116) -4.370.001MEN1, RET, CDKN1B
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) -5.260.032RET, CDKN1B
MAPK cascade (GO:0000165) -3.910.018MEN1, RET, CDKN1B
zymogen activation (GO:0031638) NEW6.330.047RET, CDKN1B
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) -4.430.026MEN1, RET, CDKN1B
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) -4.960.0MEN1, RET, CDKN1B
positive regulation of cellular component organization (GO:0051130) -2.680.029MEN1, RET, CDKN1B
positive regulation of endopeptidase activity (GO:0010950) -4.780.0MEN1, RET, CDKN1B
regulation of peptidase activity (GO:0052547) -3.750.005MEN1, RET, CDKN1B
regulation of endopeptidase activity (GO:0052548) -3.80.004MEN1, RET, CDKN1B
negative regulation of stress-activated protein kinase signaling cascade (GO:0070303) NEW6.020.038MEN1, CDKN1B
negative regulation of stress-activated MAPK cascade (GO:0032873) NEW6.020.038MEN1, CDKN1B
regulation of proteolysis (GO:0030162) -3.20.012MEN1, RET, CDKN1B
response to lithium ion (GO:0010226) NEW6.430.026MEN1, CDKN1B
positive regulation of peptidase activity (GO:0010952) -4.70.008MEN1, RET, CDKN1B
negative regulation of cellular component movement (GO:0051271) NEW4.220.04MEN1, RET, CDKN1B
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) -5.260.041MEN1, CDKN1B
negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736) -6.590.002MEN1, CDKN1B
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.013MEN1, RET, CDKN1B
protein complex (GO:0043234) 1.513MEN1, RET, CDKN1B
macromolecular complex (GO:0032991) 1.353MEN1, RET, CDKN1B
intracellular membrane-bounded organelle (GO:0043231) 0.63MEN1, RET, CDKN1B
cell part (GO:0044464) 0.113MEN1, RET, CDKN1B
cytoplasmic part (GO:0044444) 0.823MEN1, RET, CDKN1B
intracellular organelle part (GO:0044446) 0.813MEN1, RET, CDKN1B
intracellular organelle (GO:0043229) 0.513MEN1, RET, CDKN1B
intracellular part (GO:0044424) 0.283MEN1, RET, CDKN1B
membrane-bounded organelle (GO:0043227) 0.473MEN1, RET, CDKN1B
organelle (GO:0043226) 0.43MEN1, RET, CDKN1B
organelle part (GO:0044422) 0.793MEN1, RET, CDKN1B
catalytic complex (GO:1902494) 2.92MEN1, CDKN1B
vacuole (GO:0005773) 2.922RET, CDKN1B
nucleus (GO:0005634) 1.072MEN1, CDKN1B
nucleoplasm (GO:0005654) 1.892MEN1, CDKN1B
nuclear part (GO:0044428) 1.552MEN1, CDKN1B
transferase complex (GO:1990234) 3.322MEN1, CDKN1B
endosome (GO:0005768) 3.252RET, CDKN1B
cytosol (GO:0005829) 1.682MEN1, CDKN1B