Gene table of MEN1 : menin 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with MEN1	OMIM link	Number of associated genes	genes
PS131100	MULTIPLE ENDOCRINE NEOPLASIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	CDKN1B, RET, MEN1
145000	HYPERPARATHYROIDISM 1	ClinVar, HUMSAVAR	link to OMIM	2	CDC73, MEN1

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Transcriptional misregulation in cancer	hsa05202	5.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
RHO GTPase Effectors	R-HSA-195258	4.94
Signaling by Wnt	R-HSA-195721	4.79
formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.18
Generic Transcription Pathway	R-HSA-212436	3.86
Gene Expression	R-HSA-74160	2.72
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.81
Signaling by Rho GTPases	R-HSA-194315	4.43
Signal Transduction	R-HSA-162582	1.78
deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.59
TCF dependent signaling in response to WNT	R-HSA-201681	5.36
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.56
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.03
RHO GTPases activate IQGAPs	R-HSA-5626467	8.34

Associated GO terms for Molecular function

GO term	GO ID	GO IC
histone-lysine N-methyltransferase activity	GO:0018024	5.93
histone methyltransferase activity	GO:0042054	5.68
lysine N-methyltransferase activity	GO:0016278	5.7
protein-lysine N-methyltransferase activity	GO:0016279	5.71
protein methyltransferase activity	GO:0008276	5.33
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
methyltransferase activity	GO:0008168	4.35
heterocyclic compound binding	GO:1901363	1.06
structure-specific DNA binding	GO:0043566	4.98
transferase activity	GO:0016740	1.95
transferase activity, transferring one-carbon groups	GO:0016741	4.3
R-SMAD binding	GO:0070412	6.65
S-adenosylmethionine-dependent methyltransferase activity	GO:0008757	4.81
double-stranded DNA binding	GO:0003690	3.09
Y-form DNA binding	GO:0000403	8.35
regulatory region nucleic acid binding	GO:0001067	3.03
DNA secondary structure binding	GO:0000217	6.6
protein binding, bridging	GO:0030674	4.68
SMAD binding	GO:0046332	5.45
catalytic activity	GO:0003824	1.05
N-methyltransferase activity	GO:0008170	5.26
binding, bridging	GO:0060090	4.57
transcription regulatory region DNA binding	GO:0044212	3.03
four-way junction DNA binding	GO:0000400	7.03
protein N-terminus binding	GO:0047485	5.11
organic cyclic compound binding	GO:0097159	1.05
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
chromatin binding	GO:0003682	3.64