Disease table of HYPERPARATHYROIDISM 1 OMIM ID: 145000

Gene-disease associations table

GeneAssociated with HYPERPARATHYROIDISM 1 inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MEN1ClinVar, HUMSAVARHGNC link11q13.12145000, PS131100
CDC73ClinVar, OMIM, HUMSAVARHGNC link1q31.23608266, 145001, 145000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
MEN1YES7CDKN2C, GATA3, CASP8, PRL, TERT, GAST, CDKN1B0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MEN1CDC73No11MYC, KMT2A, POLR2A, HSPA4, MYH9, RBBP5, TCF7L2, CTNNB1, SNW1, ASH2L, HIST1H3A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MEN1CDC73No-6POLR2A, LEF1, TCF7L2, RBBP5, CTNNB1, UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
TCF dependent signaling in response to WNTR-HSA-2016815.362MEN1, CDC73
Signaling by WntR-HSA-1957214.792MEN1, CDC73
formation of the beta-catenin:TCF transactivating complexR-HSA-2017227.182MEN1, CDC73
Signal TransductionR-HSA-1625821.782MEN1, CDC73

NET-GE enrichment

Term New enriched termICP valueGenes
TCF dependent signaling in response to WNT (R-HSA-201681) -5.360.009MEN1, CDC73
Signaling by Wnt (R-HSA-195721) -4.790.021MEN1, CDC73
formation of the beta-catenin:TCF transactivating complex (R-HSA-201722) -7.180.001MEN1, CDC73
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
macromolecular complex binding (GO:0044877) 2.612MEN1, CDC73
binding (GO:0005488) 0.182MEN1, CDC73
protein binding (GO:0005515) 0.462MEN1, CDC73
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.082MEN1, CDC73
regulation of metabolic process (GO:0019222) 1.022MEN1, CDC73
positive regulation of response to stimulus (GO:0048584) 2.182MEN1, CDC73
regulation of response to stimulus (GO:0048583) 1.542MEN1, CDC73
negative regulation of epithelial cell proliferation (GO:0050680) 4.982MEN1, CDC73
signal transduction (GO:0007165) 1.282MEN1, CDC73
organic cyclic compound biosynthetic process (GO:1901362) 1.662MEN1, CDC73
cellular component organization or biogenesis (GO:0071840) 1.222MEN1, CDC73
cellular response to stimulus (GO:0051716) 1.972MEN1, CDC73
negative regulation of cell cycle (GO:0045786) 3.672MEN1, CDC73
positive regulation of macromolecule metabolic process (GO:0010604) 1.812MEN1, CDC73
regulation of signal transduction (GO:0009966) 1.842MEN1, CDC73
positive regulation of signal transduction (GO:0009967) 2.52MEN1, CDC73
positive regulation of biological process (GO:0048518) 1.22MEN1, CDC73
negative regulation of biological process (GO:0048519) 1.332MEN1, CDC73
histone modification (GO:0016570) 3.912MEN1, CDC73
regulation of cell proliferation (GO:0042127) 2.412MEN1, CDC73
regulation of macromolecule metabolic process (GO:0060255) 1.082MEN1, CDC73
regulation of RNA biosynthetic process (GO:2001141) 1.552MEN1, CDC73
response to organic substance (GO:0010033) 2.22MEN1, CDC73
heterocycle metabolic process (GO:0046483) 1.312MEN1, CDC73
protein metabolic process (GO:0019538) 1.452MEN1, CDC73
aromatic compound biosynthetic process (GO:0019438) 1.72MEN1, CDC73
covalent chromatin modification (GO:0016569) 3.892MEN1, CDC73
cellular component assembly (GO:0022607) 2.142MEN1, CDC73
negative regulation of metabolic process (GO:0009892) 1.932MEN1, CDC73
positive regulation of metabolic process (GO:0009893) 1.742MEN1, CDC73
negative regulation of biosynthetic process (GO:0009890) 2.472MEN1, CDC73
positive regulation of biosynthetic process (GO:0009891) 2.292MEN1, CDC73
metabolic process (GO:0008152) 0.582MEN1, CDC73
negative regulation of gene expression (GO:0010629) 2.482MEN1, CDC73
nitrogen compound metabolic process (GO:0006807) 1.132MEN1, CDC73
regulation of biological process (GO:0050789) 0.452MEN1, CDC73
nucleic acid-templated transcription (GO:0097659) 1.912MEN1, CDC73
cellular protein metabolic process (GO:0044267) 1.632MEN1, CDC73
cellular macromolecule metabolic process (GO:0044260) 0.932MEN1, CDC73
cellular component organization (GO:0016043) 1.242MEN1, CDC73
macromolecular complex assembly (GO:0065003) 2.552MEN1, CDC73
biological regulation (GO:0065007) 0.392MEN1, CDC73
organic cyclic compound metabolic process (GO:1901360) 1.262MEN1, CDC73
regulation of biological quality (GO:0065008) 1.682MEN1, CDC73
heterocycle biosynthetic process (GO:0018130) 1.72MEN1, CDC73
regulation of biosynthetic process (GO:0009889) 1.372MEN1, CDC73
regulation of cellular process (GO:0050794) 0.52MEN1, CDC73
regulation of cell cycle phase transition (GO:1901987) 4.152MEN1, CDC73
macromolecule modification (GO:0043412) 1.732MEN1, CDC73
protein modification process (GO:0036211) 1.792MEN1, CDC73
regulation of multicellular organismal process (GO:0051239) 1.872MEN1, CDC73
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722MEN1, CDC73
negative regulation of macromolecule metabolic process (GO:0010605) 2.012MEN1, CDC73
negative regulation of cell cycle phase transition (GO:1901988) 4.742MEN1, CDC73
RNA metabolic process (GO:0016070) 1.592MEN1, CDC73
negative regulation of RNA biosynthetic process (GO:1902679) 2.72MEN1, CDC73
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592MEN1, CDC73
response to stimulus (GO:0050896) 1.222MEN1, CDC73
regulation of transcription, DNA-templated (GO:0006355) 1.562MEN1, CDC73
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392MEN1, CDC73
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242MEN1, CDC73
transcription, DNA-templated (GO:0006351) 1.912MEN1, CDC73
cellular developmental process (GO:0048869) 1.822MEN1, CDC73
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532MEN1, CDC73
RNA biosynthetic process (GO:0032774) 1.842MEN1, CDC73
positive regulation of signaling (GO:0023056) 2.412MEN1, CDC73
cellular biosynthetic process (GO:0044249) 1.372MEN1, CDC73
cellular nitrogen compound metabolic process (GO:0034641) 1.222MEN1, CDC73
cellular response to chemical stimulus (GO:0070887) 2.572MEN1, CDC73
regulation of signaling (GO:0023051) 1.722MEN1, CDC73
positive regulation of cell communication (GO:0010647) 2.412MEN1, CDC73
regulation of cell communication (GO:0010646) 1.732MEN1, CDC73
single-organism process (GO:0044699) 0.482MEN1, CDC73
nucleobase-containing compound metabolic process (GO:0006139) 1.352MEN1, CDC73
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122MEN1, CDC73
negative regulation of multicellular organismal process (GO:0051241) 2.842MEN1, CDC73
regulation of cell cycle process (GO:0010564) 3.52MEN1, CDC73
negative regulation of cellular biosynthetic process (GO:0031327) 2.492MEN1, CDC73
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562MEN1, CDC73
negative regulation of cell proliferation (GO:0008285) 3.262MEN1, CDC73
primary metabolic process (GO:0044238) 0.692MEN1, CDC73
cellular process (GO:0009987) 0.262MEN1, CDC73
cellular aromatic compound metabolic process (GO:0006725) 1.32MEN1, CDC73
regulation of nucleic acid-templated transcription (GO:1903506) 1.552MEN1, CDC73
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712MEN1, CDC73
negative regulation of cell differentiation (GO:0045596) 3.332MEN1, CDC73
cellular macromolecule biosynthetic process (GO:0034645) 1.662MEN1, CDC73
negative regulation of transcription, DNA-templated (GO:0045892) 2.752MEN1, CDC73
positive regulation of transcription, DNA-templated (GO:0045893) 2.562MEN1, CDC73
cell cycle (GO:0007049) 3.142MEN1, CDC73
regulation of epithelial cell proliferation (GO:0050678) 4.062MEN1, CDC73
negative regulation of RNA metabolic process (GO:0051253) 2.662MEN1, CDC73
regulation of RNA metabolic process (GO:0051252) 1.522MEN1, CDC73
positive regulation of RNA metabolic process (GO:0051254) 2.512MEN1, CDC73
macromolecule metabolic process (GO:0043170) 0.832MEN1, CDC73
positive regulation of RNA biosynthetic process (GO:1902680) 2.542MEN1, CDC73
positive regulation of gene expression (GO:0010628) 2.352MEN1, CDC73
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812MEN1, CDC73
developmental process (GO:0032502) 1.362MEN1, CDC73
positive regulation of cellular biosynthetic process (GO:0031328) 2.32MEN1, CDC73
macromolecular complex subunit organization (GO:0043933) 2.142MEN1, CDC73
regulation of cellular biosynthetic process (GO:0031326) 1.382MEN1, CDC73
positive regulation of cellular metabolic process (GO:0031325) 1.812MEN1, CDC73
negative regulation of cellular metabolic process (GO:0031324) 2.012MEN1, CDC73
regulation of cellular metabolic process (GO:0031323) 1.072MEN1, CDC73
nucleic acid metabolic process (GO:0090304) 1.462MEN1, CDC73
negative regulation of cell cycle process (GO:0010948) 4.372MEN1, CDC73
protein complex subunit organization (GO:0071822) 2.62MEN1, CDC73
chromatin organization (GO:0006325) 3.282MEN1, CDC73
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462MEN1, CDC73
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62MEN1, CDC73
organic substance metabolic process (GO:0071704) 0.632MEN1, CDC73
cellular response to organic substance (GO:0071310) 2.782MEN1, CDC73
regulation of macromolecule biosynthetic process (GO:0010556) 1.432MEN1, CDC73
beta-catenin-TCF complex assembly (GO:1904837) 6.332MEN1, CDC73
regulation of gene expression (GO:0010468) 1.372MEN1, CDC73
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352MEN1, CDC73
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552MEN1, CDC73
organic substance biosynthetic process (GO:1901576) 1.342MEN1, CDC73
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432MEN1, CDC73
protein complex assembly (GO:0006461) 2.782MEN1, CDC73
cellular protein modification process (GO:0006464) 1.792MEN1, CDC73
single-organism developmental process (GO:0044767) 1.492MEN1, CDC73
biosynthetic process (GO:0009058) 1.322MEN1, CDC73
macromolecule biosynthetic process (GO:0009059) 1.612MEN1, CDC73
single-organism cellular process (GO:0044763) 0.652MEN1, CDC73
regulation of nitrogen compound metabolic process (GO:0051171) 1.362MEN1, CDC73
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472MEN1, CDC73
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292MEN1, CDC73
response to chemical (GO:0042221) 1.982MEN1, CDC73
response to oxygen-containing compound (GO:1901700) 2.572MEN1, CDC73
cellular response to oxygen-containing compound (GO:1901701) 3.222MEN1, CDC73
regulation of cell cycle (GO:0051726) 2.932MEN1, CDC73
regulation of cell differentiation (GO:0045595) 2.422MEN1, CDC73
cellular metabolic process (GO:0044237) 0.692MEN1, CDC73
regulation of cell cycle G1/S phase transition (GO:1902806) 4.742MEN1, CDC73
negative regulation of cell cycle G1/S phase transition (GO:1902807) 5.142MEN1, CDC73
negative regulation of cellular process (GO:0048523) 1.412MEN1, CDC73
positive regulation of cellular process (GO:0048522) 1.32MEN1, CDC73

NET-GE enrichment

Term New enriched termICP valueGenes
histone lysine methylation (GO:0034968) NEW5.570.031MEN1, CDC73
cell fate commitment (GO:0045165) NEW4.720.018MEN1, CDC73
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.012MEN1, CDC73
nucleoplasm (GO:0005654) 1.892MEN1, CDC73
nuclear part (GO:0044428) 1.552MEN1, CDC73
macromolecular complex (GO:0032991) 1.352MEN1, CDC73
intracellular membrane-bounded organelle (GO:0043231) 0.62MEN1, CDC73
nucleus (GO:0005634) 1.072MEN1, CDC73
cell part (GO:0044464) 0.112MEN1, CDC73
intracellular organelle part (GO:0044446) 0.812MEN1, CDC73
chromosome, telomeric region (GO:0000781) 4.92MEN1, CDC73
nuclear chromosome part (GO:0044454) 3.672MEN1, CDC73
intracellular organelle (GO:0043229) 0.512MEN1, CDC73
nucleoplasm part (GO:0044451) 3.222MEN1, CDC73
nuclear chromosome, telomeric region (GO:0000784) 5.162MEN1, CDC73
intracellular part (GO:0044424) 0.282MEN1, CDC73
protein complex (GO:0043234) 1.512MEN1, CDC73
chromosomal part (GO:0044427) 3.182MEN1, CDC73
membrane-bounded organelle (GO:0043227) 0.472MEN1, CDC73
organelle (GO:0043226) 0.42MEN1, CDC73
chromosomal region (GO:0098687) 4.192MEN1, CDC73
organelle part (GO:0044422) 0.792MEN1, CDC73

NET-GE enrichment

Term New enriched termICP valueGenes
nucleoplasm part (GO:0044451) -3.220.033MEN1, CDC73