| Disease ID | Disease name | Source of annotation with CASP8 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 211980 | LUNG CANCER | OMIM | link to OMIM | 17 | RASSF1, PARK2, IRF1, DLEC1, ERBB2, CYP2A6, PPP2R1B, MAP3K8, PIK3CA, BRAF, KRAS, SLC22A18, ERCC6, FASLG, CASP8, MXRA5, EGFR |
| 114550 | HEPATOCELLULAR CARCINOMA | OMIM | link to OMIM | 11 | CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1 |
| 607271 | CASPASE 8 DEFICIENCY | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | CASP8 |
| 114480 | BREAST CANCER | OMIM | link to OMIM | 27 | RB1CC1, ESR1, NBN, PALB2, SLC22A18, BRIP1, BCPR, CASP8, FAM175A, TSG101, CHEK2, BARD1, TP53, AKT1, BRCA1, PIK3CA, PHB, PPM1D, NQO2, ATM, RAD51, BRCA2, CDH1, XRCC3, HMMR, KRAS, RAD54L |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| Legionellosis | hsa05134 | 6.88 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
| Tuberculosis | hsa05152 | 5.17 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| NOD-like receptor signaling pathway | hsa04621 | 6.88 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| p53 signaling pathway | hsa04115 | 6.56 |
| Pathways in cancer | hsa05200 | 3.98 |
| Herpes simplex infection | hsa05168 | 5.08 |
| RIG-I-like receptor signaling pathway | hsa04622 | 6.62 |
| Toxoplasmosis | hsa05145 | 5.71 |
| TNF signaling pathway | hsa04668 | 5.96 |
| Apoptosis | hsa04210 | 6.23 |
| Huntington's disease | hsa05016 | 5.17 |
| Alzheimer's disease | hsa05010 | 5.34 |
| Hepatitis B | hsa05161 | 5.52 |
| Viral myocarditis | hsa05416 | 6.45 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
| Immune System | R-HSA-168256 | 2.37 |
| Apoptotic execution phase | R-HSA-75153 | 7.28 |
| Ligand-dependent caspase activation | R-HSA-140534 | 9.08 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| TRAIL signaling | R-HSA-75158 | 10.18 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 7.73 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 9.28 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| Death Receptor Signalling | R-HSA-73887 | 8.52 |
| Regulation by c-FLIP | R-HSA-3371378 | 9.81 |
| Dimerization of procaspase-8 | R-HSA-69416 | 9.81 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.06 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 9.4 |
| Activation, myristolyation of BID and translocation to mitochondria | R-HSA-75108 | 10.98 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 9.4 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 8.81 |
| Caspase activation via extrinsic apoptotic signalig pathway | R-HSA-5357769 | 8.34 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 7.85 |
| Regulated Necrosis | R-HSA-5218859 | 8.81 |
| MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 9.66 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 6.38 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 8.98 |
| TNF signaling | R-HSA-75893 | 9.08 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| CLEC7A/inflammasome pathway | R-HSA-5660668 | 10.4 |
| CASP8 activity is inhibited | R-HSA-5218900 | 9.81 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 7.31 |
| Apoptosis | R-HSA-109581 | 5.68 |
| FasL/ CD95L signaling | R-HSA-75157 | 10.66 |
| Intrinsic Pathway for Apoptosis | R-HSA-109606 | 7.73 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| cytokine receptor binding | GO:0005126 | 4.14 |
| endopeptidase activity | GO:0004175 | 3.63 |
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| death receptor binding | GO:0005123 | 6.91 |
| enzyme binding | GO:0019899 | 2.27 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| peptidase activity | GO:0008233 | 3.23 |
| cysteine-type peptidase activity | GO:0008234 | 4.51 |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | GO:0097199 | 9.05 |
| death effector domain binding | GO:0035877 | 8.35 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| protein complex binding | GO:0032403 | 3.09 |
| identical protein binding | GO:0042802 | 2.63 |
| hydrolase activity | GO:0016787 | 1.9 |
| tumor necrosis factor receptor superfamily binding | GO:0032813 | 5.89 |
| catalytic activity | GO:0003824 | 1.05 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| tumor necrosis factor receptor binding | GO:0005164 | 6.3 |
| cysteine-type endopeptidase activity involved in apoptotic process | GO:0097153 | 7.03 |
| cysteine-type endopeptidase activity | GO:0004197 | 5.28 |
| scaffold protein binding | GO:0097110 | 5.93 |
| protein binding | GO:0005515 | 0.46 |
| receptor binding | GO:0005102 | 2.43 |
| protein domain specific binding | GO:0019904 | 3.32 |