| Disease ID | Disease name | Source of annotation with NFKB2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS607594 | IMMUNODEFICIENCY, COMMON VARIABLE | ClinVar, OMIM | link to OMIM | 12 | NFKB1, CD19, IL21, CR2, MS4A1, LRBA, NFKB2, CD81, IKZF1, TNFRSF13C, TNFRSF13B, ICOS |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Legionellosis | hsa05134 | 6.88 |
| MAPK signaling pathway | hsa04010 | 4.63 |
| Pathways in cancer | hsa05200 | 3.98 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| Epstein-Barr virus infection | hsa05169 | 4.97 |
| Osteoclast differentiation | hsa04380 | 5.64 |
| NF-kappa B signaling pathway | hsa04064 | 6.21 |
| HTLV-I infection | hsa05166 | 4.59 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.06 |
| Signaling by Interleukins | R-HSA-449147 | 4.71 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 6.51 |
| Immune System | R-HSA-168256 | 2.37 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 6.73 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.34 |
| NIK--noncanonical NF-kB signaling | R-HSA-5676590 | 7.12 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| Disease | R-HSA-1643685 | 3.33 |
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 6.4 |
| IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | R-HSA-5603027 | 9.98 |
| IkBA variant leads to EDA-ID | R-HSA-5603029 | 10.18 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 8.28 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | R-HSA-3134963 | 9.28 |
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 8.4 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 6.56 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 6.68 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | R-HSA-445989 | 8.08 |
| RIP-mediated NFkB activation via ZBP1 | R-HSA-1810476 | 8.59 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 6.94 |
| Diseases of Immune System | R-HSA-5260271 | 8.34 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 6.73 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 6.51 |
| Dectin-1 mediated noncanonical NF-kB signaling | R-HSA-5607761 | 7.1 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 6.72 |
| Interleukin-1 processing | R-HSA-448706 | 10.18 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 6.73 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 6.68 |
| MyD88:Mal cascade initiated on plasma membrane | R-HSA-166058 | 6.56 |
| CLEC7A (Dectin-1) signaling | R-HSA-5607764 | 6.38 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 6.62 |
| GO term | GO ID | GO IC |
|---|---|---|
| RNA polymerase II regulatory region DNA binding | GO:0001012 | 3.36 |
| core promoter proximal region DNA binding | GO:0001159 | 3.82 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GO:0001077 | 4.31 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| sequence-specific DNA binding | GO:0043565 | 2.79 |
| sequence-specific double-stranded DNA binding | GO:1990837 | 3.2 |
| transcription coactivator activity | GO:0003713 | 4.04 |
| transcription cofactor activity | GO:0003712 | 3.44 |
| transcription factor activity, transcription factor binding | GO:0000989 | 3.36 |
| transcription factor activity, protein binding | GO:0000988 | 3.35 |
| core promoter proximal region sequence-specific DNA binding | GO:0000987 | 3.83 |
| double-stranded DNA binding | GO:0003690 | 3.09 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | GO:0000982 | 3.94 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | GO:0000981 | 3.29 |
| regulatory region nucleic acid binding | GO:0001067 | 3.03 |
| transcription regulatory region DNA binding | GO:0044212 | 3.03 |
| transcription factor activity, sequence-specific DNA binding | GO:0003700 | 2.65 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | GO:0001228 | 3.98 |
| transcription regulatory region sequence-specific DNA binding | GO:0000976 | 3.24 |
| RNA polymerase II regulatory region sequence-specific DNA binding | GO:0000977 | 3.37 |
| protein binding | GO:0005515 | 0.46 |
| regulatory region DNA binding | GO:0000975 | 3.03 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | GO:0000978 | 3.88 |
| chromatin binding | GO:0003682 | 3.64 |
| nucleic acid binding transcription factor activity | GO:0001071 | 2.65 |