Disease table of IMMUNODEFICIENCY, COMMON VARIABLE OMIM ID: PS607594

Gene-disease associations table

GeneAssociated with IMMUNODEFICIENCY, COMMON VARIABLE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CR2ClinVar, OMIMHGNC link1q32.22PS607594, 610927
ICOSOMIMHGNC link2q33.21PS607594
LRBAClinVar, OMIM, HUMSAVARHGNC link4q31.31PS607594
CD81OMIMHGNC link11p15.51PS607594
TNFRSF13BClinVar, OMIM, HUMSAVARHGNC link17p11.22609529, PS607594
IL21ClinVar, OMIM, HUMSAVARHGNC link4q271PS607594
NFKB1ClinVar, OMIMHGNC link4q241PS607594
NFKB2ClinVar, OMIMHGNC link10q24.321PS607594
MS4A1OMIMHGNC link11q12.21PS607594
IKZF1ClinVar, OMIMHGNC link7p12.21PS607594
TNFRSF13COMIMHGNC link22q13.21PS607594
CD19OMIMHGNC link16p11.21PS607594

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
4q22IL21, NFKB1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
4q3LRBA, IL21, NFKB1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
112CD81, MS4A1
43LRBA, IL21, NFKB1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
NFKB1YES306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC64TNFRSF13C, NFKB1, IL21, CR2
NFKB2YES7SND1, CCND2, CDK6, CCL21, SELP, EGFR, HIF1A0
IKZF1YES1FGFR40
APEX1NO7CD19, SLC5A5, CCL2, PTH, RELA, CYP11B2, NFKB12NFKB1, CD19
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC63TNFRSF13C, NFKB1, CR2
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12NFKB1, NFKB2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CR2YES3NFKB1, TCF3, RELA1NFKB1
LRBAYES1E2F10
IL21YES2STAT3, NFKB11NFKB1
NFKB1YES30AR, BCL3, TNFAIP3, BTF3, TP53, NFKBIA, ZNF382, HDAC9, FOS, SP1, BCL6, EGR1, NFKB1, HOXA9, TAL1, NR1I2, SRSF1, LYL1, ETV3, HSF1, RELA, PARP1, PIR, EP300, FHL2, NR1H4, NR3C1, RBPJ, APEX1, ZFP361NFKB1
NFKB2YES3SP1, AIP, JUN0
MS4A1YES2IRF4, SPI10
TNFRSF13CYES2NFKB1, RELA1NFKB1
CD19YES2APEX1, PAX50
CCND2NO24NFYA, ABL1, GATA4, FOXL2, TRRAP, RUNX1, NFKB2, SP1, ETV4, BCL6, EGR1, STAT5A, FOXO3, HDAC1, NFYB, NFYC, JUN, RELA, NFKB1, STAT3, MAFB, MYC, MAF, IRF92NFKB1, NFKB2
HIF1ANO20VHL, HIF1A, STAT3, NFKB2, ARNT, HSF4, HIPK2, CITED2, RELA, MITF, LIMD1, EGR1, HDAC7, FOXO4, HIF3A, HSF2, BRCA1, NFKB1, ZFP36, SIRT12NFKB1, NFKB2
EGFRNO30AR, BCL3, WWP1, NR3C2, TFAP2A, PGR, NFKB2, SP1, EGR1, PML, HDAC3, MTA1, BRCA1, WT1, VDR, HOXB7, JUN, TP53, RELA, LRRFIP1, NFKB1, STAT1, STAT3, YY1, YBX1, ESR1, JUNB, PPARG, CREBBP, TSG1012NFKB1, NFKB2
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CR2CD81Yes3IFITM1, CD19, CD81
CR2CD19Yes2IFITM1, CD81
LRBANFKB1No2NOTCH1, VCP
LRBANFKB2No2MOV10, VCP
LRBAIKZF1No1NOTCH1
CD81NFKB1No2RPS3, CD82
CD81NFKB2No3DDX3X, RPL6, RPS13
CD81IKZF1No2NUDT21, RBBP4
CD81CD19Yes5CD9, IFITM1, CD81, CR2, CD82
TNFRSF13BTNFRSF13CNo3TRAF3, TNFSF13B, TRAF2
NFKB1NFKB2Yes28NFKB2, BCL3, VCP, COMMD2, XPO1, BTRC, TNIP2, REL, IKBKG, CHUK, SP1, COMMD1, NFKBIB, DPF2, RELB, NFKBIZ, FBXW11, NFKBIE, TSC22D3, RELA, NKRF, NFKB1, STAT3, NR3C1, TBK1, MEN1, NFKBIA, MAP3K8
NFKB1IKZF1No9NOTCH1, HDAC1, HDAC2, PSMA4, NCOR2, HDAC3, HDAC4, HDAC5, TAT
NFKB1CD19No1CD82

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
LRBANFKB1No-1UBC
LRBANFKB2No-1UBC
LRBAIKZF1No-1UBC
IL21NFKB1No-6STAT3, CSF2, IL2, IL23R, IL12RB1, EPOR
IL21NFKB2No-3IL12RB2, IL12RB1, CSF2
IL21IKZF1No-2NFATC2, IL2
NFKB1NFKB2Yesbinding27TYK2, BCL3, TNFAIP3, IL12A, APP, TP53, IL12RB1, REL, CHUK, MAP3K8, DHX9, AGER, RELB, IL1B, SAA1, CSF2, BTRC, NFKBIE, IKBKB, JAK2, RELA, HMGB1, UNC5CL, IL18, FBXW11, UBC, NFKBIB
NFKB1IKZF1No-7IL2, GTF2B, HDAC1, HDAC2, NOTCH1, UBC, MYC
NFKB2IKZF1No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
NFKB1NFKB2YesTNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2);NFKB1-NFKB2-REL-RELA-RELB complex;TNF-alpha/NF-kappa B signaling complex 5;NFKB1-NFKB2-RELA-RELB complex;TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I);CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex38COPB2, CUL1, TNIP2, REL, IKBKG, POLR2H, RELB, CD3EAP, MTIF2, NFKBIB, SPAG9, GLG1, RPL6, CHUK, KPNA3, LRPPRC, FBXW11, POLR1E, RASAL2, NFKBIE, IKBKB, TNIP1, MCC, RELA, POLR1A, RPL30, GTF2I, IQGAP2, DDX3X, SKP1, PDCD2, POLR2L, NFKBIA, KPNA2, POLR1B, RPS13, MAP3K8, POLR1D

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Primary immunodeficiencyhsa053407.524TNFRSF13C, CD19, TNFRSF13B, ICOS
B cell receptor signaling pathwayhsa046626.524NFKB1, CR2, CD81, CD19
Epstein-Barr virus infectionhsa051694.974NFKB1, NFKB2, CR2, CD19
Intestinal immune network for IgA productionhsa046726.793TNFRSF13C, TNFRSF13B, ICOS
NF-kappa B signaling pathwayhsa040646.213TNFRSF13C, NFKB1, NFKB2
Hematopoietic cell lineagehsa046406.183MS4A1, CD19, CR2
HTLV-I infectionhsa051664.593TNFRSF13C, NFKB1, NFKB2
Cytokine-cytokine receptor interactionhsa040604.673TNFRSF13C, TNFRSF13B, IL21
Legionellosishsa051346.882NFKB1, NFKB2
MAPK signaling pathwayhsa040104.632NFKB1, NFKB2
Inflammatory bowel disease (IBD)hsa053216.432NFKB1, IL21
Pathways in cancerhsa052003.982NFKB1, NFKB2
Viral carcinogenesishsa052035.082NFKB1, NFKB2
T cell receptor signaling pathwayhsa046606.012NFKB1, ICOS
Osteoclast differentiationhsa043805.642NFKB1, NFKB2
Hepatitis Chsa051605.682NFKB1, CD81
PI3K-Akt signaling pathwayhsa041514.212NFKB1, CD19

NET-GE enrichment

Term New enriched termICP valueGenes
Immune diseasesNEW4.470.0NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, TNFRSF13B
Human DiseasesNEW1.540.035TNFRSF13B, NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, NFKB2
Hematopoietic cell lineage (hsa04640) -6.180.022MS4A1, CD19, CD81, CR2
Environmental Information ProcessingNEW1.710.021NFKB2, NFKB1, MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, IKZF1, TNFRSF13B
Infectious diseases: ViralNEW3.290.013CD81, CR2, CD19, TNFRSF13C, NFKB1, NFKB2
Intestinal immune network for IgA production (hsa04672) -6.790.006TNFRSF13C, TNFRSF13B, ICOS
B cell receptor signaling pathway (hsa04662) -6.520.001NFKB1, CR2, CD81, CD19
Epstein-Barr virus infection (hsa05169) -4.970.014NFKB1, NFKB2, CR2, CD19
Immune systemNEW2.920.0TNFRSF13B, NFKB1, MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, NFKB2
Primary immunodeficiency (hsa05340) -7.520.0TNFRSF13C, CD19, TNFRSF13B, ICOS
NF-kappa B signaling pathway (hsa04064) -6.210.004TNFRSF13C, NFKB1, NFKB2, CR2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.377ICOS, CD81, TNFRSF13B, CD19, TNFRSF13C, NFKB1, NFKB2
Cytokine Signaling in Immune systemR-HSA-12802153.744TNFRSF13C, NFKB1, TNFRSF13B, NFKB2
Adaptive Immune SystemR-HSA-12802183.194NFKB1, ICOS, CD81, CD19
TNFR2 non-canonical NF-kB pathwayR-HSA-56685416.43TNFRSF13C, TNFRSF13B, NFKB2
Innate Immune SystemR-HSA-1682493.173NFKB1, CD19, NFKB2
DiseaseR-HSA-16436853.333NFKB1, CD19, NFKB2
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.472NFKB1, NFKB2
TRAF6 mediated NF-kB activationR-HSA-9335428.42NFKB1, NFKB2
Signaling by InterleukinsR-HSA-4491474.712NFKB1, NFKB2
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.512NFKB1, NFKB2
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.112NFKB1, NFKB2
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622NFKB1, CD19
MyD88 cascade initiated on plasma membraneR-HSA-9758716.732NFKB1, NFKB2
Diseases associated with the TLR signaling cascadeR-HSA-56023588.342NFKB1, NFKB2
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.72NFKB1, NFKB2
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-31349639.282NFKB1, NFKB2
Signalling by NGFR-HSA-1665204.232NFKB1, CD19
IkBA variant leads to EDA-IDR-HSA-560302910.182NFKB1, NFKB2
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.472NFKB1, NFKB2
Toll-Like Receptors CascadesR-HSA-1688985.912NFKB1, NFKB2
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592NFKB1, CD19
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.472NFKB1, NFKB2
ZBP1(DAI) mediated induction of type I IFNsR-HSA-16063228.282NFKB1, NFKB2
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellR-HSA-1989334.72CD19, CD81
C-type lectin receptors (CLRs)R-HSA-56214816.062NFKB1, NFKB2
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.562NFKB1, NFKB2
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032NFKB1, CD19
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.682NFKB1, NFKB2
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.082NFKB1, NFKB2
RIP-mediated NFkB activation via ZBP1R-HSA-18104768.592NFKB1, NFKB2
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.942NFKB1, NFKB2
Diseases of Immune SystemR-HSA-52602718.342NFKB1, NFKB2
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)R-HSA-56030279.982NFKB1, NFKB2
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.512NFKB1, NFKB2
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.732NFKB1, NFKB2
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.722NFKB1, NFKB2
Interleukin-1 processingR-HSA-44870610.182NFKB1, NFKB2
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.732NFKB1, NFKB2
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.682NFKB1, NFKB2
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.562NFKB1, NFKB2
CLEC7A (Dectin-1) signalingR-HSA-56077646.382NFKB1, NFKB2
Activated TLR4 signallingR-HSA-1660546.272NFKB1, NFKB2
Signal TransductionR-HSA-1625821.782NFKB1, CD19
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.622NFKB1, NFKB2

NET-GE enrichment

Term New enriched termICP valueGenes
TRAF6 mediated NF-kB activation (R-HSA-933542) -8.40.017NFKB1, NFKB2
TNFR2 non-canonical NF-kB pathway (R-HSA-5668541) -6.40.005TNFRSF13C, TNFRSF13B, NFKB2
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) (R-HSA-5603027) -9.980.002NFKB1, NFKB2
IkBA variant leads to EDA-ID (R-HSA-5603029) -10.180.001NFKB1, NFKB2
Interleukin-1 processing (R-HSA-448706) -10.180.001NFKB1, NFKB2
Immune System (R-HSA-168256) -2.370.001ICOS, CD81, TNFRSF13B, CD19, TNFRSF13C, NFKB1, NFKB2
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (R-HSA-445989) -8.080.027NFKB1, NFKB2
Diseases associated with the TLR signaling cascade (R-HSA-5602358) -8.340.019NFKB1, NFKB2
RIP-mediated NFkB activation via ZBP1 (R-HSA-1810476) -8.590.013NFKB1, NFKB2
Diseases of Immune System (R-HSA-5260271) -8.340.019NFKB1, NFKB2
ZBP1(DAI) mediated induction of type I IFNs (R-HSA-1606322) -8.280.02NFKB1, NFKB2
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (R-HSA-3134963) -9.280.024NFKB1, NFKB2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189NFKB2, MS4A1, IL21, CD81, CD19, CR2, NFKB1, IKZF1, TNFRSF13B
protein binding (GO:0005515) 0.469NFKB2, MS4A1, IL21, CD81, CD19, CR2, NFKB1, IKZF1, TNFRSF13B
organic cyclic compound binding (GO:0097159) 1.054IKZF1, NFKB1, NFKB2, CR2
macromolecular complex binding (GO:0044877) 2.614MS4A1, NFKB1, NFKB2, CD81
heterocyclic compound binding (GO:1901363) 1.064IKZF1, NFKB1, NFKB2, CR2
nucleic acid binding (GO:0003676) 1.444IKZF1, NFKB1, NFKB2, CR2
DNA binding (GO:0003677) 1.924IKZF1, NFKB1, NFKB2, CR2
transcription regulatory region DNA binding (GO:0044212) 3.033NFKB1, IKZF1, NFKB2
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653NFKB1, IKZF1, NFKB2
regulatory region nucleic acid binding (GO:0001067) 3.033NFKB1, IKZF1, NFKB2
nucleic acid binding transcription factor activity (GO:0001071) 2.653NFKB1, IKZF1, NFKB2
regulatory region DNA binding (GO:0000975) 3.033NFKB1, IKZF1, NFKB2
receptor binding (GO:0005102) 2.433MS4A1, CD81, IL21
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372NFKB1, NFKB2
sequence-specific DNA binding (GO:0043565) 2.792NFKB1, NFKB2
MHC class II protein complex binding (GO:0023026) 6.972MS4A1, CD81
sequence-specific double-stranded DNA binding (GO:1990837) 3.22NFKB1, NFKB2
antigen binding (GO:0003823) 5.022MS4A1, CD81
growth factor receptor binding (GO:0070851) 4.872MS4A1, IL21
chromatin binding (GO:0003682) 3.642NFKB1, NFKB2
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362NFKB1, NFKB2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982NFKB1, NFKB2
MHC protein complex binding (GO:0023023) 6.792MS4A1, CD81
molecular transducer activity (GO:0060089) 2.322TNFRSF13B, CR2
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242NFKB1, NFKB2
receptor activity (GO:0004872) 2.322TNFRSF13B, CR2
signal transducer activity (GO:0004871) 2.282CD19, CR2
protein complex binding (GO:0032403) 3.092MS4A1, CD81
double-stranded DNA binding (GO:0003690) 3.092NFKB1, NFKB2
protein homodimerization activity (GO:0042803) 3.162NFKB1, CR2
protein dimerization activity (GO:0046983) 2.722NFKB1, CR2
identical protein binding (GO:0042802) 2.632NFKB1, CR2
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292NFKB1, NFKB2

NET-GE enrichment

Term New enriched termICP valueGenes
MHC protein complex binding (GO:0023023) -6.790.002MS4A1, CD81
receptor binding (GO:0005102) -2.430.001NFKB1, MS4A1, IL21, CD81, CD19, CR2, ICOS, IKZF1, NFKB2
signaling receptor activity (GO:0038023) NEW2.490.028NFKB1, IL21, CD81, CD19, CR2, ICOS, NFKB2
MHC class II protein complex binding (GO:0023026) -6.970.002MS4A1, CD81
receptor activity (GO:0004872) -2.320.008TNFRSF13B, NFKB1, IL21, CD81, CD19, CR2, ICOS, NFKB2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to stimulus (GO:0050896) 1.2210TNFRSF13B, NFKB1, MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, NFKB2
regulation of cellular process (GO:0050794) 0.510NFKB2, NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, IKZF1, TNFRSF13B
immune system process (GO:0002376) 2.2910NFKB2, MS4A1, IL21, ICOS, CD19, TNFRSF13C, CR2, NFKB1, IKZF1, TNFRSF13B
biological regulation (GO:0065007) 0.3910NFKB2, NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, IKZF1, TNFRSF13B
regulation of biological process (GO:0050789) 0.4510NFKB2, NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, TNFRSF13B, ICOS, IKZF1
single-organism process (GO:0044699) 0.4810NFKB2, NFKB1, MS4A1, IL21, CD81, CD19, CR2, ICOS, IKZF1, TNFRSF13B
positive regulation of biological process (GO:0048518) 1.29NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, IKZF1, NFKB2
cellular process (GO:0009987) 0.269TNFRSF13B, MS4A1, CD81, IL21, IKZF1, CD19, CR2, NFKB1, NFKB2
single-organism cellular process (GO:0044763) 0.659NFKB2, MS4A1, IL21, CD81, CD19, CR2, NFKB1, IKZF1, TNFRSF13B
regulation of immune system process (GO:0002682) 2.58NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, TNFRSF13B
signal transduction (GO:0007165) 1.288CD81, IL21, TNFRSF13B, CD19, TNFRSF13C, CR2, NFKB1, NFKB2
immune response (GO:0006955) 2.868ICOS, MS4A1, IL21, TNFRSF13B, TNFRSF13C, CR2, NFKB1, NFKB2
organic substance metabolic process (GO:0071704) 0.637CD81, IL21, IKZF1, CD19, CR2, NFKB1, NFKB2
positive regulation of immune system process (GO:0002684) 2.967NFKB1, IL21, CD81, CD19, TNFRSF13C, ICOS, CR2
metabolic process (GO:0008152) 0.587CD81, IL21, IKZF1, CD19, CR2, NFKB1, NFKB2
positive regulation of cellular process (GO:0048522) 1.37ICOS, CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
primary metabolic process (GO:0044238) 0.696IL21, IKZF1, CD19, CR2, NFKB1, NFKB2
regulation of immune response (GO:0050776) 2.986IL21, CD81, CD19, TNFRSF13C, NFKB1, CR2
positive regulation of metabolic process (GO:0009893) 1.746CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
regulation of metabolic process (GO:0019222) 1.026CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
positive regulation of biosynthetic process (GO:0009891) 2.296CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
regulation of macromolecule metabolic process (GO:0060255) 1.086CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
regulation of response to stimulus (GO:0048583) 1.546IL21, CD81, CD19, TNFRSF13C, NFKB1, CR2
positive regulation of cellular metabolic process (GO:0031325) 1.816CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
positive regulation of response to stimulus (GO:0048584) 2.186IL21, CD81, CD19, TNFRSF13C, NFKB1, CR2
regulation of biosynthetic process (GO:0009889) 1.376CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
positive regulation of macromolecule metabolic process (GO:0010604) 1.816CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
cellular metabolic process (GO:0044237) 0.696CD81, IL21, IKZF1, CD19, NFKB1, NFKB2
macromolecule metabolic process (GO:0043170) 0.836CD81, IL21, IKZF1, CR2, NFKB1, NFKB2
regulation of cellular metabolic process (GO:0031323) 1.076CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.396CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
regulation of macromolecule biosynthetic process (GO:0010556) 1.436CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
positive regulation of cellular biosynthetic process (GO:0031328) 2.36CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
cell surface receptor signaling pathway (GO:0007166) 2.096CD81, CR2, CD19, TNFRSF13C, NFKB1, TNFRSF13B
regulation of cellular biosynthetic process (GO:0031326) 1.386CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
regulation of primary metabolic process (GO:0080090) 1.086CD81, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
regulation of lymphocyte activation (GO:0051249) 3.735TNFRSF13C, TNFRSF13B, ICOS, IL21, CD81
cellular macromolecule metabolic process (GO:0044260) 0.935IL21, IKZF1, NFKB1, NFKB2, CD81
regulation of cell activation (GO:0050865) 3.535TNFRSF13C, TNFRSF13B, ICOS, CD81, IL21
cellular developmental process (GO:0048869) 1.825IL21, NFKB2, IKZF1, TNFRSF13B, CR2
positive regulation of immune response (GO:0050778) 3.45TNFRSF13C, NFKB1, IL21, CR2, CD19
regulation of leukocyte activation (GO:0002694) 3.65TNFRSF13C, TNFRSF13B, ICOS, CD81, IL21
response to stress (GO:0006950) 1.85NFKB2, NFKB1, CD81, CR2, CD19
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564IKZF1, NFKB1, NFKB2, CD81
regulation of B cell activation (GO:0050864) 4.924TNFRSF13C, TNFRSF13B, IL21, CD81
positive regulation of cell activation (GO:0050867) 3.974TNFRSF13C, ICOS, IL21, CD81
regulation of RNA biosynthetic process (GO:2001141) 1.554IKZF1, NFKB1, NFKB2, CD81
regulation of B cell proliferation (GO:0030888) 5.694TNFRSF13C, TNFRSF13B, IL21, CD81
positive regulation of gene expression (GO:0010628) 2.354IKZF1, NFKB1, NFKB2, CD81
regulation of mononuclear cell proliferation (GO:0032944) 4.454TNFRSF13C, TNFRSF13B, IL21, CD81
regulation of signaling (GO:0023051) 1.724NFKB1, IL21, CD81, CD19
regulation of cell communication (GO:0010646) 1.734NFKB1, IL21, CD81, CD19
regulation of cytokine production (GO:0001817) 3.44TNFRSF13C, NFKB1, NFKB2, IL21
regulation of signal transduction (GO:0009966) 1.844NFKB1, IL21, CD81, CD19
positive regulation of multicellular organismal process (GO:0051240) 2.494TNFRSF13C, NFKB1, NFKB2, IL21
regulation of protein metabolic process (GO:0051246) 1.934TNFRSF13C, NFKB1, CD81, IL21
regulation of leukocyte proliferation (GO:0070663) 4.44TNFRSF13C, TNFRSF13B, IL21, CD81
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244IKZF1, NFKB1, NFKB2, CD81
positive regulation of transcription, DNA-templated (GO:0045893) 2.564IKZF1, NFKB1, NFKB2, CD81
negative regulation of biological process (GO:0048519) 1.334TNFRSF13B, NFKB1, NFKB2, IKZF1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464IKZF1, NFKB1, NFKB2, CD81
regulation of gene expression (GO:0010468) 1.374IKZF1, NFKB1, NFKB2, CD81
regulation of cell proliferation (GO:0042127) 2.414TNFRSF13C, TNFRSF13B, CD81, IL21
cell differentiation (GO:0030154) 2.144NFKB2, TNFRSF13B, IKZF1, CR2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354IKZF1, NFKB1, NFKB2, CD81
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434IKZF1, NFKB1, NFKB2, CD81
regulation of nucleic acid-templated transcription (GO:1903506) 1.554IKZF1, NFKB1, NFKB2, CD81
defense response (GO:0006952) 2.784NFKB1, NFKB2, CR2, CD19
cell activation (GO:0001775) 3.474IKZF1, MS4A1, NFKB2, CR2
regulation of nitrogen compound metabolic process (GO:0051171) 1.364IKZF1, NFKB1, NFKB2, CD81
regulation of multicellular organismal process (GO:0051239) 1.874TNFRSF13C, NFKB1, NFKB2, IL21
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294IKZF1, NFKB1, NFKB2, CD81
regulation of biological quality (GO:0065008) 1.684TNFRSF13C, NFKB1, TNFRSF13B, CD81
positive regulation of lymphocyte activation (GO:0051251) 4.074TNFRSF13C, ICOS, IL21, CD81
regulation of RNA metabolic process (GO:0051252) 1.524IKZF1, NFKB1, NFKB2, CD81
regulation of lymphocyte proliferation (GO:0050670) 4.464TNFRSF13C, TNFRSF13B, IL21, CD81
positive regulation of RNA metabolic process (GO:0051254) 2.514IKZF1, NFKB1, NFKB2, CD81
positive regulation of RNA biosynthetic process (GO:1902680) 2.544IKZF1, NFKB1, NFKB2, CD81
regulation of transcription, DNA-templated (GO:0006355) 1.564IKZF1, NFKB1, NFKB2, CD81
positive regulation of leukocyte activation (GO:0002696) 4.04TNFRSF13C, ICOS, IL21, CD81
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.814IKZF1, NFKB1, NFKB2, CD81
negative regulation of cellular process (GO:0048523) 1.414IKZF1, NFKB1, NFKB2, TNFRSF13B
positive regulation of cytokine production (GO:0001819) 3.824TNFRSF13C, NFKB1, NFKB2, IL21
developmental process (GO:0032502) 1.363IKZF1, NFKB2, IL21
negative regulation of metabolic process (GO:0009892) 1.933NFKB1, IKZF1, NFKB2
RNA biosynthetic process (GO:0032774) 1.843NFKB1, IKZF1, NFKB2
negative regulation of biosynthetic process (GO:0009890) 2.473NFKB1, IKZF1, NFKB2
negative regulation of cellular biosynthetic process (GO:0031327) 2.493NFKB1, IKZF1, NFKB2
phosphorylation (GO:0016310) 2.633NFKB1, CD19, IL21
regulation of cell adhesion (GO:0030155) 3.273TNFRSF13C, ICOS, IL21
negative regulation of cellular metabolic process (GO:0031324) 2.013NFKB1, IKZF1, NFKB2
regulation of T cell activation (GO:0050863) 4.053TNFRSF13C, ICOS, IL21
positive regulation of protein metabolic process (GO:0051247) 2.433TNFRSF13C, CD81, IL21
positive regulation of signaling (GO:0023056) 2.413NFKB1, CD81, IL21
regulation of cell-cell adhesion (GO:0022407) 3.793TNFRSF13C, ICOS, IL21
negative regulation of gene expression (GO:0010629) 2.483NFKB1, IKZF1, NFKB2
nitrogen compound metabolic process (GO:0006807) 1.133NFKB1, IKZF1, NFKB2
regulation of cytokine biosynthetic process (GO:0042035) 5.153TNFRSF13C, NFKB1, IL21
cellular macromolecule biosynthetic process (GO:0034645) 1.663NFKB1, IKZF1, NFKB2
organic substance biosynthetic process (GO:1901576) 1.343NFKB1, IKZF1, NFKB2
intracellular signal transduction (GO:0035556) 2.393NFKB1, CD19, NFKB2
regulation of cellular protein metabolic process (GO:0032268) 1.993NFKB1, CD81, IL21
organic cyclic compound biosynthetic process (GO:1901362) 1.663NFKB1, IKZF1, NFKB2
positive regulation of cell communication (GO:0010647) 2.413NFKB1, IL21, CD81
organic cyclic compound metabolic process (GO:1901360) 1.263NFKB1, IKZF1, NFKB2
positive regulation of cell-cell adhesion (GO:0022409) 4.233TNFRSF13C, ICOS, IL21
nucleobase-containing compound metabolic process (GO:0006139) 1.353NFKB1, IKZF1, NFKB2
single-organism metabolic process (GO:0044710) 1.633NFKB1, CD19, CD81
negative regulation of macromolecule metabolic process (GO:0010605) 2.013NFKB1, IKZF1, NFKB2
immune response-regulating signaling pathway (GO:0002764) 3.723NFKB1, CD19, CR2
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.123NFKB1, IKZF1, NFKB2
positive regulation of signal transduction (GO:0009967) 2.53NFKB1, CD81, IL21
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63NFKB1, IKZF1, NFKB2
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.353TNFRSF13C, ICOS, IL21
lymphocyte activation (GO:0046649) 3.963MS4A1, IKZF1, CR2
positive regulation of leukocyte proliferation (GO:0070665) 4.793TNFRSF13C, CD81, IL21
nucleic acid-templated transcription (GO:0097659) 1.913NFKB1, IKZF1, NFKB2
positive regulation of molecular function (GO:0044093) 2.233NFKB1, NFKB2, CD81
regulation of molecular function (GO:0065009) 1.783NFKB1, NFKB2, CD81
multi-organism process (GO:0051704) 2.653NFKB1, CR2, CD81
heterocycle biosynthetic process (GO:0018130) 1.73NFKB1, IKZF1, NFKB2
positive regulation of cell proliferation (GO:0008284) 3.013TNFRSF13C, IL21, CD81
nucleic acid metabolic process (GO:0090304) 1.463NFKB1, IKZF1, NFKB2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553NFKB1, IKZF1, NFKB2
positive regulation of B cell proliferation (GO:0030890) 6.093TNFRSF13C, IL21, CD81
cell proliferation (GO:0008283) 3.233MS4A1, CR2, CD81
innate immune response (GO:0045087) 3.553NFKB1, NFKB2, CR2
cellular aromatic compound metabolic process (GO:0006725) 1.33NFKB1, IKZF1, NFKB2
positive regulation of T cell activation (GO:0050870) 4.393TNFRSF13C, ICOS, IL21
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713NFKB1, IKZF1, NFKB2
single-organism developmental process (GO:0044767) 1.493IKZF1, NFKB2, IL21
biosynthetic process (GO:0009058) 1.323NFKB1, IKZF1, NFKB2
immune response-activating signal transduction (GO:0002757) 3.83NFKB1, CD19, CR2
negative regulation of transcription, DNA-templated (GO:0045892) 2.753NFKB1, IKZF1, NFKB2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473NFKB1, IKZF1, NFKB2
leukocyte activation (GO:0045321) 3.763MS4A1, IKZF1, CR2
response to chemical (GO:0042221) 1.983NFKB1, NFKB2, CD81
cellular nitrogen compound metabolic process (GO:0034641) 1.223NFKB1, IKZF1, NFKB2
regulation of intracellular signal transduction (GO:1902531) 2.313CD19, CD81, IL21
response to organic substance (GO:0010033) 2.23NFKB1, NFKB2, CD81
heterocycle metabolic process (GO:0046483) 1.313NFKB1, IKZF1, NFKB2
RNA metabolic process (GO:0016070) 1.593NFKB1, IKZF1, NFKB2
negative regulation of RNA biosynthetic process (GO:1902679) 2.73NFKB1, IKZF1, NFKB2
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.063NFKB1, CD19, CR2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593NFKB1, IKZF1, NFKB2
cellular biosynthetic process (GO:0044249) 1.373NFKB1, IKZF1, NFKB2
protein metabolic process (GO:0019538) 1.453NFKB1, IL21, CR2
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.963NFKB1, CD19, CR2
negative regulation of RNA metabolic process (GO:0051253) 2.663NFKB1, IKZF1, NFKB2
positive regulation of cell adhesion (GO:0045785) 3.793TNFRSF13C, ICOS, IL21
positive regulation of lymphocyte proliferation (GO:0050671) 4.853TNFRSF13C, CD81, IL21
positive regulation of B cell activation (GO:0050871) 5.273TNFRSF13C, CD81, IL21
phosphate-containing compound metabolic process (GO:0006796) 2.163NFKB1, CD19, IL21
macromolecule biosynthetic process (GO:0009059) 1.613NFKB1, IKZF1, NFKB2
positive regulation of mononuclear cell proliferation (GO:0032946) 4.843TNFRSF13C, IL21, CD81
transcription, DNA-templated (GO:0006351) 1.913NFKB1, IKZF1, NFKB2
activation of immune response (GO:0002253) 3.673NFKB1, CD19, CR2
phosphorus metabolic process (GO:0006793) 2.153NFKB1, CD19, IL21
aromatic compound biosynthetic process (GO:0019438) 1.73NFKB1, IKZF1, NFKB2
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013TNFRSF13C, ICOS, IL21
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723NFKB1, IKZF1, NFKB2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533NFKB1, IKZF1, NFKB2
adaptive immune response (GO:0002250) 4.433TNFRSF13C, TNFRSF13B, NFKB2
regulation of phosphate metabolic process (GO:0019220) 2.352CD81, IL21
cytokine-mediated signaling pathway (GO:0019221) 3.62TNFRSF13C, TNFRSF13B
positive regulation of defense response (GO:0031349) 3.832NFKB1, IL21
cellular component organization or biogenesis (GO:0071840) 1.222IKZF1, NFKB2
cellular response to stimulus (GO:0051716) 1.972NFKB1, CD81
response to external biotic stimulus (GO:0043207) 3.132NFKB1, NFKB2
lymphocyte homeostasis (GO:0002260) 5.862TNFRSF13C, TNFRSF13B
regulation of inflammatory response (GO:0050727) 4.032NFKB1, IL21
interspecies interaction between organisms (GO:0044419) 3.082CD81, CR2
positive regulation of interferon-gamma production (GO:0032729) 5.592TNFRSF13C, IL21
T cell costimulation (GO:0031295) 5.352TNFRSF13C, ICOS
lymphocyte costimulation (GO:0031294) 5.332TNFRSF13C, ICOS
regulation of T cell proliferation (GO:0042129) 4.742TNFRSF13C, IL21
interaction with host (GO:0051701) 4.862CR2, CD81
regulation of phosphorylation (GO:0042325) 2.52IL21, CD81
positive regulation of phosphorylation (GO:0042327) 2.92IL21, CD81
response to biotic stimulus (GO:0009607) 3.092NFKB1, NFKB2
homeostasis of number of cells (GO:0048872) 4.982TNFRSF13C, TNFRSF13B
response to external stimulus (GO:0009605) 2.552NFKB1, NFKB2
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622CD81, IL21
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352IL21, CD81
viral entry into host cell (GO:0046718) 5.352CR2, CD81
NIK/NF-kappaB signaling (GO:0038061) 5.542NFKB1, NFKB2
regulation of interferon-gamma production (GO:0032649) 5.212TNFRSF13C, IL21
mononuclear cell proliferation (GO:0032943) 5.322MS4A1, CR2
lymphocyte proliferation (GO:0046651) 5.352MS4A1, CR2
response to lipopolysaccharide (GO:0032496) 4.032NFKB1, NFKB2
positive regulation of cytokine biosynthetic process (GO:0042108) 5.652TNFRSF13C, IL21
cellular protein metabolic process (GO:0044267) 1.632NFKB1, IL21
cellular component organization (GO:0016043) 1.242IKZF1, NFKB2
regulation of defense response (GO:0031347) 3.112NFKB1, IL21
transcription from RNA polymerase II promoter (GO:0006366) 3.382NFKB1, NFKB2
response to cytokine (GO:0034097) 3.842NFKB1, NFKB2
regulation of catalytic activity (GO:0050790) 1.972NFKB1, CD81
leukocyte homeostasis (GO:0001776) 5.722TNFRSF13C, TNFRSF13B
positive regulation of type I interferon production (GO:0032481) 5.482NFKB1, NFKB2
protein modification process (GO:0036211) 1.792NFKB1, IL21
inflammatory response (GO:0006954) 3.642NFKB1, NFKB2
positive regulation of intracellular signal transduction (GO:1902533) 2.952IL21, CD81
humoral immune response (GO:0006959) 4.592MS4A1, CR2
leukocyte differentiation (GO:0002521) 4.132IKZF1, CR2
regulation of response to stress (GO:0080134) 2.532NFKB1, IL21
positive regulation of protein modification process (GO:0031401) 2.72IL21, CD81
macromolecule modification (GO:0043412) 1.732NFKB1, IL21
regulation of response to external stimulus (GO:0032101) 3.062NFKB1, IL21
tumor necrosis factor-mediated signaling pathway (GO:0033209) 4.962TNFRSF13C, TNFRSF13B
entry into host cell (GO:0030260) 5.32CD81, CR2
cellular response to chemical stimulus (GO:0070887) 2.572NFKB1, CD81
response to endogenous stimulus (GO:0009719) 2.792NFKB1, CD81
positive regulation of interferon-gamma biosynthetic process (GO:0045078) 7.242TNFRSF13C, IL21
positive regulation of phosphorus metabolic process (GO:0010562) 2.782CD81, IL21
regulation of interferon-gamma biosynthetic process (GO:0045072) 6.962TNFRSF13C, IL21
positive regulation of cellular protein metabolic process (GO:0032270) 2.492IL21, CD81
regulation of protein modification process (GO:0031399) 2.322CD81, IL21
B cell homeostasis (GO:0001782) 6.642TNFRSF13C, TNFRSF13B
biological adhesion (GO:0022610) 2.812ICOS, CD81
cellular response to endogenous stimulus (GO:0071495) 3.332NFKB1, CD81
regulation of localization (GO:0032879) 1.942NFKB1, CD81
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852NFKB1, NFKB2
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292NFKB1, NFKB2
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832NFKB1, NFKB2
I-kappaB kinase/NF-kappaB signaling (GO:0007249) 5.672NFKB1, NFKB2
entry into other organism involved in symbiotic interaction (GO:0051828) 5.32CD81, CR2
response to molecule of bacterial origin (GO:0002237) 3.992NFKB1, NFKB2
lymphocyte differentiation (GO:0030098) 4.492IKZF1, CR2
regulation of type I interferon production (GO:0032479) 5.032NFKB1, NFKB2
B cell activation (GO:0042113) 4.842MS4A1, CR2
homeostatic process (GO:0042592) 2.612TNFRSF13C, TNFRSF13B
response to lipid (GO:0033993) 3.112NFKB1, NFKB2
leukocyte proliferation (GO:0070661) 5.252MS4A1, CR2
cellular response to organic substance (GO:0071310) 2.782NFKB1, CD81
antigen receptor-mediated signaling pathway (GO:0050851) 4.432NFKB1, CD19
protein phosphorylation (GO:0006468) 2.892NFKB1, IL21
positive regulation of innate immune response (GO:0045089) 4.222NFKB1, IL21
regulation of innate immune response (GO:0045088) 3.862NFKB1, IL21
positive regulation of phosphate metabolic process (GO:0045937) 2.782CD81, IL21
regulation of lipid metabolic process (GO:0019216) 4.082NFKB1, CD81
B cell proliferation (GO:0042100) 6.122MS4A1, CR2
cellular protein modification process (GO:0006464) 1.792NFKB1, IL21
positive regulation of T cell proliferation (GO:0042102) 5.162TNFRSF13C, IL21
regulation of phosphorus metabolic process (GO:0051174) 2.352CD81, IL21
multi-organism cellular process (GO:0044764) 3.142CD81, CR2
response to oxygen-containing compound (GO:1901700) 2.572NFKB1, NFKB2
anatomical structure development (GO:0048856) 1.582IKZF1, NFKB2
entry into host (GO:0044409) 5.32CD81, CR2
viral process (GO:0016032) 3.152CR2, CD81
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152CR2, CD81
entry into cell of other organism involved in symbiotic interaction (GO:0051806) 5.32CD81, CR2
regulation of protein phosphorylation (GO:0001932) 2.572CD81, IL21
positive regulation of protein phosphorylation (GO:0001934) 2.952CD81, IL21

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of cell activation (GO:0050865) -3.530.003NFKB2, IL21, ICOS, CD19, TNFRSF13C, CR2, NFKB1, IKZF1, TNFRSF13B
regulation of B cell activation (GO:0050864) -4.920.014TNFRSF13C, TNFRSF13B, ICOS, IL21
positive regulation of cell activation (GO:0050867) -3.970.001ICOS, IL21, IKZF1, TNFRSF13C, CR2, NFKB1, NFKB2
positive regulation of response to stimulus (GO:0048584) -2.180.014IL21, CD81, CD19, TNFRSF13C, CR2, NFKB1, NFKB2
regulation of B cell proliferation (GO:0030888) -5.690.002TNFRSF13C, TNFRSF13B, ICOS, IL21
regulation of T cell activation (GO:0050863) -4.050.011IL21, IKZF1, CD19, TNFRSF13C, CR2, ICOS, NFKB2
positive regulation of defense response (GO:0031349) -3.830.041NFKB1, NFKB2, CD19, CR2, IL21
mononuclear cell proliferation (GO:0032943) -5.320.008MS4A1, ICOS, CR2, CD19
regulation of cytokine biosynthetic process (GO:0042035) -5.150.014TNFRSF13C, NFKB1, IL21, CR2
lymphocyte proliferation (GO:0046651) -5.350.008MS4A1, ICOS, CR2, CD19
activation of immune response (GO:0002253) -3.670.027MS4A1, CD81, CR2, CD19, NFKB1, NFKB2
regulation of lymphocyte activation (GO:0051249) -3.730.0ICOS, IL21, IKZF1, CD19, TNFRSF13C, CR2, TNFRSF13B, NFKB1, NFKB2
positive regulation of interferon-gamma biosynthetic process (GO:0045078) -7.240.014TNFRSF13C, IL21
B cell differentiation (GO:0030183) NEW5.240.0CR2, NFKB1, IKZF1, CD81, CD19
regulation of interferon-gamma biosynthetic process (GO:0045072) -6.960.025TNFRSF13C, IL21
leukocyte proliferation (GO:0070661) -5.250.011MS4A1, CD19, ICOS, CR2
positive regulation of immune system process (GO:0002684) -2.960.0NFKB1, MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, IKZF1, NFKB2
regulation of immune system process (GO:0002682) -2.50.0NFKB2, NFKB1, IL21, CD81, CD19, TNFRSF13C, CR2, TNFRSF13B, ICOS, IKZF1
negative regulation of immune system process (GO:0002683) NEW3.850.006ICOS, TNFRSF13B, CD19, CR2, NFKB1, NFKB2
regulation of innate immune response (GO:0045088) -3.860.049CR2, NFKB1, NFKB2, IL21, CD19
immune response-activating signal transduction (GO:0002757) -3.80.013MS4A1, CD81, CR2, CD19, NFKB1, NFKB2
B cell proliferation (GO:0042100) -6.120.015MS4A1, CD19, CR2
positive regulation of T cell activation (GO:0050870) -4.390.023TNFRSF13C, IKZF1, ICOS, NFKB2, IL21
B cell activation (GO:0042113) -4.840.038MS4A1, CD81, ICOS, CD19, CR2, NFKB1, IKZF1
cell activation (GO:0001775) -3.470.0NFKB1, MS4A1, IL21, CD81, CD19, CR2, ICOS, IKZF1, NFKB2
lymphocyte activation (GO:0046649) -3.960.0NFKB1, MS4A1, IL21, CD81, CD19, ICOS, IKZF1, CR2
immune response (GO:0006955) -2.860.001MS4A1, IL21, ICOS, CD19, CR2, NFKB1, NFKB2
leukocyte differentiation (GO:0002521) -4.130.006CD81, ICOS, CD19, CR2, NFKB1, IKZF1
regulation of immune response (GO:0050776) -2.980.001NFKB1, MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, NFKB2
leukocyte activation (GO:0045321) -3.760.0NFKB1, MS4A1, IL21, CD81, CD19, ICOS, IKZF1, CR2
positive regulation of lymphocyte activation (GO:0051251) -4.070.009ICOS, IL21, IKZF1, TNFRSF13C, NFKB1, NFKB2
positive regulation of immune response (GO:0050778) -3.40.001MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, NFKB1, NFKB2
immune system process (GO:0002376) -2.290.0NFKB2, MS4A1, IL21, ICOS, CD19, TNFRSF13C, CR2, NFKB1, IKZF1, TNFRSF13B
regulation of leukocyte activation (GO:0002694) -3.60.0NFKB2, IL21, ICOS, CD19, TNFRSF13C, CR2, NFKB1, IKZF1, TNFRSF13B
positive regulation of leukocyte activation (GO:0002696) -4.00.0ICOS, IL21, IKZF1, TNFRSF13C, CR2, NFKB1, NFKB2
lymphocyte differentiation (GO:0030098) -4.490.001CD81, ICOS, CD19, CR2, NFKB1, IKZF1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1112NFKB2, CD19, NFKB1, MS4A1, IL21, CD81, LRBA, TNFRSF13C, CR2, ICOS, IKZF1, TNFRSF13B
integral component of membrane (GO:0016021) 1.148CD19, MS4A1, CD81, ICOS, LRBA, TNFRSF13C, CR2, TNFRSF13B
membrane (GO:0016020) 0.688CD19, MS4A1, CD81, ICOS, LRBA, TNFRSF13C, CR2, TNFRSF13B
plasma membrane (GO:0005886) 1.398CD19, MS4A1, CD81, ICOS, LRBA, TNFRSF13C, CR2, TNFRSF13B
membrane part (GO:0044425) 0.958CD19, MS4A1, CD81, ICOS, LRBA, TNFRSF13C, CR2, TNFRSF13B
membrane-bounded organelle (GO:0043227) 0.478CD19, MS4A1, CD81, CR2, LRBA, NFKB1, IKZF1, NFKB2
organelle (GO:0043226) 0.48CD19, MS4A1, CD81, CR2, LRBA, NFKB1, IKZF1, NFKB2
intrinsic component of membrane (GO:0031224) 1.138CD19, MS4A1, CD81, ICOS, LRBA, TNFRSF13C, CR2, TNFRSF13B
plasma membrane part (GO:0044459) 1.956MS4A1, CD81, ICOS, CD19, TNFRSF13C, TNFRSF13B
protein complex (GO:0043234) 1.515IKZF1, NFKB1, NFKB2, CR2, CD19
external side of plasma membrane (GO:0009897) 4.465TNFRSF13C, MS4A1, TNFRSF13B, ICOS, CD19
macromolecular complex (GO:0032991) 1.355IKZF1, NFKB1, NFKB2, CR2, CD19
integral component of plasma membrane (GO:0005887) 2.575MS4A1, TNFRSF13B, CD19, ICOS, CD81
side of membrane (GO:0098552) 4.225TNFRSF13C, MS4A1, TNFRSF13B, ICOS, CD19
intrinsic component of plasma membrane (GO:0031226) 2.535TNFRSF13B, MS4A1, ICOS, CD81, CD19
extracellular region part (GO:0044421) 1.575CD81, MS4A1, IL21, CR2, CD19
intracellular membrane-bounded organelle (GO:0043231) 0.64LRBA, NFKB1, IKZF1, NFKB2
extracellular organelle (GO:0043230) 1.894MS4A1, CD81, CR2, CD19
extracellular exosome (GO:0070062) 1.894MS4A1, CD19, CR2, CD81
membrane-bounded vesicle (GO:0031988) 1.714MS4A1, CD81, CR2, CD19
intracellular organelle (GO:0043229) 0.514LRBA, NFKB1, IKZF1, NFKB2
intracellular part (GO:0044424) 0.284LRBA, NFKB1, IKZF1, NFKB2
extracellular vesicle (GO:1903561) 1.894MS4A1, CD19, CR2, CD81
vesicle (GO:0031982) 1.644MS4A1, CD81, CR2, CD19
cytoplasm (GO:0005737) 1.013NFKB1, IKZF1, NFKB2
nucleus (GO:0005634) 1.073NFKB1, IKZF1, NFKB2
cytoplasmic part (GO:0044444) 0.823NFKB1, LRBA, NFKB2
intracellular organelle part (GO:0044446) 0.812NFKB1, NFKB2
extracellular space (GO:0005615) 2.632MS4A1, IL21
cytosol (GO:0005829) 1.682NFKB1, NFKB2
intracellular (GO:0005622) 2.372CD19, IL21
nucleoplasm (GO:0005654) 1.892NFKB1, NFKB2
extracellular region (GO:0005576) 2.182ICOS, IL21
nuclear part (GO:0044428) 1.552NFKB1, NFKB2
I-kappaB/NF-kappaB complex (GO:0033256) 7.722NFKB1, NFKB2
organelle part (GO:0044422) 0.792NFKB1, NFKB2

NET-GE enrichment

Term New enriched termICP valueGenes
external side of plasma membrane (GO:0009897) -4.460.0MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, TNFRSF13B
extracellular space (GO:0005615) -2.630.045MS4A1, IL21, CD81, CD19, CR2, NFKB1, IKZF1, NFKB2
integral component of plasma membrane (GO:0005887) -2.570.018MS4A1, TNFRSF13B, CD19, ICOS, CD81
side of membrane (GO:0098552) -4.220.0MS4A1, IL21, CD81, CD19, TNFRSF13C, CR2, ICOS, TNFRSF13B
I-kappaB/NF-kappaB complex (GO:0033256) -7.720.0NFKB1, NFKB2
plasma membrane part (GO:0044459) -1.950.009MS4A1, CD81, ICOS, CD19, TNFRSF13C, CR2, TNFRSF13B