Disease table of THYROID CARCINOMA, FAMILIAL MEDULLARY OMIM ID: 155240

Gene-disease associations table

GeneAssociated with THYROID CARCINOMA, FAMILIAL MEDULLARY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
NTRK1ClinVar, OMIMHGNC link1q23.12PS162400, 155240
RETClinVar, OMIM, HUMSAVARHGNC link10q11.216171300, 155240, PS142623, 209880, 191830, PS131100

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NTRK1YES2MYCN, ING40
RETYES5TFAP2C, SOX9, ESR1, SOX10, FOXA10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NTRK1RETYes20HSP90AA1, STAT3, PLCG1, FRS2, NOTCH3, HNRNPD, MAPK1, RET, PTPRF, ZCCHC8, BAG6, CBL, SYNCRIP, NTRK1, SORT1, PTK2, EGFR, SRC, SHC1, GRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
NTRK1RETmaybe, indirectThey are both tyrosine kinase receptors. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Central carbon metabolism in cancerhsa052306.72NTRK1, RET
Thyroid cancerhsa052167.482NTRK1, RET
Pathways in cancerhsa052003.982NTRK1, RET
Endocytosishsa041444.922NTRK1, RET

NET-GE enrichment

Term New enriched termICP valueGenes
Central carbon metabolism in cancer (hsa05230) -6.70.002NTRK1, RET
Thyroid cancer (hsa05216) -7.480.001NTRK1, RET
Endocytosis (hsa04144) -4.920.023NTRK1, RET
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
signaling receptor activity (GO:0038023) 2.492NTRK1, RET
purine ribonucleoside triphosphate binding (GO:0035639) 2.222NTRK1, RET
molecular transducer activity (GO:0060089) 2.322NTRK1, RET
receptor activity (GO:0004872) 2.322NTRK1, RET
signal transducer activity (GO:0004871) 2.282NTRK1, RET
purine nucleoside binding (GO:0001883) 2.222NTRK1, RET
heterocyclic compound binding (GO:1901363) 1.062NTRK1, RET
nucleoside phosphate binding (GO:1901265) 1.962NTRK1, RET
nucleoside binding (GO:0001882) 2.212NTRK1, RET
transferase activity (GO:0016740) 1.952NTRK1, RET
nucleotide binding (GO:0000166) 1.962NTRK1, RET
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.552NTRK1, RET
protein tyrosine kinase activity (GO:0004713) 4.542NTRK1, RET
protein kinase activity (GO:0004672) 3.272NTRK1, RET
purine nucleotide binding (GO:0017076) 2.192NTRK1, RET
ATP binding (GO:0005524) 2.432NTRK1, RET
kinase activity (GO:0016301) 2.932NTRK1, RET
small molecule binding (GO:0036094) 1.892NTRK1, RET
catalytic activity (GO:0003824) 1.052NTRK1, RET
adenyl nucleotide binding (GO:0030554) 2.42NTRK1, RET
carbohydrate derivative binding (GO:0097367) 2.032NTRK1, RET
organic cyclic compound binding (GO:0097159) 1.052NTRK1, RET
ribonucleoside binding (GO:0032549) 2.222NTRK1, RET
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082NTRK1, RET
transmembrane signaling receptor activity (GO:0004888) 2.572NTRK1, RET
adenyl ribonucleotide binding (GO:0032559) 2.412NTRK1, RET
transmembrane receptor activity (GO:0099600) 2.532NTRK1, RET
protein binding (GO:0005515) 0.462NTRK1, RET
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772NTRK1, RET
purine ribonucleotide binding (GO:0032555) 2.22NTRK1, RET
transmembrane receptor protein kinase activity (GO:0019199) 5.322NTRK1, RET
purine ribonucleoside binding (GO:0032550) 2.222NTRK1, RET
ribonucleotide binding (GO:0032553) 2.192NTRK1, RET
binding (GO:0005488) 0.182NTRK1, RET

NET-GE enrichment

Term New enriched termICP valueGenes
transmembrane receptor protein tyrosine kinase activity (GO:0004714) -5.550.001NTRK1, RET
protein tyrosine kinase activity (GO:0004713) -4.540.004NTRK1, RET
transmembrane receptor protein kinase activity (GO:0019199) -5.320.01NTRK1, RET
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.352NTRK1, RET
regulation of primary metabolic process (GO:0080090) 1.082NTRK1, RET
regulation of metabolic process (GO:0019222) 1.022NTRK1, RET
positive regulation of response to stimulus (GO:0048584) 2.182NTRK1, RET
regulation of response to stimulus (GO:0048583) 1.542NTRK1, RET
signal transduction (GO:0007165) 1.282NTRK1, RET
cell surface receptor signaling pathway (GO:0007166) 2.092NTRK1, RET
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242NTRK1, RET
neuron differentiation (GO:0030182) 4.172NTRK1, RET
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542NTRK1, RET
regulation of cell projection organization (GO:0031344) 3.382NTRK1, RET
cellular component organization or biogenesis (GO:0071840) 1.222NTRK1, RET
positive regulation of cell projection organization (GO:0031346) 3.992NTRK1, RET
cellular response to stimulus (GO:0051716) 1.972NTRK1, RET
positive regulation of macromolecule metabolic process (GO:0010604) 1.812NTRK1, RET
regulation of signal transduction (GO:0009966) 1.842NTRK1, RET
cellular developmental process (GO:0048869) 1.822NTRK1, RET
peptidyl-tyrosine modification (GO:0018212) 4.472NTRK1, RET
cellular response to organic substance (GO:0071310) 2.782NTRK1, RET
peptidyl-amino acid modification (GO:0018193) 2.982NTRK1, RET
regulation of neuron differentiation (GO:0045664) 3.392NTRK1, RET
positive regulation of neuron differentiation (GO:0045666) 3.982NTRK1, RET
positive regulation of molecular function (GO:0044093) 2.232NTRK1, RET
positive regulation of biological process (GO:0048518) 1.22NTRK1, RET
regulation of macromolecule metabolic process (GO:0060255) 1.082NTRK1, RET
positive regulation of neuron projection development (GO:0010976) 4.262NTRK1, RET
regulation of neuron projection development (GO:0010975) 3.692NTRK1, RET
regulation of RNA biosynthetic process (GO:2001141) 1.552NTRK1, RET
response to organic substance (GO:0010033) 2.22NTRK1, RET
regulation of phosphorylation (GO:0042325) 2.52NTRK1, RET
positive regulation of phosphorylation (GO:0042327) 2.92NTRK1, RET
single-multicellular organism process (GO:0044707) 1.782NTRK1, RET
protein metabolic process (GO:0019538) 1.452NTRK1, RET
regulation of gene expression (GO:0010468) 1.372NTRK1, RET
immune system process (GO:0002376) 2.292NTRK1, RET
positive regulation of metabolic process (GO:0009893) 1.742NTRK1, RET
regulation of anatomical structure morphogenesis (GO:0022603) 2.792NTRK1, RET
movement of cell or subcellular component (GO:0006928) 2.612NTRK1, RET
intracellular signal transduction (GO:0035556) 2.392NTRK1, RET
regulation of apoptotic process (GO:0042981) 2.52NTRK1, RET
regulation of biological process (GO:0050789) 0.452NTRK1, RET
cellular protein metabolic process (GO:0044267) 1.632NTRK1, RET
anatomical structure morphogenesis (GO:0009653) 2.532NTRK1, RET
positive regulation of GTPase activity (GO:0043547) 3.282NTRK1, RET
positive regulation of hydrolase activity (GO:0051345) 2.912NTRK1, RET
innervation (GO:0060384) 6.782NTRK1, RET
cellular component organization (GO:0016043) 1.242NTRK1, RET
biological regulation (GO:0065007) 0.392NTRK1, RET
positive regulation of catalytic activity (GO:0043085) 2.42NTRK1, RET
regulation of molecular function (GO:0065009) 1.782NTRK1, RET
positive regulation of cellular component organization (GO:0051130) 2.682NTRK1, RET
regulation of developmental process (GO:0050793) 2.12NTRK1, RET
regulation of catalytic activity (GO:0050790) 1.972NTRK1, RET
regulation of biosynthetic process (GO:0009889) 1.372NTRK1, RET
regulation of cellular process (GO:0050794) 0.52NTRK1, RET
macromolecule modification (GO:0043412) 1.732NTRK1, RET
protein modification process (GO:0036211) 1.792NTRK1, RET
regulation of multicellular organismal process (GO:0051239) 1.872NTRK1, RET
regulation of intracellular signal transduction (GO:1902531) 2.312NTRK1, RET
regulation of hydrolase activity (GO:0051336) 2.532NTRK1, RET
regulation of phosphorus metabolic process (GO:0051174) 2.352NTRK1, RET
response to stimulus (GO:0050896) 1.222NTRK1, RET
positive regulation of protein modification process (GO:0031401) 2.72NTRK1, RET
response to stress (GO:0006950) 1.82NTRK1, RET
positive regulation of nervous system development (GO:0051962) 3.642NTRK1, RET
regulation of nervous system development (GO:0051960) 3.12NTRK1, RET
positive regulation of signal transduction (GO:0009967) 2.52NTRK1, RET
positive regulation of multicellular organismal process (GO:0051240) 2.492NTRK1, RET
metabolic process (GO:0008152) 0.582NTRK1, RET
phosphorylation (GO:0016310) 2.632NTRK1, RET
cell differentiation (GO:0030154) 2.142NTRK1, RET
regulation of cellular component organization (GO:0051128) 2.012NTRK1, RET
positive regulation of signaling (GO:0023056) 2.412NTRK1, RET
cellular response to chemical stimulus (GO:0070887) 2.572NTRK1, RET
regulation of signaling (GO:0023051) 1.722NTRK1, RET
positive regulation of cell communication (GO:0010647) 2.412NTRK1, RET
regulation of cell communication (GO:0010646) 1.732NTRK1, RET
regulation of GTPase activity (GO:0043087) 3.212NTRK1, RET
single-organism process (GO:0044699) 0.482NTRK1, RET
regulation of neurogenesis (GO:0050767) 3.212NTRK1, RET
positive regulation of phosphorus metabolic process (GO:0010562) 2.782NTRK1, RET
regulation of protein metabolic process (GO:0051246) 1.932NTRK1, RET
positive regulation of protein metabolic process (GO:0051247) 2.432NTRK1, RET
regulation of cell development (GO:0060284) 3.012NTRK1, RET
positive regulation of neurogenesis (GO:0050769) 3.772NTRK1, RET
positive regulation of cellular protein metabolic process (GO:0032270) 2.492NTRK1, RET
regulation of protein modification process (GO:0031399) 2.322NTRK1, RET
developmental process (GO:0032502) 1.362NTRK1, RET
multicellular organismal process (GO:0032501) 1.452NTRK1, RET
positive regulation of cell development (GO:0010720) 3.572NTRK1, RET
cellular process (GO:0009987) 0.262NTRK1, RET
regulation of nucleic acid-templated transcription (GO:1903506) 1.552NTRK1, RET
positive regulation of cell differentiation (GO:0045597) 3.012NTRK1, RET
regulation of cell differentiation (GO:0045595) 2.422NTRK1, RET
response to acid chemical (GO:0001101) 4.052NTRK1, RET
regulation of cellular protein metabolic process (GO:0032268) 1.992NTRK1, RET
positive regulation of developmental process (GO:0051094) 2.772NTRK1, RET
regulation of RNA metabolic process (GO:0051252) 1.522NTRK1, RET
response to drug (GO:0042493) 3.712NTRK1, RET
macromolecule metabolic process (GO:0043170) 0.832NTRK1, RET
system development (GO:0048731) 2.922NTRK1, RET
regulation of cellular biosynthetic process (GO:0031326) 1.382NTRK1, RET
positive regulation of cellular metabolic process (GO:0031325) 1.812NTRK1, RET
regulation of cellular metabolic process (GO:0031323) 1.072NTRK1, RET
peptidyl-tyrosine phosphorylation (GO:0018108) 4.482NTRK1, RET
positive regulation of cell death (GO:0010942) 3.322NTRK1, RET
regulation of cell death (GO:0010941) 2.432NTRK1, RET
regulation of transcription, DNA-templated (GO:0006355) 1.562NTRK1, RET
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462NTRK1, RET
organic substance metabolic process (GO:0071704) 0.632NTRK1, RET
regulation of programmed cell death (GO:0043067) 2.492NTRK1, RET
regulation of macromolecule biosynthetic process (GO:0010556) 1.432NTRK1, RET
positive regulation of programmed cell death (GO:0043068) 3.382NTRK1, RET
protein phosphorylation (GO:0006468) 2.892NTRK1, RET
positive regulation of phosphate metabolic process (GO:0045937) 2.782NTRK1, RET
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432NTRK1, RET
cellular protein modification process (GO:0006464) 1.792NTRK1, RET
single-organism developmental process (GO:0044767) 1.492NTRK1, RET
single-organism cellular process (GO:0044763) 0.652NTRK1, RET
regulation of nitrogen compound metabolic process (GO:0051171) 1.362NTRK1, RET
response to chemical (GO:0042221) 1.982NTRK1, RET
response to oxygen-containing compound (GO:1901700) 2.572NTRK1, RET
primary metabolic process (GO:0044238) 0.692NTRK1, RET
cellular macromolecule metabolic process (GO:0044260) 0.932NTRK1, RET
nervous system development (GO:0007399) 3.532NTRK1, RET
anatomical structure development (GO:0048856) 1.582NTRK1, RET
cellular metabolic process (GO:0044237) 0.692NTRK1, RET
phosphate-containing compound metabolic process (GO:0006796) 2.162NTRK1, RET
regulation of multicellular organismal development (GO:2000026) 2.312NTRK1, RET
phosphorus metabolic process (GO:0006793) 2.152NTRK1, RET
regulation of protein phosphorylation (GO:0001932) 2.572NTRK1, RET
positive regulation of protein phosphorylation (GO:0001934) 2.952NTRK1, RET
positive regulation of cellular process (GO:0048522) 1.32NTRK1, RET

NET-GE enrichment

Term New enriched termICP valueGenes
membrane protein proteolysis (GO:0033619) NEW6.170.005NTRK1, RET
peptidyl-tyrosine modification (GO:0018212) -4.470.03NTRK1, RET
peptidyl-tyrosine phosphorylation (GO:0018108) -4.480.03NTRK1, RET
sympathetic nervous system development (GO:0048485) NEW6.960.002NTRK1, RET
positive regulation of neuron projection development (GO:0010976) -4.260.007NTRK1, RET
nerve development (GO:0021675) NEW6.290.023NTRK1, RET
positive regulation of cell projection organization (GO:0031346) -3.990.042NTRK1, RET
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
dendrite (GO:0030425) 3.922NTRK1, RET
axon (GO:0030424) 4.152NTRK1, RET
intracellular organelle (GO:0043229) 0.512NTRK1, RET
membrane-bounded organelle (GO:0043227) 0.472NTRK1, RET
organelle (GO:0043226) 0.42NTRK1, RET
intrinsic component of membrane (GO:0031224) 1.132NTRK1, RET
endosome membrane (GO:0010008) 3.832NTRK1, RET
cytoplasm (GO:0005737) 1.012NTRK1, RET
organelle membrane (GO:0031090) 1.972NTRK1, RET
vacuole (GO:0005773) 2.922NTRK1, RET
intrinsic component of plasma membrane (GO:0031226) 2.532NTRK1, RET
integral component of membrane (GO:0016021) 1.142NTRK1, RET
membrane (GO:0016020) 0.682NTRK1, RET
vacuolar membrane (GO:0005774) 3.452NTRK1, RET
neuron part (GO:0097458) 2.642NTRK1, RET
vacuolar part (GO:0044437) 3.262NTRK1, RET
neuron projection (GO:0043005) 3.122NTRK1, RET
neuronal cell body (GO:0043025) 3.92NTRK1, RET
bounding membrane of organelle (GO:0098588) 2.392NTRK1, RET
cell body (GO:0044297) 3.742NTRK1, RET
integral component of plasma membrane (GO:0005887) 2.572NTRK1, RET
plasma membrane (GO:0005886) 1.392NTRK1, RET
cell projection (GO:0042995) 2.472NTRK1, RET
protein complex (GO:0043234) 1.512NTRK1, RET
receptor complex (GO:0043235) 4.012NTRK1, RET
macromolecular complex (GO:0032991) 1.352NTRK1, RET
intracellular membrane-bounded organelle (GO:0043231) 0.62NTRK1, RET
plasma membrane part (GO:0044459) 1.952NTRK1, RET
cell part (GO:0044464) 0.112NTRK1, RET
early endosome (GO:0005769) 4.342NTRK1, RET
intracellular organelle part (GO:0044446) 0.812NTRK1, RET
cytoplasmic part (GO:0044444) 0.822NTRK1, RET
endosomal part (GO:0044440) 3.732NTRK1, RET
intracellular part (GO:0044424) 0.282NTRK1, RET
membrane part (GO:0044425) 0.952NTRK1, RET
endosome (GO:0005768) 3.252NTRK1, RET
whole membrane (GO:0098805) 2.852NTRK1, RET
organelle part (GO:0044422) 0.792NTRK1, RET

NET-GE enrichment

Term New enriched termICP valueGenes
receptor complex (GO:0043235) -4.010.008NTRK1, RET
endosomal part (GO:0044440) -3.730.02NTRK1, RET
endosome membrane (GO:0010008) -3.830.018NTRK1, RET