Disease table of COUMARIN RESISTANCE OMIM ID: 122700

Gene-disease associations table

GeneAssociated with COUMARIN RESISTANCE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CYP2C9OMIMHGNC link10q23.331122700
F9OMIMHGNC linkXq27.13PS188050, 306900, 122700
VKORC1OMIM, HUMSAVARHGNC link16p11.22122700, PS277450
CYP2A6OMIMHGNC link19q13.23188890, 122700, 211980

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CYP2C9YES6PPARGC1A, NCOA6, NR1I3, NR1I2, PPARA, HNF4A0
F9YES1CEBPA0
CYP2A6YES1NFYA0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CYP2C9CYP2A6No1POR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CYP2C9CYP2A6No-1CYB5A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolism of xenobiotics by cytochrome P450hsa009806.482CYP2C9, CYP2A6
Metabolic pathwayshsa011002.492CYP2C9, CYP2A6
Drug metabolism - cytochrome P450hsa009826.62CYP2C9, CYP2A6
Retinol metabolismhsa008306.792CYP2C9, CYP2A6
Chemical carcinogenesishsa052046.362CYP2C9, CYP2A6

NET-GE enrichment

Term New enriched termICP valueGenes
Metabolism of xenobiotics by cytochrome P450 (hsa00980) -6.480.018CYP2C9, CYP2A6
Drug metabolism - cytochrome P450 (hsa00982) -6.60.015CYP2C9, CYP2A6
Chemical carcinogenesis (hsa05204) -6.360.029CYP2C9, CYP2A6
Metabolism of cofactors and vitaminsNEW5.160.01CYP2A6, CYP2C9, VKORC1
Retinol metabolism (hsa00830) -6.790.023CYP2C9, CYP2A6
Xenobiotics biodegradation and metabolismNEW5.920.038CYP2C9, CYP2A6
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cytochrome P450 - arranged by substrate typeR-HSA-2118977.082CYP2C9, CYP2A6
Biological oxidationsR-HSA-2118595.552CYP2C9, CYP2A6
CYP2E1 reactionsR-HSA-2119999.522CYP2C9, CYP2A6
Gamma carboxylation, hypusine formation and arylsulfatase activationR-HSA-1638417.812F9, VKORC1
XenobioticsR-HSA-2119818.662CYP2C9, CYP2A6
Metabolism of proteinsR-HSA-3924993.412F9, VKORC1
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsR-HSA-1598549.522F9, VKORC1
Phase 1 - Functionalization of compoundsR-HSA-2119456.72CYP2C9, CYP2A6
MetabolismR-HSA-14307282.342CYP2C9, CYP2A6
Post-translational protein modificationR-HSA-5975924.542F9, VKORC1

NET-GE enrichment

Term New enriched termICP valueGenes
Cytochrome P450 - arranged by substrate type (R-HSA-211897) -7.080.007CYP2C9, CYP2A6
CYP2E1 reactions (R-HSA-211999) -9.520.0CYP2C9, CYP2A6
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841) -7.810.003F9, VKORC1
Xenobiotics (R-HSA-211981) -8.660.002CYP2C9, CYP2A6
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (R-HSA-159854) -9.520.0F9, VKORC1
Phase 1 - Functionalization of compounds (R-HSA-211945) -6.70.012CYP2C9, CYP2A6
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.054CYP2A6, CYP2C9, F9, VKORC1
binding (GO:0005488) 0.184CYP2A6, CYP2C9, F9, VKORC1
metal ion binding (GO:0046872) 1.413CYP2A6, CYP2C9, F9
cation binding (GO:0043169) 1.43CYP2A6, CYP2C9, F9
ion binding (GO:0043167) 1.363CYP2A6, CYP2C9, F9
oxidoreductase activity (GO:0016491) 3.123CYP2A6, CYP2C9, VKORC1
monooxygenase activity (GO:0004497) 5.12CYP2C9, CYP2A6
transition metal ion binding (GO:0046914) 2.482CYP2C9, CYP2A6
heme binding (GO:0020037) 4.862CYP2C9, CYP2A6
tetrapyrrole binding (GO:0046906) 4.82CYP2C9, CYP2A6
organic cyclic compound binding (GO:0097159) 1.052CYP2C9, CYP2A6
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705) 4.652CYP2C9, CYP2A6
iron ion binding (GO:0005506) 4.652CYP2C9, CYP2A6
steroid hydroxylase activity (GO:0008395) 6.32CYP2C9, CYP2A6
arachidonic acid epoxygenase activity (GO:0008392) 7.032CYP2C9, CYP2A6
heterocyclic compound binding (GO:1901363) 1.062CYP2C9, CYP2A6
arachidonic acid monooxygenase activity (GO:0008391) 7.032CYP2C9, CYP2A6

NET-GE enrichment

Term New enriched termICP valueGenes
monooxygenase activity (GO:0004497) -5.10.034CYP2C9, CYP2A6
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705) -4.650.024CYP2C9, CYP2A6
heme binding (GO:0020037) -4.860.017CYP2C9, CYP2A6
tetrapyrrole binding (GO:0046906) -4.80.019CYP2C9, CYP2A6
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712) NEW6.370.002CYP2C9, CYP2A6
iron ion binding (GO:0005506) -4.650.026CYP2C9, CYP2A6
oxidoreductase activity (GO:0016491) -3.120.015CYP2A6, CYP2C9, VKORC1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
primary metabolic process (GO:0044238) 0.694CYP2A6, CYP2C9, F9, VKORC1
cellular process (GO:0009987) 0.264CYP2A6, CYP2C9, F9, VKORC1
cellular metabolic process (GO:0044237) 0.694CYP2A6, CYP2C9, F9, VKORC1
organic substance metabolic process (GO:0071704) 0.634CYP2A6, CYP2C9, F9, VKORC1
metabolic process (GO:0008152) 0.584CYP2A6, CYP2C9, F9, VKORC1
single-organism process (GO:0044699) 0.484CYP2A6, CYP2C9, F9, VKORC1
single-organism metabolic process (GO:0044710) 1.633CYP2A6, CYP2C9, VKORC1
drug metabolic process (GO:0017144) 6.043CYP2A6, CYP2C9, VKORC1
single-organism cellular process (GO:0044763) 0.653CYP2A6, CYP2C9, VKORC1
small molecule metabolic process (GO:0044281) 2.383CYP2A6, CYP2C9, VKORC1
oxidation-reduction process (GO:0055114) 2.913CYP2A6, CYP2C9, VKORC1
fatty acid metabolic process (GO:0006631) 4.032CYP2C9, CYP2A6
hemostasis (GO:0007599) 4.52F9, VKORC1
blood coagulation (GO:0007596) 4.522F9, VKORC1
carboxylic acid metabolic process (GO:0019752) 3.122CYP2C9, CYP2A6
cellular catabolic process (GO:0044248) 2.622CYP2C9, CYP2A6
long-chain fatty acid metabolic process (GO:0001676) 5.272CYP2C9, CYP2A6
cellular nitrogen compound metabolic process (GO:0034641) 1.222CYP2C9, F9
nitrogen compound metabolic process (GO:0006807) 1.132CYP2C9, F9
organic cyclic compound metabolic process (GO:1901360) 1.262CYP2C9, CYP2A6
cellular protein metabolic process (GO:0044267) 1.632F9, VKORC1
cellular macromolecule metabolic process (GO:0044260) 0.932F9, VKORC1
protein carboxylation (GO:0018214) 7.332F9, VKORC1
peptidyl-amino acid modification (GO:0018193) 2.982F9, VKORC1
biological regulation (GO:0065007) 0.392F9, VKORC1
organic acid metabolic process (GO:0006082) 3.012CYP2C9, CYP2A6
regulation of biological quality (GO:0065008) 1.682F9, VKORC1
epoxygenase P450 pathway (GO:0019373) 6.842CYP2C9, CYP2A6
multicellular organismal process (GO:0032501) 1.452F9, VKORC1
lipid metabolic process (GO:0006629) 2.682CYP2C9, CYP2A6
regulation of body fluid levels (GO:0050878) 3.762F9, VKORC1
cellular protein modification process (GO:0006464) 1.792F9, VKORC1
monocarboxylic acid metabolic process (GO:0032787) 3.572CYP2C9, CYP2A6
macromolecule modification (GO:0043412) 1.732F9, VKORC1
protein modification process (GO:0036211) 1.792F9, VKORC1
oxoacid metabolic process (GO:0043436) 3.122CYP2C9, CYP2A6
cellular lipid metabolic process (GO:0044255) 2.922CYP2C9, CYP2A6
catabolic process (GO:0009056) 2.382CYP2C9, CYP2A6
steroid metabolic process (GO:0008202) 4.322CYP2C9, CYP2A6
drug catabolic process (GO:0042737) 7.092CYP2C9, CYP2A6
organonitrogen compound metabolic process (GO:1901564) 2.322CYP2C9, F9
cellular amide metabolic process (GO:0043603) 3.232CYP2C9, F9
single-multicellular organism process (GO:0044707) 1.782F9, VKORC1
protein metabolic process (GO:0019538) 1.452F9, VKORC1
exogenous drug catabolic process (GO:0042738) 7.332CYP2C9, CYP2A6
peptidyl-glutamic acid carboxylation (GO:0017187) 7.332F9, VKORC1
peptidyl-glutamic acid modification (GO:0018200) 6.332F9, VKORC1
macromolecule metabolic process (GO:0043170) 0.832F9, VKORC1
icosanoid metabolic process (GO:0006690) 5.22CYP2C9, CYP2A6
coagulation (GO:0050817) 4.512F9, VKORC1
arachidonic acid metabolic process (GO:0019369) 5.82CYP2C9, CYP2A6
unsaturated fatty acid metabolic process (GO:0033559) 5.12CYP2C9, CYP2A6

NET-GE enrichment

Term New enriched termICP valueGenes
drug catabolic process (GO:0042737) -7.090.001CYP2C9, CYP2A6
exogenous drug catabolic process (GO:0042738) -7.330.001CYP2C9, CYP2A6
peptidyl-glutamic acid carboxylation (GO:0017187) -7.330.0F9, VKORC1
peptidyl-glutamic acid modification (GO:0018200) -6.330.001F9, VKORC1
xenobiotic metabolic process (GO:0006805) NEW5.190.038CYP2C9, CYP2A6
drug metabolic process (GO:0017144) -6.040.0CYP2A6, CYP2C9, VKORC1
protein carboxylation (GO:0018214) -7.330.0F9, VKORC1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane (GO:0016020) 0.684CYP2A6, CYP2C9, F9, VKORC1
cell part (GO:0044464) 0.114CYP2A6, CYP2C9, F9, VKORC1
intracellular organelle part (GO:0044446) 0.814CYP2A6, CYP2C9, F9, VKORC1
endoplasmic reticulum part (GO:0044432) 2.734CYP2A6, CYP2C9, F9, VKORC1
cytoplasmic part (GO:0044444) 0.824CYP2A6, CYP2C9, F9, VKORC1
intracellular part (GO:0044424) 0.284CYP2A6, CYP2C9, F9, VKORC1
membrane-bounded organelle (GO:0043227) 0.474CYP2A6, CYP2C9, F9, VKORC1
organelle (GO:0043226) 0.44CYP2A6, CYP2C9, F9, VKORC1
organelle part (GO:0044422) 0.794CYP2A6, CYP2C9, F9, VKORC1
intracellular membrane-bounded organelle (GO:0043231) 0.63CYP2A6, CYP2C9, VKORC1
membrane part (GO:0044425) 0.953CYP2A6, CYP2C9, VKORC1
intracellular organelle (GO:0043229) 0.513CYP2A6, CYP2C9, VKORC1
endoplasmic reticulum (GO:0005783) 2.563CYP2A6, CYP2C9, VKORC1
endoplasmic reticulum membrane (GO:0005789) 2.953CYP2A6, CYP2C9, VKORC1
integral component of membrane (GO:0016021) 1.142VKORC1, CYP2A6
organelle membrane (GO:0031090) 1.972CYP2C9, CYP2A6
intrinsic component of membrane (GO:0031224) 1.132VKORC1, CYP2A6

NET-GE enrichment

Term New enriched termICP valueGenes
endoplasmic reticulum part (GO:0044432) -2.730.0CYP2A6, CYP2C9, F9, VKORC1
membrane region (GO:0098589) NEW3.950.049CYP2A6, CYP2C9, VKORC1
endoplasmic reticulum membrane (GO:0005789) -2.950.009CYP2A6, CYP2C9, VKORC1