Disease table of LUNG CANCER OMIM ID: 211980

Gene-disease associations table

Gene	Associated with LUNG CANCER in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
ERBB2	OMIM	HGNC link	17q12	3	PS137800, 613659, 211980
IRF1	OMIM	HGNC link	5q31.1	2	613659, 211980
SLC22A18	OMIM, HUMSAVAR	HGNC link	11p15.4	3	114480, 268210, 211980
ERCC6	OMIM	HGNC link	10q11.23	6	211980, PS603075, 133540, PS600630, PS214150, 278800
RASSF1	OMIM	HGNC link	3p21.31	1	211980
PIK3CA	OMIM	HGNC link	3q26.32	11	114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
EGFR	OMIM	HGNC link	7p11.2	3	275355, 211980, PS614328
MAP3K8	OMIM	HGNC link	10p11.23	1	211980
CASP8	OMIM	HGNC link	2q33.1	4	114550, 607271, 211980, 114480
PARK2	OMIM	HGNC link	6q26	4	PS168600, 167000, 607572, 211980
DLEC1	OMIM	HGNC link	3p22.2	2	133239, 211980
FASLG	OMIM	HGNC link	1q24.3	2	601859, 211980
BRAF	OMIM, HUMSAVAR	HGNC link	7q34	8	605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500
PPP2R1B	OMIM	HGNC link	11q23.1	1	211980
MXRA5	HUMSAVAR	HGNC link	Xp22.33	1	211980
KRAS	OMIM	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350
CYP2A6	OMIM	HGNC link	19q13.2	3	188890, 122700, 211980

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
3p2	2	RASSF1, DLEC1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3p	2	RASSF1, DLEC1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	PPP2R1B, SLC22A18
10	2	MAP3K8, ERCC6
3	3	RASSF1, PIK3CA, DLEC1
7	2	EGFR, BRAF

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
IRF1	YES	51	EIF2AK2, IFNA13, PSMB10, IL12A, NCF2, CEACAM1, MMP9, MYB, PSMB9, IL12B, TAP2, CCNE1, CCL5, SOCS2, VCAM1, TNFSF10, SOCS1, MAPK14, IFNA1, HLA-G, CASP7, CDKN1A, IFNB1, CCNB1, FOXP3, OGN, PIGR, IL10, TAP1, TP53, TRIM22, HLA-A, DDX58, CD40, ERAP2, IL27, CDK1, E2F1, TAPBP, CYBB, CDK2, BCL2, CDK4, CXCL10, SLPI, IRF2, DST, IFIT3, CIITA, IFNG, FASLG	1	FASLG
VDR	NO	36	DKK4, CST5, PRL, LRP5, IGFBP3, BGLAP, EGFR, TPT1, IL12B, SKP2, PHB, CYP7A1, RUNX2, TNFRSF21, CYP1A1, ERBB2, CD14, CYP24A1, CYP3A4, CDKN1B, FOXP3, PODXL, IL10, HOXA10, CDH1, CALB1, SPP1, AMH, TRPV6, DDIT4, CXCL8, IL2, PTH, IL6, CAMP, TNFSF11	2	ERBB2, EGFR
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	ERBB2, EGFR
MYC	NO	102	CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1	2	KRAS, FASLG
WWP1	NO	5	ERBB4, BRCA1, ERBB2, EGFR, TGFBR1	2	ERBB2, EGFR
FOXO3	NO	17	SIRT6, BIRC5, CCND2, BCL6, FOXM1, TNFSF10, VEGFB, BBC3, AR, PIK3CA, TXNIP, MYOCD, FASLG, CDKN2B, VEGFA, BCL2L11, GALT	2	FASLG, PIK3CA
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	2	IRF1, EGFR
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	2	IRF1, EGFR
TFAP2A	NO	69	SLC19A1, POLD2, L1CAM, MCAM, GALNT3, CRYAB, KISS1, CGB, EGFR, HTT, GAST, COL1A1, NME3, PTGS2, SPRY2, ACHE, MUC4, DBH, FOXA1, GUSB, DCBLD2, IGFBP5, CFTR, HSD17B1, ERBB2, ETS1, CD82, CYP11A1, PVR, ADM, KRT5, KIT, CCNB1, HGF, F2R, ECM1, APP, MPG, CRABP2, CDH1, PTEN, KLF12, VEGFA, GPX4, SULT1E1, CGA, LNPEP, TIMP2, MMP9, HOXA4, TAF7, NR3C1, BCL2, PLAUR, TH, ADRA2B, MMP2, CDKN1A, FAS, ADRA1A, IMPDH2, SNAP91, PRKCA, HMOX1, BACE1, CRX, BRS3, HIP1, CSH1	2	ERBB2, EGFR
CIITA	NO	30	IRF2, HDAC2, COL1A2, HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-DRA, IL4, HLA-DMA, HLA-C, SIRT1, HLA-DQB1, HLA-B, SLC26A3, HLA-A, PLXNA1, COL1A1, HLA-DMB, HLA-DRB5, S100A4, MMP9, IRF1, PSMC5, HLA-DOB, HLA-DOA, HLA-DPB1, HLA-G, RAB4B, CREBBP, FASLG	2	IRF1, FASLG
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	EGFR, FASLG
PGR	NO	27	BCL2L1, PRL, ATP1B1, PTGER2, EGFR, HLTF, KLK4, PTGS2, CYP19A1, BCL2, CCND1, ERBB2, RLN2, E2F1, ABCG2, IRS2, FOXP3, PLD1, IL10, RLN1, RELA, VEGFA, DUSP1, IGFBP1, ESR1, MYC, YWHAQ	2	ERBB2, EGFR
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	2	EGFR, FASLG
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	IRF1, EGFR, FASLG
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	IRF1, EGFR, FASLG
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	4	FASLG, ERBB2, EGFR, RASSF1
SP3	NO	109	DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC6	2	ERBB2, RASSF1
CREB1	NO	90	NDC80, NRF1, IFNG, NR2F1, CYP19A1, CASP8, LDHA, SMAD6, SLC19A1, GSK3A, IL10, PSEN1, PPP2R2B, JUN, HPGD, IL2, GABPA, MC2R, CRTC1, AR, FLT1, SLC39A1, BDKRB2, NPY, PTGS2, MSMB, CFTR, HMOX1, MITF, AQP3, MUC5AC, STMN1, TRH, PCSK1, MMP2, CYP17A1, NOLC1, PRL, NMNAT2, TLR9, NTS, PLAT, FOS, BCL2L11, MUC4, GSK3B, CYP11B1, PPM1D, CCK, ETV3, PTGES, UXT, HLA-DOB, CGA, XPC, ACACA, SLC22A8, TH, VIP, BDKRB1, CYP11B2, POLD2, LAPTM4B, SOX9, PLAU, SNAI1, PPP2CA, SNAI2, SPRY2, HLA-DQB1, CCL5, CXCR4, ADRA1A, NR5A2, ERBB2, GRPR, BDNF, NR4A3, IL5RA, SLC20A1, RRM2B, LYL1, BCL2, CD4, NR2F6, NF1, IL6, CYP11A1, ODC1, FOXA1	2	ERBB2, CASP8
PPARG	NO	69	BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG	2	EGFR, FASLG
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	2	ERBB2, EGFR
TP53	NO	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	2	EGFR, RASSF1
YBX1	NO	29	AR, RAD9A, MET, ANAPC4, CKS2, AGT, EGFR, SKP2, TYMS, FAS, SLC6A4, CXCR4, CCNC, ERBB2, ERBB3, RBBP8, E2F1, CDC20, CDKN3, TOP2A, CDH1, SUMO1, MMP2, KPNA2, ABCB1, MMP13, CCNB1, MNAT1, MYCN	2	ERBB2, EGFR
CREBBP	NO	27	ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD51	2	IRF1, EGFR

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
ERBB2	YES	30	AR, WWP1, ECD, TFAP2A, PAX2, MYB, PURA, PGR, JUND, SP1, ETV4, GATA4, NCOA3, CREB1, VDR, TFAP2B, ATF7, ELK1, FOXP3, ATF1, EP300, ELF1, GABPA, YY1, XRCC6, TFAP2C, YBX1, SP3, SP4, XRCC5	0
IRF1	YES	8	STAT3, STAT2, NFKB1, CREBBP, RELA, CIITA, STAT4, STAT1	0
RASSF1	YES	3	SP1, SP3, TP53	0
PIK3CA	YES	1	FOXO3	0
EGFR	YES	30	AR, BCL3, WWP1, NR3C2, TFAP2A, PGR, NFKB2, SP1, EGR1, PML, HDAC3, MTA1, BRCA1, WT1, VDR, HOXB7, JUN, TP53, RELA, LRRFIP1, NFKB1, STAT1, STAT3, YY1, YBX1, ESR1, JUNB, PPARG, CREBBP, TSG101	0
CASP8	YES	4	RUNX3, MEN1, DNMT1, CREB1	0
PARK2	YES	1	SIM2	0
FASLG	YES	17	SP1, MYC, CREM, EGR1, NFKB1, IRF1, EGR2, CEBPB, MAX, JUN, NR4A1, ATF2, RELA, CIITA, FOXO3, PPARG, PDCD11	1	IRF1
KRAS	YES	1	MYC	0
CYP2A6	YES	1	NFYA	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ERBB2	IRF1	No	4	CBL, STAT1, HSP90AA1, STUB1
ERBB2	SLC22A18	No	1	NRG1
ERBB2	RASSF1	No	2	CLNK, XPO1
ERBB2	PIK3CA	No	14	IL13RA2, IRS4, CRK, CBL, IRS1, PIK3R3, THRSP, PIK3R1, ERBB3, PIK3R2, ESR1, PSMC3IP, GRB2, STAT1
ERBB2	EGFR	Yes	94	RASA1, MAPK8IP1, PLCG1, EGFR, RIN2, HDAC6, PTK2, CD44, CTNNB1, ATP1A1, RIN1, SHC3, ABL1, ESRRB, STAT1, CBL, CDC37, TNS3, JAK1, ESR1, VAV2, JAK2, STUB1, FER, HSP90B1, ERRFI1, TNPO1, PIK3R1, APBB3, SH2D2A, CISH, HSP90AA1, IRS4, GRAP2, GRB2, IARS, SLA, DOK4, CRKL, EGF, NRG1, BMX, PIK3R3, PTK6, PIK3R2, SYK, ANKS1A, ANKS1B, SHC2, SOCS1, ERBB3, SH2D3A, SH2B3, NCK2, BLK, VAV1, DOK1, FGR, TFRC, EEF1G, DOK6, PLCG2, ABL2, AP2B1, IGF1R, VAV3, PTPN11, OSMR, USP2, XPO1, TLN1, CRK, CLNK, ERBB2, SLA2, MUC1, CD82, SHC1, KPNB1, LRIG1, SH3BGRL, PC, JUP, SRC, PAK1, STAT3, TGFA, APBB1, ITK, PTK2B, HSPA4, IRS1, MAPK8IP2, ERBB4
ERBB2	MAP3K8	No	2	HSP90AA1, XPO1
ERBB2	CASP8	No	8	IL13RA2, KLK5, ERRFI1, GLCE, LYPD3, PSMC3IP, PRDM14, USP2
ERBB2	PARK2	No	13	PLCG1, TFRC, PICK1, CTNNB1, HSP90B1, HSPA4, HSP90AA1, ABL1, ACTB, EGFR, DLG4, ESRRB, STUB1
ERBB2	FASLG	No	9	NCK2, ITK, TEC, CRK, PIK3R1, SRC, GRB2, GRAP2, FGR
ERBB2	BRAF	No	3	CCDC88A, CDC37, HSP90AA1
ERBB2	PPP2R1B	No	5	STAT3, STK24, EGFR, JAK2, CLTC
ERBB2	KRAS	No	2	THRSP, PIK3R2
IRF1	ERCC6	No	3	KAT2B, HIST1H3A, MDM2
IRF1	RASSF1	No	1	MDM2
IRF1	PIK3CA	No	2	CBL, STAT1
IRF1	EGFR	No	9	KEAP1, HSPA1A, BIRC3, CBL, HCFC1, HSP90AA1, STAT1, TRMT2A, STUB1
IRF1	MAP3K8	No	1	HSP90AA1
IRF1	CASP8	No	2	BIRC3, YBX1
IRF1	PARK2	No	5	HSPA1A, SET, HSP90AA1, STUB1, NPM1
IRF1	BRAF	No	2	HSPA1A, HSP90AA1
SLC22A18	EGFR	No	1	NRG1
ERCC6	RASSF1	No	3	MDM2, CUL4A, DDB1
ERCC6	PIK3CA	No	1	HDAC1
ERCC6	EGFR	No	5	UBC, SSBP1, CUL4B, RPA1, PCNA
ERCC6	CASP8	No	5	PARP1, UBC, COPS6, BAX, TP53
ERCC6	PARK2	No	5	UBC, SSBP1, PCNA, VCP, HNRNPU
ERCC6	PPP2R1B	No	1	HDAC1
RASSF1	PIK3CA	No	2	HRAS, ATR
RASSF1	EGFR	No	8	ATR, HUWE1, PRKDC, TUBB, XPO1, XPO6, CLNK, TUBG1
RASSF1	MAP3K8	No	1	XPO1
RASSF1	CASP8	No	1	RHOA
RASSF1	PARK2	No	6	CUL1, AURKA, TUBB, AURKB, CDC20, TUBG1
RASSF1	FASLG	No	1	RHOA
RASSF1	BRAF	No	1	HRAS
RASSF1	PPP2R1B	No	2	FBXW11, RASSF1
RASSF1	KRAS	No	2	BTRC, RASSF5
PIK3CA	EGFR	No	18	PIK3R3, TNFRSF1A, UMPS, CRK, CBL, ATR, IRS1, PIK3R1, PIK3R2, ERBB3, AKT1, IRS4, NTRK1, IRS2, GRB2, APPL1, ESR1, STAT1
PIK3CA	MAP3K8	No	2	CD40, AKT1
PIK3CA	CASP8	No	8	IL13RA2, TNFRSF1A, FASLG, BEX1, UMPS, PSMC3IP, IL24, SQSTM1
PIK3CA	PARK2	No	4	DDX5, RPS20, YWHAH, SQSTM1
PIK3CA	FASLG	Yes	5	CRK, LCK, GRB2, PIK3R1, TNFRSF1A
PIK3CA	BRAF	No	3	HRAS, YWHAH, AKT1
PIK3CA	PPP2R1B	No	1	HDAC1
PIK3CA	KRAS	Yes	4	THRSP, TNFSF13, IL24, PIK3R2
EGFR	MAP3K8	No	9	HSP90AA1, MAP2K4, AKT1, STIP1, RIPK1, XPO1, MAP3K14, TRAF2, NEDD4
EGFR	CASP8	No	18	TNFRSF1A, CASP1, TRAF2, MAPK8, TNFRSF10B, ERRFI1, BIRC2, BLM, RIPK1, CEBPB, HDAC7, BIRC3, UMPS, MAP1LC3A, UBC, MAP3K14, EZR, USP2
EGFR	PARK2	Yes	90	TXN, ABL1, SSBP1, EGFR, PSMD1, IKBKG, ATP5C1, TPM1, CTNNB1, EEF1A1, RPL4, PCNA, ESRRB, MTOR, CALR, PSMD4, HSD17B10, PRDX1, ATP5A1, PLK1, DDX47, PRKACA, STUB1, HSP90B1, BAG2, DNM1L, HSPA2, EPS15, HSPA9, GAPDH, HK1, UBE2G2, PSMA7, SFPQ, HSP90AA1, TUBA4A, UBASH3A, DNAJA1, ADRM1, RPL22, TUBB, SLC25A13, UBC, PLCG1, MAPT, HSPA1A, MATR3, TUBB6, TOMM22, HSPA5, AIFM1, APP, TUBB4B, TFRC, UCHL1, ATAD3B, TUBA1A, NDUFS3, OPA1, LRPPRC, ACTA2, CALU, CLPX, ATXN2, CHCHD3, PARK2, TPM3, NTPCR, RFC4, RCN2, HSP90AB1, ATP2B1, CDK5, HIST1H2AA, MDH1, PSMD2, ARRB1, TUBG1, SNCA, P4HB, UBASH3B, IGHG1, TRAF2, HK2, HSPA8, HADHB, HSPA4, HNRNPH1, TPM4, ARRB2
EGFR	FASLG	No	22	FN1, YES1, HCK, LYN, ITSN2, EZR, MAPK8, CRK, SNX9, NCK1, NCK2, TNFRSF10B, CLPX, SRC, GRAP2, FGR, TNFRSF1A, ITK, SH3GL3, DOCK4, PIK3R1, GRB2
EGFR	BRAF	No	16	HSP90AA1, HSPA9, HSPA8, SFN, HSPA1A, CDC37, MAP2K2, PRKCE, RAF1, NEDD4, AKT1, HSP90AB1, HSPA5, YWHAQ, YWHAB, YWHAZ
EGFR	PPP2R1B	Yes	17	MOB4, CAV1, RPN1, IKBKG, PRDX1, PPP2R5C, STAT3, PPP2R1B, PPP2R5E, PRKAA1, JAK2, EGFR, PPP2R1A, PPP2R2A, RAB18, DNAAF5, CDK1
EGFR	KRAS	No	11	CALM1, DDX47, RAP1GDS1, PML, PIK3R2, RAF1, DNAJA3, EEF1A1, LIMA1, ABCD3, APP
MAP3K8	CASP8	No	5	TRAF6, MAP3K14, CHUK, TRAF2, RIPK1
MAP3K8	PARK2	No	3	REL, TRAF2, HSP90AA1
MAP3K8	BRAF	No	4	HSP90AA1, MAP2K1, NEDD4, AKT1
MAP3K8	KRAS	No	1	TRAF6
CASP8	PARK2	No	11	BCL2, LRRK2, PDIA6, PARK7, MAPK1, VIM, CASP14, TRAF2, UBC, FIS1, SQSTM1
CASP8	FASLG	Yes	13	ARHGDIA, MAPK8, CASP8, CASP10, FAS, RHOA, TNFRSF10B, TNFRSF1A, CFLAR, MSN, EZR, BID, FADD
CASP8	BRAF	No	1	MAPK1
CASP8	PPP2R1B	No	2	PARK7, TNFAIP3
CASP8	KRAS	No	7	RALGDS, BCL2, QDPR, MAPK1, IL24, SERPINB5, TRAF6
PARK2	FASLG	No	1	CLPX
PARK2	BRAF	No	10	HSPA1A, HSPA8, YWHAE, YWHAH, MAPK1, HSPA9, HSP90AA1, LIMK1, HSP90AB1, HSPA5
PARK2	PPP2R1B	No	5	PRDX1, PARK7, IKBKG, EGFR, SLC25A3
PARK2	KRAS	No	8	HNRNPC, BCL2, MAPK1, ELAVL1, DDX47, EEF1A1, PSMA3, APP
FASLG	KRAS	No	2	SORBS3, PIK3CA
BRAF	KRAS	No	3	MAPK1, ARAF, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CASP8	KRAS	No	1	NOL3
PARK2	KRAS	No	1	PINK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
ERBB2	IRF1	No	-	10	PTGS2, STAT3, MAPK8, CCND1, MMP9, TP53, CD44, EGFR, UBC, STUB1
ERBB2	SLC22A18	No	-	1	UBC
ERBB2	ERCC6	No	-	2	UBC, TP53
ERBB2	RASSF1	No	-	2	MAPK8, TP53
ERBB2	PIK3CA	Yes	activation, binding	57	BCL2L1, EGFR, FIGF, TP53, RAC1, JAK2, SHC1, CTNND1, PIK3R2, PGF, PGR, PDGFB, GRB2, HGF, ITGA6, PTPN1, MAP2K1, JAK1, PTK2, ERBB3, CTNNB1, SOS1, VEGFC, PIK3CG, PDGFA, ESR1, ANGPT2, AR, HRAS, EFNB1, NOTCH1, CDH1, PLCG2, PIK3CB, RHOG, PIK3R3, RHOA, SRC, CBLB, MYC, STAT3, KRAS, PTPN11, IGF1R, CBLC, CBL, INS, PIK3R1, ERBB4, IGF1, EGF, PLCG1, PIK3CD, CCND1, VEGFA, PIK3R5, RAC3
ERBB2	EGFR	Yes	activation, binding	115	EREG, ADAM17, PLCG1, TP53, MMP9, SHC2, SOS1, PDGFB, EYA2, NOTCH3, NCOA3, PTK2, CD44, TFF1, CTNNB1, RHBDL3, PDGFA, SLC3A2, UBA52, SHC3, CBLB, PTPRK, CBL, CDC37, INS, JAK1, ESR1, RNF41, BCL2L1, NOTCH4, GRAPL, JAK2, RHBDL2, DCN, UBB, STUB1, PTGS2, HGF, HSP90B1, ERRFI1, PIK3R1, RHBDL1, IGF1, MCL1, AR, HSP90AA1, CDH1, PIK3R3, EYA4, GRAP2, GRB2, IQSEC1, NRG4, IGF1R, SPRY2, UBC, VEGFC, CCND1, HIF1A, PTPN1, NRG2, PTK6, PIK3R2, HBEGF, IQGAP1, PIK3R5, KRAS, ERBB3, EYA1, LEP, ARHGEF12, GRAP, HRAS, NOTCH1, IL8, BTC, VEGFA, VEGFB, RHOB, RAC1, TFF3, TFF2, PLCG2, PIK3CD, PDGFC, PDGFD, PTPN11, PGF, FIGF, BIRC5, CTNND1, PIK3CG, ANGPT2, MUC1, RPS27A, PIK3CA, SHC4, DNAJA3, SHC1, PRKACA, LRIG1, EGF, JUP, SRC, STAT3, ITGA6, TGFA, PTK2B, HSPA4, PIK3CB, CBLC, IL6, MYC, RHOA, ERBB4
ERBB2	MAP3K8	No	-	3	MAP2K1, TP53, HSP90AA1
ERBB2	PARK2	No	-	9	BCL2L1, MCL1, HSPA4, RPS27A, HSP90AA1, STUB1, UBC, RNF41, HIF1A
ERBB2	BRAF	No	-	11	IQGAP1, MCL1, HRAS, CDC37, HSP90AA1, SPRY2, KRAS, PIN1, UBC, PRKACA, MAP2K1
ERBB2	PPP2R1B	No	-	1	MAP2K1
ERBB2	MXRA5	No	-	1	HSP90AA1
ERBB2	KRAS	Yes	activation, binding	29	BCL2L1, EGFR, PTPN11, TP53, SHC2, PTK2, PIK3CG, HBEGF, CCND1, SOS1, ERBB3, SHC1, SLC3A2, HRAS, HSP90AA1, UBC, SHC3, IL8, SRC, VEGFA, GRB2, NOTCH1, PIK3CB, SPRY2, PIK3CA, EGF, PIK3CD, MAP2K1, ERBB4
ERBB2	CYP2A6	No	-	1	BIRC5
IRF1	SLC22A18	No	-	1	UBC
IRF1	ERCC6	No	-	5	KAT2B, UBC, POLR2A, TP53, PCNA
IRF1	RASSF1	No	-	4	CDKN1A, MDM2, MAPK8, TP53
IRF1	PIK3CA	No	-	8	STAT3, IL4, NR3C1, CCND1, RELA, IFNG, TP53, EGFR
IRF1	EGFR	Yes	activation, binding	21	PTGS2, STAT3, STAT5A, PCNA, EGR1, TP53, CD44, BIRC3, SOCS3, IFNA1, UBC, JUN, MDM2, STAT5B, MMP9, TERT, IFNA2, GBP1, SOCS1, CCND1, STUB1
IRF1	MAP3K8	No	-	3	CHUK, TP53, RELA
IRF1	PARK2	No	-	3	UBC, PCNA, STUB1
IRF1	BRAF	No	-	1	UBC
IRF1	PPP2R1B	No	-	1	RELA
IRF1	KRAS	No	-	7	CCND1, TP53, JUN, NPM1, EGFR, UBC, NCAM1
SLC22A18	ERCC6	No	-	1	UBC
SLC22A18	EGFR	No	-	1	UBC
SLC22A18	PARK2	No	-	1	UBC
SLC22A18	BRAF	No	-	1	UBC
SLC22A18	KRAS	No	-	1	UBC
ERCC6	RASSF1	No	-	1	TP53
ERCC6	PIK3CA	No	-	1	TP53
ERCC6	EGFR	No	-	4	ERCC1, UBC, TP53, PCNA
ERCC6	MAP3K8	No	-	1	TP53
ERCC6	PARK2	No	-	2	UBC, PCNA
ERCC6	BRAF	No	-	1	UBC
ERCC6	KRAS	No	-	2	UBC, TP53
RASSF1	PIK3CA	No	-	1	TP53
RASSF1	EGFR	No	-	3	TP53, MDM2, SFN
RASSF1	MAP3K8	No	-	1	TP53
RASSF1	BRAF	No	-	1	SFN
RASSF1	PPP2R1B	No	-	1	STK3
RASSF1	KRAS	No	-	2	BTRC, TP53
PIK3CA	EGFR	Yes	activation	92	KITLG, PTPN1, TP53, CDC42, PDGFB, CBLB, PDGFRB, PTK2, FGR, CTNNB1, PDGFA, PIK3CB, PDGFRA, PRKCA, CBL, MTOR, INS, JAK1, ESR1, VAV2, PIK3R5, BCL2L1, JAK2, PGF, ANGPT2, ITGA1, ITGA6, RHOA, PIK3R1, IGF1, HGF, AR, CDH1, PIK3R3, ITGB4, GRB2, IGF1R, EGF, VEGFC, PIK3CD, PLCG1, RAC1, CREB1, CSK, CTNNA1, CCND1, KRAS, MET, ERBB3, SH2D3A, LCK, HRAS, NOTCH1, VAV1, PTEN, PXN, VEGFA, YES1, CTNND1, GNAI3, NTF3, PLCG2, EFNA1, PTPN11, FIGF, HCK, PLAU, LYN, IRS1, PIK3CG, GNAI1, CRKL, ANGPT1, ITGB1, CRK, SOS1, ERBB2, PIK3R2, SHC1, YWHAZ, SLC9A3R1, TRAF2, SRC, FYN, NFKB1, GAB1, STAT3, ARF6, CBLC, IRS2, MYC, ERBB4
PIK3CA	MAP3K8	No	-	10	AKT2, TRAF2, MAP2K1, RELA, MAP2K2, TP53, AKT3, AKT1, IL2, NFKB1
PIK3CA	PARK2	No	-	3	BCL2L1, BECN1, TRAF2
PIK3CA	BRAF	No	-	16	MAP2K2, KRAS, RAP1A, RPS6KA2, CRK, HRAS, RRAS, PRKCD, RAF1, AKT1, PRKCA, RPS6KB2, RAP1B, MRAS, YWHAZ, MAP2K1
PIK3CA	PPP2R1B	No	-	12	MAP2K2, AKT1, PRKCI, F11R, MAP2K1, RELA, AKT2, AKT3, RPS6KB1, PRKCA, RPS6KB2, NFKB1
PIK3CA	KRAS	Yes	activation, binding	37	BCL2L1, EGFR, RET, MAP2K2, TP53, SOS1, PIK3CG, TEK, VEGFA, ANGPT1, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, RAF1, SHC1, AKT2, KIT, HRAS, RPS6KB1, GRB2, AKT1, SRC, FYN, FRS2, YES1, NOTCH1, PTPN11, PIK3CB, MTOR, IRS2, EGF, IRS1, PIK3CD, CCND1, ERBB4
EGFR	MAP3K8	No	-	8	HSP90AA1, TRAF2, NFKB1, TRAF6, TP53, HSP90AB1, ABI1, PLCB3
EGFR	PARK2	No	-	18	EPS15, BCL2L1, HSPA8, PCNA, MCL1, GAPDH, HSPA4, RPS27A, HSP90AA1, ABL1, NEDD4L, HIF1A, TRAF2, UBC, RNF41, SH3GL2, STUB1, UBE2D2
EGFR	BRAF	No	-	19	IQGAP1, KRAS, HSP90AB1, MCL1, CRK, CDC37, HRAS, PRKCB, MAPK1, PPP2CA, SPRY2, UBC, HSP90AA1, PRKCA, PPP2R1A, PRKACA, YWHAQ, SFN, YWHAZ
EGFR	PPP2R1B	No	-	6	PRKCB, MAPK1, PPP2CA, PRKCA, PPP2R2A, NFKB1
EGFR	MXRA5	No	-	2	HSP90AA1, HSP90AB1
EGFR	KRAS	Yes	activation, binding	50	BCL2L1, RASA1, CTGF, BMP4, PTPN11, NT5E, SPHK1, SHC2, PIK3CG, HBEGF, LGALS3, FYN, GRB2, ANGPT1, CCND1, PPP2CA, PTK2, ERBB2, ERBB3, SOS1, MAPK14, LGALS1, SHC3, CALM1, SLC3A2, HRAS, HSP90AA1, UBC, JUN, TP53, ABL1, SRC, BCL2L11, SHC1, YES1, NOTCH1, NCL, MAPK1, PIK3CB, MTOR, SPRY2, IL8, ERBB4, IRS2, PIK3CA, EGF, IRS1, PIK3CD, VEGFA, TSG101
EGFR	CYP2A6	No	-	1	BIRC5
MAP3K8	PARK2	No	-	3	REL, TRAF2, HSP90AA1
MAP3K8	BRAF	No	-	6	MAP2K2, HSP90AB1, MAP2K1, HSP90AA1, KSR1, AKT1
MAP3K8	PPP2R1B	No	-	7	AKT2, RELA, MAP2K1, MAP2K2, AKT3, AKT1, NFKB1
MAP3K8	MXRA5	No	-	2	HSP90AA1, HSP90AB1
MAP3K8	KRAS	No	-	7	HSP90AA1, MAP2K2, MAP2K1, AKT2, KSR1, TP53, AKT1
PARK2	BRAF	No	-	3	UBC, MCL1, HSP90AA1
PARK2	MXRA5	No	-	1	HSP90AA1
PARK2	KRAS	No	-	5	UBC, BCL2L1, HSP90AA1, ABL1, BCL2
BRAF	PPP2R1B	No	-	11	MAP2K2, AKT1, MAPK3, MAP2K1, PRKCB, MAPK1, PPP2CA, PPP2R2B, PRKCA, RPS6KB2, PRKCG
BRAF	MXRA5	No	-	2	HSP90AA1, HSP90AB1
BRAF	KRAS	Yes	activation, binding	16	MAP2K2, RAF1, ARAF, MAPK1, HRAS, MAPK3, PPP2CA, SPRY2, CNKSR3, KSR2, HSP90AA1, AKT1, UBC, MAP2K1, YWHAB, KSR1
PPP2R1B	KRAS	No	-	8	AKT2, MAPK3, MAP2K1, MAPK1, MAP2K2, PPP2CA, RPS6KB1, AKT1
MXRA5	KRAS	No	-	1	HSP90AA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
ERBB2	EGFR	Yes	EGFR-containing signaling complex	2	PIK3C2B, PIK3C2A
ERBB2	PARK2	No	-	1	EGFR
EGFR	PARK2	Yes	PARK2-EPS15-EGFR	1	EPS15
MAP3K8	CASP8	No	-	1	CHUK
BRAF	KRAS	No	-	1	RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
ERBB2	EGFR	Yes	2	ERBB2, EGFR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	8	KRAS, CASP8, BRAF, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
Proteoglycans in cancer	hsa05205	5.02	6	BRAF, KRAS, ERBB2, PIK3CA, EGFR, FASLG
Non-small cell lung cancer	hsa05223	6.88	6	BRAF, KRAS, ERBB2, PIK3CA, EGFR, RASSF1
Hepatitis C	hsa05160	5.68	6	IRF1, PPP2R1B, KRAS, EGFR, PIK3CA, BRAF
Bladder cancer	hsa05219	7.38	5	ERBB2, KRAS, EGFR, RASSF1, BRAF
Pancreatic cancer	hsa05212	6.56	5	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Endometrial cancer	hsa05213	6.81	5	ERBB2, KRAS, EGFR, PIK3CA, BRAF
MicroRNAs in cancer	hsa05206	5.38	5	ERBB2, KRAS, EGFR, RASSF1, PIK3CA
Prostate cancer	hsa05215	6.11	5	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Ras signaling pathway	hsa04014	4.9	5	FASLG, EGFR, KRAS, PIK3CA, RASSF1
ErbB signaling pathway	hsa04012	6.15	5	ERBB2, KRAS, EGFR, PIK3CA, BRAF
FoxO signaling pathway	hsa04068	5.63	5	EGFR, KRAS, PIK3CA, FASLG, BRAF
MAPK signaling pathway	hsa04010	4.63	5	MAP3K8, KRAS, FASLG, EGFR, BRAF
PI3K-Akt signaling pathway	hsa04151	4.21	5	PPP2R1B, EGFR, KRAS, PIK3CA, FASLG
Melanoma	hsa05218	6.56	4	BRAF, KRAS, EGFR, PIK3CA
Natural killer cell mediated cytotoxicity	hsa04650	5.53	4	BRAF, KRAS, FASLG, PIK3CA
Glioma	hsa05214	6.66	4	BRAF, KRAS, EGFR, PIK3CA
Chagas disease (American trypanosomiasis)	hsa05142	5.99	4	FASLG, CASP8, PPP2R1B, PIK3CA
Rap1 signaling pathway	hsa04015	4.97	4	BRAF, KRAS, EGFR, PIK3CA
Neurotrophin signaling pathway	hsa04722	5.78	4	BRAF, KRAS, FASLG, PIK3CA
Central carbon metabolism in cancer	hsa05230	6.7	4	ERBB2, KRAS, EGFR, PIK3CA
Focal adhesion	hsa04510	4.92	4	ERBB2, EGFR, PIK3CA, BRAF
Hepatitis B	hsa05161	5.52	4	KRAS, CASP8, FASLG, PIK3CA
Regulation of actin cytoskeleton	hsa04810	4.9	4	BRAF, KRAS, EGFR, PIK3CA
Renal cell carcinoma	hsa05211	6.6	3	BRAF, KRAS, PIK3CA
Acute myeloid leukemia	hsa05221	6.74	3	BRAF, KRAS, PIK3CA
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	3	CASP8, FASLG, PIK3CA
Oxytocin signaling pathway	hsa04921	5.4	3	KRAS, EGFR, PIK3CA
Chronic myeloid leukemia	hsa05220	6.48	3	BRAF, KRAS, PIK3CA
Toll-like receptor signaling pathway	hsa04620	6.0	3	MAP3K8, CASP8, PIK3CA
Viral carcinogenesis	hsa05203	5.08	3	KRAS, CASP8, PIK3CA
T cell receptor signaling pathway	hsa04660	6.01	3	MAP3K8, KRAS, PIK3CA
TNF signaling pathway	hsa04668	5.96	3	MAP3K8, CASP8, PIK3CA
Insulin signaling pathway	hsa04910	5.55	3	BRAF, KRAS, PIK3CA
Prolactin signaling pathway	hsa04917	6.6	3	IRF1, KRAS, PIK3CA
Progesterone-mediated oocyte maturation	hsa04914	6.18	3	BRAF, KRAS, PIK3CA
Estrogen signaling pathway	hsa04915	6.11	3	KRAS, EGFR, PIK3CA
HIF-1 signaling pathway	hsa04066	5.9	3	ERBB2, EGFR, PIK3CA
Apoptosis	hsa04210	6.23	3	CASP8, FASLG, PIK3CA
Chemokine signaling pathway	hsa04062	5.19	3	BRAF, KRAS, PIK3CA
Colorectal cancer	hsa05210	6.52	3	BRAF, KRAS, PIK3CA
Long-term depression	hsa04730	6.74	3	BRAF, KRAS, PPP2R1B
Choline metabolism in cancer	hsa05231	6.09	3	KRAS, EGFR, PIK3CA
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	2	KRAS, PIK3CA
Calcium signaling pathway	hsa04020	5.22	2	ERBB2, EGFR
Thyroid cancer	hsa05216	7.48	2	BRAF, KRAS
cAMP signaling pathway	hsa04024	5.05	2	BRAF, PIK3CA
Tight junction	hsa04530	5.53	2	KRAS, PPP2R1B
Long-term potentiation	hsa04720	6.64	2	BRAF, KRAS
Cholinergic synapse	hsa04725	5.88	2	KRAS, PIK3CA
Serotonergic synapse	hsa04726	5.84	2	BRAF, KRAS
Cytokine-cytokine receptor interaction	hsa04060	4.67	2	EGFR, FASLG
Aldosterone-regulated sodium reabsorption	hsa04960	7.41	2	KRAS, PIK3CA
Herpes simplex infection	hsa05168	5.08	2	CASP8, FASLG
Toxoplasmosis	hsa05145	5.71	2	CASP8, PIK3CA
Influenza A	hsa05164	5.21	2	FASLG, PIK3CA
HTLV-I infection	hsa05166	4.59	2	KRAS, PIK3CA
Measles	hsa05162	5.6	2	FASLG, PIK3CA
Gap junction	hsa04540	6.24	2	KRAS, EGFR
VEGF signaling pathway	hsa04370	6.77	2	KRAS, PIK3CA
GnRH signaling pathway	hsa04912	6.18	2	KRAS, EGFR
B cell receptor signaling pathway	hsa04662	6.52	2	KRAS, PIK3CA
Adherens junction	hsa04520	6.26	2	ERBB2, EGFR
Hippo signaling pathway	hsa04390	5.37	2	PPP2R1B, RASSF1
Thyroid hormone signaling pathway	hsa04919	5.82	2	KRAS, PIK3CA
AMPK signaling pathway	hsa04152	5.8	2	PPP2R1B, PIK3CA
mTOR signaling pathway	hsa04150	6.72	2	BRAF, PIK3CA
Dorso-ventral axis formation	hsa04320	8.01	2	KRAS, EGFR
Alcoholism	hsa05034	5.59	2	BRAF, KRAS
Fc epsilon RI signaling pathway	hsa04664	6.6	2	KRAS, PIK3CA
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	PPP2R1B, PIK3CA

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Pertussis (hsa05133)	NEW	6.46	0.026	IRF1, CASP8, FASLG, EGFR
Melanoma (hsa05218)	-	6.56	0.002	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Bladder cancer (hsa05219)	-	7.38	0.0	ERBB2, KRAS, EGFR, RASSF1, BRAF
Acute myeloid leukemia (hsa05221)	-	6.74	0.042	BRAF, KRAS, PIK3CA
Infectious diseases: Viral	NEW	3.29	0.009	KRAS, CASP8, IRF1, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.028	CASP8, BRAF, PIK3CA, ERBB2, KRAS, EGFR, FASLG
Renal cell carcinoma (hsa05211)	-	6.6	0.005	BRAF, KRAS, EGFR, PIK3CA
Endometrial cancer (hsa05213)	-	6.81	0.0	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Glioma (hsa05214)	-	6.66	0.001	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Prostate cancer (hsa05215)	-	6.11	0.001	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Nervous system	NEW	3.77	0.022	KRAS, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
Neurotrophin signaling pathway (hsa04722)	-	5.78	0.015	BRAF, KRAS, ERBB2, PIK3CA, EGFR, FASLG
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.001	ERBB2, KRAS, EGFR, PIK3CA
FoxO signaling pathway (hsa04068)	-	5.63	0.0	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
HIF-1 signaling pathway (hsa04066)	-	5.9	0.048	ERBB2, CASP8, EGFR, PIK3CA
Chemokine signaling pathway (hsa04062)	-	5.19	0.037	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Oxytocin signaling pathway (hsa04921)	-	5.4	0.022	EGFR, KRAS, PARK2, PPP2R1B, PIK3CA
Cancers: Overview	NEW	2.72	0.006	CYP2A6, KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
Chagas disease (American trypanosomiasis) (hsa05142)	-	5.99	0.003	PPP2R1B, IRF1, CASP8, FASLG, PIK3CA
Pancreatic cancer (hsa05212)	-	6.56	0.0	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Cytokine-cytokine receptor interaction (hsa04060)	-	4.67	0.026	CASP8, IRF1, PIK3CA, ERBB2, EGFR, FASLG
Infectious diseases: Parasitic	NEW	4.46	0.001	KRAS, CASP8, IRF1, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
Toxoplasmosis (hsa05145)	-	5.71	0.007	KRAS, IRF1, CASP8, FASLG, PIK3CA
Fc gamma R-mediated phagocytosis (hsa04666)	NEW	6.21	0.015	ERBB2, KRAS, EGFR, PIK3CA
Regulation of actin cytoskeleton (hsa04810)	-	4.9	0.01	BRAF, KRAS, ERBB2, PIK3CA, EGFR, FASLG
Hepatitis C (hsa05160)	-	5.68	0.0	IRF1, PPP2R1B, KRAS, EGFR, PIK3CA, BRAF
Hepatitis B (hsa05161)	-	5.52	0.0	CASP8, IRF1, KRAS, PIK3CA, EGFR, FASLG
Measles (hsa05162)	-	5.6	0.009	IRF1, CASP8, EGFR, FASLG, PIK3CA
Chronic myeloid leukemia (hsa05220)	-	6.48	0.0	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Cancers: Specific types	NEW	4.1	0.012	KRAS, CASP8, BRAF, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
Endocrine and metabolic diseases	NEW	4.75	0.034	CASP8, IRF1, PIK3CA, ERBB2, EGFR, FASLG
Alcoholism (hsa05034)	-	5.59	0.001	BRAF, PARK2, KRAS, ERBB2, PIK3CA, EGFR
Substance dependence	NEW	4.77	0.022	BRAF, PARK2, KRAS, ERBB2, PIK3CA, EGFR
Proteoglycans in cancer (hsa05205)	-	5.02	0.006	BRAF, KRAS, ERBB2, PIK3CA, EGFR, FASLG
Estrogen signaling pathway (hsa04915)	-	6.11	0.035	ERBB2, KRAS, EGFR, PIK3CA
MicroRNAs in cancer (hsa05206)	-	5.38	0.002	ERBB2, KRAS, EGFR, RASSF1, PIK3CA
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.0	CASP8, IRF1, PIK3CA, EGFR, MAP3K8, FASLG
Pathways in cancer (hsa05200)	-	3.98	0.009	KRAS, CASP8, BRAF, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
Viral carcinogenesis (hsa05203)	-	5.08	0.007	CASP8, IRF1, KRAS, ERBB2, PIK3CA, EGFR
T cell receptor signaling pathway (hsa04660)	-	6.01	0.0	CASP8, MAP3K8, KRAS, PIK3CA, EGFR, FASLG
Signal transduction	NEW	2.06	0.037	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
Insulin signaling pathway (hsa04910)	-	5.55	0.016	ERBB2, KRAS, EGFR, PIK3CA, BRAF
Ras signaling pathway (hsa04014)	-	4.9	0.0	KRAS, MAP3K8, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
Non-small cell lung cancer (hsa05223)	-	6.88	0.0	BRAF, KRAS, ERBB2, PIK3CA, EGFR, RASSF1
Prolactin signaling pathway (hsa04917)	-	6.6	0.0	ERBB2, KRAS, EGFR, IRF1, PIK3CA
Progesterone-mediated oocyte maturation (hsa04914)	-	6.18	0.021	BRAF, KRAS, EGFR, PIK3CA
MAPK signaling pathway (hsa04010)	-	4.63	0.0	KRAS, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
TNF signaling pathway (hsa04668)	-	5.96	0.003	MAP3K8, CASP8, EGFR, PIK3CA, FASLG
Cell motility	NEW	4.9	0.01	BRAF, KRAS, ERBB2, PIK3CA, EGFR, FASLG
Long-term depression (hsa04730)	-	6.74	0.042	BRAF, KRAS, PPP2R1B
PI3K-Akt signaling pathway (hsa04151)	-	4.21	0.025	KRAS, IRF1, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
Human Diseases	NEW	1.54	0.018	CYP2A6, KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
Immune system	NEW	2.92	0.03	CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
Rap1 signaling pathway (hsa04015)	-	4.97	0.015	BRAF, KRAS, ERBB2, PIK3CA, EGFR, RASSF1
Autoimmune thyroid disease (hsa05320)	NEW	6.62	0.005	IRF1, EGFR, FASLG, PIK3CA
Tuberculosis (hsa05152)	NEW	5.17	0.0	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, FASLG
Circulatory system	NEW	4.63	0.028	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
ErbB signaling pathway (hsa04012)	-	6.15	0.0	ERBB2, KRAS, EGFR, PIK3CA, BRAF

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Immune System	R-HSA-168256	2.37	10	KRAS, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8
Innate Immune System	R-HSA-168249	3.17	9	KRAS, CASP8, IRF1, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	8	KRAS, IRF1, PPP2R1B, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
Signal Transduction	R-HSA-162582	1.78	8	KRAS, CASP8, BRAF, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
Adaptive Immune System	R-HSA-1280218	3.19	7	KRAS, MAP3K8, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR
Signaling by Interleukins	R-HSA-449147	4.71	7	KRAS, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Interleukin-2 signaling	R-HSA-451927	5.05	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
IGF1R signaling cascade	R-HSA-2428924	4.85	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Downstream signal transduction	R-HSA-186763	4.65	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by ERBB4	R-HSA-1236394	4.7	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by Insulin receptor	R-HSA-74752	4.73	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Insulin receptor signalling cascade	R-HSA-74751	4.85	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signalling by NGF	R-HSA-166520	4.23	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by VEGF	R-HSA-194138	4.66	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
IRS-mediated signalling	R-HSA-112399	4.87	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by FGFR4	R-HSA-5654743	4.69	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by FGFR3	R-HSA-5654741	4.69	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by FGFR	R-HSA-190236	4.67	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Interleukin receptor SHC signaling	R-HSA-912526	5.09	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by SCF-KIT	R-HSA-1433557	4.73	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by PDGF	R-HSA-186797	4.53	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
DAP12 signaling	R-HSA-2424491	4.64	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by EGFR	R-HSA-177929	4.59	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by GPCR	R-HSA-372790	2.68	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by FGFR2	R-HSA-5654738	4.68	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by FGFR1	R-HSA-5654736	4.69	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
DAP12 interactions	R-HSA-2172127	4.56	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by ERBB2	R-HSA-1227986	4.66	6	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Signaling by Leptin	R-HSA-2586552	5.1	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Frs2-mediated activation	R-HSA-170968	5.12	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Disease	R-HSA-1643685	3.33	5	ERBB2, KRAS, EGFR, PPP2R1B, PIK3CA
RAF/MAP kinase cascade	R-HSA-5673001	5.15	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
MAPK family signaling cascades	R-HSA-5683057	4.89	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
FCERI mediated MAPK activation	R-HSA-2871796	4.32	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
SOS-mediated signalling	R-HSA-112412	5.15	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Developmental Biology	R-HSA-1266738	3.48	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Diseases of signal transduction	R-HSA-5663202	4.89	5	ERBB2, KRAS, EGFR, PPP2R1B, PIK3CA
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Signalling to RAS	R-HSA-167044	5.08	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
SHC1 events in EGFR signaling	R-HSA-180336	5.15	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Prolonged ERK activation events	R-HSA-169893	5.11	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Signalling to ERKs	R-HSA-187687	5.04	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
GRB2 events in EGFR signaling	R-HSA-179812	5.15	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
ARMS-mediated activation	R-HSA-170984	5.12	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Axon guidance	R-HSA-422475	3.93	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	5	ERBB2, KRAS, EGFR, PPP2R1B, BRAF
Hemostasis	R-HSA-109582	3.98	4	IRF1, KRAS, PPP2R1B, PIK3CA
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	4	ERBB2, KRAS, EGFR, PIK3CA
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	4	ERBB2, KRAS, EGFR, PIK3CA
TRIF-mediated TLR3/TLR4 signaling	R-HSA-937061	6.47	3	MAP3K8, CASP8, PPP2R1B
PI3K/AKT activation	R-HSA-198203	6.32	3	ERBB2, EGFR, PIK3CA
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11	3	MAP3K8, CASP8, PPP2R1B
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05	3	ERBB2, EGFR, PIK3CA
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	3	ERBB2, EGFR, PIK3CA
Metabolism	R-HSA-1430728	2.34	3	CYP2A6, PPP2R1B, PIK3CA
GAB1 signalosome	R-HSA-180292	6.31	3	ERBB2, EGFR, PIK3CA
RAF activation	R-HSA-5673000	8.34	3	BRAF, KRAS, PPP2R1B
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	3	ERBB2, EGFR, PIK3CA
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	3	KRAS, EGFR, PIK3CA
PIP3 activates AKT signaling	R-HSA-1257604	6.37	3	ERBB2, EGFR, PIK3CA
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	3	ERBB2, EGFR, PIK3CA
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	3	ERBB2, EGFR, PIK3CA
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.47	3	MAP3K8, CASP8, PPP2R1B
Toll-Like Receptors Cascades	R-HSA-168898	5.91	3	MAP3K8, CASP8, PPP2R1B
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	3	KRAS, EGFR, PIK3CA
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	3	KRAS, EGFR, PIK3CA
MyD88-independent TLR3/TLR4 cascade	R-HSA-166166	6.47	3	MAP3K8, CASP8, PPP2R1B
Signaling by EGFR in Cancer	R-HSA-1643713	8.73	3	KRAS, EGFR, PIK3CA
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	3	ERBB2, EGFR, PIK3CA
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	3	ERBB2, EGFR, PIK3CA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73	3	KRAS, EGFR, PIK3CA
Costimulation by the CD28 family	R-HSA-388841	6.56	3	MAP3K8, PPP2R1B, PIK3CA
Negative regulation of MAPK pathway	R-HSA-5675221	7.66	3	BRAF, KRAS, PPP2R1B
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	3	ERBB2, EGFR, PIK3CA
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	3	ERBB2, EGFR, PIK3CA
Activated TLR4 signalling	R-HSA-166054	6.27	3	MAP3K8, CASP8, PPP2R1B
PLCG1 events in ERBB2 signaling	R-HSA-1251932	7.85	2	ERBB2, EGFR
Signaling by FGFR3 in disease	R-HSA-5655332	8.52	2	KRAS, PIK3CA
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51	2	MAP3K8, PPP2R1B
MAP2K and MAPK activation	R-HSA-5674135	7.66	2	BRAF, KRAS
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.73	2	MAP3K8, PPP2R1B
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	R-HSA-168928	6.7	2	IRF1, CASP8
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.73	2	MAP3K8, PPP2R1B
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	2	KRAS, PIK3CA
CD28 co-stimulation	R-HSA-389356	7.98	2	MAP3K8, PIK3CA
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59	2	MAP3K8, PIK3CA
Death Receptor Signalling	R-HSA-73887	8.52	2	CASP8, FASLG
Signaling by FGFR in disease	R-HSA-1226099	7.49	2	KRAS, PIK3CA
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	2	KRAS, CASP8
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56	2	MAP3K8, PPP2R1B
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.68	2	MAP3K8, PPP2R1B
MAP kinase activation in TLR cascade	R-HSA-450294	7.28	2	MAP3K8, PPP2R1B
Signaling by FGFR1 in disease	R-HSA-5655302	7.81	2	KRAS, PIK3CA
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	KRAS, PIK3CA
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51	2	MAP3K8, PPP2R1B
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.72	2	MAP3K8, PPP2R1B
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.73	2	MAP3K8, PPP2R1B
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.68	2	MAP3K8, PPP2R1B
Tie2 Signaling	R-HSA-210993	8.81	2	KRAS, PIK3CA
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56	2	MAP3K8, PPP2R1B
EGFR Transactivation by Gastrin	R-HSA-2179392	9.81	2	KRAS, EGFR
FasL/ CD95L signaling	R-HSA-75157	10.66	2	CASP8, FASLG
Signaling by FGFR2 in disease	R-HSA-5655253	8.23	2	KRAS, PIK3CA
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.62	2	MAP3K8, PPP2R1B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Signaling by PDGF (R-HSA-186797)	-	4.53	0.035	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Immune System (R-HSA-168256)	-	2.37	0.001	KRAS, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
FCERI mediated MAPK activation (R-HSA-2871796)	-	4.32	0.013	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by FGFR3 in disease (R-HSA-5655332)	-	8.52	0.003	KRAS, EGFR, PIK3CA
Signaling by Interleukins (R-HSA-449147)	-	4.71	0.0	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF
Toll Like Receptor 2 (TLR2) Cascade (R-HSA-181438)	-	6.51	0.001	PPP2R1B, ERBB2, CASP8, MAP3K8, EGFR
GRB2 events in ERBB2 signaling (R-HSA-1963640)	-	5.15	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Frs2-mediated activation (R-HSA-170968)	-	5.12	0.009	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Cytokine Signaling in Immune system (R-HSA-1280215)	-	3.74	0.0	KRAS, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, EGFR, MAP3K8, FASLG
FasL/ CD95L signaling (R-HSA-75157)	-	10.66	0.008	CASP8, FASLG
Downstream signal transduction (R-HSA-186763)	-	4.65	0.016	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
IRS-related events triggered by IGF1R (R-HSA-2428928)	-	4.85	0.006	KRAS, BRAF, PIK3CA, ERBB2, PPP2R1B, EGFR, MAP3K8
Signaling by ERBB4 (R-HSA-1236394)	-	4.7	0.013	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
DAP12 interactions (R-HSA-2172127)	-	4.56	0.023	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by Insulin receptor (R-HSA-74752)	-	4.73	0.002	KRAS, BRAF, PIK3CA, ERBB2, PPP2R1B, EGFR, MAP3K8
Adaptive Immune System (R-HSA-1280218)	-	3.19	0.004	KRAS, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, IRF1, BRAF, FASLG
RAF activation (R-HSA-5673000)	-	8.34	0.007	BRAF, KRAS, PPP2R1B
RAF/MAP kinase cascade (R-HSA-5673001)	-	5.15	0.008	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815)	-	8.73	0.001	KRAS, EGFR, PIK3CA
Downstream signaling of activated FGFR1 (R-HSA-5654687)	-	4.71	0.012	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
MAPK family signaling cascades (R-HSA-5683057)	-	4.89	0.018	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signalling by NGF (R-HSA-166520)	-	4.23	0.013	KRAS, CASP8, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, FASLG
Signaling by VEGF (R-HSA-194138)	-	4.66	0.002	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signalling to p38 via RIT and RIN (R-HSA-187706)	-	5.12	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907)	-	4.26	0.012	KRAS, BRAF, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
EGFR Transactivation by Gastrin (R-HSA-2179392)	-	9.81	0.03	KRAS, EGFR
IRS-mediated signalling (R-HSA-112399)	-	4.87	0.001	KRAS, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF
Toll-Like Receptors Cascades (R-HSA-168898)	-	5.91	0.001	CASP8, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR
FRS-mediated FGFR2 signaling (R-HSA-5654700)	-	5.14	0.008	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
FRS-mediated FGFR4 signaling (R-HSA-5654712)	-	5.14	0.008	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
FRS-mediated FGFR3 signaling (R-HSA-5654706)	-	5.14	0.008	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Constitutive Signaling by EGFRvIII (R-HSA-5637810)	-	9.08	0.0	KRAS, EGFR, PIK3CA
Signaling by EGFRvIII in Cancer (R-HSA-5637812)	-	9.08	0.0	KRAS, EGFR, PIK3CA
Signaling by EGFR in Cancer (R-HSA-1643713)	-	8.73	0.001	KRAS, EGFR, PIK3CA
Insulin receptor signalling cascade (R-HSA-74751)	-	4.85	0.006	KRAS, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF
Signaling by FGFR4 (R-HSA-5654743)	-	4.69	0.013	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Downstream signaling of activated FGFR3 (R-HSA-5654708)	-	4.71	0.012	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by FGFR3 (R-HSA-5654741)	-	4.69	0.013	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192)	-	4.85	0.006	KRAS, BRAF, PIK3CA, ERBB2, PPP2R1B, EGFR, MAP3K8
VEGFA-VEGFR2 Pathway (R-HSA-4420097)	-	4.7	0.011	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Diseases of signal transduction (R-HSA-5663202)	-	4.89	0.018	ERBB2, KRAS, EGFR, PPP2R1B, PIK3CA
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)	-	5.59	0.044	ERBB2, KRAS, EGFR, PIK3CA
Signaling by FGFR (R-HSA-190236)	-	4.67	0.014	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
G alpha (12/13) signalling events (R-HSA-416482)	NEW	6.75	0.012	FASLG, ERBB2, EGFR, PIK3CA
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202)	-	4.03	0.029	BRAF, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
Toll Like Receptor 4 (TLR4) Cascade (R-HSA-166016)	-	6.11	0.006	ERBB2, CASP8, EGFR, PPP2R1B, MAP3K8
MAPK1/MAPK3 signaling (R-HSA-5684996)	-	5.11	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Interleukin receptor SHC signaling (R-HSA-912526)	-	5.09	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Innate Immune System (R-HSA-168249)	-	3.17	0.001	KRAS, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
Signaling by SCF-KIT (R-HSA-1433557)	-	4.73	0.002	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, FASLG
Interleukin-2 signaling (R-HSA-451927)	-	5.05	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
SHC1 events in ERBB2 signaling (R-HSA-1250196)	-	5.15	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
NCAM signaling for neurite out-growth (R-HSA-375165)	-	4.9	0.018	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signalling to RAS (R-HSA-167044)	-	5.08	0.002	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)	-	7.05	0.04	ERBB2, EGFR, PIK3CA
DAP12 signaling (R-HSA-2424491)	-	4.64	0.015	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988)	-	4.99	0.002	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Downstream signaling of activated FGFR2 (R-HSA-5654696)	-	4.71	0.012	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Downstream signaling of activated FGFR4 (R-HSA-5654716)	-	4.71	0.012	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382)	-	8.73	0.001	KRAS, EGFR, PIK3CA
SHC1 events in EGFR signaling (R-HSA-180336)	-	5.15	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
NGF signalling via TRKA from the plasma membrane (R-HSA-187037)	-	4.51	0.004	KRAS, CASP8, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
FRS-mediated FGFR1 signaling (R-HSA-5654693)	-	5.14	0.008	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Prolonged ERK activation events (R-HSA-169893)	-	5.11	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Negative regulation of MAPK pathway (R-HSA-5675221)	-	7.66	0.039	BRAF, KRAS, PPP2R1B
Toll Like Receptor TLR1:TLR2 Cascade (R-HSA-168179)	-	6.51	0.001	PPP2R1B, ERBB2, CASP8, MAP3K8, EGFR
Signalling to ERKs (R-HSA-187687)	-	5.04	0.002	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by Leptin (R-HSA-2586552)	-	5.1	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by FGFR2 (R-HSA-5654738)	-	4.68	0.014	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
GRB2 events in EGFR signaling (R-HSA-179812)	-	5.15	0.008	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by FGFR1 (R-HSA-5654736)	-	4.69	0.014	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by EGFR (R-HSA-177929)	-	4.59	0.003	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
ARMS-mediated activation (R-HSA-170984)	-	5.12	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by FGFR4 in disease (R-HSA-5655291)	-	9.52	0.043	KRAS, PIK3CA
SOS-mediated signalling (R-HSA-112412)	-	5.15	0.001	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
SHC1 events in ERBB4 signaling (R-HSA-1250347)	-	5.15	0.008	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Signaling by ERBB2 (R-HSA-1227986)	-	4.66	0.015	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
IGF1R signaling cascade (R-HSA-2428924)	-	4.85	0.006	KRAS, BRAF, PIK3CA, ERBB2, PPP2R1B, EGFR, MAP3K8
Axon guidance (R-HSA-422475)	-	3.93	0.008	KRAS, MAP3K8, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
VEGFR2 mediated cell proliferation (R-HSA-5218921)	-	5.07	0.002	KRAS, BRAF, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA
Costimulation by the CD28 family (R-HSA-388841)	-	6.56	0.024	PPP2R1B, MAP3K8, FASLG, PIK3CA

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	15	SLC22A18, KRAS, ERCC6, CASP8, IRF1, PARK2, CYP2A6, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, MAP3K8, FASLG
protein binding (GO:0005515)	0.46	15	SLC22A18, KRAS, EGFR, CASP8, CYP2A6, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, ERCC6, MAP3K8, FASLG
catalytic activity (GO:0003824)	1.05	10	CYP2A6, ERCC6, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF
heterocyclic compound binding (GO:1901363)	1.06	10	CYP2A6, EGFR, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, ERCC6, MAP3K8
organic cyclic compound binding (GO:0097159)	1.05	10	CYP2A6, EGFR, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, ERCC6, MAP3K8
carbohydrate derivative binding (GO:0097367)	2.03	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
enzyme binding (GO:0019899)	2.27	7	CYP2A6, CASP8, BRAF, PARK2, SLC22A18, ERBB2, EGFR
nucleotide binding (GO:0000166)	1.96	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
small molecule binding (GO:0036094)	1.89	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
ribonucleotide binding (GO:0032553)	2.19	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
purine nucleoside binding (GO:0001883)	2.22	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
ribonucleoside binding (GO:0032549)	2.22	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
purine ribonucleotide binding (GO:0032555)	2.2	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
purine nucleotide binding (GO:0017076)	2.19	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
purine ribonucleoside binding (GO:0032550)	2.22	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
nucleoside phosphate binding (GO:1901265)	1.96	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
nucleoside binding (GO:0001882)	2.21	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
cation binding (GO:0043169)	1.4	6	CYP2A6, MAP3K8, PARK2, KRAS, RASSF1, BRAF
adenyl nucleotide binding (GO:0030554)	2.4	6	EGFR, MAP3K8, PIK3CA, ERBB2, ERCC6, BRAF
ion binding (GO:0043167)	1.36	6	CYP2A6, MAP3K8, PARK2, KRAS, RASSF1, BRAF
transferase activity (GO:0016740)	1.95	6	MAP3K8, PARK2, PIK3CA, ERBB2, EGFR, BRAF
adenyl ribonucleotide binding (GO:0032559)	2.41	6	EGFR, MAP3K8, PIK3CA, ERBB2, ERCC6, BRAF
identical protein binding (GO:0042802)	2.63	6	CASP8, BRAF, PARK2, RASSF1, ERBB2, EGFR
metal ion binding (GO:0046872)	1.41	6	CYP2A6, MAP3K8, PARK2, KRAS, RASSF1, BRAF
ATP binding (GO:0005524)	2.43	6	EGFR, MAP3K8, PIK3CA, ERBB2, ERCC6, BRAF
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	5	ERBB2, EGFR, MAP3K8, PIK3CA, BRAF
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	5	ERBB2, EGFR, MAP3K8, PIK3CA, BRAF
kinase activity (GO:0016301)	2.93	5	ERBB2, EGFR, MAP3K8, PIK3CA, BRAF
signal transducer activity (GO:0004871)	2.28	5	ERBB2, CASP8, MAP3K8, EGFR, BRAF
protein kinase activity (GO:0004672)	3.27	5	ERBB2, EGFR, MAP3K8, PIK3CA, BRAF
molecular function regulator (GO:0098772)	2.51	5	ERCC6, ERBB2, EGFR, PPP2R1B, PIK3CA
ubiquitin protein ligase binding (GO:0031625)	4.17	4	SLC22A18, PARK2, CASP8, EGFR
ubiquitin-like protein ligase binding (GO:0044389)	4.15	4	SLC22A18, PARK2, CASP8, EGFR
receptor signaling protein activity (GO:0005057)	4.76	4	ERBB2, MAP3K8, EGFR, BRAF
enzyme regulator activity (GO:0030234)	2.85	4	EGFR, ERCC6, PPP2R1B, PIK3CA
protein serine/threonine kinase activity (GO:0004674)	3.64	4	MAP3K8, EGFR, PIK3CA, BRAF
macromolecular complex binding (GO:0044877)	2.61	4	ERCC6, KRAS, CASP8, EGFR
nucleic acid binding (GO:0003676)	1.44	4	IRF1, PARK2, ERCC6, EGFR
DNA binding (GO:0003677)	1.92	4	IRF1, PARK2, ERCC6, EGFR
protein complex binding (GO:0032403)	3.09	4	ERCC6, KRAS, CASP8, EGFR
receptor binding (GO:0005102)	2.43	4	ERBB2, PARK2, CASP8, FASLG
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	5.61	3	ERBB2, EGFR, PIK3CA
hydrolase activity (GO:0016787)	1.9	3	KRAS, ERCC6, CASP8
transition metal ion binding (GO:0046914)	2.48	3	CYP2A6, PARK2, RASSF1
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	5.56	3	ERBB2, EGFR, PIK3CA
protein domain specific binding (GO:0019904)	3.32	3	PARK2, CASP8, KRAS
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	3	ERBB2, EGFR, PIK3CA
receptor signaling protein serine/threonine kinase activity (GO:0004702)	5.23	3	MAP3K8, BRAF, EGFR
protein dimerization activity (GO:0046983)	2.72	3	ERBB2, BRAF, EGFR
protein heterodimerization activity (GO:0046982)	3.64	3	ERBB2, BRAF, EGFR
MAP kinase kinase kinase activity (GO:0004709)	6.6	3	MAP3K8, BRAF, EGFR
double-stranded DNA binding (GO:0003690)	3.09	3	IRF1, PARK2, EGFR
cytokine receptor binding (GO:0005126)	4.14	2	CASP8, FASLG
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	ERBB2, EGFR
protein C-terminus binding (GO:0008022)	4.5	2	ERBB2, ERCC6
signaling receptor activity (GO:0038023)	2.49	2	ERBB2, EGFR
death receptor binding (GO:0005123)	6.91	2	CASP8, FASLG
kinase activator activity (GO:0019209)	5.58	2	ERCC6, PIK3CA
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	ERBB2, EGFR
tumor necrosis factor receptor binding (GO:0005164)	6.3	2	CASP8, FASLG
molecular transducer activity (GO:0060089)	2.32	2	ERBB2, EGFR
nucleic acid binding transcription factor activity (GO:0001071)	2.65	2	IRF1, PARK2
enzyme activator activity (GO:0008047)	3.56	2	ERCC6, PIK3CA
kinase regulator activity (GO:0019207)	4.5	2	ERCC6, PIK3CA
actin binding (GO:0003779)	3.74	2	PARK2, EGFR
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	IRF1, PARK2
sequence-specific DNA binding (GO:0043565)	2.79	2	IRF1, PARK2
receptor signaling protein tyrosine kinase activity (GO:0004716)	7.44	2	ERBB2, EGFR
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	5.55	2	ERBB2, EGFR
protein tyrosine kinase activity (GO:0004713)	4.54	2	ERBB2, EGFR
receptor activity (GO:0004872)	2.32	2	ERBB2, EGFR
tumor necrosis factor receptor superfamily binding (GO:0032813)	5.89	2	CASP8, FASLG
protein kinase regulator activity (GO:0019887)	4.6	2	ERCC6, PIK3CA
regulatory region nucleic acid binding (GO:0001067)	3.03	2	IRF1, PARK2
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	KRAS, ERCC6
protein kinase binding (GO:0019901)	3.44	2	BRAF, PARK2
kinase binding (GO:0019900)	3.32	2	BRAF, PARK2
protein phosphatase binding (GO:0019903)	4.93	2	ERBB2, EGFR
phosphatase binding (GO:0019902)	4.63	2	ERBB2, EGFR
protein kinase activator activity (GO:0030295)	5.68	2	ERCC6, PIK3CA
transcription regulatory region DNA binding (GO:0044212)	3.03	2	IRF1, PARK2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	KRAS, ERCC6
transmembrane receptor protein kinase activity (GO:0019199)	5.32	2	ERBB2, EGFR
protein N-terminus binding (GO:0047485)	5.11	2	ERCC6, RASSF1
cytoskeletal protein binding (GO:0008092)	3.02	2	PARK2, EGFR
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	2	IRF1, PARK2
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	KRAS, ERCC6
pyrophosphatase activity (GO:0016462)	3.04	2	KRAS, ERCC6
transmembrane signaling receptor activity (GO:0004888)	2.57	2	ERBB2, EGFR
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	IRF1, PARK2
regulatory region DNA binding (GO:0000975)	3.03	2	IRF1, PARK2
chromatin binding (GO:0003682)	3.64	2	ERCC6, EGFR
transmembrane receptor activity (GO:0099600)	2.53	2	ERBB2, EGFR
zinc ion binding (GO:0008270)	2.66	2	PARK2, RASSF1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine receptor binding (GO:0005126)	-	4.14	0.0	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, FASLG
cytokine activity (GO:0005125)	NEW	4.34	0.002	CASP8, IRF1, PIK3CA, ERBB2, EGFR, FASLG
small conjugating protein ligase binding (GO:0044389)	-	4.15	0.005	SLC22A18, CASP8, PARK2, EGFR, FASLG
kinase regulator activity (GO:0019207)	-	4.5	0.007	ERBB2, ERCC6, EGFR, FASLG, PIK3CA
kinase activator activity (GO:0019209)	-	5.58	0.002	ERBB2, ERCC6, EGFR, PIK3CA
carbohydrate binding (GO:0030246)	NEW	4.17	0.009	CASP8, IRF1, KRAS, ERBB2, EGFR, FASLG
enzyme binding (GO:0019899)	-	2.27	0.0	SLC22A18, KRAS, CASP8, CYP2A6, IRF1, PARK2, PPP2R1B, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
beta-tubulin binding (GO:0048487)	NEW	6.13	0.014	ERBB2, PARK2, EGFR
kinase binding (GO:0019900)	-	3.32	0.004	KRAS, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
enzyme activator activity (GO:0008047)	-	3.56	0.0	ERCC6, CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
purine nucleoside binding (GO:0001883)	-	2.22	0.001	KRAS, EGFR, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, ERCC6, MAP3K8, FASLG
guanyl ribonucleotide binding (GO:0032561)	NEW	3.73	0.006	KRAS, BRAF, PARK2, PIK3CA, ERBB2, RASSF1, EGFR
nucleoside phosphate binding (GO:1901265)	-	1.96	0.005	KRAS, EGFR, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, ERCC6, MAP3K8, FASLG
nucleoside binding (GO:0001882)	-	2.21	0.001	KRAS, EGFR, CASP8, IRF1, PARK2, PPP2R1B, BRAF, ERBB2, RASSF1, ERCC6, PIK3CA, MAP3K8, FASLG
anion binding (GO:0043168)	NEW	4.17	0.025	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, BRAF, ERBB2, RASSF1, EGFR, PIK3CA, IRF1, FASLG
transition metal ion binding (GO:0046914)	-	2.48	0.026	CYP2A6, ERCC6, CASP8, IRF1, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF
signaling adaptor activity (GO:0035591)	NEW	5.43	0.0	ERBB2, KRAS, PARK2, EGFR, FASLG
receptor signaling protein activity (GO:0005057)	-	4.76	0.0	IRF1, PIK3CA, BRAF, ERBB2, EGFR, MAP3K8, FASLG
receptor tyrosine kinase binding (GO:0030971)	NEW	5.77	0.041	ERBB2, KRAS, EGFR
peptidase regulator activity (GO:0061134)	NEW	4.37	0.049	ERBB2, CASP8, IRF1, EGFR, BRAF
nucleotide binding (GO:0000166)	-	1.96	0.005	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, MAP3K8, FASLG
receptor signaling protein tyrosine kinase activity (GO:0004716)	-	7.44	0.005	ERBB2, EGFR
protein serine/threonine kinase activity (GO:0004674)	-	3.64	0.001	MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
transferase activity (GO:0016740)	-	1.95	0.022	KRAS, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, IRF1, BRAF, FASLG
glutamate binding (GO:0016595)	NEW	7.54	0.03	ERBB2, EGFR
protein kinase activity (GO:0004672)	-	3.27	0.001	KRAS, MAP3K8, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
protein complex binding (GO:0032403)	-	3.09	0.0	KRAS, ERCC6, CASP8, IRF1, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
purine nucleotide binding (GO:0017076)	-	2.19	0.001	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, BRAF, ERBB2, RASSF1, EGFR, PIK3CA, IRF1, FASLG
carbohydrate derivative binding (GO:0097367)	-	2.03	0.005	KRAS, EGFR, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, ERCC6, MAP3K8, FASLG
ATP binding (GO:0005524)	-	2.43	0.0	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
GTP binding (GO:0005525)	NEW	3.78	0.004	KRAS, BRAF, PARK2, PIK3CA, ERBB2, RASSF1, EGFR
SH3/SH2 adaptor activity (GO:0005070)	NEW	5.79	0.001	ERBB2, KRAS, EGFR, FASLG
kinase activity (GO:0016301)	-	2.93	0.001	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
protein kinase regulator activity (GO:0019887)	-	4.6	0.003	FASLG, ERBB2, ERCC6, EGFR, PIK3CA
transporter activity (GO:0005215)	NEW	2.57	0.001	SLC22A18, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
ribonucleoside binding (GO:0032549)	-	2.22	0.001	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
GTPase activity (GO:0003924)	NEW	4.31	0.026	ERBB2, PARK2, EGFR, PIK3CA, BRAF
protein binding, bridging (GO:0030674)	NEW	4.68	0.006	FASLG, ERBB2, KRAS, EGFR, RASSF1
hydrolase activity, acting on ester bonds (GO:0016788)	NEW	3.1	0.034	CASP8, IRF1, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
nucleoside-triphosphatase activity (GO:0017111)	-	3.09	0.001	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
GTPase activator activity (GO:0005096)	NEW	4.11	0.049	PARK2, ERBB2, EGFR, KRAS, PIK3CA
GTPase regulator activity (GO:0030695)	NEW	4.01	0.012	CASP8, PARK2, KRAS, ERBB2, PIK3CA, EGFR
protein phosphatase binding (GO:0019903)	-	4.93	0.001	ERBB2, KRAS, EGFR, PPP2R1B, FASLG
phosphatase binding (GO:0019902)	-	4.63	0.0	KRAS, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, FASLG
nucleoside-triphosphatase regulator activity (GO:0060589)	NEW	3.92	0.021	CASP8, PARK2, KRAS, ERBB2, PIK3CA, EGFR
protein kinase activator activity (GO:0030295)	-	5.68	0.002	ERBB2, ERCC6, EGFR, PIK3CA
binding, bridging (GO:0060090)	NEW	4.57	0.0	KRAS, PARK2, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	-	3.03	0.003	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
ubiquitin protein ligase binding (GO:0031625)	-	4.17	0.005	SLC22A18, CASP8, PARK2, EGFR, FASLG
pyrophosphatase activity (GO:0016462)	-	3.04	0.003	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
adenyl nucleotide binding (GO:0030554)	-	2.4	0.0	KRAS, EGFR, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, ERCC6, MAP3K8, FASLG
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	-	3.08	0.0	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
transferase activity, transferring phosphorus-containing groups (GO:0016772)	-	2.77	0.0	KRAS, CASP8, IRF1, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, EGFR, MAP3K8, FASLG
protein tyrosine phosphatase activity (GO:0004725)	NEW	5.09	0.022	ERBB2, PARK2, FASLG, EGFR
hydrolase activity, acting on acid anhydrides (GO:0016817)	-	3.03	0.003	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
guanyl nucleotide binding (GO:0019001)	NEW	3.73	0.006	KRAS, BRAF, PARK2, PIK3CA, ERBB2, RASSF1, EGFR
purine ribonucleotide binding (GO:0032555)	-	2.2	0.001	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, IRF1, FASLG
receptor signaling protein serine/threonine kinase activity (GO:0004702)	-	5.23	0.004	MAP3K8, BRAF, EGFR
peptidase activator activity (GO:0016504)	NEW	6.13	0.03	BRAF, CASP8, EGFR
protein dimerization activity (GO:0046983)	-	2.72	0.003	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
protein heterodimerization activity (GO:0046982)	-	3.64	0.04	CASP8, IRF1, PARK2, KRAS, ERBB2, EGFR, BRAF
MAP kinase kinase kinase activity (GO:0004709)	-	6.6	0.0	MAP3K8, BRAF, EGFR
purine ribonucleoside binding (GO:0032550)	-	2.22	0.001	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, MAP3K8, FASLG
ribonucleotide binding (GO:0032553)	-	2.19	0.001	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism process (GO:0044699)	0.48	15	SLC22A18, KRAS, EGFR, CASP8, MAP3K8, PARK2, CYP2A6, RASSF1, BRAF, ERBB2, PPP2R1B, ERCC6, PIK3CA, IRF1, FASLG
cellular process (GO:0009987)	0.26	14	CYP2A6, KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, IRF1, FASLG
biological regulation (GO:0065007)	0.39	14	KRAS, DLEC1, EGFR, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, ERCC6, MAP3K8, FASLG
regulation of biological process (GO:0050789)	0.45	14	KRAS, DLEC1, EGFR, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, ERCC6, MAP3K8, FASLG
regulation of cellular process (GO:0050794)	0.5	14	KRAS, EGFR, CASP8, MAP3K8, PARK2, DLEC1, PPP2R1B, BRAF, ERBB2, RASSF1, ERCC6, PIK3CA, IRF1, FASLG
regulation of primary metabolic process (GO:0080090)	1.08	13	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, IRF1, BRAF, FASLG
regulation of metabolic process (GO:0019222)	1.02	13	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, IRF1, BRAF, FASLG
regulation of macromolecule metabolic process (GO:0060255)	1.08	13	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, IRF1, FASLG
regulation of cellular metabolic process (GO:0031323)	1.07	13	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
regulation of protein metabolic process (GO:0051246)	1.93	13	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
single-organism cellular process (GO:0044763)	0.65	13	CYP2A6, KRAS, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
positive regulation of biological process (GO:0048518)	1.2	13	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, IRF1, BRAF, FASLG
positive regulation of cellular process (GO:0048522)	1.3	13	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, EGFR, MAP3K8, FASLG
primary metabolic process (GO:0044238)	0.69	12	CYP2A6, EGFR, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, ERCC6, MAP3K8, FASLG
regulation of cellular protein metabolic process (GO:0032268)	1.99	12	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
positive regulation of metabolic process (GO:0009893)	1.74	12	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
regulation of signal transduction (GO:0009966)	1.84	12	KRAS, ERCC6, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
response to stimulus (GO:0050896)	1.22	12	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
regulation of response to stimulus (GO:0048583)	1.54	12	KRAS, ERCC6, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
positive regulation of protein metabolic process (GO:0051247)	2.43	12	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
organic substance metabolic process (GO:0071704)	0.63	12	CYP2A6, ERCC6, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
metabolic process (GO:0008152)	0.58	12	CYP2A6, EGFR, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, ERCC6, MAP3K8, FASLG
regulation of signaling (GO:0023051)	1.72	12	KRAS, EGFR, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, ERCC6, IRF1, BRAF, FASLG
regulation of cell communication (GO:0010646)	1.73	12	KRAS, ERCC6, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
positive regulation of cellular metabolic process (GO:0031325)	1.81	12	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	12	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
regulation of catalytic activity (GO:0050790)	1.97	11	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
positive regulation of response to stimulus (GO:0048584)	2.18	11	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
cellular metabolic process (GO:0044237)	0.69	11	CYP2A6, EGFR, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, ERCC6, MAP3K8, FASLG
macromolecule metabolic process (GO:0043170)	0.83	11	ERCC6, CASP8, MAP3K8, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, IRF1, FASLG
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	11	KRAS, EGFR, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF, FASLG
signal transduction (GO:0007165)	1.28	11	KRAS, ERCC6, CASP8, IRF1, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
negative regulation of biological process (GO:0048519)	1.33	11	KRAS, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, DLEC1, FASLG
regulation of molecular function (GO:0065009)	1.78	11	KRAS, EGFR, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, ERCC6, BRAF, FASLG
negative regulation of cellular process (GO:0048523)	1.41	11	KRAS, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, DLEC1, FASLG
cellular response to stimulus (GO:0051716)	1.97	10	ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1
cellular macromolecule metabolic process (GO:0044260)	0.93	10	EGFR, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, ERCC6, MAP3K8, FASLG
positive regulation of signal transduction (GO:0009967)	2.5	10	ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, KRAS, EGFR, BRAF, FASLG
positive regulation of signaling (GO:0023056)	2.41	10	ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, KRAS, EGFR, BRAF, FASLG
positive regulation of molecular function (GO:0044093)	2.23	10	ERCC6, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
regulation of protein modification process (GO:0031399)	2.32	10	KRAS, ERCC6, MAP3K8, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF
response to chemical (GO:0042221)	1.98	10	ERCC6, CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
positive regulation of cell communication (GO:0010647)	2.41	10	EGFR, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, KRAS, ERCC6, BRAF, FASLG
regulation of intracellular signal transduction (GO:1902531)	2.31	10	EGFR, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF, FASLG
regulation of phosphate metabolic process (GO:0019220)	2.35	9	KRAS, EGFR, MAP3K8, PARK2, PIK3CA, ERBB2, PPP2R1B, ERCC6, BRAF
positive regulation of protein modification process (GO:0031401)	2.7	9	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of gene expression (GO:0010468)	1.37	9	EGFR, IRF1, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF, FASLG
regulation of phosphorus metabolic process (GO:0051174)	2.35	9	KRAS, EGFR, MAP3K8, PARK2, PIK3CA, ERBB2, PPP2R1B, ERCC6, BRAF
positive regulation of intracellular signal transduction (GO:1902533)	2.95	9	EGFR, CASP8, MAP3K8, PARK2, KRAS, ERBB2, ERCC6, BRAF, FASLG
intracellular signal transduction (GO:0035556)	2.39	9	KRAS, EGFR, CASP8, MAP3K8, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
response to organic substance (GO:0010033)	2.2	9	CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
positive regulation of catalytic activity (GO:0043085)	2.4	9	EGFR, CASP8, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF, FASLG
regulation of phosphorylation (GO:0042325)	2.5	8	EGFR, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
developmental process (GO:0032502)	1.36	8	EGFR, CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, ERCC6
single-organism metabolic process (GO:0044710)	1.63	8	CYP2A6, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF
multicellular organismal process (GO:0032501)	1.45	8	SLC22A18, EGFR, IRF1, PARK2, PIK3CA, KRAS, ERCC6, BRAF
protein metabolic process (GO:0019538)	1.45	8	CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF
regulation of kinase activity (GO:0043549)	3.07	8	EGFR, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
regulation of cell death (GO:0010941)	2.43	8	KRAS, CASP8, BRAF, PARK2, PIK3CA, PPP2R1B, EGFR, FASLG
response to stress (GO:0006950)	1.8	8	EGFR, CASP8, IRF1, PARK2, RASSF1, ERBB2, ERCC6, MAP3K8
regulation of transferase activity (GO:0051338)	2.88	8	EGFR, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
regulation of protein phosphorylation (GO:0001932)	2.57	8	EGFR, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	8	EGFR, IRF1, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, FASLG
regulation of programmed cell death (GO:0043067)	2.49	8	KRAS, CASP8, BRAF, PARK2, PIK3CA, PPP2R1B, EGFR, FASLG
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	8	EGFR, IRF1, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, FASLG
regulation of biological quality (GO:0065008)	1.68	8	KRAS, CASP8, IRF1, PARK2, PIK3CA, RASSF1, BRAF, FASLG
regulation of apoptotic process (GO:0042981)	2.5	8	KRAS, CASP8, BRAF, PARK2, PIK3CA, PPP2R1B, EGFR, FASLG
cellular component organization or biogenesis (GO:0071840)	1.22	8	KRAS, CASP8, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR
cellular component organization (GO:0016043)	1.24	8	KRAS, CASP8, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR
cellular response to chemical stimulus (GO:0070887)	2.57	7	CASP8, IRF1, PARK2, PIK3CA, ERBB2, EGFR, BRAF
positive regulation of kinase activity (GO:0033674)	3.54	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
regulation of cellular biosynthetic process (GO:0031326)	1.38	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
positive regulation of gene expression (GO:0010628)	2.35	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, BRAF
cell surface receptor signaling pathway (GO:0007166)	2.09	7	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, FASLG
regulation of MAPK cascade (GO:0043408)	3.22	7	EGFR, MAP3K8, PARK2, KRAS, ERBB2, ERCC6, BRAF
cellular protein metabolic process (GO:0044267)	1.63	7	MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF
positive regulation of transferase activity (GO:0051347)	3.31	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
cellular developmental process (GO:0048869)	1.82	7	CASP8, IRF1, KRAS, ERBB2, EGFR, BRAF, FASLG
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
negative regulation of apoptotic process (GO:0043066)	3.04	7	CASP8, BRAF, PARK2, PIK3CA, KRAS, EGFR, FASLG
negative regulation of programmed cell death (GO:0043069)	3.02	7	CASP8, BRAF, PARK2, PIK3CA, KRAS, EGFR, FASLG
regulation of cell proliferation (GO:0042127)	2.41	7	DLEC1, KRAS, BRAF, ERBB2, EGFR, IRF1, FASLG
positive regulation of phosphate metabolic process (GO:0045937)	2.78	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
regulation of developmental process (GO:0050793)	2.1	7	CASP8, IRF1, PARK2, PIK3CA, ERBB2, BRAF, FASLG
negative regulation of cell death (GO:0060548)	2.95	7	CASP8, BRAF, PARK2, PIK3CA, KRAS, EGFR, FASLG
regulation of protein kinase activity (GO:0045859)	3.15	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
regulation of biosynthetic process (GO:0009889)	1.37	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
cellular protein modification process (GO:0006464)	1.79	7	MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF
single-organism developmental process (GO:0044767)	1.49	7	ERCC6, CASP8, BRAF, PIK3CA, ERBB2, KRAS, EGFR
macromolecule modification (GO:0043412)	1.73	7	MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF
protein modification process (GO:0036211)	1.79	7	MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
regulation of multicellular organismal process (GO:0051239)	1.87	7	CASP8, IRF1, PARK2, PIK3CA, ERBB2, BRAF, FASLG
regulation of RNA biosynthetic process (GO:2001141)	1.55	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
response to oxygen-containing compound (GO:1901700)	2.57	7	EGFR, CASP8, BRAF, PARK2, PIK3CA, ERCC6, FASLG
positive regulation of phosphorylation (GO:0042327)	2.9	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
single-multicellular organism process (GO:0044707)	1.78	7	EGFR, IRF1, PARK2, PIK3CA, KRAS, ERCC6, BRAF
regulation of response to stress (GO:0080134)	2.53	7	ERCC6, CASP8, IRF1, PARK2, KRAS, EGFR, BRAF
regulation of RNA metabolic process (GO:0051252)	1.52	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
immune system process (GO:0002376)	2.29	7	CASP8, MAP3K8, PIK3CA, BRAF, KRAS, IRF1, FASLG
regulation of transcription, DNA-templated (GO:0006355)	1.56	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	7	EGFR, IRF1, PARK2, KRAS, ERBB2, ERCC6, FASLG
positive regulation of protein kinase activity (GO:0045860)	3.61	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
positive regulation of protein phosphorylation (GO:0001934)	2.95	7	EGFR, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
response to abiotic stimulus (GO:0009628)	2.8	6	EGFR, CASP8, IRF1, KRAS, ERCC6, BRAF
protein phosphorylation (GO:0006468)	2.89	6	MAP3K8, KRAS, ERBB2, PIK3CA, EGFR, BRAF
biosynthetic process (GO:0009058)	1.32	6	IRF1, PARK2, PIK3CA, ERBB2, ERCC6, FASLG
organic substance biosynthetic process (GO:1901576)	1.34	6	IRF1, PARK2, PIK3CA, ERBB2, ERCC6, FASLG
phosphorylation (GO:0016310)	2.63	6	MAP3K8, KRAS, ERBB2, PIK3CA, EGFR, BRAF
system process (GO:0003008)	2.3	6	SLC22A18, BRAF, PARK2, KRAS, PIK3CA, EGFR
anatomical structure development (GO:0048856)	1.58	6	BRAF, PARK2, KRAS, ERBB2, PIK3CA, EGFR
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	CYP2A6, IRF1, PARK2, ERBB2, ERCC6, FASLG
phosphate-containing compound metabolic process (GO:0006796)	2.16	6	MAP3K8, KRAS, ERBB2, PIK3CA, EGFR, BRAF
cellular response to organic substance (GO:0071310)	2.78	6	CASP8, IRF1, PARK2, PIK3CA, ERBB2, EGFR
positive regulation of MAPK cascade (GO:0043410)	3.57	6	EGFR, MAP3K8, KRAS, ERBB2, ERCC6, BRAF
cellular biosynthetic process (GO:0044249)	1.37	6	IRF1, PARK2, PIK3CA, ERBB2, ERCC6, FASLG
regulation of MAP kinase activity (GO:0043405)	3.95	6	EGFR, MAP3K8, KRAS, ERBB2, ERCC6, BRAF
regulation of immune system process (GO:0002682)	2.5	6	CASP8, IRF1, KRAS, ERBB2, PIK3CA, MAP3K8
phosphorus metabolic process (GO:0006793)	2.15	6	MAP3K8, KRAS, ERBB2, PIK3CA, EGFR, BRAF
regulation of multicellular organismal development (GO:2000026)	2.31	6	CASP8, IRF1, PARK2, ERBB2, BRAF, FASLG
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	6	EGFR, MAP3K8, KRAS, ERBB2, ERCC6, BRAF
regulation of cell differentiation (GO:0045595)	2.42	6	CASP8, IRF1, PARK2, KRAS, ERBB2, BRAF
organic cyclic compound metabolic process (GO:1901360)	1.26	6	CYP2A6, IRF1, PARK2, ERBB2, ERCC6, FASLG
heterocycle metabolic process (GO:0046483)	1.31	6	CYP2A6, IRF1, PARK2, ERBB2, ERCC6, FASLG
negative regulation of metabolic process (GO:0009892)	1.93	5	IRF1, CASP8, PARK2, EGFR, FASLG
RNA biosynthetic process (GO:0032774)	1.84	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
regulation of cellular localization (GO:0060341)	3.03	5	ERBB2, CASP8, PARK2, BRAF, EGFR
positive regulation of biosynthetic process (GO:0009891)	2.29	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
regulation of transport (GO:0051049)	2.24	5	ERBB2, CASP8, PARK2, BRAF, EGFR
regulation of cell adhesion (GO:0030155)	3.27	5	ERBB2, BRAF, IRF1, PIK3CA, MAP3K8
cell differentiation (GO:0030154)	2.14	5	ERBB2, KRAS, IRF1, CASP8, BRAF
activation of protein kinase activity (GO:0032147)	4.08	5	MAP3K8, ERCC6, EGFR, PIK3CA, BRAF
regulation of cellular component organization (GO:0051128)	2.01	5	ERBB2, CASP8, PARK2, BRAF, EGFR
nucleic acid metabolic process (GO:0090304)	1.46	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
negative regulation of signaling (GO:0023057)	2.65	5	BRAF, CASP8, PARK2, EGFR, FASLG
cellular nitrogen compound metabolic process (GO:0034641)	1.22	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
regulation of neuron apoptotic process (GO:0043523)	4.47	5	BRAF, KRAS, PARK2, FASLG, PIK3CA
negative regulation of cell communication (GO:0010648)	2.66	5	BRAF, CASP8, PARK2, FASLG, EGFR
cellular macromolecule biosynthetic process (GO:0034645)	1.66	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
cell death (GO:0008219)	3.05	5	IRF1, CASP8, FASLG, PPP2R1B, MAP3K8
organic cyclic compound biosynthetic process (GO:1901362)	1.66	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
nucleic acid-templated transcription (GO:0097659)	1.91	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
nucleobase-containing compound metabolic process (GO:0006139)	1.35	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
establishment of localization (GO:0051234)	1.48	5	PARK2, BRAF, SLC22A18, EGFR, PIK3CA
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	5	IRF1, CASP8, PARK2, EGFR, FASLG
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
MAPK cascade (GO:0000165)	3.91	5	ERBB2, KRAS, MAP3K8, EGFR, BRAF
response to organic cyclic compound (GO:0014070)	3.07	5	BRAF, CASP8, PARK2, EGFR, KRAS
signal transduction by protein phosphorylation (GO:0023014)	3.79	5	ERBB2, KRAS, MAP3K8, EGFR, BRAF
heterocycle biosynthetic process (GO:0018130)	1.7	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
regulation of hydrolase activity (GO:0051336)	2.53	5	FASLG, ERBB2, CASP8, PPP2R1B, EGFR
apoptotic process (GO:0006915)	3.14	5	PPP2R1B, IRF1, FASLG, CASP8, MAP3K8
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
transport (GO:0006810)	1.51	5	PARK2, BRAF, SLC22A18, EGFR, PIK3CA
programmed cell death (GO:0012501)	3.1	5	PPP2R1B, IRF1, CASP8, MAP3K8, FASLG
macromolecule biosynthetic process (GO:0009059)	1.61	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
regulation of neuron death (GO:1901214)	4.19	5	FASLG, PARK2, KRAS, PIK3CA, BRAF
regulation of localization (GO:0032879)	1.94	5	ERBB2, CASP8, PARK2, BRAF, EGFR
localization (GO:0051179)	1.4	5	PARK2, BRAF, SLC22A18, EGFR, PIK3CA
RNA metabolic process (GO:0016070)	1.59	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
positive regulation of RNA metabolic process (GO:0051254)	2.51	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	5	PARK2, ERBB2, ERCC6, IRF1, EGFR
nitrogen compound metabolic process (GO:0006807)	1.13	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
transcription, DNA-templated (GO:0006351)	1.91	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
aromatic compound biosynthetic process (GO:0019438)	1.7	5	PARK2, ERBB2, ERCC6, IRF1, FASLG
positive regulation of apoptotic signaling pathway (GO:2001235)	4.58	4	CASP8, PARK2, FASLG, PPP2R1B
cellular component assembly (GO:0022607)	2.14	4	BRAF, PARK2, CASP8, PPP2R1B
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	4	ERBB2, KRAS, EGFR, PIK3CA
regulation of apoptotic signaling pathway (GO:2001233)	3.83	4	CASP8, PARK2, FASLG, PPP2R1B
regulation of cell activation (GO:0050865)	3.53	4	IRF1, ERBB2, MAP3K8, PIK3CA
response to radiation (GO:0009314)	3.69	4	BRAF, KRAS, ERCC6, EGFR
negative regulation of response to stimulus (GO:0048585)	2.52	4	CASP8, PARK2, EGFR, FASLG
negative regulation of cellular metabolic process (GO:0031324)	2.01	4	IRF1, PARK2, CASP8, FASLG
behavior (GO:0007610)	3.47	4	BRAF, PARK2, KRAS, EGFR
learning or memory (GO:0007611)	4.33	4	BRAF, PARK2, KRAS, EGFR
homeostatic process (GO:0042592)	2.61	4	FASLG, PARK2, KRAS, PIK3CA
regulation of cell-cell adhesion (GO:0022407)	3.79	4	IRF1, ERBB2, MAP3K8, PIK3CA
response to light stimulus (GO:0009416)	4.08	4	BRAF, KRAS, ERCC6, EGFR
ERBB signaling pathway (GO:0038127)	5.36	4	ERBB2, KRAS, EGFR, PIK3CA
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	4	ERBB2, KRAS, EGFR, PIK3CA
positive regulation of cell death (GO:0010942)	3.32	4	CASP8, PARK2, FASLG, PPP2R1B
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	4	ERBB2, KRAS, ERCC6, EGFR
ERBB2 signaling pathway (GO:0038128)	6.09	4	ERBB2, KRAS, EGFR, PIK3CA
regulation of protein localization (GO:0032880)	2.88	4	ERBB2, PARK2, CASP8, EGFR
response to endogenous stimulus (GO:0009719)	2.79	4	BRAF, PARK2, EGFR, KRAS
macromolecular complex assembly (GO:0065003)	2.55	4	BRAF, PARK2, CASP8, PPP2R1B
negative regulation of neuron death (GO:1901215)	4.57	4	BRAF, PARK2, KRAS, PIK3CA
positive regulation of hydrolase activity (GO:0051345)	2.91	4	ERBB2, CASP8, FASLG, EGFR
positive regulation of cell adhesion (GO:0045785)	3.79	4	ERBB2, MAP3K8, PIK3CA, BRAF
response to lipid (GO:0033993)	3.11	4	KRAS, CASP8, FASLG, EGFR
positive regulation of multicellular organismal process (GO:0051240)	2.49	4	IRF1, PARK2, BRAF, CASP8
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	4	ERBB2, PARK2, BRAF, FASLG
movement of cell or subcellular component (GO:0006928)	2.61	4	ERBB2, KRAS, EGFR, PIK3CA
positive regulation of apoptotic process (GO:0043065)	3.38	4	CASP8, PARK2, FASLG, PPP2R1B
macromolecular complex subunit organization (GO:0043933)	2.14	4	BRAF, PARK2, CASP8, PPP2R1B
positive regulation of immune system process (GO:0002684)	2.96	4	MAP3K8, KRAS, CASP8, PIK3CA
animal organ development (GO:0048513)	2.53	4	ERBB2, EGFR, PIK3CA, BRAF
biological adhesion (GO:0022610)	2.81	4	IRF1, CASP8, BRAF, EGFR
positive regulation of programmed cell death (GO:0043068)	3.38	4	CASP8, PARK2, FASLG, PPP2R1B
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	4	ERBB2, IRF1, PIK3CA, MAP3K8
positive regulation of cell proliferation (GO:0008284)	3.01	4	ERBB2, KRAS, FASLG, EGFR
negative regulation of developmental process (GO:0051093)	3.17	4	ERBB2, PARK2, IRF1, FASLG
regulation of establishment of protein localization (GO:0070201)	3.02	4	ERBB2, PARK2, CASP8, EGFR
single organism cell adhesion (GO:0098602)	3.63	4	IRF1, CASP8, BRAF, EGFR
lipid metabolic process (GO:0006629)	2.68	4	CYP2A6, ERBB2, EGFR, PIK3CA
activation of MAPKK activity (GO:0000186)	5.74	4	MAP3K8, ERCC6, BRAF, EGFR
positive regulation of transport (GO:0051050)	2.9	4	ERBB2, PARK2, CASP8, EGFR
cell-cell adhesion (GO:0098609)	3.34	4	IRF1, CASP8, BRAF, EGFR
neurological system process (GO:0050877)	2.64	4	BRAF, PARK2, KRAS, EGFR
protein complex assembly (GO:0006461)	2.78	4	BRAF, PARK2, CASP8, PPP2R1B
single organismal cell-cell adhesion (GO:0016337)	3.69	4	IRF1, CASP8, BRAF, EGFR
cell activation (GO:0001775)	3.47	4	IRF1, CASP8, BRAF, PIK3CA
regulation of lymphocyte activation (GO:0051249)	3.73	4	ERBB2, IRF1, PIK3CA, MAP3K8
regulation of T cell activation (GO:0050863)	4.05	4	ERBB2, IRF1, PIK3CA, MAP3K8
cell adhesion (GO:0007155)	2.82	4	IRF1, CASP8, BRAF, EGFR
cellular lipid metabolic process (GO:0044255)	2.92	4	CYP2A6, ERBB2, EGFR, PIK3CA
response to inorganic substance (GO:0010035)	3.56	4	BRAF, PARK2, ERCC6, CASP8
single-organism localization (GO:1902578)	2.09	4	BRAF, PARK2, SLC22A18, PIK3CA
multi-organism process (GO:0051704)	2.65	4	IRF1, PARK2, CASP8, KRAS
organelle organization (GO:0006996)	2.02	4	CASP8, PARK2, KRAS, PIK3CA
regulation of cellular protein localization (GO:1903827)	3.43	4	ERBB2, PARK2, CASP8, EGFR
regulation of immune response (GO:0050776)	2.98	4	IRF1, KRAS, CASP8, PIK3CA
negative regulation of signal transduction (GO:0009968)	2.75	4	CASP8, PARK2, EGFR, FASLG
response to external stimulus (GO:0009605)	2.55	4	IRF1, PARK2, CASP8, FASLG
positive regulation of MAP kinase activity (GO:0043406)	4.39	4	ERBB2, KRAS, ERCC6, EGFR
single-organism behavior (GO:0044708)	3.79	4	BRAF, PARK2, EGFR, KRAS
regulation of cellular response to stress (GO:0080135)	3.4	4	BRAF, PARK2, ERCC6, EGFR
cognition (GO:0050890)	4.2	4	BRAF, PARK2, KRAS, EGFR
single-organism transport (GO:0044765)	2.18	4	BRAF, PARK2, SLC22A18, PIK3CA
regulation of leukocyte activation (GO:0002694)	3.6	4	ERBB2, IRF1, PIK3CA, MAP3K8
single-organism organelle organization (GO:1902589)	2.68	4	KRAS, PARK2, CASP8, PIK3CA
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	4	IRF1, PARK2, FASLG, EGFR
cellular response to stress (GO:0033554)	2.51	4	MAP3K8, PARK2, ERCC6, RASSF1
protein complex subunit organization (GO:0071822)	2.6	4	BRAF, PARK2, CASP8, PPP2R1B
negative regulation of neuron apoptotic process (GO:0043524)	4.82	4	BRAF, PARK2, KRAS, PIK3CA
positive regulation of cellular component organization (GO:0051130)	2.68	4	ERBB2, PARK2, BRAF, CASP8
regulation of growth (GO:0040008)	3.26	4	ERBB2, PARK2, EGFR, PIK3CA
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	3	PARK2, CASP8, FASLG
regulation of intracellular protein transport (GO:0033157)	3.8	3	ERBB2, PARK2, EGFR
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	3	CASP8, FASLG, PPP2R1B
regulation of intracellular transport (GO:0032386)	3.58	3	ERBB2, PARK2, EGFR
learning (GO:0007612)	4.85	3	BRAF, PARK2, KRAS
mitochondrion organization (GO:0007005)	3.69	3	PARK2, CASP8, PIK3CA
response to external biotic stimulus (GO:0043207)	3.13	3	IRF1, CASP8, FASLG
response to growth factor (GO:0070848)	4.14	3	ERBB2, FASLG, EGFR
interspecies interaction between organisms (GO:0044419)	3.08	3	IRF1, PARK2, CASP8
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	3	PARK2, CASP8, FASLG
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	4.54	3	PARK2, CASP8, FASLG
cellular homeostasis (GO:0019725)	3.23	3	PARK2, FASLG, PIK3CA
lymphocyte activation (GO:0046649)	3.96	3	IRF1, BRAF, CASP8
epidermal growth factor receptor signaling pathway (GO:0007173)	5.72	3	KRAS, EGFR, PIK3CA
response to metal ion (GO:0010038)	3.91	3	BRAF, PARK2, CASP8
glycerolipid metabolic process (GO:0046486)	3.91	3	ERBB2, EGFR, PIK3CA
regulation of hemopoiesis (GO:1903706)	4.0	3	ERBB2, IRF1, CASP8
single organism signaling (GO:0044700)	3.25	3	PARK2, KRAS, FASLG
cell migration (GO:0016477)	3.12	3	KRAS, EGFR, PIK3CA
response to biotic stimulus (GO:0009607)	3.09	3	IRF1, CASP8, FASLG
cell motility (GO:0048870)	3.02	3	KRAS, EGFR, PIK3CA
response to organonitrogen compound (GO:0010243)	3.2	3	BRAF, PARK2, EGFR
positive regulation of organelle organization (GO:0010638)	3.38	3	BRAF, PARK2, CASP8
chemical homeostasis (GO:0048878)	2.97	3	PARK2, FASLG, PIK3CA
organophosphate metabolic process (GO:0019637)	3.04	3	ERBB2, EGFR, PIK3CA
negative regulation of biosynthetic process (GO:0009890)	2.47	3	IRF1, PARK2, FASLG
leukocyte activation (GO:0045321)	3.76	3	IRF1, BRAF, CASP8
negative regulation of gene expression (GO:0010629)	2.48	3	IRF1, PARK2, FASLG
regulation of protein transport (GO:0051223)	3.12	3	ERBB2, PARK2, EGFR
regulation of innate immune response (GO:0045088)	3.86	3	IRF1, KRAS, CASP8
regulation of oxidoreductase activity (GO:0051341)	5.27	3	PARK2, EGFR, KRAS
positive regulation of establishment of protein localization (GO:1904951)	3.49	3	ERBB2, CASP8, EGFR
immune response-regulating signaling pathway (GO:0002764)	3.72	3	KRAS, CASP8, PIK3CA
regulation of defense response (GO:0031347)	3.11	3	IRF1, KRAS, CASP8
phosphatidylinositol phosphorylation (GO:0046854)	5.19	3	ERBB2, EGFR, PIK3CA
lymphocyte aggregation (GO:0071593)	4.44	3	IRF1, BRAF, CASP8
positive regulation of proteolysis (GO:0045862)	3.86	3	PARK2, CASP8, FASLG
phosphatidylinositol-mediated signaling (GO:0048015)	4.93	3	ERBB2, EGFR, PIK3CA
leukocyte differentiation (GO:0002521)	4.13	3	IRF1, BRAF, CASP8
immune response-activating signal transduction (GO:0002757)	3.8	3	KRAS, CASP8, PIK3CA
response to nitrogen compound (GO:1901698)	3.12	3	BRAF, PARK2, EGFR
regulation of protein stability (GO:0031647)	4.33	3	PARK2, KRAS, RASSF1
regulation of cell motility (GO:2000145)	3.16	3	ERBB2, BRAF, EGFR
T cell aggregation (GO:0070489)	4.45	3	IRF1, BRAF, CASP8
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	IRF1, PARK2, FASLG
regulation of organelle organization (GO:0033043)	2.72	3	BRAF, PARK2, CASP8
positive regulation of cell growth (GO:0030307)	4.73	3	ERBB2, PARK2, EGFR
modulation of synaptic transmission (GO:0050804)	4.09	3	BRAF, PARK2, KRAS
signaling (GO:0023052)	3.25	3	PARK2, FASLG, KRAS
regulation of protein targeting (GO:1903533)	4.0	3	ERBB2, PARK2, EGFR
anatomical structure morphogenesis (GO:0009653)	2.53	3	BRAF, KRAS, EGFR
positive regulation of cellular protein localization (GO:1903829)	3.85	3	ERBB2, CASP8, EGFR
glycerophospholipid metabolic process (GO:0006650)	4.13	3	ERBB2, EGFR, PIK3CA
negative regulation of protein metabolic process (GO:0051248)	2.82	3	PARK2, CASP8, EGFR
negative regulation of multicellular organismal process (GO:0051241)	2.84	3	ERBB2, IRF1, FASLG
lipid phosphorylation (GO:0046834)	5.13	3	ERBB2, EGFR, PIK3CA
inositol lipid-mediated signaling (GO:0048017)	4.91	3	ERBB2, EGFR, PIK3CA
negative regulation of cell proliferation (GO:0008285)	3.26	3	IRF1, DLEC1, ERBB2
phospholipid metabolic process (GO:0006644)	3.88	3	ERBB2, EGFR, PIK3CA
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	3	IRF1, PARK2, FASLG
positive regulation of cell differentiation (GO:0045597)	3.01	3	BRAF, PARK2, CASP8
negative regulation of cell differentiation (GO:0045596)	3.33	3	ERBB2, IRF1, KRAS
regulation of cell growth (GO:0001558)	3.75	3	ERBB2, PARK2, EGFR
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	3	IRF1, PARK2, FASLG
viral process (GO:0016032)	3.15	3	IRF1, PARK2, CASP8
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	3	ERBB2, EGFR, PIK3CA
lipid modification (GO:0030258)	4.37	3	ERBB2, EGFR, PIK3CA
phosphatidylinositol metabolic process (GO:0046488)	4.46	3	ERBB2, EGFR, PIK3CA
positive regulation of developmental process (GO:0051094)	2.77	3	BRAF, PARK2, CASP8
cellular response to organic cyclic compound (GO:0071407)	3.93	3	PARK2, CASP8, EGFR
negative regulation of RNA metabolic process (GO:0051253)	2.66	3	IRF1, PARK2, FASLG
positive regulation of immune response (GO:0050778)	3.4	3	KRAS, CASP8, PIK3CA
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	3	IRF1, PARK2, EGFR
system development (GO:0048731)	2.92	3	ERBB2, PARK2, PIK3CA
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	3	ERBB2, BRAF, EGFR
positive regulation of growth (GO:0045927)	4.25	3	ERBB2, PARK2, EGFR
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	IRF1, PARK2, FASLG
apoptotic signaling pathway (GO:0097190)	4.12	3	CASP8, ERCC6, FASLG
T cell activation (GO:0042110)	4.45	3	IRF1, BRAF, CASP8
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	3	IRF1, PARK2, FASLG
regulation of locomotion (GO:0040012)	3.12	3	ERBB2, BRAF, EGFR
organic substance transport (GO:0071702)	2.15	3	BRAF, PARK2, SLC22A18
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	IRF1, PARK2, FASLG
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	3	IRF1, PARK2, FASLG
multi-organism cellular process (GO:0044764)	3.14	3	IRF1, PARK2, CASP8
cellular component disassembly (GO:0022411)	3.52	3	PARK2, CASP8, PIK3CA
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	IRF1, PARK2, FASLG
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	3	IRF1, PARK2, CASP8
cell-cell signaling (GO:0007267)	3.35	3	PARK2, KRAS, FASLG
cell communication (GO:0007154)	3.04	3	PARK2, KRAS, FASLG
leukocyte aggregation (GO:0070486)	4.41	3	IRF1, BRAF, CASP8
leukocyte cell-cell adhesion (GO:0007159)	4.26	3	IRF1, BRAF, CASP8
locomotion (GO:0040011)	2.91	3	KRAS, EGFR, PIK3CA
cellular response to oxygen-containing compound (GO:1901701)	3.22	3	PARK2, EGFR, PIK3CA
regulation of cellular component movement (GO:0051270)	3.08	3	ERBB2, BRAF, EGFR
regulation of cell cycle (GO:0051726)	2.93	3	IRF1, EGFR, RASSF1
regulation of leukocyte differentiation (GO:1902105)	4.26	3	ERBB2, IRF1, CASP8
activation of immune response (GO:0002253)	3.67	3	KRAS, CASP8, PIK3CA
regulation of proteolysis (GO:0030162)	3.2	3	PARK2, CASP8, FASLG
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	5.13	2	CASP8, FASLG
positive regulation of intracellular transport (GO:0032388)	4.08	2	ERBB2, EGFR
cytokine-mediated signaling pathway (GO:0019221)	3.6	2	IRF1, KRAS
regulation of secretion (GO:0051046)	3.2	2	BRAF, PARK2
anatomical structure homeostasis (GO:0060249)	4.25	2	PARK2, KRAS
negative regulation of secretion (GO:0051048)	4.44	2	BRAF, PARK2
positive regulation of neuron apoptotic process (GO:0043525)	5.88	2	PARK2, FASLG
alpha-beta T cell differentiation (GO:0046632)	6.15	2	IRF1, BRAF
alpha-beta T cell activation (GO:0046631)	5.92	2	IRF1, BRAF
mitophagy in response to mitochondrial depolarization (GO:0098779)	4.85	2	PARK2, PIK3CA
negative regulation of cell adhesion (GO:0007162)	4.33	2	ERBB2, IRF1
small molecule metabolic process (GO:0044281)	2.38	2	CYP2A6, PIK3CA
inorganic ion homeostasis (GO:0098771)	3.43	2	PARK2, FASLG
regulation of cell projection organization (GO:0031344)	3.38	2	BRAF, PARK2
positive regulation of cell projection organization (GO:0031346)	3.99	2	BRAF, PARK2
single-organism catabolic process (GO:0044712)	3.21	2	CYP2A6, PARK2
regulation of actin filament bundle assembly (GO:0032231)	5.37	2	BRAF, PARK2
negative regulation of cell cycle (GO:0045786)	3.67	2	IRF1, RASSF1
positive regulation of cell cycle (GO:0045787)	3.94	2	EGFR, RASSF1
cellular response to growth factor stimulus (GO:0071363)	4.27	2	ERBB2, EGFR
regulation of cytoskeleton organization (GO:0051493)	3.72	2	BRAF, PARK2
peptidyl-amino acid modification (GO:0018193)	2.98	2	ERBB2, EGFR
regulation of neuron differentiation (GO:0045664)	3.39	2	BRAF, PARK2
positive regulation of neuron differentiation (GO:0045666)	3.98	2	BRAF, PARK2
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817)	5.27	2	PARK2, CASP8
positive regulation of cell development (GO:0010720)	3.57	2	BRAF, PARK2
negative regulation of molecular function (GO:0044092)	2.74	2	PARK2, CASP8
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	2	CASP8, FASLG
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	4.96	2	CASP8, FASLG
T cell costimulation (GO:0031295)	5.35	2	MAP3K8, PIK3CA
modulation by virus of host process (GO:0019054)	6.51	2	PARK2, CASP8
regulation of DNA metabolic process (GO:0051052)	3.87	2	EGFR, PIK3CA
negative regulation of transport (GO:0051051)	3.6	2	BRAF, PARK2
T cell differentiation (GO:0030217)	5.11	2	IRF1, BRAF
regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	5.84	2	PARK2, CASP8
protein heterooligomerization (GO:0051291)	5.22	2	BRAF, CASP8
regulation of T cell proliferation (GO:0042129)	4.74	2	ERBB2, IRF1
establishment of protein localization (GO:0045184)	2.53	2	BRAF, EGFR
developmental process involved in reproduction (GO:0003006)	3.36	2	CASP8, EGFR
single organism reproductive process (GO:0044702)	2.73	2	CASP8, EGFR
positive regulation of neuron projection development (GO:0010976)	4.26	2	BRAF, PARK2
regulation of neuron projection development (GO:0010975)	3.69	2	BRAF, PARK2
interaction with symbiont (GO:0051702)	5.76	2	PARK2, CASP8
interaction with host (GO:0051701)	4.86	2	PARK2, CASP8
neuron projection guidance (GO:0097485)	4.43	2	ERBB2, KRAS
negative regulation of hemopoiesis (GO:1903707)	4.96	2	ERBB2, IRF1
positive regulation of defense response (GO:0031349)	3.83	2	KRAS, CASP8
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	2	KRAS, PIK3CA
vesicle-mediated transport (GO:0016192)	2.72	2	EGFR, PIK3CA
negative regulation of T cell differentiation (GO:0045581)	6.26	2	ERBB2, IRF1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	2	ERCC6, EGFR
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	BRAF, PARK2
response to hormone (GO:0009725)	3.33	2	BRAF, KRAS
regulation of neurotransmitter levels (GO:0001505)	4.77	2	BRAF, PARK2
regulation of cell morphogenesis (GO:0022604)	3.4	2	BRAF, PARK2
regulation of catabolic process (GO:0009894)	3.52	2	PARK2, EGFR
modulation by symbiont of host cellular process (GO:0044068)	6.4	2	PARK2, CASP8
cellular response to mechanical stimulus (GO:0071260)	5.33	2	IRF1, CASP8
organelle disassembly (GO:1903008)	4.52	2	PARK2, PIK3CA
protein stabilization (GO:0050821)	4.86	2	PARK2, RASSF1
regulation of vasculature development (GO:1901342)	4.26	2	ERBB2, FASLG
regulation of secretion by cell (GO:1903530)	3.28	2	BRAF, PARK2
regulation of mononuclear cell proliferation (GO:0032944)	4.45	2	ERBB2, IRF1
negative regulation of neurotransmitter transport (GO:0051589)	6.96	2	BRAF, PARK2
regulation of neurotransmitter transport (GO:0051588)	5.55	2	BRAF, PARK2
positive regulation of protein transport (GO:0051222)	3.61	2	ERBB2, EGFR
organic substance catabolic process (GO:1901575)	2.45	2	CYP2A6, PARK2
negative regulation of catalytic activity (GO:0043086)	3.0	2	PARK2, CASP8
positive regulation of GTPase activity (GO:0043547)	3.28	2	ERBB2, EGFR
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	KRAS, PIK3CA
regulation of peptidase activity (GO:0052547)	3.75	2	CASP8, FASLG
protein autophosphorylation (GO:0046777)	4.46	2	ERBB2, EGFR
mitochondrion disassembly (GO:0061726)	4.63	2	PARK2, PIK3CA
regulation of epithelial cell apoptotic process (GO:1904035)	5.63	2	BRAF, FASLG
negative regulation of immune system process (GO:0002683)	3.85	2	ERBB2, IRF1
transcription from RNA polymerase II promoter (GO:0006366)	3.38	2	IRF1, ERCC6
cellular response to abiotic stimulus (GO:0071214)	4.15	2	IRF1, CASP8
organ morphogenesis (GO:0009887)	3.55	2	BRAF, EGFR
regulation of cellular component biogenesis (GO:0044087)	3.08	2	BRAF, PARK2
response to cytokine (GO:0034097)	3.84	2	IRF1, CASP8
regulation of monooxygenase activity (GO:0032768)	5.69	2	KRAS, EGFR
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	2	PARK2, EGFR
tissue development (GO:0009888)	3.27	2	EGFR, PIK3CA
cell cycle arrest (GO:0007050)	4.69	2	IRF1, RASSF1
associative learning (GO:0008306)	5.44	2	BRAF, KRAS
regulation of actin cytoskeleton organization (GO:0032956)	4.09	2	BRAF, PARK2
positive regulation of neuron death (GO:1901216)	5.52	2	PARK2, FASLG
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	2	PARK2, CASP8
Fc-epsilon receptor signaling pathway (GO:0038095)	4.84	2	KRAS, PIK3CA
endocytosis (GO:0006897)	3.69	2	EGFR, PIK3CA
Fc receptor signaling pathway (GO:0038093)	4.45	2	KRAS, PIK3CA
cellular response to nitrogen compound (GO:1901699)	3.79	2	PARK2, EGFR
innate immune response-activating signal transduction (GO:0002758)	4.45	2	KRAS, CASP8
negative regulation of leukocyte activation (GO:0002695)	4.79	2	ERBB2, IRF1
positive regulation of nervous system development (GO:0051962)	3.64	2	BRAF, PARK2
positive regulation of leukocyte activation (GO:0002696)	4.0	2	MAP3K8, PIK3CA
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	ERBB2, EGFR
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	6.2	2	CASP8, FASLG
regulation of developmental growth (GO:0048638)	4.04	2	PARK2, PIK3CA
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	5.72	2	CASP8, FASLG
cellular response to metal ion (GO:0071248)	4.81	2	BRAF, PARK2
regulation of synapse structure or activity (GO:0050803)	4.77	2	BRAF, KRAS
peptidyl-tyrosine modification (GO:0018212)	4.47	2	ERBB2, EGFR
ion homeostasis (GO:0050801)	3.42	2	PARK2, FASLG
immune response (GO:0006955)	2.86	2	IRF1, FASLG
cellular response to inorganic substance (GO:0071241)	4.67	2	BRAF, PARK2
negative regulation of synaptic transmission (GO:0050805)	5.67	2	BRAF, PARK2
regulation of T cell differentiation (GO:0045580)	5.07	2	ERBB2, IRF1
negative regulation of intracellular signal transduction (GO:1902532)	3.63	2	PARK2, CASP8
regulation of protein catabolic process (GO:0042176)	3.83	2	PARK2, EGFR
response to UV (GO:0009411)	4.88	2	ERCC6, EGFR
negative regulation of secretion by cell (GO:1903531)	4.55	2	BRAF, PARK2
regulation of response to cytokine stimulus (GO:0060759)	4.77	2	PARK2, CASP8
axon guidance (GO:0007411)	4.44	2	ERBB2, KRAS
response to mechanical stimulus (GO:0009612)	4.41	2	IRF1, CASP8
regulation of GTPase activity (GO:0043087)	3.21	2	ERBB2, EGFR
visual learning (GO:0008542)	5.92	2	BRAF, KRAS
cell cycle (GO:0007049)	3.14	2	MAP3K8, RASSF1
regulation of neurogenesis (GO:0050767)	3.21	2	BRAF, PARK2
small GTPase mediated signal transduction (GO:0007264)	3.85	2	KRAS, RASSF1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	PARK2, FASLG
regulation of cell cycle process (GO:0010564)	3.5	2	EGFR, RASSF1
regulation of cell development (GO:0060284)	3.01	2	BRAF, PARK2
positive regulation of neurogenesis (GO:0050769)	3.77	2	BRAF, PARK2
negative regulation of leukocyte cell-cell adhesion (GO:1903038)	5.19	2	ERBB2, IRF1
positive regulation of leukocyte cell-cell adhesion (GO:1903039)	4.35	2	MAP3K8, PIK3CA
positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	4.48	2	PARK2, RASSF1
positive regulation of protein ubiquitination (GO:0031398)	4.55	2	PARK2, RASSF1
regulation of protein ubiquitination (GO:0031396)	4.22	2	PARK2, RASSF1
negative regulation of lymphocyte differentiation (GO:0045620)	6.04	2	ERBB2, IRF1
cellular response to endogenous stimulus (GO:0071495)	3.33	2	PARK2, EGFR
cellular response to external stimulus (GO:0071496)	4.2	2	IRF1, CASP8
tube morphogenesis (GO:0035239)	4.35	2	KRAS, EGFR
cell proliferation (GO:0008283)	3.23	2	ERBB2, EGFR
regulation of stress-activated protein kinase signaling cascade (GO:0070302)	4.44	2	PARK2, ERCC6
macroautophagy (GO:0016236)	4.3	2	PARK2, PIK3CA
regulation of actin filament-based process (GO:0032970)	3.97	2	BRAF, PARK2
regulation of endothelial cell apoptotic process (GO:2000351)	5.99	2	BRAF, FASLG
positive regulation of T cell activation (GO:0050870)	4.39	2	MAP3K8, PIK3CA
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	ERBB2, EGFR
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	ERCC6, RASSF1
regulation of establishment of protein localization to mitochondrion (GO:1903747)	4.88	2	PARK2, CASP8
negative regulation of neurotransmitter secretion (GO:0046929)	7.33	2	BRAF, PARK2
regulation of neurotransmitter secretion (GO:0046928)	5.78	2	BRAF, PARK2
positive regulation of cysteine-type endopeptidase activity (GO:2001056)	4.88	2	CASP8, FASLG
proteolysis (GO:0006508)	2.73	2	PARK2, CASP8
cation homeostasis (GO:0055080)	3.46	2	PARK2, FASLG
cellular chemical homeostasis (GO:0055082)	3.4	2	FASLG, PIK3CA
response to oxidative stress (GO:0006979)	3.9	2	PARK2, ERCC6
protein oligomerization (GO:0051259)	3.71	2	BRAF, CASP8
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	PARK2, CASP8
regulation of epithelial cell proliferation (GO:0050678)	4.06	2	ERBB2, EGFR
positive regulation of epithelial cell proliferation (GO:0050679)	4.67	2	ERBB2, EGFR
mitophagy (GO:0000422)	4.63	2	PARK2, PIK3CA
macromitophagy (GO:0000423)	4.85	2	PARK2, PIK3CA
positive regulation of lymphocyte activation (GO:0051251)	4.07	2	MAP3K8, PIK3CA
negative regulation of lymphocyte activation (GO:0051250)	4.95	2	ERBB2, IRF1
regulation of lymphocyte proliferation (GO:0050670)	4.46	2	ERBB2, IRF1
regulation of synaptic plasticity (GO:0048167)	4.78	2	BRAF, KRAS
response to molecule of bacterial origin (GO:0002237)	3.99	2	CASP8, FASLG
regulation of lymphocyte differentiation (GO:0045619)	4.84	2	ERBB2, IRF1
lymphocyte differentiation (GO:0030098)	4.49	2	IRF1, BRAF
cell cycle process (GO:0022402)	2.75	2	IRF1, RASSF1
gland development (GO:0048732)	4.15	2	BRAF, PIK3CA
lymphocyte costimulation (GO:0031294)	5.33	2	MAP3K8, PIK3CA
visual behavior (GO:0007632)	5.82	2	BRAF, KRAS
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	5.26	2	BRAF, PIK3CA
negative regulation of T cell activation (GO:0050868)	5.26	2	ERBB2, IRF1
extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)	6.09	2	CASP8, FASLG
regulation of JNK cascade (GO:0046328)	4.65	2	PARK2, ERCC6
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	2	BRAF, PIK3CA
positive regulation of cell activation (GO:0050867)	3.97	2	MAP3K8, PIK3CA
negative regulation of cell activation (GO:0050866)	4.67	2	ERBB2, IRF1
modulation by virus of host morphology or physiology (GO:0019048)	6.12	2	PARK2, CASP8
extrinsic apoptotic signaling pathway (GO:0097191)	5.16	2	CASP8, FASLG
peptidyl-tyrosine phosphorylation (GO:0018108)	4.48	2	ERBB2, EGFR
regulation of epidermal growth factor receptor signaling pathway (GO:0042058)	5.33	2	FASLG, EGFR
leukocyte migration (GO:0050900)	4.19	2	KRAS, PIK3CA
modification by host of symbiont morphology or physiology (GO:0051851)	5.8	2	PARK2, CASP8
regulation of mitochondrion organization (GO:0010821)	4.34	2	PARK2, CASP8
positive regulation of mitochondrion organization (GO:0010822)	4.61	2	PARK2, CASP8
regulation of ERBB signaling pathway (GO:1901184)	5.3	2	FASLG, EGFR
negative regulation of cell-cell adhesion (GO:0022408)	4.84	2	ERBB2, IRF1
positive regulation of cell-cell adhesion (GO:0022409)	4.23	2	MAP3K8, PIK3CA
morphogenesis of an epithelium (GO:0002009)	4.08	2	KRAS, EGFR
response to estradiol (GO:0032355)	4.73	2	CASP8, EGFR
activation of innate immune response (GO:0002218)	4.41	2	KRAS, CASP8
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	2	CASP8, FASLG
regulation of cytokine-mediated signaling pathway (GO:0001959)	4.82	2	PARK2, CASP8
response to toxic substance (GO:0009636)	4.88	2	PARK2, ERCC6
regulation of angiogenesis (GO:0045765)	4.36	2	ERBB2, FASLG
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001267)	6.64	2	CASP8, FASLG
regulation of leukocyte proliferation (GO:0070663)	4.4	2	ERBB2, IRF1
regulation of nervous system development (GO:0051960)	3.1	2	BRAF, PARK2
tissue morphogenesis (GO:0048729)	3.87	2	KRAS, EGFR
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001269)	6.9	2	CASP8, FASLG
regulation of cell migration (GO:0030334)	3.23	2	BRAF, EGFR
positive regulation of innate immune response (GO:0045089)	4.22	2	KRAS, CASP8
response to lipopolysaccharide (GO:0032496)	4.03	2	CASP8, FASLG
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	5.26	2	CASP8, FASLG
regulation of endopeptidase activity (GO:0052548)	3.8	2	CASP8, FASLG
autophagy (GO:0006914)	3.82	2	PARK2, PIK3CA
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	2	BRAF, EGFR
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	ERBB2, EGFR
regulation of protein modification by small protein conjugation or removal (GO:1903320)	4.14	2	PARK2, RASSF1
reproductive process (GO:0022414)	2.55	2	CASP8, EGFR
positive regulation of endopeptidase activity (GO:0010950)	4.78	2	CASP8, FASLG
Ras protein signal transduction (GO:0007265)	4.76	2	KRAS, RASSF1
positive regulation of peptidase activity (GO:0010952)	4.7	2	CASP8, FASLG
catabolic process (GO:0009056)	2.38	2	CYP2A6, PARK2
modification by symbiont of host morphology or physiology (GO:0044003)	5.92	2	PARK2, CASP8
cellular catabolic process (GO:0044248)	2.62	2	CYP2A6, PARK2
regulation of nitric-oxide synthase activity (GO:0050999)	5.9	2	KRAS, EGFR
regulation of stress-activated MAPK cascade (GO:0032872)	4.45	2	PARK2, ERCC6
establishment of protein localization to membrane (GO:0090150)	4.14	2	BRAF, EGFR
modification of morphology or physiology of other organism (GO:0035821)	5.12	2	PARK2, CASP8
negative regulation of leukocyte differentiation (GO:1902106)	5.3	2	ERBB2, IRF1
regulation of synaptic vesicle transport (GO:1902803)	6.29	2	BRAF, PARK2
immune effector process (GO:0002252)	3.58	2	IRF1, PIK3CA
regulation of translation (GO:0006417)	3.96	2	ERBB2, EGFR
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097296)	7.16	2	CASP8, FASLG
cellular response to organonitrogen compound (GO:0071417)	3.87	2	PARK2, EGFR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of intracellular protein transport (GO:0033157)	-	3.8	0.007	CASP8, IRF1, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	-	4.69	0.0	CASP8, IRF1, PPP2R1B, ERBB2, KRAS, EGFR, FASLG
cytokine-mediated signaling pathway (GO:0019221)	-	3.6	0.035	IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
regulation of apoptotic signaling pathway (GO:2001233)	-	3.83	0.0	KRAS, CASP8, IRF1, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
regulation of T cell apoptotic process (GO:0070232)	NEW	6.2	0.003	KRAS, CASP8, EGFR, PIK3CA
protein dephosphorylation (GO:0006470)	NEW	4.47	0.043	ERBB2, CASP8, PARK2, EGFR, FASLG
regulation of intracellular transport (GO:0032386)	-	3.58	0.018	KRAS, CASP8, IRF1, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
positive regulation of response to stimulus (GO:0048584)	-	2.18	0.0	KRAS, ERCC6, CASP8, BRAF, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
learning (GO:0007612)	-	4.85	0.001	BRAF, PARK2, KRAS, ERBB2, EGFR, FASLG
activation of protein kinase activity (GO:0032147)	-	4.08	0.0	ERCC6, CASP8, MAP3K8, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
alpha-beta T cell activation (GO:0046631)	-	5.92	0.015	IRF1, KRAS, BRAF, FASLG
learning or memory (GO:0007611)	-	4.33	0.033	BRAF, PARK2, KRAS, ERBB2, EGFR, FASLG
nucleotide catabolic process (GO:0009166)	NEW	5.67	0.01	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
nucleoside catabolic process (GO:0009164)	NEW	6.17	0.009	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of neuron apoptotic process (GO:0043523)	-	4.47	0.001	CASP8, BRAF, PARK2, PIK3CA, KRAS, EGFR, FASLG
negative regulation of neuron apoptotic process (GO:0043524)	-	4.82	0.007	CASP8, BRAF, PARK2, KRAS, PIK3CA, EGFR
GTP metabolic process (GO:0046039)	NEW	6.59	0.039	BRAF, PARK2, KRAS, ERBB2, PIK3CA, EGFR
T cell activation (GO:0042110)	-	4.45	0.043	CASP8, IRF1, KRAS, EGFR, BRAF, FASLG
enzyme linked receptor protein signaling pathway (GO:0007167)	-	3.24	0.009	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	-	3.54	0.0	KRAS, CASP8, MAP3K8, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
negative regulation of cell projection organization (GO:0031345)	NEW	4.72	0.032	FASLG, ERBB2, KRAS, EGFR, PIK3CA
regulation of alpha-beta T cell proliferation (GO:0046640)	NEW	6.51	0.034	IRF1, FASLG, EGFR
signal transduction by phosphorylation (GO:0023014)	-	3.79	0.001	CASP8, MAP3K8, PIK3CA, ERBB2, KRAS, EGFR, BRAF
organophosphate catabolic process (GO:0046434)	NEW	5.03	0.002	KRAS, EGFR, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
response to inorganic substance (GO:0010035)	-	3.56	0.001	EGFR, CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, FASLG
negative regulation of cell cycle (GO:0045786)	-	3.67	0.0	KRAS, CASP8, IRF1, RASSF1, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
positive regulation of macromolecule metabolic process (GO:0010604)	-	1.81	0.0	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
negative regulation of signal transduction (GO:0009968)	-	2.75	0.007	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
positive regulation of cell adhesion (GO:0045785)	-	3.79	0.015	IRF1, PIK3CA, ERBB2, EGFR, BRAF, FASLG
regulation of signal transduction (GO:0009966)	-	1.84	0.0	ERCC6, CASP8, IRF1, PARK2, PPP2R1B, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
positive regulation of signal transduction (GO:0009967)	-	2.5	0.003	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
response to bacterium (GO:0009617)	NEW	4.18	0.014	CASP8, IRF1, PIK3CA, ERBB2, EGFR, FASLG
MAPK cascade (GO:0000165)	-	3.91	0.0	CASP8, MAP3K8, PIK3CA, ERBB2, KRAS, EGFR, BRAF
response to wounding (GO:0009611)	NEW	4.39	0.014	CASP8, MAP3K8, ERBB2, EGFR, BRAF, FASLG
peptidyl-amino acid modification (GO:0018193)	-	2.98	0.0	KRAS, EGFR, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, PPP2R1B, ERCC6, IRF1, FASLG
Ras protein signal transduction (GO:0007265)	-	4.76	0.0	KRAS, BRAF, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
ribonucleoside triphosphate metabolic process (GO:0009199)	NEW	4.77	0.012	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
hypothalamus development (GO:0021854)	NEW	6.96	0.007	ERBB2, EGFR, FASLG
positive regulation of molecular function (GO:0044093)	-	2.23	0.004	ERCC6, CASP8, MAP3K8, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
phosphorylation (GO:0016310)	-	2.63	0.011	KRAS, CASP8, MAP3K8, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
response to fungicide (GO:0060992)	NEW	7.24	0.042	ERBB2, EGFR
nucleoside triphosphate metabolic process (GO:0009141)	NEW	4.61	0.015	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	-	4.27	0.015	CASP8, PARK2, KRAS, PIK3CA, EGFR, FASLG
purine ribonucleoside triphosphate catabolic process (GO:0009207)	NEW	9.73	0.004	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of small GTPase mediated signal transduction (GO:0051056)	NEW	4.08	0.031	CASP8, KRAS, ERBB2, PIK3CA, EGFR, FASLG
purine ribonucleoside triphosphate metabolic process (GO:0009205)	NEW	4.81	0.011	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
neurotrophin signaling pathway (GO:0038179)	NEW	6.55	0.004	CASP8, BRAF, PIK3CA, ERBB2, KRAS, EGFR, FASLG
positive regulation of transport (GO:0051050)	-	2.9	0.011	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
negative regulation of cell death (GO:0060548)	-	2.95	0.012	CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
regulation of protein kinase activity (GO:0045859)	-	3.15	0.002	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
regulation of T cell proliferation (GO:0042129)	-	4.74	0.002	CASP8, IRF1, KRAS, ERBB2, EGFR, FASLG
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239)	NEW	5.86	0.0	CASP8, IRF1, PPP2R1B, ERBB2, EGFR, FASLG
spermatogenesis (GO:0007283)	NEW	3.7	0.015	KRAS, CASP8, PARK2, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
lymphocyte activation (GO:0046649)	-	3.96	0.041	CASP8, IRF1, KRAS, ERBB2, EGFR, BRAF, FASLG
epidermal growth factor receptor signaling pathway (GO:0007173)	-	5.72	0.027	ERBB2, KRAS, EGFR, PIK3CA
positive regulation of neuron projection development (GO:0010976)	-	4.26	0.008	PPP2R1B, FASLG, EGFR, PIK3CA, BRAF
response to metal ion (GO:0010038)	-	3.91	0.009	CASP8, BRAF, PARK2, PIK3CA, KRAS, EGFR, FASLG
negative regulation of axonogenesis (GO:0050771)	NEW	5.52	0.019	ERBB2, KRAS, EGFR, FASLG
response to peptide hormone (GO:0043434)	NEW	4.06	0.005	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF
purine ribonucleoside metabolic process (GO:0046128)	NEW	4.33	0.032	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
negative regulation of cell migration (GO:0030336)	NEW	4.41	0.001	CASP8, IRF1, KRAS, ERBB2, EGFR, BRAF, FASLG
ribonucleoside catabolic process (GO:0042454)	NEW	6.55	0.007	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of phosphorylation (GO:0042325)	-	2.5	0.004	EGFR, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF
positive regulation of signaling (GO:0023056)	-	2.41	0.0	EGFR, CASP8, BRAF, PARK2, PPP2R1B, ERBB2, KRAS, ERCC6, FASLG
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.002	KRAS, ERCC6, CASP8, MAP3K8, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, IRF1, FASLG
negative regulation of phosphorylation (GO:0042326)	NEW	3.7	0.0	CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
organonitrogen compound catabolic process (GO:1901565)	NEW	3.91	0.002	KRAS, EGFR, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF, FASLG
negative regulation of signaling (GO:0023057)	-	2.65	0.012	KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	NEW	4.62	0.005	EGFR, IRF1, PIK3CA, ERBB2, ERCC6, FASLG
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	-	4.35	0.001	EGFR, IRF1, PIK3CA, ERBB2, KRAS, ERCC6, FASLG
response to organonitrogen compound (GO:0010243)	-	3.2	0.0	KRAS, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
positive regulation of organelle organization (GO:0010638)	-	3.38	0.006	CASP8, IRF1, PARK2, KRAS, ERBB2, EGFR, BRAF, FASLG
immune system process (GO:0002376)	-	2.29	0.015	CASP8, IRF1, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
positive regulation of cellular component movement (GO:0051272)	NEW	3.71	0.002	KRAS, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
regulation of cell motility (GO:2000145)	-	3.16	0.0	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
response to hormone (GO:0009725)	-	3.33	0.017	KRAS, CASP8, IRF1, PPP2R1B, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
aromatic compound catabolic process (GO:0019439)	NEW	3.79	0.0	CYP2A6, KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
negative regulation of cell communication (GO:0010648)	-	2.66	0.012	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
negative regulation of kinase activity (GO:0033673)	NEW	4.22	0.028	CASP8, PARK2, PIK3CA, ERBB2, EGFR, FASLG
ribonucleoside triphosphate catabolic process (GO:0009203)	NEW	9.73	0.004	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
negative regulation of catabolic process (GO:0009895)	NEW	4.81	0.048	ERBB2, CASP8, PARK2, EGFR, PIK3CA
positive regulation of metabolic process (GO:0009893)	-	1.74	0.001	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
negative regulation of neuron death (GO:1901215)	-	4.57	0.0	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
positive regulation of kinase activity (GO:0033674)	-	3.54	0.0	KRAS, EGFR, CASP8, MAP3K8, PPP2R1B, ERBB2, PIK3CA, ERCC6, BRAF, FASLG
regulation of lymphocyte proliferation (GO:0050670)	-	4.46	0.014	IRF1, KRAS, ERBB2, PIK3CA, EGFR, FASLG
cellular response to mechanical stimulus (GO:0071260)	-	5.33	0.034	IRF1, CASP8, EGFR, PIK3CA
regulation of signaling (GO:0023051)	-	1.72	0.002	EGFR, CASP8, IRF1, PARK2, PPP2R1B, BRAF, ERBB2, KRAS, ERCC6, MAP3K8, FASLG
purine nucleoside triphosphate metabolic process (GO:0009144)	NEW	4.76	0.011	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
positive regulation of cell migration (GO:0030335)	NEW	3.77	0.001	KRAS, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
purine nucleoside triphosphate catabolic process (GO:0009146)	NEW	7.94	0.004	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
protein stabilization (GO:0050821)	-	4.86	0.003	IRF1, MAP3K8, KRAS, EGFR, RASSF1
leukocyte activation (GO:0045321)	-	3.76	0.016	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
regulation of synaptic plasticity (GO:0048167)	-	4.78	0.035	ERBB2, KRAS, EGFR, FASLG, BRAF
regulation of cell migration (GO:0030334)	-	3.23	0.0	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
positive regulation of mononuclear cell proliferation (GO:0032946)	NEW	4.84	0.001	IRF1, KRAS, ERBB2, PIK3CA, EGFR, FASLG
defense response to bacterium (GO:0042742)	NEW	4.31	0.005	CASP8, IRF1, PIK3CA, ERBB2, EGFR, FASLG
regulation of mononuclear cell proliferation (GO:0032944)	-	4.45	0.014	IRF1, KRAS, ERBB2, PIK3CA, EGFR, FASLG
positive regulation of ERBB signaling pathway (GO:1901186)	NEW	6.15	0.033	ERBB2, EGFR, FASLG
positive regulation of protein serine/threonine kinase activity (GO:0071902)	-	4.06	0.0	KRAS, ERCC6, CASP8, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
intracellular signal transduction (GO:0035556)	-	2.39	0.003	KRAS, EGFR, CASP8, MAP3K8, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of protein serine/threonine kinase activity (GO:0071900)	-	3.58	0.001	KRAS, EGFR, CASP8, PARK2, PIK3CA, ERBB2, PPP2R1B, ERCC6, FASLG
regulation of apoptotic process (GO:0042981)	-	2.5	0.009	KRAS, CASP8, BRAF, PARK2, PIK3CA, PPP2R1B, EGFR, FASLG
response to cytokine (GO:0034097)	-	3.84	0.017	CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
positive regulation of transferase activity (GO:0051347)	-	3.31	0.0	KRAS, ERCC6, CASP8, IRF1, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
positive regulation of GTPase activity (GO:0043547)	-	3.28	0.017	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
positive regulation of hydrolase activity (GO:0051345)	-	2.91	0.021	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
cellular response to tumor necrosis factor (GO:0071356)	NEW	5.19	0.008	IRF1, EGFR, PIK3CA, FASLG, BRAF
purine ribonucleoside catabolic process (GO:0046130)	NEW	7.16	0.006	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of kinase activity (GO:0043549)	-	3.07	0.0	KRAS, EGFR, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, ERCC6, BRAF, FASLG
cellular response to fibroblast growth factor stimulus (GO:0044344)	NEW	6.4	0.001	ERBB2, KRAS, EGFR, PIK3CA, BRAF
guanosine-containing compound catabolic process (GO:1901069)	NEW	8.63	0.029	BRAF, PARK2, KRAS, ERBB2, PIK3CA, EGFR
nucleoside triphosphate catabolic process (GO:0009143)	NEW	7.24	0.005	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
negative regulation of MAPK cascade (GO:0043409)	NEW	4.74	0.001	CASP8, BRAF, PARK2, KRAS, PIK3CA, EGFR
regulation of protein tyrosine kinase activity (GO:0061097)	NEW	5.59	0.018	ERBB2, ERCC6, EGFR, PIK3CA
positive regulation of protein tyrosine kinase activity (GO:0061098)	NEW	6.07	0.003	ERBB2, ERCC6, EGFR, PIK3CA
regulation of molecular function (GO:0065009)	-	1.78	0.022	EGFR, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF, FASLG
cellular response to abiotic stimulus (GO:0071214)	-	4.15	0.007	CASP8, IRF1, PIK3CA, ERBB2, EGFR, BRAF, FASLG
negative regulation of intracellular signal transduction (GO:1902532)	-	3.63	0.0	KRAS, CASP8, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
response to tumor necrosis factor (GO:0034612)	NEW	4.93	0.027	FASLG, CASP8, EGFR, PIK3CA, BRAF
positive regulation of cellular component organization (GO:0051130)	-	2.68	0.024	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
regulation of catalytic activity (GO:0050790)	-	1.97	0.004	EGFR, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, ERCC6, BRAF, FASLG
purine nucleotide catabolic process (GO:0006195)	NEW	6.07	0.008	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
lipid metabolic process (GO:0006629)	-	2.68	0.013	CYP2A6, KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
purine ribonucleotide catabolic process (GO:0009154)	NEW	6.47	0.007	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
catecholamine metabolic process (GO:0006584)	NEW	6.02	0.008	IRF1, PARK2, BRAF, EGFR
purine ribonucleotide metabolic process (GO:0009150)	NEW	4.16	0.05	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
positive regulation of MAPK cascade (GO:0043410)	-	3.57	0.0	ERCC6, CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
regulation of leukocyte proliferation (GO:0070663)	-	4.4	0.016	IRF1, KRAS, ERBB2, PIK3CA, EGFR, FASLG
regulation of anatomical structure morphogenesis (GO:0022603)	-	2.79	0.026	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
inflammatory response (GO:0006954)	NEW	3.64	0.01	KRAS, CASP8, BRAF, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
neurotrophin TRK receptor signaling pathway (GO:0048011)	NEW	6.96	0.003	CASP8, BRAF, PIK3CA, ERBB2, KRAS, EGFR, FASLG
nucleobase-containing compound catabolic process (GO:0034655)	NEW	3.9	0.002	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
regulation of neuron death (GO:1901214)	-	4.19	0.001	FASLG, PARK2, KRAS, PIK3CA, BRAF
regulation of intracellular signal transduction (GO:1902531)	-	2.31	0.001	EGFR, CASP8, MAP3K8, PARK2, KRAS, ERBB2, ERCC6, BRAF, FASLG
leukocyte differentiation (GO:0002521)	-	4.13	0.0	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
ribonucleotide catabolic process (GO:0009261)	NEW	6.43	0.007	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
endocytosis (GO:0006897)	-	3.69	0.043	CASP8, MAP3K8, PIK3CA, ERBB2, KRAS, EGFR, FASLG
cellular nitrogen compound catabolic process (GO:0044270)	NEW	3.8	0.003	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
protein maturation (GO:0051604)	NEW	4.48	0.031	CASP8, PARK2, KRAS, PIK3CA, EGFR, FASLG
cellular response to cytokine stimulus (GO:0071345)	NEW	4.33	0.042	IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
response to nitrogen compound (GO:1901698)	-	3.12	0.0	KRAS, CASP8, IRF1, PARK2, PPP2R1B, PIK3CA, BRAF, ERBB2, RASSF1, EGFR, MAP3K8, FASLG
positive regulation of protein modification process (GO:0031401)	-	2.7	0.0	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, IRF1, BRAF, FASLG
regulation of transferase activity (GO:0051338)	-	2.88	0.0	KRAS, EGFR, CASP8, MAP3K8, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, ERCC6, IRF1, FASLG
regulation of leukocyte activation (GO:0002694)	-	3.6	0.001	KRAS, CASP8, IRF1, PPP2R1B, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
positive regulation of leukocyte activation (GO:0002696)	-	4.0	0.001	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, MAP3K8, FASLG
nucleoside phosphate catabolic process (GO:1901292)	NEW	5.54	0.011	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
regulation of nucleocytoplasmic transport (GO:0046822)	NEW	4.33	0.023	IRF1, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
positive regulation of cell motility (GO:2000147)	NEW	3.74	0.001	KRAS, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
negative regulation of cell motility (GO:2000146)	NEW	4.36	0.001	CASP8, IRF1, KRAS, ERBB2, EGFR, BRAF, FASLG
response to fibroblast growth factor (GO:0071774)	NEW	6.17	0.001	ERBB2, KRAS, EGFR, PIK3CA, BRAF
nucleoside phosphate metabolic process (GO:0006753)	NEW	3.71	0.031	KRAS, ERCC6, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1
organic hydroxy compound metabolic process (GO:1901615)	NEW	3.84	0.001	KRAS, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, EGFR, BRAF, FASLG
catechol-containing compound metabolic process (GO:0009712)	NEW	6.02	0.008	IRF1, PARK2, BRAF, EGFR
response to radiation (GO:0009314)	-	3.69	0.003	ERCC6, CASP8, IRF1, PPP2R1B, ERBB2, KRAS, EGFR, BRAF, FASLG
regulation of synaptic transmission (GO:0050804)	-	4.09	0.007	BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
negative regulation of protein modification process (GO:0031400)	NEW	3.4	0.011	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
positive regulation of MAP kinase activity (GO:0043406)	-	4.39	0.03	ERBB2, KRAS, ERCC6, EGFR
regulation of MAP kinase activity (GO:0043405)	-	3.95	0.0	KRAS, EGFR, CASP8, PARK2, PIK3CA, ERBB2, PPP2R1B, ERCC6, FASLG
response to light stimulus (GO:0009416)	-	4.08	0.0	EGFR, CASP8, IRF1, PPP2R1B, ERBB2, KRAS, ERCC6, BRAF, FASLG
ERBB signaling pathway (GO:0038127)	-	5.36	0.029	ERBB2, KRAS, EGFR, PIK3CA
positive regulation of intracellular signal transduction (GO:1902533)	-	2.95	0.0	KRAS, EGFR, CASP8, IRF1, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF, FASLG
positive regulation of cell communication (GO:0010647)	-	2.41	0.0	EGFR, CASP8, BRAF, PARK2, PPP2R1B, ERBB2, KRAS, ERCC6, FASLG
regulation of cell communication (GO:0010646)	-	1.73	0.002	ERCC6, CASP8, IRF1, PARK2, PPP2R1B, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
fibroblast growth factor receptor signaling pathway (GO:0008543)	NEW	5.3	0.0	ERBB2, KRAS, EGFR, PIK3CA, BRAF
response to growth factor (GO:0070848)	-	4.14	0.017	KRAS, CASP8, MAP3K8, PIK3CA, ERBB2, PPP2R1B, EGFR, BRAF, FASLG
positive regulation of catalytic activity (GO:0043085)	-	2.4	0.001	EGFR, CASP8, MAP3K8, PIK3CA, ERBB2, KRAS, ERCC6, BRAF, FASLG
regulation of MAPK cascade (GO:0043408)	-	3.22	0.006	KRAS, ERCC6, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
negative regulation of protein metabolic process (GO:0051248)	-	2.82	0.034	KRAS, CASP8, BRAF, PARK2, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
regulation of lymphocyte activation (GO:0051249)	-	3.73	0.0	KRAS, CASP8, IRF1, PIK3CA, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	-	3.12	0.034	ERCC6, CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.005	KRAS, ERCC6, CASP8, IRF1, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
negative regulation of phosphorus metabolic process (GO:0010563)	NEW	3.45	0.001	CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
regulation of protein metabolic process (GO:0051246)	-	1.93	0.0	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
positive regulation of protein metabolic process (GO:0051247)	-	2.43	0.0	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, IRF1, FASLG
negative regulation of neurogenesis (GO:0050768)	NEW	4.22	0.041	FASLG, ERBB2, KRAS, EGFR, PIK3CA
negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)	NEW	6.26	0.028	ERBB2, PARK2, EGFR, PIK3CA
cellular response to organic cyclic compound (GO:0071407)	-	3.93	0.002	KRAS, CASP8, IRF1, RASSF1, ERBB2, PIK3CA, EGFR, FASLG
positive regulation of cellular protein metabolic process (GO:0032270)	-	2.49	0.0	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
positive regulation of defense response (GO:0031349)	-	3.83	0.002	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, FASLG
regulation of protein modification process (GO:0031399)	-	2.32	0.0	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	NEW	6.17	0.025	ERBB2, EGFR, FASLG
positive regulation of cell activation (GO:0050867)	-	3.97	0.001	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, MAP3K8, FASLG
regulation of sodium ion transport (GO:0002028)	NEW	5.4	0.027	ERBB2, KRAS, BRAF, CASP8
regulation of exocytosis (GO:0017157)	NEW	4.59	0.029	BRAF, KRAS, PARK2, EGFR, PIK3CA
cellular response to endogenous stimulus (GO:0071495)	-	3.33	0.049	KRAS, CASP8, MAP3K8, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
negative regulation of cell proliferation (GO:0008285)	-	3.26	0.0	KRAS, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, DLEC1, FASLG
insulin receptor signaling pathway (GO:0008286)	NEW	5.33	0.001	MAP3K8, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
cellular response to external stimulus (GO:0071496)	-	4.2	0.002	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, FASLG
regulation of protein localization to nucleus (GO:1900180)	NEW	4.34	0.01	IRF1, KRAS, ERBB2, PIK3CA, EGFR, FASLG
neurological system process (GO:0050877)	-	2.64	0.023	KRAS, IRF1, PARK2, PPP2R1B, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
positive regulation of cytokine biosynthetic process (GO:0042108)	NEW	5.65	0.033	ERBB2, CASP8, IRF1, EGFR
cellular response to lipid (GO:0071396)	NEW	3.96	0.033	CASP8, IRF1, PIK3CA, ERBB2, EGFR, BRAF, FASLG
negative regulation of cellular component movement (GO:0051271)	NEW	4.22	0.001	CASP8, IRF1, KRAS, ERBB2, EGFR, BRAF, FASLG
regulation of response to stimulus (GO:0048583)	-	1.54	0.002	KRAS, ERCC6, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
regulation of vesicle-mediated transport (GO:0060627)	-	3.63	0.004	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
positive regulation of ion transport (GO:0043270)	NEW	4.36	0.007	BRAF, PARK2, KRAS, ERBB2, EGFR, FASLG
positive regulation of biological process (GO:0048518)	-	1.2	0.009	KRAS, ERCC6, CASP8, IRF1, PARK2, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8, FASLG
cellular response to hormone stimulus (GO:0032870)	NEW	3.99	0.029	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
regulation of cellular component movement (GO:0051270)	-	3.08	0.0	KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
regulation of T cell activation (GO:0050863)	-	4.05	0.0	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, MAP3K8, FASLG
male gamete generation (GO:0048232)	NEW	3.7	0.016	KRAS, CASP8, PARK2, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
cellular lipid metabolic process (GO:0044255)	-	2.92	0.016	KRAS, ERCC6, CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
bone resorption (GO:0045453)	NEW	6.64	0.039	ERBB2, EGFR, FASLG
negative regulation of cellular protein metabolic process (GO:0032269)	-	2.88	0.007	KRAS, CASP8, BRAF, PARK2, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
regulation of cellular protein metabolic process (GO:0032268)	-	1.99	0.0	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, EGFR, BRAF
cellular response to growth factor stimulus (GO:0071363)	-	4.27	0.012	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460)	NEW	5.57	0.015	FASLG, ERBB2, IRF1, EGFR
positive regulation of lymphocyte activation (GO:0051251)	-	4.07	0.0	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, MAP3K8, FASLG
carbohydrate derivative catabolic process (GO:1901136)	NEW	4.61	0.004	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF, FASLG
response to drug (GO:0042493)	NEW	3.71	0.009	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
positive regulation of lymphocyte proliferation (GO:0050671)	NEW	4.85	0.001	IRF1, KRAS, ERBB2, PIK3CA, EGFR, FASLG
heterocycle catabolic process (GO:0046700)	NEW	3.82	0.0	CYP2A6, KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)	NEW	6.2	0.003	ERBB2, EGFR, IRF1, FASLG
cellular response to DNA damage stimulus (GO:0006974)	-	3.17	0.047	KRAS, ERCC6, CASP8, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
response to organic cyclic compound (GO:0014070)	-	3.07	0.014	KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
lymphocyte differentiation (GO:0030098)	-	4.49	0.017	IRF1, KRAS, ERBB2, EGFR, BRAF, FASLG
positive regulation of protein kinase activity (GO:0045860)	-	3.61	0.0	KRAS, EGFR, CASP8, MAP3K8, PIK3CA, ERBB2, PPP2R1B, ERCC6, BRAF, FASLG
regulation of ERK1 and ERK2 cascade (GO:0070372)	-	4.23	0.006	CASP8, BRAF, PIK3CA, ERBB2, EGFR, FASLG
negative regulation of cytokine production (GO:0001818)	NEW	4.4	0.011	IRF1, PARK2, KRAS, PIK3CA, EGFR, FASLG
activation of MAPKK activity (GO:0000186)	-	5.74	0.0	MAP3K8, KRAS, ERCC6, BRAF, EGFR
regulation of protein stability (GO:0031647)	-	4.33	0.0	CASP8, IRF1, RASSF1, BRAF, ERBB2, KRAS, EGFR, MAP3K8
regulation of cellular localization (GO:0060341)	-	3.03	0.013	KRAS, CASP8, IRF1, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, BRAF, FASLG
regulation of lymphocyte apoptotic process (GO:0070228)	NEW	5.7	0.022	KRAS, CASP8, EGFR, PIK3CA
regulation of cell activation (GO:0050865)	-	3.53	0.002	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR, IRF1, FASLG
regulation of peptidyl-serine phosphorylation (GO:0033135)	-	4.98	0.008	ERBB2, KRAS, EGFR, PIK3CA, BRAF
positive regulation of cellular metabolic process (GO:0031325)	-	1.81	0.001	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
negative regulation of protein phosphorylation (GO:0001933)	NEW	3.79	0.001	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
apoptotic signaling pathway (GO:0097190)	-	4.12	0.002	EGFR, CASP8, IRF1, PIK3CA, ERBB2, KRAS, ERCC6, FASLG
extrinsic apoptotic signaling pathway (GO:0097191)	-	5.16	0.0	CASP8, IRF1, PIK3CA, ERBB2, EGFR, FASLG
peptidyl-tyrosine phosphorylation (GO:0018108)	-	4.48	0.034	FASLG, ERBB2, EGFR, MAP3K8, PIK3CA
positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	-	4.48	0.011	EGFR, KRAS, PARK2, PIK3CA, RASSF1
neuron-neuron synaptic transmission (GO:0007270)	NEW	5.74	0.024	ERBB2, PARK2, EGFR, PIK3CA
positive regulation of cell death (GO:0010942)	-	3.32	0.029	KRAS, CASP8, IRF1, RASSF1, ERBB2, PIK3CA, EGFR, FASLG
cell cycle process (GO:0022402)	-	2.75	0.019	KRAS, CASP8, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, EGFR, IRF1, FASLG
regulation of striated muscle cell apoptotic process (GO:0010662)	NEW	6.64	0.008	ERBB2, FASLG, EGFR
cellular response to insulin stimulus (GO:0032869)	NEW	5.29	0.013	MAP3K8, PPP2R1B, KRAS, ERBB2, PIK3CA, EGFR
response to insulin (GO:0032868)	NEW	4.72	0.004	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, PIK3CA, EGFR
purine-containing compound catabolic process (GO:0072523)	NEW	5.92	0.009	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
single-organism carbohydrate metabolic process (GO:0044723)	NEW	3.42	0.037	KRAS, CASP8, BRAF, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
positive regulation of protein transport (GO:0051222)	-	3.61	0.021	CASP8, IRF1, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
gamete generation (GO:0007276)	NEW	3.61	0.033	KRAS, CASP8, PARK2, PIK3CA, ERBB2, RASSF1, EGFR, FASLG
regulation of protein transport (GO:0051223)	-	3.12	0.037	KRAS, CASP8, IRF1, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
response to mechanical stimulus (GO:0009612)	-	4.41	0.016	CASP8, IRF1, PIK3CA, ERBB2, EGFR, FASLG
proteolysis (GO:0006508)	-	2.73	0.001	KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
cellular response to organonitrogen compound (GO:0071417)	-	3.87	0.001	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, FASLG
T cell differentiation (GO:0030217)	-	5.11	0.022	IRF1, KRAS, FASLG, EGFR, BRAF
response to toxic substance (GO:0009636)	-	4.88	0.004	EGFR, CASP8, BRAF, PARK2, KRAS, ERCC6
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	-	2.6	0.023	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
positive regulation of angiogenesis (GO:0045766)	NEW	4.93	0.038	FASLG, ERBB2, KRAS, EGFR, PIK3CA
positive regulation of apoptotic process (GO:0043065)	-	3.38	0.014	KRAS, CASP8, IRF1, RASSF1, ERBB2, PIK3CA, EGFR, FASLG
regulation of programmed cell death (GO:0043067)	-	2.49	0.01	KRAS, CASP8, BRAF, PARK2, PIK3CA, PPP2R1B, EGFR, FASLG
negative regulation of apoptotic process (GO:0043066)	-	3.04	0.007	CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
positive regulation of leukocyte proliferation (GO:0070665)	NEW	4.79	0.002	IRF1, KRAS, ERBB2, PIK3CA, EGFR, FASLG
regulation of ion transport (GO:0043269)	NEW	3.4	0.027	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
purine nucleoside catabolic process (GO:0006152)	NEW	7.16	0.006	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
purine nucleoside metabolic process (GO:0042278)	NEW	4.32	0.034	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
negative regulation of programmed cell death (GO:0043069)	-	3.02	0.008	CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
positive regulation of programmed cell death (GO:0043068)	-	3.38	0.015	KRAS, CASP8, IRF1, RASSF1, ERBB2, PIK3CA, EGFR, FASLG
cellular response to nitrogen compound (GO:1901699)	-	3.79	0.0	KRAS, CASP8, IRF1, PPP2R1B, PIK3CA, ERBB2, RASSF1, EGFR, MAP3K8, FASLG
protein phosphorylation (GO:0006468)	-	2.89	0.004	KRAS, MAP3K8, PPP2R1B, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
negative regulation of protein kinase activity (GO:0006469)	NEW	4.29	0.021	CASP8, PARK2, PIK3CA, ERBB2, EGFR, FASLG
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	-	2.55	0.028	KRAS, ERCC6, CASP8, IRF1, PARK2, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.005	KRAS, ERCC6, CASP8, IRF1, PIK3CA, BRAF, ERBB2, PPP2R1B, EGFR, MAP3K8, FASLG
negative regulation of phosphate metabolic process (GO:0045936)	NEW	3.45	0.001	CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
innate immune response (GO:0045087)	NEW	3.55	0.031	KRAS, CASP8, IRF1, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
positive regulation of T cell proliferation (GO:0042102)	NEW	5.16	0.006	KRAS, ERBB2, CASP8, EGFR, FASLG
regulation of metal ion transport (GO:0010959)	NEW	3.94	0.0	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
nucleotide metabolic process (GO:0009117)	NEW	3.73	0.029	KRAS, ERCC6, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
positive regulation of T cell activation (GO:0050870)	-	4.39	0.0	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, MAP3K8, FASLG
regulation of GTPase activity (GO:0043087)	-	3.21	0.032	CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
negative regulation of signal transduction in absence of ligand (GO:1901099)	NEW	6.2	0.003	ERBB2, EGFR, IRF1, FASLG
ribonucleoside metabolic process (GO:0009119)	NEW	4.21	0.044	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
positive regulation of peptidase activity (GO:0010952)	-	4.7	0.032	IRF1, CASP8, EGFR, FASLG, BRAF
macromolecule catabolic process (GO:0009057)	NEW	3.0	0.036	CASP8, IRF1, PARK2, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
lipid biosynthetic process (GO:0008610)	NEW	3.49	0.017	KRAS, CASP8, MAP3K8, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
response to oxygen-containing compound (GO:1901700)	-	2.57	0.047	EGFR, CASP8, BRAF, PIK3CA, KRAS, ERCC6, FASLG
cellular response to oxygen-containing compound (GO:1901701)	-	3.22	0.009	KRAS, CASP8, MAP3K8, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
negative regulation of locomotion (GO:0040013)	NEW	4.22	0.004	CASP8, IRF1, KRAS, ERBB2, EGFR, BRAF, FASLG
regulation of locomotion (GO:0040012)	-	3.12	0.0	KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, BRAF, FASLG
positive regulation of locomotion (GO:0040017)	NEW	3.71	0.003	KRAS, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
regulation of cell cycle (GO:0051726)	-	2.93	0.02	KRAS, CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, PIK3CA, IRF1, FASLG
regulation of cell death (GO:0010941)	-	2.43	0.013	KRAS, CASP8, BRAF, PARK2, PIK3CA, PPP2R1B, EGFR, FASLG
peptidyl-tyrosine modification (GO:0018212)	-	4.47	0.035	FASLG, ERBB2, EGFR, MAP3K8, PIK3CA
response to peptide (GO:1901652)	NEW	3.94	0.0	KRAS, CASP8, IRF1, PPP2R1B, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
negative regulation of cellular process (GO:0048523)	-	1.41	0.038	KRAS, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, DLEC1, FASLG
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	-	3.96	0.024	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, FASLG
posttranscriptional regulation of gene expression (GO:0010608)	-	3.64	0.0	KRAS, CASP8, IRF1, PARK2, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, MAP3K8
regulation of defense response (GO:0031347)	-	3.11	0.034	CASP8, IRF1, PIK3CA, ERBB2, KRAS, EGFR, BRAF, FASLG
regulation of protein phosphorylation (GO:0001932)	-	2.57	0.001	KRAS, EGFR, CASP8, MAP3K8, PARK2, PIK3CA, BRAF, ERBB2, PPP2R1B, ERCC6, IRF1, FASLG
alpha-beta T cell differentiation (GO:0046632)	-	6.15	0.008	IRF1, KRAS, BRAF, FASLG
positive regulation of protein phosphorylation (GO:0001934)	-	2.95	0.001	KRAS, EGFR, CASP8, MAP3K8, PIK3CA, BRAF, ERBB2, PPP2R1B, ERCC6, IRF1, FASLG
glycosyl compound catabolic process (GO:1901658)	NEW	6.02	0.009	KRAS, EGFR, MAP3K8, PARK2, RASSF1, ERBB2, PIK3CA, ERCC6, BRAF
positive regulation of cellular process (GO:0048522)	-	1.3	0.002	KRAS, ERCC6, CASP8, MAP3K8, PARK2, RASSF1, BRAF, ERBB2, PPP2R1B, EGFR, PIK3CA, IRF1, FASLG

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	15	SLC22A18, KRAS, EGFR, CASP8, CYP2A6, IRF1, PARK2, DLEC1, RASSF1, BRAF, ERBB2, PIK3CA, ERCC6, MAP3K8, FASLG
cell part (GO:0044464)	0.11	15	SLC22A18, KRAS, ERCC6, CASP8, CYP2A6, MAP3K8, PARK2, DLEC1, RASSF1, BRAF, ERBB2, PIK3CA, EGFR, IRF1, FASLG
membrane-bounded organelle (GO:0043227)	0.47	13	CYP2A6, KRAS, ERCC6, CASP8, IRF1, MXRA5, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, BRAF, FASLG
organelle (GO:0043226)	0.4	13	CYP2A6, KRAS, ERCC6, CASP8, IRF1, MXRA5, PARK2, PPP2R1B, ERBB2, RASSF1, EGFR, BRAF, FASLG
cytoplasm (GO:0005737)	1.01	11	SLC22A18, CASP8, IRF1, PARK2, DLEC1, RASSF1, BRAF, ERBB2, KRAS, EGFR, MAP3K8
cytoplasmic part (GO:0044444)	0.82	11	CYP2A6, CASP8, IRF1, PARK2, PIK3CA, BRAF, ERBB2, KRAS, EGFR, MAP3K8, FASLG
intracellular organelle (GO:0043229)	0.51	11	CYP2A6, ERCC6, CASP8, IRF1, PARK2, RASSF1, ERBB2, KRAS, EGFR, BRAF, FASLG
membrane (GO:0016020)	0.68	11	SLC22A18, KRAS, CASP8, BRAF, CYP2A6, RASSF1, ERBB2, PPP2R1B, EGFR, PIK3CA, FASLG
intracellular membrane-bounded organelle (GO:0043231)	0.6	11	CYP2A6, ERCC6, CASP8, IRF1, PARK2, RASSF1, ERBB2, KRAS, EGFR, BRAF, FASLG
intracellular organelle part (GO:0044446)	0.81	9	SLC22A18, ERCC6, CASP8, IRF1, CYP2A6, RASSF1, ERBB2, EGFR, FASLG
membrane part (GO:0044425)	0.95	9	SLC22A18, KRAS, CASP8, CYP2A6, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
organelle part (GO:0044422)	0.79	9	SLC22A18, ERCC6, CASP8, IRF1, CYP2A6, RASSF1, ERBB2, EGFR, FASLG
nucleus (GO:0005634)	1.07	8	EGFR, IRF1, PARK2, RASSF1, ERBB2, ERCC6, BRAF, FASLG
plasma membrane (GO:0005886)	1.39	8	SLC22A18, KRAS, BRAF, RASSF1, ERBB2, PIK3CA, EGFR, FASLG
cytosol (GO:0005829)	1.68	7	CASP8, MAP3K8, PARK2, PIK3CA, BRAF, KRAS, IRF1
macromolecular complex (GO:0032991)	1.35	7	ERCC6, CASP8, IRF1, PARK2, PIK3CA, ERBB2, EGFR
protein complex (GO:0043234)	1.51	6	EGFR, CASP8, PARK2, PIK3CA, ERBB2, ERCC6
plasma membrane part (GO:0044459)	1.95	6	SLC22A18, CASP8, KRAS, ERBB2, EGFR, FASLG
membrane raft (GO:0045121)	4.18	5	KRAS, EGFR, CASP8, PPP2R1B, FASLG
vesicle (GO:0031982)	1.64	5	ERBB2, MXRA5, EGFR, PPP2R1B, FASLG
integral component of membrane (GO:0016021)	1.14	5	CYP2A6, ERBB2, SLC22A18, FASLG, EGFR
membrane region (GO:0098589)	3.95	5	KRAS, FASLG, CASP8, PPP2R1B, EGFR
nuclear part (GO:0044428)	1.55	5	ERCC6, IRF1, SLC22A18, EGFR, CASP8
membrane microdomain (GO:0098857)	4.17	5	KRAS, FASLG, CASP8, PPP2R1B, EGFR
intrinsic component of membrane (GO:0031224)	1.13	5	CYP2A6, ERBB2, SLC22A18, FASLG, EGFR
plasma membrane region (GO:0098590)	2.97	4	ERBB2, SLC22A18, EGFR, FASLG
intracellular (GO:0005622)	2.37	4	EGFR, KRAS, PIK3CA, RASSF1
organelle membrane (GO:0031090)	1.97	4	ERBB2, CASP8, CYP2A6, EGFR
mitochondrion (GO:0005739)	2.42	4	BRAF, PARK2, CASP8, KRAS
membrane-bounded vesicle (GO:0031988)	1.71	4	PPP2R1B, MXRA5, EGFR, FASLG
perinuclear region of cytoplasm (GO:0048471)	3.35	4	ERBB2, PARK2, FASLG, EGFR
cell projection (GO:0042995)	2.47	4	BRAF, PARK2, CASP8, PIK3CA
extracellular region part (GO:0044421)	1.57	4	PPP2R1B, MXRA5, EGFR, FASLG
extracellular organelle (GO:0043230)	1.89	3	MXRA5, PPP2R1B, FASLG
endoplasmic reticulum (GO:0005783)	2.56	3	CYP2A6, PARK2, EGFR
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	3	ERCC6, CASP8, RASSF1
membrane protein complex (GO:0098796)	2.84	3	CASP8, EGFR, PIK3CA
cytoplasmic vesicle (GO:0031410)	2.87	3	ERBB2, EGFR, FASLG
bounding membrane of organelle (GO:0098588)	2.39	3	ERBB2, CASP8, EGFR
extracellular exosome (GO:0070062)	1.89	3	FASLG, PPP2R1B, MXRA5
nucleoplasm (GO:0005654)	1.89	3	IRF1, CASP8, ERCC6
neuron part (GO:0097458)	2.64	3	BRAF, PARK2, CASP8
intracellular vesicle (GO:0097708)	2.86	3	ERBB2, EGFR, FASLG
non-membrane-bounded organelle (GO:0043228)	1.76	3	ERCC6, CASP8, RASSF1
vacuolar part (GO:0044437)	3.26	3	ERBB2, FASLG, EGFR
cytoskeletal part (GO:0044430)	2.49	3	CYP2A6, CASP8, RASSF1
neuron projection (GO:0043005)	3.12	3	BRAF, PARK2, CASP8
extracellular region (GO:0005576)	2.18	3	EGFR, MXRA5, FASLG
extracellular vesicle (GO:1903561)	1.89	3	FASLG, PPP2R1B, MXRA5
whole membrane (GO:0098805)	2.85	3	ERBB2, CASP8, EGFR
catalytic complex (GO:1902494)	2.9	3	PARK2, CASP8, PIK3CA
supramolecular fiber (GO:0099512)	3.31	2	CYP2A6, RASSF1
polymeric cytoskeletal fiber (GO:0099513)	3.31	2	CYP2A6, RASSF1
membrane-enclosed lumen (GO:0031974)	3.05	2	EGFR, FASLG
endoplasmic reticulum membrane (GO:0005789)	2.95	2	CYP2A6, EGFR
cell-substrate adherens junction (GO:0005924)	3.83	2	KRAS, EGFR
focal adhesion (GO:0005925)	3.83	2	KRAS, EGFR
microtubule (GO:0005874)	3.81	2	CYP2A6, RASSF1
cell junction (GO:0030054)	2.75	2	KRAS, EGFR
cell-substrate junction (GO:0030055)	3.82	2	KRAS, EGFR
cytoskeleton (GO:0005856)	2.55	2	CASP8, RASSF1
vesicle lumen (GO:0031983)	5.17	2	EGFR, FASLG
extracellular space (GO:0005615)	2.63	2	EGFR, FASLG
intracellular organelle lumen (GO:0070013)	3.05	2	EGFR, FASLG
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	FASLG, EGFR
vacuolar lumen (GO:0005775)	5.06	2	FASLG, EGFR
vacuolar membrane (GO:0005774)	3.45	2	ERBB2, EGFR
cytoplasmic vesicle part (GO:0044433)	3.41	2	FASLG, EGFR
endoplasmic reticulum part (GO:0044432)	2.73	2	CYP2A6, EGFR
endosome membrane (GO:0010008)	3.83	2	ERBB2, EGFR
Golgi apparatus (GO:0005794)	2.7	2	PARK2, EGFR
apical plasma membrane (GO:0016324)	4.13	2	ERBB2, SLC22A18
cell surface (GO:0009986)	3.44	2	EGFR, FASLG
anchoring junction (GO:0070161)	3.61	2	KRAS, EGFR
cell body (GO:0044297)	3.74	2	BRAF, CASP8
basolateral plasma membrane (GO:0016323)	4.56	2	ERBB2, EGFR
adherens junction (GO:0005912)	3.66	2	KRAS, EGFR
transferase complex (GO:1990234)	3.32	2	PARK2, PIK3CA
receptor complex (GO:0043235)	4.01	2	ERBB2, EGFR
microtubule organizing center (GO:0005815)	3.42	2	CASP8, RASSF1
organelle lumen (GO:0043233)	3.05	2	EGFR, FASLG
plasma membrane protein complex (GO:0098797)	3.55	2	CASP8, EGFR
vacuole (GO:0005773)	2.92	2	EGFR, FASLG
endosomal part (GO:0044440)	3.73	2	ERBB2, EGFR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
plasma membrane region (GO:0098590)	-	2.97	0.032	SLC22A18, CASP8, PPP2R1B, ERBB2, PIK3CA, EGFR, FASLG
endocytic vesicle (GO:0030139)	NEW	5.04	0.026	FASLG, KRAS, EGFR, PIK3CA
side of membrane (GO:0098552)	NEW	4.22	0.001	CASP8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
cell-substrate adherens junction (GO:0005924)	-	3.83	0.025	CASP8, BRAF, KRAS, ERBB2, RASSF1, EGFR
focal adhesion (GO:0005925)	-	3.83	0.021	CASP8, BRAF, KRAS, ERBB2, RASSF1, EGFR
microtubule (GO:0005874)	-	3.81	0.017	CYP2A6, KRAS, ERBB2, RASSF1, EGFR, FASLG
cell junction (GO:0030054)	-	2.75	0.009	KRAS, CASP8, IRF1, PARK2, RASSF1, ERBB2, PIK3CA, EGFR, BRAF, FASLG
cell-substrate junction (GO:0030055)	-	3.82	0.026	CASP8, BRAF, KRAS, ERBB2, RASSF1, EGFR
clathrin-coated vesicle membrane (GO:0030665)	NEW	5.6	0.001	ERBB2, CASP8, IRF1, FASLG
coated vesicle membrane (GO:0030662)	NEW	5.0	0.013	ERBB2, CASP8, IRF1, FASLG
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.04	CASP8, MAP3K8, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
microtubule organizing center (GO:0005815)	-	3.42	0.042	CASP8, MAP3K8, PPP2R1B, ERBB2, RASSF1, EGFR, IRF1
Golgi apparatus part (GO:0044431)	NEW	3.0	0.001	KRAS, CASP8, MAP3K8, PARK2, PPP2R1B, ERBB2, PIK3CA, EGFR, IRF1, FASLG
cytoskeletal part (GO:0044430)	-	2.49	0.0	CYP2A6, KRAS, CASP8, IRF1, PARK2, PPP2R1B, BRAF, ERBB2, RASSF1, EGFR, PIK3CA, MAP3K8, FASLG
neuron projection (GO:0043005)	-	3.12	0.003	KRAS, CASP8, BRAF, PARK2, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
catalytic complex (GO:1902494)	-	2.9	0.003	ERCC6, CASP8, BRAF, PARK2, PIK3CA, ERBB2, KRAS, EGFR, FASLG
apical plasma membrane (GO:0016324)	-	4.13	0.018	SLC22A18, CASP8, PIK3CA, ERBB2, EGFR, FASLG
membrane region (GO:0098589)	-	3.95	0.007	SLC22A18, KRAS, CASP8, MAP3K8, CYP2A6, PPP2R1B, ERBB2, PIK3CA, EGFR, BRAF, FASLG
cell body (GO:0044297)	-	3.74	0.006	CASP8, BRAF, PARK2, KRAS, ERBB2, EGFR, FASLG
membrane raft (GO:0045121)	-	4.18	0.0	KRAS, CASP8, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
Golgi membrane (GO:0000139)	NEW	3.28	0.035	KRAS, IRF1, PIK3CA, ERBB2, PPP2R1B, EGFR, FASLG
cytosolic part (GO:0044445)	NEW	4.34	0.042	IRF1, KRAS, CASP8, PIK3CA