Disease table of TOBACCO ADDICTION, SUSCEPTIBILITY TO OMIM ID: 188890

Gene-disease associations table

GeneAssociated with TOBACCO ADDICTION, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CHRNA4OMIMHGNC link20q13.332PS600513, 188890
SLC6A3OMIMHGNC link5p15.332613135, 188890
GABBR2ClinVar, OMIMHGNC link9q22.331188890
CYP2A6OMIMHGNC link19q13.23188890, 122700, 211980

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SLC6A3YES1NR4A20
CYP2A6YES1NFYA0
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Neuroactive ligand-receptor interactionhsa040804.582CHRNA4, GABBR2

NET-GE enrichment

Term New enriched termICP valueGenes
Substance dependenceNEW4.770.007CHRNA4, GABBR2, SLC6A3
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Neuronal SystemR-HSA-1123164.823CHRNA4, GABBR2, SLC6A3
Transmission across Chemical SynapsesR-HSA-1123155.283CHRNA4, GABBR2, SLC6A3
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.852CHRNA4, GABBR2

NET-GE enrichment

Term New enriched termICP valueGenes
Neuronal System (R-HSA-112316) -4.820.006CHRNA4, GABBR2, SLC6A3
Transmission across Chemical Synapses (R-HSA-112315) -5.280.015CHRNA4, GABBR2, SLC6A3
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184CYP2A6, CHRNA4, GABBR2, SLC6A3
cation binding (GO:0043169) 1.43CHRNA4, CYP2A6, SLC6A3
protein binding (GO:0005515) 0.463GABBR2, CYP2A6, SLC6A3
ion binding (GO:0043167) 1.363CHRNA4, CYP2A6, SLC6A3
substrate-specific transmembrane transporter activity (GO:0022891) 2.92CHRNA4, SLC6A3
substrate-specific transporter activity (GO:0022892) 2.722CHRNA4, SLC6A3
signaling receptor activity (GO:0038023) 2.492CHRNA4, GABBR2
transporter activity (GO:0005215) 2.572CHRNA4, SLC6A3
cation transmembrane transporter activity (GO:0008324) 3.322CHRNA4, SLC6A3
transmembrane signaling receptor activity (GO:0004888) 2.572CHRNA4, GABBR2
enzyme binding (GO:0019899) 2.272CYP2A6, SLC6A3
ion transmembrane transporter activity (GO:0015075) 3.042CHRNA4, SLC6A3
molecular transducer activity (GO:0060089) 2.322CHRNA4, GABBR2
transmembrane transporter activity (GO:0022857) 2.822CHRNA4, SLC6A3
receptor activity (GO:0004872) 2.322CHRNA4, GABBR2
signal transducer activity (GO:0004871) 2.282CHRNA4, GABBR2
organic cyclic compound binding (GO:0097159) 1.052CYP2A6, SLC6A3
metal ion binding (GO:0046872) 1.412CYP2A6, SLC6A3
transmembrane receptor activity (GO:0099600) 2.532CHRNA4, GABBR2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.264CYP2A6, CHRNA4, GABBR2, SLC6A3
single-organism process (GO:0044699) 0.484CYP2A6, CHRNA4, GABBR2, SLC6A3
cellular aromatic compound metabolic process (GO:0006725) 1.33CHRNA4, CYP2A6, SLC6A3
cellular metabolic process (GO:0044237) 0.693CHRNA4, CYP2A6, SLC6A3
regulation of cellular process (GO:0050794) 0.53CHRNA4, GABBR2, SLC6A3
organic substance metabolic process (GO:0071704) 0.633CHRNA4, CYP2A6, SLC6A3
biological regulation (GO:0065007) 0.393CHRNA4, GABBR2, SLC6A3
metabolic process (GO:0008152) 0.583CHRNA4, CYP2A6, SLC6A3
single-organism cellular process (GO:0044763) 0.653CYP2A6, CHRNA4, GABBR2
regulation of biological process (GO:0050789) 0.453CHRNA4, GABBR2, SLC6A3
organic cyclic compound metabolic process (GO:1901360) 1.263CHRNA4, CYP2A6, SLC6A3
regulation of primary metabolic process (GO:0080090) 1.082GABBR2, SLC6A3
regulation of metabolic process (GO:0019222) 1.022GABBR2, SLC6A3
regulation of cellular metabolic process (GO:0031323) 1.072GABBR2, SLC6A3
behavior (GO:0007610) 3.472CHRNA4, SLC6A3
cellular catabolic process (GO:0044248) 2.622CYP2A6, SLC6A3
nitrogen compound metabolic process (GO:0006807) 1.132CHRNA4, SLC6A3
signaling (GO:0023052) 3.252CHRNA4, GABBR2
signal transduction (GO:0007165) 1.282CHRNA4, GABBR2
response to alkaloid (GO:0043279) 4.832CHRNA4, SLC6A3
localization (GO:0051179) 1.42CHRNA4, SLC6A3
response to organic cyclic compound (GO:0014070) 3.072CHRNA4, SLC6A3
organic cyclic compound catabolic process (GO:1901361) 3.732CYP2A6, SLC6A3
response to endogenous stimulus (GO:0009719) 2.792CHRNA4, SLC6A3
organic substance catabolic process (GO:1901575) 2.452CYP2A6, SLC6A3
response to nitrogen compound (GO:1901698) 3.122CHRNA4, SLC6A3
heterocycle metabolic process (GO:0046483) 1.312CHRNA4, CYP2A6
transmembrane transport (GO:0055085) 2.722CHRNA4, SLC6A3
neurological system process (GO:0050877) 2.642CHRNA4, SLC6A3
negative regulation of biological process (GO:0048519) 1.332GABBR2, SLC6A3
regulation of biological quality (GO:0065008) 1.682CHRNA4, SLC6A3
locomotory behavior (GO:0007626) 4.532CHRNA4, SLC6A3
multicellular organismal process (GO:0032501) 1.452CHRNA4, SLC6A3
primary metabolic process (GO:0044238) 0.692CHRNA4, CYP2A6
cation transport (GO:0006812) 3.112CHRNA4, SLC6A3
ion transport (GO:0006811) 2.662CHRNA4, SLC6A3
transport (GO:0006810) 1.512CHRNA4, SLC6A3
sensory perception (GO:0007600) 2.932CHRNA4, SLC6A3
ion transmembrane transport (GO:0034220) 3.082CHRNA4, SLC6A3
response to chemical (GO:0042221) 1.982CHRNA4, SLC6A3
regulation of nitrogen compound metabolic process (GO:0051171) 1.362GABBR2, SLC6A3
chemical synaptic transmission (GO:0007268) 3.982CHRNA4, GABBR2
cell-cell signaling (GO:0007267) 3.352CHRNA4, GABBR2
cell communication (GO:0007154) 3.042CHRNA4, GABBR2
establishment of localization (GO:0051234) 1.482CHRNA4, SLC6A3
catabolic process (GO:0009056) 2.382CYP2A6, SLC6A3
response to organic substance (GO:0010033) 2.22CHRNA4, SLC6A3
system process (GO:0003008) 2.32CHRNA4, SLC6A3
single organism signaling (GO:0044700) 3.252CHRNA4, GABBR2
single-multicellular organism process (GO:0044707) 1.782CHRNA4, SLC6A3
response to stimulus (GO:0050896) 1.222CHRNA4, SLC6A3
response to nicotine (GO:0035094) 5.782CHRNA4, SLC6A3
anterograde trans-synaptic signaling (GO:0098916) 3.982CHRNA4, GABBR2
aromatic compound catabolic process (GO:0019439) 3.792CYP2A6, SLC6A3
cation transmembrane transport (GO:0098655) 3.432CHRNA4, SLC6A3
response to organonitrogen compound (GO:0010243) 3.22CHRNA4, SLC6A3
synaptic signaling (GO:0099536) 3.982CHRNA4, GABBR2
trans-synaptic signaling (GO:0099537) 3.982CHRNA4, GABBR2

NET-GE enrichment

Term New enriched termICP valueGenes
response to nicotine (GO:0035094) -5.780.006CHRNA4, SLC6A3
synaptic transmission (GO:0007268) -3.980.012CHRNA4, GABBR2, SLC6A3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane part (GO:0044425) 0.954CYP2A6, CHRNA4, GABBR2, SLC6A3
integral component of membrane (GO:0016021) 1.144CYP2A6, CHRNA4, GABBR2, SLC6A3
membrane (GO:0016020) 0.684CYP2A6, CHRNA4, GABBR2, SLC6A3
cell part (GO:0044464) 0.114CYP2A6, CHRNA4, GABBR2, SLC6A3
intrinsic component of membrane (GO:0031224) 1.134CYP2A6, CHRNA4, GABBR2, SLC6A3
protein complex (GO:0043234) 1.513CHRNA4, GABBR2, SLC6A3
macromolecular complex (GO:0032991) 1.353CHRNA4, GABBR2, SLC6A3
membrane protein complex (GO:0098796) 2.843CHRNA4, GABBR2, SLC6A3
plasma membrane protein complex (GO:0098797) 3.553CHRNA4, GABBR2, SLC6A3
neuron part (GO:0097458) 2.643CHRNA4, GABBR2, SLC6A3
synapse part (GO:0044456) 3.423CHRNA4, GABBR2, SLC6A3
neuron projection (GO:0043005) 3.123CHRNA4, GABBR2, SLC6A3
plasma membrane (GO:0005886) 1.393CHRNA4, GABBR2, SLC6A3
intracellular part (GO:0044424) 0.283GABBR2, CYP2A6, SLC6A3
cell projection (GO:0042995) 2.473CHRNA4, GABBR2, SLC6A3
plasma membrane part (GO:0044459) 1.953CHRNA4, GABBR2, SLC6A3
cytoplasm (GO:0005737) 1.012GABBR2, SLC6A3
plasma membrane region (GO:0098590) 2.972CHRNA4, GABBR2
receptor complex (GO:0043235) 4.012CHRNA4, GABBR2
neuronal cell body (GO:0043025) 3.92CHRNA4, SLC6A3
cell body (GO:0044297) 3.742CHRNA4, SLC6A3
plasma membrane receptor complex (GO:0098802) 4.632CHRNA4, GABBR2
postsynaptic membrane (GO:0045211) 4.472CHRNA4, GABBR2
synapse (GO:0045202) 3.582CHRNA4, GABBR2
integral component of plasma membrane (GO:0005887) 2.572GABBR2, SLC6A3
synaptic membrane (GO:0097060) 4.222CHRNA4, GABBR2
intrinsic component of plasma membrane (GO:0031226) 2.532GABBR2, SLC6A3
cell junction (GO:0030054) 2.752CHRNA4, GABBR2

NET-GE enrichment

Term New enriched termICP valueGenes
synaptic membrane (GO:0097060) -4.220.039CHRNA4, GABBR2
receptor complex (GO:0043235) -4.010.049CHRNA4, GABBR2
postsynaptic membrane (GO:0045211) -4.470.027CHRNA4, GABBR2
neuron part (GO:0097458) -2.640.019CHRNA4, GABBR2, SLC6A3
neuron projection (GO:0043005) -3.120.005CHRNA4, GABBR2, SLC6A3
cell projection (GO:0042995) -2.470.033CHRNA4, GABBR2, SLC6A3
neuronal cell body (GO:0043025) -3.90.049CHRNA4, SLC6A3