Disease table of GLAUCOMA, PRIMARY OPEN ANGLE OMIM ID: 137760

Gene-disease associations table

GeneAssociated with GLAUCOMA, PRIMARY OPEN ANGLE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
OPTNOMIM, HUMSAVARHGNC link10p133PS105400, 606657, 137760
CYP1B1ClinVar, HUMSAVARHGNC link2p22.24137760, 137750, 231300, 604229
LTBP2ClinVarHGNC link14q24.37154700, 251750, 129600, PS277600, 177650, 613086, 137760

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
OPTNYES2NFKB1, RELA0
CYP1B1YES4SP1, AHR, ARNT, ESR10
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
OPTNCYP1B1No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183LTBP2, CYP1B1, OPTN
cation binding (GO:0043169) 1.42LTBP2, CYP1B1
metal ion binding (GO:0046872) 1.412LTBP2, CYP1B1
protein binding (GO:0005515) 0.462LTBP2, OPTN
ion binding (GO:0043167) 1.362LTBP2, CYP1B1
GO - biological process annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
single-organism process (GO:0044699) 0.483LTBP2, CYP1B1, OPTN
cellular process (GO:0009987) 0.263LTBP2, CYP1B1, OPTN
cellular component organization (GO:0016043) 1.243LTBP2, CYP1B1, OPTN
regulation of cellular process (GO:0050794) 0.53LTBP2, CYP1B1, OPTN
biological regulation (GO:0065007) 0.393LTBP2, CYP1B1, OPTN
signal transduction (GO:0007165) 1.283LTBP2, CYP1B1, OPTN
single-organism cellular process (GO:0044763) 0.653LTBP2, CYP1B1, OPTN
regulation of biological process (GO:0050789) 0.453LTBP2, CYP1B1, OPTN
cellular component organization or biogenesis (GO:0071840) 1.223LTBP2, CYP1B1, OPTN
protein localization (GO:0008104) 2.362LTBP2, OPTN
regulation of metabolic process (GO:0019222) 1.022CYP1B1, OPTN
regulation of response to stimulus (GO:0048583) 1.542CYP1B1, OPTN
regulation of signaling (GO:0023051) 1.722CYP1B1, OPTN
regulation of cell communication (GO:0010646) 1.732CYP1B1, OPTN
regulation of intracellular signal transduction (GO:1902531) 2.312CYP1B1, OPTN
regulation of signal transduction (GO:0009966) 1.842CYP1B1, OPTN
intracellular protein transport (GO:0006886) 3.22LTBP2, OPTN
organic substance transport (GO:0071702) 2.152LTBP2, OPTN
negative regulation of biological process (GO:0048519) 1.332CYP1B1, OPTN
macromolecule localization (GO:0033036) 2.342LTBP2, OPTN
extracellular structure organization (GO:0043062) 4.02LTBP2, CYP1B1
regulation of macromolecule metabolic process (GO:0060255) 1.082CYP1B1, OPTN
regulation of cellular metabolic process (GO:0031323) 1.072CYP1B1, OPTN
transport (GO:0006810) 1.512LTBP2, OPTN
protein targeting (GO:0006605) 4.082LTBP2, OPTN
establishment of protein localization (GO:0045184) 2.532LTBP2, OPTN
single-organism transport (GO:0044765) 2.182LTBP2, OPTN
establishment of localization in cell (GO:0051649) 2.472LTBP2, OPTN
establishment of localization (GO:0051234) 1.482LTBP2, OPTN
localization (GO:0051179) 1.42LTBP2, OPTN
single-organism localization (GO:1902578) 2.092LTBP2, OPTN
cellular localization (GO:0051641) 2.322LTBP2, OPTN
intracellular transport (GO:0046907) 2.672LTBP2, OPTN
response to stimulus (GO:0050896) 1.222CYP1B1, OPTN
response to stress (GO:0006950) 1.82CYP1B1, OPTN
extracellular matrix organization (GO:0030198) 4.012LTBP2, CYP1B1
protein transport (GO:0015031) 2.622LTBP2, OPTN
negative regulation of cellular process (GO:0048523) 1.412CYP1B1, OPTN
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.113LTBP2, CYP1B1, OPTN
membrane-bounded organelle (GO:0043227) 0.473LTBP2, CYP1B1, OPTN
organelle (GO:0043226) 0.43LTBP2, CYP1B1, OPTN
vesicle (GO:0031982) 1.642LTBP2, OPTN
membrane (GO:0016020) 0.682CYP1B1, OPTN
cytoplasmic part (GO:0044444) 0.822CYP1B1, OPTN
intracellular membrane-bounded organelle (GO:0043231) 0.62CYP1B1, OPTN
intracellular organelle part (GO:0044446) 0.812CYP1B1, OPTN
intracellular organelle (GO:0043229) 0.512CYP1B1, OPTN
intracellular part (GO:0044424) 0.282CYP1B1, OPTN
membrane-bounded vesicle (GO:0031988) 1.712LTBP2, OPTN
organelle part (GO:0044422) 0.792CYP1B1, OPTN
organelle membrane (GO:0031090) 1.972CYP1B1, OPTN