Disease table of GLAUCOMA, NORMAL TENSION, SUSCEPTIBILITY TO OMIM ID: 606657

Gene-disease associations table

GeneAssociated with GLAUCOMA, NORMAL TENSION, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
OPTNClinVar, OMIMHGNC link10p133PS105400, 606657, 137760
OPA1ClinVar, OMIMHGNC link3q296PS256300, 210000, PS165500, PS603041, 125250, 606657

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
OPTNYES2NFKB1, RELA0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
OPTNOPA1No1PARK2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182OPA1, OPTN
protein binding (GO:0005515) 0.462OPA1, OPTN
GO - biological process annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
negative regulation of response to stimulus (GO:0048585) 2.522OPA1, OPTN
regulation of response to stimulus (GO:0048583) 1.542OPA1, OPTN
negative regulation of signaling (GO:0023057) 2.652OPA1, OPTN
negative regulation of cell communication (GO:0010648) 2.662OPA1, OPTN
regulation of signaling (GO:0023051) 1.722OPA1, OPTN
cell death (GO:0008219) 3.052OPA1, OPTN
regulation of cell communication (GO:0010646) 1.732OPA1, OPTN
regulation of biological process (GO:0050789) 0.452OPA1, OPTN
cellular component organization or biogenesis (GO:0071840) 1.222OPA1, OPTN
regulation of intracellular signal transduction (GO:1902531) 2.312OPA1, OPTN
negative regulation of signal transduction (GO:0009968) 2.752OPA1, OPTN
regulation of signal transduction (GO:0009966) 1.842OPA1, OPTN
cellular component organization (GO:0016043) 1.242OPA1, OPTN
biological regulation (GO:0065007) 0.392OPA1, OPTN
single-organism process (GO:0044699) 0.482OPA1, OPTN
negative regulation of biological process (GO:0048519) 1.332OPA1, OPTN
cellular process (GO:0009987) 0.262OPA1, OPTN
transport (GO:0006810) 1.512OPA1, OPTN
regulation of cellular process (GO:0050794) 0.52OPA1, OPTN
single-organism transport (GO:0044765) 2.182OPA1, OPTN
single-organism membrane organization (GO:0044802) 3.192OPA1, OPTN
establishment of localization in cell (GO:0051649) 2.472OPA1, OPTN
negative regulation of intracellular signal transduction (GO:1902532) 3.632OPA1, OPTN
establishment of localization (GO:0051234) 1.482OPA1, OPTN
localization (GO:0051179) 1.42OPA1, OPTN
single-organism localization (GO:1902578) 2.092OPA1, OPTN
cellular localization (GO:0051641) 2.322OPA1, OPTN
organelle organization (GO:0006996) 2.022OPA1, OPTN
intracellular transport (GO:0046907) 2.672OPA1, OPTN
membrane organization (GO:0061024) 3.042OPA1, OPTN
response to stimulus (GO:0050896) 1.222OPA1, OPTN
response to stress (GO:0006950) 1.82OPA1, OPTN
single-organism cellular process (GO:0044763) 0.652OPA1, OPTN
single-organism cellular localization (GO:1902580) 3.162OPA1, OPTN
negative regulation of cellular process (GO:0048523) 1.412OPA1, OPTN
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.012OPA1, OPTN
intracellular organelle part (GO:0044446) 0.812OPA1, OPTN
organelle membrane (GO:0031090) 1.972OPA1, OPTN
bounding membrane of organelle (GO:0098588) 2.392OPA1, OPTN
membrane (GO:0016020) 0.682OPA1, OPTN
cell part (GO:0044464) 0.112OPA1, OPTN
cytoplasmic part (GO:0044444) 0.822OPA1, OPTN
nucleoplasm (GO:0005654) 1.892OPA1, OPTN
intracellular organelle (GO:0043229) 0.512OPA1, OPTN
nuclear part (GO:0044428) 1.552OPA1, OPTN
intracellular part (GO:0044424) 0.282OPA1, OPTN
membrane-bounded organelle (GO:0043227) 0.472OPA1, OPTN
organelle (GO:0043226) 0.42OPA1, OPTN
organelle part (GO:0044422) 0.792OPA1, OPTN
intracellular membrane-bounded organelle (GO:0043231) 0.62OPA1, OPTN