Disease table of PETERS ANOMALY OMIM ID: 604229

Gene-disease associations table

GeneAssociated with PETERS ANOMALY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PITX2OMIMHGNC link4q254604229, 180550, 180500, 137600
PAX6OMIM, HUMSAVARHGNC link11p138148190, 120200, 106210, 206700, 604229, 120430, PS136520, 165550
CYP1B1OMIMHGNC link2p22.24137760, 137750, 231300, 604229
FOXC1HUMSAVARHGNC link6p25.34604229, 602482, 601631, 308500

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
PITX2YES9LEF1, HESX1, ABCB1, SLC13A3, WNT2, LHX6, PRL, PLOD1, WNT5A0
PAX6YES12FABP7, PROX1, GCK, ITGB1, SIX3, MET, PCSK1, PDHX, ITGA5, MMP2, KRT12, GCG0
FOXC1YES2FGF19, FOXO10
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12PAX6, CYP1B1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PAX6YES7SP1, CTCF, OTX2, SOX2, TFCP2, FOXA2, SIRT10
CYP1B1YES4SP1, AHR, ARNT, ESR10
FOXC1YES3BRCA1, GATA3, EZH20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PITX2PAX6No1SMAD3
PITX2FOXC1No1FOXC2
PAX6FOXC1No1SOX2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PITX2PAX6No-9SIX3, SALL1, EP300, POU3F4, PLP1, SMAD3, KAT5, NOG, SHH
PITX2FOXC1Yesexpression, binding1SHH
PAX6CYP1B1No-1MMP2
PAX6FOXC1No-1SHH

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic cyclic compound binding (GO:0097159) 1.054PAX6, CYP1B1, PITX2, FOXC1
binding (GO:0005488) 0.184PAX6, CYP1B1, PITX2, FOXC1
heterocyclic compound binding (GO:1901363) 1.064PAX6, CYP1B1, PITX2, FOXC1
sequence-specific DNA binding (GO:0043565) 2.793PAX6, FOXC1, PITX2
sequence-specific double-stranded DNA binding (GO:1990837) 3.23PAX6, FOXC1, PITX2
protein binding (GO:0005515) 0.463PAX6, FOXC1, PITX2
transcription regulatory region DNA binding (GO:0044212) 3.033PAX6, FOXC1, PITX2
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653PAX6, FOXC1, PITX2
regulatory region nucleic acid binding (GO:0001067) 3.033PAX6, FOXC1, PITX2
transcription factor binding (GO:0008134) 3.463PAX6, FOXC1, PITX2
regulatory region DNA binding (GO:0000975) 3.033PAX6, FOXC1, PITX2
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.363PAX6, FOXC1, PITX2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.983PAX6, FOXC1, PITX2
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.243PAX6, FOXC1, PITX2
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.373PAX6, FOXC1, PITX2
nucleic acid binding (GO:0003676) 1.443PAX6, FOXC1, PITX2
DNA binding (GO:0003677) 1.923PAX6, FOXC1, PITX2
double-stranded DNA binding (GO:0003690) 3.093PAX6, FOXC1, PITX2
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.293PAX6, FOXC1, PITX2
nucleic acid binding transcription factor activity (GO:0001071) 2.653PAX6, FOXC1, PITX2
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001227) 4.612PAX6, PITX2
core promoter proximal region DNA binding (GO:0001159) 3.822PAX6, PITX2
catalytic activity (GO:0003824) 1.052PAX6, CYP1B1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077) 4.312PAX6, PITX2
macromolecular complex binding (GO:0044877) 2.612PAX6, PITX2
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832PAX6, PITX2
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3.882PAX6, PITX2
chromatin binding (GO:0003682) 3.642PAX6, PITX2
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942PAX6, PITX2

NET-GE enrichment

Term New enriched termICP valueGenes
transcription regulatory region DNA binding (GO:0044212) -3.030.006PAX6, FOXC1, PITX2
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription (GO:0001191) NEW5.280.019PAX6, PITX2
DNA binding, bending (GO:0008301) NEW6.740.006FOXC1, PITX2
sequence-specific DNA binding (GO:0043565) -2.790.025PAX6, FOXC1, PITX2
RNA polymerase II regulatory region DNA binding (GO:0001012) -3.360.001PAX6, FOXC1, PITX2
transcription factor binding (GO:0008134) -3.460.005PAX6, FOXC1, PITX2
regulatory region nucleic acid binding (GO:0001067) -3.030.007PAX6, FOXC1, PITX2
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) -3.980.0PAX6, FOXC1, PITX2
core promoter proximal region DNA binding (GO:0001159) -3.820.039PAX6, PITX2
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) NEW5.230.002PAX6, FOXC1, PITX2
chromatin DNA binding (GO:0031490) NEW5.370.036PAX6, PITX2
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077) -4.310.034PAX6, PITX2
transcription regulatory region sequence-specific DNA binding (GO:0000976) -3.240.002PAX6, FOXC1, PITX2
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) -3.370.001PAX6, FOXC1, PITX2
regulatory region DNA binding (GO:0000975) -3.030.007PAX6, FOXC1, PITX2
core promoter proximal region sequence-specific DNA binding (GO:0000987) -3.830.038PAX6, PITX2
G-protein coupled receptor binding (GO:0001664) NEW4.180.03PAX6, CYP1B1, PITX2
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) -3.880.034PAX6, PITX2
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.003PAX6, FOXC1, PITX2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of RNA metabolic process (GO:0051252) 1.524PAX6, CYP1B1, PITX2, FOXC1
regulation of primary metabolic process (GO:0080090) 1.084PAX6, CYP1B1, PITX2, FOXC1
regulation of metabolic process (GO:0019222) 1.024PAX6, CYP1B1, PITX2, FOXC1
regulation of cellular biosynthetic process (GO:0031326) 1.384PAX6, CYP1B1, PITX2, FOXC1
regulation of cellular metabolic process (GO:0031323) 1.074PAX6, CYP1B1, PITX2, FOXC1
movement of cell or subcellular component (GO:0006928) 2.614PAX6, CYP1B1, PITX2, FOXC1
cellular biosynthetic process (GO:0044249) 1.374PAX6, CYP1B1, PITX2, FOXC1
cellular nitrogen compound metabolic process (GO:0034641) 1.224PAX6, CYP1B1, PITX2, FOXC1
nitrogen compound metabolic process (GO:0006807) 1.134PAX6, CYP1B1, PITX2, FOXC1
signal transduction (GO:0007165) 1.284PAX6, CYP1B1, PITX2, FOXC1
anatomical structure morphogenesis (GO:0009653) 2.534PAX6, CYP1B1, PITX2, FOXC1
regulation of biological process (GO:0050789) 0.454PAX6, CYP1B1, PITX2, FOXC1
single-organism process (GO:0044699) 0.484PAX6, CYP1B1, PITX2, FOXC1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464PAX6, CYP1B1, PITX2, FOXC1
organic substance metabolic process (GO:0071704) 0.634PAX6, CYP1B1, PITX2, FOXC1
biological regulation (GO:0065007) 0.394PAX6, CYP1B1, PITX2, FOXC1
organic cyclic compound metabolic process (GO:1901360) 1.264PAX6, CYP1B1, PITX2, FOXC1
positive regulation of biological process (GO:0048518) 1.24PAX6, CYP1B1, PITX2, FOXC1
negative regulation of biological process (GO:0048519) 1.334PAX6, CYP1B1, PITX2, FOXC1
cell migration (GO:0016477) 3.124PAX6, CYP1B1, PITX2, FOXC1
regulation of gene expression (GO:0010468) 1.374PAX6, CYP1B1, PITX2, FOXC1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.014PAX6, CYP1B1, PITX2, FOXC1
developmental process (GO:0032502) 1.364PAX6, CYP1B1, PITX2, FOXC1
multicellular organismal process (GO:0032501) 1.454PAX6, CYP1B1, PITX2, FOXC1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434PAX6, CYP1B1, PITX2, FOXC1
cellular aromatic compound metabolic process (GO:0006725) 1.34PAX6, CYP1B1, PITX2, FOXC1
cellular process (GO:0009987) 0.264PAX6, CYP1B1, PITX2, FOXC1
regulation of biosynthetic process (GO:0009889) 1.374PAX6, CYP1B1, PITX2, FOXC1
regulation of nucleic acid-templated transcription (GO:1903506) 1.554PAX6, CYP1B1, PITX2, FOXC1
regulation of cellular process (GO:0050794) 0.54PAX6, CYP1B1, PITX2, FOXC1
single-organism developmental process (GO:0044767) 1.494PAX6, CYP1B1, PITX2, FOXC1
biosynthetic process (GO:0009058) 1.324PAX6, CYP1B1, PITX2, FOXC1
single-organism cellular process (GO:0044763) 0.654PAX6, CYP1B1, PITX2, FOXC1
regulation of nitrogen compound metabolic process (GO:0051171) 1.364PAX6, CYP1B1, PITX2, FOXC1
metabolic process (GO:0008152) 0.584PAX6, CYP1B1, PITX2, FOXC1
regulation of RNA biosynthetic process (GO:2001141) 1.554PAX6, CYP1B1, PITX2, FOXC1
locomotion (GO:0040011) 2.914PAX6, CYP1B1, PITX2, FOXC1
primary metabolic process (GO:0044238) 0.694PAX6, CYP1B1, PITX2, FOXC1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.594PAX6, CYP1B1, PITX2, FOXC1
cell motility (GO:0048870) 3.024PAX6, CYP1B1, PITX2, FOXC1
regulation of macromolecule metabolic process (GO:0060255) 1.084PAX6, CYP1B1, PITX2, FOXC1
anatomical structure development (GO:0048856) 1.584PAX6, CYP1B1, PITX2, FOXC1
cellular metabolic process (GO:0044237) 0.694PAX6, CYP1B1, PITX2, FOXC1
regulation of transcription, DNA-templated (GO:0006355) 1.564PAX6, CYP1B1, PITX2, FOXC1
regulation of macromolecule biosynthetic process (GO:0010556) 1.434PAX6, CYP1B1, PITX2, FOXC1
system development (GO:0048731) 2.924PAX6, CYP1B1, PITX2, FOXC1
negative regulation of cellular process (GO:0048523) 1.414PAX6, CYP1B1, PITX2, FOXC1
positive regulation of cellular process (GO:0048522) 1.34PAX6, CYP1B1, PITX2, FOXC1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563PAX6, FOXC1, PITX2
positive regulation of metabolic process (GO:0009893) 1.743PAX6, FOXC1, PITX2
positive regulation of biosynthetic process (GO:0009891) 2.293PAX6, FOXC1, PITX2
positive regulation of cellular metabolic process (GO:0031325) 1.813PAX6, FOXC1, PITX2
cell differentiation (GO:0030154) 2.143PAX6, FOXC1, PITX2
cell development (GO:0048468) 3.283PAX6, FOXC1, PITX2
nucleic acid metabolic process (GO:0090304) 1.463PAX6, FOXC1, PITX2
positive regulation of gene expression (GO:0010628) 2.353PAX6, FOXC1, PITX2
cell surface receptor signaling pathway (GO:0007166) 2.093PAX6, FOXC1, PITX2
organic substance biosynthetic process (GO:1901576) 1.343PAX6, FOXC1, PITX2
organic cyclic compound biosynthetic process (GO:1901362) 1.663PAX6, FOXC1, PITX2
multicellular organism development (GO:0007275) 2.543PAX6, FOXC1, PITX2
cellular component organization or biogenesis (GO:0071840) 1.223PAX6, FOXC1, CYP1B1
RNA biosynthetic process (GO:0032774) 1.843PAX6, FOXC1, PITX2
nucleobase-containing compound metabolic process (GO:0006139) 1.353PAX6, FOXC1, PITX2
positive regulation of macromolecule metabolic process (GO:0010604) 1.813PAX6, FOXC1, PITX2
cellular macromolecule metabolic process (GO:0044260) 0.933PAX6, FOXC1, PITX2
cellular developmental process (GO:0048869) 1.823PAX6, FOXC1, PITX2
positive regulation of multicellular organismal process (GO:0051240) 2.493PAX6, FOXC1, CYP1B1
positive regulation of cellular biosynthetic process (GO:0031328) 2.33PAX6, FOXC1, PITX2
cellular component organization (GO:0016043) 1.243PAX6, FOXC1, CYP1B1
animal organ development (GO:0048513) 2.533PAX6, FOXC1, PITX2
blood vessel morphogenesis (GO:0048514) 5.323CYP1B1, PITX2, FOXC1
nucleic acid-templated transcription (GO:0097659) 1.913PAX6, FOXC1, PITX2
transcription from RNA polymerase II promoter (GO:0006366) 3.383PAX6, FOXC1, PITX2
regulation of multicellular organismal development (GO:2000026) 2.313PAX6, FOXC1, CYP1B1
system process (GO:0003008) 2.33PAX6, FOXC1, CYP1B1
heterocycle biosynthetic process (GO:0018130) 1.73PAX6, FOXC1, PITX2
regulation of cell proliferation (GO:0042127) 2.413PAX6, CYP1B1, PITX2
organ morphogenesis (GO:0009887) 3.553PAX6, FOXC1, PITX2
regulation of cell migration (GO:0030334) 3.233PAX6, CYP1B1, PITX2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353PAX6, FOXC1, PITX2
pattern specification process (GO:0007389) 3.793PAX6, FOXC1, PITX2
regulation of developmental process (GO:0050793) 2.13PAX6, FOXC1, CYP1B1
tissue development (GO:0009888) 3.273CYP1B1, PITX2, FOXC1
cellular macromolecule biosynthetic process (GO:0034645) 1.663PAX6, FOXC1, PITX2
regulation of biological quality (GO:0065008) 1.683PAX6, FOXC1, CYP1B1
regulation of locomotion (GO:0040012) 3.123PAX6, CYP1B1, PITX2
eye development (GO:0001654) 5.073PAX6, FOXC1, PITX2
positive regulation of transcription, DNA-templated (GO:0045893) 2.563PAX6, FOXC1, PITX2
regulation of multicellular organismal process (GO:0051239) 1.873PAX6, FOXC1, CYP1B1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293PAX6, FOXC1, PITX2
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723PAX6, FOXC1, PITX2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813PAX6, FOXC1, PITX2
regulation of localization (GO:0032879) 1.943PAX6, CYP1B1, PITX2
heterocycle metabolic process (GO:0046483) 1.313PAX6, FOXC1, PITX2
RNA metabolic process (GO:0016070) 1.593PAX6, FOXC1, PITX2
sensory organ development (GO:0007423) 4.823PAX6, FOXC1, PITX2
regulation of cellular component movement (GO:0051270) 3.083PAX6, CYP1B1, PITX2
brain development (GO:0007420) 4.243PAX6, FOXC1, PITX2
single-multicellular organism process (GO:0044707) 1.783PAX6, FOXC1, PITX2
positive regulation of developmental process (GO:0051094) 2.773PAX6, FOXC1, CYP1B1
response to stimulus (GO:0050896) 1.223PAX6, CYP1B1, PITX2
positive regulation of RNA metabolic process (GO:0051254) 2.513PAX6, FOXC1, PITX2
macromolecule biosynthetic process (GO:0009059) 1.613PAX6, FOXC1, PITX2
macromolecule metabolic process (GO:0043170) 0.833PAX6, FOXC1, PITX2
positive regulation of RNA biosynthetic process (GO:1902680) 2.543PAX6, FOXC1, PITX2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393PAX6, FOXC1, PITX2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243PAX6, FOXC1, PITX2
regulation of cell motility (GO:2000145) 3.163PAX6, CYP1B1, PITX2
transcription, DNA-templated (GO:0006351) 1.913PAX6, FOXC1, PITX2
aromatic compound biosynthetic process (GO:0019438) 1.73PAX6, FOXC1, PITX2
gland development (GO:0048732) 4.153PAX6, FOXC1, PITX2
camera-type eye development (GO:0043010) 5.363PAX6, FOXC1, PITX2
embryonic morphogenesis (GO:0048598) 3.722PAX6, PITX2
embryonic organ morphogenesis (GO:0048562) 4.922PAX6, PITX2
negative regulation of metabolic process (GO:0009892) 1.932PAX6, PITX2
negative regulation of biosynthetic process (GO:0009890) 2.472PAX6, PITX2
regulation of anatomical structure morphogenesis (GO:0022603) 2.792FOXC1, CYP1B1
macromolecular complex subunit organization (GO:0043933) 2.142FOXC1, CYP1B1
negative regulation of cellular metabolic process (GO:0031324) 2.012PAX6, PITX2
lacrimal gland development (GO:0032808) 7.782PAX6, FOXC1
homeostatic process (GO:0042592) 2.612PAX6, FOXC1
embryo development (GO:0009790) 4.22FOXC1, PITX2
regulation of vasculature development (GO:1901342) 4.262FOXC1, CYP1B1
embryo development ending in birth or egg hatching (GO:0009792) 4.352FOXC1, PITX2
neuron migration (GO:0001764) 5.02PAX6, PITX2
axis specification (GO:0009798) 5.422PAX6, PITX2
regulation of cell differentiation (GO:0045595) 2.422PAX6, FOXC1
pituitary gland development (GO:0021983) 6.332PAX6, PITX2
ameboidal-type cell migration (GO:0001667) 4.712CYP1B1, PITX2
regulation of cell death (GO:0010941) 2.432FOXC1, CYP1B1
regulation of apoptotic process (GO:0042981) 2.52FOXC1, CYP1B1
in utero embryonic development (GO:0001701) 4.42FOXC1, PITX2
negative regulation of macromolecule metabolic process (GO:0010605) 2.012PAX6, PITX2
protein complex subunit organization (GO:0071822) 2.62FOXC1, CYP1B1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122PAX6, PITX2
blood vessel development (GO:0001568) 4.952PAX6, FOXC1
negative regulation of multicellular organismal process (GO:0051241) 2.842PAX6, FOXC1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62PAX6, PITX2
negative regulation of developmental process (GO:0051093) 3.172PAX6, FOXC1
regulation of programmed cell death (GO:0043067) 2.492FOXC1, CYP1B1
tissue morphogenesis (GO:0048729) 3.872FOXC1, PITX2
extracellular structure organization (GO:0043062) 4.02FOXC1, CYP1B1
regulation of angiogenesis (GO:0045765) 4.362FOXC1, CYP1B1
chordate embryonic development (GO:0043009) 4.382FOXC1, PITX2
positive regulation of cell proliferation (GO:0008284) 3.012PAX6, PITX2
negative regulation of cell proliferation (GO:0008285) 3.262PAX6, CYP1B1
reproductive structure development (GO:0048608) 4.082FOXC1, PITX2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552PAX6, PITX2
cell proliferation (GO:0008283) 3.232FOXC1, PITX2
cardiac muscle tissue morphogenesis (GO:0055008) 5.82FOXC1, PITX2
neurological system process (GO:0050877) 2.642PAX6, CYP1B1
epithelial cell differentiation (GO:0030855) 3.982PAX6, PITX2
visual perception (GO:0007601) 4.412PAX6, CYP1B1
sensory perception (GO:0007600) 2.932PAX6, CYP1B1
sensory perception of light stimulus (GO:0050953) 4.42PAX6, CYP1B1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712PAX6, PITX2
negative regulation of RNA biosynthetic process (GO:1902679) 2.72PAX6, PITX2
reproductive process (GO:0022414) 2.552FOXC1, PITX2
response to stress (GO:0006950) 1.82PAX6, CYP1B1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752PAX6, PITX2
regionalization (GO:0003002) 4.242PAX6, FOXC1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472PAX6, PITX2
iris morphogenesis (GO:0061072) 7.532PAX6, PITX2
response to chemical (GO:0042221) 1.982CYP1B1, PITX2
response to organic substance (GO:0010033) 2.22CYP1B1, PITX2
positive regulation of cell differentiation (GO:0045597) 3.012PAX6, FOXC1
heart development (GO:0007507) 4.242FOXC1, PITX2
single organism reproductive process (GO:0044702) 2.732FOXC1, PITX2
odontogenesis of dentin-containing tooth (GO:0042475) 5.522FOXC1, PITX2
anterior/posterior pattern specification (GO:0009952) 4.712PAX6, FOXC1
developmental process involved in reproduction (GO:0003006) 3.362FOXC1, PITX2
epidermal cell differentiation (GO:0009913) 5.132PAX6, PITX2
negative regulation of RNA metabolic process (GO:0051253) 2.662PAX6, PITX2
odontogenesis (GO:0042476) 5.192FOXC1, PITX2
negative regulation of gene expression (GO:0010629) 2.482PAX6, PITX2
regulation of molecular function (GO:0065009) 1.782CYP1B1, PITX2
collagen fibril organization (GO:0030199) 6.072FOXC1, CYP1B1
extracellular matrix organization (GO:0030198) 4.012FOXC1, CYP1B1
negative regulation of cellular biosynthetic process (GO:0031327) 2.492PAX6, PITX2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532PAX6, PITX2
muscle tissue morphogenesis (GO:0060415) 5.622FOXC1, PITX2

NET-GE enrichment

Term New enriched termICP valueGenes
cell development (GO:0048468) -3.280.046PAX6, FOXC1, PITX2
lacrimal gland development (GO:0032808) -7.780.003PAX6, FOXC1
positive regulation of gene expression (GO:0010628) -2.350.012PAX6, CYP1B1, PITX2, FOXC1
segmentation (GO:0035282) NEW5.80.002PAX6, FOXC1, PITX2
anatomical structure morphogenesis (GO:0009653) -2.530.012PAX6, CYP1B1, PITX2, FOXC1
pattern specification process (GO:0007389) -3.790.018PAX6, FOXC1, PITX2
artery morphogenesis (GO:0048844) NEW5.880.003PAX6, FOXC1, PITX2
regulation of organ growth (GO:0046620) NEW5.410.012PAX6, FOXC1, PITX2
blood vessel morphogenesis (GO:0048514) -5.320.0PAX6, CYP1B1, PITX2, FOXC1
extracellular structure organization (GO:0043062) -4.00.012PAX6, CYP1B1, PITX2, FOXC1
cell migration (GO:0016477) -3.120.001PAX6, CYP1B1, PITX2, FOXC1
organ morphogenesis (GO:0009887) -3.550.022PAX6, FOXC1, PITX2
regulation of cell migration (GO:0030334) -3.230.043PAX6, CYP1B1, PITX2
male sex determination (GO:0030238) NEW7.160.014PAX6, PITX2
cardiac muscle tissue morphogenesis (GO:0055008) -5.80.003PAX6, FOXC1, PITX2
transcription from RNA polymerase II promoter (GO:0006366) -3.380.035PAX6, FOXC1, PITX2
rhombomere development (GO:0021546) NEW7.780.005PAX6, PITX2
ventricular septum morphogenesis (GO:0060412) NEW6.590.049PAX6, PITX2
iris morphogenesis (GO:0061072) -7.530.003PAX6, PITX2
cellular component movement (GO:0006928) -2.610.013PAX6, CYP1B1, PITX2, FOXC1
locomotion (GO:0040011) -2.910.002PAX6, CYP1B1, PITX2, FOXC1
odontogenesis of dentin-containing tooth (GO:0042475) -5.520.044PAX6, FOXC1, PITX2
sensory organ development (GO:0007423) -4.820.032PAX6, FOXC1, PITX2
cell motility (GO:0048870) -3.020.001PAX6, CYP1B1, PITX2, FOXC1
paraxial mesoderm formation (GO:0048341) NEW7.780.001FOXC1, PITX2
odontogenesis (GO:0042476) -5.190.021PAX6, FOXC1, PITX2
collagen fibril organization (GO:0030199) -6.070.016FOXC1, CYP1B1
extracellular matrix organization (GO:0030198) -4.010.011PAX6, CYP1B1, PITX2, FOXC1
eye development (GO:0001654) -5.070.014PAX6, FOXC1, PITX2
camera-type eye development (GO:0043010) -5.360.004PAX6, FOXC1, PITX2
digestive tract morphogenesis (GO:0048546) NEW6.780.047PAX6, PITX2
muscle tissue morphogenesis (GO:0060415) -5.620.029PAX6, FOXC1, PITX2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.64PAX6, CYP1B1, PITX2, FOXC1
cell part (GO:0044464) 0.114PAX6, CYP1B1, PITX2, FOXC1
intracellular organelle (GO:0043229) 0.514PAX6, CYP1B1, PITX2, FOXC1
intracellular part (GO:0044424) 0.284PAX6, CYP1B1, PITX2, FOXC1
membrane-bounded organelle (GO:0043227) 0.474PAX6, CYP1B1, PITX2, FOXC1
organelle (GO:0043226) 0.44PAX6, CYP1B1, PITX2, FOXC1
cytoplasm (GO:0005737) 1.013PAX6, FOXC1, PITX2
intracellular organelle part (GO:0044446) 0.813PAX6, FOXC1, CYP1B1
nucleus (GO:0005634) 1.073PAX6, FOXC1, PITX2
macromolecular complex (GO:0032991) 1.353PAX6, FOXC1, PITX2
organelle part (GO:0044422) 0.793PAX6, FOXC1, CYP1B1
nucleoplasm (GO:0005654) 1.892PAX6, FOXC1
nuclear chromosome part (GO:0044454) 3.672PAX6, FOXC1
nuclear chromatin (GO:0000790) 4.422PAX6, FOXC1
nuclear part (GO:0044428) 1.552PAX6, FOXC1
chromatin (GO:0000785) 3.992PAX6, FOXC1
chromosomal part (GO:0044427) 3.182PAX6, FOXC1

NET-GE enrichment

Term New enriched termICP valueGenes
clathrin-coated vesicle membrane (GO:0030665) NEW5.60.024PAX6, PITX2
nuclear chromosome part (GO:0044454) -3.670.031PAX6, FOXC1, PITX2
nuclear chromatin (GO:0000790) -4.420.014PAX6, FOXC1, PITX2
chromatin (GO:0000785) -3.990.022PAX6, FOXC1, PITX2