Disease table of AMYOTROPHIC LATERAL SCLEROSIS OMIM ID: PS105400

Gene-disease associations table

Gene	Associated with AMYOTROPHIC LATERAL SCLEROSIS in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
FUS	ClinVar, OMIM, HUMSAVAR	HGNC link	16p11.2	2	PS190300, PS105400
VAPB	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.32	2	PS105400, 182980
CHMP2B	ClinVar, OMIM, HUMSAVAR	HGNC link	3p11.2	2	PS105400, 600795
MATR3	ClinVar, OMIM, HUMSAVAR	HGNC link	5q31.2	1	PS105400
CHCHD10	ClinVar, OMIM, HUMSAVAR	HGNC link	22q11.23	3	PS105400, 616209, 615048
DCTN1	OMIM, HUMSAVAR	HGNC link	2p13.1	3	PS105400, 168605, 607641
OPTN	ClinVar, OMIM, HUMSAVAR	HGNC link	10p13	3	PS105400, 606657, 137760
TBK1	ClinVar, OMIM, HUMSAVAR	HGNC link	12q14.2	1	PS105400
UBQLN2	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp11.21	1	PS105400
NEFH	OMIM	HGNC link	22q12.2	2	PS118220, PS105400
FIG4	ClinVar, OMIM, HUMSAVAR	HGNC link	6q21	4	PS118220, PS105400, 216340, 612691
SETX	ClinVar, OMIM, HUMSAVAR	HGNC link	9q34.13	2	PS105400, 606002
ERBB4	ClinVar, OMIM, HUMSAVAR	HGNC link	2q34	1	PS105400
SOD1	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.11	1	PS105400
HNRNPA1	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.13	2	PS167320, PS105400
ALS2	ClinVar, OMIM	HGNC link	2q33.1	3	606353, 607225, PS105400
VCP	ClinVar, OMIM, HUMSAVAR	HGNC link	9p13.3	3	PS118220, PS105400, PS167320
TUBA4A	ClinVar, OMIM, HUMSAVAR	HGNC link	2q35	1	PS105400
TARDBP	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.22	1	PS105400
SQSTM1	ClinVar, OMIM, HUMSAVAR	HGNC link	5q35.3	2	PS105400, PS167250
ANG	ClinVar, OMIM, HUMSAVAR	HGNC link	14q11.2	1	PS105400
PRPH	OMIM	HGNC link	12q13.12	1	PS105400
PFN1	ClinVar, OMIM, HUMSAVAR	HGNC link	17p13.2	1	PS105400
C9orf72	ClinVar, OMIM	HGNC link	9p21.2	1	PS105400
SPG11	ClinVar, OMIM	HGNC link	15q21.1	3	PS118220, PS303350, PS105400
ATXN2	ClinVar, OMIM	HGNC link	12q24.12	3	PS164400, PS168600, PS105400
SIGMAR1	ClinVar, OMIM, HUMSAVAR	HGNC link	9p13.3	2	PS105400, 605726

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
9p13.3	2	VCP, SIGMAR1

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
9p13	2	VCP, SIGMAR1
12q13	2	PRPH, HNRNPA1

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
22q1	2	CHCHD10, NEFH
12q1	3	PRPH, HNRNPA1, TBK1
2q3	3	ALS2, TUBA4A, ERBB4
9p1	2	VCP, SIGMAR1
5q3	2	MATR3, SQSTM1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
2q	3	ALS2, TUBA4A, ERBB4
5q	2	MATR3, SQSTM1
12q	4	PRPH, ATXN2, HNRNPA1, TBK1
9p	3	VCP, SIGMAR1, C9orf72
22q	2	CHCHD10, NEFH

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	4	PRPH, ATXN2, HNRNPA1, TBK1
22	2	CHCHD10, NEFH
2	4	ALS2, TUBA4A, DCTN1, ERBB4
5	2	MATR3, SQSTM1
9	4	SETX, VCP, SIGMAR1, C9orf72

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
FUS	YES	3	DDIT3, CXCL8, MDM2	0
PPARD	NO	11	TXN, SAT1, SOD1, LPL, ANG, CAT, TIMP1, HSD11B2, ANGPTL4, SLC25A20, PDK4	2	ANG, SOD1
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	ATXN2, SQSTM1
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	SOD1, SQSTM1
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	OPTN, SQSTM1

regulated gene	associated to this disease	# TFs	TFs
FUS	YES	1	TBP
OPTN	YES	2	NFKB1, RELA
ERBB4	YES	1	WWP1
SOD1	YES	7	SP1, EGR1, PPARD, NFE2L2, CEBPD, MSX2, MTF1
HNRNPA1	YES	1	MYC
VCP	YES	2	PBX1, ELF2
SQSTM1	YES	4	SP1, SPDEF, NFKB1, ETS1
ANG	YES	1	PPARD
ATXN2	YES	2	ZNF350, ETS1
SIGMAR1	YES	1	ATF4

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
FUS	VAPB	No	7	VCP, CAND1, UBC, RPN2, NTRK1, YBX1, UBL4A
FUS	CHMP2B	No	3	RAB7A, PHGDH, SQSTM1
FUS	MATR3	Yes	46	HNRNPK, HNRNPA1, TARDBP, PARK2, MATR3, SAFB2, OBSL1, ATP5A1, RPA1, EWSR1, RPA3, ILF3, DDX5, RTCB, PTBP1, HNRNPDL, HNRNPH1, RBMX, SRSF9, COPS5, RPA2, YBX1, FN1, CUL1, FBXW11, HNRNPL, WWOX, PTBP2, HNRNPU, HNRNPA3, UBC, HNRNPF, C14ORF166, CDK2, NEDD8, DDX17, AURKA, CAND1, REV, TAF15, NTRK1, SF3A3, UBE2I, ITGA4, CUL3, CUL7
FUS	DCTN1	No	11	SAP30BP, DYNC1H1, NPLOC4, SF3A3, TDRD3, NAP1L1, CUL3, NTRK1, SNW1, GRB2, SF3B3
FUS	OPTN	No	7	PARK2, TNIP1, YWHAZ, UBC, YWHAQ, SQSTM1, GNAS
FUS	TBK1	No	9	TXLNA, RELA, MCM2, HSP90AA1, TNIP1, ESR1, NTRK1, CUL1, SQSTM1
FUS	UBQLN2	No	10	CUL5, HNRNPA1, TARDBP, HERC6, NPLOC4, HNRNPA3, UBC, HNRNPU, RPA2, NTRK1
FUS	NEFH	No	1	GRB2
FUS	SETX	No	3	UBE2I, ALB, CDC5L
FUS	ERBB4	No	5	GRB2, PIK3R2, HSP90AA1, ABL1, WWOX
FUS	SOD1	No	16	HSPA9, HSPA8, CFL1, MDH2, GAPDH, PRDX1, OAT, PPIA, EWSR1, ALB, TKT, ENO1, LDHB, UBC, LDHA, PGM1
FUS	HNRNPA1	Yes	101	DDX5, TARDBP, CUL4B, PICALM, SNRPD2, ALB, RBMX, ILF3, CDC5L, LDHA, VCP, H3F3A, SYNCRIP, ALDOA, CTNNB1, EEF1A1, TAF15, LMNA, CFL1, MAPK13, DHX15, GSTP1, CUL5, NEDD8, SCARNA22, PCBP2, ESR1, CUL3, HNRNPD, HNRNPA1, PRDX1, ATP5A1, PGK1, HSP90AB1, EWSR1, SNW1, PRMT1, PTBP1, RPS5, RPA2, RPS6KB2, HSPA9, PFN1, GAPDH, HSP90AA1, HNRNPA3, ACTB, EEF2, HSPD1, NUDT21, AURKA, SF3A2, REV, YWHAQ, HNRNPK, RTCB, MATR3, DCUN1D1, RPA1, PHGDH, HSPA5, CPSF6, SFPQ, MCM2, EEF1G, RPS8, ENO1, OBSL1, DDX1, MRPS18B, HNRNPF, CDK2, PARK2, HNRNPU, PKM, FBXW11, NTRK1, ITGA4, CUL7, ATP5B, FN1, CUL1, SAFB2, RPA3, HNRNPDL, VCAM1, NONO, DNAJC10, COPS5, ANXA5, YWHAZ, HNRNPL, SRPK1, C14ORF166, CUL2, PPIA, HSPA8, DDX17, CAND1, HNRNPH1, UBE2I
FUS	ALS2	No	1	VCP
FUS	VCP	Yes	71	HNRNPK, HNRNPA1, VCP, CHEK1, RPS8, CUL3, OBSL1, RPS9, DNAJC10, TUBB, EZH2, PIK3R2, HSP90AB1, HSPA5, ST13, PHB, GRB2, F7, TARDBP, CCT5, UBC, CCT3, VCAM1, NPLOC4, SIRT7, SLC25A3, CCT8, COPS5, CCT6A, RPL9, CCT4, FN1, SIK2, YWHAZ, UFD1L, CCT7, CUL4A, LMNA, ANXA5, ACACA, CCT2, HSP90AA1, CUL1, ACTB, SUZ12, NPM1, HSPD1, CUL2, UBL4A, TOMM34, TKT, CUL5, TCP1, HSPA8, HSP90B1, CDK2, RBBP4, PARK2, TP63, RPN2, MRPS18B, HNRNPH1, PKM, FBXW11, ESR1, NTRK1, RAB7A, ITGA4, YWHAQ, MCM2, CUL7
FUS	TUBA4A	No	31	HNRNPK, CDC5L, CUL1, ILF3, DCUN1D1, CAND1, SNW1, HSPA5, COPS6, MCM2, CUL4B, RPA1, TUBA1A, COPS5, RPA2, YBX1, EEF1A1, OBSL1, CUL4A, SIK2, CUL2, CUL5, NEDD8, PARK2, PGK1, TUBB, REV, PKM, CUL3, RPA3, CUL7
FUS	TARDBP	Yes	62	HNRNPK, HNRNPA1, SLC25A5, VCP, NPM1, SRPK1, MATR3, RPA1, WWOX, RPS9, SCARNA22, PHGDH, HSPA5, TUBA1B, HSP90AA1, ILF3, DDX5, ARHGEF28, LSM12, HNRNPDL, MCM2, VCAM1, HNRNPU, RBMX, SYNCRIP, RPL9, SNW1, CDC5L, FN1, RPS14, ITGA4, SQSTM1, PCBP2, OTUB1, ATXN2L, RPL4, RPA2, HNRNPA3, EEF2, BMI1, RPL14, RPL11, PDIA3, CUL2, TARDBP, RPL12, HSPA8, PTBP1, DDX17, EEF1G, SERBP1, PARK2, ATP5A1, CAND1, KPNA2, TUBB, HNRNPH1, CUL3, RPA3, NTRK1, FAM98A, CUL7
FUS	SQSTM1	Yes	20	CUL2, CEP78, PSMD12, TARDBP, ARHGEF28, YWHAZ, CUL1, LDHA, PARK2, NPM1, UBC, TUBA1A, PIK3R2, TKT, CUL7, NTRK1, HSPA5, MAP3K3, CUL3, SQSTM1
FUS	PRPH	No	4	ILF3, MTHFD1, HNRNPU, CUL3
FUS	PFN1	Yes	17	OBSL1, FN1, HNRNPA1, CUL7, CDK2, SRPK1, MCM2, VCAM1, CFL1, CAND1, ACTB, MAPK13, ESR1, NTRK1, YWHAQ, CUL3, ITGA4
FUS	C9orf72	No	1	SRPK1
FUS	ATXN2	No	14	WWOX, CCT5, LSM12, TARDBP, DDX17, KHDRBS3, PARK2, DDX5, CAND1, DHX15, NTRK1, YEATS4, BMI1, CUL3
FUS	SIGMAR1	No	1	ACAT1
VAPB	CHMP2B	No	4	VHL, GOLT1B, BMPR1A, RAB5C
VAPB	MATR3	No	5	NTRK1, UBC, HNRNPC, CAND1, YBX1
VAPB	DCTN1	No	1	NTRK1
VAPB	OPTN	No	1	UBC
VAPB	TBK1	No	2	NTRK1, RB1CC1
VAPB	UBQLN2	No	5	NTRK1, UBC, FAF2, PRKACA, TTC1
VAPB	ERBB4	No	1	ERBB2
VAPB	SOD1	No	3	UBC, OXCT1, SSR4
VAPB	HNRNPA1	No	6	VHL, HNRNPC, VCP, HCVGP1, CAND1, NTRK1
VAPB	ALS2	No	1	VCP
VAPB	VCP	Yes	18	BAG6, VCP, PKN2, RAB3GAP1, SEC22B, SCD, RPN2, NTRK1, PPT1, GET4, FAF1, RAB3GAP2, UBC, VCL, FAF2, UBL4A, INSIG1, VAPA
VAPB	TUBA4A	No	4	VHL, FAF2, CAND1, YBX1
VAPB	TARDBP	No	5	VHL, NTRK1, HNRNPC, CAND1, VCP
VAPB	SQSTM1	No	3	NTRK1, UBC, NBR1
VAPB	PFN1	No	2	NTRK1, CAND1
VAPB	ATXN2	No	4	VHL, NTRK1, CAND1, BAG6
CHMP2B	DCTN1	No	1	PAFAH1B1
CHMP2B	OPTN	No	1	SQSTM1
CHMP2B	TBK1	No	3	TRAF2, SQSTM1, XPO1
CHMP2B	ERBB4	No	1	USP8
CHMP2B	HNRNPA1	No	4	VHL, PHGDH, MALSU1, XPO1
CHMP2B	VCP	No	2	CHMP4B, RAB7A
CHMP2B	TUBA4A	No	2	VHL, XPO1
CHMP2B	TARDBP	No	4	VHL, PHGDH, USP8, SQSTM1
CHMP2B	SQSTM1	Yes	3	CHMP2B, XPO1, SQSTM1
CHMP2B	ATXN2	No	1	VHL
MATR3	DCTN1	No	11	BTF3, DISC1, CENPE, SF3A3, NAA15, PPP1CA, NAP1L4, CUL3, NTRK1, GSTK1, LGR4
MATR3	OPTN	No	4	UBC, CALM1, PARK2, MAP1LC3A
MATR3	TBK1	No	4	NTRK1, CUL1, EGFR, CCDC8
MATR3	UBQLN2	No	8	HNRNPA1, TARDBP, SNAP23, HNRNPA3, UBC, HNRNPU, RPA2, NTRK1
MATR3	SETX	No	1	UBE2I
MATR3	ERBB4	No	2	WWOX, EGFR
MATR3	SOD1	No	3	EWSR1, UBC, PCBP1
MATR3	HNRNPA1	Yes	88	DDX5, TARDBP, EIF4A3, RBM12B, ILF3, CDK9, RPA1, DHX9, NCOA5, AIMP2, RBM3, EED, DDX28, FUBP3, ZNF326, NEDD8, APOBEC3B, HNRNPA0, CUL3, HNRNPA1, RALY, SAFB, ATP5A1, CCDC8, EWSR1, RPA3, PAN2, RBM6, PTBP1, TNK1, RPA2, ERG, AKAP8, SRPK2, SUGP2, HNRNPR, HNRNPA3, ILF2, H2AFX, STAU1, MEPCE, ADAR, AURKA, HNRNPM, MRPL19, HNRNPK, HNRNPH3, RTCB, MATR3, HNRNPH2, ZNF638, HNRNPA2B1, HNRNPUL2, FBXW11, OBSL1, HNRNPF, HNRNPUL1, CDK2, FUS, DDX3X, PARK2, MCM5, HNRNPU, TAF15, NTRK1, PUF60, ITGA4, CUL7, FN1, RBM14, CUL1, SAFB2, HNRNPDL, REV, RBMX, KHDRBS1, COPS5, HNRNPL, ALYREF, FAM120A, C14ORF166, YLPM1, HNRNPC, DDX17, CAND1, HNRNPH1, IFIT2, UBE2I
MATR3	VCP	No	32	HNRNPK, HNRNPA1, RUVBL2, TARDBP, HNRNPH3, CUL1, NUMA1, FN1, HNRNPH2, CCDC8, RCN1, CRY2, CALR, COPS5, FBXW11, OBSL1, RANBP2, SENP3, UBC, MAP1LC3A, ZNF326, RBFOX2, CDK2, FUS, PARK2, SRSF3, HNRNPH1, CUL3, SAP18, NTRK1, ITGA4, CUL7
MATR3	TUBA4A	No	19	STAU1, OBSL1, RUVBL1, EGFR, NEDD8, CUL1, CUL3, PARK2, HNRNPK, CAND1, RPA2, REV, COPS5, RPA1, RUVBL2, YBX1, RPA3, ILF3, CUL7
MATR3	TARDBP	Yes	48	HNRNPK, HNRNPA1, RALY, PCBP1, MATR3, HNRNPU, HNRNPUL1, HNRNPH2, ATP5A1, RPA1, RPA3, ILF3, DDX5, TARDBP, PTBP1, HNRNPDL, HNRNPH1, RBMX, HNRNPA2B1, DHX9, HNRNPUL2, FN1, ITGA4, WWOX, RPA2, EED, HNRNPR, FAM120A, HNRNPF, ILF2, RUVBL2, FUBP3, STAU1, HNRNPA3, HNRNPC, ADAR, FUS, DDX3X, PARK2, RPL7, CAND1, DDX17, HNRNPM, CUL3, NTRK1, DNAJB6, HNRNPA0, CUL7
MATR3	SQSTM1	No	16	CALM1, TARDBP, FUS, PPHLN1, CUL3, PARK2, EEF1D, HNRNPA2B1, UBC, CDK9, CUL7, MAP1LC3A, NTRK1, TAT, CUL1, PAN2
MATR3	PRPH	No	3	HNRNPU, ILF3, CUL3
MATR3	PFN1	No	11	FN1, HNRNPA1, CDK2, FUS, OBSL1, CAND1, SET, CUL7, NTRK1, CUL3, ITGA4
MATR3	ATXN2	No	12	GFI1B, WWOX, TARDBP, DDX17, PARK2, DDX5, CAND1, KHDRBS1, CUL3, EGFR, NTRK1, RBFOX2
DCTN1	OPTN	No	2	RAB8A, MAP1LC3B
DCTN1	TBK1	No	7	MAP1LC3B, CDC37, CEP44, HMMR, AKT1, NTRK1, IRF3
DCTN1	UBQLN2	No	3	NTRK1, NPLOC4, EMC3
DCTN1	NEFH	No	1	GRB2
DCTN1	ERBB4	No	1	GRB2
DCTN1	SOD1	No	2	DYNLT1, SPTBN1
DCTN1	HNRNPA1	No	18	NEDD1, SMURF1, MARK2, SEC16A, AURKB, ANXA1, CUL3, YTHDF2, UPF1, NNT, LTV1, SNW1, CLTC, NTRK1, NXF1, IGF2BP2, KIAA0368, MOV10
DCTN1	VCP	No	23	AKT1, MARK2, CLASP1, VIM, PLK1, ARHGEF2, NEK2, SEC16A, POLR2B, NPLOC4, DYNC1I2, SMURF1, SPC24, SUPT16H, DYNC1LI1, STAT1, CDC37, MAP7D3, CCNB1, NTRK1, GRB2, TTK, CUL3
DCTN1	TUBA4A	No	7	MAPT, POLR2B, CUL3, SNW1, PEX14, NXF1, MOV10
DCTN1	TARDBP	No	12	YTHDF2, TSR1, NACA, CUL3, UPF1, YTHDC2, NUBP2, NTRK1, NXF1, IGF2BP2, SNW1, MOV10
DCTN1	SQSTM1	No	9	MAP1LC3B, MAPT, CDC37, NDUFA5, CUL3, CCNB1, NTRK1, NXF1, MOV10
DCTN1	PRPH	No	2	VIM, CUL3
DCTN1	PFN1	No	2	NTRK1, CUL3
DCTN1	ATXN2	No	5	NTRK1, SEC16A, CUL3, NXF1, MOV10
DCTN1	SIGMAR1	No	3	NXF1, PDZD11, MOV10
OPTN	TBK1	Yes	11	TAX1BP1, MAP1LC3B, RNF11, TRAF3, TBK1, STX12, CYLD, TNF, TNIP1, OPTN, SQSTM1
OPTN	UBQLN2	No	4	EPS15, HTT, RNF11, UBC
OPTN	ERBB4	No	1	PIAS4
OPTN	SOD1	Yes	3	UBC, SOD1, OPTN
OPTN	HNRNPA1	No	4	PARK2, YWHAQ, HSPB1, YWHAZ
OPTN	ALS2	No	1	YWHAB
OPTN	VCP	No	15	TAX1BP1, RAB11B, HTT, RAB10, YWHAH, PARK2, CDKN1A, RAB14, YWHAG, YWHAB, MAP1LC3A, UBC, HSPB1, YWHAQ, YWHAZ
OPTN	TUBA4A	No	2	PARK2, HSPB1
OPTN	TARDBP	No	3	PARK2, HSPB1, SQSTM1
OPTN	SQSTM1	Yes	19	CALM1, MAP1LC3A, MAP1LC3B, YWHAZ, HTT, GABARAP, TBK1, PARK2, RIPK1, MAP1LC3C, UBC, HSPB1, SQSTM1, OPTN, ATG8, CYLD, GABARAPL2, DAZAP2, GABARAPL1
OPTN	PFN1	No	1	YWHAQ
OPTN	ATXN2	No	1	PARK2
TBK1	UBQLN2	No	2	RNF11, NTRK1
TBK1	SETX	No	1	CNTROB
TBK1	ERBB4	No	5	NCK1, SYK, HSP90AA1, EGFR, NEDD4
TBK1	SOD1	No	1	OPTN
TBK1	HNRNPA1	No	12	HSP90AA1, IFIT3, MCM2, YWHAE, NFKBIA, CCDC8, XIAP, XPO1, ESR1, NTRK1, CUL1, APP
TBK1	VCP	No	17	NFKBIA, TAX1BP1, AKT1, SKP1, IKBKE, MCM2, CDC37, CCDC8, PPP6C, BTRC, YWHAE, HSP90AA1, ESR1, NTRK1, NFKB1, CUL1, NFKB2
TBK1	TUBA4A	No	4	CUL1, MCM2, EGFR, XPO1
TBK1	TARDBP	No	6	AGO2, MCM2, HSP90AA1, SQSTM1, NTRK1, APP
TBK1	SQSTM1	Yes	16	TRAF1, MAP1LC3B, MED4, SASS6, CALCOCO2, CDC37, XPO1, MBP, CUL1, CYLD, CEP135, OPTN, NTRK1, IKBKG, TBK1, SQSTM1
TBK1	PFN1	No	4	NTRK1, MCM2, NCK1, ESR1
TBK1	C9orf72	No	2	REL, APP
TBK1	ATXN2	No	2	NTRK1, EGFR
UBQLN2	ERBB4	No	1	YAP1
UBQLN2	SOD1	No	4	UBC, USP9X, UBE3A, ADSL
UBQLN2	HNRNPA1	Yes	10	UBQLN2, HNRNPA1, TARDBP, CUL5, ELAVL1, HNRNPA3, HNRNPU, RPA2, NTRK1, P4HB
UBQLN2	VCP	No	23	PSMC1, TARDBP, SHFM1, INSIG2, HNRNPA1, ATXN7, HTT, RAD23A, NPLOC4, UBQLN1, BID, P4HB, CALU, ELAVL1, NTRK1, PSMA6, PSMA2, HERPUD1, CUL5, TPD52L2, VBP1, UBC, FAF2
UBQLN2	TUBA4A	No	4	FBXO25, CUL5, FAF2, RPA2
UBQLN2	TARDBP	Yes	10	UBQLN2, HNRNPA1, TARDBP, HNRNPU, ELAVL1, HNRNPA3, UBQLN1, PSMA6, RPA2, NTRK1
UBQLN2	SQSTM1	No	8	TARDBP, PSMC2, HTT, RAD23A, NTRK1, EDEM1, UBC, BID
UBQLN2	ANG	No	1	RNH1
UBQLN2	PRPH	No	2	HNRNPU, CALU
UBQLN2	PFN1	No	3	NTRK1, HNRNPA1, ELAVL1
UBQLN2	C9orf72	No	1	ELAVL1
UBQLN2	ATXN2	No	3	NTRK1, TARDBP, SHFM1
NEFH	ERBB4	No	1	GRB2
NEFH	HNRNPA1	No	1	GAN
NEFH	VCP	No	1	GRB2
NEFH	PRPH	No	1	GAN
SETX	SOD1	No	1	ALB
SETX	HNRNPA1	No	6	MEF2A, CDC5L, SMN1, ALB, BRCA1, UBE2I
SETX	VCP	No	4	APOA1, BRCA1, SUMO2, SUMO1
SETX	TUBA4A	No	2	ISLR, CDC5L
SETX	TARDBP	No	2	BRCA1, CDC5L
SETX	SQSTM1	No	1	MLST8
SETX	ANG	No	1	PTEN
SETX	ATXN2	No	2	CARD8, SKAP1
ERBB4	SOD1	No	1	HDAC6
ERBB4	HNRNPA1	No	2	TP53, HSP90AA1
ERBB4	VCP	No	6	LRIG1, MDM2, TP53, HSP90AA1, PIK3R2, GRB2
ERBB4	TUBA4A	No	2	EGFR, TP53
ERBB4	TARDBP	No	5	HDAC6, WWOX, TRIM28, HSP90AA1, USP8
ERBB4	SQSTM1	No	6	HDAC6, STAT5A, PIK3R2, CD44, TP53, NCOR1
ERBB4	ANG	No	2	TP53, MDM2
ERBB4	PFN1	No	1	NCK1
ERBB4	ATXN2	No	2	WWOX, EGFR
SOD1	HNRNPA1	No	12	HSPA9, HSPA8, GAPDH, PRDX1, CFL1, PPIA, ALB, CRIP1, PABPC4, EWSR1, LDHA, ENO1
SOD1	VCP	No	17	PSMD4, COMMD1, HSPA8, STIP1, EIF5A, NME2, HSPA4, HSPE1, PPP2CA, AMFR, TKT, TXN2, UBC, DSTN, CEP55, RNF19A, STUB1
SOD1	TUBA4A	No	1	ENO2
SOD1	TARDBP	No	6	HSPA8, HDAC6, PCBP1, PABPC4, AHCYL1, HSPA4
SOD1	SQSTM1	No	10	PSMD4, BCL2, HDAC6, LDHA, HSPA4, STUB1, OPTN, UBC, LGALS3, TKT
SOD1	PFN1	No	3	DAZAP1, CFL1, STUB1
SOD1	ATXN2	No	1	PABPC4
SOD1	SIGMAR1	No	1	AK2
HNRNPA1	ALS2	No	1	VCP
HNRNPA1	VCP	Yes	83	HSPA1A, HNRNPA1, RPS6, PDCD4, ACTB, ANXA2, RPS8, YWHAE, CANX, TP53, HNRNPH2, HSPD1, PNO1, NFKBIA, HSP90AB1, P4HB, HSPA5, SRRM2, ZNF326, RNF2, EIF4A2, HNRNPH1, IQGAP1, MARK2, CUL7, TARDBP, ARRB2, MCM2, VCAM1, DNAJC10, DAP3, CDKN2AIP, COPS5, FBXO6, PRPF4, HDAC5, SMURF1, CUL1, ITGA4, OBSL1, PRMT3, LMNA, YWHAZ, MRPS23, CDK2, ANXA5, VCP, NUP205, ELAVL1, G3BP2, PRPF31, HSP90AA1, HNRNPH3, PPP2R1A, CUL2, TOP1, FN1, BRCA1, DSP, CUL5, NOS2, HSPA8, PRPF19, WDR82, ZFR, YWHAQ, CD4, PARK2, EPPK1, CCDC8, RPS3A, FUS, MRPS18B, HSPB1, PKM, FBXW11, ESR1, NTRK1, RPS3, HNRNPK, PSMA3, SEC16A, CUL3
HNRNPA1	TUBA4A	No	42	HNRNPK, PRPF8, CDC5L, CUL1, HSPA1A, XPO1, DCUN1D1, MYH9, CD81, IGSF8, NXF1, SRRM2, HSPA5, CUL2, RPS27A, ARRB2, CUL4B, PGK1, RPA1, COPS5, RPA2, ARRB1, EEF1A1, VHL, OBSL1, TP53, SNW1, ICAM1, MOV10, STAU1, CUL5, NEDD8, PARK2, CAND1, REV, HSPB1, PKM, CUL3, RPA3, ILF3, MCM2, CUL7
HNRNPA1	TARDBP	Yes	129	DDX5, TARDBP, HNRNPK, DDX21, SNRNP200, DHX36, ILF3, RPS7, VCP, RPA1, SYNCRIP, DHX9, FBXO6, MSI2, ITGA4, DHX30, EED, G3BP1, UPF1, FUBP3, HNRNPA0, PKP1, YTHDF2, XRN1, PCBP2, YBX3, MRPL48, APP, CUL3, HNRNPA1, RPS6, RALY, PARK2, KHDRBS2, HNRNPUL1, ATP5A1, SCARNA22, NXF1, PTBP1, DAP3, HSPB1, MRPL22, RPA2, CAPRIN1, LARP1, PABPC4, MRPS27, HSP90AA1, HNRNPA3, ILF2, EEF2, STAU1, ADAR, RPS3A, NCBP1, HNRNPM, XRCC5, PSMA3, SRRT, HNRNPR, PABPC1, MATR3, DDX6, HNRNPH2, PRRC2A, PHGDH, HSPA5, DIMT1, EIF3H, CUL7, MCM2, SRSF6, HNRNPA2B1, HNRNPAB, RPL26, HNRNPUL2, PURA, BRCA1, EEF1G, CSTF1, VHL, SRSF7, RNF2, MOV10, UBQLN2, PRPF19, FUS, G3BP2, DDX3X, XRCC6, MRPL44, DDX17, HNRNPU, TOP1, RBM39, NTRK1, NKRF, DCD, FN1, SSB, RPS3, MYH9, CAND1, SNW1, MRPS22, HNRNPDL, VCAM1, RBMX, RPSA, CDC5L, IGF2BP2, NCL, SRPK1, FAM120A, JUP, KHSRP, ELAVL1, XRN2, CUL2, DSP, HNRNPC, HSPA8, H1FX, ZFR, GNB2L1, HNRNPH1, NOP56, RPA3, CCAR2
HNRNPA1	SQSTM1	No	21	CUL2, PAN2, CUL7, TP53, TARDBP, FUS, LDHA, PARK2, CDK9, XPO1, HNRNPA2B1, CUL1, MRPL38, NXF1, HSPB1, YWHAZ, NTRK1, HSPA5, SRRM2, CUL3, MOV10
HNRNPA1	ANG	No	1	TP53
HNRNPA1	PRPH	No	5	GAN, KRT15, ILF3, HNRNPU, CUL3
HNRNPA1	PFN1	Yes	23	FN1, HNRNPA1, LIG4, ASB2, MLLT4, VCAM1, ITGA4, OBSL1, ELAVL1, SRPK1, ACTB, MAPK13, CFL1, CDK2, FUS, CAND1, ACAA2, CUL3, ESR1, NTRK1, YWHAQ, MCM2, CUL7
HNRNPA1	C9orf72	No	3	ELAVL1, SRPK1, APP
HNRNPA1	ATXN2	No	18	VHL, DDX5, TARDBP, PABPC1, DDX17, PARK2, SEC16A, KHDRBS2, CAND1, ADA, KHDRBS1, DHX15, DDX6, PABPC4, NTRK1, NXF1, CUL3, MOV10
HNRNPA1	SIGMAR1	No	2	NXF1, MOV10
ALS2	VCP	Yes	2	VCP, YWHAB
ALS2	TARDBP	No	1	VCP
VCP	TUBA4A	No	33	HSPA1A, CUL1, HNRNPK, PSMC4, TP53, CUL4A, TUBB3, HSPA5, SRRM2, TUBB4B, ARRB2, HAUS1, TUBA1C, POLR2B, HSPB1, COPS5, TUBGCP2, OBSL1, TUBB2B, RBM23, SIK2, DNAJB11, IQCB1, RUVBL2, CUL2, CUL5, PARK2, TUBB, PKM, CUL7, FAF2, MCM2, CUL3
VCP	TARDBP	Yes	63	USP10, HNRNPA1, BAG2, RPS11, HSPA4, TARDBP, HNRNPK, RPS3, HNRNPH2, RPS9, DAP3, RPS6, RPL9, HSPA5, NDRG1, NSFL1C, HSP90AA1, VCP, RPS4X, RPL23, HDAC6, RPL6, UBQLN1, HSPB1, FBXO6, PARK2, BRCA1, FN1, RPL13, ITGA4, ADRB2, ZFAND2B, RRBP1, RPS25, ELAVL1, GIGYF2, PSMA6, RUVBL2, NPM1, CUL2, TOP1, DSP, FLNB, PDCD6, RNF2, HSPA8, PRPF19, FUS, G3BP2, CDK4, RPL22, RPS3A, TUBB, VCAM1, ZFR, HNRNPH1, RPL18A, CUL3, BCLAF1, NTRK1, PSMA3, MCM2, CUL7
VCP	SQSTM1	No	48	GTF3C3, ISG15, TARDBP, PARK2, CUL1, MAPK1, TP53, CAV1, NPM1, TRIM13, CDK1, HSPA5, SRRM2, STUB1, PRKCD, RAD23A, PIK3R2, CDC37, HSPB1, GBAS, ENV, TRIM21, YWHAZ, PSMD4, UBXN1, NIPSNAP1, BID, MAPK13, UBC, TRAF6, MAP1LC3A, CUL2, ATXN3, TKT, FLNB, SESN2, FUS, HSPA4, CTNND1, MTOR, HTT, CFTR, CASP9, CUL7, CCNB1, NTRK1, CUL3, HIF1A
VCP	ANG	No	2	TP53, MDM2
VCP	PRPH	No	4	CALU, VIM, LNX1, CUL3
VCP	PFN1	No	21	AKAP12, FN1, HNRNPA1, ISG15, CDK2, FUS, VCAM1, MCM2, MAPK3, OBSL1, ELAVL1, CUL7, ACTB, AI837181, ESR1, CRMP1, NTRK1, ITGA4, YWHAQ, CUL3, STUB1
VCP	C9orf72	No	1	ELAVL1
VCP	ATXN2	No	14	CCT5, ACTN1, TARDBP, PARK2, KIAA1279, CUL3, ATXN1, BAG6, SHFM1, TSG101, ISG15, NTRK1, SEC16A, RBFOX2
VCP	SIGMAR1	No	1	CFTR
TUBA4A	TARDBP	No	22	HNRNPK, CDC5L, ILF3, MYH9, TUBB, NXF1, RPA3, MCM2, RPA1, HSPB1, RPA2, SNW1, HSPA5, VHL, RUVBL2, CUL2, MOV10, STAU1, PARK2, CAND1, CUL7, CUL3
TUBA4A	SQSTM1	No	17	CUL2, MYC, CUL7, MAPT, SKI, PARK2, XPO1, TP53, CUL1, TUBA1A, HSPB1, STXBP1, CUL3, NXF1, SRRM2, HSPA5, MOV10
TUBA4A	ANG	No	1	TP53
TUBA4A	PRPH	No	2	ILF3, CUL3
TUBA4A	PFN1	No	6	OBSL1, UCHL5, CAND1, CUL7, MCM2, CUL3
TUBA4A	ATXN2	No	7	VHL, PARK2, CAND1, CUL3, EGFR, NXF1, MOV10
TUBA4A	SIGMAR1	No	2	NXF1, MOV10
TARDBP	SQSTM1	Yes	21	CUL2, HNRNPA2B1, ARHGEF28, TARDBP, NPM1, FUS, RBM45, HSPA4, ASPH, FLNB, NXF1, HSPB1, CUL7, HDAC6, NTRK1, PARK2, HSPA5, IRAK1, CUL3, MOV10, SQSTM1
TARDBP	PRPH	No	3	HNRNPU, ILF3, CUL3
TARDBP	PFN1	No	13	SRPRB, SRPK1, HNRNPA1, CUL7, FUS, MCM2, VCAM1, FN1, CAND1, ITGA4, NTRK1, ELAVL1, CUL3
TARDBP	C9orf72	No	3	ELAVL1, SRPK1, APP
TARDBP	ATXN2	Yes	18	VHL, DDX5, LSM12, PABPC1, DDX17, PARK2, TARDBP, KHDRBS2, WWOX, CAND1, BMI1, DDX6, PABPC4, NTRK1, NXF1, RPL10, CUL3, MOV10
TARDBP	SIGMAR1	No	2	NXF1, MOV10
SQSTM1	ANG	No	1	TP53
SQSTM1	PRPH	No	1	CUL3
SQSTM1	PFN1	No	6	FUS, CUL7, ISG15, NTRK1, STUB1, CUL3
SQSTM1	ATXN2	No	8	TARDBP, PARK2, CUL3, ISG15, NTRK1, NXF1, DLG4, MOV10
SQSTM1	SIGMAR1	No	3	NXF1, CFTR, MOV10
PRPH	PFN1	No	1	CUL3
PRPH	ATXN2	No	1	CUL3
PFN1	C9orf72	No	2	ELAVL1, SRPK1
PFN1	ATXN2	No	4	NTRK1, CUL3, CAND1, ISG15
ATXN2	SIGMAR1	No	2	NXF1, MOV10

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
FUS	TARDBP	No	2	HSP104, DBR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
FUS	VAPB	No	-	2	UBC, TARDBP
FUS	CHMP2B	No	-	1	UBC
FUS	MATR3	No	-	4	UBC, SFPQ, HNRNPK, NONO
FUS	DCTN1	No	-	1	UBC
FUS	OPTN	No	-	1	UBC
FUS	TBK1	No	-	1	UBC
FUS	UBQLN2	No	-	2	UBC, TARDBP
FUS	ERBB4	No	-	1	UBC
FUS	SOD1	No	-	3	UBC, PCBP1, TARDBP
FUS	HNRNPA1	Yes	binding	103	CDC40, TARDBP, HNRNPK, SNRPD2, SNRPD1, RBMX, SNRNP200, RNPS1, SNRPE, POLR2D, DHX9, SNRNP70, SNRPD3, SNRPB, POLR2L, PRPF6, DHX38, SRSF11, SF3A1, POLR2I, CLP1, POLR2A, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, PRPF8, U2AF2, SF3B2, HNRNPL, HNRNPUL1, SF3B1, MAGOH, PTBP1, NCBP2, TNPO1, PCBP2, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, DDX23, HNRNPA3, SF3A2, POLR2B, NUDT21, NCBP1, HNRNPM, UBC, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, POLR2F, SNRPA, CCND1, SRSF6, HNRNPA2B1, POLR2C, GTF2F1, SRSF5, SRSF7, TXNL4A, CD2BP2, SUGP1, SNRPB2, HNRNPA0, PRPF4, HNRNPU, CSTF1, SNRPF, SRSF2, NFX1, SRRM1, CSTF2, YBX1, DNAJC8, POLR2H, UPF3B, PAPOLA, SF3B5, SNRPA1, SRSF1, SNRNP40, SRSF9, PCBP1, RBM5, ALYREF, PRMT1, SF3B3, CCAR1, HNRNPC, PABPN1, HNRNPF, SRSF3, HNRNPH1, CPSF7, POLR2E, NHP2L1
FUS	VCP	No	-	2	UBC, TARDBP
FUS	TUBA4A	No	-	1	UBC
FUS	TARDBP	Yes	activation, binding	7	HNRNPR, HNRNPA1, ATXN2, SNRPB2, PCBP1, HNRNPA2B1, UBC
FUS	SQSTM1	No	-	2	UBC, TARDBP
FUS	PRPH	No	-	1	UBC
FUS	PFN1	No	-	1	UBC
FUS	C9orf72	No	-	1	HNRNPA1
FUS	SPG11	No	-	1	UBC
FUS	ATXN2	Yes	binding	2	UBC, TARDBP
FUS	SIGMAR1	No	-	1	UBC
VAPB	CHMP2B	No	-	1	UBC
VAPB	MATR3	No	-	1	UBC
VAPB	DCTN1	No	-	1	UBC
VAPB	OPTN	No	-	1	UBC
VAPB	TBK1	No	-	1	UBC
VAPB	UBQLN2	No	-	3	UBC, TARDBP, VCP
VAPB	ERBB4	No	-	1	UBC
VAPB	SOD1	No	-	2	UBC, TARDBP
VAPB	HNRNPA1	No	-	2	UBC, TARDBP
VAPB	VCP	Yes	binding	4	UBC, VAPA, TARDBP, FAF1
VAPB	TUBA4A	No	-	1	UBC
VAPB	TARDBP	Yes	binding, activation, expression	2	UBC, VCP
VAPB	SQSTM1	No	-	2	UBC, TARDBP
VAPB	PRPH	No	-	1	UBC
VAPB	PFN1	No	-	1	UBC
VAPB	SPG11	No	-	1	UBC
VAPB	ATXN2	No	-	2	UBC, TARDBP
VAPB	SIGMAR1	No	-	1	UBC
CHMP2B	MATR3	No	-	1	UBC
CHMP2B	DCTN1	No	-	1	UBC
CHMP2B	OPTN	No	-	1	UBC
CHMP2B	TBK1	No	-	2	UBC, RPS27A
CHMP2B	UBQLN2	No	-	3	UBC, RPS27A, UBB
CHMP2B	ERBB4	No	-	2	UBC, NEDD4L
CHMP2B	SOD1	No	-	2	UBC, SQSTM1
CHMP2B	HNRNPA1	No	-	1	UBC
CHMP2B	VCP	No	-	3	UBC, RPS27A, UBB
CHMP2B	TUBA4A	No	-	1	UBC
CHMP2B	TARDBP	No	-	2	UBC, SQSTM1
CHMP2B	SQSTM1	Yes	binding	4	UBC, UBA52, RPS27A, UBB
CHMP2B	PRPH	No	-	1	UBC
CHMP2B	PFN1	No	-	1	UBC
CHMP2B	SPG11	No	-	1	UBC
CHMP2B	ATXN2	No	-	1	UBC
CHMP2B	SIGMAR1	No	-	1	UBC
MATR3	DCTN1	No	-	1	UBC
MATR3	OPTN	No	-	1	UBC
MATR3	TBK1	No	-	1	UBC
MATR3	UBQLN2	No	-	1	UBC
MATR3	ERBB4	No	-	1	UBC
MATR3	SOD1	No	-	1	UBC
MATR3	HNRNPA1	No	-	2	UBC, HNRNPK
MATR3	VCP	No	-	1	UBC
MATR3	TUBA4A	No	-	1	UBC
MATR3	TARDBP	No	-	1	UBC
MATR3	SQSTM1	No	-	1	UBC
MATR3	PRPH	No	-	1	UBC
MATR3	PFN1	No	-	1	UBC
MATR3	SPG11	No	-	1	UBC
MATR3	ATXN2	No	-	1	UBC
MATR3	SIGMAR1	No	-	1	UBC
DCTN1	OPTN	No	-	1	UBC
DCTN1	TBK1	No	-	2	UBC, PTPN11
DCTN1	UBQLN2	No	-	1	UBC
DCTN1	ERBB4	No	-	3	UBC, PTPN11, GRB2
DCTN1	SOD1	No	-	2	UBC, POTEI
DCTN1	HNRNPA1	No	-	1	UBC
DCTN1	VCP	No	-	1	UBC
DCTN1	TUBA4A	No	-	21	DYNC1LI2, MAPRE3, DYNC2H1, DNAH9, PAFAH1B1, DCTN2, CLIP1, DCTN3, DYNLL1, GJA1, DNAH11, DYNC1H1, MAPRE1, UBC, DYNC1I2, DYNC1I1, DNAH17, DYNC1LI1, POTEI, ACTR1A, RILP
DCTN1	TARDBP	No	-	1	UBC
DCTN1	SQSTM1	No	-	1	UBC
DCTN1	PRPH	No	-	1	UBC
DCTN1	PFN1	No	-	20	ACTBL2, POTEF, ACTA2, ACTRT1, ACTA1, ACTL7B, ACTC1, ACTRT3, ACTL8, ACTL9, ACTRT2, ACTL10, ACTG2, ACTR1B, UBC, POTEI, ACTR1A, POTEJ, ACTL7A, ACTR10
DCTN1	SPG11	No	-	1	UBC
DCTN1	ATXN2	No	-	1	UBC
DCTN1	SIGMAR1	No	-	1	UBC
OPTN	TBK1	Yes	binding	3	UBC, TAX1BP1, CYLD
OPTN	UBQLN2	No	-	1	UBC
OPTN	ERBB4	No	-	1	UBC
OPTN	SOD1	Yes	binding	1	UBC
OPTN	HNRNPA1	No	-	1	UBC
OPTN	VCP	No	-	3	HTT, UBC, MAP1LC3A
OPTN	TUBA4A	No	-	3	UBC, SOD1, PLK1
OPTN	TARDBP	No	-	2	UBC, SOD1
OPTN	SQSTM1	No	-	8	MAP1LC3B, SOD1, HTT, CYLD, RIPK1, MAP1LC3A, UBC, GABARAPL1
OPTN	PRPH	No	-	1	UBC
OPTN	PFN1	No	-	1	UBC
OPTN	SPG11	No	-	1	UBC
OPTN	ATXN2	No	-	1	UBC
OPTN	SIGMAR1	No	-	1	UBC
TBK1	UBQLN2	No	-	2	UBC, RPS27A
TBK1	ERBB4	No	-	4	UBC, PTPN11, TRAF6, HSP90AA1
TBK1	SOD1	No	-	2	UBC, OPTN
TBK1	HNRNPA1	No	-	1	UBC
TBK1	VCP	No	-	3	UBC, RPS27A, HSP90AA1
TBK1	TUBA4A	No	-	2	UBC, HSP90AA1
TBK1	TARDBP	No	-	2	UBC, HSP90AA1
TBK1	SQSTM1	No	-	8	RPS27A, RELA, CALCOCO2, MTOR, CYLD, TRAF6, TRAF2, UBC
TBK1	PRPH	No	-	1	UBC
TBK1	PFN1	No	-	1	UBC
TBK1	SPG11	No	-	1	UBC
TBK1	ATXN2	No	-	1	UBC
TBK1	SIGMAR1	No	-	1	UBC
UBQLN2	ERBB4	No	-	2	EPS15, UBC
UBQLN2	SOD1	No	-	2	UBC, TARDBP
UBQLN2	HNRNPA1	No	-	2	UBC, TARDBP
UBQLN2	VCP	Yes	binding	12	PSMD4, UFD1L, RPS27A, UBOX5, TARDBP, RAD23A, NPLOC4, RAD23B, UBC, FAF2, UBE4B, UBB
UBQLN2	TUBA4A	No	-	1	UBC
UBQLN2	TARDBP	Yes	activation, binding	2	UBC, VCP
UBQLN2	SQSTM1	No	-	4	UBC, RPS27A, UBB, TARDBP
UBQLN2	PRPH	No	-	1	UBC
UBQLN2	PFN1	No	-	1	UBC
UBQLN2	SPG11	No	-	1	UBC
UBQLN2	ATXN2	No	-	2	UBC, TARDBP
UBQLN2	SIGMAR1	No	-	1	UBC
NEFH	HNRNPA1	No	-	1	MAPK14
NEFH	VCP	No	-	1	CDK1
NEFH	TUBA4A	No	-	1	CDK1
NEFH	SQSTM1	No	-	2	MAPK14, CDK1
NEFH	PRPH	Yes	binding, ptmod	1	NEFM
NEFH	ATXN2	No	-	1	CDK5
ERBB4	SOD1	No	-	1	UBC
ERBB4	HNRNPA1	No	-	2	UBC, CTNNB1
ERBB4	VCP	No	-	2	UBC, HSP90AA1
ERBB4	TUBA4A	No	-	2	UBC, HSP90AA1
ERBB4	TARDBP	No	-	2	UBC, HSP90AA1
ERBB4	SQSTM1	No	-	3	UBC, TRAF6, TP53
ERBB4	PRPH	No	-	1	UBC
ERBB4	PFN1	No	-	1	UBC
ERBB4	SPG11	No	-	1	UBC
ERBB4	ATXN2	No	-	3	UBC, SH3GL3, SH3GL2
ERBB4	SIGMAR1	No	-	1	UBC
SOD1	HNRNPA1	No	-	4	UBC, PCBP1, TARDBP, AKT1
SOD1	VCP	No	-	8	DERL1, HSPA8, TARDBP, RNF19A, HSPA4, AKT1, UBC, STUB1
SOD1	TUBA4A	Yes	reaction, binding	10	HABP4, TTN, WDR1, VCL, PLEK, ESR1, UBC, BRPF3, POTEI, TLN1
SOD1	TARDBP	Yes	activation, binding	4	UBC, PCBP1, HSPA4, SQSTM1
SOD1	SQSTM1	Yes	binding	4	UBC, TARDBP, BCL2, STUB1
SOD1	PRPH	No	-	1	UBC
SOD1	PFN1	No	-	3	UBC, POTEI, VCL
SOD1	SPG11	No	-	1	UBC
SOD1	ATXN2	No	-	2	UBC, TARDBP
SOD1	SIGMAR1	No	-	1	UBC
HNRNPA1	VCP	No	-	3	UBC, TARDBP, AKT1
HNRNPA1	TUBA4A	No	-	1	UBC
HNRNPA1	TARDBP	Yes	activation, binding	8	HNRNPA2B1, BCL2L1, SNRPB2, FUS, PCBP1, HNRNPR, SYNCRIP, UBC
HNRNPA1	SQSTM1	No	-	3	UBC, MAPK14, TARDBP
HNRNPA1	PRPH	No	-	1	UBC
HNRNPA1	PFN1	No	-	1	UBC
HNRNPA1	C9orf72	Yes	binding	0
HNRNPA1	SPG11	No	-	1	UBC
HNRNPA1	ATXN2	No	-	4	FUS, UBC, TARDBP, PABPC1
HNRNPA1	SIGMAR1	No	-	1	UBC
VCP	TUBA4A	No	-	5	PPP2R1A, UBC, CDK1, CCT2, HSP90AA1
VCP	TARDBP	Yes	activation, binding	7	UBQLN2, HSPA4, VAPB, UBQLN1, HSP90AA1, UBC, SUMO2
VCP	SQSTM1	No	-	8	RPS27A, TARDBP, HTT, CDK1, MAP1LC3A, UBC, UBB, STUB1
VCP	PRPH	No	-	1	UBC
VCP	PFN1	No	-	1	UBC
VCP	SPG11	No	-	1	UBC
VCP	ATXN2	No	-	2	UBC, TARDBP
VCP	SIGMAR1	No	-	1	UBC
TUBA4A	TARDBP	No	-	3	UBC, SOD1, HSP90AA1
TUBA4A	SQSTM1	No	-	3	UBC, CDK1, SOD1
TUBA4A	PRPH	No	-	1	UBC
TUBA4A	PFN1	No	-	4	UBC, ACTR1A, POTEI, VCL
TUBA4A	SPG11	No	-	1	UBC
TUBA4A	ATXN2	No	-	1	UBC
TUBA4A	SIGMAR1	No	-	1	UBC
TARDBP	SQSTM1	Yes	activation, binding	2	UBC, SOD1
TARDBP	PRPH	No	-	1	UBC
TARDBP	PFN1	No	-	1	UBC
TARDBP	C9orf72	No	-	1	HNRNPA1
TARDBP	SPG11	No	-	1	UBC
TARDBP	ATXN2	Yes	activation, binding	2	FUS, UBC
TARDBP	SIGMAR1	No	-	1	UBC
SQSTM1	PRPH	No	-	1	UBC
SQSTM1	PFN1	No	-	2	UBC, DVL2
SQSTM1	SPG11	No	-	1	UBC
SQSTM1	ATXN2	No	-	2	UBC, TARDBP
SQSTM1	SIGMAR1	No	-	1	UBC
PRPH	PFN1	No	-	1	UBC
PRPH	SPG11	No	-	1	UBC
PRPH	ATXN2	No	-	1	UBC
PRPH	SIGMAR1	No	-	1	UBC
PFN1	SPG11	No	-	1	UBC
PFN1	ATXN2	No	-	1	UBC
PFN1	SIGMAR1	No	-	1	UBC
SPG11	ATXN2	No	-	1	UBC
SPG11	SIGMAR1	No	-	1	UBC
ATXN2	SIGMAR1	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
FUS	MATR3	No	-	2	HNRNPU, HSPA5
FUS	HNRNPA1	No	-	11	DDX5, RALY, HNRNPM, HNRNPR, DHX9, SRPK1, HNRNPU, HNRNPH1, ILF2, ILF3, NCL
FUS	TARDBP	Yes	Large Drosha complex	18	HNRNPH1, DDX5, SRPK1, RALY, DDX17, DDX3X, HNRNPM, HNRNPUL1, HNRNPDL, HNRNPU, ILF2, DHX15, TAF15, DGCR8, EWSR1, ILF3, DDX1, DROSHA
MATR3	HNRNPA1	No	-	8	PRPF8, CDC5L, DDX23, HNRNPU, SNRNP200, SNW1, EEF1A1, EFTUD2
MATR3	TUBA4A	No	-	1	TUBB
MATR3	TARDBP	No	-	1	HNRNPU
HNRNPA1	TARDBP	No	-	8	DDX5, RALY, HNRNPM, HNRNPU, SRPK1, HNRNPH1, ILF3, ILF2
VCP	PFN1	Yes	Profilin 1 complex	4	ACTG1, CLTC, HSPA8, TUBB2B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
FUS	DCTN1	No	2	DYNC1H1, SAP30BP
DCTN1	TUBA4A	No	1	POLR2B
SOD1	TARDBP	No	1	AHCYL1
HNRNPA1	TARDBP	No	3	SYNCRIP, HNRNPR, HNRNPK
HNRNPA1	SQSTM1	No	1	HNRNPA2B1
HNRNPA1	PRPH	No	1	HNRNPU
VCP	ATXN2	No	1	CCT5
TUBA4A	PRPH	No	1	ILF3
TARDBP	PFN1	No	1	SRPRB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Amyotrophic lateral sclerosis (ALS)	hsa05014	7.01	4	SOD1, NEFH, PRPH, ALS2
Protein processing in endoplasmic reticulum	hsa04141	5.35	2	UBQLN2, VCP
Huntington's disease	hsa05016	5.17	2	DCTN1, SOD1
Endocytosis	hsa04144	4.92	2	CHMP2B, ERBB4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Amyotrophic lateral sclerosis (ALS) (hsa05014)	-	7.01	0.0	SOD1, NEFH, PRPH, ALS2, VCP
Neurodegenerative diseases	NEW	4.27	0.036	SOD1, NEFH, DCTN1, PRPH, ALS2

REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Immune System	R-HSA-168256	2.37	5	TUBA4A, TBK1, DCTN1, ERBB4, SQSTM1
Signal Transduction	R-HSA-162582	1.78	5	ERBB4, TUBA4A, PFN1, VCP, SQSTM1
Disease	R-HSA-1643685	3.33	3	CHMP2B, ERBB4, VCP
Platelet degranulation	R-HSA-114608	6.68	3	TUBA4A, SOD1, PFN1
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.66	3	TUBA4A, DCTN1, OPTN
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	TUBA4A, SOD1, PFN1
Cellular responses to stress	R-HSA-2262752	4.56	3	CHMP2B, SOD1, VCP
Mitotic G2-G2/M phases	R-HSA-453274	6.04	3	TUBA4A, DCTN1, OPTN
Cell Cycle, Mitotic	R-HSA-69278	4.16	3	TUBA4A, DCTN1, OPTN
Developmental Biology	R-HSA-1266738	3.48	3	TUBA4A, PFN1, ERBB4
Cell Cycle	R-HSA-1640170	3.89	3	TUBA4A, DCTN1, OPTN
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	3	TUBA4A, SOD1, PFN1
Axon guidance	R-HSA-422475	3.93	3	TUBA4A, ERBB4, PFN1
Hemostasis	R-HSA-109582	3.98	3	TUBA4A, SOD1, PFN1
Adaptive Immune System	R-HSA-1280218	3.19	3	TUBA4A, DCTN1, ERBB4
G2/M Transition	R-HSA-69275	6.06	3	TUBA4A, DCTN1, OPTN
Signaling by Interleukins	R-HSA-449147	4.71	2	ERBB4, SQSTM1
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.03	2	TUBA4A, DCTN1
Signaling by Rho GTPases	R-HSA-194315	4.43	2	TUBA4A, PFN1
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	ERBB4, SQSTM1
Metabolism	R-HSA-1430728	2.34	2	FIG4, VAPB
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.1	2	FUS, HNRNPA1
Signaling by Hedgehog	R-HSA-5358351	5.79	2	TUBA4A, VCP
Assembly of the primary cilium	R-HSA-5617833	5.44	2	TUBA4A, DCTN1
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	6.68	2	TUBA4A, DCTN1
Signalling by NGF	R-HSA-166520	4.23	2	ERBB4, SQSTM1
Gene Expression	R-HSA-74160	2.72	2	FUS, HNRNPA1
Organelle biogenesis and maintenance	R-HSA-1852241	4.63	2	TUBA4A, DCTN1
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	2	FIG4, VAPB
RHO GTPases Activate Formins	R-HSA-5663220	6.01	2	TUBA4A, PFN1
Diseases of signal transduction	R-HSA-5663202	4.89	2	ERBB4, VCP
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.03	2	TUBA4A, DCTN1
Centrosome maturation	R-HSA-380287	6.68	2	TUBA4A, DCTN1
Innate Immune System	R-HSA-168249	3.17	2	TBK1, ERBB4
Metabolism of proteins	R-HSA-392499	3.41	2	TUBA4A, DCTN1
Membrane Trafficking	R-HSA-199991	5.26	2	CHMP2B, TUBA4A
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.51	2	TUBA4A, DCTN1
Vesicle-mediated transport	R-HSA-5653656	4.33	2	CHMP2B, TUBA4A
RHO GTPase Effectors	R-HSA-195258	4.94	2	TUBA4A, PFN1
mRNA Splicing - Major Pathway	R-HSA-72163	6.15	2	FUS, HNRNPA1
mRNA Splicing	R-HSA-72172	6.15	2	FUS, HNRNPA1
MHC class II antigen presentation	R-HSA-2132295	6.01	2	TUBA4A, DCTN1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	26	HNRNPA1, VCP, MATR3, VAPB, FIG4, SETX, SIGMAR1, TARDBP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHMP2B, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, TUBA4A, SQSTM1, C9orf72, ERBB4
protein binding (GO:0005515)	0.46	25	HNRNPA1, VCP, MATR3, VAPB, FIG4, SETX, TARDBP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHMP2B, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, TUBA4A, SQSTM1, C9orf72, ERBB4
organic cyclic compound binding (GO:0097159)	1.05	12	ATXN2, HNRNPA1, PFN1, VCP, TARDBP, FUS, TBK1, ANG, TUBA4A, ERBB4, MATR3, SETX
heterocyclic compound binding (GO:1901363)	1.06	12	ATXN2, HNRNPA1, PFN1, VCP, TARDBP, FUS, TBK1, ANG, TUBA4A, ERBB4, MATR3, SETX
identical protein binding (GO:0042802)	2.63	11	VCP, SOD1, FUS, SETX, VAPB, ANG, ALS2, OPTN, TARDBP, ERBB4, SQSTM1
nucleic acid binding (GO:0003676)	1.44	11	HNRNPA1, ATXN2, VCP, TARDBP, FUS, TBK1, ANG, PFN1, SETX, MATR3, ERBB4
small molecule binding (GO:0036094)	1.89	10	HNRNPA1, VCP, PFN1, TARDBP, FUS, TBK1, TUBA4A, SETX, MATR3, ERBB4
catalytic activity (GO:0003824)	1.05	10	SETX, SOD1, VCP, TBK1, DCTN1, TUBA4A, ANG, FIG4, SQSTM1, ERBB4
enzyme binding (GO:0019899)	2.27	10	VCP, SOD1, VAPB, PFN1, TUBA4A, SQSTM1, OPTN, C9orf72, NEFH, ALS2
nucleoside phosphate binding (GO:1901265)	1.96	10	HNRNPA1, VCP, PFN1, TARDBP, FUS, TBK1, TUBA4A, SETX, MATR3, ERBB4
nucleotide binding (GO:0000166)	1.96	10	HNRNPA1, VCP, PFN1, TARDBP, FUS, TBK1, TUBA4A, SETX, MATR3, ERBB4
protein dimerization activity (GO:0046983)	2.72	8	SOD1, PRPH, VAPB, ANG, ERBB4, NEFH, ALS2, SQSTM1
RNA binding (GO:0003723)	2.36	8	ATXN2, HNRNPA1, VCP, PFN1, FUS, MATR3, ANG, TARDBP
poly(A) RNA binding (GO:0044822)	2.69	7	VCP, HNRNPA1, PFN1, ATXN2, FUS, MATR3, TARDBP
receptor binding (GO:0005102)	2.43	7	ATXN2, PFN1, VCP, FUS, ANG, SQSTM1, ERBB4
carbohydrate derivative binding (GO:0097367)	2.03	6	VCP, TBK1, ANG, TUBA4A, SETX, ERBB4
purine nucleotide binding (GO:0017076)	2.19	6	VCP, PFN1, TBK1, TUBA4A, SETX, ERBB4
hydrolase activity (GO:0016787)	1.9	6	VCP, DCTN1, TUBA4A, ANG, FIG4, SETX
protein homodimerization activity (GO:0042803)	3.16	6	SOD1, VAPB, ANG, ERBB4, ALS2, SQSTM1
DNA binding (GO:0003677)	1.92	6	HNRNPA1, TARDBP, FUS, ANG, ERBB4, SETX
cation binding (GO:0043169)	1.4	5	ANG, FUS, MATR3, SOD1, SQSTM1
adenyl nucleotide binding (GO:0030554)	2.4	5	ERBB4, SETX, TBK1, PFN1, VCP
transition metal ion binding (GO:0046914)	2.48	5	ANG, FUS, MATR3, SOD1, SQSTM1
cytoskeletal protein binding (GO:0008092)	3.02	5	ANG, FUS, NEFH, VAPB, PFN1
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	5	ERBB4, TUBA4A, TBK1, SETX, VCP
ion binding (GO:0043167)	1.36	5	ANG, FUS, MATR3, SOD1, SQSTM1
Ras GTPase binding (GO:0017016)	4.2	5	C9orf72, OPTN, SOD1, PFN1, ALS2
small GTPase binding (GO:0031267)	4.13	5	SOD1, C9orf72, ALS2, OPTN, PFN1
GTPase binding (GO:0051020)	4.05	5	C9orf72, ALS2, SOD1, OPTN, PFN1
purine nucleoside binding (GO:0001883)	2.22	5	ERBB4, TUBA4A, TBK1, SETX, VCP
ribonucleoside binding (GO:0032549)	2.22	5	ERBB4, TUBA4A, TBK1, SETX, VCP
purine ribonucleotide binding (GO:0032555)	2.2	5	ERBB4, TUBA4A, TBK1, SETX, VCP
metal ion binding (GO:0046872)	1.41	5	ANG, FUS, MATR3, SOD1, SQSTM1
purine ribonucleoside binding (GO:0032550)	2.22	5	ERBB4, TUBA4A, TBK1, SETX, VCP
ribonucleotide binding (GO:0032553)	2.19	5	ERBB4, TUBA4A, TBK1, SETX, VCP
nucleoside binding (GO:0001882)	2.21	5	ERBB4, TUBA4A, TBK1, SETX, VCP
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	4	TUBA4A, DCTN1, SETX, VCP
nucleoside-triphosphatase activity (GO:0017111)	3.09	4	TUBA4A, DCTN1, SETX, VCP
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	4	TUBA4A, DCTN1, SETX, VCP
structural molecule activity (GO:0005198)	3.1	4	TUBA4A, NEFH, MATR3, PRPH
pyrophosphatase activity (GO:0016462)	3.04	4	TUBA4A, DCTN1, SETX, VCP
adenyl ribonucleotide binding (GO:0032559)	2.41	4	ERBB4, TBK1, SETX, VCP
zinc ion binding (GO:0008270)	2.66	4	FUS, MATR3, SOD1, SQSTM1
molecular function regulator (GO:0098772)	2.51	4	ERBB4, ALS2, PFN1, VCP
ATP binding (GO:0005524)	2.43	4	ERBB4, TBK1, SETX, VCP
protein domain specific binding (GO:0019904)	3.32	4	VAPB, CHMP2B, SQSTM1, VCP
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	TBK1, ERBB4, SQSTM1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	TBK1, ERBB4, SQSTM1
enzyme regulator activity (GO:0030234)	2.85	3	ALS2, PFN1, VCP
kinase activity (GO:0016301)	2.93	3	TBK1, ERBB4, SQSTM1
ubiquitin-like protein binding (GO:0032182)	4.93	3	OPTN, SQSTM1, VCP
Rab GTPase binding (GO:0017137)	4.96	3	C9orf72, ALS2, OPTN
transferase activity (GO:0016740)	1.95	3	TBK1, ERBB4, SQSTM1
ubiquitin binding (GO:0043130)	5.09	3	OPTN, SQSTM1, VCP
protein kinase activity (GO:0004672)	3.27	3	TBK1, ERBB4, SQSTM1
protein heterodimerization activity (GO:0046982)	3.64	3	NEFH, PRPH, VAPB
polyubiquitin binding (GO:0031593)	5.98	3	OPTN, SQSTM1, VCP
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	ERBB4, ALS2
protein C-terminus binding (GO:0008022)	4.5	2	ATXN2, OPTN
structural constituent of cytoskeleton (GO:0005200)	5.12	2	TUBA4A, NEFH
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	SQSTM1, VCP
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	ERBB4, ALS2
Rho GTPase binding (GO:0017048)	5.36	2	SOD1, PFN1
molecular transducer activity (GO:0060089)	2.32	2	SIGMAR1, ERBB4
receptor activity (GO:0004872)	2.32	2	SIGMAR1, ERBB4
signal transducer activity (GO:0004871)	2.28	2	SIGMAR1, ERBB4
signaling receptor activity (GO:0038023)	2.49	2	SIGMAR1, ERBB4
sequence-specific DNA binding (GO:0043565)	2.79	2	HNRNPA1, SETX
dynein binding (GO:0045502)	6.44	2	NEFH, DCTN1
actin binding (GO:0003779)	3.74	2	ANG, PFN1
protein serine/threonine kinase activity (GO:0004674)	3.64	2	TBK1, SQSTM1
K63-linked polyubiquitin binding (GO:0070530)	6.79	2	OPTN, SQSTM1
double-stranded DNA binding (GO:0003690)	3.09	2	TARDBP, SETX
copper ion binding (GO:0005507)	5.71	2	ANG, SOD1
tubulin binding (GO:0015631)	4.1	2	NEFH, VAPB
epidermal growth factor receptor binding (GO:0005154)	6.34	2	ERBB4, ATXN2
microtubule binding (GO:0008017)	4.42	2	NEFH, VAPB
regulatory region nucleic acid binding (GO:0001067)	3.03	2	ERBB4, SETX
lipid binding (GO:0008289)	3.26	2	PFN1, VCP
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	2	ANG, FIG4
protein kinase binding (GO:0019901)	3.44	2	NEFH, SQSTM1
kinase binding (GO:0019900)	3.32	2	NEFH, SQSTM1
protein phosphatase binding (GO:0019903)	4.93	2	SOD1, VCP
phosphatase binding (GO:0019902)	4.63	2	SOD1, VCP
binding, bridging (GO:0060090)	4.57	2	NEFH, OPTN
transcription regulatory region DNA binding (GO:0044212)	3.03	2	ERBB4, SETX
protein binding, bridging (GO:0030674)	4.68	2	NEFH, OPTN
ubiquitin protein ligase binding (GO:0031625)	4.17	2	SQSTM1, VCP
growth factor receptor binding (GO:0070851)	4.87	2	ERBB4, ATXN2
transmembrane signaling receptor activity (GO:0004888)	2.57	2	SIGMAR1, ERBB4
regulatory region DNA binding (GO:0000975)	3.03	2	ERBB4, SETX
transmembrane receptor activity (GO:0099600)	2.53	2	SIGMAR1, ERBB4
enzyme activator activity (GO:0008047)	3.56	2	ALS2, VCP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
poly(A) RNA binding (GO:0044822)	-	2.69	0.034	ATXN2, HNRNPA1, SOD1, VCP, FUS, MATR3, DCTN1, PFN1, SQSTM1, TARDBP, SETX
tubulin binding (GO:0015631)	-	4.1	0.014	TBK1, DCTN1, VAPB, TUBA4A, OPTN, NEFH, SQSTM1
structural constituent of cytoskeleton (GO:0005200)	-	5.12	0.04	TUBA4A, DCTN1, NEFH, PRPH
cytoskeletal protein binding (GO:0008092)	-	3.02	0.001	ATXN2, VCP, SOD1, TBK1, DCTN1, VAPB, ANG, PFN1, TUBA4A, SQSTM1, OPTN, NEFH, ERBB4
microtubule binding (GO:0008017)	-	4.42	0.009	TBK1, DCTN1, TUBA4A, OPTN, NEFH, SQSTM1
small conjugating protein binding (GO:0032182)	-	4.93	0.045	OPTN, SQSTM1, VCP
Rab GTPase binding (GO:0017137)	-	4.96	0.042	C9orf72, ALS2, OPTN
enzyme binding (GO:0019899)	-	2.27	0.012	ATXN2, HNRNPA1, VCP, SOD1, FUS, ALS2, DCTN1, VAPB, PFN1, TUBA4A, SQSTM1, OPTN, C9orf72, NEFH, ERBB4
Ras GTPase binding (GO:0017016)	-	4.2	0.001	HNRNPA1, SOD1, PFN1, OPTN, C9orf72, ALS2
small GTPase binding (GO:0031267)	-	4.13	0.002	HNRNPA1, SOD1, PFN1, OPTN, C9orf72, ALS2
GTPase binding (GO:0051020)	-	4.05	0.003	HNRNPA1, SOD1, PFN1, OPTN, C9orf72, ALS2
ubiquitin binding (GO:0043130)	-	5.09	0.028	OPTN, SQSTM1, VCP
RNA binding (GO:0003723)	-	2.36	0.033	ATXN2, HNRNPA1, VCP, SOD1, TARDBP, FUS, TBK1, DCTN1, ANG, PFN1, SETX, MATR3, SQSTM1
protein binding (GO:0005515)	-	0.46	0.01	HNRNPA1, VCP, MATR3, VAPB, FIG4, TARDBP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHMP2B, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, TUBA4A, SQSTM1, C9orf72, ERBB4
polyubiquitin binding (GO:0031593)	-	5.98	0.007	OPTN, SQSTM1, VCP
dynein binding (GO:0045502)	-	6.44	0.002	NEFH, DCTN1, VCP
identical protein binding (GO:0042802)	-	2.63	0.02	VCP, SOD1, FUS, TARDBP, VAPB, ERBB4, ALS2, SQSTM1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	25	HNRNPA1, VCP, TARDBP, VAPB, FIG4, TUBA4A, SETX, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
biological regulation (GO:0065007)	0.39	23	VCP, HNRNPA1, TARDBP, MATR3, VAPB, FIG4, SETX, SIGMAR1, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, NEFH, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, ERBB4
regulation of biological process (GO:0050789)	0.45	22	HNRNPA1, VCP, MATR3, VAPB, FIG4, SETX, SIGMAR1, TARDBP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHMP2B, NEFH, UBQLN2, ATXN2, FUS, TBK1, SQSTM1, ERBB4
single-organism process (GO:0044699)	0.48	21	SETX, ANG, VCP, SOD1, VAPB, TBK1, ALS2, DCTN1, FIG4, PRPH, PFN1, CHMP2B, SIGMAR1, ERBB4, OPTN, TUBA4A, NEFH, CHCHD10, SPG11, TARDBP, SQSTM1
regulation of cellular process (GO:0050794)	0.5	21	SIGMAR1, ATXN2, UBQLN2, HNRNPA1, VCP, SOD1, FUS, TBK1, ALS2, DCTN1, FIG4, VAPB, ANG, PFN1, CHMP2B, SETX, OPTN, NEFH, TARDBP, ERBB4, SQSTM1
single-organism cellular process (GO:0044763)	0.65	20	SETX, ANG, VCP, SOD1, TBK1, ALS2, DCTN1, FIG4, VAPB, PFN1, CHMP2B, SQSTM1, OPTN, PRPH, TUBA4A, NEFH, CHCHD10, SPG11, TARDBP, ERBB4
cellular component organization (GO:0016043)	1.24	18	ATXN2, VCP, SOD1, VAPB, TARDBP, DCTN1, FIG4, PRPH, ANG, PFN1, CHMP2B, ALS2, OPTN, ERBB4, NEFH, CHCHD10, SETX, SQSTM1
cellular component organization or biogenesis (GO:0071840)	1.22	18	ANG, VCP, SOD1, TARDBP, ALS2, DCTN1, CHMP2B, PRPH, PFN1, VAPB, ATXN2, SETX, OPTN, NEFH, CHCHD10, FIG4, ERBB4, SQSTM1
regulation of macromolecule metabolic process (GO:0060255)	1.08	17	SETX, ANG, UBQLN2, HNRNPA1, ATXN2, SOD1, TARDBP, FUS, TBK1, VCP, VAPB, PFN1, ALS2, OPTN, ERBB4, MATR3, SQSTM1
regulation of metabolic process (GO:0019222)	1.02	17	SETX, ANG, UBQLN2, HNRNPA1, ATXN2, SOD1, TARDBP, FUS, TBK1, VCP, VAPB, PFN1, ALS2, OPTN, ERBB4, MATR3, SQSTM1
organic substance metabolic process (GO:0071704)	0.63	16	SETX, UBQLN2, HNRNPA1, ATXN2, SOD1, FUS, TBK1, VCP, VAPB, ANG, FIG4, ALS2, ERBB4, CHCHD10, TARDBP, SQSTM1
regulation of cellular metabolic process (GO:0031323)	1.07	16	SETX, UBQLN2, HNRNPA1, ATXN2, SOD1, FUS, TBK1, ALS2, VCP, VAPB, ANG, PFN1, SQSTM1, OPTN, TARDBP, ERBB4
metabolic process (GO:0008152)	0.58	16	ATXN2, UBQLN2, HNRNPA1, VCP, SOD1, TARDBP, FUS, SETX, ALS2, CHCHD10, VAPB, ANG, FIG4, SQSTM1, TBK1, ERBB4
cellular metabolic process (GO:0044237)	0.69	16	SETX, UBQLN2, HNRNPA1, ATXN2, SOD1, FUS, TBK1, VCP, VAPB, ANG, CHCHD10, ALS2, ERBB4, FIG4, TARDBP, SQSTM1
organelle organization (GO:0006996)	2.02	15	ATXN2, PFN1, SOD1, ALS2, DCTN1, CHMP2B, PRPH, VAPB, SETX, OPTN, NEFH, CHCHD10, FIG4, ERBB4, SQSTM1
regulation of primary metabolic process (GO:0080090)	1.08	15	SETX, UBQLN2, HNRNPA1, ATXN2, SOD1, FUS, TBK1, VCP, VAPB, ANG, PFN1, ALS2, ERBB4, TARDBP, SQSTM1
transport (GO:0006810)	1.51	15	SIGMAR1, ATXN2, HNRNPA1, VCP, SOD1, ALS2, DCTN1, TUBA4A, VAPB, CHMP2B, SQSTM1, OPTN, C9orf72, SPG11, ERBB4
positive regulation of biological process (GO:0048518)	1.2	15	SETX, UBQLN2, HNRNPA1, VCP, SOD1, TBK1, ALS2, FIG4, VAPB, ANG, PFN1, CHMP2B, SQSTM1, TARDBP, ERBB4
establishment of localization (GO:0051234)	1.48	15	SIGMAR1, ATXN2, HNRNPA1, VCP, SOD1, DCTN1, TUBA4A, VAPB, CHMP2B, ERBB4, OPTN, C9orf72, SPG11, ALS2, SQSTM1
localization (GO:0051179)	1.4	15	SIGMAR1, ATXN2, HNRNPA1, VCP, SOD1, DCTN1, TUBA4A, VAPB, CHMP2B, ERBB4, OPTN, C9orf72, SPG11, ALS2, SQSTM1
positive regulation of cellular process (GO:0048522)	1.3	15	SETX, UBQLN2, HNRNPA1, VCP, SOD1, TBK1, ALS2, CHMP2B, VAPB, ANG, PFN1, FIG4, SQSTM1, TARDBP, ERBB4
primary metabolic process (GO:0044238)	0.69	14	UBQLN2, HNRNPA1, ATXN2, VCP, TARDBP, FUS, SETX, CHCHD10, VAPB, ANG, FIG4, SQSTM1, TBK1, ERBB4
response to stimulus (GO:0050896)	1.22	14	SETX, ANG, VCP, SOD1, FUS, TBK1, DCTN1, VAPB, PFN1, SQSTM1, OPTN, NEFH, TARDBP, ALS2
negative regulation of biological process (GO:0048519)	1.33	14	SETX, UBQLN2, HNRNPA1, ATXN2, SOD1, TBK1, VAPB, ANG, PFN1, FIG4, SQSTM1, OPTN, TARDBP, ERBB4
positive regulation of cellular metabolic process (GO:0031325)	1.81	13	SETX, UBQLN2, HNRNPA1, VCP, SOD1, TBK1, ALS2, VAPB, ANG, PFN1, SQSTM1, TARDBP, ERBB4
positive regulation of metabolic process (GO:0009893)	1.74	13	SETX, UBQLN2, HNRNPA1, VCP, SOD1, TBK1, ALS2, VAPB, ANG, PFN1, SQSTM1, TARDBP, ERBB4
negative regulation of cellular process (GO:0048523)	1.41	13	UBQLN2, HNRNPA1, SOD1, ATXN2, SETX, VAPB, ANG, PFN1, FIG4, SQSTM1, OPTN, TARDBP, ERBB4
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	13	SETX, UBQLN2, HNRNPA1, VCP, SOD1, TBK1, ALS2, VAPB, ANG, PFN1, SQSTM1, TARDBP, ERBB4
cellular macromolecule metabolic process (GO:0044260)	0.93	12	SETX, UBQLN2, HNRNPA1, VCP, ATXN2, FUS, TBK1, ANG, ALS2, ERBB4, TARDBP, SQSTM1
regulation of biosynthetic process (GO:0009889)	1.37	12	ATXN2, HNRNPA1, VCP, SOD1, FUS, TBK1, ANG, PFN1, ERBB4, TARDBP, SETX, SQSTM1
macromolecule metabolic process (GO:0043170)	0.83	12	SETX, UBQLN2, HNRNPA1, ATXN2, VCP, FUS, TBK1, ALS2, ANG, SQSTM1, TARDBP, ERBB4
response to stress (GO:0006950)	1.8	12	SETX, VCP, SOD1, TBK1, DCTN1, VAPB, ANG, SQSTM1, OPTN, NEFH, TARDBP, ALS2
signal transduction (GO:0007165)	1.28	12	SETX, SIGMAR1, HNRNPA1, PFN1, VCP, TBK1, DCTN1, VAPB, ALS2, OPTN, ERBB4, SQSTM1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	12	SETX, HNRNPA1, VCP, ATXN2, FUS, TBK1, VAPB, ANG, PFN1, SQSTM1, TARDBP, ERBB4
developmental process (GO:0032502)	1.36	11	SIGMAR1, SOD1, PFN1, SETX, DCTN1, ANG, FIG4, ERBB4, NEFH, SPG11, ALS2
regulation of cellular protein metabolic process (GO:0032268)	1.99	11	ATXN2, UBQLN2, VCP, SOD1, TBK1, ALS2, VAPB, ANG, SQSTM1, TARDBP, ERBB4
regulation of cellular biosynthetic process (GO:0031326)	1.38	11	SETX, HNRNPA1, VCP, ATXN2, FUS, TBK1, ANG, PFN1, SQSTM1, TARDBP, ERBB4
regulation of protein metabolic process (GO:0051246)	1.93	11	ATXN2, UBQLN2, VCP, SOD1, TBK1, ALS2, VAPB, ANG, SQSTM1, TARDBP, ERBB4
nitrogen compound metabolic process (GO:0006807)	1.13	11	VCP, HNRNPA1, SOD1, ATXN2, FUS, TARDBP, VAPB, ANG, CHCHD10, SETX, ERBB4
regulation of biological quality (GO:0065008)	1.68	11	HNRNPA1, VCP, SOD1, TARDBP, VAPB, ANG, PFN1, CHMP2B, ERBB4, ALS2, SQSTM1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	10	SETX, HNRNPA1, PFN1, VCP, FUS, TBK1, VAPB, ERBB4, TARDBP, SQSTM1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	10	VCP, HNRNPA1, SOD1, ATXN2, FUS, TARDBP, ANG, CHCHD10, SETX, ERBB4
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	10	SETX, HNRNPA1, PFN1, ATXN2, FUS, TBK1, ANG, ERBB4, TARDBP, SQSTM1
regulation of phosphorylation (GO:0042325)	2.5	9	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, TARDBP, ALS2, SQSTM1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	9	HNRNPA1, ATXN2, VCP, FUS, TARDBP, ANG, CHCHD10, SETX, ERBB4
cellular response to stimulus (GO:0051716)	1.97	9	VCP, PFN1, FUS, DCTN1, TARDBP, SOD1, VAPB, NEFH, SETX
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	9	SETX, HNRNPA1, PFN1, VCP, TBK1, VAPB, SQSTM1, TARDBP, ERBB4
vesicle-mediated transport (GO:0016192)	2.72	9	VCP, SOD1, DCTN1, TUBA4A, VAPB, CHMP2B, OPTN, C9orf72, SPG11
cellular biosynthetic process (GO:0044249)	1.37	9	SOD1, VCP, TARDBP, CHCHD10, VAPB, ANG, FIG4, SETX, ERBB4
cellular aromatic compound metabolic process (GO:0006725)	1.3	9	HNRNPA1, ATXN2, VCP, FUS, TARDBP, ANG, CHCHD10, ERBB4, SETX
anatomical structure development (GO:0048856)	1.58	9	SIGMAR1, SOD1, SETX, DCTN1, ANG, FIG4, ERBB4, NEFH, ALS2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	9	SETX, HNRNPA1, PFN1, ATXN2, TBK1, ANG, SQSTM1, TARDBP, ERBB4
positive regulation of protein metabolic process (GO:0051247)	2.43	9	UBQLN2, VCP, SOD1, TBK1, ALS2, VAPB, ANG, SQSTM1, ERBB4
regulation of cellular component organization (GO:0051128)	2.01	9	ATXN2, UBQLN2, HNRNPA1, PFN1, VCP, FIG4, CHMP2B, SQSTM1, SETX
regulation of phosphorus metabolic process (GO:0051174)	2.35	9	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, TARDBP, ALS2, SQSTM1
regulation of protein modification process (GO:0031399)	2.32	9	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, TARDBP, ALS2, SQSTM1
biosynthetic process (GO:0009058)	1.32	9	SOD1, VCP, TARDBP, CHCHD10, VAPB, ANG, FIG4, SETX, ERBB4
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	9	UBQLN2, VCP, SOD1, TBK1, ALS2, VAPB, ANG, SQSTM1, ERBB4
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	9	SETX, HNRNPA1, PFN1, VCP, TBK1, VAPB, SQSTM1, TARDBP, ERBB4
regulation of phosphate metabolic process (GO:0019220)	2.35	9	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, TARDBP, ALS2, SQSTM1
regulation of gene expression (GO:0010468)	1.37	9	SETX, PFN1, ATXN2, TARDBP, TBK1, ANG, SQSTM1, MATR3, ERBB4
organic cyclic compound metabolic process (GO:1901360)	1.26	9	HNRNPA1, ATXN2, VCP, FUS, TARDBP, ANG, CHCHD10, ERBB4, SETX
heterocycle metabolic process (GO:0046483)	1.31	9	HNRNPA1, ATXN2, VCP, FUS, TARDBP, ANG, CHCHD10, SETX, ERBB4
cellular component assembly (GO:0022607)	2.14	8	VCP, ATXN2, FIG4, ANG, CHMP2B, SETX, NEFH, SQSTM1
negative regulation of metabolic process (GO:0009892)	1.93	8	UBQLN2, HNRNPA1, ATXN2, SOD1, TBK1, ANG, OPTN, TARDBP
positive regulation of biosynthetic process (GO:0009891)	2.29	8	SETX, HNRNPA1, VCP, PFN1, TBK1, SQSTM1, TARDBP, ERBB4
nucleic acid metabolic process (GO:0090304)	1.46	8	HNRNPA1, ATXN2, VCP, FUS, TARDBP, ANG, SETX, ERBB4
regulation of signaling (GO:0023051)	1.72	8	UBQLN2, TARDBP, SOD1, TBK1, ALS2, SQSTM1, OPTN, ERBB4
regulation of cell communication (GO:0010646)	1.73	8	UBQLN2, TARDBP, SOD1, TBK1, ALS2, SQSTM1, OPTN, ERBB4
organic substance biosynthetic process (GO:1901576)	1.34	8	TARDBP, VCP, FIG4, VAPB, ANG, CHCHD10, SETX, ERBB4
single-organism metabolic process (GO:0044710)	1.63	8	SOD1, VCP, CHCHD10, VAPB, ANG, FIG4, SETX, ERBB4
cellular developmental process (GO:0048869)	1.82	8	SOD1, SETX, ANG, FIG4, ERBB4, NEFH, ALS2, SQSTM1
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	8	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, ALS2, SQSTM1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	8	SETX, HNRNPA1, VCP, PFN1, TBK1, SQSTM1, TARDBP, ERBB4
regulation of molecular function (GO:0065009)	1.78	8	VCP, SOD1, VAPB, ANG, PFN1, CHCHD10, ERBB4, ALS2
cellular localization (GO:0051641)	2.32	8	HNRNPA1, VCP, SOD1, DCTN1, VAPB, CHMP2B, OPTN, SPG11
positive regulation of phosphate metabolic process (GO:0045937)	2.78	8	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, ALS2, SQSTM1
regulation of catalytic activity (GO:0050790)	1.97	8	VCP, SOD1, VAPB, ANG, PFN1, CHCHD10, ERBB4, ALS2
single-organism developmental process (GO:0044767)	1.49	8	SOD1, PFN1, ANG, FIG4, ERBB4, NEFH, SPG11, ALS2
single-organism transport (GO:0044765)	2.18	8	SIGMAR1, SOD1, DCTN1, CHMP2B, TUBA4A, OPTN, SPG11, ERBB4
establishment of localization in cell (GO:0051649)	2.47	8	HNRNPA1, VCP, SOD1, DCTN1, VAPB, CHMP2B, OPTN, SPG11
response to chemical (GO:0042221)	1.98	8	SOD1, VCP, FUS, VAPB, ANG, PFN1, NEFH, SETX
single-organism localization (GO:1902578)	2.09	8	SIGMAR1, SOD1, DCTN1, CHMP2B, TUBA4A, OPTN, SPG11, ERBB4
multi-organism process (GO:0051704)	2.65	8	HNRNPA1, TARDBP, VCP, TBK1, VAPB, ANG, CHMP2B, OPTN
positive regulation of phosphorylation (GO:0042327)	2.9	8	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, ALS2, SQSTM1
regulation of protein phosphorylation (GO:0001932)	2.57	8	TARDBP, SOD1, TBK1, VAPB, ANG, ERBB4, ALS2, SQSTM1
positive regulation of protein modification process (GO:0031401)	2.7	8	VCP, SOD1, TBK1, VAPB, ANG, ERBB4, ALS2, SQSTM1
regulation of RNA metabolic process (GO:0051252)	1.52	8	SETX, TARDBP, PFN1, FUS, TBK1, VAPB, SQSTM1, ERBB4
RNA metabolic process (GO:0016070)	1.59	7	HNRNPA1, TARDBP, ATXN2, FUS, ANG, ERBB4, SETX
regulation of hydrolase activity (GO:0051336)	2.53	7	VCP, SOD1, VAPB, ANG, PFN1, ERBB4, ALS2
regulation of cell death (GO:0010941)	2.43	7	SIGMAR1, VCP, SOD1, TBK1, ERBB4, SETX, SQSTM1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	7	UBQLN2, HNRNPA1, TARDBP, ATXN2, TBK1, ANG, OPTN
cellular response to stress (GO:0033554)	2.51	7	SOD1, VCP, TARDBP, DCTN1, VAPB, NEFH, SETX
intracellular transport (GO:0046907)	2.67	7	HNRNPA1, SOD1, VCP, DCTN1, VAPB, OPTN, SPG11
regulation of signal transduction (GO:0009966)	1.84	7	UBQLN2, SOD1, TBK1, ALS2, SQSTM1, OPTN, ERBB4
phosphorus metabolic process (GO:0006793)	2.15	7	SETX, VCP, TBK1, CHCHD10, FIG4, SQSTM1, ERBB4
regulation of response to stimulus (GO:0048583)	1.54	7	UBQLN2, SOD1, TBK1, ALS2, SQSTM1, OPTN, ERBB4
phosphate-containing compound metabolic process (GO:0006796)	2.16	7	SETX, VCP, TBK1, CHCHD10, FIG4, SQSTM1, ERBB4
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	7	TARDBP, PFN1, FUS, TBK1, SETX, ERBB4, SQSTM1
positive regulation of protein phosphorylation (GO:0001934)	2.95	7	SOD1, TBK1, VAPB, ANG, ERBB4, ALS2, SQSTM1
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	7	HNRNPA1, TARDBP, PFN1, TBK1, ERBB4, SETX, SQSTM1
positive regulation of molecular function (GO:0044093)	2.23	7	VCP, SOD1, VAPB, ANG, PFN1, ERBB4, ALS2
regulation of RNA biosynthetic process (GO:2001141)	1.55	7	SETX, TARDBP, PFN1, FUS, TBK1, SQSTM1, ERBB4
regulation of localization (GO:0032879)	1.94	7	UBQLN2, ATXN2, PFN1, TARDBP, ANG, NEFH, ERBB4
response to organic substance (GO:0010033)	2.2	7	VCP, PFN1, SOD1, VAPB, ANG, NEFH, SETX
positive regulation of catalytic activity (GO:0043085)	2.4	7	VCP, SOD1, VAPB, ANG, PFN1, ERBB4, ALS2
regulation of organelle organization (GO:0033043)	2.72	6	UBQLN2, HNRNPA1, ATXN2, PFN1, CHMP2B, SQSTM1
macromolecular complex subunit organization (GO:0043933)	2.14	6	VCP, ATXN2, ANG, CHMP2B, SETX, SQSTM1
regulation of transport (GO:0051049)	2.24	6	UBQLN2, TARDBP, ATXN2, ANG, NEFH, ERBB4
negative regulation of cellular metabolic process (GO:0031324)	2.01	6	UBQLN2, HNRNPA1, TARDBP, ATXN2, ANG, OPTN
positive regulation of signaling (GO:0023056)	2.41	6	UBQLN2, SOD1, TARDBP, TBK1, ALS2, ERBB4
positive regulation of gene expression (GO:0010628)	2.35	6	TARDBP, PFN1, TBK1, ERBB4, SETX, SQSTM1
positive regulation of cell communication (GO:0010647)	2.41	6	UBQLN2, SOD1, TARDBP, TBK1, ALS2, ERBB4
organic cyclic compound biosynthetic process (GO:1901362)	1.66	6	TARDBP, VCP, ANG, CHCHD10, ERBB4, SETX
positive regulation of hydrolase activity (GO:0051345)	2.91	6	VCP, PFN1, VAPB, ANG, ERBB4, ALS2
regulation of cellular component biogenesis (GO:0044087)	3.08	6	VCP, ATXN2, PFN1, UBQLN2, CHMP2B, SETX
regulation of apoptotic process (GO:0042981)	2.5	6	SIGMAR1, VCP, SOD1, ERBB4, SETX, SQSTM1
positive regulation of multicellular organismal process (GO:0051240)	2.49	6	SOD1, PFN1, TBK1, FIG4, ERBB4, SETX
interspecies interaction between organisms (GO:0044419)	3.08	6	HNRNPA1, TARDBP, VCP, TBK1, VAPB, CHMP2B
regulation of programmed cell death (GO:0043067)	2.49	6	SIGMAR1, VCP, SOD1, ERBB4, SETX, SQSTM1
organic substance transport (GO:0071702)	2.15	6	SIGMAR1, HNRNPA1, VCP, ATXN2, CHMP2B, OPTN
heterocycle biosynthetic process (GO:0018130)	1.7	6	TARDBP, VCP, ANG, CHCHD10, ERBB4, SETX
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	6	TARDBP, PFN1, TBK1, ERBB4, SETX, SQSTM1
multicellular organismal process (GO:0032501)	1.45	6	SOD1, TBK1, ANG, CHMP2B, ERBB4, ALS2
regulation of multi-organism process (GO:0043900)	3.6	6	TARDBP, PFN1, TBK1, VAPB, CHMP2B, SQSTM1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	6	TARDBP, PFN1, TBK1, ERBB4, SETX, SQSTM1
regulation of multicellular organismal process (GO:0051239)	1.87	6	SOD1, PFN1, TBK1, FIG4, ERBB4, SETX
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	6	TARDBP, VCP, ANG, CHCHD10, ERBB4, SETX
regulation of intracellular signal transduction (GO:1902531)	2.31	6	SOD1, TBK1, ALS2, OPTN, ERBB4, SQSTM1
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	6	TARDBP, VCP, ANG, CHCHD10, ERBB4, SETX
protein metabolic process (GO:0019538)	1.45	6	UBQLN2, VCP, TBK1, ERBB4, SETX, SQSTM1
positive regulation of RNA metabolic process (GO:0051254)	2.51	6	TARDBP, PFN1, TBK1, ERBB4, SETX, SQSTM1
regulation of transferase activity (GO:0051338)	2.88	6	SOD1, VAPB, ANG, CHCHD10, ERBB4, ALS2
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	6	TARDBP, PFN1, TBK1, ERBB4, SETX, SQSTM1
regulation of transcription, DNA-templated (GO:0006355)	1.56	6	TARDBP, PFN1, TBK1, ERBB4, SETX, SQSTM1
aromatic compound biosynthetic process (GO:0019438)	1.7	6	TARDBP, VCP, ANG, CHCHD10, ERBB4, SETX
protein localization (GO:0008104)	2.36	5	CHMP2B, ALS2, OPTN, VCP, SQSTM1
positive regulation of kinase activity (GO:0033674)	3.54	5	ANG, ERBB4, SOD1, VAPB, ALS2
phosphorylation (GO:0016310)	2.63	5	ERBB4, CHCHD10, TBK1, SETX, SQSTM1
positive regulation of response to stimulus (GO:0048584)	2.18	5	SOD1, ERBB4, UBQLN2, TBK1, ALS2
movement of cell or subcellular component (GO:0006928)	2.61	5	ANG, SPG11, DCTN1, SOD1, ERBB4
membrane organization (GO:0061024)	3.04	5	VAPB, CHMP2B, OPTN, SOD1, TARDBP
cellular response to chemical stimulus (GO:0070887)	2.57	5	FUS, SETX, NEFH, SOD1, PFN1
intracellular signal transduction (GO:0035556)	2.39	5	SETX, ALS2, TBK1, SQSTM1, ERBB4
cellular protein metabolic process (GO:0044267)	1.63	5	ERBB4, SETX, TBK1, SQSTM1, VCP
positive regulation of transferase activity (GO:0051347)	3.31	5	ANG, ERBB4, SOD1, VAPB, ALS2
positive regulation of signal transduction (GO:0009967)	2.5	5	SOD1, ERBB4, UBQLN2, TBK1, ALS2
regulation of kinase activity (GO:0043549)	3.07	5	ANG, ERBB4, SOD1, VAPB, ALS2
macromolecular complex assembly (GO:0065003)	2.55	5	ANG, ATXN2, SETX, SQSTM1, VCP
protein modification process (GO:0036211)	1.79	5	ERBB4, SETX, TBK1, SQSTM1, VCP
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	5	SETX, TBK1, SQSTM1, PFN1, TARDBP
macromolecule localization (GO:0033036)	2.34	5	CHMP2B, ALS2, OPTN, SQSTM1, VCP
positive regulation of cellular component organization (GO:0051130)	2.68	5	SETX, FIG4, HNRNPA1, PFN1, VCP
regulation of developmental process (GO:0050793)	2.1	5	SOD1, ERBB4, FIG4, SETX, PFN1
autophagy (GO:0006914)	3.82	5	C9orf72, UBQLN2, CHMP2B, OPTN, SQSTM1
cellular protein modification process (GO:0006464)	1.79	5	ERBB4, SETX, TBK1, SQSTM1, VCP
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	3.82	5	VAPB, CHMP2B, SQSTM1, PFN1, TARDBP
macromolecule modification (GO:0043412)	1.73	5	ERBB4, SETX, TBK1, SQSTM1, VCP
multi-organism cellular process (GO:0044764)	3.14	5	CHMP2B, HNRNPA1, VAPB, VCP, TBK1
microtubule-based process (GO:0007017)	3.54	5	SPG11, TUBA4A, DCTN1, NEFH, SOD1
single-multicellular organism process (GO:0044707)	1.78	5	ANG, TBK1, SOD1, ERBB4, ALS2
macromolecule biosynthetic process (GO:0009059)	1.61	5	ANG, ERBB4, TARDBP, SETX, VCP
immune system process (GO:0002376)	2.29	5	ANG, TBK1, DCTN1, SOD1, SQSTM1
single-organism organelle organization (GO:1902589)	2.68	5	PFN1, NEFH, PRPH, SOD1, SQSTM1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	5	SETX, TBK1, SQSTM1, PFN1, TARDBP
regulation of multicellular organismal development (GO:2000026)	2.31	5	SOD1, ERBB4, FIG4, SETX, PFN1
viral process (GO:0016032)	3.15	5	CHMP2B, HNRNPA1, VAPB, VCP, TBK1
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	5	CHMP2B, HNRNPA1, VAPB, VCP, TBK1
RNA biosynthetic process (GO:0032774)	1.84	4	ANG, TARDBP, ERBB4, SETX
negative regulation of biosynthetic process (GO:0009890)	2.47	4	ANG, HNRNPA1, SOD1, TARDBP
cell differentiation (GO:0030154)	2.14	4	ANG, ERBB4, SETX, SQSTM1
negative regulation of cellular component organization (GO:0051129)	3.35	4	UBQLN2, HNRNPA1, ATXN2, PFN1
homeostatic process (GO:0042592)	2.61	4	ANG, CHMP2B, SOD1, VAPB
cell cycle process (GO:0022402)	2.75	4	CHMP2B, DCTN1, TUBA4A, OPTN
cell surface receptor signaling pathway (GO:0007166)	2.09	4	ERBB4, HNRNPA1, SETX, PFN1
cell death (GO:0008219)	3.05	4	ERBB4, ALS2, OPTN, SQSTM1
response to endogenous stimulus (GO:0009719)	2.79	4	ANG, NEFH, SOD1, SETX
single-organism biosynthetic process (GO:0044711)	2.8	4	ANG, CHCHD10, FIG4, VAPB
regulation of viral life cycle (GO:1903900)	4.6	4	CHMP2B, VAPB, PFN1, TARDBP
protein complex subunit organization (GO:0071822)	2.6	4	ANG, CHMP2B, SQSTM1, VCP
posttranscriptional regulation of gene expression (GO:0010608)	3.64	4	ANG, MATR3, TARDBP, ATXN2
negative regulation of multicellular organismal process (GO:0051241)	2.84	4	SOD1, FIG4, TBK1, ERBB4
cellular response to organic substance (GO:0071310)	2.78	4	SOD1, NEFH, SETX, PFN1
negative regulation of apoptotic process (GO:0043066)	3.04	4	SOD1, ERBB4, SETX, SQSTM1
regulation of viral process (GO:0050792)	3.89	4	CHMP2B, VAPB, PFN1, TARDBP
negative regulation of programmed cell death (GO:0043069)	3.02	4	SOD1, ERBB4, SETX, SQSTM1
cytoskeleton organization (GO:0007010)	3.22	4	SOD1, NEFH, PRPH, PFN1
protein phosphorylation (GO:0006468)	2.89	4	ERBB4, TBK1, SETX, SQSTM1
lipid metabolic process (GO:0006629)	2.68	4	ANG, FIG4, ERBB4, VAPB
Golgi vesicle transport (GO:0048193)	4.07	4	VAPB, DCTN1, OPTN, VCP
negative regulation of cell death (GO:0060548)	2.95	4	SOD1, ERBB4, SETX, SQSTM1
regulation of protein kinase activity (GO:0045859)	3.15	4	ANG, SOD1, VAPB, ALS2
defense response (GO:0006952)	2.78	4	ANG, TBK1, ALS2, OPTN
positive regulation of multi-organism process (GO:0043902)	4.68	4	CHMP2B, TBK1, VAPB, PFN1
reproductive process (GO:0022414)	2.55	4	ANG, NEFH, SOD1, SETX
cellular macromolecule biosynthetic process (GO:0034645)	1.66	4	ANG, TARDBP, ERBB4, VCP
mitotic cell cycle process (GO:1903047)	3.12	4	CHMP2B, DCTN1, TUBA4A, OPTN
positive regulation of intracellular signal transduction (GO:1902533)	2.95	4	SOD1, TBK1, ERBB4, ALS2
cellular lipid metabolic process (GO:0044255)	2.92	4	ANG, FIG4, ERBB4, VAPB
response to inorganic substance (GO:0010035)	3.56	4	FUS, NEFH, SOD1, SETX
response to oxidative stress (GO:0006979)	3.9	4	SOD1, NEFH, SETX, ALS2
endosomal transport (GO:0016197)	4.28	4	CHMP2B, DCTN1, ALS2, SQSTM1
animal organ development (GO:0048513)	2.53	4	ANG, NEFH, SOD1, ERBB4
positive regulation of protein kinase activity (GO:0045860)	3.61	4	ANG, SOD1, VAPB, ALS2
organonitrogen compound metabolic process (GO:1901564)	2.32	4	SOD1, CHCHD10, VAPB, VCP
vacuolar transport (GO:0007034)	4.18	4	CHMP2B, DCTN1, ALS2, SQSTM1
response to external stimulus (GO:0009605)	2.55	4	ANG, TBK1, SOD1, OPTN
regulation of cell differentiation (GO:0045595)	2.42	4	SOD1, FIG4, ERBB4, SETX
nervous system development (GO:0007399)	3.53	4	SIGMAR1, DCTN1, ERBB4, SETX
organophosphate metabolic process (GO:0019637)	3.04	4	ERBB4, CHCHD10, FIG4, VCP
system development (GO:0048731)	2.92	4	SIGMAR1, DCTN1, ERBB4, SETX
single-organism cellular localization (GO:1902580)	3.16	4	SPG11, DCTN1, OPTN, SOD1
RNA processing (GO:0006396)	3.01	4	FUS, HNRNPA1, TARDBP, SETX
response to endoplasmic reticulum stress (GO:0034976)	4.46	4	TARDBP, DCTN1, VAPB, VCP
G2/M transition of mitotic cell cycle (GO:0000086)	4.84	3	TUBA4A, DCTN1, OPTN
behavior (GO:0007610)	3.47	3	FIG4, SOD1, ALS2
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	3	HNRNPA1, ERBB4, SETX
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	3	HNRNPA1, ERBB4, SETX
establishment of organelle localization (GO:0051656)	4.15	3	SPG11, CHMP2B, DCTN1
regulation of cell projection organization (GO:0031344)	3.38	3	FIG4, SETX, PFN1
mitochondrion organization (GO:0007005)	3.69	3	CHCHD10, ERBB4, SQSTM1
positive regulation of cell projection organization (GO:0031346)	3.99	3	FIG4, SETX, PFN1
response to external biotic stimulus (GO:0043207)	3.13	3	ANG, TBK1, OPTN
response to bacterium (GO:0009617)	4.18	3	ANG, TBK1, OPTN
peptidyl-amino acid modification (GO:0018193)	2.98	3	TBK1, ERBB4, VCP
rhythmic process (GO:0048511)	4.02	3	ANG, SOD1, SETX
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	3	TBK1, OPTN, SQSTM1
cellular homeostasis (GO:0019725)	3.23	3	CHMP2B, SOD1, VAPB
positive regulation of transport (GO:0051050)	2.9	3	ANG, TARDBP, ERBB4
establishment of protein localization (GO:0045184)	2.53	3	CHMP2B, OPTN, VCP
developmental process involved in reproduction (GO:0003006)	3.36	3	ANG, NEFH, SOD1
establishment of localization by movement along microtubule (GO:0010970)	5.14	3	SPG11, DCTN1, SOD1
glycerolipid metabolic process (GO:0046486)	3.91	3	ANG, FIG4, ERBB4
response to other organism (GO:0051707)	3.48	3	ANG, TBK1, OPTN
single organism signaling (GO:0044700)	3.25	3	SPG11, SOD1, ALS2
single organism reproductive process (GO:0044702)	2.73	3	ANG, SOD1, SETX
response to biotic stimulus (GO:0009607)	3.09	3	ANG, TBK1, OPTN
endoplasmic reticulum unfolded protein response (GO:0030968)	5.07	3	DCTN1, VAPB, VCP
intermediate filament cytoskeleton organization (GO:0045104)	6.04	3	NEFH, SOD1, PRPH
vesicle organization (GO:0016050)	4.13	3	CHMP2B, VAPB, ALS2
intermediate filament-based process (GO:0045103)	6.02	3	NEFH, SOD1, PRPH
negative regulation of gene expression (GO:0010629)	2.48	3	ANG, TBK1, TARDBP
defense response to bacterium (GO:0042742)	4.31	3	ANG, TBK1, OPTN
positive regulation of protein transport (GO:0051222)	3.61	3	ANG, TARDBP, ERBB4
regulation of protein transport (GO:0051223)	3.12	3	ANG, TARDBP, ERBB4
nucleic acid-templated transcription (GO:0097659)	1.91	3	ANG, TARDBP, ERBB4
organic substance catabolic process (GO:1901575)	2.45	3	UBQLN2, SQSTM1, VCP
positive regulation of establishment of protein localization (GO:1904951)	3.49	3	ANG, TARDBP, ERBB4
ER to Golgi vesicle-mediated transport (GO:0006888)	4.7	3	DCTN1, VAPB, VCP
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	3	ANG, FIG4, PFN1
locomotory behavior (GO:0007626)	4.53	3	FIG4, SOD1, ALS2
regulation of establishment of protein localization (GO:0070201)	3.02	3	ANG, TARDBP, ERBB4
negative regulation of multi-organism process (GO:0043901)	4.7	3	TARDBP, VAPB, SQSTM1
single-organism membrane organization (GO:0044802)	3.19	3	TARDBP, OPTN, SOD1
regulation of neuron death (GO:1901214)	4.19	3	SIGMAR1, TBK1, SOD1
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	3	UBQLN2, SQSTM1, VCP
secretion (GO:0046903)	3.38	3	TUBA4A, SOD1, ERBB4
regulation of response to stress (GO:0080134)	2.53	3	UBQLN2, TBK1, SOD1
regulation of nervous system development (GO:0051960)	3.1	3	FIG4, ERBB4, SETX
transcription, DNA-templated (GO:0006351)	1.91	3	ANG, TARDBP, ERBB4
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	ANG, HNRNPA1, TARDBP
cellular catabolic process (GO:0044248)	2.62	3	UBQLN2, VCP, SQSTM1
signaling (GO:0023052)	3.25	3	SPG11, SOD1, ALS2
anatomical structure morphogenesis (GO:0009653)	2.53	3	NEFH, ERBB4, ALS2
regulation of GTPase activity (GO:0043087)	3.21	3	SOD1, ERBB4, ALS2
regulation of protein complex assembly (GO:0043254)	3.83	3	SETX, PFN1, VCP
regulation of protein localization (GO:0032880)	2.88	3	ANG, TARDBP, ERBB4
regulation of neurogenesis (GO:0050767)	3.21	3	FIG4, ERBB4, SETX
positive regulation of viral life cycle (GO:1903902)	5.26	3	CHMP2B, VAPB, PFN1
regulation of cell development (GO:0060284)	3.01	3	FIG4, ERBB4, SETX
cytoskeleton-dependent intracellular transport (GO:0030705)	4.96	3	SPG11, DCTN1, SOD1
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	ANG, HNRNPA1, TARDBP
proteolysis (GO:0006508)	2.73	3	UBQLN2, SQSTM1, VCP
RNA splicing (GO:0008380)	3.85	3	FUS, HNRNPA1, TARDBP
mRNA metabolic process (GO:0016071)	3.33	3	FUS, HNRNPA1, TARDBP
positive regulation of protein complex assembly (GO:0031334)	4.44	3	SETX, PFN1, VCP
defense response to other organism (GO:0098542)	3.75	3	ANG, TBK1, OPTN
vacuole organization (GO:0007033)	4.67	3	CHMP2B, FIG4, ALS2
positive regulation of developmental process (GO:0051094)	2.77	3	FIG4, ERBB4, SETX
cell cycle G2/M phase transition (GO:0044839)	4.82	3	TUBA4A, DCTN1, OPTN
cell projection organization (GO:0030030)	3.14	3	NEFH, SOD1, ALS2
cell cycle phase transition (GO:0044770)	4.24	3	TUBA4A, DCTN1, OPTN
mitotic cell cycle phase transition (GO:0044772)	4.27	3	TUBA4A, DCTN1, OPTN
cellular macromolecular complex assembly (GO:0034622)	3.18	3	ANG, SETX, ATXN2
positive regulation of cell death (GO:0010942)	3.32	3	SOD1, SQSTM1, VCP
modification-dependent macromolecule catabolic process (GO:0043632)	3.69	3	UBQLN2, VCP, SQSTM1
multicellular organism development (GO:0007275)	2.54	3	ANG, ERBB4, ALS2
regulation of growth (GO:0040008)	3.26	3	SOD1, ERBB4, SQSTM1
positive regulation of apoptotic process (GO:0043065)	3.38	3	SOD1, SQSTM1, VCP
ubiquitin-dependent protein catabolic process (GO:0006511)	3.72	3	UBQLN2, SQSTM1, VCP
regulation of organelle assembly (GO:1902115)	4.7	3	UBQLN2, CHMP2B, ATXN2
regulation of autophagy (GO:0010506)	4.21	3	UBQLN2, TBK1, SQSTM1
positive regulation of programmed cell death (GO:0043068)	3.38	3	SOD1, SQSTM1, VCP
regulation of macroautophagy (GO:0016241)	4.98	3	UBQLN2, TBK1, SQSTM1
modification-dependent protein catabolic process (GO:0019941)	3.71	3	UBQLN2, SQSTM1, VCP
protein complex assembly (GO:0006461)	2.78	3	ANG, SQSTM1, VCP
cellular macromolecule catabolic process (GO:0044265)	3.19	3	UBQLN2, SQSTM1, VCP
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	ANG, HNRNPA1, TARDBP
positive regulation of viral process (GO:0048524)	5.11	3	CHMP2B, VAPB, PFN1
cell communication (GO:0007154)	3.04	3	ANG, SPG11, ALS2
cellular response to oxidative stress (GO:0034599)	4.7	3	NEFH, SOD1, SETX
catabolic process (GO:0009056)	2.38	3	UBQLN2, SQSTM1, VCP
macromolecule catabolic process (GO:0009057)	3.0	3	UBQLN2, SQSTM1, VCP
organelle localization (GO:0051640)	3.94	3	DCTN1, CHMP2B, SPG11
lipid biosynthetic process (GO:0008610)	3.49	3	ANG, FIG4, VAPB
response to oxygen-containing compound (GO:1901700)	2.57	3	NEFH, SOD1, SETX
cellular response to oxygen-containing compound (GO:1901701)	3.22	3	NEFH, SOD1, SETX
regulation of cellular component movement (GO:0051270)	3.08	3	NEFH, ERBB4, PFN1
microtubule-based movement (GO:0007018)	4.39	3	SPG11, DCTN1, SOD1
protein transport (GO:0015031)	2.62	3	CHMP2B, OPTN, VCP
single-organism intracellular transport (GO:1902582)	3.59	3	SPG11, DCTN1, SOD1
positive regulation of cellular component biogenesis (GO:0044089)	3.71	3	SETX, PFN1, VCP
mRNA processing (GO:0006397)	3.69	3	FUS, HNRNPA1, TARDBP
positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)	5.47	2	UBQLN2, VCP
regulation of neuron projection development (GO:0010975)	3.69	2	FIG4, SETX
regulation of secretion (GO:0051046)	3.2	2	ANG, TARDBP
positive regulation of secretion (GO:0051047)	3.85	2	ANG, TARDBP
regulation of intracellular transport (GO:0032386)	3.58	2	NEFH, ERBB4
membrane budding (GO:0006900)	6.04	2	CHMP2B, VAPB
purine ribonucleoside monophosphate metabolic process (GO:0009167)	4.7	2	CHCHD10, VCP
plasma membrane organization (GO:0007009)	4.8	2	SOD1, OPTN
regulation of neuron apoptotic process (GO:0043523)	4.47	2	SIGMAR1, SOD1
small molecule metabolic process (GO:0044281)	2.38	2	CHCHD10, VCP
negative regulation of viral life cycle (GO:1903901)	5.27	2	TARDBP, VAPB
ribonucleoside monophosphate metabolic process (GO:0009161)	4.62	2	CHCHD10, VCP
inorganic ion homeostasis (GO:0098771)	3.43	2	SOD1, VAPB
nucleobase-containing compound transport (GO:0015931)	4.42	2	HNRNPA1, ATXN2
negative regulation of receptor-mediated endocytosis (GO:0048261)	6.9	2	UBQLN2, ATXN2
establishment of vesicle localization (GO:0051650)	4.91	2	SPG11, DCTN1
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	ERBB4, SETX
developmental growth (GO:0048589)	4.05	2	SPG11, ERBB4
anatomical structure homeostasis (GO:0060249)	4.25	2	CHMP2B, SOD1
regulation of cytoskeleton organization (GO:0051493)	3.72	2	CHMP2B, PFN1
response to growth factor (GO:0070848)	4.14	2	SETX, PFN1
regulation of neuron differentiation (GO:0045664)	3.39	2	FIG4, SETX
ribonucleoside triphosphate metabolic process (GO:0009199)	4.77	2	CHCHD10, VCP
positive regulation of neuron differentiation (GO:0045666)	3.98	2	FIG4, SETX
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817)	5.27	2	TARDBP, VAPB
placenta development (GO:0001890)	5.99	2	ANG, SOD1
positive regulation of cell development (GO:0010720)	3.57	2	FIG4, SETX
cell part morphogenesis (GO:0032990)	3.99	2	NEFH, ALS2
positive regulation of cellular catabolic process (GO:0031331)	4.15	2	UBQLN2, VCP
regulation of cell proliferation (GO:0042127)	2.41	2	ANG, ERBB4
protein oligomerization (GO:0051259)	3.71	2	SQSTM1, VCP
purine ribonucleoside triphosphate metabolic process (GO:0009205)	4.81	2	CHCHD10, VCP
positive regulation of DNA metabolic process (GO:0051054)	4.49	2	HNRNPA1, PFN1
regulation of DNA metabolic process (GO:0051052)	3.87	2	HNRNPA1, PFN1
negative regulation of transport (GO:0051051)	3.6	2	UBQLN2, ATXN2
DNA repair (GO:0006281)	3.59	2	SETX, VCP
ATP metabolic process (GO:0046034)	4.98	2	CHCHD10, VCP
activation of protein kinase activity (GO:0032147)	4.08	2	ANG, SOD1
defense response to Gram-positive bacterium (GO:0050830)	5.54	2	ANG, TBK1
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	FIG4, ERBB4
positive regulation of neuron projection development (GO:0010976)	4.26	2	FIG4, SETX
response to metal ion (GO:0010038)	3.91	2	FUS, SOD1
interaction with symbiont (GO:0051702)	5.76	2	TARDBP, VAPB
purine ribonucleoside metabolic process (GO:0046128)	4.33	2	CHCHD10, VCP
system process (GO:0003008)	2.3	2	CHMP2B, SOD1
organonitrogen compound biosynthetic process (GO:1901566)	2.85	2	CHCHD10, VAPB
cell motility (GO:0048870)	3.02	2	ANG, ERBB4
response to organonitrogen compound (GO:0010243)	3.2	2	NEFH, SOD1
positive regulation of organelle organization (GO:0010638)	3.38	2	HNRNPA1, PFN1
negative regulation of organelle organization (GO:0010639)	4.07	2	HNRNPA1, PFN1
mRNA splicing, via spliceosome (GO:0000398)	4.27	2	FUS, HNRNPA1
chemical homeostasis (GO:0048878)	2.97	2	SOD1, VAPB
purine nucleotide metabolic process (GO:0006163)	4.09	2	CHCHD10, VCP
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	UBQLN2, ATXN2
anterograde trans-synaptic signaling (GO:0098916)	3.98	2	SPG11, ALS2
DNA metabolic process (GO:0006259)	3.09	2	SETX, VCP
regulation of cellular component size (GO:0032535)	4.21	2	ALS2, PFN1
positive regulation of catabolic process (GO:0009896)	3.94	2	UBQLN2, VCP
regulation of membrane potential (GO:0042391)	3.89	2	SOD1, VCP
regulation of catabolic process (GO:0009894)	3.52	2	UBQLN2, VCP
ovulation cycle process (GO:0022602)	5.25	2	ANG, SOD1
nucleoside triphosphate metabolic process (GO:0009141)	4.61	2	CHCHD10, VCP
purine nucleoside triphosphate metabolic process (GO:0009144)	4.76	2	CHCHD10, VCP
response to reactive oxygen species (GO:0000302)	4.5	2	SOD1, SETX
secretion by cell (GO:0032940)	3.59	2	TUBA4A, SOD1
positive regulation of viral release from host cell (GO:1902188)	7.02	2	CHMP2B, VAPB
nucleoside monophosphate metabolic process (GO:0009123)	4.54	2	CHCHD10, VCP
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	SOD1, ALS2
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	SOD1, ALS2
regulation of protein secretion (GO:0050708)	3.77	2	ANG, TARDBP
positive regulation of GTPase activity (GO:0043547)	3.28	2	ERBB4, ALS2
fibroblast growth factor receptor signaling pathway (GO:0008543)	5.3	2	HNRNPA1, SETX
intracellular protein transport (GO:0006886)	3.2	2	OPTN, VCP
exocytosis (GO:0006887)	4.11	2	TUBA4A, SOD1
axo-dendritic transport (GO:0008088)	6.12	2	SPG11, SOD1
regulated exocytosis (GO:0045055)	4.44	2	TUBA4A, SOD1
regulation of immune system process (GO:0002682)	2.5	2	TBK1, SOD1
ribonucleoprotein complex assembly (GO:0022618)	4.46	2	SETX, ATXN2
positive regulation of proteasomal protein catabolic process (GO:1901800)	5.29	2	UBQLN2, VCP
cell migration (GO:0016477)	3.12	2	ANG, ERBB4
negative regulation of developmental process (GO:0051093)	3.17	2	FIG4, ERBB4
purine ribonucleotide metabolic process (GO:0009150)	4.16	2	CHCHD10, VCP
positive regulation of MAPK cascade (GO:0043410)	3.57	2	SOD1, ERBB4
programmed cell death (GO:0012501)	3.1	2	ERBB4, SQSTM1
immune response (GO:0006955)	2.86	2	ANG, TBK1
establishment of RNA localization (GO:0051236)	4.58	2	HNRNPA1, ATXN2
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	5.05	2	UBQLN2, VCP
organophosphate biosynthetic process (GO:0090407)	3.67	2	CHCHD10, FIG4
double-strand break repair (GO:0006302)	4.73	2	SETX, VCP
positive regulation of cell differentiation (GO:0045597)	3.01	2	FIG4, SETX
RNA transport (GO:0050658)	4.59	2	HNRNPA1, ATXN2
response to hydrogen peroxide (GO:0042542)	5.02	2	SOD1, SETX
response to nitrogen compound (GO:1901698)	3.12	2	NEFH, SOD1
regulation of cellular response to stress (GO:0080135)	3.4	2	UBQLN2, SOD1
proteasomal protein catabolic process (GO:0010498)	4.12	2	UBQLN2, VCP
regulation of anatomical structure size (GO:0090066)	3.78	2	ALS2, PFN1
positive regulation of nervous system development (GO:0051962)	3.64	2	FIG4, SETX
negative regulation of nervous system development (GO:0051961)	4.15	2	FIG4, ERBB4
neuron projection morphogenesis (GO:0048812)	4.34	2	NEFH, ALS2
regulation of cell motility (GO:2000145)	3.16	2	ERBB4, PFN1
negative regulation of receptor internalization (GO:0002091)	7.65	2	UBQLN2, ATXN2
nucleotide metabolic process (GO:0009117)	3.73	2	CHCHD10, VCP
nucleoside phosphate metabolic process (GO:0006753)	3.71	2	CHCHD10, VCP
synaptic signaling (GO:0099536)	3.98	2	SPG11, ALS2
trans-synaptic signaling (GO:0099537)	3.98	2	SPG11, ALS2
regulation of developmental growth (GO:0048638)	4.04	2	SOD1, ERBB4
cellular response to metal ion (GO:0071248)	4.81	2	FUS, SOD1
vesicle localization (GO:0051648)	4.85	2	SPG11, DCTN1
regulation of receptor-mediated endocytosis (GO:0048259)	5.35	2	UBQLN2, ATXN2
MAPK cascade (GO:0000165)	3.91	2	ERBB4, SETX
ion homeostasis (GO:0050801)	3.42	2	SOD1, VAPB
metal ion homeostasis (GO:0055065)	3.61	2	SOD1, VAPB
regulation of Ras protein signal transduction (GO:0046578)	4.49	2	ALS2, SQSTM1
cellular response to inorganic substance (GO:0071241)	4.67	2	FUS, SOD1
response to wounding (GO:0009611)	4.39	2	NEFH, SOD1
regulation of protein catabolic process (GO:0042176)	3.83	2	UBQLN2, VCP
regulation of secretion by cell (GO:1903530)	3.28	2	ANG, TARDBP
ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)	5.62	2	UBQLN2, VCP
positive regulation of secretion by cell (GO:1903532)	3.93	2	ANG, TARDBP
regulation of microtubule-based process (GO:0032886)	4.79	2	CHMP2B, NEFH
purine nucleoside monophosphate metabolic process (GO:0009126)	4.69	2	CHCHD10, VCP
ribonucleotide metabolic process (GO:0009259)	4.11	2	CHCHD10, VCP
response to organic cyclic compound (GO:0014070)	3.07	2	NEFH, SOD1
regulation of MAPK cascade (GO:0043408)	3.22	2	SOD1, ERBB4
negative regulation of protein metabolic process (GO:0051248)	2.82	2	ANG, TARDBP
ovarian follicle development (GO:0001541)	5.82	2	ANG, SOD1
regulation of system process (GO:0044057)	3.53	2	FIG4, SOD1
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)	4.16	2	UBQLN2, VCP
purine nucleoside metabolic process (GO:0042278)	4.32	2	CHCHD10, VCP
regeneration (GO:0031099)	4.7	2	NEFH, ERBB4
modification by host of symbiont morphology or physiology (GO:0051851)	5.8	2	TARDBP, VAPB
positive regulation of neurogenesis (GO:0050769)	3.77	2	FIG4, SETX
chemical synaptic transmission (GO:0007268)	3.98	2	SPG11, ALS2
regulation of viral transcription (GO:0046782)	5.62	2	TARDBP, PFN1
positive regulation of cell proliferation (GO:0008284)	3.01	2	ANG, ERBB4
negative regulation of cell proliferation (GO:0008285)	3.26	2	ANG, ERBB4
phospholipid metabolic process (GO:0006644)	3.88	2	FIG4, ERBB4
reproductive structure development (GO:0048608)	4.08	2	ANG, SOD1
multicellular organismal reproductive process (GO:0048609)	3.35	2	SOD1, SETX
cell proliferation (GO:0008283)	3.23	2	TBK1, ERBB4
cellular metal ion homeostasis (GO:0006875)	3.75	2	SOD1, VAPB
neurological system process (GO:0050877)	2.64	2	CHMP2B, SOD1
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	4.32	2	UBQLN2, VCP
cellular response to lipid (GO:0071396)	3.96	2	NEFH, SETX
cellular ion homeostasis (GO:0006873)	3.57	2	SOD1, VAPB
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	ANG, ATXN2
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	SETX, VCP
cellular cation homeostasis (GO:0030003)	3.6	2	SOD1, VAPB
axonogenesis (GO:0007409)	4.74	2	NEFH, ALS2
male gamete generation (GO:0048232)	3.7	2	SOD1, SETX
cation homeostasis (GO:0055080)	3.46	2	SOD1, VAPB
cellular chemical homeostasis (GO:0055082)	3.4	2	SOD1, VAPB
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	2	CHCHD10, VCP
regulation of mitochondrial membrane potential (GO:0051881)	5.72	2	SOD1, VCP
endosome organization (GO:0007032)	5.63	2	CHMP2B, ALS2
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	ANG, TARDBP
cellular response to growth factor stimulus (GO:0071363)	4.27	2	SETX, PFN1
negative regulation of viral process (GO:0048525)	5.07	2	TARDBP, VAPB
cellular response to organic cyclic compound (GO:0071407)	3.93	2	NEFH, SOD1
carbohydrate derivative metabolic process (GO:1901135)	3.07	2	CHCHD10, VCP
positive regulation of protein secretion (GO:0050714)	4.39	2	ANG, TARDBP
regulation of cytokine production (GO:0001817)	3.4	2	TBK1, SOD1
regulation of cellular catabolic process (GO:0031329)	3.83	2	UBQLN2, VCP
positive regulation of proteolysis (GO:0045862)	3.86	2	UBQLN2, VCP
positive regulation of cytokine production (GO:0001819)	3.82	2	TBK1, SOD1
cellular response to endogenous stimulus (GO:0071495)	3.33	2	SOD1, SETX
positive regulation of macroautophagy (GO:0016239)	6.07	2	TBK1, SQSTM1
glycerophospholipid metabolic process (GO:0006650)	4.13	2	FIG4, ERBB4
regulation of cellular localization (GO:0060341)	3.03	2	NEFH, ERBB4
regulation of small GTPase mediated signal transduction (GO:0051056)	4.08	2	ALS2, SQSTM1
regulation of viral release from host cell (GO:1902186)	6.29	2	CHMP2B, VAPB
macroautophagy (GO:0016236)	4.3	2	OPTN, SQSTM1
nucleic acid transport (GO:0050657)	4.59	2	HNRNPA1, ATXN2
purine-containing compound metabolic process (GO:0072521)	4.0	2	CHCHD10, VCP
gamete generation (GO:0007276)	3.61	2	SOD1, SETX
glycerolipid biosynthetic process (GO:0045017)	4.53	2	ANG, FIG4
ribonucleoprotein complex subunit organization (GO:0071826)	4.41	2	SETX, ATXN2
growth (GO:0040007)	3.8	2	SPG11, ERBB4
positive regulation of protein catabolic process (GO:0045732)	4.18	2	UBQLN2, VCP
response to lipid (GO:0033993)	3.11	2	NEFH, SETX
platelet degranulation (GO:0002576)	5.12	2	TUBA4A, SOD1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	ANG, HNRNPA1
cellular component morphogenesis (GO:0032989)	3.5	2	NEFH, ALS2
nitrogen compound transport (GO:0071705)	3.54	2	HNRNPA1, ATXN2
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052)	4.6	2	UBQLN2, VCP
positive regulation of autophagy (GO:0010508)	5.41	2	TBK1, SQSTM1
neurofilament cytoskeleton organization (GO:0060052)	7.53	2	NEFH, SOD1
positive regulation of cellular protein catabolic process (GO:1903364)	4.52	2	UBQLN2, VCP
regulation of cell migration (GO:0030334)	3.23	2	ERBB4, PFN1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	HNRNPA1, TARDBP
regulation of cellular protein catabolic process (GO:1903362)	4.23	2	UBQLN2, VCP
regulation of lipid metabolic process (GO:0019216)	4.08	2	SOD1, ERBB4
regulation of organ growth (GO:0046620)	5.41	2	SOD1, ERBB4
regulation of proteasomal protein catabolic process (GO:0061136)	4.78	2	UBQLN2, VCP
innate immune response (GO:0045087)	3.55	2	ANG, TBK1
apoptotic process (GO:0006915)	3.14	2	ERBB4, SQSTM1
RNA splicing, via transesterification reactions (GO:0000375)	4.25	2	FUS, HNRNPA1
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	4.27	2	FUS, HNRNPA1
cellular component disassembly (GO:0022411)	3.52	2	CHMP2B, SQSTM1
nucleoside metabolic process (GO:0009116)	4.12	2	CHCHD10, VCP
response to axon injury (GO:0048678)	5.86	2	NEFH, SOD1
regulation of receptor internalization (GO:0002090)	6.09	2	UBQLN2, ATXN2
cell-cell signaling (GO:0007267)	3.35	2	SPG11, ALS2
ribonucleoside metabolic process (GO:0009119)	4.21	2	CHCHD10, VCP
organelle assembly (GO:0070925)	3.75	2	CHMP2B, ATXN2
regulation of endocytosis (GO:0030100)	4.42	2	UBQLN2, ATXN2
locomotion (GO:0040011)	2.91	2	ANG, ERBB4
response to abiotic stimulus (GO:0009628)	2.8	2	ANG, SOD1
regulation of locomotion (GO:0040012)	3.12	2	ERBB4, PFN1
cell projection morphogenesis (GO:0048858)	4.05	2	NEFH, ALS2
regulation of cell cycle (GO:0051726)	2.93	2	CHMP2B, TARDBP
spermatogenesis (GO:0007283)	3.7	2	SOD1, SETX
ribose phosphate metabolic process (GO:0019693)	4.06	2	CHCHD10, VCP
glycosyl compound metabolic process (GO:1901657)	4.04	2	CHCHD10, VCP
regulation of translation (GO:0006417)	3.96	2	ANG, ATXN2
regulation of proteolysis (GO:0030162)	3.2	2	UBQLN2, VCP
negative regulation of endocytosis (GO:0045806)	6.04	2	UBQLN2, ATXN2
modification of morphology or physiology of other organism (GO:0035821)	5.12	2	TARDBP, VAPB
protein catabolic process (GO:0030163)	3.93	2	UBQLN2, VCP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.01	SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
positive regulation of protein modification process (GO:0031401)	-	2.7	0.002	VCP, SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.025	SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
intermediate filament cytoskeleton organization (GO:0045104)	-	6.04	0.02	NEFH, SOD1, PRPH
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.025	SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
negative regulation of multicellular organismal process (GO:0051241)	-	2.84	0.004	ATXN2, UBQLN2, HNRNPA1, VCP, SOD1, TBK1, DCTN1, ANG, FIG4, MATR3, SQSTM1
macroautophagy (GO:0016236)	-	4.3	0.045	OPTN, SQSTM1
positive regulation of protein metabolic process (GO:0051247)	-	2.43	0.013	VCP, SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
intermediate filament-based process (GO:0045103)	-	6.02	0.022	NEFH, SOD1, PRPH
interspecies interaction between organisms (GO:0044419)	-	3.08	0.014	ATXN2, UBQLN2, HNRNPA1, VCP, SOD1, FUS, TBK1, DCTN1, VAPB, CHMP2B, TARDBP, SQSTM1
microtubule cytoskeleton organization (GO:0000226)	NEW	4.13	0.043	PFN1, SOD1, DCTN1, TUBA4A, OPTN, NEFH, SQSTM1
regulation of cellular protein metabolic process (GO:0032268)	-	1.99	0.045	ATXN2, VCP, SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
positive regulation of cellular protein metabolic process (GO:0032270)	-	2.49	0.006	VCP, SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
regulation of protein modification process (GO:0031399)	-	2.32	0.045	VCP, SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
single-organism cellular process (GO:0044763)	-	0.65	0.0	HNRNPA1, TARDBP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, VCP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHCHD10, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
cell death (GO:0008219)	-	3.05	0.0	HNRNPA1, TARDBP, MATR3, VAPB, FIG4, SETX, SIGMAR1, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHMP2B, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, SQSTM1, C9orf72, ERBB4
positive regulation of protein phosphorylation (GO:0001934)	-	2.95	0.003	SOD1, TBK1, DCTN1, VAPB, ANG, ERBB4, ALS2, SQSTM1
single-organism process (GO:0044699)	-	0.48	0.005	HNRNPA1, TARDBP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, VCP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHCHD10, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	27	HNRNPA1, TARDBP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, VCP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHCHD10, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
cell part (GO:0044464)	0.11	27	HNRNPA1, TARDBP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, VCP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHCHD10, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
organelle (GO:0043226)	0.4	26	HNRNPA1, VCP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, PRPH, NEFH, SPG11, TARDBP, UBQLN2, ATXN2, FUS, CHMP2B, SQSTM1, C9orf72, ERBB4
intracellular organelle part (GO:0044446)	0.81	25	HNRNPA1, VCP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, TARDBP, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, PRPH, NEFH, SPG11, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
intracellular organelle (GO:0043229)	0.51	25	HNRNPA1, VCP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, NEFH, SPG11, TARDBP, UBQLN2, ATXN2, FUS, CHMP2B, SQSTM1, C9orf72, ERBB4
membrane-bounded organelle (GO:0043227)	0.47	25	HNRNPA1, VCP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, PFN1, ANG, OPTN, ALS2, SOD1, CHCHD10, PRPH, NEFH, SPG11, TARDBP, UBQLN2, ATXN2, FUS, CHMP2B, SQSTM1, C9orf72, ERBB4
organelle part (GO:0044422)	0.79	25	HNRNPA1, VCP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, TARDBP, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, PRPH, NEFH, SPG11, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
intracellular membrane-bounded organelle (GO:0043231)	0.6	23	HNRNPA1, VCP, MATR3, VAPB, FIG4, SETX, SIGMAR1, PFN1, ANG, OPTN, ALS2, SOD1, CHCHD10, NEFH, SPG11, TARDBP, UBQLN2, ATXN2, FUS, CHMP2B, SQSTM1, C9orf72, ERBB4
cytoplasmic part (GO:0044444)	0.82	22	VCP, VAPB, FIG4, TUBA4A, SIGMAR1, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
cytoplasm (GO:0005737)	1.01	19	SETX, ATXN2, UBQLN2, HNRNPA1, VCP, SOD1, FUS, TBK1, DCTN1, TUBA4A, PFN1, CHMP2B, ALS2, OPTN, C9orf72, NEFH, SPG11, TARDBP, SQSTM1
nucleus (GO:0005634)	1.07	18	SETX, ANG, UBQLN2, HNRNPA1, VCP, SOD1, FUS, MATR3, PFN1, CHMP2B, SIGMAR1, SQSTM1, OPTN, C9orf72, NEFH, SPG11, TARDBP, ERBB4
membrane (GO:0016020)	0.68	18	SIGMAR1, ATXN2, UBQLN2, HNRNPA1, VCP, SOD1, TBK1, PRPH, DCTN1, FIG4, VAPB, PFN1, CHMP2B, ALS2, OPTN, SPG11, MATR3, ERBB4
nuclear part (GO:0044428)	1.55	15	SIGMAR1, ATXN2, HNRNPA1, VCP, SOD1, FUS, MATR3, ANG, SETX, OPTN, C9orf72, SPG11, TARDBP, ERBB4, SQSTM1
vesicle (GO:0031982)	1.64	14	UBQLN2, HNRNPA1, VCP, SOD1, TUBA4A, PRPH, ANG, PFN1, CHMP2B, ALS2, OPTN, C9orf72, SPG11, SQSTM1
nucleoplasm (GO:0005654)	1.89	12	ATXN2, HNRNPA1, VCP, SOD1, FUS, MATR3, SETX, OPTN, C9orf72, TARDBP, ERBB4, SQSTM1
cytosol (GO:0005829)	1.68	12	VCP, SOD1, TBK1, DCTN1, TUBA4A, PFN1, CHMP2B, ALS2, OPTN, SPG11, ERBB4, SQSTM1
non-membrane-bounded organelle (GO:0043228)	1.76	12	SIGMAR1, ATXN2, VCP, PFN1, SETX, DCTN1, ANG, TUBA4A, SQSTM1, C9orf72, SPG11, ALS2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	12	SIGMAR1, ATXN2, VCP, PFN1, DCTN1, ANG, TUBA4A, SETX, C9orf72, SPG11, ALS2, SQSTM1
macromolecular complex (GO:0032991)	1.35	11	ATXN2, HNRNPA1, VCP, SOD1, FUS, ALS2, DCTN1, ANG, CHMP2B, SQSTM1, ERBB4
extracellular region part (GO:0044421)	1.57	11	HNRNPA1, VCP, SOD1, TUBA4A, PRPH, ANG, PFN1, CHMP2B, C9orf72, SPG11, SQSTM1
membrane-bounded vesicle (GO:0031988)	1.71	11	HNRNPA1, VCP, SOD1, TUBA4A, PRPH, ANG, PFN1, CHMP2B, OPTN, SPG11, SQSTM1
extracellular vesicle (GO:1903561)	1.89	10	HNRNPA1, VCP, SOD1, TUBA4A, PRPH, ANG, PFN1, CHMP2B, SPG11, SQSTM1
extracellular organelle (GO:0043230)	1.89	10	HNRNPA1, SOD1, VCP, TUBA4A, PRPH, ANG, PFN1, CHMP2B, SPG11, SQSTM1
extracellular exosome (GO:0070062)	1.89	10	HNRNPA1, SOD1, VCP, TUBA4A, PRPH, ANG, PFN1, CHMP2B, SPG11, SQSTM1
neuron part (GO:0097458)	2.64	9	SIGMAR1, PFN1, SOD1, FUS, ANG, SETX, NEFH, SPG11, ALS2
vacuole (GO:0005773)	2.92	8	UBQLN2, SOD1, FIG4, CHMP2B, SQSTM1, OPTN, C9orf72, ALS2
membrane part (GO:0044425)	0.95	8	SIGMAR1, VCP, DCTN1, CHMP2B, VAPB, FIG4, SPG11, ERBB4
cell projection (GO:0042995)	2.47	8	SIGMAR1, SOD1, PFN1, FUS, SETX, NEFH, SPG11, ALS2
organelle membrane (GO:0031090)	1.97	8	SIGMAR1, TBK1, CHMP2B, VAPB, FIG4, OPTN, SPG11, MATR3
protein complex (GO:0043234)	1.51	7	VCP, SOD1, DCTN1, ANG, CHMP2B, ERBB4, ALS2
cytoplasmic vesicle (GO:0031410)	2.87	7	UBQLN2, SOD1, ANG, OPTN, C9orf72, SPG11, SQSTM1
bounding membrane of organelle (GO:0098588)	2.39	7	SIGMAR1, TBK1, CHMP2B, VAPB, FIG4, OPTN, SPG11
cell projection part (GO:0044463)	2.97	7	SIGMAR1, SOD1, FUS, ANG, ALS2, SETX, SQSTM1
intracellular vesicle (GO:0097708)	2.86	7	UBQLN2, SOD1, ANG, OPTN, C9orf72, SPG11, SQSTM1
neuron projection (GO:0043005)	3.12	7	SOD1, PFN1, FUS, SETX, NEFH, SPG11, ALS2
endosome (GO:0005768)	3.25	6	FIG4, CHMP2B, SQSTM1, OPTN, C9orf72, ALS2
plasma membrane (GO:0005886)	1.39	6	SIGMAR1, UBQLN2, SOD1, CHMP2B, SPG11, ERBB4
endoplasmic reticulum (GO:0005783)	2.56	5	SIGMAR1, VAPB, FIG4, SQSTM1, VCP
integral component of membrane (GO:0016021)	1.14	5	SIGMAR1, FIG4, SPG11, ERBB4, VAPB
mitochondrion (GO:0005739)	2.42	5	SOD1, CHMP2B, NEFH, CHCHD10, ERBB4
cytoskeletal part (GO:0044430)	2.49	5	TUBA4A, PRPH, DCTN1, NEFH, ALS2
whole membrane (GO:0098805)	2.85	5	SIGMAR1, CHMP2B, SPG11, FIG4, TBK1
intrinsic component of membrane (GO:0031224)	1.13	5	SIGMAR1, FIG4, SPG11, ERBB4, VAPB
extracellular region (GO:0005576)	2.18	5	C9orf72, ANG, TUBA4A, SOD1, ERBB4
cytoskeleton (GO:0005856)	2.55	4	C9orf72, TUBA4A, DCTN1, PFN1
Golgi apparatus (GO:0005794)	2.7	4	VAPB, FIG4, ATXN2, OPTN
chromosomal part (GO:0044427)	3.18	4	TARDBP, DCTN1, SETX, VCP
supramolecular fiber (GO:0099512)	3.31	4	TUBA4A, DCTN1, NEFH, PRPH
polymeric cytoskeletal fiber (GO:0099513)	3.31	4	TUBA4A, DCTN1, NEFH, PRPH
lytic vacuole (GO:0000323)	3.89	4	C9orf72, CHMP2B, SOD1, SQSTM1
cell body (GO:0044297)	3.74	4	ANG, FUS, SOD1, ALS2
site of polarized growth (GO:0030427)	4.85	4	ANG, SIGMAR1, ALS2, SETX
growth cone (GO:0030426)	4.89	4	ANG, SIGMAR1, SETX, ALS2
autophagosome (GO:0005776)	5.64	4	C9orf72, UBQLN2, OPTN, SQSTM1
lysosome (GO:0005764)	3.89	4	C9orf72, CHMP2B, SOD1, SQSTM1
Golgi apparatus part (GO:0044431)	3.0	4	VAPB, FIG4, ATXN2, OPTN
vacuolar membrane (GO:0005774)	3.45	4	CHMP2B, SPG11, FIG4, TBK1
vacuolar part (GO:0044437)	3.26	4	CHMP2B, SPG11, FIG4, TBK1
axon (GO:0030424)	4.15	4	NEFH, SPG11, SETX, ALS2
ribonucleoprotein complex (GO:1990904)	3.19	4	FUS, HNRNPA1, ATXN2, SQSTM1
perinuclear region of cytoplasm (GO:0048471)	3.35	4	FUS, ATXN2, OPTN, VCP
intracellular ribonucleoprotein complex (GO:0030529)	3.19	4	FUS, HNRNPA1, ATXN2, SQSTM1
neuronal cell body (GO:0043025)	3.9	4	ANG, FUS, SOD1, ALS2
membrane protein complex (GO:0098796)	2.84	3	CHMP2B, DCTN1, VCP
synapse (GO:0045202)	3.58	3	SIGMAR1, SPG11, PFN1
organelle lumen (GO:0043233)	3.05	3	CHCHD10, SOD1, ERBB4
myelin sheath (GO:0043209)	4.76	3	NEFH, SOD1, VCP
extracellular space (GO:0005615)	2.63	3	ANG, C9orf72, SOD1
membrane-enclosed lumen (GO:0031974)	3.05	3	CHCHD10, SOD1, ERBB4
nucleolus (GO:0005730)	3.06	3	ANG, SPG11, SETX
intracellular organelle lumen (GO:0070013)	3.05	3	CHCHD10, SOD1, ERBB4
dendrite (GO:0030425)	3.92	3	FUS, SPG11, ALS2
Golgi membrane (GO:0000139)	3.28	3	FIG4, VAPB, OPTN
endoplasmic reticulum part (GO:0044432)	2.73	3	SIGMAR1, VAPB, VCP
synapse part (GO:0044456)	3.42	3	SIGMAR1, FUS, ALS2
mitochondrial part (GO:0044429)	2.92	3	CHCHD10, SOD1, ERBB4
endosomal part (GO:0044440)	3.73	3	CHMP2B, TBK1, FIG4
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	ANG, SOD1, OPTN
endoplasmic reticulum membrane (GO:0005789)	2.95	3	SIGMAR1, VAPB, VCP
endosome membrane (GO:0010008)	3.83	3	CHMP2B, TBK1, FIG4
plasma membrane region (GO:0098590)	2.97	2	SIGMAR1, ERBB4
lipid particle (GO:0005811)	5.66	2	SIGMAR1, VCP
ribonucleoprotein granule (GO:0035770)	4.81	2	ATXN2, SQSTM1
recycling endosome (GO:0055037)	5.11	2	FIG4, OPTN
inclusion body (GO:0016234)	5.55	2	NEFH, SQSTM1
cytoplasmic ribonucleoprotein granule (GO:0036464)	4.87	2	ATXN2, SQSTM1
microtubule (GO:0005874)	3.81	2	TUBA4A, DCTN1
cell junction (GO:0030054)	2.75	2	SIGMAR1, PFN1
organelle subcompartment (GO:0031984)	4.55	2	ATXN2, OPTN
perikaryon (GO:0043204)	5.13	2	FUS, NEFH
nuclear inner membrane (GO:0005637)	6.02	2	SIGMAR1, MATR3
late endosome (GO:0005770)	4.85	2	CHMP2B, SQSTM1
neuron spine (GO:0044309)	5.04	2	FUS, ALS2
microtubule organizing center (GO:0005815)	3.42	2	DCTN1, ALS2
postsynapse (GO:0098794)	4.87	2	FUS, ALS2
nucleoplasm part (GO:0044451)	3.22	2	TARDBP, SQSTM1
mitochondrial matrix (GO:0005759)	4.03	2	SOD1, ERBB4
mitochondrial intermembrane space (GO:0005758)	5.51	2	CHCHD10, SOD1
plasma membrane part (GO:0044459)	1.95	2	SIGMAR1, ERBB4
organelle envelope lumen (GO:0031970)	5.41	2	CHCHD10, SOD1
cytoplasmic region (GO:0099568)	4.51	2	SOD1, PFN1
nuclear membrane (GO:0031965)	4.2	2	SIGMAR1, MATR3
nuclear body (GO:0016604)	3.94	2	TARDBP, SQSTM1
postsynaptic density (GO:0014069)	4.77	2	SIGMAR1, ALS2
postsynaptic specialization (GO:0099572)	4.77	2	SIGMAR1, ALS2
polysome (GO:0005844)	6.16	2	FUS, ATXN2
dendritic spine (GO:0043197)	5.06	2	FUS, ALS2
trans-Golgi network (GO:0005802)	4.92	2	ATXN2, OPTN
organelle inner membrane (GO:0019866)	3.56	2	SIGMAR1, MATR3
late endosome membrane (GO:0031902)	5.16	2	CHMP2B, FIG4
intermediate filament (GO:0005882)	4.48	2	NEFH, PRPH
Golgi subcompartment (GO:0098791)	4.63	2	ATXN2, OPTN
centrosome (GO:0005813)	3.75	2	DCTN1, ALS2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
nucleoplasm (GO:0005654)	-	1.89	0.01	ATXN2, HNRNPA1, VCP, SOD1, FUS, TBK1, TUBA4A, CHMP2B, ERBB4, OPTN, TARDBP, SETX, SQSTM1
vesicle (GO:0031982)	-	1.64	0.004	HNRNPA1, VCP, MATR3, PRPH, SIGMAR1, TARDBP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, TUBA4A, VAPB, SPG11, UBQLN2, ATXN2, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
intracellular organelle (GO:0043229)	-	0.51	0.026	HNRNPA1, VCP, MATR3, VAPB, SETX, SIGMAR1, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, NEFH, SPG11, TARDBP, UBQLN2, ATXN2, FUS, CHMP2B, SQSTM1, C9orf72, ERBB4
cytoplasmic part (GO:0044444)	-	0.82	0.042	SIGMAR1, ATXN2, VCP, SOD1, SPG11, TBK1, ALS2, DCTN1, FIG4, VAPB, PFN1, TUBA4A, CHMP2B, SQSTM1, OPTN, PRPH, C9orf72, NEFH, CHCHD10, ERBB4
cytosol (GO:0005829)	-	1.68	0.016	VCP, SOD1, TBK1, ALS2, DCTN1, TUBA4A, PFN1, CHMP2B, SQSTM1, OPTN, SPG11, ERBB4
cell projection part (GO:0044463)	-	2.97	0.001	SIGMAR1, ATXN2, VCP, SOD1, TBK1, DCTN1, PRPH, ANG, PFN1, TUBA4A, ERBB4, OPTN, ALS2, SQSTM1
autophagic vacuole (GO:0005776)	-	5.64	0.0	C9orf72, TBK1, OPTN, SQSTM1
intracellular organelle part (GO:0044446)	-	0.81	0.0	HNRNPA1, VCP, MATR3, VAPB, FIG4, SETX, SIGMAR1, DCTN1, ANG, OPTN, ALS2, SOD1, CHMP2B, PRPH, NEFH, SPG11, ATXN2, FUS, TBK1, TUBA4A, SQSTM1, ERBB4
neuron part (GO:0097458)	-	2.64	0.042	SIGMAR1, ANG, VCP, SOD1, DCTN1, PRPH, PFN1, TUBA4A, ALS2, OPTN, NEFH, ERBB4, SQSTM1
neurofilament (GO:0005883)	NEW	7.61	0.008	NEFH, PRPH
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.038	SIGMAR1, ATXN2, HNRNPA1, PFN1, VCP, DCTN1, ANG, SETX, SPG11, ALS2, SQSTM1
nuclear part (GO:0044428)	-	1.55	0.007	SIGMAR1, ATXN2, HNRNPA1, VCP, SOD1, TARDBP, FUS, TBK1, DCTN1, TUBA4A, ANG, PFN1, CHMP2B, SETX, OPTN, ERBB4, SPG11, MATR3, SQSTM1
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.038	SIGMAR1, ATXN2, HNRNPA1, PFN1, VCP, DCTN1, ANG, SETX, SPG11, ALS2, SQSTM1
cytoplasmic vesicle (GO:0031410)	-	2.87	0.003	ATXN2, HNRNPA1, VCP, SOD1, TBK1, DCTN1, PFN1, SQSTM1, OPTN, C9orf72, SPG11, TARDBP, ERBB4
intracellular part (GO:0044424)	-	0.28	0.02	HNRNPA1, TARDBP, MATR3, VAPB, FIG4, TUBA4A, SETX, SIGMAR1, VCP, DCTN1, ANG, OPTN, ALS2, SOD1, PFN1, CHCHD10, PRPH, NEFH, SPG11, UBQLN2, ATXN2, FUS, TBK1, CHMP2B, SQSTM1, C9orf72, ERBB4
organelle (GO:0043226)	-	0.4	0.012	HNRNPA1, VCP, MATR3, VAPB, TUBA4A, SETX, SIGMAR1, PFN1, DCTN1, ANG, OPTN, ALS2, SOD1, CHCHD10, PRPH, NEFH, SPG11, TARDBP, UBQLN2, ATXN2, FUS, CHMP2B, SQSTM1, C9orf72, ERBB4
organelle part (GO:0044422)	-	0.79	0.001	HNRNPA1, VCP, MATR3, VAPB, FIG4, SETX, SIGMAR1, DCTN1, ANG, OPTN, ALS2, SOD1, CHMP2B, PRPH, NEFH, SPG11, ATXN2, FUS, TBK1, TUBA4A, SQSTM1, ERBB4
ciliary part (GO:0044441)	NEW	4.05	0.027	VCP, SOD1, DCTN1, PRPH, TUBA4A, OPTN, SQSTM1