Disease table of ATTENTION DEFICIT-HYPERACTIVITY DISORDER OMIM ID: 143465

Gene-disease associations table

GeneAssociated with ATTENTION DEFICIT-HYPERACTIVITY DISORDER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
DRD4OMIMHGNC link11p15.52143465, 601696
DRD5OMIMHGNC link4p16.12143465, 606798
MECP2ClinVarHGNC linkXq286300673, PS309510, PS209850, 312750, 143465, 105830

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
MECP2YES7CCND1, ALOX5, IGFBP3, TFF1, ESR1, GAD1, RELN0
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
DRD4DRD5No-3POMC, GNB1, GNG2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Dopaminergic synapsehsa047285.692DRD5, DRD4
Neuroactive ligand-receptor interactionhsa040804.582DRD5, DRD4

NET-GE enrichment

Term New enriched termICP valueGenes
Dopaminergic synapse (hsa04728) -5.690.004DRD5, DRD4
Circadian entrainment (hsa04713) NEW6.110.049DRD5, DRD4
Neuroactive ligand-receptor interaction (hsa04080) -4.580.017DRD5, DRD4
Substance dependenceNEW4.770.01DRD5, MECP2, DRD4
cAMP signaling pathway (hsa04024) NEW5.050.006DRD5, DRD4, MECP2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Amine ligand-binding receptorsR-HSA-3752807.592DRD5, DRD4
Signaling by GPCRR-HSA-3727902.682DRD5, DRD4
GPCR downstream signalingR-HSA-3883963.072DRD5, DRD4
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.692DRD5, DRD4
Dopamine receptorsR-HSA-39065110.662DRD5, DRD4
GPCR ligand bindingR-HSA-5007924.192DRD5, DRD4
Signal TransductionR-HSA-1625821.782DRD5, DRD4

NET-GE enrichment

Term New enriched termICP valueGenes
GABA receptor activation (R-HSA-977443) NEW7.20.007DRD5, DRD4
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076) -4.690.015DRD5, DRD4
GPCR ligand binding (R-HSA-500792) -4.190.03DRD5, DRD4
Amine ligand-binding receptors (R-HSA-375280) -7.590.0DRD5, DRD4
Dopamine receptors (R-HSA-390651) -10.660.0DRD5, DRD4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic cyclic compound binding (GO:0097159) 1.053DRD5, MECP2, DRD4
binding (GO:0005488) 0.183DRD5, MECP2, DRD4
dopamine neurotransmitter receptor activity, coupled via Gs (GO:0001588) 7.952DRD5, DRD4
G-protein coupled receptor activity (GO:0004930) 2.952DRD5, DRD4
neurotransmitter receptor activity (GO:0030594) 5.52DRD5, DRD4
signaling receptor activity (GO:0038023) 2.492DRD5, DRD4
protein binding (GO:0005515) 0.462MECP2, DRD4
catecholamine binding (GO:1901338) 6.972DRD5, DRD4
transmembrane signaling receptor activity (GO:0004888) 2.572DRD5, DRD4
molecular transducer activity (GO:0060089) 2.322DRD5, DRD4
dopamine neurotransmitter receptor activity (GO:0004952) 7.792DRD5, DRD4
dopamine binding (GO:0035240) 7.342DRD5, DRD4
receptor activity (GO:0004872) 2.322DRD5, DRD4
signal transducer activity (GO:0004871) 2.282DRD5, DRD4
transmembrane receptor activity (GO:0099600) 2.532DRD5, DRD4
protein domain specific binding (GO:0019904) 3.322MECP2, DRD4

NET-GE enrichment

Term New enriched termICP valueGenes
neurotransmitter receptor activity (GO:0030594) -5.50.022DRD5, DRD4
catecholamine binding (GO:1901338) -6.970.0DRD5, DRD4
ion channel activity (GO:0005216) NEW3.710.017DRD5, DRD4, MECP2
chloride transmembrane transporter activity (GO:0015108) NEW5.240.033MECP2, DRD4
dopamine neurotransmitter receptor activity (GO:0004952) -7.790.0DRD5, DRD4
channel activity (GO:0015267) NEW3.60.023DRD5, MECP2, DRD4
dopamine receptor binding (GO:0050780) NEW6.850.001DRD5, DRD4
anion channel activity (GO:0005253) NEW5.230.03MECP2, DRD4
inorganic anion transmembrane transporter activity (GO:0015103) NEW4.870.0DRD5, DRD4, MECP2
passive transmembrane transporter activity (GO:0022803) NEW3.60.023DRD5, DRD4, MECP2
dopamine binding (GO:0035240) -7.340.0DRD5, DRD4
substrate-specific channel activity (GO:0022838) NEW3.670.019DRD5, MECP2, DRD4
chloride channel activity (GO:0005254) NEW5.360.023MECP2, DRD4
anion transmembrane transporter activity (GO:0008509) NEW4.430.004DRD5, DRD4, MECP2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
negative regulation of metabolic process (GO:0009892) 1.933DRD5, DRD4, MECP2
positive regulation of metabolic process (GO:0009893) 1.743DRD5, DRD4, MECP2
regulation of metabolic process (GO:0019222) 1.023DRD5, DRD4, MECP2
regulation of cellular biosynthetic process (GO:0031326) 1.383DRD5, MECP2, DRD4
positive regulation of cellular metabolic process (GO:0031325) 1.813DRD5, DRD4, MECP2
learning (GO:0007612) 4.853DRD5, MECP2, DRD4
behavior (GO:0007610) 3.473DRD5, MECP2, DRD4
learning or memory (GO:0007611) 4.333DRD5, MECP2, DRD4
signaling (GO:0023052) 3.253DRD5, MECP2, DRD4
regulation of signaling (GO:0023051) 1.723DRD5, DRD4, MECP2
regulation of cell communication (GO:0010646) 1.733DRD5, DRD4, MECP2
regulation of biological process (GO:0050789) 0.453DRD5, DRD4, MECP2
single-organism process (GO:0044699) 0.483DRD5, MECP2, DRD4
regulation of primary metabolic process (GO:0080090) 1.083DRD5, DRD4, MECP2
biological regulation (GO:0065007) 0.393DRD5, MECP2, DRD4
response to organic cyclic compound (GO:0014070) 3.073DRD5, DRD4, MECP2
neurological system process (GO:0050877) 2.643DRD5, DRD4, MECP2
positive regulation of biological process (GO:0048518) 1.23DRD5, MECP2, DRD4
negative regulation of biological process (GO:0048519) 1.333DRD5, DRD4, MECP2
regulation of biological quality (GO:0065008) 1.683DRD5, DRD4, MECP2
multicellular organismal process (GO:0032501) 1.453DRD5, MECP2, DRD4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433DRD5, DRD4, MECP2
regulation of cellular metabolic process (GO:0031323) 1.073DRD5, MECP2, DRD4
cellular process (GO:0009987) 0.263DRD5, DRD4, MECP2
regulation of biosynthetic process (GO:0009889) 1.373DRD5, MECP2, DRD4
regulation of cellular process (GO:0050794) 0.53DRD5, MECP2, DRD4
response to stress (GO:0006950) 1.83DRD5, MECP2, DRD4
associative learning (GO:0008306) 5.443DRD5, DRD4, MECP2
single-organism cellular process (GO:0044763) 0.653DRD5, DRD4, MECP2
regulation of nitrogen compound metabolic process (GO:0051171) 1.363DRD5, DRD4, MECP2
metabolic process (GO:0008152) 0.583DRD5, DRD4, MECP2
chemical synaptic transmission (GO:0007268) 3.983DRD5, MECP2, DRD4
cell-cell signaling (GO:0007267) 3.353DRD5, MECP2, DRD4
response to chemical (GO:0042221) 1.983DRD5, DRD4, MECP2
modulation of synaptic transmission (GO:0050804) 4.093DRD5, DRD4, MECP2
response to organic substance (GO:0010033) 2.23DRD5, MECP2, DRD4
system process (GO:0003008) 2.33DRD5, DRD4, MECP2
single organism signaling (GO:0044700) 3.253DRD5, DRD4, MECP2
single-multicellular organism process (GO:0044707) 1.783DRD5, MECP2, DRD4
single-organism behavior (GO:0044708) 3.793DRD5, DRD4, MECP2
response to stimulus (GO:0050896) 1.223DRD5, DRD4, MECP2
cognition (GO:0050890) 4.23DRD5, DRD4, MECP2
cellular metabolic process (GO:0044237) 0.693DRD5, MECP2, DRD4
cell communication (GO:0007154) 3.043DRD5, MECP2, DRD4
anterograde trans-synaptic signaling (GO:0098916) 3.983DRD5, DRD4, MECP2
synaptic signaling (GO:0099536) 3.983DRD5, MECP2, DRD4
trans-synaptic signaling (GO:0099537) 3.983DRD5, DRD4, MECP2
negative regulation of cellular process (GO:0048523) 1.413DRD5, MECP2, DRD4
positive regulation of cellular process (GO:0048522) 1.33DRD5, DRD4, MECP2
regulation of phosphate metabolic process (GO:0019220) 2.352DRD5, DRD4
memory (GO:0007613) 5.132DRD4, MECP2
cation homeostasis (GO:0055080) 3.462DRD5, DRD4
calcium ion homeostasis (GO:0055074) 3.972DRD5, DRD4
inorganic ion homeostasis (GO:0098771) 3.432DRD5, DRD4
organic cyclic compound metabolic process (GO:1901360) 1.262DRD4, MECP2
positive regulation of macromolecule metabolic process (GO:0010604) 1.812DRD4, MECP2
dopamine receptor signaling pathway (GO:0007212) 6.262DRD5, DRD4
positive regulation of molecular function (GO:0044093) 2.232DRD5, DRD4
negative regulation of molecular function (GO:0044092) 2.742DRD5, DRD4
cellular homeostasis (GO:0019725) 3.232DRD5, DRD4
social behavior (GO:0035176) 5.92DRD4, MECP2
intraspecies interaction between organisms (GO:0051703) 5.92DRD4, MECP2
regulation of cyclase activity (GO:0031279) 5.322DRD5, DRD4
multi-organism behavior (GO:0051705) 5.62DRD4, MECP2
multi-organism process (GO:0051704) 2.652MECP2, DRD4
organonitrogen compound metabolic process (GO:1901564) 2.322DRD4, MECP2
regulation of macromolecule metabolic process (GO:0060255) 1.082DRD4, MECP2
response to organonitrogen compound (GO:0010243) 3.22DRD5, DRD4
regulation of purine nucleotide biosynthetic process (GO:1900371) 4.82DRD5, DRD4
multicellular organismal response to stress (GO:0033555) 5.672MECP2, DRD4
signal transduction (GO:0007165) 1.282DRD5, DRD4
regulation of membrane potential (GO:0042391) 3.892DRD4, MECP2
negative regulation of biosynthetic process (GO:0009890) 2.472DRD4, MECP2
positive regulation of biosynthetic process (GO:0009891) 2.292DRD5, MECP2
regulation of synaptic plasticity (GO:0048167) 4.782DRD5, MECP2
nitrogen compound metabolic process (GO:0006807) 1.132DRD4, MECP2
chemical homeostasis (GO:0048878) 2.972DRD5, DRD4
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 4.782DRD5, DRD4
behavioral defense response (GO:0002209) 6.432MECP2, DRD4
synaptic transmission, dopaminergic (GO:0001963) 7.022DRD5, DRD4
regulation of molecular function (GO:0065009) 1.782DRD5, DRD4
G-protein coupled receptor signaling pathway (GO:0007186) 2.642DRD5, DRD4
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 4.62DRD5, DRD4
locomotory behavior (GO:0007626) 4.532DRD4, MECP2
regulation of catalytic activity (GO:0050790) 1.972DRD5, DRD4
transport (GO:0006810) 1.512MECP2, DRD4
defense response (GO:0006952) 2.782DRD4, MECP2
regulation of multicellular organismal process (GO:0051239) 1.872MECP2, DRD4
regulation of postsynaptic membrane potential (GO:0060078) 5.722DRD4, MECP2
establishment of localization (GO:0051234) 1.482DRD4, MECP2
secretion (GO:0046903) 3.382DRD4, MECP2
response to nitrogen compound (GO:1901698) 3.122DRD5, DRD4
regulation of lyase activity (GO:0051339) 5.32DRD5, DRD4
response to amphetamine (GO:0001975) 6.362DRD5, DRD4
positive regulation of multicellular organismal process (GO:0051240) 2.492DRD4, MECP2
organic hydroxy compound metabolic process (GO:1901615) 3.842MECP2, DRD4
regulation of synapse structure or activity (GO:0050803) 4.772DRD5, MECP2
response to radiation (GO:0009314) 3.692MECP2, DRD4
ion homeostasis (GO:0050801) 3.422DRD5, DRD4
metal ion homeostasis (GO:0055065) 3.612DRD5, DRD4
positive regulation of synaptic transmission (GO:0050806) 5.072DRD4, MECP2
positive regulation of signaling (GO:0023056) 2.412DRD4, MECP2
response to light stimulus (GO:0009416) 4.082MECP2, DRD4
positive regulation of cell communication (GO:0010647) 2.412DRD4, MECP2
response to amine (GO:0014075) 5.882DRD5, DRD4
negative regulation of catalytic activity (GO:0043086) 3.02DRD5, DRD4
positive regulation of catalytic activity (GO:0043085) 2.42DRD5, DRD4
behavioral fear response (GO:0001662) 6.432DRD4, MECP2
response to endogenous stimulus (GO:0009719) 2.792DRD5, DRD4
divalent inorganic cation homeostasis (GO:0072507) 3.92DRD5, DRD4
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962DRD5, DRD4
regulation of cAMP biosynthetic process (GO:0030817) 5.012DRD5, DRD4
regulation of cAMP metabolic process (GO:0030814) 4.882DRD5, DRD4
regulation of protein metabolic process (GO:0051246) 1.932DRD4, MECP2
adult locomotory behavior (GO:0008344) 5.32MECP2, DRD4
regulation of protein modification process (GO:0031399) 2.322DRD4, MECP2
developmental process (GO:0032502) 1.362DRD4, MECP2
response to abiotic stimulus (GO:0009628) 2.82MECP2, DRD4
cellular metal ion homeostasis (GO:0006875) 3.752DRD5, DRD4
cellular calcium ion homeostasis (GO:0006874) 4.012DRD5, DRD4
cellular aromatic compound metabolic process (GO:0006725) 1.32DRD4, MECP2
cellular ion homeostasis (GO:0006873) 3.572DRD5, DRD4
cellular cation homeostasis (GO:0030003) 3.62DRD5, DRD4
regulation of cyclic nucleotide metabolic process (GO:0030799) 4.692DRD5, DRD4
cellular chemical homeostasis (GO:0055082) 3.42DRD5, DRD4
regulation of cellular protein metabolic process (GO:0032268) 1.992DRD4, MECP2
regulation of nucleotide biosynthetic process (GO:0030808) 4.792DRD5, DRD4
regulation of cyclic nucleotide biosynthetic process (GO:0030802) 4.852DRD5, DRD4
positive regulation of cellular biosynthetic process (GO:0031328) 2.32DRD5, MECP2
negative regulation of cellular biosynthetic process (GO:0031327) 2.492MECP2, DRD4
negative regulation of cellular metabolic process (GO:0031324) 2.012MECP2, DRD4
homeostatic process (GO:0042592) 2.612DRD5, DRD4
fear response (GO:0042596) 6.362DRD4, MECP2
neuron-neuron synaptic transmission (GO:0007270) 5.742DRD5, DRD4
regulation of adenylate cyclase activity (GO:0045761) 5.512DRD5, DRD4
organic substance metabolic process (GO:0071704) 0.632MECP2, DRD4
organic substance transport (GO:0071702) 2.152MECP2, DRD4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352DRD5, MECP2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552DRD4, MECP2
positive regulation of phosphate metabolic process (GO:0045937) 2.782DRD5, DRD4
positive regulation of phosphorus metabolic process (GO:0010562) 2.782DRD5, DRD4
regulation of phosphorus metabolic process (GO:0051174) 2.352DRD5, DRD4
single-organism transport (GO:0044765) 2.182DRD4, MECP2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472MECP2, DRD4
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292DRD5, MECP2
localization (GO:0051179) 1.42DRD4, MECP2
single-organism localization (GO:1902578) 2.092DRD4, MECP2
response to oxygen-containing compound (GO:1901700) 2.572DRD5, MECP2
adult behavior (GO:0030534) 4.792DRD4, MECP2
regulation of purine nucleotide metabolic process (GO:1900542) 4.412DRD5, DRD4
anatomical structure development (GO:0048856) 1.582MECP2, DRD4
response to lipid (GO:0033993) 3.112MECP2, DRD4
regulation of nucleotide metabolic process (GO:0006140) 4.382DRD5, DRD4

NET-GE enrichment

Term New enriched termICP valueGenes
learning (GO:0007612) -4.850.006DRD5, MECP2, DRD4
memory (GO:0007613) -5.130.039MECP2, DRD4
behavior (GO:0007610) -3.470.011DRD5, MECP2, DRD4
learning or memory (GO:0007611) -4.330.04DRD5, MECP2, DRD4
regulation of excitatory postsynaptic membrane potential (GO:0060079) NEW6.430.013MECP2, DRD4
regulation of gamma-aminobutyric acid secretion (GO:0014052) NEW7.940.001DRD5, DRD4
fear response (GO:0042596) -6.360.0DRD5, DRD4, MECP2
neuron-neuron synaptic transmission (GO:0007270) -5.740.017DRD5, DRD4
response to amine (GO:0014075) -5.880.007DRD5, DRD4
regulation of cAMP biosynthetic process (GO:0030817) -5.010.046DRD5, DRD4
behavioral fear response (GO:0001662) -6.430.0DRD5, MECP2, DRD4
dopamine receptor signaling pathway (GO:0007212) -6.260.003DRD5, DRD4
regulation of adenylate cyclase activity (GO:0045761) -5.510.018DRD5, DRD4
behavioral defense response (GO:0002209) -6.430.0DRD5, DRD4, MECP2
synaptic transmission, dopaminergic (GO:0001963) -7.020.001DRD5, DRD4
inorganic anion transmembrane transport (GO:0098661) NEW5.040.002DRD5, MECP2, DRD4
neurological system process (GO:0050877) -2.640.036DRD5, MECP2, DRD4
inorganic anion transport (GO:0015698) NEW4.770.004DRD5, DRD4, MECP2
positive regulation of amine transport (GO:0051954) NEW6.510.019DRD5, DRD4
regulation of amino acid transport (GO:0051955) NEW7.090.019DRD5, DRD4
social behavior (GO:0035176) -5.90.008MECP2, DRD4
response to ammonium ion (GO:0060359) NEW8.120.02DRD5, DRD4
positive regulation of ion transport (GO:0043270) NEW4.360.015DRD5, MECP2, DRD4
associative learning (GO:0008306) -5.440.001DRD5, MECP2, DRD4
response to histamine (GO:0034776) NEW7.330.002DRD5, DRD4
response to cocaine (GO:0042220) NEW5.990.005DRD5, DRD4
regulation of postsynaptic membrane potential (GO:0060078) -5.720.017DRD5, DRD4, MECP2
regulation of synaptic transmission (GO:0050804) -4.090.001DRD5, MECP2, DRD4
regulation of cyclase activity (GO:0031279) -5.320.025DRD5, DRD4
adult locomotory behavior (GO:0008344) -5.30.036DRD4, MECP2
multi-organism behavior (GO:0051705) -5.60.0DRD5, DRD4, MECP2
adult behavior (GO:0030534) -4.790.02DRD5, MECP2, DRD4
intraspecies interaction between organisms (GO:0051703) -5.90.008MECP2, DRD4
single-organism behavior (GO:0044708) -3.790.004DRD5, MECP2, DRD4
cognition (GO:0050890) -4.20.001DRD5, DRD4, MECP2
regulation of lyase activity (GO:0051339) -5.30.028DRD5, DRD4
response to amphetamine (GO:0001975) -6.360.031DRD5, DRD4
multicellular organismal response to stress (GO:0033555) -5.670.001DRD5, DRD4, MECP2
anion transmembrane transport (GO:0098656) NEW4.510.009DRD5, MECP2, DRD4
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.113DRD5, MECP2, DRD4
organelle part (GO:0044422) 0.793DRD5, MECP2, DRD4
cytoplasm (GO:0005737) 1.012DRD4, MECP2
cell projection part (GO:0044463) 2.972DRD5, DRD4
organelle membrane (GO:0031090) 1.972DRD5, DRD4
plasma membrane part (GO:0044459) 1.952DRD5, DRD4
integral component of membrane (GO:0016021) 1.142DRD5, DRD4
membrane (GO:0016020) 0.682DRD5, DRD4
cytoplasmic part (GO:0044444) 0.822DRD4, MECP2
synapse part (GO:0044456) 3.422DRD4, MECP2
integral component of plasma membrane (GO:0005887) 2.572DRD5, DRD4
plasma membrane (GO:0005886) 1.392DRD5, DRD4
intracellular part (GO:0044424) 0.282MECP2, DRD4
membrane part (GO:0044425) 0.952DRD5, DRD4
cell projection (GO:0042995) 2.472DRD5, DRD4
intrinsic component of plasma membrane (GO:0031226) 2.532DRD5, DRD4
organelle (GO:0043226) 0.42DRD5, MECP2
intrinsic component of membrane (GO:0031224) 1.132DRD5, DRD4
postsynapse (GO:0098794) 4.872DRD4, MECP2