Disease table of MENTAL RETARDATION, X-LINKED SYNDROMIC OMIM ID: PS309510

Gene-disease associations table

GeneAssociated with MENTAL RETARDATION, X-LINKED SYNDROMIC inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HSD17B10ClinVar, OMIMHGNC linkXp11.222300438, PS309510
UPF3BClinVar, OMIM, HUMSAVARHGNC linkXq241PS309510
HDAC8ClinVar, OMIMHGNC linkXq13.12PS309510, PS122470
HUWE1ClinVar, OMIM, HUMSAVARHGNC linkXp11.221PS309510
SMSClinVar, OMIM, HUMSAVARHGNC linkXp22.111PS309510
AP1S2ClinVar, OMIMHGNC linkXp22.21PS309510
CLIC2ClinVar, OMIM, HUMSAVARHGNC linkXq281PS309510
SLC9A6ClinVar, OMIMHGNC linkXq26.31PS309510
PRPS1ClinVar, OMIM, HUMSAVARHGNC linkXq22.34PS118220, PS304500, 300661, PS309510
NONOClinVar, OMIMHGNC linkXq13.11PS309510
CASKClinVar, OMIM, HUMSAVARHGNC linkXp11.42300422, PS309510
ATP6AP2ClinVar, OMIMHGNC linkXp11.42PS309510, 300911
GRIA3ClinVar, OMIM, HUMSAVARHGNC linkXq252PS309510, PS309530
IGBP1OMIMHGNC linkXq13.11PS309510
RAB40ALClinVar, HUMSAVARHGNC linkXq22.11PS309510
FGD1ClinVar, OMIM, HUMSAVARHGNC linkXp11.221PS309510
MECP2ClinVar, OMIM, HUMSAVARHGNC linkXq286300673, PS309510, PS209850, 312750, 143465, 105830
TAF1ClinVar, OMIMHGNC linkXq13.12PS309510, PS128100
ARXClinVar, OMIMHGNC linkXp21.35PS607432, PS309510, 300004, PS308350, PS309530
PQBP1ClinVar, OMIM, HUMSAVARHGNC linkXp11.231PS309510
RBMXOMIMHGNC linkXq26.31PS309510
UBE2AClinVar, OMIM, HUMSAVARHGNC linkXq241PS309510
CUL4BClinVar, OMIM, HUMSAVARHGNC linkXq241PS309510
PHF8ClinVar, OMIM, HUMSAVARHGNC linkXp11.221PS309510
PHF6ClinVar, OMIM, HUMSAVARHGNC linkXq26.21PS309510
ZDHHC9ClinVar, OMIM, HUMSAVARHGNC linkXq26.11PS309510
KDM5CClinVar, OMIM, HUMSAVARHGNC linkXp11.221PS309510

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
Xp11.225HSD17B10, FGD1, HUWE1, KDM5C, PHF8
Xp11.42CASK, ATP6AP2
Xq282CLIC2, MECP2
Xq243UBE2A, CUL4B, UPF3B
Xq13.14NONO, IGBP1, TAF1, HDAC8
Xq26.32RBMX, SLC9A6
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
Xq282CLIC2, MECP2
Xq264RBMX, PHF6, ZDHHC9, SLC9A6
Xp222SMS, AP1S2
Xq134NONO, IGBP1, TAF1, HDAC8
Xq243UBE2A, CUL4B, UPF3B
Xq222PRPS1, RAB40AL
Xp118PHF8, KDM5C, PQBP1, FGD1, CASK, HUWE1, HSD17B10, ATP6AP2
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
Xq14NONO, IGBP1, TAF1, HDAC8
Xp18PHF8, KDM5C, PQBP1, FGD1, CASK, HUWE1, HSD17B10, ATP6AP2
Xq212PHF6, ZDHHC9, PRPS1, UPF3B, CLIC2, SLC9A6, CUL4B, RAB40AL, UBE2A, MECP2, GRIA3, RBMX
Xp23SMS, AP1S2, ARX
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
Xp11SMS, PHF8, KDM5C, AP1S2, PQBP1, FGD1, CASK, HUWE1, HSD17B10, ARX, ATP6AP2
Xq16PHF6, TAF1, PRPS1, UPF3B, CLIC2, SLC9A6, CUL4B, RAB40AL, NONO, IGBP1, MECP2, GRIA3, RBMX, UBE2A, ZDHHC9, HDAC8
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
X27PHF8, CUL4B, UPF3B, AP1S2, KDM5C, UBE2A, HSD17B10, HUWE1, RAB40AL, GRIA3, ARX, SMS, CLIC2, PQBP1, NONO, IGBP1, RBMX, PHF6, PRPS1, TAF1, MECP2, CASK, ATP6AP2, ZDHHC9, SLC9A6, FGD1, HDAC8
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
MECP2YES7CCND1, ALOX5, IGFBP3, TFF1, ESR1, GAD1, RELN0
TAF1YES4SRC, LRIG2, CDKN1A, TBP0
ARXYES1KDM5C1KDM5C
RBMXYES8KIT, EGR1, FOSL1, ROS1, JUNB, FOS, JUND, TXNIP0
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HDAC8YES1SOX40
KDM5CYES1ARX1ARX
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HSD17B10UPF3BNo3CUL5, COPS5, CAND1
HSD17B10HUWE1Yes16DLD, PHB, RUVBL1, UBE2D1, MCM2, HUWE1, WWOX, UBA1, HNRNPA2B1, ALDOA, ENO1, EGFR, NTRK1, EEF2, CUL3, RTN4
HSD17B10SMSNo2NTRK1, UCHL3
HSD17B10AP1S2No1EGFR
HSD17B10CLIC2No1FN1
HSD17B10PRPS1No2NTRK1, PARK2
HSD17B10NONONo16DLD, FN1, WWOX, PTBP1, CUL3, HUWE1, OBSL1, CAND1, HNRNPA3, RPL35, CUL7, NTRK1, COPS5, HDAC5, H2AFX, ITGA4
HSD17B10CASKNo3NTRK1, EEF2, PARK2
HSD17B10ATP6AP2No2FKBP2, ENO1
HSD17B10IGBP1No5UBE2D1, TAGLN2, APP, TKT, STIP1
HSD17B10RAB40ALNo1CUL5
HSD17B10MECP2No1SOX2
HSD17B10PQBP1No3EEF1A1, OBSL1, APP
HSD17B10RBMXNo13FN1, WWOX, CUL7, TARDBP, MCM2, CUL3, OBSL1, CAND1, ITGA4, NTRK1, EEF1A1, HDAC5, HDGF
HSD17B10UBE2ANo3UCHL3, UBA1, PSMB1
HSD17B10CUL4BYes16HNRNPA2B1, HSPA9, ENO2, MCM2, CUL3, HNRNPAB, CAND1, HNRNPA3, ALDOA, COPS5, CUL5, EGFR, NTRK1, EEF2, APP, ENO1
HSD17B10PHF8No1APP
HSD17B10PHF6No7HNRNPA2B1, CHD3, CAND1, HNRNPA3, CUL3, NTRK1, HDGF
UPF3BHDAC8No1SMG6
UPF3BHUWE1No4NCBP1, EIF4A3, SNRPA1, XPO1
UPF3BAP1S2No1XPO1
UPF3BNONONo4STAU1, COPS5, CAND1, XPO1
UPF3BCASKNo1SRPK2
UPF3BATP6AP2No1NXF1
UPF3BIGBP1No1HIST1H2BG
UPF3BRAB40ALNo1CUL5
UPF3BMECP2No2HECW2, HIST1H2BG
UPF3BTAF1No1NXF1
UPF3BPQBP1No1WBP11
UPF3BRBMXNo8STAU1, EIF4A3, RBM8A, MEPCE, CAND1, SRPK2, MAGOH, NXF1
UPF3BCUL4BNo4CUL5, COPS5, NXF1, CAND1
UPF3BPHF8No2UPF3A, EIF6
UPF3BPHF6No5SRPK2, MAGOH, HECW2, HIST1H2BG, CAND1
UPF3BKDM5CNo2NXF1, XPO1
HDAC8HUWE1No4HSPA4, UBXN1, DDB1, HSP90AA1
HDAC8NONONo2PPP1CC, HIST3H3
HDAC8IGBP1No1UBXN1
HDAC8MECP2No3HIST1H3A, CREB1, SMC3
HDAC8TAF1No3HIST1H3A, HIST3H3, HIST1H4A
HDAC8ARXNo1SEC16A
HDAC8RBMXNo1PPP1CC
HDAC8UBE2ANo1UBXN1
HDAC8CUL4BNo3VPRBP, DDB1, HSP90AA1
HDAC8PHF8No3HIST1H3A, HIST3H3, HIST1H4A
HUWE1SMSNo4HSPD1, NTRK1, LDHA, CSE1L
HUWE1AP1S2No3EGFR, XPO1, TENC1
HUWE1PRPS1No5NTRK1, UBB, YWHAE, FBXO6, PRPF19
HUWE1NONOYes22WWOX, CDC5L, HDAC2, XPO1, PPP1CA, SFPQ, CRY2, REV, NONO, RPA2, DLD, CTNNB1, HUWE1, NDUFS3, CA2, U2AF2, CCDC8, HNRNPU, NTRK1, MYC, PSMA3, CUL3
HUWE1CASKNo6SMEK1, MARS, PCBP2, NTRK1, EEF2, DLG1
HUWE1ATP6AP2No5UNK, RANGAP1, CD2AP, TFRC, ENO1
HUWE1IGBP1No23DDOST, TIPRL, STAT1, UNK, CCT5, CCT3, SRSF1, TCP1, CCT8, HSPB1, NUDC, CCT4, CCT7, UBXN1, PPIA, CCT2, CCT6A, METTL21B, SMEK1, UBE2D1, PDIA6, PCBP1, USP9X
HUWE1RAB40ALNo1PSME3
HUWE1MECP2No3TEAD2, HMGB1, HIST2H2BE
HUWE1TAF1No5TBP, ATM, MYC, GTF2A1, TP53
HUWE1ARXNo1CLTC
HUWE1PQBP1No1UBL4A
HUWE1RBMXNo18CCDC8, EIF4A3, WWOX, FBXO6, CDC5L, RB1CC1, SF3A1, MCM2, HNRNPK, SIRT7, AHSA1, HNRNPH1, NUCKS1, SF3B3, CTNNB1, NTRK1, CUL3, FBXW11
HUWE1UBE2ANo12UNK, UBA1, UBXN1, RPA2, PRPF19, HIST2H2BE, TP53, UBE2L3, PCNA, UBC, CDKN2A, CSE1L
HUWE1CUL4BNo77HNRNPK, ALDOA, SSB, HSP90AB1, RPS7, RPS18, HIST1H2AE, SIRT7, RPS3, RPL7P32, USP15, RPS4X, RBBP7, AHCY, RPL8, EGFR, EEF2, PGAM5, HSPA5, SHFM1, DDB1, HIST2H2BE, TP53, HSD17B10, C1QBP, MCM2, PSMA1, SNRPB, NAP1L1, RPL6, HNRNPA2B1, RPS16, SRSF1, ENO1, PPIA, RPL3, TUBA1C, RPL13, RPS8, LDHB, CALM1, SNRPD3, GAPDH, RPLP0, DDX1, RPS25, TUBB4B, RPL4, USP4, RPL15, UBC, RPL27A, ILF2, KHSRP, HSP90AA1, PCNA, TUFM, SLC25A5, USP7, MCCC1, WDR82, RPS14, RPS24, DNAJA1, HDAC2, RPL27, SRSF3, KPNA2, TUBB, HNRNPH1, RPL12, RPL18, NCL, NTRK1, C14ORF166, KPNB1, CUL3
HUWE1PHF8No5MAML1, HNRNPU, CDC20, HIST2H2BE, LSM14B
HUWE1PHF6No17PRPF8, RPL22, RBBP4, RPS25, RPS18, PCBP2, RBBP7, HNRNPA2B1, HNRNPU, RPLP0, RPL4, SNRNP200, NPM1, NTRK1, TUBA1C, SRP14, CUL3
HUWE1KDM5CNo6TOX4, CALM1, HDAC2, XPO1, SET, PCNA
SMSAP1S2No1ELAVL1
SMSSLC9A6No1ELAVL1
SMSPRPS1No2NTRK1, TP53RK
SMSNONONo2NTRK1, ELAVL1
SMSCASKNo2NTRK1, ELAVL1
SMSATP6AP2No3PPP1R13L, PDIA3, ATP6V1C1
SMSIGBP1Yes1NUDCD2
SMSFGD1No1ELAVL1
SMSMECP2No1ELAVL1
SMSRBMXNo1NTRK1
SMSUBE2ANo4HDLBP, XIAP, CSE1L, UCHL3
SMSCUL4BNo2NTRK1, ELAVL1
SMSPHF6No1NTRK1
AP1S2SLC9A6No1ELAVL1
AP1S2NONONo2ELAVL1, XPO1
AP1S2CASKNo1ELAVL1
AP1S2ATP6AP2No2CLINT1, CLTA
AP1S2FGD1No2GGCX, ELAVL1
AP1S2MECP2No1ELAVL1
AP1S2ARXNo2CLINT1, CLTA
AP1S2CUL4BNo3UBE2M, ELAVL1, EGFR
AP1S2KDM5CNo1XPO1
CLIC2NONONo1FN1
CLIC2RBMXNo1FN1
SLC9A6NONONo1ELAVL1
SLC9A6CASKNo1ELAVL1
SLC9A6IGBP1No1LGALS3
SLC9A6FGD1No1ELAVL1
SLC9A6MECP2No1ELAVL1
SLC9A6CUL4BNo1ELAVL1
PRPS1NONONo3GORASP2, NTRK1, ASB18
PRPS1CASKNo2NTRK1, PARK2
PRPS1IGBP1No1PFDN1
PRPS1TAF1No2GTF2F1, BRMS1
PRPS1RBMXNo2NTRK1, FBXO6
PRPS1UBE2ANo2TWF1, PRPF19
PRPS1CUL4BNo2NTRK1, TUBA4A
PRPS1PHF6No1NTRK1
NONOCASKNo3NTRK1, LIN7C, ELAVL1
NONOATP6AP2No3RALA, ATP6V0A1, UBAC2
NONOIGBP1No3EWSR1, SIN3A, SFN
NONOFGD1No1ELAVL1
NONOMECP2No8SMARCA2, SPI1, HDAC1, SIN3A, SCARNA22, PRPF40A, ELAVL1, SMARCB1
NONOTAF1No6SMARCA2, HIST3H3, SIN3A, AR, MYC, UBE2I
NONOPQBP1No6OBSL1, ZC3H11A, ESR1, EWSR1, SCO2, APBB1
NONORBMXNo33RRM2, HNRNPA1, CDC5L, FN1, IL7R, SRRM1, CAND1, SNW1, SNRPA, FXR2, SRRM2, VCAM1, SCARNA22, KSR1, SOCS3, PAN2, CTNNB1, HDAC5, ITGA4, OBSL1, WWOX, EED, PPP1CB, PPP1CC, AI837181, STAU1, FUS, CCDC8, HNRNPM, CUL3, ESR1, NTRK1, CUL7
NONOUBE2ANo3RPA3, RPA2, PIN1
NONOCUL4BNo17HSPA1A, HNRNPA1, FUS, APBB1, HDAC1, HDAC2, CAND1, HNRNPA3, EWSR1, COPS5, ELAVL1, NTRK1, SIN3A, SNRPA, CUL2, CUL3, KSR1
NONOPHF8No2HNRNPU, HIST3H3
NONOPHF6No6HDAC1, CAND1, HNRNPA3, HNRNPU, NTRK1, CUL3
NONOKDM5CNo3HDAC1, HDAC2, XPO1
CASKATP6AP2No1TMEM17
CASKGRIA3No1DLG4
CASKIGBP1No1SMEK1
CASKFGD1No1ELAVL1
CASKMECP2No1ELAVL1
CASKRBMXNo2NTRK1, SRPK2
CASKUBE2ANo1CDK9
CASKCUL4BNo3NTRK1, EEF2, ELAVL1
CASKPHF8No1TRIM26
CASKPHF6No3NTRK1, PCBP2, SRPK2
CASKKDM5CNo1TSPYL2
ATP6AP2GRIA3No1PICK1
ATP6AP2IGBP1No5UNK, ATP6V1F, LGALS1, TES, NUMB
ATP6AP2FGD1No1ESYT2
ATP6AP2TAF1No1NXF1
ATP6AP2ARXNo2CLINT1, CLTA
ATP6AP2RBMXNo1NXF1
ATP6AP2UBE2ANo2UNK, CD59
ATP6AP2CUL4BNo4NXF1, JUP, ENO1, STUB1
ATP6AP2KDM5CNo1NXF1
GRIA3UBE2ANo1SDCBP
IGBP1MECP2No2SIN3A, HIST1H2BG
IGBP1TAF1No1SIN3A
IGBP1PQBP1No2EWSR1, APP
IGBP1RBMXNo1RAC1
IGBP1UBE2ANo9UNK, UBQLN2, UBXN1, TYMS, UBR5, POMP, PRDX5, ZFYVE19, UBE2B
IGBP1CUL4BNo10PPIA, TLE3, PABPC1, SIN3A, SRSF1, PABPC4, EWSR1, NEDD8, APP, RPLP1
IGBP1PHF8No3RPAP1, SUMO2, APP
IGBP1PHF6No1HIST1H2BG
RAB40ALCUL4BNo1CUL5
FGD1MECP2No2CDC42, ELAVL1
FGD1CUL4BNo1ELAVL1
MECP2TAF1No5MAX, CHMP4B, SMARCA2, SIN3A, HIST1H3A
MECP2RBMXNo1SCARNA22
MECP2UBE2ANo2CBX5, HIST2H2BE
MECP2CUL4BNo5HDAC1, SIN3A, ELAVL1, YBX1, HIST2H2BE
MECP2PHF8No5XPC, H2AFY, HIST1H3A, RBPJ, HIST2H2BE
MECP2PHF6No3HDAC1, HIST1H2BG, HECW2
MECP2KDM5CNo5MAX, HDAC1, NCOR1, HIST2H3A, CBX3
TAF1RBMXNo2NXF1, CSNK2A1
TAF1UBE2ANo3CCNT1, TP53, MDM2
TAF1CUL4BNo4NXF1, SIN3A, TP53, MDM2
TAF1PHF8Yes3HIST1H3A, HIST3H3, HIST1H4A
TAF1KDM5CNo3MAX, NXF1, CSNK2A1
ARXCUL4BNo1RBM4
PQBP1RBMXNo7OBSL1, RPS28, HNRNPH2, SF3A2, ESR1, EEF1A1, LNX1
PQBP1CUL4BNo5EWSR1, HNRNPH2, APBB1, COPS7A, APP
PQBP1PHF8No2POLR2A, APP
RBMXCUL4BNo23HNRNPR, HNRNPA1, FAM103A1, RPL31, HNRNPK, HNRNPUL1, HNRNPH2, KSR1, NXF1, SNRPA, DDX5, MCM2, SIRT7, RBM3, HNRNPF, DHX15, FUS, RBM14, CAND1, HNRNPH1, HNRNPD, NTRK1, CUL3
RBMXPHF6No8HNRNPC, MAGOH, RALY, CAND1, HDGF, NTRK1, SRPK2, CUL3
RBMXKDM5CNo3NXF1, CSNK2A1, RNF2
UBE2ACUL4BNo9HIST2H2BE, MDM2, CDK2, TP53, TRIM27, XRN2, PCNA, UBC, BPLF1
UBE2APHF8No1HIST2H2BE
UBE2AKDM5CNo1PCNA
CUL4BPHF8No3WDR5, HIST2H2BE, APP
CUL4BPHF6No16HNRNPA2B1, RPLP0, HNRNPH3, RPS18, HDAC1, UBXN7, RPS25, TUBA1C, HNRNPA3, RBBP7, CAND1, HIST1H1C, NTRK1, RPL4, RPL30, CUL3
CUL4BKDM5CNo5CALM1, HDAC1, HDAC2, NXF1, PCNA
PHF8PHF6No1HNRNPU
PHF6KDM5CNo1HDAC1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HUWE1NONONo1KRAS
HUWE1TAF1No1KRAS
NONOTAF1No1KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
UPF3BNONONo-2FUS, U2AF2
UPF3BIGBP1No-2SMG1, PPP2CA
UPF3BTAF1No-14POLR2I, POLR2G, POLR2K, POLR2J, POLR2A, POLR2D, POLR2L, GTF2F1, POLR2H, POLR2F, POLR2C, POLR2E, GTF2F2, POLR2B
UPF3BRBMXYesbinding97EIF4A3, CDC40, HNRNPR, SNRPD2, SNRPD1, SNRNP200, RNPS1, SNRPE, POLR2B, DHX9, PAPOLA, SNRPB, POLR2L, PRPF6, DHX38, SRSF11, SF3A1, POLR2I, CLP1, POLR2A, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, PRPF8, U2AF2, SF3B2, HNRNPL, HNRNPUL1, SF3B1, MAGOH, PTBP1, NCBP2, PCBP2, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, DDX23, HNRNPA3, SF3A2, NUDT21, POLR2D, NCBP1, HNRNPM, EFTUD2, HNRNPK, U2AF1, CSTF3, POLR2J, HNRNPA1, POLR2F, SRSF6, HNRNPA2B1, POLR2C, GTF2F1, SRSF5, SRSF7, TXNL4A, CD2BP2, SUGP1, SNRPB2, FUS, HNRNPA0, PRPF4, HNRNPU, CSTF1, SNRPF, SRSF2, NFX1, SRRM1, CSTF2, YBX1, DNAJC8, POLR2H, SNRPD3, SF3B5, SNRPA1, SRSF1, SNRNP40, SRSF9, PCBP1, RBM5, ALYREF, SF3B3, CCAR1, HNRNPC, PABPN1, HNRNPF, SRSF3, HNRNPH1, CPSF7, POLR2E, NHP2L1
UPF3BUBE2ANo-2UBA52, RPS27A
UPF3BZDHHC9No-1ETF1
HUWE1SMSNo-1UBC
HUWE1NONONo-1UBC
HUWE1ATP6AP2No-1UBC
HUWE1IGBP1No-1UBC
HUWE1TAF1No-3MAX, UBC, TP53
HUWE1RBMXNo-1UBC
HUWE1UBE2ANo-2UBC, TP53
HUWE1CUL4BNo-1UBC
HUWE1PHF6No-1UBC
HUWE1ZDHHC9No-1UBC
SMSNONONo-1UBC
SMSATP6AP2No-1UBC
SMSIGBP1No-1UBC
SMSTAF1No-1UBC
SMSRBMXNo-1UBC
SMSUBE2ANo-1UBC
SMSCUL4BNo-1UBC
SMSPHF6No-1UBC
SMSZDHHC9No-1UBC
NONOATP6AP2No-1UBC
NONOIGBP1No-1UBC
NONOTAF1No-3UBC, AR, SMARCA4
NONORBMXNo-3FUS, UBC, U2AF2
NONOUBE2ANo-1UBC
NONOCUL4BNo-1UBC
NONOPHF6No-1UBC
NONOZDHHC9No-1UBC
CASKGRIA3No-1DLG4
ATP6AP2IGBP1No-1UBC
ATP6AP2TAF1No-1UBC
ATP6AP2RBMXNo-1UBC
ATP6AP2UBE2ANo-1UBC
ATP6AP2CUL4BNo-1UBC
ATP6AP2PHF6No-1UBC
ATP6AP2ZDHHC9No-1UBC
IGBP1TAF1No-1UBC
IGBP1RBMXNo-1UBC
IGBP1UBE2ANo-1UBC
IGBP1CUL4BNo-1UBC
IGBP1PHF6No-1UBC
IGBP1ZDHHC9No-1UBC
TAF1RBMXNo-15POLR2I, POLR2A, POLR2J, POLR2D, POLR2F, POLR2B, POLR2L, GTF2F1, POLR2H, UBC, POLR2E, POLR2C, POLR2G, GTF2F2, POLR2K
TAF1UBE2ANo-3UBC, TP53, MDM2
TAF1CUL4BNo-1UBC
TAF1PHF6No-1UBC
TAF1ZDHHC9No-1UBC
ARXUBE2ANo-1SAE1
RBMXUBE2ANo-1UBC
RBMXCUL4BNo-1UBC
RBMXPHF6No-1UBC
RBMXZDHHC9No-1UBC
UBE2ACUL4BYesbinding2UBC, CDK2
UBE2APHF6No-1UBC
UBE2AZDHHC9No-1UBC
CUL4BPHF6No-1UBC
CUL4BZDHHC9No-1UBC
PHF6ZDHHC9No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
UPF3BRBMXNo-5RBM8A, SRRM1, MAGOH, EIF4A3, ALYREF
HUWE1NONONo-1NPM1
NONOTAF1No-1HSPA4
NONORBMXNo-3DDX5, SNRPA, SFPQ
MECP2TAF1No-4SIN3A, HDAC1, HDAC2, SMARCA2
TAF1RBMXNo-1EFTUD2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SMSIGBP1No1NUDCD2
PRPS1UBE2ANo1TWF1
NONOPQBP1No2SCO2, ZC3H11A
NONORBMXNo2RRM2, HNRNPM
IGBP1UBE2ANo6UNK, UBQLN2, TYMS, POMP, PRDX5, ZFYVE19
PQBP1RBMXNo1RPS28

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.493SMS, PRPS1, HSD17B10
Ubiquitin mediated proteolysishsa041205.633HUWE1, UBE2A, CUL4B
Spliceosomehsa030405.732PQBP1, RBMX
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Gene ExpressionR-HSA-741602.723UPF3B, RBMX, TAF1
Immune SystemR-HSA-1682562.373UBE2A, HUWE1, AP1S2
MetabolismR-HSA-14307282.343SMS, PRPS1, HSD17B10
Chromatin organizationR-HSA-48397265.193HDAC8, KDM5C, PHF8
Adaptive Immune SystemR-HSA-12802183.193UBE2A, HUWE1, AP1S2
DiseaseR-HSA-16436853.333HDAC8, AP1S2, TAF1
Chromatin modifying enzymesR-HSA-32475095.193HDAC8, KDM5C, PHF8
Infectious diseaseR-HSA-56632054.472AP1S2, TAF1
HDMs demethylate histonesR-HSA-32148428.42KDM5C, PHF8
mRNA Splicing - Major PathwayR-HSA-721636.152UPF3B, RBMX
mRNA SplicingR-HSA-721726.152UPF3B, RBMX
M PhaseR-HSA-688864.872HDAC8, PHF8
Processing of Capped Intron-Containing Pre-mRNAR-HSA-722036.12UPF3B, RBMX
HIV InfectionR-HSA-1629065.222AP1S2, TAF1
Neuronal SystemR-HSA-1123164.822GRIA3, CASK
Class I MHC mediated antigen processing & presentationR-HSA-9831694.652UBE2A, HUWE1
Antigen processing: Ubiquitination & Proteasome degradationR-HSA-9831685.192UBE2A, HUWE1
Cell Cycle, MitoticR-HSA-692784.162HDAC8, PHF8
Transmembrane transport of small moleculesR-HSA-3825513.792SLC9A6, CLIC2
Metabolism of amino acids and derivativesR-HSA-712915.42SMS, HSD17B10
Cell CycleR-HSA-16401703.892HDAC8, PHF8
Transmission across Chemical SynapsesR-HSA-1123155.282GRIA3, CASK
Signal TransductionR-HSA-1625821.782HDAC8, FGD1
RNA Polymerase II TranscriptionR-HSA-738576.252UPF3B, TAF1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1824ATP6AP2, PRPS1, HSD17B10, KDM5C, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, PHF8, CLIC2, FGD1, TAF1, IGBP1, PHF6, ZDHHC9, HUWE1, UPF3B, AP1S2, CASK
protein binding (GO:0005515) 0.4620HDAC8, ATP6AP2, MECP2, NONO, PRPS1, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, FGD1, UPF3B, AP1S2, TAF1, CASK, PHF6, PQBP1, IGBP1, CLIC2, PHF8
organic cyclic compound binding (GO:0097159) 1.0516UPF3B, PRPS1, CASK, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, MECP2, RAB40AL, TAF1, ARX, NONO, PQBP1, KDM5C, PHF6
heterocyclic compound binding (GO:1901363) 1.0616UPF3B, PRPS1, CASK, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, TAF1, RAB40AL, MECP2, ARX, NONO, PQBP1, KDM5C, PHF6
catalytic activity (GO:0003824) 1.0514HDAC8, ATP6AP2, PRPS1, HSD17B10, ZDHHC9, CUL4B, CLIC2, HUWE1, TAF1, CASK, KDM5C, UBE2A, SMS, PHF8
nucleic acid binding (GO:0003676) 1.4412KDM5C, HSD17B10, RBMX, CUL4B, HUWE1, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6
small molecule binding (GO:0036094) 1.8910UPF3B, PRPS1, HSD17B10, RBMX, UBE2A, MECP2, RAB40AL, TAF1, CASK, NONO
DNA binding (GO:0003677) 1.9210KDM5C, RBMX, CUL4B, HUWE1, MECP2, TAF1, ARX, NONO, PQBP1, PHF6
nucleoside phosphate binding (GO:1901265) 1.9610UPF3B, PRPS1, HSD17B10, RBMX, UBE2A, MECP2, RAB40AL, TAF1, CASK, NONO
nucleotide binding (GO:0000166) 1.9610UPF3B, MECP2, PRPS1, HSD17B10, RBMX, UBE2A, TAF1, RAB40AL, NONO, CASK
transferase activity (GO:0016740) 1.959PRPS1, ZDHHC9, CUL4B, CLIC2, HUWE1, TAF1, CASK, UBE2A, SMS
macromolecular complex binding (GO:0044877) 2.618RBMX, MECP2, PHF6, NONO, ARX, PQBP1, IGBP1, PHF8
cation binding (GO:0043169) 1.47HDAC8, PRPS1, ZDHHC9, KDM5C, FGD1, PHF6, PHF8
poly(A) RNA binding (GO:0044822) 2.697HSD17B10, RBMX, HUWE1, MECP2, UPF3B, NONO, PHF6
enzyme binding (GO:0019899) 2.277ATP6AP2, UBE2A, CUL4B, MECP2, FGD1, IGBP1, PHF6
ion binding (GO:0043167) 1.367HDAC8, PRPS1, ZDHHC9, KDM5C, FGD1, PHF6, PHF8
RNA binding (GO:0003723) 2.367HSD17B10, RBMX, HUWE1, MECP2, UPF3B, NONO, PHF6
metal ion binding (GO:0046872) 1.417HDAC8, PRPS1, ZDHHC9, KDM5C, FGD1, PHF6, PHF8
carbohydrate derivative binding (GO:0097367) 2.035RAB40AL, UBE2A, PRPS1, CASK, TAF1
transporter activity (GO:0005215) 2.575UPF3B, AP1S2, SLC9A6, GRIA3, CLIC2
purine ribonucleoside triphosphate binding (GO:0035639) 2.225RAB40AL, UBE2A, PRPS1, TAF1, CASK
purine nucleoside binding (GO:0001883) 2.225RAB40AL, UBE2A, PRPS1, TAF1, CASK
ribonucleoside binding (GO:0032549) 2.225RAB40AL, UBE2A, PRPS1, TAF1, CASK
purine ribonucleotide binding (GO:0032555) 2.25RAB40AL, UBE2A, PRPS1, CASK, TAF1
purine nucleotide binding (GO:0017076) 2.195RAB40AL, UBE2A, PRPS1, TAF1, CASK
chromatin binding (GO:0003682) 3.645MECP2, PHF8, ARX, NONO, RBMX
purine ribonucleoside binding (GO:0032550) 2.225RAB40AL, UBE2A, PRPS1, CASK, TAF1
ribonucleotide binding (GO:0032553) 2.195RAB40AL, UBE2A, PRPS1, CASK, TAF1
nucleoside binding (GO:0001882) 2.215RAB40AL, UBE2A, PRPS1, TAF1, CASK
transcription regulatory region DNA binding (GO:0044212) 3.034TAF1, NONO, ARX, RBMX
substrate-specific transporter activity (GO:0022892) 2.724GRIA3, AP1S2, SLC9A6, CLIC2
transition metal ion binding (GO:0046914) 2.484KDM5C, PHF8, PHF6, ZDHHC9
sequence-specific DNA binding (GO:0043565) 2.794MECP2, NONO, ARX, TAF1
adenyl nucleotide binding (GO:0030554) 2.44UBE2A, PRPS1, CASK, TAF1
regulatory region nucleic acid binding (GO:0001067) 3.034TAF1, NONO, ARX, RBMX
adenyl ribonucleotide binding (GO:0032559) 2.414UBE2A, PRPS1, CASK, TAF1
zinc ion binding (GO:0008270) 2.664KDM5C, PHF8, PHF6, ZDHHC9
regulatory region DNA binding (GO:0000975) 3.034TAF1, NONO, ARX, RBMX
ATP binding (GO:0005524) 2.434UBE2A, PRPS1, TAF1, CASK
oxidoreductase activity (GO:0016491) 3.124CLIC2, KDM5C, PHF8, HSD17B10
substrate-specific transmembrane transporter activity (GO:0022891) 2.93GRIA3, SLC9A6, CLIC2
ubiquitin-like protein transferase activity (GO:0019787) 3.693CUL4B, UBE2A, HUWE1
histone binding (GO:0042393) 4.723TAF1, PHF8, PHF6
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773PRPS1, TAF1, CASK
transcription factor binding (GO:0008134) 3.463HDAC8, TAF1, MECP2
kinase activity (GO:0016301) 2.933PRPS1, CASK, TAF1
transcription cofactor activity (GO:0003712) 3.443PQBP1, TAF1, MECP2
ion transmembrane transporter activity (GO:0015075) 3.043GRIA3, SLC9A6, CLIC2
transmembrane transporter activity (GO:0022857) 2.823GRIA3, SLC9A6, CLIC2
transcription factor activity, transcription factor binding (GO:0000989) 3.363PQBP1, TAF1, MECP2
transcription factor activity, protein binding (GO:0000988) 3.353PQBP1, TAF1, MECP2
double-stranded DNA binding (GO:0003690) 3.093MECP2, NONO, ARX
ubiquitin-protein transferase activity (GO:0004842) 3.733HUWE1, UBE2A, CUL4B
identical protein binding (GO:0042802) 2.633PRPS1, HSD17B10, NONO
mRNA binding (GO:0003729) 4.683UPF3B, RBMX, MECP2
ubiquitin-like protein ligase binding (GO:0044389) 4.152UBE2A, CUL4B
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362ARX, NONO
enhancer sequence-specific DNA binding (GO:0001158) 5.362ARX, NONO
molecular transducer activity (GO:0060089) 2.322GRIA3, ATP6AP2
nucleic acid binding transcription factor activity (GO:0001071) 2.652MECP2, ARX
receptor activity (GO:0004872) 2.322GRIA3, ATP6AP2
molecular function regulator (GO:0098772) 2.512IGBP1, FGD1
sequence-specific double-stranded DNA binding (GO:1990837) 3.22ARX, NONO
transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765) 5.582CLIC2, SMS
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706) 5.952KDM5C, PHF8
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705) 4.652KDM5C, PHF8
transcription coactivator activity (GO:0003713) 4.042PQBP1, TAF1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652MECP2, ARX
guanyl ribonucleotide binding (GO:0032561) 3.732RAB40AL, PRPS1
transferase activity, transferring acyl groups (GO:0016746) 4.22TAF1, ZDHHC9
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747) 4.372TAF1, ZDHHC9
protein kinase activity (GO:0004672) 3.272CASK, TAF1
ribonucleoprotein complex binding (GO:0043021) 5.152PQBP1, PHF6
passive transmembrane transporter activity (GO:0022803) 3.62GRIA3, CLIC2
histone deacetylase binding (GO:0042826) 5.082MECP2, PHF6
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980) 5.582ARX, NONO
ion channel activity (GO:0005216) 3.712GRIA3, CLIC2
demethylase activity (GO:0032451) 6.212KDM5C, PHF8
protein domain specific binding (GO:0019904) 3.322IGBP1, MECP2
core promoter binding (GO:0001047) 4.712RBMX, NONO
ubiquitin protein ligase activity (GO:0061630) 4.472UBE2A, CUL4B
ubiquitin-like protein ligase activity (GO:0061659) 4.442UBE2A, CUL4B
protein serine/threonine kinase activity (GO:0004674) 3.642TAF1, CASK
ubiquitin protein ligase binding (GO:0031625) 4.172UBE2A, CUL4B
dioxygenase activity (GO:0051213) 5.252KDM5C, PHF8
gated channel activity (GO:0022836) 3.962GRIA3, CLIC2
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082CASK, TAF1
guanyl nucleotide binding (GO:0019001) 3.732RAB40AL, PRPS1
histone demethylase activity (GO:0032452) 6.482KDM5C, PHF8
channel activity (GO:0015267) 3.62GRIA3, CLIC2
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242NONO, ARX
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372ARX, NONO
receptor binding (GO:0005102) 2.432CASK, HSD17B10
substrate-specific channel activity (GO:0022838) 3.672GRIA3, CLIC2
enhancer binding (GO:0035326) 5.212ARX, NONO

NET-GE enrichment

Term New enriched termICP valueGenes
histone demethylase activity (H4-K20 specific) (GO:0035575) NEW9.050.01PHF8, TAF1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2626ATP6AP2, PRPS1, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF6, GRIA3, CLIC2, FGD1, TAF1, IGBP1, PHF8, ZDHHC9, HUWE1, UPF3B, CASK
biological regulation (GO:0065007) 0.3923ATP6AP2, KDM5C, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF8, GRIA3, CLIC2, FGD1, TAF1, IGBP1, PHF6, HUWE1, UPF3B, AP1S2, CASK
regulation of biological process (GO:0050789) 0.4523ATP6AP2, KDM5C, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF8, GRIA3, CLIC2, FGD1, TAF1, IGBP1, PHF6, HUWE1, UPF3B, AP1S2, CASK
regulation of cellular process (GO:0050794) 0.523ATP6AP2, KDM5C, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF8, GRIA3, CLIC2, FGD1, TAF1, IGBP1, PHF6, HUWE1, UPF3B, AP1S2, CASK
organic substance metabolic process (GO:0071704) 0.6322ATP6AP2, PRPS1, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, PHF8, CLIC2, TAF1, PHF6, ZDHHC9, HUWE1, UPF3B, CASK
metabolic process (GO:0008152) 0.5822ATP6AP2, PRPS1, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, PHF8, CLIC2, TAF1, PHF6, ZDHHC9, HUWE1, UPF3B, CASK
cellular metabolic process (GO:0044237) 0.6922ATP6AP2, PRPS1, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, PHF8, CLIC2, TAF1, PHF6, ZDHHC9, HUWE1, UPF3B, CASK
primary metabolic process (GO:0044238) 0.6921HDAC8, UPF3B, MECP2, PRPS1, CASK, HSD17B10, RBMX, CUL4B, SMS, HUWE1, ZDHHC9, TAF1, RAB40AL, ATP6AP2, NONO, ARX, KDM5C, PQBP1, PHF6, UBE2A, PHF8
cellular nitrogen compound metabolic process (GO:0034641) 1.2220HDAC8, ATP6AP2, PRPS1, CASK, HSD17B10, RBMX, CUL4B, CLIC2, HUWE1, TAF1, UPF3B, PHF6, MECP2, ARX, NONO, PQBP1, SMS, UBE2A, PHF8, KDM5C
nitrogen compound metabolic process (GO:0006807) 1.1320HDAC8, ATP6AP2, PRPS1, CASK, HSD17B10, RBMX, CUL4B, CLIC2, HUWE1, TAF1, UPF3B, PHF6, MECP2, ARX, NONO, PQBP1, SMS, UBE2A, PHF8, KDM5C
single-organism process (GO:0044699) 0.4819ATP6AP2, KDM5C, MECP2, PRPS1, ARX, HSD17B10, RBMX, GRIA3, CUL4B, UBE2A, HUWE1, TAF1, SLC9A6, FGD1, CASK, PQBP1, IGBP1, SMS, PHF8
macromolecule metabolic process (GO:0043170) 0.8319HDAC8, ATP6AP2, HSD17B10, ZDHHC9, RBMX, CUL4B, UBE2A, CASK, HUWE1, UPF3B, TAF1, RAB40AL, MECP2, ARX, NONO, PQBP1, PHF6, PHF8, KDM5C
cellular macromolecule metabolic process (GO:0044260) 0.9318HDAC8, UPF3B, HSD17B10, ZDHHC9, RBMX, CUL4B, UBE2A, CASK, HUWE1, TAF1, RAB40AL, MECP2, ARX, NONO, PQBP1, PHF6, PHF8, KDM5C
cellular aromatic compound metabolic process (GO:0006725) 1.317HDAC8, KDM5C, PRPS1, CASK, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, TAF1, UPF3B, MECP2, ARX, NONO, PQBP1, PHF6, PHF8
nucleobase-containing compound metabolic process (GO:0006139) 1.3517HDAC8, KDM5C, PRPS1, CASK, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, TAF1, UPF3B, MECP2, ARX, NONO, PQBP1, PHF6, PHF8
single-organism cellular process (GO:0044763) 0.6517KDM5C, MECP2, PRPS1, CASK, HSD17B10, RBMX, GRIA3, CUL4B, SMS, HUWE1, TAF1, SLC9A6, FGD1, ARX, PQBP1, IGBP1, PHF8
organic cyclic compound metabolic process (GO:1901360) 1.2617HDAC8, KDM5C, PRPS1, CASK, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, TAF1, UPF3B, MECP2, ARX, NONO, PQBP1, PHF6, PHF8
heterocycle metabolic process (GO:0046483) 1.3117HDAC8, KDM5C, PRPS1, CASK, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
regulation of macromolecule metabolic process (GO:0060255) 1.0815HDAC8, ATP6AP2, CASK, RBMX, KDM5C, CUL4B, MECP2, UPF3B, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
nucleic acid metabolic process (GO:0090304) 1.4615HDAC8, KDM5C, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
regulation of primary metabolic process (GO:0080090) 1.0815HDAC8, ATP6AP2, CASK, RBMX, KDM5C, CUL4B, MECP2, UPF3B, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
regulation of metabolic process (GO:0019222) 1.0215HDAC8, ATP6AP2, CASK, RBMX, KDM5C, CUL4B, MECP2, UPF3B, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
positive regulation of biological process (GO:0048518) 1.214ATP6AP2, CASK, RBMX, CUL4B, UBE2A, HUWE1, MECP2, UPF3B, FGD1, ARX, IGBP1, CLIC2, PHF8, TAF1
regulation of cellular metabolic process (GO:0031323) 1.0714HDAC8, ATP6AP2, CASK, RBMX, KDM5C, MECP2, UPF3B, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
organic substance biosynthetic process (GO:1901576) 1.3413HDAC8, PRPS1, RBMX, SMS, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
cellular nitrogen compound biosynthetic process (GO:0044271) 1.5913HDAC8, PRPS1, RBMX, SMS, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
protein metabolic process (GO:0019538) 1.4513HDAC8, ATP6AP2, ZDHHC9, RBMX, CUL4B, UBE2A, HUWE1, MECP2, RAB40AL, TAF1, CASK, KDM5C, PHF8
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.4613HDAC8, CASK, RBMX, KDM5C, MECP2, UPF3B, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
regulation of biosynthetic process (GO:0009889) 1.3713HDAC8, ARX, RBMX, KDM5C, MECP2, UPF3B, PHF6, NONO, CASK, PQBP1, IGBP1, PHF8, TAF1
cellular component organization (GO:0016043) 1.2413HDAC8, KDM5C, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, MECP2, SLC9A6, FGD1, TAF1, PQBP1, PHF8
cellular biosynthetic process (GO:0044249) 1.3713HDAC8, PRPS1, RBMX, SMS, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
biosynthetic process (GO:0009058) 1.3213HDAC8, PRPS1, RBMX, SMS, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
regulation of macromolecule biosynthetic process (GO:0010556) 1.4313HDAC8, ARX, RBMX, KDM5C, MECP2, UPF3B, PHF6, NONO, CASK, PQBP1, IGBP1, PHF8, TAF1
regulation of nitrogen compound metabolic process (GO:0051171) 1.3613HDAC8, CASK, RBMX, KDM5C, MECP2, UPF3B, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
regulation of cellular biosynthetic process (GO:0031326) 1.3813HDAC8, CASK, RBMX, KDM5C, MECP2, UPF3B, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
regulation of gene expression (GO:0010468) 1.3713HDAC8, ARX, RBMX, KDM5C, MECP2, UPF3B, PHF6, NONO, CASK, PQBP1, IGBP1, PHF8, TAF1
cellular component organization or biogenesis (GO:0071840) 1.2213HDAC8, KDM5C, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, MECP2, SLC9A6, FGD1, TAF1, PQBP1, PHF8
positive regulation of cellular process (GO:0048522) 1.313ATP6AP2, RBMX, CUL4B, UBE2A, HUWE1, MECP2, UPF3B, FGD1, TAF1, CASK, IGBP1, CLIC2, PHF8
RNA metabolic process (GO:0016070) 1.5912HDAC8, HSD17B10, RBMX, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.4312HDAC8, CASK, RBMX, KDM5C, MECP2, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
regulation of RNA metabolic process (GO:0051252) 1.5212HDAC8, CASK, RBMX, KDM5C, MECP2, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
regulation of nucleic acid-templated transcription (GO:1903506) 1.5512HDAC8, ARX, RBMX, KDM5C, MECP2, PHF6, NONO, CASK, PQBP1, IGBP1, PHF8, TAF1
regulation of transcription, DNA-templated (GO:0006355) 1.5612HDAC8, ARX, RBMX, KDM5C, MECP2, PHF6, NONO, CASK, PQBP1, IGBP1, PHF8, TAF1
macromolecule modification (GO:0043412) 1.7312HDAC8, KDM5C, ZDHHC9, HSD17B10, CUL4B, UBE2A, HUWE1, MECP2, RAB40AL, TAF1, CASK, PHF8
regulation of RNA biosynthetic process (GO:2001141) 1.5512HDAC8, CASK, RBMX, KDM5C, MECP2, PHF6, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
nucleobase-containing compound biosynthetic process (GO:0034654) 1.7212HDAC8, PRPS1, RBMX, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
aromatic compound biosynthetic process (GO:0019438) 1.712HDAC8, PRPS1, RBMX, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
organic cyclic compound biosynthetic process (GO:1901362) 1.6612HDAC8, PRPS1, RBMX, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
heterocycle biosynthetic process (GO:0018130) 1.712HDAC8, PRPS1, RBMX, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
cellular protein metabolic process (GO:0044267) 1.6311HDAC8, KDM5C, ZDHHC9, CUL4B, UBE2A, HUWE1, MECP2, RAB40AL, TAF1, CASK, PHF8
RNA biosynthetic process (GO:0032774) 1.8411HDAC8, RBMX, KDM5C, MECP2, UPF3B, PHF6, NONO, ARX, PQBP1, TAF1, PHF8
macromolecular complex subunit organization (GO:0043933) 2.1411HDAC8, KDM5C, HSD17B10, RBMX, CUL4B, UBE2A, HUWE1, MECP2, TAF1, PQBP1, PHF8
macromolecule biosynthetic process (GO:0009059) 1.6111HDAC8, RBMX, KDM5C, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
protein modification process (GO:0036211) 1.7911HDAC8, KDM5C, ZDHHC9, CUL4B, UBE2A, HUWE1, MECP2, RAB40AL, TAF1, CASK, PHF8
cellular protein modification process (GO:0006464) 1.7911HDAC8, KDM5C, ZDHHC9, CUL4B, UBE2A, HUWE1, MECP2, RAB40AL, TAF1, CASK, PHF8
developmental process (GO:0032502) 1.3610ATP6AP2, PRPS1, HSD17B10, UBE2A, MECP2, SLC9A6, FGD1, ARX, PQBP1, PHF8
single-organism developmental process (GO:0044767) 1.4910ATP6AP2, PRPS1, HSD17B10, UBE2A, MECP2, SLC9A6, FGD1, ARX, PQBP1, PHF8
negative regulation of cellular process (GO:0048523) 1.4110HDAC8, ARX, CLIC2, KDM5C, MECP2, RBMX, CASK, NONO, IGBP1, PHF8
cellular macromolecule biosynthetic process (GO:0034645) 1.6610HDAC8, RBMX, KDM5C, MECP2, PHF6, NONO, ARX, PQBP1, TAF1, PHF8
negative regulation of biological process (GO:0048519) 1.3310HDAC8, ARX, CLIC2, KDM5C, MECP2, RBMX, CASK, NONO, IGBP1, PHF8
nucleic acid-templated transcription (GO:0097659) 1.9110HDAC8, RBMX, KDM5C, MECP2, PHF6, TAF1, ARX, NONO, PQBP1, PHF8
transcription, DNA-templated (GO:0006351) 1.9110HDAC8, RBMX, KDM5C, MECP2, PHF6, TAF1, ARX, NONO, PQBP1, PHF8
response to stimulus (GO:0050896) 1.229RBMX, GRIA3, CUL4B, UBE2A, HUWE1, MECP2, TAF1, NONO, IGBP1
regulation of response to stimulus (GO:0048583) 1.549ATP6AP2, CLIC2, AP1S2, TAF1, SLC9A6, FGD1, NONO, CASK, IGBP1
positive regulation of metabolic process (GO:0009893) 1.749ARX, RBMX, CUL4B, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
positive regulation of macromolecule metabolic process (GO:0010604) 1.819ARX, RBMX, CUL4B, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
chromatin organization (GO:0006325) 3.288HDAC8, KDM5C, HUWE1, UBE2A, CUL4B, MECP2, TAF1, PHF8
regulation of cellular component organization (GO:0051128) 2.018HDAC8, CUL4B, HUWE1, MECP2, FGD1, TAF1, PQBP1, PHF8
positive regulation of gene expression (GO:0010628) 2.358ARX, RBMX, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
histone modification (GO:0016570) 3.918HDAC8, KDM5C, HUWE1, UBE2A, CUL4B, MECP2, TAF1, PHF8
regulation of signaling (GO:0023051) 1.728ATP6AP2, CLIC2, MECP2, SLC9A6, FGD1, TAF1, NONO, IGBP1
regulation of cell communication (GO:0010646) 1.738ATP6AP2, CLIC2, MECP2, SLC9A6, FGD1, TAF1, NONO, IGBP1
covalent chromatin modification (GO:0016569) 3.898HDAC8, KDM5C, HUWE1, UBE2A, CUL4B, MECP2, TAF1, PHF8
cellular component assembly (GO:0022607) 2.147HSD17B10, RBMX, CUL4B, MECP2, FGD1, TAF1, PQBP1
negative regulation of metabolic process (GO:0009892) 1.937HDAC8, RBMX, KDM5C, MECP2, NONO, ARX, IGBP1
positive regulation of biosynthetic process (GO:0009891) 2.297RBMX, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
positive regulation of cellular metabolic process (GO:0031325) 1.817RBMX, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
negative regulation of cellular metabolic process (GO:0031324) 2.017HDAC8, RBMX, KDM5C, NONO, MECP2, ARX, IGBP1
negative regulation of gene expression (GO:0010629) 2.487HDAC8, RBMX, KDM5C, MECP2, NONO, ARX, IGBP1
single-organism metabolic process (GO:0044710) 1.637PRPS1, HSD17B10, SMS, KDM5C, MECP2, CASK, PHF8
negative regulation of macromolecule metabolic process (GO:0010605) 2.017HDAC8, RBMX, KDM5C, NONO, MECP2, ARX, IGBP1
regulation of signal transduction (GO:0009966) 1.847ATP6AP2, CLIC2, TAF1, SLC9A6, FGD1, NONO, IGBP1
cellular developmental process (GO:0048869) 1.827HSD17B10, HUWE1, RBMX, SLC9A6, MECP2, ARX, PQBP1
positive regulation of cellular biosynthetic process (GO:0031328) 2.37RBMX, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
regulation of protein metabolic process (GO:0051246) 1.937HDAC8, ATP6AP2, CUL4B, MECP2, UPF3B, TAF1, IGBP1
regulation of biological quality (GO:0065008) 1.687HDAC8, ATP6AP2, CLIC2, MECP2, SLC9A6, FGD1, CASK
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.557HDAC8, RBMX, KDM5C, NONO, MECP2, ARX, IGBP1
transport (GO:0006810) 1.517GRIA3, CLIC2, AP1S2, MECP2, UPF3B, SLC9A6, CASK
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.477HDAC8, RBMX, KDM5C, MECP2, NONO, ARX, IGBP1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.297RBMX, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
establishment of localization (GO:0051234) 1.487GRIA3, CLIC2, AP1S2, MECP2, UPF3B, SLC9A6, CASK
localization (GO:0051179) 1.47GRIA3, CLIC2, AP1S2, MECP2, UPF3B, SLC9A6, CASK
organonitrogen compound metabolic process (GO:1901564) 2.327ATP6AP2, PRPS1, HSD17B10, CLIC2, MECP2, CASK, SMS
negative regulation of RNA metabolic process (GO:0051253) 2.667HDAC8, RBMX, KDM5C, NONO, MECP2, ARX, IGBP1
anatomical structure development (GO:0048856) 1.587PRPS1, UBE2A, MECP2, SLC9A6, FGD1, ARX, PHF8
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.397RBMX, MECP2, UPF3B, TAF1, CASK, IGBP1, PHF8
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.247HDAC8, ARX, RBMX, MECP2, TAF1, CASK, IGBP1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.566RBMX, MECP2, TAF1, CASK, IGBP1, PHF8
positive regulation of RNA biosynthetic process (GO:1902680) 2.546RBMX, MECP2, TAF1, CASK, IGBP1, PHF8
cellular response to stimulus (GO:0051716) 1.976RBMX, HUWE1, UBE2A, CUL4B, NONO, TAF1
regulation of cellular protein metabolic process (GO:0032268) 1.996HDAC8, ATP6AP2, MECP2, UPF3B, TAF1, IGBP1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.356RBMX, MECP2, TAF1, CASK, IGBP1, PHF8
negative regulation of biosynthetic process (GO:0009890) 2.476HDAC8, KDM5C, MECP2, NONO, ARX, IGBP1
negative regulation of cellular biosynthetic process (GO:0031327) 2.496HDAC8, KDM5C, MECP2, NONO, ARX, IGBP1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.66HDAC8, KDM5C, MECP2, NONO, ARX, IGBP1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.716HDAC8, KDM5C, MECP2, NONO, ARX, IGBP1
negative regulation of RNA biosynthetic process (GO:1902679) 2.76HDAC8, KDM5C, MECP2, NONO, ARX, IGBP1
response to stress (GO:0006950) 1.86HUWE1, UBE2A, CUL4B, MECP2, TAF1, NONO
negative regulation of transcription, DNA-templated (GO:0045892) 2.756HDAC8, KDM5C, MECP2, NONO, ARX, IGBP1
signal transduction (GO:0007165) 1.286GRIA3, CLIC2, FGD1, RAB40AL, SLC9A6, IGBP1
positive regulation of RNA metabolic process (GO:0051254) 2.516RBMX, MECP2, TAF1, CASK, IGBP1, PHF8
regulation of intracellular signal transduction (GO:1902531) 2.316ATP6AP2, CLIC2, TAF1, FGD1, NONO, IGBP1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.536HDAC8, KDM5C, MECP2, NONO, ARX, IGBP1
positive regulation of transcription, DNA-templated (GO:0045893) 2.566RBMX, MECP2, TAF1, CASK, IGBP1, PHF8
organelle organization (GO:0006996) 2.025HDAC8, PQBP1, CUL4B, FGD1, HSD17B10
macromolecular complex assembly (GO:0065003) 2.555PQBP1, CUL4B, TAF1, HSD17B10, RBMX
multicellular organismal process (GO:0032501) 1.455ATP6AP2, UBE2A, FGD1, MECP2, ARX
cellular response to stress (GO:0033554) 2.515HUWE1, UBE2A, CUL4B, TAF1, NONO
single-multicellular organism process (GO:0044707) 1.785ATP6AP2, UBE2A, FGD1, MECP2, ARX
cell projection organization (GO:0030030) 3.145PQBP1, SLC9A6, CUL4B, MECP2, FGD1
cell differentiation (GO:0030154) 2.145MECP2, HUWE1, HSD17B10, ARX, RBMX
cellular response to DNA damage stimulus (GO:0006974) 3.175CUL4B, UBE2A, HUWE1, TAF1, NONO
small molecule metabolic process (GO:0044281) 2.385SMS, CASK, PRPS1, HSD17B10, MECP2
regulation of multicellular organismal process (GO:0051239) 1.875PQBP1, ATP6AP2, CLIC2, MECP2, ARX
regulation of localization (GO:0032879) 1.945HDAC8, IGBP1, HUWE1, CLIC2, CASK
RNA processing (GO:0006396) 3.015UPF3B, PQBP1, HSD17B10, NONO, RBMX
positive regulation of cellular component organization (GO:0051130) 2.684CUL4B, HUWE1, TAF1, MECP2
regulation of organelle organization (GO:0033043) 2.724HDAC8, HUWE1, PHF8, MECP2
negative regulation of response to stimulus (GO:0048585) 2.524IGBP1, CASK, CLIC2, NONO
cellular catabolic process (GO:0044248) 2.624UPF3B, UBE2A, CUL4B, HSD17B10
anatomical structure morphogenesis (GO:0009653) 2.534PQBP1, ATP6AP2, SLC9A6, FGD1
regulation of apoptotic process (GO:0042981) 2.54MECP2, IGBP1, FGD1, NONO
organic substance catabolic process (GO:1901575) 2.454UPF3B, UBE2A, CUL4B, HSD17B10
regulation of cell death (GO:0010941) 2.434IGBP1, FGD1, MECP2, NONO
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.124HDAC8, IGBP1, MECP2, ARX
protein modification by small protein conjugation or removal (GO:0070647) 2.954RAB40AL, HUWE1, UBE2A, CUL4B
protein modification by small protein conjugation (GO:0032446) 3.14RAB40AL, HUWE1, UBE2A, CUL4B
regulation of programmed cell death (GO:0043067) 2.494MECP2, IGBP1, FGD1, NONO
regulation of protein modification process (GO:0031399) 2.324HDAC8, ATP6AP2, IGBP1, MECP2
proteolysis (GO:0006508) 2.734ATP6AP2, UBE2A, CUL4B, RBMX
RNA splicing (GO:0008380) 3.854UPF3B, PQBP1, RBMX, NONO
regulation of cell proliferation (GO:0042127) 2.414UBE2A, CASK, MECP2, ARX
DNA repair (GO:0006281) 3.594HUWE1, UBE2A, CUL4B, NONO
regulation of developmental process (GO:0050793) 2.14PQBP1, FGD1, MECP2, ARX
ion transport (GO:0006811) 2.664GRIA3, SLC9A6, CLIC2, CASK
RNA splicing, via transesterification reactions (GO:0000375) 4.254UPF3B, PQBP1, RBMX, NONO
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) 4.274UPF3B, PQBP1, RBMX, NONO
response to chemical (GO:0042221) 1.984GRIA3, IGBP1, RBMX, MECP2
catabolic process (GO:0009056) 2.384UPF3B, UBE2A, CUL4B, HSD17B10
oxidation-reduction process (GO:0055114) 2.914KDM5C, PHF8, MECP2, HSD17B10
mRNA metabolic process (GO:0016071) 3.334UPF3B, PQBP1, RBMX, NONO
organic acid metabolic process (GO:0006082) 3.014SMS, PRPS1, HSD17B10, MECP2
regulation of response to stress (GO:0080134) 2.534AP1S2, IGBP1, CASK, NONO
mRNA splicing, via spliceosome (GO:0000398) 4.274UPF3B, PQBP1, RBMX, NONO
protein ubiquitination (GO:0016567) 3.284RAB40AL, HUWE1, UBE2A, CUL4B
phosphate-containing compound metabolic process (GO:0006796) 2.164TAF1, PRPS1, CASK, MECP2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.814IGBP1, TAF1, CASK, RBMX
phosphorus metabolic process (GO:0006793) 2.154CASK, PRPS1, TAF1, MECP2
DNA metabolic process (GO:0006259) 3.094HUWE1, UBE2A, CUL4B, NONO
chromatin modification (GO:0016568) 4.064HDAC8, UBE2A, KDM5C, PHF8
mRNA processing (GO:0006397) 3.694UPF3B, PQBP1, RBMX, NONO
regulation of chromosome organization (GO:0033044) 4.113HDAC8, PHF8, MECP2
regulation of cellular localization (GO:0060341) 3.033HDAC8, CLIC2, HUWE1
regulation of transport (GO:0051049) 2.243CLIC2, HUWE1, CASK
cellular macromolecular complex assembly (GO:0034622) 3.183PQBP1, CUL4B, TAF1
negative regulation of signaling (GO:0023057) 2.653IGBP1, CLIC2, NONO
response to light stimulus (GO:0009416) 4.083UBE2A, CUL4B, MECP2
negative regulation of cell communication (GO:0010648) 2.663IGBP1, CLIC2, NONO
neuron projection development (GO:0031175) 4.583PQBP1, CUL4B, MECP2
multicellular organism development (GO:0007275) 2.543UBE2A, FGD1, ARX
cell cycle (GO:0007049) 3.143CUL4B, TAF1, PHF8
protein acylation (GO:0043543) 4.653TAF1, MECP2, ZDHHC9
negative regulation of protein metabolic process (GO:0051248) 2.823HDAC8, IGBP1, MECP2
cellular macromolecule catabolic process (GO:0044265) 3.193UPF3B, UBE2A, CUL4B
negative regulation of signal transduction (GO:0009968) 2.753IGBP1, CLIC2, NONO
positive regulation of multicellular organismal process (GO:0051240) 2.493ATP6AP2, MECP2, ARX
positive regulation of protein metabolic process (GO:0051247) 2.433UPF3B, CUL4B, TAF1
peptidyl-amino acid modification (GO:0018193) 2.983TAF1, MECP2, ZDHHC9
macromolecule catabolic process (GO:0009057) 3.03UPF3B, UBE2A, CUL4B
histone ubiquitination (GO:0016574) 6.23CUL4B, UBE2A, HUWE1
animal organ development (GO:0048513) 2.533PRPS1, PHF8, MECP2
response to radiation (GO:0009314) 3.693UBE2A, CUL4B, MECP2
regulation of molecular function (GO:0065009) 1.783CLIC2, IGBP1, FGD1
negative regulation of programmed cell death (GO:0043069) 3.023IGBP1, MECP2, NONO
negative regulation of cell death (GO:0060548) 2.953IGBP1, MECP2, NONO
organic substance transport (GO:0071702) 2.153UPF3B, AP1S2, MECP2
phosphorylation (GO:0016310) 2.633PRPS1, TAF1, CASK
negative regulation of apoptotic process (GO:0043066) 3.043IGBP1, MECP2, NONO
ion transmembrane transport (GO:0034220) 3.083GRIA3, SLC9A6, CLIC2
single-organism transport (GO:0044765) 2.183SLC9A6, CASK, MECP2
establishment of localization in cell (GO:0051649) 2.473UPF3B, AP1S2, CASK
negative regulation of intracellular signal transduction (GO:1902532) 3.633IGBP1, CLIC2, NONO
response to organic substance (GO:0010033) 2.23IGBP1, RBMX, MECP2
single-organism localization (GO:1902578) 2.093SLC9A6, CASK, MECP2
response to abiotic stimulus (GO:0009628) 2.83UBE2A, CUL4B, MECP2
negative regulation of cellular protein metabolic process (GO:0032269) 2.883HDAC8, IGBP1, MECP2
transmembrane transport (GO:0055085) 2.723GRIA3, SLC9A6, CLIC2
negative regulation of protein modification process (GO:0031400) 3.43HDAC8, IGBP1, MECP2
regulation of cellular component biogenesis (GO:0044087) 3.083CUL4B, TAF1, MECP2
organophosphate metabolic process (GO:0019637) 3.043PRPS1, CASK, MECP2
system development (GO:0048731) 2.923PRPS1, MECP2, ARX
positive regulation of cellular component biogenesis (GO:0044089) 3.713CUL4B, TAF1, MECP2
negative regulation of apoptotic signaling pathway (GO:2001234) 4.422IGBP1, NONO
protein localization (GO:0008104) 2.362AP1S2, MECP2
regulation of phosphate metabolic process (GO:0019220) 2.352ATP6AP2, IGBP1
regulation of apoptotic signaling pathway (GO:2001233) 3.832IGBP1, NONO
protein acetylation (GO:0006473) 4.862TAF1, MECP2
internal protein amino acid acetylation (GO:0006475) 4.992TAF1, MECP2
regulation of homeostatic process (GO:0032844) 3.652HDAC8, CLIC2
purine ribonucleoside monophosphate metabolic process (GO:0009167) 4.72PRPS1, CASK
regulation of neuron apoptotic process (GO:0043523) 4.472MECP2, NONO
negative regulation of neuron apoptotic process (GO:0043524) 4.822MECP2, NONO
cell surface receptor signaling pathway (GO:0007166) 2.092GRIA3, SLC9A6
ribonucleoside monophosphate metabolic process (GO:0009161) 4.622PRPS1, CASK
histone H2A ubiquitination (GO:0033522) 6.962UBE2A, CUL4B
regulation of gene expression, epigenetic (GO:0040029) 4.582PHF8, MECP2
rhythmic process (GO:0048511) 4.022KDM5C, NONO
positive regulation of molecular function (GO:0044093) 2.232CLIC2, FGD1
negative regulation of molecular function (GO:0044092) 2.742IGBP1, CLIC2
macromolecule localization (GO:0033036) 2.342AP1S2, MECP2
(GO:1905268) 5.92PHF8, MECP2
regulation of phosphorylation (GO:0042325) 2.52ATP6AP2, IGBP1
regulation of DNA metabolic process (GO:0051052) 3.872HDAC8, MECP2
positive regulation of transport (GO:0051050) 2.92HUWE1, CASK
regulation of protein complex assembly (GO:0043254) 3.832CUL4B, TAF1
protein-DNA complex assembly (GO:0065004) 4.62CUL4B, TAF1
single organism reproductive process (GO:0044702) 2.732UBE2A, HSD17B10
regulation of proteolysis (GO:0030162) 3.22IGBP1, TAF1
oxoacid metabolic process (GO:0043436) 3.122SMS, MECP2
purine ribonucleoside metabolic process (GO:0046128) 4.332PRPS1, CASK
regulation of calcium ion import (GO:0090279) 5.082CLIC2, CASK
multi-organism process (GO:0051704) 2.652TAF1, MECP2
demethylation (GO:0070988) 5.742KDM5C, PHF8
single organism signaling (GO:0044700) 3.252GRIA3, MECP2
regulation of protein localization (GO:0032880) 2.882HDAC8, HUWE1
cellular biogenic amine metabolic process (GO:0006576) 5.922SMS, MECP2
organonitrogen compound biosynthetic process (GO:1901566) 2.852SMS, PRPS1
peptidyl-lysine modification (GO:0018205) 3.982TAF1, MECP2
negative regulation of organelle organization (GO:0010639) 4.072PHF8, MECP2
purine nucleotide metabolic process (GO:0006163) 4.092PRPS1, CASK
anterograde trans-synaptic signaling (GO:0098916) 3.982GRIA3, MECP2
signaling (GO:0023052) 3.252GRIA3, MECP2
positive regulation of catabolic process (GO:0009896) 3.942CUL4B, TAF1
regulation of catabolic process (GO:0009894) 3.522CUL4B, TAF1
regulation of anatomical structure morphogenesis (GO:0022603) 2.792PQBP1, FGD1
secretion by cell (GO:0032940) 3.592CASK, MECP2
synapse organization (GO:0050808) 4.872SLC9A6, MECP2
intracellular signal transduction (GO:0035556) 2.392RAB40AL, CLIC2
response to cytokine (GO:0034097) 3.842IGBP1, RBMX
immune system process (GO:0002376) 2.292IGBP1, AP1S2
protein polyubiquitination (GO:0000209) 4.232UBE2A, HUWE1
histone demethylation (GO:0016577) 6.432KDM5C, PHF8
histone acetylation (GO:0016573) 5.092TAF1, MECP2
transcription from RNA polymerase II promoter (GO:0006366) 3.382RBMX, TAF1
methylation (GO:0032259) 4.062HSD17B10, MECP2
internal peptidyl-lysine acetylation (GO:0018393) 5.052TAF1, MECP2
lipid metabolic process (GO:0006629) 2.682HSD17B10, MECP2
amine metabolic process (GO:0009308) 5.742SMS, MECP2
peptidyl-lysine acetylation (GO:0018394) 5.032TAF1, MECP2
cation transport (GO:0006812) 3.112SLC9A6, CASK
regulation of catalytic activity (GO:0050790) 1.972IGBP1, FGD1
purine ribonucleotide metabolic process (GO:0009150) 4.162PRPS1, CASK
macromolecule methylation (GO:0043414) 4.422MECP2, HSD17B10
regulation of neuron death (GO:1901214) 4.192MECP2, NONO
negative regulation of neuron death (GO:1901215) 4.572MECP2, NONO
regulation of hydrolase activity (GO:0051336) 2.532IGBP1, FGD1
proteolysis involved in cellular protein catabolic process (GO:0051603) 3.592UBE2A, CUL4B
secretion (GO:0046903) 3.382CASK, MECP2
brain development (GO:0007420) 4.242PHF8, MECP2
intracellular transport (GO:0046907) 2.672UPF3B, AP1S2
regulation of cellular response to stress (GO:0080135) 3.42IGBP1, NONO
inorganic ion transmembrane transport (GO:0098660) 3.382SLC9A6, CLIC2
protein monoubiquitination (GO:0006513) 5.82CUL4B, HUWE1
ubiquitin-dependent protein catabolic process (GO:0006511) 3.722UBE2A, CUL4B
cellular amide metabolic process (GO:0043603) 3.232ATP6AP2, CLIC2
peptide metabolic process (GO:0006518) 3.442ATP6AP2, CLIC2
nucleoside phosphate metabolic process (GO:0006753) 3.712PRPS1, CASK
synaptic signaling (GO:0099536) 3.982GRIA3, MECP2
trans-synaptic signaling (GO:0099537) 3.982GRIA3, MECP2
regulation of cell morphogenesis (GO:0022604) 3.42PQBP1, FGD1
purine nucleoside metabolic process (GO:0042278) 4.322PRPS1, CASK
regulation of response to external stimulus (GO:0032101) 3.062AP1S2, CASK
negative regulation of cellular component organization (GO:0051129) 3.352PHF8, MECP2
regulation of cellular protein localization (GO:1903827) 3.432HDAC8, HUWE1
regulation of protein catabolic process (GO:0042176) 3.832CUL4B, TAF1
response to UV (GO:0009411) 4.882UBE2A, CUL4B
regulation of phosphorus metabolic process (GO:0051174) 2.352ATP6AP2, IGBP1
nucleoside monophosphate metabolic process (GO:0009123) 4.542PRPS1, CASK
positive regulation of cell communication (GO:0010647) 2.412ATP6AP2, MECP2
purine nucleoside monophosphate metabolic process (GO:0009126) 4.692PRPS1, CASK
ribonucleotide metabolic process (GO:0009259) 4.112PRPS1, CASK
regulation of MAPK cascade (GO:0043408) 3.222ATP6AP2, IGBP1
regulation of neurogenesis (GO:0050767) 3.212PQBP1, MECP2
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292SLC9A6, CASK
regulation of system process (GO:0044057) 3.532CLIC2, MECP2
regulation of RNA splicing (GO:0043484) 5.152PQBP1, RBMX
regulation of cell cycle process (GO:0010564) 3.52HDAC8, CUL4B
regulation of cell development (GO:0060284) 3.012PQBP1, MECP2
positive regulation of cellular protein metabolic process (GO:0032270) 2.492UPF3B, TAF1
alpha-amino acid metabolic process (GO:1901605) 4.52SMS, MECP2
positive regulation of cell proliferation (GO:0008284) 3.012UBE2A, MECP2
positive regulation of protein complex assembly (GO:0031334) 4.442CUL4B, TAF1
cellular amine metabolic process (GO:0044106) 5.922SMS, MECP2
regulation of cell differentiation (GO:0045595) 2.422PQBP1, MECP2
metal ion transport (GO:0030001) 3.362SLC9A6, CASK
nucleobase-containing small molecule metabolic process (GO:0055086) 3.592PRPS1, CASK
chromosome organization (GO:0051276) 3.792HDAC8, CUL4B
protein oligomerization (GO:0051259) 3.712RBMX, HSD17B10
histone lysine demethylation (GO:0070076) 6.552KDM5C, PHF8
positive regulation of developmental process (GO:0051094) 2.772MECP2, ARX
carbohydrate derivative metabolic process (GO:1901135) 3.072PRPS1, CASK
regulation of chromatin organization (GO:1902275) 4.692PHF8, MECP2
carboxylic acid metabolic process (GO:0019752) 3.122SMS, MECP2
cell cycle process (GO:0022402) 2.752HDAC8, PHF8
cell cycle phase (GO:0022403) 4.392HDAC8, PHF8
protein dealkylation (GO:0008214) 6.362KDM5C, PHF8
purine-containing compound metabolic process (GO:0072521) 4.02PRPS1, CASK
modification-dependent macromolecule catabolic process (GO:0043632) 3.692UBE2A, CUL4B
regulation of ion transport (GO:0043269) 3.42CLIC2, CASK
protein-DNA complex subunit organization (GO:0071824) 4.452CUL4B, TAF1
protein demethylation (GO:0006482) 6.362KDM5C, PHF8
protein complex subunit organization (GO:0071822) 2.62RBMX, HSD17B10
positive regulation of protein catabolic process (GO:0045732) 4.182CUL4B, TAF1
response to interleukin-1 (GO:0070555) 5.072IGBP1, RBMX
cellular amino acid metabolic process (GO:0006520) 4.222SMS, MECP2
protein homooligomerization (GO:0051260) 4.212RBMX, HSD17B10
cellular component morphogenesis (GO:0032989) 3.52PQBP1, SLC9A6
nitrogen compound transport (GO:0071705) 3.542UPF3B, MECP2
regulation of nervous system development (GO:0051960) 3.12PQBP1, MECP2
protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 4.832CUL4B, HUWE1
protein phosphorylation (GO:0006468) 2.892TAF1, CASK
modification-dependent protein catabolic process (GO:0019941) 3.712UBE2A, CUL4B
protein complex assembly (GO:0006461) 2.782RBMX, HSD17B10
regulation of metal ion transport (GO:0010959) 3.942CLIC2, CASK
reproductive process (GO:0022414) 2.552UBE2A, HSD17B10
biological phase (GO:0044848) 4.372HDAC8, PHF8
cell part morphogenesis (GO:0032990) 3.992PQBP1, SLC9A6
nucleotide metabolic process (GO:0009117) 3.732PRPS1, CASK
nucleoside metabolic process (GO:0009116) 4.122PRPS1, CASK
chemical synaptic transmission (GO:0007268) 3.982GRIA3, MECP2
cell-cell signaling (GO:0007267) 3.352GRIA3, MECP2
cell communication (GO:0007154) 3.042GRIA3, MECP2
ribonucleoside metabolic process (GO:0009119) 4.212PRPS1, CASK
positive regulation of signaling (GO:0023056) 2.412ATP6AP2, MECP2
cellular localization (GO:0051641) 2.322UPF3B, AP1S2
regulation of protein phosphorylation (GO:0001932) 2.572ATP6AP2, IGBP1
cell projection morphogenesis (GO:0048858) 4.052PQBP1, SLC9A6
nervous system development (GO:0007399) 3.532PRPS1, ARX
regulation of cell cycle (GO:0051726) 2.932HDAC8, CUL4B
regulation of calcium ion transport (GO:0051924) 4.382CLIC2, CASK
ribose phosphate metabolic process (GO:0019693) 4.062PRPS1, CASK
glycosyl compound metabolic process (GO:1901657) 4.042PRPS1, CASK
regulation of multicellular organismal development (GO:2000026) 2.312PQBP1, MECP2
negative regulation of chromosome organization (GO:2001251) 5.172PHF8, MECP2

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) -2.550.045HDAC8, ATP6AP2, CASK, RBMX, KDM5C, UBE2A, HUWE1, MECP2, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
chromatin organization (GO:0006325) -3.280.009HDAC8, KDM5C, CUL4B, UBE2A, HUWE1, MECP2, NONO, IGBP1, PHF8, TAF1
negative regulation of RNA metabolic process (GO:0051253) -2.660.014HDAC8, ATP6AP2, CASK, RBMX, KDM5C, UBE2A, HUWE1, MECP2, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) -2.60.036HDAC8, ATP6AP2, CASK, RBMX, KDM5C, UBE2A, HUWE1, MECP2, TAF1, ARX, NONO, PQBP1, IGBP1, PHF8
histone ubiquitination (GO:0016574) -6.20.012CUL4B, UBE2A, HUWE1
cellular nitrogen compound metabolic process (GO:0034641) -1.220.031HDAC8, KDM5C, MECP2, PRPS1, CASK, HSD17B10, RBMX, CUL4B, SMS, HUWE1, TAF1, UPF3B, NONO, ARX, PQBP1, PHF6, UBE2A, PHF8
histone modification (GO:0016570) -3.910.0HDAC8, KDM5C, CUL4B, UBE2A, HUWE1, MECP2, TAF1, NONO, IGBP1, PHF8
histone H4-K20 demethylation (GO:0035574) NEW9.040.038PHF8, TAF1
chromatin modification (GO:0016568) -4.060.0HDAC8, KDM5C, CUL4B, UBE2A, HUWE1, MECP2, TAF1, NONO, IGBP1, PHF8
covalent chromatin modification (GO:0016569) -3.890.0HDAC8, KDM5C, CUL4B, UBE2A, HUWE1, MECP2, TAF1, NONO, IGBP1, PHF8
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1127ATP6AP2, PRPS1, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF6, GRIA3, CLIC2, FGD1, TAF1, IGBP1, PHF8, ZDHHC9, HUWE1, UPF3B, AP1S2, CASK
intracellular part (GO:0044424) 0.2826PRPS1, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF6, GRIA3, CLIC2, FGD1, TAF1, IGBP1, PHF8, ZDHHC9, HUWE1, UPF3B, AP1S2, CASK
organelle (GO:0043226) 0.425ATP6AP2, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF6, GRIA3, CLIC2, FGD1, TAF1, PHF8, ZDHHC9, HUWE1, UPF3B, AP1S2, CASK
intracellular organelle (GO:0043229) 0.5123HSD17B10, KDM5C, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, RAB40AL, SLC9A6, PHF8, GRIA3, CLIC2, FGD1, TAF1, PHF6, ZDHHC9, HUWE1, UPF3B, AP1S2, CASK
membrane-bounded organelle (GO:0043227) 0.4723ATP6AP2, HSD17B10, KDM5C, SMS, MECP2, NONO, ARX, PQBP1, HDAC8, CUL4B, RBMX, RAB40AL, SLC9A6, PHF8, CLIC2, FGD1, TAF1, PHF6, ZDHHC9, HUWE1, UPF3B, AP1S2, CASK
intracellular membrane-bounded organelle (GO:0043231) 0.621HDAC8, UPF3B, ZDHHC9, HSD17B10, RBMX, CUL4B, CLIC2, CASK, HUWE1, AP1S2, TAF1, RAB40AL, SLC9A6, FGD1, MECP2, ARX, NONO, PQBP1, PHF6, PHF8, KDM5C
intracellular organelle part (GO:0044446) 0.8120HDAC8, KDM5C, HSD17B10, ZDHHC9, RBMX, GRIA3, CUL4B, UBE2A, HUWE1, SLC9A6, TAF1, UPF3B, AP1S2, MECP2, CASK, NONO, PQBP1, IGBP1, PHF8, PHF6
organelle part (GO:0044422) 0.7920HDAC8, KDM5C, MECP2, ZDHHC9, HSD17B10, RBMX, GRIA3, CUL4B, UBE2A, HUWE1, AP1S2, NONO, UPF3B, SLC9A6, TAF1, CASK, PHF6, PQBP1, IGBP1, PHF8
cytoplasmic part (GO:0044444) 0.8218HDAC8, RAB40AL, PRPS1, HSD17B10, ZDHHC9, GRIA3, CUL4B, SMS, HUWE1, AP1S2, FGD1, UPF3B, SLC9A6, MECP2, CASK, PQBP1, IGBP1, UBE2A
macromolecular complex (GO:0032991) 1.3515HDAC8, PRPS1, ZDHHC9, RBMX, GRIA3, CLIC2, CUL4B, TAF1, UPF3B, AP1S2, MECP2, NONO, PQBP1, UBE2A, PHF6
nucleus (GO:0005634) 1.0715HDAC8, KDM5C, CASK, RBMX, CUL4B, CLIC2, HUWE1, MECP2, UPF3B, TAF1, ARX, NONO, PQBP1, PHF6, PHF8
nuclear part (GO:0044428) 1.5515HDAC8, KDM5C, RBMX, GRIA3, CUL4B, UBE2A, HUWE1, MECP2, UPF3B, TAF1, CASK, NONO, PQBP1, PHF6, PHF8
cytoplasm (GO:0005737) 1.0114HDAC8, UPF3B, ZDHHC9, HSD17B10, CUL4B, UBE2A, HUWE1, FGD1, RAB40AL, MECP2, CASK, PQBP1, IGBP1, CLIC2
membrane (GO:0016020) 0.6814HDAC8, ATP6AP2, HSD17B10, ZDHHC9, GRIA3, CLIC2, HUWE1, SLC9A6, RBMX, RAB40AL, AP1S2, NONO, CASK, PHF8
protein complex (GO:0043234) 1.5113HDAC8, PRPS1, ZDHHC9, GRIA3, CLIC2, CUL4B, MECP2, UPF3B, AP1S2, TAF1, NONO, UBE2A, PHF6
nucleoplasm (GO:0005654) 1.8912HDAC8, KDM5C, RBMX, GRIA3, CUL4B, HUWE1, NONO, UPF3B, TAF1, PQBP1, PHF6, PHF8
cytosol (GO:0005829) 1.6812HDAC8, PRPS1, CUL4B, UBE2A, HUWE1, MECP2, UPF3B, AP1S2, FGD1, CASK, IGBP1, SMS
non-membrane-bounded organelle (GO:0043228) 1.7610HDAC8, GRIA3, UBE2A, FGD1, UPF3B, NONO, CASK, PQBP1, PHF6, PHF8
intracellular non-membrane-bounded organelle (GO:0043232) 1.7610HDAC8, GRIA3, UBE2A, NONO, UPF3B, FGD1, CASK, PQBP1, PHF6, PHF8
membrane part (GO:0044425) 0.958ATP6AP2, ZDHHC9, GRIA3, CLIC2, HUWE1, AP1S2, SLC9A6, CASK
vesicle (GO:0031982) 1.648ATP6AP2, HUWE1, SMS, CUL4B, AP1S2, RBMX, SLC9A6, CASK
extracellular region part (GO:0044421) 1.577ATP6AP2, HUWE1, SMS, CUL4B, MECP2, RBMX, CASK
integral component of membrane (GO:0016021) 1.146ATP6AP2, ZDHHC9, GRIA3, CLIC2, HUWE1, SLC9A6
plasma membrane (GO:0005886) 1.396ATP6AP2, HDAC8, HSD17B10, GRIA3, SLC9A6, CASK
catalytic complex (GO:1902494) 2.96HDAC8, PRPS1, ZDHHC9, UBE2A, CUL4B, TAF1
intrinsic component of membrane (GO:0031224) 1.136ATP6AP2, ZDHHC9, GRIA3, CLIC2, HUWE1, SLC9A6
organelle membrane (GO:0031090) 1.976ZDHHC9, GRIA3, SLC9A6, AP1S2, CASK, PHF8
extracellular vesicle (GO:1903561) 1.895ATP6AP2, CUL4B, SMS, HUWE1, RBMX
extracellular organelle (GO:0043230) 1.895ATP6AP2, CUL4B, SMS, HUWE1, RBMX
extracellular exosome (GO:0070062) 1.895ATP6AP2, HUWE1, SMS, CUL4B, RBMX
nucleolus (GO:0005730) 3.065UPF3B, CASK, PHF8, NONO, PHF6
bounding membrane of organelle (GO:0098588) 2.395GRIA3, AP1S2, SLC9A6, CASK, ZDHHC9
membrane-bounded vesicle (GO:0031988) 1.715ATP6AP2, CUL4B, SMS, HUWE1, RBMX
neuron part (GO:0097458) 2.645GRIA3, PQBP1, SLC9A6, ATP6AP2, CASK
transferase complex (GO:1990234) 3.325PRPS1, UBE2A, CUL4B, TAF1, ZDHHC9
cell projection (GO:0042995) 2.475GRIA3, PQBP1, SLC9A6, ATP6AP2, FGD1
cell projection part (GO:0044463) 2.974GRIA3, PQBP1, SLC9A6, CASK
chromosomal part (GO:0044427) 3.184UBE2A, MECP2, PHF6, RBMX
nucleoplasm part (GO:0044451) 3.224HDAC8, PQBP1, TAF1, NONO
mitochondrion (GO:0005739) 2.424RAB40AL, SLC9A6, HSD17B10, MECP2
Golgi apparatus (GO:0005794) 2.73AP1S2, FGD1, ZDHHC9
membrane protein complex (GO:0098796) 2.843GRIA3, CLIC2, AP1S2
chromosome (GO:0005694) 3.783HDAC8, UBE2A, PHF6
whole membrane (GO:0098805) 2.853GRIA3, SLC9A6, AP1S2
nuclear chromosome part (GO:0044454) 3.673UBE2A, RBMX, MECP2
nuclear chromatin (GO:0000790) 4.423UBE2A, RBMX, MECP2
cytoskeletal part (GO:0044430) 2.493UPF3B, PQBP1, IGBP1
chromatin (GO:0000785) 3.993UBE2A, RBMX, MECP2
synapse (GO:0045202) 3.583GRIA3, SLC9A6, CASK
neuron projection (GO:0043005) 3.123GRIA3, ATP6AP2, SLC9A6
synapse part (GO:0044456) 3.423GRIA3, CASK, MECP2
plasma membrane part (GO:0044459) 1.953GRIA3, ATP6AP2, CASK
plasma membrane region (GO:0098590) 2.972GRIA3, CASK
nuclear speck (GO:0016607) 4.522PQBP1, NONO
dendrite (GO:0030425) 3.922GRIA3, SLC9A6
endoplasmic reticulum membrane (GO:0005789) 2.952SLC9A6, ZDHHC9
RNA polymerase II transcription factor complex (GO:0090575) 5.182TAF1, NONO
ion channel complex (GO:0034702) 4.182GRIA3, CLIC2
vacuolar membrane (GO:0005774) 3.452SLC9A6, AP1S2
cell junction (GO:0030054) 2.752GRIA3, CASK
synaptic membrane (GO:0097060) 4.222GRIA3, CASK
nuclear body (GO:0016604) 3.942PQBP1, NONO
extracellular space (GO:0005615) 2.632RBMX, MECP2
cytoplasmic vesicle (GO:0031410) 2.872SLC9A6, AP1S2
neuron spine (GO:0044309) 5.042GRIA3, SLC9A6
Golgi apparatus part (GO:0044431) 3.02AP1S2, ZDHHC9
microtubule organizing center (GO:0005815) 3.422UPF3B, PQBP1
cytoplasmic vesicle part (GO:0044433) 3.412GRIA3, AP1S2
endoplasmic reticulum part (GO:0044432) 2.732SLC9A6, ZDHHC9
nuclear transcription factor complex (GO:0044798) 4.952TAF1, NONO
vacuolar part (GO:0044437) 3.262SLC9A6, AP1S2
nuclear matrix (GO:0016363) 5.222CASK, NONO
cytoskeleton (GO:0005856) 2.552CASK, FGD1
transmembrane transporter complex (GO:1902495) 4.062GRIA3, CLIC2
intracellular ribonucleoprotein complex (GO:0030529) 3.192PQBP1, RBMX
cell body (GO:0044297) 3.742GRIA3, ATP6AP2
axon part (GO:0033267) 4.42GRIA3, SLC9A6
transporter complex (GO:1990351) 4.042GRIA3, CLIC2
cytoplasmic vesicle membrane (GO:0030659) 3.672GRIA3, AP1S2
endocytic vesicle membrane (GO:0030666) 4.822GRIA3, AP1S2
intracellular vesicle (GO:0097708) 2.862SLC9A6, AP1S2
vesicle membrane (GO:0012506) 3.632GRIA3, AP1S2
ribonucleoprotein complex (GO:1990904) 3.192PQBP1, RBMX
ubiquitin ligase complex (GO:0000151) 4.232UBE2A, CUL4B
Golgi membrane (GO:0000139) 3.282AP1S2, ZDHHC9
postsynapse (GO:0098794) 4.872GRIA3, MECP2
transcription factor complex (GO:0005667) 4.12TAF1, NONO
ciliary part (GO:0044441) 4.052PQBP1, CASK

NET-GE enrichment

Term New enriched termICP valueGenes
protein complex (GO:0043234) -1.510.006ATP6AP2, HSD17B10, KDM5C, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, CLIC2, FGD1, TAF1, IGBP1, PHF8, ZDHHC9, GRIA4, HUWE1, UPF3B, AP1S2, CASK
chromatin (GO:0000785) -3.990.012RBMX, UBE2A, CUL4B, MECP2, NONO, TAF1, PHF8
chromosomal part (GO:0044427) -3.180.007HDAC8, RBMX, CUL4B, UBE2A, HUWE1, MECP2, TAF1, NONO, IGBP1, PHF8
macromolecular complex (GO:0032991) -1.350.038ATP6AP2, HSD17B10, KDM5C, MECP2, NONO, ARX, PQBP1, HDAC8, UBE2A, CUL4B, RBMX, CLIC2, FGD1, TAF1, IGBP1, PHF8, ZDHHC9, GRIA4, HUWE1, UPF3B, AP1S2, CASK