Disease table of PICK DISEASE OF BRAIN OMIM ID: 172700

Gene-disease associations table

GeneAssociated with PICK DISEASE OF BRAIN inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PSEN1ClinVar, OMIMHGNC link14q24.27607822, 172700, 600274, 104300, PS142690, 606889, PS115200
MAPTClinVar, OMIM, HUMSAVARHGNC link17q21.315PS168600, 600274, 601104, 172700, 260540

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PSEN1YES3SP1, CREB1, ELK10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PSEN1MAPTYes9APOE, MAPT, PSEN1, TRAF6, UBC, TUBA1B, GSK3B, CDK5, APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PSEN1MAPTNo-4UBC, MAPK8, GSK3B, BDNF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Alzheimer's diseasehsa050105.342MAPT, PSEN1

NET-GE enrichment

Term New enriched termICP valueGenes
Neurodegenerative diseasesNEW4.270.032MAPT, PSEN1
Alzheimer's disease (hsa05010) -5.340.007MAPT, PSEN1
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182MAPT, PSEN1
protein binding (GO:0005515) 0.462MAPT, PSEN1
protein domain specific binding (GO:0019904) 3.322MAPT, PSEN1

NET-GE enrichment

Term New enriched termICP valueGenes
SH3 domain binding (GO:0017124) NEW4.980.044MAPT, PSEN1
protein domain specific binding (GO:0019904) -3.320.045MAPT, PSEN1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of cell morphogenesis (GO:0022604) 3.42MAPT, PSEN1
developmental process (GO:0032502) 1.362MAPT, PSEN1
regulation of neuron projection development (GO:0010975) 3.692MAPT, PSEN1
regulation of anatomical structure morphogenesis (GO:0022603) 2.792MAPT, PSEN1
cell differentiation (GO:0030154) 2.142MAPT, PSEN1
behavior (GO:0007610) 3.472MAPT, PSEN1
regulation of cellular component organization (GO:0051128) 2.012MAPT, PSEN1
positive regulation of developmental process (GO:0051094) 2.772MAPT, PSEN1
neuron migration (GO:0001764) 5.02MAPT, PSEN1
signal transduction (GO:0007165) 1.282MAPT, PSEN1
cellular component organization (GO:0016043) 1.242MAPT, PSEN1
cellular component organization or biogenesis (GO:0071840) 1.222MAPT, PSEN1
intracellular signal transduction (GO:0035556) 2.392MAPT, PSEN1
positive regulation of neurogenesis (GO:0050769) 3.772MAPT, PSEN1
regulation of cell projection organization (GO:0031344) 3.382MAPT, PSEN1
cell death (GO:0008219) 3.052MAPT, PSEN1
positive regulation of cell projection organization (GO:0031346) 3.992MAPT, PSEN1
regulation of neurogenesis (GO:0050767) 3.212MAPT, PSEN1
anatomical structure morphogenesis (GO:0009653) 2.532MAPT, PSEN1
cellular developmental process (GO:0048869) 1.822MAPT, PSEN1
positive regulation of multicellular organismal process (GO:0051240) 2.492MAPT, PSEN1
movement of cell or subcellular component (GO:0006928) 2.612MAPT, PSEN1
regulation of cell development (GO:0060284) 3.012MAPT, PSEN1
regulation of biological process (GO:0050789) 0.452MAPT, PSEN1
regulation of neuron differentiation (GO:0045664) 3.392MAPT, PSEN1
positive regulation of neuron differentiation (GO:0045666) 3.982MAPT, PSEN1
biological regulation (GO:0065007) 0.392MAPT, PSEN1
single-organism process (GO:0044699) 0.482MAPT, PSEN1
positive regulation of cell development (GO:0010720) 3.572MAPT, PSEN1
positive regulation of biological process (GO:0048518) 1.22MAPT, PSEN1
negative regulation of biological process (GO:0048519) 1.332MAPT, PSEN1
cell migration (GO:0016477) 3.122MAPT, PSEN1
positive regulation of cellular component organization (GO:0051130) 2.682MAPT, PSEN1
organelle organization (GO:0006996) 2.022MAPT, PSEN1
multicellular organismal process (GO:0032501) 1.452MAPT, PSEN1
regulation of developmental process (GO:0050793) 2.12MAPT, PSEN1
transport (GO:0006810) 1.512MAPT, PSEN1
regulation of cellular process (GO:0050794) 0.52MAPT, PSEN1
single-organism developmental process (GO:0044767) 1.492MAPT, PSEN1
programmed cell death (GO:0012501) 3.12MAPT, PSEN1
regulation of cell differentiation (GO:0045595) 2.422MAPT, PSEN1
single-organism cellular process (GO:0044763) 0.652MAPT, PSEN1
positive regulation of neuron projection development (GO:0010976) 4.262MAPT, PSEN1
regulation of multicellular organismal process (GO:0051239) 1.872MAPT, PSEN1
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912MAPT, PSEN1
neurogenesis (GO:0022008) 5.452MAPT, PSEN1
establishment of localization (GO:0051234) 1.482MAPT, PSEN1
localization (GO:0051179) 1.42MAPT, PSEN1
brain development (GO:0007420) 4.242MAPT, PSEN1
locomotion (GO:0040011) 2.912MAPT, PSEN1
animal organ development (GO:0048513) 2.532MAPT, PSEN1
regulation of axonogenesis (GO:0050770) 4.592MAPT, PSEN1
single-multicellular organism process (GO:0044707) 1.782MAPT, PSEN1
cell motility (GO:0048870) 3.022MAPT, PSEN1
single-organism behavior (GO:0044708) 3.792MAPT, PSEN1
response to stimulus (GO:0050896) 1.222MAPT, PSEN1
anatomical structure development (GO:0048856) 1.582MAPT, PSEN1
positive regulation of cell differentiation (GO:0045597) 3.012MAPT, PSEN1
positive regulation of nervous system development (GO:0051962) 3.642MAPT, PSEN1
regulation of nervous system development (GO:0051960) 3.12MAPT, PSEN1
regulation of multicellular organismal development (GO:2000026) 2.312MAPT, PSEN1
cellular process (GO:0009987) 0.262MAPT, PSEN1
apoptotic process (GO:0006915) 3.142MAPT, PSEN1
positive regulation of cellular process (GO:0048522) 1.32MAPT, PSEN1

NET-GE enrichment

Term New enriched termICP valueGenes
dicarboxylic acid transport (GO:0006835) NEW5.620.025MAPT, PSEN1
neuron migration (GO:0001764) -5.00.019MAPT, PSEN1
regulation of axonogenesis (GO:0050770) -4.590.018MAPT, PSEN1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
site of polarized growth (GO:0030427) 4.852MAPT, PSEN1
growth cone (GO:0030426) 4.892MAPT, PSEN1
dendrite (GO:0030425) 3.922MAPT, PSEN1
axon (GO:0030424) 4.152MAPT, PSEN1
intracellular organelle (GO:0043229) 0.512MAPT, PSEN1
non-membrane-bounded organelle (GO:0043228) 1.762MAPT, PSEN1
membrane-bounded organelle (GO:0043227) 0.472MAPT, PSEN1
organelle (GO:0043226) 0.42MAPT, PSEN1
nucleus (GO:0005634) 1.072MAPT, PSEN1
membrane (GO:0016020) 0.682MAPT, PSEN1
neuron part (GO:0097458) 2.642MAPT, PSEN1
cytoskeletal part (GO:0044430) 2.492MAPT, PSEN1
neuron projection (GO:0043005) 3.122MAPT, PSEN1
synapse part (GO:0044456) 3.422MAPT, PSEN1
cell body (GO:0044297) 3.742MAPT, PSEN1
inclusion body (GO:0016234) 5.552MAPT, PSEN1
plasma membrane (GO:0005886) 1.392MAPT, PSEN1
cell projection (GO:0042995) 2.472MAPT, PSEN1
protein complex (GO:0043234) 1.512MAPT, PSEN1
macromolecular complex (GO:0032991) 1.352MAPT, PSEN1
intracellular membrane-bounded organelle (GO:0043231) 0.62MAPT, PSEN1
intracellular non-membrane-bounded organelle (GO:0043232) 1.762MAPT, PSEN1
cell projection part (GO:0044463) 2.972MAPT, PSEN1
cell part (GO:0044464) 0.112MAPT, PSEN1
intracellular organelle part (GO:0044446) 0.812MAPT, PSEN1
cytoplasmic part (GO:0044444) 0.822MAPT, PSEN1
nuclear part (GO:0044428) 1.552MAPT, PSEN1
ciliary part (GO:0044441) 4.052MAPT, PSEN1
intracellular part (GO:0044424) 0.282MAPT, PSEN1
organelle part (GO:0044422) 0.792MAPT, PSEN1

NET-GE enrichment

Term New enriched termICP valueGenes
trans-Golgi network (GO:0005802) NEW4.920.029MAPT, PSEN1
late endosome (GO:0005770) NEW4.850.044MAPT, PSEN1
site of polarized growth (GO:0030427) -4.850.048MAPT, PSEN1
growth cone (GO:0030426) -4.890.045MAPT, PSEN1
axon (GO:0030424) -4.150.007MAPT, PSEN1
ciliary part (GO:0044441) -4.050.013MAPT, PSEN1