Disease table of DILATED CARDIOMYOPATHY OMIM ID: PS115200

Gene-disease associations table

Gene	Associated with DILATED CARDIOMYOPATHY in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
BAG3	ClinVar, OMIM, HUMSAVAR	HGNC link	10q26.11	2	PS115200, PS601419
TMPO	ClinVar, OMIM, HUMSAVAR	HGNC link	12q23.1	1	PS115200
DMD	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp21.1	3	300376, PS115200, 310200
ACTC1	ClinVar, OMIM, HUMSAVAR	HGNC link	15q14	4	PS108800, PS192600, PS115200, PS604169
DES	ClinVar, OMIM, HUMSAVAR	HGNC link	2q35	5	181400, PS253600, PS601419, 142340, PS115200
CRYAB	ClinVar, OMIM, HUMSAVAR	HGNC link	11q23.1	3	PS116200, PS115200, PS601419
TNNC1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.1	2	PS192600, PS115200
FKTN	ClinVar, OMIM, HUMSAVAR	HGNC link	9q31.2	4	PS236670, PS613155, PS115200, PS253600
RAF1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p25.2	3	PS163950, PS115200, PS151100
TNNT2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q32.1	5	PS192600, PS604169, 218040, PS115200, PS115210
MYH6	ClinVar, OMIM, HUMSAVAR	HGNC link	14q11.2	6	PS192600, 234750, PS108800, PS115200, 140500, PS608567
MYH7	ClinVar, OMIM, HUMSAVAR	HGNC link	14q11.2	9	PS192600, 160500, PS604169, PS115200, 603829, 255310, 255160, 608358, 181430
PSEN2	ClinVar, OMIM	HGNC link	1q42.13	3	606889, PS115200, 104300
PSEN1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q24.2	7	607822, 172700, 600274, 104300, PS142690, 606889, PS115200
SGCD	ClinVar, OMIM, HUMSAVAR	HGNC link	5q33.2	2	PS115200, PS253600
TPM1	ClinVar, OMIM, HUMSAVAR	HGNC link	15q22.2	4	PS604169, PS604772, PS115200, PS192600
MYPN	ClinVar, OMIM, HUMSAVAR	HGNC link	10q21.3	3	PS192600, PS115200, PS115210
TNNI3	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.42	3	PS192600, PS115200, PS115210
DSG2	ClinVar, OMIM	HGNC link	18q12.1	4	115000, PS604772, PS115200, PS107970
EYA4	ClinVar, OMIM	HGNC link	6q23.2	2	PS115200, PS124900
NEXN	ClinVar, OMIM, HUMSAVAR	HGNC link	1p31.1	2	PS192600, PS115200
TTN	ClinVar, OMIM, HUMSAVAR	HGNC link	2q31.2	8	PS192600, PS253600, 600334, PS115200, 603689, 603829, 611705, PS160150
LAMA4	ClinVar, OMIM, HUMSAVAR	HGNC link	6q21	2	PS115200, PS604772
VCL	ClinVar, OMIM, HUMSAVAR	HGNC link	10q22.2	3	PS192600, PS115200, 603829
LDB3	ClinVar, OMIM, HUMSAVAR	HGNC link	10q23.2	4	PS604169, PS192600, PS601419, PS115200
LMNA	ClinVar, OMIM, HUMSAVAR	HGNC link	1q22	12	212112, PS310300, PS248370, PS176670, PS118220, PS604772, PS159000, PS115200, 613205, 275210, 610140, PS151660
CSRP3	ClinVar, OMIM, HUMSAVAR	HGNC link	11p15.1	2	PS192600, PS115200
PRDM16	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.32	2	PS604169, PS115200
ACTN2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q43	2	PS192600, PS115200
MYBPC3	ClinVar, OMIM, HUMSAVAR	HGNC link	11p11.2	4	PS604169, PS604772, PS115200, PS192600
ABCC9	ClinVar, OMIM, HUMSAVAR	HGNC link	12p12.1	3	PS115200, 239850, PS608583
RBM20	ClinVar, OMIM, HUMSAVAR	HGNC link	10q25.2	2	PS115200, 603829
SDHA	ClinVar, OMIM, HUMSAVAR	HGNC link	5p15.33	5	252011, 604287, PS115200, PS168000, 256000
PLN	ClinVar, OMIM, HUMSAVAR	HGNC link	6q22.31	2	PS192600, PS115200
GATAD1	ClinVar, OMIM, HUMSAVAR	HGNC link	7q21.2	1	PS115200
SCN5A	ClinVar, OMIM, HUMSAVAR	HGNC link	3p22.2	11	272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 626	2	MYH6, MYH7

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
14q11.2	2	MYH6, MYH7

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
14q11	2	MYH6, MYH7

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
6q2	3	LAMA4, EYA4, PLN
3p2	3	RAF1, SCN5A, TNNC1
1p3	2	NEXN, PRDM16
11p1	2	CSRP3, MYBPC3
14q1	2	MYH6, MYH7
2q3	2	DES, TTN
1q4	2	ACTN2, PSEN2
10q2	5	BAG3, MYPN, LDB3, VCL, RBM20

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
15q	2	ACTC1, TPM1
1q	4	LMNA, TNNT2, ACTN2, PSEN2
2q	2	DES, TTN
14q	3	MYH6, MYH7, PSEN1
3p	3	RAF1, SCN5A, TNNC1
6q	3	LAMA4, EYA4, PLN
11p	2	CSRP3, MYBPC3
10q	5	BAG3, MYPN, LDB3, VCL, RBM20
1p	2	NEXN, PRDM16

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	CRYAB, CSRP3, MYBPC3
10	5	BAG3, MYPN, LDB3, VCL, RBM20
12	2	TMPO, ABCC9
15	2	ACTC1, TPM1
14	3	MYH6, MYH7, PSEN1
1	6	PRDM16, NEXN, ACTN2, LMNA, TNNT2, PSEN2
3	3	RAF1, SCN5A, TNNC1
2	2	DES, TTN
5	2	SDHA, SGCD
6	3	LAMA4, EYA4, PLN

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	3	TNNI3, PSEN1, TMPO
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	2	PSEN2, TMPO

regulated gene	associated to this disease	# TFs	TFs
BAG3	YES	2	GTF3A, HSF1
TMPO	YES	2	SP1, EGR1
DMD	YES	1	SRF
ACTC1	YES	1	YY1
DES	YES	1	TRIM16
CRYAB	YES	4	TP53, HMGA1, TFAP2B, TFAP2A
MYH6	YES	3	JARID2, TBX5, ELK3
PSEN2	YES	1	EGR1
PSEN1	YES	3	SP1, CREB1, ELK1
TNNI3	YES	2	SP1, MEF2A

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
BAG3	TMPO	No	3	SRPK2, CLK1, YWHAE
BAG3	DMD	No	3	TERF2, TERF1, PTRF
BAG3	ACTC1	No	2	PDCD6IP, CAPN1
BAG3	DES	No	7	CRYAB, CAPN1, CCT7, HNRNPUL1, S100A1, HSPB1, YWHAQ
BAG3	CRYAB	Yes	10	CRYAB, BCL2, HSPA4, BAX, CASP3, PRKAG3, HSPB1, HSPB8, PSMA3, BAG3
BAG3	TNNC1	No	2	CDK1, UBE2C
BAG3	RAF1	No	18	HSP90AA1, BAG1, HSPA8, BCL2, MAPK7, YWHAH, HSPA4, PPP2CA, PEBP1, VDAC1, YWHAE, YWHAG, YWHAZ, NXF1, STUB1, YWHAQ, YWHAB, SYNPO
BAG3	MYH6	No	1	COPE
BAG3	MYH7	No	3	KEAP1, PDCD6, YWHAQ
BAG3	PSEN2	No	2	CLK1, CAPN1
BAG3	PSEN1	No	6	BCL2, IRAK2, PSMA5, ETFA, PSMB1, ST13
BAG3	TPM1	No	7	IKBKG, PDLIM7, SF3B2, ETFA, SYNPO, YWHAQ, STUB1
BAG3	MYPN	No	1	DHX8
BAG3	TNNI3	No	1	PSMC5
BAG3	DSG2	No	1	SYNPO
BAG3	NEXN	No	3	MAPRE1, HSPB1, SYNPO
BAG3	TTN	No	6	CRYAB, SRPK2, CUL4B, EWSR1, YWHAQ, SQSTM1
BAG3	VCL	No	12	GNAI3, SORBS2, G6PD, YWHAE, YWHAH, PSME1, CAPZB, YWHAG, EWSR1, YWHAQ, SEC16A, YWHAZ
BAG3	LDB3	No	1	HSPA1A
BAG3	LMNA	No	21	CLK1, RANBP2, SRPK2, ISG15, SENP1, CRK, IRAK1, PDLIM3, GPKOW, URB2, MCM5, SLC25A6, YKT6, NCL, SLC25A5, PARP1, NXF1, YWHAQ, DYNLT1, CRKL, PRKDC
BAG3	PRDM16	No	1	SMAD3
BAG3	ACTN2	No	7	CAPN1, PSMB5, PSMA3, PDLIM3, HSPB1, SYNPO2, YWHAQ
BAG3	MYBPC3	No	1	CAPN1
BAG3	SDHA	No	5	NXF1, HSPB1, CPNE1, ACLY, SQSTM1
BAG3	GATAD1	No	1	NXF1
TMPO	DMD	No	1	ARRB1
TMPO	ACTC1	No	3	ARRB2, MYC, CCDC8
TMPO	RAF1	No	8	PHB, ARRB2, YWHAE, RB1, TMEM63B, OIP5, FYCO1, MYC
TMPO	MYH6	No	1	BRD1
TMPO	PSEN2	No	1	CLK1
TMPO	PSEN1	No	1	UNK
TMPO	DSG2	No	8	TMEM216, OBSL1, EED, ABCE1, CCDC8, GAG, CBX1, CUL7
TMPO	TTN	No	4	NTRK1, ARRB1, SRPK2, CUL7
TMPO	LAMA4	No	1	LGALS3
TMPO	VCL	No	3	UNK, NTRK1, YWHAE
TMPO	LMNA	Yes	27	CDC5L, LMNB2, OBSL1, SCARNA22, SNW1, LMNB1, PHB, HIST1H3E, PCGF2, ABCE1, RPA1, LMNA, BANF1, NUP133, SRPK2, FBXO6, EED, MRE11A, HP1BP3, CLK1, USP7, CCDC8, RB1, NTRK1, MYC, FYCO1, CUL7
TMPO	ACTN2	No	2	SNW1, RPL35
TMPO	SDHA	No	4	NTRK1, ARRB2, CRY2, FBXO6
DMD	ACTC1	No	2	MCM2, TRAF3IP1
DMD	CRYAB	No	2	ALB, APP
DMD	RAF1	No	4	CDC25A, MAP3K5, NEDD4, XPO1
DMD	TNNT2	No	1	APP
DMD	MYH6	No	1	MCM2
DMD	MYH7	No	1	DISC1
DMD	PSEN2	No	1	APP
DMD	PSEN1	No	3	DTNA, CTNNA1, APP
DMD	MYPN	No	2	MCM2, XPO1
DMD	TTN	No	4	GAN, ALB, ARRB1, MCM2
DMD	VCL	No	3	DAG1, CTNNA1, XPO1
DMD	LDB3	No	1	ALB
DMD	LMNA	No	1	MCM2
DMD	ACTN2	No	1	DISC1
DMD	SCN5A	No	6	SNTB1, GAN, ALB, SNTA1, SNTB2, NEDD4
ACTC1	DES	No	2	SP1, CAPN1
ACTC1	CRYAB	No	2	HSPB2, ACTA2
ACTC1	RAF1	No	3	SH3KBP1, MYC, ARRB2
ACTC1	TNNT2	No	1	TPM1
ACTC1	MYH6	No	3	MCM2, TPM1, HSPB2
ACTC1	PSEN2	No	1	CAPN1
ACTC1	PSEN1	No	1	GAPDH
ACTC1	TPM1	Yes	4	SP1, TPM1, PAN2, ACTA2
ACTC1	MYPN	No	1	MCM2
ACTC1	TNNI3	No	2	TNNI3K, HSPB2
ACTC1	DSG2	No	2	CCDC8, PAN2
ACTC1	NEXN	No	1	PAN2
ACTC1	TTN	No	3	SP1, MCM2, HSPB2
ACTC1	LAMA4	No	1	GAPDH
ACTC1	VCL	No	1	ITGA4
ACTC1	LMNA	No	6	MCM2, CD2AP, CCDC8, MYC, UCHL5, ITGA4
ACTC1	ACTN2	No	2	CAPN1, TPM1
ACTC1	MYBPC3	No	3	CAPN1, TNNI3K, HSPB2
ACTC1	ABCC9	No	1	HSPB2
ACTC1	SDHA	No	4	ARRB2, ITGA4, SYNE2, HSPB2
DES	CRYAB	Yes	2	CRYAB, HSPB1
DES	TNNC1	No	1	TRIM63
DES	RAF1	No	2	YWHAQ, MOV10
DES	MYH7	No	2	YWHAQ, SPTAN1
DES	PSEN2	No	1	CAPN1
DES	PSEN1	No	1	DSP
DES	TPM1	No	4	SP1, BRCA1, YWHAQ, NEB
DES	MYPN	No	1	NEB
DES	TNNI3	No	2	TRIM55, TRIM63
DES	DSG2	No	1	JUP
DES	NEXN	No	1	HSPB1
DES	TTN	No	5	SP1, TRIM55, YWHAQ, CRYAB, TRIM63
DES	VCL	No	2	YWHAQ, SPTAN1
DES	LMNA	No	3	UBE2I, YWHAQ, MOV10
DES	ACTN2	No	3	HSPB1, CAPN1, YWHAQ
DES	MYBPC3	No	3	TRIM55, CAPN1, TRIM63
DES	SDHA	No	1	HSPB1
DES	GATAD1	No	1	MOV10
CRYAB	RAF1	No	4	BCL2L1, HSPA4, XIAP, BCL2
CRYAB	TNNT2	No	1	APP
CRYAB	MYH6	No	1	HSPB2
CRYAB	MYH7	No	1	PSMD4
CRYAB	PSEN2	No	3	BCL2L1, GFAP, APP
CRYAB	PSEN1	No	6	BCL2L1, BCL2, CDH1, GFAP, CTNNB1, APP
CRYAB	TPM1	No	3	TP53, ACTA2, SORD
CRYAB	MYPN	No	1	TTN
CRYAB	TNNI3	No	1	HSPB2
CRYAB	NEXN	No	1	HSPB1
CRYAB	TTN	Yes	3	CRYAB, ALB, HSPB2
CRYAB	LAMA4	No	1	TP53
CRYAB	VCL	No	2	CTNNB1, CDH1
CRYAB	LDB3	No	1	ALB
CRYAB	LMNA	No	3	TP53, CTNNB1, CDH1
CRYAB	ACTN2	No	2	HSPB1, PSMA3
CRYAB	MYBPC3	No	2	TTN, HSPB2
CRYAB	ABCC9	No	1	HSPB2
CRYAB	SDHA	No	4	HSPB1, HSPB2, CS, MDH2
CRYAB	GATAD1	No	1	HDAC1
CRYAB	SCN5A	No	1	ALB
TNNC1	TNNT2	Yes	2	TNNI3, TNNI1
TNNC1	MYH6	No	1	TNNI1
TNNC1	MYH7	No	1	TNNI1
TNNC1	TPM1	No	5	TNNI1, TNNT3, TNNT2, CNN1, TNNT1
TNNC1	TNNI3	Yes	2	TNNT2, TRIM63
TNNC1	TTN	No	1	TRIM63
TNNC1	VCL	No	1	HSPB2
TNNC1	ACTN2	No	1	TNNI1
TNNC1	MYBPC3	No	1	TRIM63
RAF1	MYH7	No	1	YWHAQ
RAF1	PSEN2	No	2	BCL2L1, RHEB
RAF1	PSEN1	No	4	BCL2L1, CDC37, RHEB, BCL2
RAF1	TPM1	No	5	CDC37, SYNPO, YWHAQ, EGFR, STUB1
RAF1	MYPN	No	1	XPO1
RAF1	DSG2	No	2	SYNPO, EGFR
RAF1	NEXN	No	2	CALM1, SYNPO
RAF1	TTN	No	4	CALM1, COPS5, MAPK1, YWHAQ
RAF1	LAMA4	No	1	EEF1A1
RAF1	VCL	No	9	VCP, YWHAH, YWHAE, XPO1, YWHAG, SFN, HSPA5, YWHAQ, YWHAZ
RAF1	LMNA	No	14	PHB, RFXANK, PPP1CC, VCP, EMD, FYCO1, HERC2, NPLOC4, ILK, RB1, NXF1, YWHAQ, MYC, MOV10
RAF1	ACTN2	No	1	YWHAQ
RAF1	SDHA	No	4	TIMM50, COPS5, ARRB2, NXF1
RAF1	GATAD1	No	2	NXF1, MOV10
RAF1	SCN5A	No	2	CALM1, NEDD4
TNNT2	MYH6	No	2	TPM1, TNNI1
TNNT2	MYH7	No	1	TNNI1
TNNT2	PSEN2	No	1	APP
TNNT2	PSEN1	No	1	APP
TNNT2	TPM1	Yes	2	TPM1, TNNI1
TNNT2	TNNI3	Yes	1	TNNC1
TNNT2	LMNA	No	1	MORF4L2
TNNT2	ACTN2	No	2	TPM1, TNNI1
TNNT2	GATAD1	No	1	MORF4L2
MYH6	MYH7	No	3	ACTN2, TNNI1, TPM2
MYH6	PSEN1	No	1	UMPS
MYH6	TPM1	Yes	4	ACTN2, TPM1, TNNI1, TPM2
MYH6	MYPN	No	2	ACTN2, MCM2
MYH6	TNNI3	No	1	HSPB2
MYH6	TTN	No	2	MCM2, HSPB2
MYH6	LDB3	No	1	ACTN2
MYH6	LMNA	No	2	MCM2, MCM3AP
MYH6	ACTN2	Yes	4	ACTN2, TPM1, TNNI1, TPM2
MYH6	MYBPC3	No	1	HSPB2
MYH6	ABCC9	No	1	HSPB2
MYH6	SDHA	No	1	HSPB2
MYH7	TPM1	No	6	ACTN2, TNNI1, KXD1, RBPJ, YWHAQ, TPM2
MYH7	MYPN	No	2	ACTN2, ACTN3
MYH7	EYA4	No	1	SIX1
MYH7	TTN	No	1	YWHAQ
MYH7	VCL	No	2	YWHAQ, SPTAN1
MYH7	LDB3	No	1	ACTN2
MYH7	LMNA	No	3	SIRT6, WWOX, YWHAQ
MYH7	ACTN2	Yes	6	ACTN2, DISC1, TNNI1, ACTN3, YWHAQ, TPM2
PSEN2	PSEN1	Yes	23	BCL2L1, FBXL12, PDCD4, KCNIP4, RNF32, APP, GCDH, KCNIP3, UBQLN1, RHEB, FLNB, APH1B, ECSIT, APH1A, NCSTN, NOS3, TRAF6, GFAP, PSEN1, ICAM5, PSENEN, PSEN2, CIB1
PSEN2	TPM1	No	2	MGEA5, ELAVL1
PSEN2	TTN	No	1	FHL2
PSEN2	VCL	No	2	PPP5C, ACTG1
PSEN2	LMNA	No	1	CLK1
PSEN2	ACTN2	No	2	NOS3, CAPN1
PSEN2	MYBPC3	No	1	CAPN1
PSEN1	TPM1	No	5	UBC, TGFBR1, CDC37, ACTN1, ETFA
PSEN1	TTN	No	1	ACTN1
PSEN1	LAMA4	No	1	GAPDH
PSEN1	VCL	No	4	UNK, CTNNA1, CTNNB1, CDH1
PSEN1	LMNA	No	2	CTNNB1, CDH1
PSEN1	ACTN2	No	2	NOS3, ACTN1
PSEN1	SDHA	No	3	UBC, NDUFS8, OXCT1
TPM1	MYPN	No	3	ACTN2, NEB, CAPZA2
TPM1	TNNI3	No	1	TNNT2
TPM1	DSG2	No	13	IQGAP1, EGFR, CORO1C, ACTB, FLNA, MYO18A, MYO19, MYH9, PAN2, TMOD3, MYH10, SYNPO, DBN1
TPM1	NEXN	No	18	MYO1C, CORO1C, CALML3, ACTB, ANLN, IQGAP1, MYH9, PPP1CB, MYO19, CAPZA2, SYNPO, TMOD3, MYO18A, MYH10, LIMA1, FLNA, PAN2, DBN1
TPM1	TTN	No	4	SP1, YWHAQ, ACTN1, CDK2
TPM1	LAMA4	No	1	TP53
TPM1	VCL	No	3	YWHAQ, CDK2, ABI2
TPM1	LDB3	No	2	ACTN2, ATP5F1
TPM1	LMNA	No	7	CDK2, ANLN, PARK2, MDC1, TP53, YWHAQ, FLNA
TPM1	ACTN2	Yes	14	ACTN2, TPM1, MYH2, ACTN1, YWHAQ, MYH4, TNNI1, MYH6, MYH1, TPM3, TPM4, ACTN4, MYH8, TPM2
TPM1	SDHA	No	2	UBC, ATP5F1
TPM1	SCN5A	No	1	CDK2
MYPN	NEXN	No	1	CAPZA2
MYPN	TTN	Yes	4	ANKRD1, MCM2, DLG4, ANKRD23
MYPN	VCL	No	1	XPO1
MYPN	LDB3	No	1	ACTN2
MYPN	LMNA	No	1	MCM2
MYPN	ACTN2	Yes	2	ACTN2, ACTN3
MYPN	MYBPC3	No	1	TTN
MYPN	GATAD1	No	1	MTA2
TNNI3	TTN	No	3	TRIM55, HSPB2, TRIM63
TNNI3	MYBPC3	No	4	TRIM55, HSPB2, TRIM63, TNNI3K
TNNI3	ABCC9	No	1	HSPB2
TNNI3	SDHA	No	1	HSPB2
DSG2	NEXN	No	19	TPM1, FLOT1, CORO1C, MYO19, ACTB, TRIM69, IQGAP1, FLNB, MYO18A, MYH9, PAN2, TMOD3, MYO5C, MYH10, FLNA, LIMA1, FLOT2, SYNPO, DBN1
DSG2	TTN	No	2	ADRB2, CUL7
DSG2	VCL	No	1	LIMA1
DSG2	LMNA	No	6	OBSL1, EED, FLNA, ABCE1, CCDC8, CUL7
NEXN	TTN	No	1	CALM1
NEXN	VCL	No	3	MYO1C, LIMA1, TRIM15
NEXN	LMNA	No	2	FLNA, ANLN
NEXN	ACTN2	No	1	HSPB1
NEXN	MYBPC3	No	1	CUL1
NEXN	SDHA	No	2	CUL1, HSPB1
NEXN	SCN5A	No	1	CALM1
TTN	VCL	No	4	NTRK1, EWSR1, YWHAQ, CDK2
TTN	LDB3	No	1	ALB
TTN	LMNA	No	9	SRPK2, CDK2, CPSF6, MCM2, RAPGEF2, FHL1, NTRK1, YWHAQ, CUL7
TTN	ACTN2	No	3	YWHAQ, MYPN, ACTN1
TTN	MYBPC3	Yes	3	TRIM55, HSPB2, TRIM63
TTN	ABCC9	No	1	HSPB2
TTN	SDHA	No	7	NEDD8, HSPB2, COPS5, CUL3, NTRK1, CUL2, SQSTM1
TTN	SCN5A	No	4	GAN, ALB, CALM1, CDK2
LAMA4	VCL	No	1	UBR1
LAMA4	LMNA	No	1	TP53
LAMA4	SDHA	No	1	COPS6
VCL	LMNA	No	12	FN1, CDK2, VCP, SIRT7, VCAM1, EIF5, SVIL, CDH1, CTNNB1, NTRK1, YWHAQ, ITGA4
VCL	ACTN2	No	1	YWHAQ
VCL	SDHA	No	7	HSPA9, PDHA1, SDHAF2, FN1, SIRT7, NTRK1, ITGA4
VCL	SCN5A	No	1	CDK2
LDB3	ACTN2	Yes	1	ACTN2
LDB3	SDHA	No	1	ATP5F1
LDB3	SCN5A	No	1	ALB
LMNA	ACTN2	No	3	SNW1, YWHAQ, PDLIM3
LMNA	SDHA	No	7	FN1, XRCC6, SIRT7, FBXO6, NTRK1, NXF1, ITGA4
LMNA	GATAD1	No	6	MORF4L1, SHMT2, MORF4L2, MOV10, NXF1, ENO1
LMNA	SCN5A	No	1	CDK2
PRDM16	GATAD1	No	1	HDAC2
ACTN2	MYBPC3	No	1	CAPN1
ACTN2	SDHA	No	1	HSPB1
MYBPC3	ABCC9	No	1	HSPB2
MYBPC3	SDHA	No	2	CUL1, HSPB2
ABCC9	SDHA	No	1	HSPB2
SDHA	GATAD1	No	1	NXF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
BAG3	TMPO	No	-	1	UBC
BAG3	ACTC1	No	-	1	UBC
BAG3	DES	No	-	1	UBC
BAG3	TNNC1	No	-	1	UBC
BAG3	RAF1	No	-	6	HSPA8, BCL2, HSPA4, HSP90AA1, HSP90AB1, UBC
BAG3	MYH6	No	-	4	UBC, PTPN23, HSP90AA1, HSP90AB1
BAG3	MYH7	No	-	2	HSP90AA1, HSP90AB1
BAG3	PSEN2	No	-	1	UBC
BAG3	PSEN1	No	-	3	UBC, BCL2, CDH1
BAG3	TPM1	No	-	1	UBC
BAG3	DSG2	No	-	1	UBC
BAG3	TTN	No	-	1	UBC
BAG3	VCL	No	-	3	UBC, HSP90AA1, CDH1
BAG3	ACTN2	No	-	1	UBC
BAG3	SDHA	No	-	1	UBC
TMPO	ACTC1	No	-	1	UBC
TMPO	DES	No	-	1	UBC
TMPO	TNNC1	No	-	1	UBC
TMPO	RAF1	No	-	1	UBC
TMPO	MYH6	No	-	1	UBC
TMPO	PSEN2	No	-	1	UBC
TMPO	PSEN1	No	-	1	UBC
TMPO	TPM1	No	-	1	UBC
TMPO	DSG2	No	-	1	UBC
TMPO	TTN	No	-	1	UBC
TMPO	VCL	No	-	1	UBC
TMPO	ACTN2	No	-	1	UBC
TMPO	SDHA	No	-	1	UBC
ACTC1	DES	No	-	14	TPM1, MYH3, MYL2, TNNC1, MYH8, TPM3, TNNI3, TNNC2, MYH6, UBC, TPM4, MYL4, TPM2, MYL3
ACTC1	TNNC1	Yes	activation	17	TPM1, MYO5B, MYL3, MYH7, MYH8, TPM3, TNNI3, MYH14, TNNC2, MYH3, MYH6, UBC, MYL2, TPM4, MYL4, TPM2, MYO5C
ACTC1	RAF1	No	-	1	UBC
ACTC1	TNNT2	No	-	15	TPM1, MYH6, MYH7, TNNC1, MYH8, TPM3, TNNI3, MYH14, TNNC2, MYH3, MYL2, TPM4, MYL4, TPM2, MYL3
ACTC1	MYH6	Yes	binding	21	TPM4, TPM1, MYH11, MYH7, MYH2, TNNC1, MYL4, TPM2, TPM3, MYH14, MYH3, TNNI3, MYH9, TNNC2, MYH8, MYH1, UBC, MYH10, MYH4, MYL2, MYL3
ACTC1	MYH7	Yes	binding	18	TPM1, MYH11, MYL3, MYL2, TPM2, MYH4, MYH2, MYH14, MYH3, TNNI3, TNNC1, MYH1, TNNC2, TPM3, MYH6, MYH10, MYH8, MYH9
ACTC1	PSEN2	No	-	1	UBC
ACTC1	PSEN1	No	-	1	UBC
ACTC1	TPM1	Yes	binding	20	TPM2, CFL1, MYH11, MYH6, MYH7, TNNC1, MYL4, TPM3, MYH1, MYH3, TNNI3, MYH14, MYL2, UBC, DSTN, TPM4, ACTN4, MYH8, TNNC2, MYL3
ACTC1	TNNI3	Yes	binding	18	MYL3, TPM1, MYH11, MYH6, MYH7, MYL2, MYH8, MYH14, MYH3, TNNC1, MYH1, TNNC2, TPM3, MYO5B, TPM4, MYL4, TPM2, MYO5C
ACTC1	DSG2	No	-	1	UBC
ACTC1	TTN	No	-	16	TPM1, MYL3, MYL2, TNNC1, MYH8, MYH3, TNNI3, MYH14, MYL4, TNNC2, TPM3, MYH6, UBC, TPM4, WDR1, TPM2
ACTC1	VCL	No	-	14	TPM1, MYH11, PFN1, WDR1, CORO2B, SRF, PFN2, TPM3, PFN4, UBC, TPM4, ACTN4, WASL, TPM2
ACTC1	LDB3	No	-	1	ACTN4
ACTC1	ACTN2	No	-	16	TPM1, MYH6, MYH7, TNNC1, MYH8, MYH3, TNNI3, TNNC2, TPM3, UBC, MYL2, TPM4, ACTN4, MYL4, TPM2, MYL3
ACTC1	MYBPC3	No	-	21	TPM4, TPM1, MYH11, MYH6, MYH2, TNNC1, MYL4, TPM2, TPM3, MYH14, MYH3, TNNI3, MYH9, TNNC2, MYH8, MYH1, MYH7, MYH10, MYH4, MYL2, MYL3
ACTC1	SDHA	No	-	1	UBC
ACTC1	PLN	No	-	0
DES	TNNC1	Yes	binding	27	TPM1, TMOD1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNI2, UBC, TPM4
DES	RAF1	No	-	1	UBC
DES	TNNT2	Yes	binding	26	TPM1, TMOD1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, MYL3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TTN, TNNI2, TPM4
DES	MYH6	Yes	binding	27	TPM1, TMOD1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYL3, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TTN, TNNI2, UBC, TPM4
DES	MYH7	No	-	18	ACTN2, TNNI3, TPM1, TNNT2, TPM3, MYL2, TNNC1, MYH8, TNNI1, MYL1, MYH6, TNNI2, TNNT3, TNNC2, MYH3, MYBPC3, TPM2, MYL3
DES	PSEN2	No	-	1	UBC
DES	PSEN1	No	-	1	UBC
DES	TPM1	Yes	binding	27	TMOD1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, MYL3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TTN, TNNI2, UBC, TPM4
DES	MYPN	No	-	3	ACTN2, TTN, NEB
DES	TNNI3	Yes	binding	26	TPM1, TMOD1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, MYBPC3, MYL3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TTN, TNNI2, TPM4
DES	DSG2	No	-	1	UBC
DES	TTN	Yes	binding	27	TPM1, TMOD1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, MYL3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TNNI2, UBC, TPM4
DES	VCL	No	-	7	ACTN2, TPM1, TTN, TPM3, UBC, TPM4, TPM2
DES	LDB3	No	-	1	ACTN2
DES	ACTN2	Yes	binding	27	TPM1, TMOD1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, MYL3, MYL2, TNNC1, TNNI1, TPM3, TTN, TNNI2, UBC, TPM4
DES	MYBPC3	Yes	binding	26	TPM1, TMOD1, MYL4, TNNT3, VIM, MYH3, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC1, MYL3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TTN, TNNI2, TPM4
DES	SDHA	No	-	1	UBC
TNNC1	RAF1	No	-	1	UBC
TNNC1	TNNT2	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNI2, TPM4
TNNC1	MYH6	Yes	binding	30	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, ACTC1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNI2, UBC, TPM4
TNNC1	MYH7	Yes	binding	19	ACTN2, TNNI3, TPM1, TNNT2, MYL3, MYL2, TNNI1, MYH8, MYL1, ACTC1, MYH14, MYH3, TNNI2, TNNT3, TNNC2, TPM3, MYH6, MYBPC3, TPM2
TNNC1	PSEN2	No	-	1	UBC
TNNC1	PSEN1	No	-	1	UBC
TNNC1	TPM1	Yes	binding	30	TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNI2, UBC, TPM4
TNNC1	MYPN	No	-	3	ACTN2, TTN, NEB
TNNC1	TNNI3	Yes	binding	31	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, MYH7, MYO5B, MYBPC3, ACTN2, MYL2, TTN, MYO5C, DES, TPM3, TNNI2, TPM4
TNNC1	DSG2	No	-	1	UBC
TNNC1	TTN	Yes	binding	29	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, DES, TPM3, TNNI2, OBSCN, UBC, TPM4
TNNC1	VCL	No	-	7	ACTN2, TPM1, TTN, TPM3, UBC, TPM4, TPM2
TNNC1	LDB3	No	-	1	ACTN2
TNNC1	ACTN2	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, MYL2, TTN, TNNI1, TPM3, TNNI2, UBC, TPM4
TNNC1	MYBPC3	Yes	binding	28	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNI2, TPM4
TNNC1	SDHA	No	-	1	UBC
TNNC1	PLN	No	-	0
RAF1	MYH6	No	-	3	UBC, HSP90AA1, HSP90AB1
RAF1	MYH7	No	-	2	HSP90AA1, HSP90AB1
RAF1	PSEN2	No	-	3	UBC, BCL2L1, EGR1
RAF1	PSEN1	No	-	10	BCL2L1, BCL2, PRKX, ETS2, UBC, PRKACG, TP53, SRC, PRKACA, PRKACB
RAF1	TPM1	No	-	1	UBC
RAF1	TNNI3	No	-	9	PRKX, PPP2CA, PPP2R2B, PRKACG, PAK3, PPP2R1A, PPP2R2A, PRKACA, PRKACB
RAF1	DSG2	No	-	1	UBC
RAF1	TTN	No	-	1	UBC
RAF1	VCL	No	-	6	RHOA, HSP90AA1, UBC, PIK3CA, SRC, FYN
RAF1	LDB3	No	-	1	CCND1
RAF1	ACTN2	No	-	7	RAC1, HRAS, PIK3CA, UBC, IGF1, SRC, RHOA
RAF1	SDHA	No	-	1	UBC
RAF1	PLN	No	-	7	AKT1, PRKX, PRKACG, PRKG1, PRKACA, PRKG2, PRKACB
TNNT2	MYH6	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	MYH7	Yes	binding	18	ACTN2, MYL1, MYH6, MYL2, TNNC1, MYH8, TNNI1, MYH14, MYH3, TNNI3, TNNT3, TNNC2, TPM3, TPM1, MYBPC3, TNNI2, TPM2, MYL3
TNNT2	TPM1	Yes	binding	28	TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	MYPN	No	-	3	ACTN2, TTN, NEB
TNNT2	TNNI3	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	TTN	Yes	binding	28	TPM1, TMOD1, CD2AP, MYL4, TNNT3, VIM, TPM3, DES, TPM2, MYBPC1, MYL1, MYH6, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, MYL3, ACTN2, MYL2, TNNC1, TNNI1, MYH3, TNNI2, TPM4
TNNT2	VCL	No	-	6	ACTN2, TPM1, TTN, TPM3, TPM4, TPM2
TNNT2	LDB3	No	-	1	ACTN2
TNNT2	ACTN2	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	MYBPC3	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
MYH6	MYH7	Yes	binding	54	TPM1, HSP90AB1, RAB11A, TNNI1, MYH8, MYOM1, TNNT3, MYL3, MYL7, MYL12A, MYL6B, MYBPC3, MYL2, MYLPF, MYL1, MYH11, MYH2, KIF3C, ACTA1, MYH1, FCHO1, MYH14, TNNC2, ACTG2, EXOC6, TPM2, KIF3B, MYL5, RABL2A, TPM3, ACTA2, MYH4, ACTC1, RAB11B, HSP90AA1, TNNI3, MYL9, CGN, TNNT2, MYL12B, GAS7, FCHO2, KIF5B, ACTN2, ACTBL2, EXOC6B, RAB25, MYH13, MYH9, MYH3, TNNC1, TNNI2, MYH10, KIF5A
MYH6	PSEN2	No	-	1	UBC
MYH6	PSEN1	No	-	2	MYOD1, UBC
MYH6	TPM1	Yes	binding	38	TMOD1, TNNI1, MYH8, TNNT3, VIM, MYL3, MYH1, MYL6B, MYBPC3, TNNC2, MYBPC1, TNNT1, MYL1, MYH11, MYH7, MYBPC2, ACTA1, MYH14, NEB, MYH3, MYL2, ACTG2, MYL4, TPM2, ACTA2, ACTC1, TNNI3, MYL9, TNNT2, MYL12B, ACTN2, TTN, DES, TPM3, TNNC1, TNNI2, UBC, TPM4
MYH6	MYPN	No	-	3	ACTN2, TTN, NEB
MYH6	TNNI3	Yes	binding	33	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYH3, MYH1, MYBPC1, TPM2, MYLPF, MYL1, MYH11, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, ACTC1, TNNT2, MYBPC3, MYL3, ACTN2, PROC, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
MYH6	DSG2	No	-	1	UBC
MYH6	TTN	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TNNI2, UBC, TPM4
MYH6	VCL	No	-	15	ACTN2, TPM1, MYH11, ACTA2, TTN, ACTA1, TPM3, MYL9, HSP90AA1, ACTG2, UBC, MYL12B, MYL6B, TPM4, TPM2
MYH6	LDB3	No	-	1	ACTN2
MYH6	CSRP3	No	-	1	MYOD1
MYH6	ACTN2	Yes	binding	30	TPM1, TMOD1, TNNI1, MYH8, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, ACTA2, MYBPC2, ACTA1, NEB, MYH3, TNNC2, MYL4, TNNT1, TNNI3, MYH7, MYBPC3, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, UBC, TPM4
MYH6	MYBPC3	Yes	binding	40	TPM1, TMOD1, MYH13, MYL4, MYOM1, TNNT3, VIM, MYL3, MYH1, MYL6B, TNNC2, MYLPF, MYL1, MYH11, MYH7, MYBPC2, TNNI1, MYH2, MYH14, NEB, MYL2, MYH8, TPM2, MYL5, TPM3, TNNT1, MYH4, TNNI3, MYL9, TNNT2, MYBPC1, MYH10, ACTN2, TNNC1, DES, MYH9, MYH3, TTN, TNNI2, TPM4
MYH6	SDHA	No	-	1	UBC
MYH7	TPM1	Yes	binding	27	MYH8, TNNT3, TPM3, MYL6B, MYBPC3, TPM2, MYL1, MYH11, MYL3, ACTA1, MYH1, MYH14, TNNC2, ACTG2, MYH6, ACTA2, ACTC1, TNNI3, MYL9, TNNT2, MYL12B, ACTN2, MYL2, TNNC1, TNNI1, MYH3, TNNI2
MYH7	MYPN	No	-	1	ACTN2
MYH7	TNNI3	Yes	binding	22	TPM1, MYH8, TNNT3, MYH3, TPM2, MYLPF, MYL1, MYH11, MYL3, MYH1, MYH14, TNNC2, TPM3, ACTC1, TNNT2, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, MYH6, TNNI2
MYH7	TTN	No	-	19	ACTN2, TNNI3, TPM1, TNNT2, MYL3, MYL2, TNNC1, MYH8, MYL1, TNNI1, MYH14, MYH3, TNNI2, TNNT3, TNNC2, TPM3, MYH6, MYBPC3, TPM2
MYH7	VCL	No	-	12	ACTN2, TPM1, MYH11, ACTA2, ACTA1, TPM3, MYL9, HSP90AA1, ACTG2, MYL12B, MYL6B, TPM2
MYH7	LDB3	No	-	1	ACTN2
MYH7	ACTN2	Yes	binding	19	TNNI3, TPM1, TNNT2, TPM3, ACTA2, TNNC1, TNNI1, MYH8, ACTA1, MYL1, MYH3, TNNI2, TNNT3, TNNC2, MYH6, MYL2, MYBPC3, TPM2, MYL3
MYH7	MYBPC3	Yes	binding	30	TPM1, TNNI1, MYH8, MYOM1, MYH9, TPM3, MYL6B, TPM2, MYLPF, MYL1, MYH11, MYH6, MYH1, MYH14, TNNC2, MYL5, MYH2, MYH4, TNNI3, MYL9, TNNT2, MYL3, ACTN2, MYL2, TNNC1, MYH13, TNNT3, MYH3, TNNI2, MYH10
PSEN2	PSEN1	Yes	activation, binding	24	BCL2L1, EIF2AK3, KCNIP4, FLNC, DLL1, SRI, NOTCH3, NOTCH4, UBQLN1, KCNIP3, METTL2B, DNER, ATF6, APH1B, RYR2, NCSTN, ICAM5, TRAF6, MTCH1, NOTCH1, FLNB, PSENEN, UBC, ERN1
PSEN2	TPM1	No	-	1	UBC
PSEN2	DSG2	No	-	1	UBC
PSEN2	TTN	No	-	2	UBC, FHL2
PSEN2	VCL	No	-	2	UBC, CAPN1
PSEN2	ACTN2	No	-	2	UBC, CAPN1
PSEN2	SDHA	No	-	1	UBC
PSEN1	TPM1	No	-	1	UBC
PSEN1	TNNI3	No	-	4	PRKACG, PRKACB, PRKACA, PRKX
PSEN1	DSG2	No	-	1	UBC
PSEN1	EYA4	No	-	1	ERBB4
PSEN1	TTN	No	-	1	UBC
PSEN1	VCL	No	-	7	CTNNB1, CTNNA3, CDH1, UBC, CTNND1, CDH2, SRC
PSEN1	CSRP3	No	-	1	MYOD1
PSEN1	ACTN2	No	-	5	SRC, UBC, GRB2, CTNNA3, APP
PSEN1	SDHA	No	-	1	UBC
PSEN1	PLN	No	-	4	PRKACG, PRKACB, PRKACA, PRKX
TPM1	MYPN	No	-	3	ACTN2, TTN, NEB
TPM1	TNNI3	Yes	binding	31	TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, MYBPC1, TPM2, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, MYH7, TNNT2, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TPM1	DSG2	No	-	1	UBC
TPM1	TTN	Yes	binding	31	TMOD1, TNNI1, MYL4, VCL, ACTN1, TNNT3, VIM, MYL3, TLN1, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, TNNC1, DES, TPM3, TNNI2, UBC, TPM4
TPM1	VCL	Yes	binding	24	CALD1, ACTN4, TLN1, MYH11, ACTN1, MYL6B, ACTA1, TPM2, ITGB5, SORBS3, ACTG2, ACTA2, MYL9, PXN, MYL12B, ACTN2, MYL6, TTN, SORBS1, TPM3, ITGA1, LMOD1, UBC, TPM4
TPM1	LDB3	No	-	3	ACTN2, ACTN4, ACTN1
TPM1	ACTN2	Yes	binding	38	TMOD1, TNNI1, MYH8, VCL, ACTN1, PXN, TNNT3, VIM, MYL3, TLN1, ACTN4, MYBPC1, TPM2, MYL1, TNNT2, ACTA2, MYBPC2, ACTA1, NEB, MYH3, TNNC2, ITGB5, MYH6, MYL4, TNNT1, SPTBN1, TNNI3, MYH7, MYBPC3, MYL2, TTN, DES, TPM3, ITGA1, TNNC1, TNNI2, UBC, TPM4
TPM1	MYBPC3	Yes	binding	32	TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, MYL6B, TPM2, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYL9, MYH7, TNNT2, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TPM1	SDHA	No	-	1	UBC
MYPN	TNNI3	No	-	3	ACTN2, TTN, NEB
MYPN	TTN	Yes	binding	4	ACTN2, ANKRD1, NEB, ANKRD23
MYPN	VCL	No	-	2	ACTN2, TTN
MYPN	LDB3	No	-	1	ACTN2
MYPN	ACTN2	Yes	binding	2	TTN, NEB
MYPN	MYBPC3	No	-	3	ACTN2, TTN, NEB
TNNI3	TTN	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TNNI2, TPM4
TNNI3	VCL	No	-	7	ACTN2, TPM1, MYH11, TTN, TPM3, TPM4, TPM2
TNNI3	LDB3	No	-	1	ACTN2
TNNI3	ACTN2	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, TPM3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, MYH7, MYBPC3, MYL3, MYL2, TNNC1, TNNI1, MYH3, TTN, TNNI2, TPM4
TNNI3	MYBPC3	Yes	binding	31	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, TPM2, MYLPF, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, MYH7, TNNT2, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TNNI3	PLN	No	-	4	PRKACA, PRKACB, PRKACG, PRKX
DSG2	TTN	No	-	1	UBC
DSG2	VCL	No	-	2	UBC, JUP
DSG2	ACTN2	No	-	1	UBC
DSG2	SDHA	No	-	1	UBC
TTN	VCL	Yes	reaction, binding	15	ACTN2, TPM1, ACTN1, SOD1, HABP4, WDR1, TPM3, TUBA4A, TLN1, POTEI, PLEK, UBC, BRPF3, TPM4, TPM2
TTN	LDB3	No	-	3	ACTN2, ANKRD2, ACTN1
TTN	ACTN2	Yes	binding	31	TPM1, TMOD1, TNNI1, MYL4, VCL, ACTN1, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, TLN1, MYH6, MYH8, TNNC2, TNNT1, MYPN, TNNI3, MYBPC3, MYL2, TNNC1, DES, TPM3, TNNI2, UBC, TPM4
TTN	MYBPC3	Yes	binding	27	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC1, ACTN2, MYL2, TNNC1, DES, TPM3, TNNI2, TPM4
TTN	SDHA	No	-	1	UBC
VCL	LDB3	No	-	3	ACTN2, ACTN4, ACTN1
VCL	ACTN2	Yes	binding	31	ZYX, TNS1, CTNNA1, LPP, PXN, PTK2, ACTN4, TPM2, CTNNA3, ITGB1, RHOA, ACTN1, ACTA1, CSK, TLN1, ITGB5, TRIP6, CAPN1, ACTA2, SRC, TPM1, TTN, CTNNA2, TPM3, ITGA1, PIK3R1, CRKL, PIK3CA, UBC, TPM4, BCAR1
VCL	MYBPC3	No	-	9	ACTN2, TPM1, MYH11, TTN, TPM3, MYL9, TPM4, MYL6B, TPM2
VCL	SDHA	No	-	1	UBC
LDB3	ACTN2	Yes	binding	4	ACTN4, MYOZ2, MYOZ1, ACTN1
LDB3	MYBPC3	No	-	1	ACTN2
ACTN2	MYBPC3	Yes	binding	27	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
ACTN2	SDHA	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
RAF1	VCL	No	-	1	SRC
PSEN2	PSEN1	No	-	4	APH1B, NCSTN, APH1A, PSENEN

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ACTC1	TPM1	Yes	1	ACTA2
PSEN1	SDHA	No	1	NDUFS8

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
TNNC1	TNNT2	Yes	3	TNNC1, TNNI3, TNNT2
TNNC1	TNNI3	Yes	3	TNNC1, TNNI3, TNNT2
TNNT2	TNNI3	Yes	3	TNNC1, TNNI3, TNNT2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Dilated cardiomyopathy	hsa05414	6.08	14	PLN, SGCD, TNNT2, MYH7, TNNC1, ACTC1, DES, TPM1, MYH6, TNNI3, TTN, LMNA, DMD, MYBPC3
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	13	TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, SGCD, MYH6, TNNI3, TTN, LMNA, MYBPC3, DMD
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	9	PLN, TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, SCN5A
Cardiac muscle contraction	hsa04260	6.34	7	TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32	6	ACTN2, SGCD, DES, DSG2, LMNA, DMD
Viral myocarditis	hsa05416	6.45	4	MYH7, DMD, SGCD, MYH6
Focal adhesion	hsa04510	4.92	4	ACTN2, LAMA4, RAF1, VCL
cGMP-PKG signaling pathway	hsa04022	5.32	3	PLN, MYH7, RAF1
cAMP signaling pathway	hsa04024	5.05	3	PLN, TNNI3, RAF1
Tight junction	hsa04530	5.53	3	ACTN2, MYH7, MYH6
Neurotrophin signaling pathway	hsa04722	5.78	3	PSEN2, RAF1, PSEN1
Amoebiasis	hsa05146	5.82	3	ACTN2, LAMA4, VCL
Thyroid hormone signaling pathway	hsa04919	5.82	3	PLN, RAF1, MYH6
Alzheimer's disease	hsa05010	5.34	3	PSEN2, PSEN1, SDHA
Regulation of actin cytoskeleton	hsa04810	4.9	3	ACTN2, VCL, RAF1
Calcium signaling pathway	hsa04020	5.22	2	PLN, TNNC1
MicroRNAs in cancer	hsa05206	5.38	2	TPM1, RAF1
Pathways in cancer	hsa05200	3.98	2	LAMA4, RAF1
Leukocyte transendothelial migration	hsa04670	5.74	2	ACTN2, VCL
Notch signaling pathway	hsa04330	7.12	2	PSEN2, PSEN1
Adherens junction	hsa04520	6.26	2	ACTN2, VCL
PI3K-Akt signaling pathway	hsa04151	4.21	2	LAMA4, RAF1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Human Diseases	NEW	1.54	0.0	TPM1, SGCD, VCL, MYH6, DMD, PLN, TNNT2, LMNA, CRYAB, RAF1, MYH7, ACTC1, PSEN1, TNNI3, SDHA, SCN5A, MYBPC3, BAG3, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, PSEN2
Cellular Processes	NEW	2.22	0.01	ACTN2, PLN, TPM1, TNNT2, MYH6, MYH7, CSRP3, DES, LAMA4, ACTC1, CRYAB, PSEN1, LMNA, TNNI3, RAF1, VCL, LDB3, PSEN2, SCN5A, DMD, MYBPC3
Cardiovascular diseases	NEW	5.06	0.0	ACTN2, PLN, SGCD, TNNT2, DSG2, MYH7, TNNC1, ACTC1, PSEN1, CRYAB, VCL, TNNI3, TTN, DES, MYH6, LMNA, DMD, MYBPC3, TPM1
Cardiac muscle contraction (hsa04260)	-	6.34	0.0	ACTN2, TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3
Calcium signaling pathway (hsa04020)	-	5.22	0.002	ACTN2, PLN, TPM1, TNNT2, TNNC1, DES, RAF1, DMD
Signal transduction	NEW	2.06	0.004	TPM1, VCL, DMD, PLN, TNNT2, LMNA, CRYAB, RAF1, MYH7, ACTC1, PSEN1, TNNI3, PSEN2, SCN5A, MYBPC3, BAG3, ACTN2, CSRP3, TNNC1, LAMA4, DES, ABCC9
Dilated cardiomyopathy (hsa05414)	-	6.08	0.0	ACTN2, PLN, SGCD, TNNT2, MYH7, TNNC1, ACTC1, DES, TPM1, MYH6, TNNI3, TTN, LMNA, DMD, MYBPC3
Leukocyte transendothelial migration (hsa04670)	-	5.74	0.018	ACTN2, TNNT2, VCL, MYH6, DMD, MYBPC3
Circulatory system	NEW	4.63	0.0	ACTN2, PLN, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, CSRP3, PSEN1, TNNI3, MYH6, RAF1, SCN5A, DMD
Focal adhesion (hsa04510)	-	4.92	0.007	ACTN2, TPM1, TNNT2, LAMA4, VCL, MYH6, RAF1, DMD
Cellular community	NEW	3.57	0.019	ACTN2, CSRP3, CRYAB, TNNT2, RAF1, MYH7, LAMA4, PSEN1, TPM1, VCL, MYH6, LDB3, DMD
Hypertrophic cardiomyopathy (HCM) (hsa05410)	-	6.21	0.0	ACTN2, SGCD, TNNT2, MYH7, TNNC1, DES, ACTC1, CRYAB, TPM1, TNNI3, TTN, MYH6, LMNA, DMD, MYBPC3
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412)	-	6.32	0.0	ACTN2, SGCD, DSG2, DES, VCL, PSEN1, LMNA, DMD
Alzheimer's disease (hsa05010)	-	5.34	0.036	ACTN2, TPM1, SDHA, PSEN1, RAF1, PSEN2
Adrenergic signaling in cardiomyocytes (hsa04261)	-	5.44	0.0	ACTN2, PLN, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, SCN5A, DMD
Viral myocarditis (hsa05416)	-	6.45	0.019	TNNI3, MYH7, DMD, SGCD, MYH6

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Muscle contraction	R-HSA-397014	6.96	12	ACTN2, TPM1, TNNT2, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, VCL, MYBPC3, DMD
Striated Muscle Contraction	R-HSA-390522	7.81	11	ACTN2, TPM1, TNNT2, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, DMD, MYBPC3
Axon guidance	R-HSA-422475	3.93	5	PSEN2, ACTN2, SCN5A, VCL, RAF1
Developmental Biology	R-HSA-1266738	3.48	5	PSEN2, ACTN2, SCN5A, RAF1, VCL
Signaling by ERBB4	R-HSA-1236394	4.7	4	PSEN2, ACTN2, VCL, RAF1
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	4	ACTN2, TTN, VCL, RAF1
Signal Transduction	R-HSA-162582	1.78	4	ACTN2, PSEN2, VCL, RAF1
Signalling by NGF	R-HSA-166520	4.23	4	PSEN2, ACTN2, RAF1, VCL
Hemostasis	R-HSA-109582	3.98	4	ACTN2, TTN, VCL, RAF1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	3	ACTN2, VCL, RAF1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	ACTN2, VCL, RAF1
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	3	ACTN2, RAF1, VCL
Platelet degranulation	R-HSA-114608	6.68	3	ACTN2, TTN, VCL
Signaling by Interleukins	R-HSA-449147	4.71	3	ACTN2, VCL, RAF1
Immune System	R-HSA-168256	2.37	3	ACTN2, VCL, RAF1
Frs2-mediated activation	R-HSA-170968	5.12	3	ACTN2, VCL, RAF1
Transmembrane transport of small molecules	R-HSA-382551	3.79	3	PLN, ABCC9, RAF1
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	ACTN2, VCL, RAF1
Extracellular matrix organization	R-HSA-1474244	4.91	3	DMD, LAMA4, PSEN1
IGF1R signaling cascade	R-HSA-2428924	4.85	3	ACTN2, VCL, RAF1
Downstream signal transduction	R-HSA-186763	4.65	3	ACTN2, VCL, RAF1
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	3	ACTN2, VCL, RAF1
Signaling by Insulin receptor	R-HSA-74752	4.73	3	ACTN2, RAF1, VCL
Insulin receptor signalling cascade	R-HSA-74751	4.85	3	ACTN2, RAF1, VCL
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	ACTN2, VCL, RAF1
MAPK family signaling cascades	R-HSA-5683057	4.89	3	ACTN2, VCL, RAF1
Signaling by Leptin	R-HSA-2586552	5.1	3	ACTN2, VCL, RAF1
Signaling by VEGF	R-HSA-194138	4.66	3	ACTN2, VCL, RAF1
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	3	ACTN2, RAF1, VCL
FCERI mediated MAPK activation	R-HSA-2871796	4.32	3	ACTN2, VCL, RAF1
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	3	ACTN2, TTN, VCL
IRS-mediated signalling	R-HSA-112399	4.87	3	ACTN2, RAF1, VCL
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	3	ACTN2, VCL, RAF1
DAP12 interactions	R-HSA-2172127	4.56	3	ACTN2, VCL, RAF1
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	3	ACTN2, VCL, RAF1
Neuronal System	R-HSA-112316	4.82	3	ACTN2, ABCC9, RAF1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	ACTN2, RAF1, VCL
RAF/MAP kinase cascade	R-HSA-5673001	5.15	3	ACTN2, VCL, RAF1
Signaling by FGFR4	R-HSA-5654743	4.69	3	ACTN2, VCL, RAF1
Signaling by FGFR3	R-HSA-5654741	4.69	3	ACTN2, VCL, RAF1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	3	ACTN2, VCL, RAF1
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	3	ACTN2, RAF1, VCL
Signaling by FGFR	R-HSA-190236	4.67	3	ACTN2, VCL, RAF1
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	ACTN2, VCL, RAF1
Interleukin-2 signaling	R-HSA-451927	5.05	3	ACTN2, RAF1, VCL
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	ACTN2, VCL, RAF1
Interleukin receptor SHC signaling	R-HSA-912526	5.09	3	ACTN2, VCL, RAF1
Innate Immune System	R-HSA-168249	3.17	3	ACTN2, RAF1, VCL
Signaling by SCF-KIT	R-HSA-1433557	4.73	3	ACTN2, RAF1, VCL
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	3	ACTN2, VCL, RAF1
Signaling by PDGF	R-HSA-186797	4.53	3	ACTN2, VCL, RAF1
Signalling to RAS	R-HSA-167044	5.08	3	ACTN2, RAF1, VCL
DAP12 signaling	R-HSA-2424491	4.64	3	ACTN2, RAF1, VCL
SHC1 events in EGFR signaling	R-HSA-180336	5.15	3	ACTN2, VCL, RAF1
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	3	ACTN2, VCL, RAF1
SOS-mediated signalling	R-HSA-112412	5.15	3	ACTN2, VCL, RAF1
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	ACTN2, VCL, RAF1
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	3	ACTN2, VCL, RAF1
Signaling by EGFR	R-HSA-177929	4.59	3	ACTN2, VCL, RAF1
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	ACTN2, VCL, RAF1
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	3	ACTN2, RAF1, VCL
Prolonged ERK activation events	R-HSA-169893	5.11	3	ACTN2, VCL, RAF1
Signalling to ERKs	R-HSA-187687	5.04	3	ACTN2, VCL, RAF1
Signaling by GPCR	R-HSA-372790	2.68	3	ACTN2, VCL, RAF1
Signaling by FGFR2	R-HSA-5654738	4.68	3	ACTN2, VCL, RAF1
GRB2 events in EGFR signaling	R-HSA-179812	5.15	3	ACTN2, VCL, RAF1
Signaling by FGFR1	R-HSA-5654736	4.69	3	ACTN2, VCL, RAF1
ARMS-mediated activation	R-HSA-170984	5.12	3	ACTN2, RAF1, VCL
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	3	ACTN2, VCL, RAF1
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	ACTN2, VCL, RAF1
Signaling by ERBB2	R-HSA-1227986	4.66	3	ACTN2, VCL, RAF1
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	3	ACTN2, VCL, RAF1
Initiation of Nuclear Envelope Reformation	R-HSA-2995383	9.28	2	TMPO, LMNA
MAP2K and MAPK activation	R-HSA-5674135	7.66	2	RAF1, VCL
Apoptotic execution phase	R-HSA-75153	7.28	2	LMNA, DSG2
Programmed Cell Death	R-HSA-5357801	5.65	2	LMNA, DSG2
Post NMDA receptor activation events	R-HSA-438064	7.85	2	ACTN2, RAF1
Cell Cycle	R-HSA-1640170	3.89	2	LMNA, TMPO
CREB phosphorylation through the activation of Ras	R-HSA-442742	8.23	2	ACTN2, RAF1
Disease	R-HSA-1643685	3.33	2	PSEN2, ABCC9
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.45	2	LMNA, TMPO
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73	2	LMNA, DSG2
Cell Cycle, Mitotic	R-HSA-69278	4.16	2	LMNA, TMPO
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.1	2	LAMA4, DMD
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	R-HSA-112314	5.85	2	ACTN2, RAF1
Transmission across Chemical Synapses	R-HSA-112315	5.28	2	ACTN2, RAF1
Ion channel transport	R-HSA-983712	5.34	2	PLN, RAF1
Membrane Trafficking	R-HSA-199991	5.26	2	MYH7, MYH6
M Phase	R-HSA-68886	4.87	2	TMPO, LMNA
Translocation of GLUT4 to the plasma membrane	R-HSA-1445148	6.77	2	MYH7, MYH6
Mitotic Anaphase	R-HSA-68882	5.46	2	LMNA, TMPO
Clearance of Nuclear Envelope Membranes from Chromatin	R-HSA-2993913	9.81	2	TMPO, LMNA
Activation of NMDA receptor upon glutamate binding and postsynaptic events	R-HSA-442755	7.7	2	ACTN2, RAF1
Vesicle-mediated transport	R-HSA-5653656	4.33	2	MYH7, MYH6
Depolymerisation of the Nuclear Lamina	R-HSA-4419969	9.08	2	LMNA, TMPO
Nuclear Envelope Reassembly	R-HSA-2995410	9.28	2	LMNA, TMPO
Smooth Muscle Contraction	R-HSA-445355	8.23	2	TPM1, VCL
Nuclear Envelope Breakdown	R-HSA-2980766	7.34	2	TMPO, LMNA
Apoptosis	R-HSA-109581	5.68	2	LMNA, DSG2
Mitotic Prophase	R-HSA-68875	6.27	2	LMNA, TMPO

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Muscle contraction (R-HSA-397014)	-	6.96	0.0	ACTN2, TPM1, TNNT2, TNNC1, DES, ACTC1, VCL, TNNI3, TTN, MYH6, DMD, MYBPC3
Striated Muscle Contraction (R-HSA-390522)	-	7.81	0.0	ACTN2, TPM1, TNNT2, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, DMD, MYBPC3
Smooth Muscle Contraction (R-HSA-445355)	-	8.23	0.027	TPM1, MYH6, VCL

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	34	EYA4, TPM1, VCL, GATAD1, TMPO, DMD, PLN, TNNT2, MYH6, MYPN, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, BAG3, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, PSEN2
protein binding (GO:0005515)	0.46	32	EYA4, TPM1, VCL, TMPO, DMD, PLN, TNNT2, MYH6, MYPN, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, BAG3, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, PSEN2
cytoskeletal protein binding (GO:0008092)	3.02	19	ACTN2, CSRP3, CRYAB, TNNT2, MYH7, TTN, DES, MYPN, TPM1, VCL, TNNC1, TNNI3, ACTC1, MYH6, LDB3, SCN5A, DMD, MYBPC3, NEXN
cation binding (GO:0043169)	1.4	15	ACTN2, CSRP3, CRYAB, LDB3, TNNC1, EYA4, DSG2, TNNI3, TTN, GATAD1, RAF1, PRDM16, DMD, MYBPC3, RBM20
metal ion binding (GO:0046872)	1.41	15	ACTN2, CSRP3, CRYAB, LDB3, TTN, EYA4, DSG2, TNNI3, TNNC1, GATAD1, RAF1, PRDM16, DMD, MYBPC3, RBM20
ion binding (GO:0043167)	1.36	15	ACTN2, CSRP3, CRYAB, LDB3, TNNC1, EYA4, DSG2, TNNI3, TTN, GATAD1, RAF1, PRDM16, DMD, MYBPC3, RBM20
actin binding (GO:0003779)	3.74	13	ACTN2, TPM1, TNNT2, MYH6, MYH7, TNNC1, VCL, TNNI3, TTN, MYPN, DMD, MYBPC3, NEXN
catalytic activity (GO:0003824)	1.05	13	EYA4, TNNT2, FKTN, MYH7, TTN, ACTC1, PSEN1, ABCC9, RAF1, MYH6, PRDM16, PSEN2, SDHA
organic cyclic compound binding (GO:0097159)	1.05	12	RBM20, RAF1, MYH7, TTN, ACTC1, MYH6, GATAD1, TMPO, PRDM16, ABCC9, BAG3, SDHA
heterocyclic compound binding (GO:1901363)	1.06	12	RBM20, RAF1, MYH7, TTN, ACTC1, MYH6, GATAD1, TMPO, PRDM16, ABCC9, BAG3, SDHA
structural molecule activity (GO:0005198)	3.1	12	ACTN2, CSRP3, CRYAB, TTN, LAMA4, DES, TPM1, VCL, LMNA, DMD, MYBPC3, NEXN
enzyme binding (GO:0019899)	2.27	10	PLN, SCN5A, LMNA, TTN, VCL, TNNI3, RAF1, MYH6, LDB3, DMD
small molecule binding (GO:0036094)	1.89	9	MYH7, TTN, ACTC1, MYH6, BAG3, RAF1, ABCC9, RBM20, SDHA
hydrolase activity (GO:0016787)	1.9	9	EYA4, TNNT2, MYH7, ACTC1, PSEN1, ABCC9, MYH6, RAF1, PSEN2
identical protein binding (GO:0042802)	2.63	9	ACTN2, PLN, CRYAB, MYH7, TNNC1, DES, TTN, RAF1, MYBPC3
nucleoside phosphate binding (GO:1901265)	1.96	9	MYH7, TTN, ACTC1, MYH6, BAG3, RAF1, ABCC9, RBM20, SDHA
nucleotide binding (GO:0000166)	1.96	9	MYH7, TTN, ACTC1, MYH6, BAG3, RAF1, ABCC9, RBM20, SDHA
carbohydrate derivative binding (GO:0097367)	2.03	8	MYH7, TTN, ACTC1, VCL, MYH6, RAF1, ABCC9, DMD
purine nucleotide binding (GO:0017076)	2.19	7	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9, BAG3
structural constituent of muscle (GO:0008307)	6.02	7	ACTN2, CSRP3, TTN, TPM1, DMD, MYBPC3, NEXN
adenyl nucleotide binding (GO:0030554)	2.4	7	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9, BAG3
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
protein complex binding (GO:0032403)	3.09	6	ACTN2, TNNC1, VCL, TTN, BAG3, NEXN
protein kinase binding (GO:0019901)	3.44	6	SCN5A, LDB3, TTN, MYH6, TNNI3, RAF1
kinase binding (GO:0019900)	3.32	6	SCN5A, LDB3, TTN, MYH6, TNNI3, RAF1
macromolecular complex binding (GO:0044877)	2.61	6	ACTN2, TTN, VCL, TNNC1, BAG3, NEXN
ribonucleotide binding (GO:0032553)	2.19	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
purine nucleoside binding (GO:0001883)	2.22	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
ribonucleoside binding (GO:0032549)	2.22	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
purine ribonucleotide binding (GO:0032555)	2.2	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
adenyl ribonucleotide binding (GO:0032559)	2.41	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
molecular function regulator (GO:0098772)	2.51	6	ACTN2, PLN, TNNI3, ABCC9, MYBPC3, BAG3
purine ribonucleoside binding (GO:0032550)	2.22	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
ATP binding (GO:0005524)	2.43	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
nucleoside binding (GO:0001882)	2.21	6	MYH7, TTN, ACTC1, MYH6, RAF1, ABCC9
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	5	ABCC9, TNNT2, ACTC1, MYH7, MYH6
ATPase activity (GO:0016887)	3.65	5	ABCC9, TNNT2, ACTC1, MYH7, MYH6
transition metal ion binding (GO:0046914)	2.48	5	RBM20, CSRP3, GATAD1, DMD, LDB3
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	5	ABCC9, TNNT2, ACTC1, MYH7, MYH6
actin filament binding (GO:0051015)	4.93	5	ACTN2, TNNC1, NEXN, TTN, VCL
nucleoside-triphosphatase activity (GO:0017111)	3.09	5	ABCC9, TNNT2, ACTC1, MYH7, MYH6
pyrophosphatase activity (GO:0016462)	3.04	5	ABCC9, TNNT2, ACTC1, MYH7, MYH6
zinc ion binding (GO:0008270)	2.66	5	RBM20, CSRP3, GATAD1, DMD, LDB3
nucleic acid binding (GO:0003676)	1.44	5	RBM20, GATAD1, RAF1, TMPO, PRDM16
protein dimerization activity (GO:0046983)	2.72	5	ACTN2, TNNC1, CRYAB, MYH7, RAF1
protein domain specific binding (GO:0019904)	3.32	5	ACTN2, TNNI3, SCN5A, MYPN, PSEN1
calcium ion binding (GO:0005509)	3.17	4	ACTN2, TTN, DSG2, TNNC1
transferase activity (GO:0016740)	1.95	4	TTN, FKTN, RAF1, PRDM16
calmodulin binding (GO:0005516)	4.55	4	TTN, SCN5A, MYH7, MYH6
actinin binding (GO:0042805)	6.3	4	TTN, CSRP3, MYPN, LDB3
cell adhesion molecule binding (GO:0050839)	4.5	4	ACTN2, VCL, PSEN1, DSG2
protein homodimerization activity (GO:0042803)	3.16	4	ACTN2, TNNC1, CRYAB, MYH7
structural constituent of cytoskeleton (GO:0005200)	5.12	3	DMD, DES, TPM1
cation channel activity (GO:0005261)	4.04	3	ABCC9, SCN5A, PSEN1
myosin binding (GO:0017022)	5.66	3	DMD, ACTC1, MYBPC3
ATPase regulator activity (GO:0060590)	6.34	3	PLN, MYBPC3, BAG3
DNA binding (GO:0003677)	1.92	3	GATAD1, TMPO, PRDM16
ion channel binding (GO:0044325)	5.02	3	ACTN2, ABCC9, SCN5A
ATPase activity, coupled (GO:0042623)	3.97	3	ABCC9, MYH7, MYH6
channel regulator activity (GO:0016247)	4.88	3	PLN, TNNI3, ABCC9
passive transmembrane transporter activity (GO:0022803)	3.6	3	ABCC9, SCN5A, PSEN1
metal ion transmembrane transporter activity (GO:0046873)	3.71	3	ABCC9, SCN5A, PSEN1
enzyme regulator activity (GO:0030234)	2.85	3	PLN, MYBPC3, BAG3
alpha-actinin binding (GO:0051393)	6.6	3	TTN, MYPN, LDB3
transporter activity (GO:0005215)	2.57	3	ABCC9, SCN5A, PSEN1
ion channel activity (GO:0005216)	3.71	3	ABCC9, SCN5A, PSEN1
cation transmembrane transporter activity (GO:0008324)	3.32	3	ABCC9, SCN5A, PSEN1
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	EYA4, MYH6, RAF1
nucleoside-triphosphatase regulator activity (GO:0060589)	3.92	3	PLN, MYBPC3, BAG3
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	3	ABCC9, SCN5A, PSEN1
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	3	ABCC9, SCN5A, PSEN1
substrate-specific transporter activity (GO:0022892)	2.72	3	ABCC9, SCN5A, PSEN1
muscle alpha-actinin binding (GO:0051371)	7.54	3	TTN, MYPN, LDB3
ion transmembrane transporter activity (GO:0015075)	3.04	3	ABCC9, SCN5A, PSEN1
transmembrane transporter activity (GO:0022857)	2.82	3	ABCC9, SCN5A, PSEN1
channel activity (GO:0015267)	3.6	3	ABCC9, SCN5A, PSEN1
substrate-specific channel activity (GO:0022838)	3.67	3	ABCC9, SCN5A, PSEN1
endopeptidase activity (GO:0004175)	3.63	2	PSEN2, PSEN1
phosphatase activity (GO:0016791)	4.11	2	EYA4, MYH6
calcium-dependent protein binding (GO:0048306)	5.68	2	TNNC1, TNNI3
troponin T binding (GO:0031014)	8.35	2	TNNC1, TNNI3
troponin I binding (GO:0031013)	8.13	2	TNNC1, TNNT2
phosphoric ester hydrolase activity (GO:0042578)	3.82	2	EYA4, MYH6
cadherin binding (GO:0045296)	6.41	2	VCL, PSEN1
signal transducer activity (GO:0004871)	2.28	2	ABCC9, RAF1
troponin C binding (GO:0030172)	8.64	2	TNNI3, TNNT2
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	SCN5A, VCL
peptidase activity (GO:0008233)	3.23	2	PSEN2, PSEN1
glycoprotein binding (GO:0001948)	5.11	2	DMD, VCL
sequence-specific DNA binding (GO:0043565)	2.79	2	GATAD1, PRDM16
microfilament motor activity (GO:0000146)	6.65	2	MYH7, MYH6
transcription coactivator activity (GO:0003713)	4.04	2	ACTN2, PRDM16
transcription cofactor activity (GO:0003712)	3.44	2	ACTN2, PRDM16
aspartic-type peptidase activity (GO:0070001)	6.1	2	PSEN2, PSEN1
protein serine/threonine kinase activity (GO:0004674)	3.64	2	TTN, RAF1
transcription factor activity, transcription factor binding (GO:0000989)	3.36	2	ACTN2, PRDM16
transcription factor activity, protein binding (GO:0000988)	3.35	2	ACTN2, PRDM16
protein kinase activity (GO:0004672)	3.27	2	TTN, RAF1
motor activity (GO:0003774)	4.81	2	MYH7, MYH6
telethonin binding (GO:0031433)	8.13	2	TTN, CSRP3
titin binding (GO:0031432)	7.25	2	ACTN2, MYBPC3
kinase activity (GO:0016301)	2.93	2	TTN, RAF1
actin-dependent ATPase activity (GO:0030898)	7.17	2	MYH7, MYH6
beta-catenin binding (GO:0008013)	5.3	2	VCL, PSEN1
nitric-oxide synthase binding (GO:0050998)	6.91	2	DMD, SCN5A
ubiquitin protein ligase binding (GO:0031625)	4.17	2	SCN5A, VCL
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	TTN, RAF1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	TTN, RAF1
phosphoprotein phosphatase activity (GO:0004721)	4.55	2	EYA4, MYH6
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	2	ABCC9, SCN5A
peptidase activity, acting on L-amino acid peptides (GO:0070011)	3.26	2	PSEN2, PSEN1
aspartic-type endopeptidase activity (GO:0004190)	6.13	2	PSEN2, PSEN1
calcium channel regulator activity (GO:0005246)	6.15	2	PLN, TNNI3
receptor binding (GO:0005102)	2.43	2	ACTN2, LAMA4
protein heterodimerization activity (GO:0046982)	3.64	2	MYH7, RAF1
dystroglycan binding (GO:0002162)	7.54	2	DMD, VCL

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
enzyme binding (GO:0019899)	-	2.27	0.031	ACTN2, PLN, TPM1, SCN5A, MYH6, TTN, ACTC1, DES, CRYAB, PSEN1, TNNI3, PSEN2, RAF1, VCL, LDB3, MYPN, DMD, BAG3
structural constituent of cytoskeleton (GO:0005200)	-	5.12	0.008	ACTN2, TPM1, TNNT2, DES, VCL, DMD
cation channel activity (GO:0005261)	-	4.04	0.01	ACTN2, SCN5A, ACTC1, PSEN1, TNNI3, ABCC9, PSEN2, DMD
calcium-dependent protein binding (GO:0048306)	-	5.68	0.002	ACTN2, TNNI3, TPM1, DES, TNNC1
troponin T binding (GO:0031014)	-	8.35	0.004	TNNI3, TNNC1
troponin I binding (GO:0031013)	-	8.13	0.0	TNNI3, TNNC1, TNNT2
alpha-actinin binding (GO:0051393)	-	6.6	0.0	TTN, ACTN2, VCL, MYPN, LDB3
dystroglycan binding (GO:0002162)	-	7.54	0.026	DMD, VCL
troponin C binding (GO:0030172)	-	8.64	0.002	TNNI3, TNNT2
ion channel binding (GO:0044325)	-	5.02	0.0	ACTN2, TPM1, SCN5A, DES, ABCC9, DMD
ankyrin binding (GO:0030506)	NEW	6.74	0.029	ACTN2, TTN, SCN5A
telethonin binding (GO:0031433)	-	8.13	0.0	ACTN2, TTN, CSRP3, MYH6
titin binding (GO:0031432)	-	7.25	0.046	ACTN2, DMD, MYBPC3, MYPN
microfilament motor activity (GO:0000146)	-	6.65	0.0	ACTN2, ACTC1, MYH7, MYH6
structural molecule activity (GO:0005198)	-	3.1	0.0	ACTN2, CSRP3, TPM1, TNNT2, MYH6, TTN, ACTC1, LAMA4, DES, CRYAB, PSEN1, LMNA, VCL, MYPN, RAF1, PSEN2, MYBPC3, DMD, NEXN
actin binding (GO:0003779)	-	3.74	0.0	ACTN2, TPM1, TNNT2, LMNA, MYH7, TTN, ACTC1, MYPN, CSRP3, VCL, TNNI3, TNNC1, MYH6, LDB3, SCN5A, DMD, MYBPC3, NEXN
transferase activity (GO:0016740)	-	1.95	0.008	VCL, FKTN, DMD, PLN, TNNT2, BAG3, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, MYH6, TTN, LDB3
calcium ion binding (GO:0005509)	-	3.17	0.0	ACTN2, TPM1, TNNT2, DSG2, MYH7, TTN, ACTC1, DES, CSRP3, MYH6, TNNI3, TNNC1, RAF1, PSEN1, MYPN, PSEN2, SCN5A, DMD, MYBPC3
channel inhibitor activity (GO:0016248)	NEW	6.13	0.004	ACTN2, TNNI3, DMD, SCN5A
protein complex binding (GO:0032403)	-	3.09	0.0	ACTN2, CRYAB, SCN5A, RAF1, NEXN, ACTC1, DES, TPM1, PSEN1, TNNI3, TTN, VCL, MYPN, LMNA, PSEN2, TNNC1, DMD, MYBPC3, BAG3
tropomyosin binding (GO:0005523)	NEW	7.1	0.0	ACTN2, TPM1, TNNT2, MYPN
ATP binding (GO:0005524)	-	2.43	0.037	ACTN2, PLN, CRYAB, TNNT2, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, TTN, VCL, PSEN1, RAF1, ABCC9, SCN5A, DMD, MYBPC3
kinase activity (GO:0016301)	-	2.93	0.015	ACTN2, PLN, CRYAB, TNNC1, DES, ACTC1, CSRP3, PSEN1, TNNI3, TTN, MYH6, RAF1, DMD, NEXN
inorganic cation transmembrane transporter activity (GO:0022890)	-	3.49	0.015	ACTN2, TPM1, SCN5A, ACTC1, PSEN1, TNNI3, PSEN2, ABCC9, DMD, NEXN
cation transmembrane transporter activity (GO:0008324)	-	3.32	0.018	ACTN2, TPM1, SCN5A, ACTC1, PSEN1, TNNI3, ABCC9, RAF1, PSEN2, DMD, NEXN
actin-dependent ATPase activity (GO:0030898)	-	7.17	0.0	ACTN2, ACTC1, MYH7, MYH6
protein kinase binding (GO:0019901)	-	3.44	0.033	ACTN2, PLN, CRYAB, SCN5A, MYH6, TTN, TPM1, PSEN1, TNNI3, RAF1, VCL, LDB3, DMD
kinase binding (GO:0019900)	-	3.32	0.001	ACTN2, PLN, CRYAB, SCN5A, MYH6, TTN, TPM1, VCL, TNNI3, RAF1, PSEN1, LDB3, DMD
structural constituent of muscle (GO:0008307)	-	6.02	0.0	ACTN2, TPM1, MYH7, TTN, DES, CSRP3, MYPN, DMD, MYBPC3, NEXN
actin filament binding (GO:0051015)	-	4.93	0.005	ACTN2, TTN, ACTC1, MYPN, TNNC1, VCL, LMNA, MYBPC3, NEXN
actinin binding (GO:0042805)	-	6.3	0.0	ACTN2, CSRP3, TTN, MYPN, VCL, LDB3
ion channel inhibitor activity (GO:0008200)	NEW	6.15	0.004	ACTN2, TNNI3, DMD, SCN5A
binding, bridging (GO:0060090)	NEW	4.57	0.007	ACTN2, TPM1, DES, VCL, RAF1, DMD, MYBPC3
nitric-oxide synthase binding (GO:0050998)	-	6.91	0.038	DMD, SCN5A
protein binding, bridging (GO:0030674)	NEW	4.68	0.004	ACTN2, TPM1, DES, VCL, RAF1, DMD, MYBPC3
cytoskeletal protein binding (GO:0008092)	-	3.02	0.0	ACTN2, CSRP3, CRYAB, TNNT2, RAF1, MYH7, TTN, ACTC1, DES, TPM1, MYH6, LMNA, TNNI3, TNNC1, MYBPC3, VCL, LDB3, SCN5A, MYPN, DMD, NEXN
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	-	3.08	0.021	ACTN2, PLN, CRYAB, TNNC1, ACTC1, DES, CSRP3, PSEN1, TNNI3, TTN, MYH6, RAF1, NEXN
muscle alpha-actinin binding (GO:0051371)	-	7.54	0.0	ACTN2, TTN, VCL, MYPN, LDB3
myosin binding (GO:0017022)	-	5.66	0.0	ACTN2, DMD, ACTC1, MYBPC3, MYH6
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	-	3.87	0.028	ACTN2, TPM1, SCN5A, PSEN1, TNNI3, ABCC9, DMD, NEXN
channel regulator activity (GO:0016247)	-	4.88	0.0	ACTN2, PLN, SCN5A, TNNI3, RAF1, ABCC9, DMD
calmodulin binding (GO:0005516)	-	4.55	0.0	ACTN2, TPM1, SCN5A, MYH7, TTN, MYH6, RAF1, DMD
protein binding (GO:0005515)	-	0.46	0.0	EYA4, TPM1, VCL, MYPN, DMD, PLN, TNNT2, MYH6, BAG3, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, TMPO, TTN, LDB3, PSEN2
calcium channel regulator activity (GO:0005246)	-	6.15	0.008	PLN, TNNI3, DMD, RAF1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	34	EYA4, SGCD, VCL, MYH6, FKTN, DMD, PLN, TNNT2, TPM1, MYPN, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, BAG3, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, PSEN2
single-organism process (GO:0044699)	0.48	33	EYA4, NEXN, SGCD, VCL, MYH6, FKTN, DMD, PLN, TNNT2, TPM1, MYPN, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, SDHA, PRDM16, SCN5A, MYBPC3, BAG3, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, ABCC9
biological regulation (GO:0065007)	0.39	32	EYA4, TPM1, VCL, GATAD1, TMPO, FKTN, DMD, PLN, TNNT2, MYH6, BAG3, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, PSEN2
regulation of biological process (GO:0050789)	0.45	32	EYA4, TPM1, VCL, GATAD1, TMPO, FKTN, DMD, PLN, TNNT2, MYH6, NEXN, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, PRDM16, SCN5A, MYBPC3, BAG3, ACTN2, CSRP3, TTN, LAMA4, DES, DSG2, TNNC1, PSEN2
single-organism cellular process (GO:0044763)	0.65	31	TPM1, SGCD, VCL, MYH6, FKTN, DMD, PLN, TNNT2, MYPN, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, BAG3, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, ABCC9
developmental process (GO:0032502)	1.36	29	EYA4, SGCD, VCL, DSG2, FKTN, DMD, PLN, TNNT2, TPM1, BAG3, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, MYH6, TTN
regulation of cellular process (GO:0050794)	0.5	29	EYA4, TPM1, VCL, GATAD1, TMPO, FKTN, DMD, PLN, TNNT2, MYH6, BAG3, RAF1, RBM20, CRYAB, LMNA, ACTC1, PSEN1, ABCC9, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DSG2, TTN, PSEN2
single-organism developmental process (GO:0044767)	1.49	26	EYA4, SGCD, VCL, FKTN, DMD, TNNT2, TPM1, BAG3, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, MYH6, TTN
anatomical structure development (GO:0048856)	1.58	24	EYA4, SGCD, SDHA, DSG2, FKTN, DMD, PLN, SCN5A, TPM1, RBM20, RAF1, CRYAB, LMNA, MYH7, PSEN1, TNNI3, BAG3, PRDM16, NEXN, ACTN2, CSRP3, TTN, LAMA4, MYH6
multicellular organismal process (GO:0032501)	1.45	23	EYA4, SGCD, VCL, MYH6, DMD, PLN, TNNT2, TPM1, RAF1, CRYAB, MYH7, ACTC1, PSEN1, TNNI3, PRDM16, SCN5A, MYBPC3, ACTN2, CSRP3, TNNC1, DES, DSG2, TTN
cellular component organization (GO:0016043)	1.24	22	EYA4, SGCD, VCL, MYH6, DMD, PLN, TNNT2, TPM1, MYPN, LMNA, CRYAB, RAF1, ACTC1, PSEN1, PRDM16, ACTN2, CSRP3, TTN, LAMA4, DES, DSG2, LDB3
cellular component organization or biogenesis (GO:0071840)	1.22	22	EYA4, SGCD, VCL, MYH6, DMD, PLN, TNNT2, TPM1, MYPN, LMNA, CRYAB, RAF1, ACTC1, PSEN1, PRDM16, ACTN2, CSRP3, TTN, LAMA4, DES, DSG2, LDB3
system process (GO:0003008)	2.3	20	ACTN2, PLN, TPM1, TNNT2, MYH7, CSRP3, TNNC1, DES, EYA4, ACTC1, SGCD, MYH6, TNNI3, TTN, VCL, PSEN1, CRYAB, SCN5A, MYBPC3, DMD
response to stimulus (GO:0050896)	1.22	18	PLN, CSRP3, CRYAB, TNNT2, RAF1, EYA4, TNNC1, ACTC1, TPM1, PSEN1, TTN, DSG2, LMNA, PSEN2, SCN5A, DMD, ABCC9, BAG3
regulation of multicellular organismal process (GO:0051239)	1.87	18	PLN, TPM1, TNNT2, MYH6, MYH7, TNNC1, LAMA4, DES, CSRP3, PSEN1, LMNA, TNNI3, DSG2, PRDM16, ABCC9, SCN5A, DMD, MYBPC3
muscle system process (GO:0003012)	4.18	17	ACTN2, PLN, CRYAB, TNNT2, MYH7, CSRP3, TNNC1, DES, ACTC1, TPM1, MYH6, TNNI3, TTN, VCL, SCN5A, DMD, MYBPC3
muscle contraction (GO:0006936)	4.37	16	ACTN2, CSRP3, CRYAB, TNNT2, MYH7, TTN, ACTC1, DES, TPM1, MYH6, TNNI3, TNNC1, VCL, SCN5A, DMD, MYBPC3
regulation of biological quality (GO:0065008)	1.68	15	ACTN2, PLN, TPM1, TNNT2, DSG2, MYH7, TNNC1, CSRP3, MYH6, TNNI3, PSEN1, RAF1, SCN5A, DMD, BAG3
actin filament-based process (GO:0030029)	3.94	15	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, CSRP3, MYH6, TNNI3, TTN, MYPN, LDB3, DMD, MYBPC3
regulation of metabolic process (GO:0019222)	1.02	15	ACTN2, CSRP3, CRYAB, MYH6, TTN, ACTC1, EYA4, TMPO, GATAD1, FKTN, RAF1, PSEN1, PRDM16, DMD, RBM20
regulation of macromolecule metabolic process (GO:0060255)	1.08	15	ACTN2, CSRP3, CRYAB, MYH6, TTN, ACTC1, EYA4, TMPO, GATAD1, FKTN, RAF1, PSEN1, PRDM16, DMD, RBM20
negative regulation of biological process (GO:0048519)	1.33	15	ACTN2, PLN, CRYAB, FKTN, CSRP3, ACTC1, TPM1, PSEN1, LMNA, RAF1, VCL, PRDM16, PSEN2, DMD, BAG3
regulation of molecular function (GO:0065009)	1.78	15	ACTN2, PLN, CRYAB, TNNT2, TNNC1, TPM1, PSEN1, TNNI3, TTN, MYH6, RAF1, PSEN2, DMD, MYBPC3, BAG3
regulation of localization (GO:0032879)	1.94	15	ACTN2, PLN, CRYAB, TNNT2, RAF1, TNNC1, LAMA4, TPM1, VCL, DSG2, LMNA, SCN5A, DMD, MYBPC3, NEXN
organelle organization (GO:0006996)	2.02	14	ACTN2, CSRP3, CRYAB, RAF1, TTN, ACTC1, DES, TPM1, PSEN1, LMNA, MYH6, LDB3, MYPN, DMD
regulation of primary metabolic process (GO:0080090)	1.08	14	ACTN2, CSRP3, CRYAB, MYH6, TTN, EYA4, PSEN1, GATAD1, FKTN, RAF1, TMPO, PRDM16, DMD, RBM20
regulation of system process (GO:0044057)	3.53	14	PLN, TPM1, TNNT2, MYH7, TNNC1, DES, CSRP3, DSG2, TNNI3, MYH6, ABCC9, SCN5A, DMD, MYBPC3
regulation of catalytic activity (GO:0050790)	1.97	14	ACTN2, PLN, CRYAB, TNNT2, TNNC1, TPM1, MYH6, TNNI3, TTN, PSEN1, RAF1, PSEN2, MYBPC3, BAG3
regulation of cellular metabolic process (GO:0031323)	1.07	14	ACTN2, CSRP3, CRYAB, MYH6, TTN, EYA4, PSEN1, GATAD1, FKTN, RAF1, TMPO, PRDM16, DMD, RBM20
cellular metabolic process (GO:0044237)	0.69	14	ACTN2, CRYAB, FKTN, MYH7, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2, DMD, RBM20, SDHA
movement of cell or subcellular component (GO:0006928)	2.61	14	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, VCL, PSEN1, DMD, MYBPC3
organic substance metabolic process (GO:0071704)	0.63	14	ACTN2, CRYAB, FKTN, MYH7, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2, DMD, RBM20, SDHA
animal organ development (GO:0048513)	2.53	14	RBM20, CSRP3, SGCD, FKTN, MYH7, CRYAB, PSEN1, LMNA, TNNI3, RAF1, MYH6, PRDM16, DMD, BAG3
metabolic process (GO:0008152)	0.58	14	ACTN2, CRYAB, FKTN, MYH7, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2, DMD, RBM20, SDHA
negative regulation of cellular process (GO:0048523)	1.41	14	ACTN2, CSRP3, TPM1, FKTN, ACTC1, CRYAB, PSEN1, LMNA, RAF1, VCL, PRDM16, PSEN2, DMD, BAG3
primary metabolic process (GO:0044238)	0.69	13	ACTN2, CRYAB, FKTN, MYH7, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2, RBM20, SDHA
single-organism organelle organization (GO:1902589)	2.68	13	ACTN2, CSRP3, CRYAB, RAF1, TTN, ACTC1, DES, TPM1, MYPN, LMNA, MYH6, LDB3, DMD
anatomical structure morphogenesis (GO:0009653)	2.53	13	TPM1, TNNT2, MYH6, MYH7, TNNC1, ACTC1, EYA4, VCL, TNNI3, TTN, PSEN1, SCN5A, MYBPC3
single-multicellular organism process (GO:0044707)	1.78	13	PLN, CSRP3, TPM1, SCN5A, DSG2, TNNC1, ACTC1, EYA4, MYH6, RAF1, PSEN1, PRDM16, DMD
cellular developmental process (GO:0048869)	1.82	13	ACTN2, SGCD, LMNA, TTN, LAMA4, CSRP3, PSEN1, TNNI3, RAF1, MYH6, PRDM16, DMD, NEXN
muscle filament sliding (GO:0030049)	6.09	12	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, DMD, MYBPC3
regulation of cellular component movement (GO:0051270)	3.08	12	PLN, TPM1, TNNT2, RAF1, TNNC1, LAMA4, VCL, DSG2, LMNA, SCN5A, MYBPC3, NEXN
cytoskeleton organization (GO:0007010)	3.22	12	ACTN2, CSRP3, CRYAB, LMNA, TTN, ACTC1, DES, TPM1, MYH6, RAF1, MYPN, LDB3
cellular macromolecule metabolic process (GO:0044260)	0.93	12	ACTN2, CRYAB, FKTN, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2, DMD, RBM20
regulation of gene expression (GO:0010468)	1.37	12	CSRP3, CRYAB, MYH6, ACTC1, EYA4, TMPO, GATAD1, RAF1, PSEN1, PRDM16, DMD, RBM20
regulation of heart contraction (GO:0008016)	4.35	12	PLN, TPM1, TNNT2, MYH7, DES, CSRP3, DSG2, TNNI3, MYH6, ABCC9, SCN5A, DMD
regulation of response to stimulus (GO:0048583)	1.54	12	ACTN2, PLN, CRYAB, FKTN, MYH7, TNNC1, PSEN1, LMNA, RAF1, PRDM16, DMD, BAG3
macromolecule metabolic process (GO:0043170)	0.83	12	ACTN2, CRYAB, FKTN, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2, DMD, RBM20
striated muscle contraction (GO:0006941)	5.37	12	TPM1, TNNT2, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, SCN5A, DMD, MYBPC3
actin filament-based movement (GO:0030048)	5.54	12	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, MYBPC3, DMD
actin-myosin filament sliding (GO:0033275)	6.09	12	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, DMD, MYBPC3
cellular component assembly (GO:0022607)	2.14	12	ACTN2, PLN, CRYAB, TNNT2, TTN, ACTC1, CSRP3, PSEN1, VCL, MYH6, RAF1, DMD
regulation of blood circulation (GO:1903522)	4.05	12	PLN, TPM1, TNNT2, MYH7, DES, CSRP3, MYH6, TNNI3, DSG2, ABCC9, SCN5A, DMD
positive regulation of biological process (GO:0048518)	1.2	12	ACTN2, TPM1, SCN5A, LMNA, ACTC1, CSRP3, PSEN1, RAF1, PRDM16, PSEN2, DMD, RBM20
actin-mediated cell contraction (GO:0070252)	5.88	12	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, DMD, MYBPC3
cardiac muscle contraction (GO:0060048)	5.88	12	TPM1, TNNT2, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, TTN, SCN5A, MYBPC3, DMD
localization (GO:0051179)	1.4	12	ACTN2, PLN, CSRP3, SCN5A, LMNA, TTN, VCL, ABCC9, PSEN1, RAF1, PSEN2, DMD
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	11	ACTN2, EYA4, MYH6, CSRP3, PSEN1, GATAD1, RAF1, TMPO, PRDM16, DMD, RBM20
regulation of cellular biosynthetic process (GO:0031326)	1.38	11	ACTN2, CSRP3, EYA4, MYH6, GATAD1, PSEN1, FKTN, RAF1, TMPO, PRDM16, DMD
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	11	ACTN2, EYA4, MYH6, CSRP3, PSEN1, GATAD1, RAF1, TMPO, PRDM16, DMD, RBM20
regulation of RNA metabolic process (GO:0051252)	1.52	11	ACTN2, EYA4, MYH6, CSRP3, PSEN1, GATAD1, RAF1, TMPO, PRDM16, DMD, RBM20
regulation of biosynthetic process (GO:0009889)	1.37	11	ACTN2, EYA4, PRDM16, CSRP3, PSEN1, GATAD1, RAF1, TMPO, FKTN, MYH6, DMD
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	11	ACTN2, EYA4, MYH6, CSRP3, PSEN1, GATAD1, FKTN, RAF1, TMPO, PRDM16, DMD
signal transduction (GO:0007165)	1.28	11	ACTN2, PLN, CRYAB, RAF1, PSEN1, ABCC9, MYH6, LMNA, PSEN2, DMD, BAG3
tissue morphogenesis (GO:0048729)	3.87	11	TPM1, TNNT2, MYH6, MYH7, TTN, ACTC1, VCL, TNNI3, TNNC1, PSEN1, MYBPC3
positive regulation of cellular process (GO:0048522)	1.3	11	ACTN2, TPM1, SCN5A, LMNA, CSRP3, PSEN1, RAF1, PRDM16, PSEN2, DMD, RBM20
regulation of hydrolase activity (GO:0051336)	2.53	10	ACTN2, PLN, CRYAB, TNNT2, TNNC1, TPM1, MYH6, TNNI3, RAF1, MYBPC3
cellular protein metabolic process (GO:0044267)	1.63	10	ACTN2, CRYAB, FKTN, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2
regulation of muscle contraction (GO:0006937)	4.75	10	PLN, TPM1, TNNT2, MYH7, TNNC1, DSG2, TNNI3, SCN5A, DMD, MYBPC3
protein metabolic process (GO:0019538)	1.45	10	ACTN2, CRYAB, FKTN, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16, PSEN2
transport (GO:0006810)	1.51	10	ACTN2, PLN, SCN5A, RAF1, TTN, VCL, ABCC9, PSEN1, LMNA, PSEN2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	10	EYA4, PRDM16, CSRP3, PSEN1, GATAD1, RAF1, TMPO, FKTN, MYH6, DMD
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	10	ACTN2, EYA4, MYH6, CSRP3, PSEN1, GATAD1, RAF1, TMPO, PRDM16, DMD
regulation of signaling (GO:0023051)	1.72	10	ACTN2, PLN, FKTN, PSEN1, LMNA, TNNI3, RAF1, PRDM16, ABCC9, DMD
regulation of muscle system process (GO:0090257)	4.51	10	PLN, TPM1, TNNT2, MYH7, TNNC1, DSG2, TNNI3, SCN5A, DMD, MYBPC3
regulation of RNA biosynthetic process (GO:2001141)	1.55	10	ACTN2, EYA4, MYH6, CSRP3, PSEN1, GATAD1, RAF1, TMPO, PRDM16, DMD
response to chemical (GO:0042221)	1.98	10	PLN, CRYAB, TNNT2, TTN, ACTC1, TPM1, DSG2, TNNC1, LMNA, SCN5A
establishment of localization (GO:0051234)	1.48	10	ACTN2, PLN, SCN5A, RAF1, TTN, VCL, ABCC9, PSEN1, LMNA, PSEN2
macromolecular complex subunit organization (GO:0043933)	2.14	9	ACTN2, PLN, CRYAB, TNNT2, RAF1, TTN, EYA4, PRDM16, DMD
cardiac muscle tissue morphogenesis (GO:0055008)	5.8	9	TPM1, TNNT2, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYBPC3
regulation of actin filament-based process (GO:0032970)	3.97	9	ACTN2, PLN, TPM1, TNNT2, TNNC1, CSRP3, DSG2, SCN5A, MYBPC3
cellular nitrogen compound metabolic process (GO:0034641)	1.22	9	EYA4, RAF1, MYH7, PSEN1, MYH6, PRDM16, PSEN2, DMD, RBM20
cellular protein modification process (GO:0006464)	1.79	9	ACTN2, CRYAB, FKTN, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16
regulation of transcription, DNA-templated (GO:0006355)	1.56	9	EYA4, MYH6, CSRP3, PSEN1, GATAD1, RAF1, TMPO, PRDM16, DMD
macromolecule modification (GO:0043412)	1.73	9	ACTN2, CRYAB, FKTN, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16
nitrogen compound metabolic process (GO:0006807)	1.13	9	EYA4, RAF1, MYH7, PSEN1, MYH6, PRDM16, PSEN2, DMD, RBM20
protein modification process (GO:0036211)	1.79	9	ACTN2, CRYAB, FKTN, TTN, EYA4, PSEN1, RAF1, MYH6, PRDM16
muscle tissue morphogenesis (GO:0060415)	5.62	9	TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYBPC3
response to abiotic stimulus (GO:0009628)	2.8	8	CRYAB, LMNA, TTN, CSRP3, RAF1, PSEN2, DMD, BAG3
single-organism metabolic process (GO:0044710)	1.63	8	ACTN2, CRYAB, RAF1, MYH7, PSEN1, MYH6, FKTN, SDHA
regulation of cell death (GO:0010941)	2.43	8	ACTN2, CRYAB, RAF1, ACTC1, PSEN1, LMNA, PSEN2, BAG3
actomyosin structure organization (GO:0031032)	5.4	8	ACTN2, TPM1, TTN, ACTC1, CSRP3, MYPN, MYH6, LDB3
regulation of cellular localization (GO:0060341)	3.03	8	ACTN2, PLN, CRYAB, TNNT2, TNNC1, LMNA, DMD, MYBPC3
regulation of developmental process (GO:0050793)	2.1	8	TPM1, LMNA, LAMA4, CSRP3, MYH6, PSEN1, PRDM16, DMD
regulation of transport (GO:0051049)	2.24	8	ACTN2, PLN, CRYAB, TNNT2, TNNC1, SCN5A, DMD, MYBPC3
cell development (GO:0048468)	3.28	8	ACTN2, SGCD, TTN, PSEN1, MYH6, LMNA, DMD, NEXN
regulation of programmed cell death (GO:0043067)	2.49	8	ACTN2, CRYAB, RAF1, ACTC1, PSEN1, LMNA, PSEN2, BAG3
actin cytoskeleton organization (GO:0030036)	4.1	8	ACTN2, TPM1, TTN, ACTC1, CSRP3, MYPN, MYH6, LDB3
regulation of cellular component organization (GO:0051128)	2.01	8	ACTN2, CRYAB, RAF1, TPM1, PSEN1, LMNA, DMD, NEXN
regulation of signal transduction (GO:0009966)	1.84	8	ACTN2, PLN, PRDM16, PSEN1, LMNA, RAF1, FKTN, DMD
response to stress (GO:0006950)	1.8	8	CRYAB, RAF1, TPM1, PSEN1, ABCC9, LMNA, PSEN2, EYA4
positive regulation of molecular function (GO:0044093)	2.23	8	ACTN2, TPM1, TNNT2, PSEN1, RAF1, PSEN2, DMD, MYBPC3
regulation of cell communication (GO:0010646)	1.73	8	ACTN2, PLN, PRDM16, PSEN1, LMNA, RAF1, FKTN, DMD
regulation of apoptotic process (GO:0042981)	2.5	8	ACTN2, CRYAB, RAF1, ACTC1, PSEN1, LMNA, PSEN2, BAG3
muscle cell development (GO:0055001)	5.29	7	ACTN2, SGCD, TTN, MYH6, LMNA, DMD, NEXN
cellular response to stimulus (GO:0051716)	1.97	7	CRYAB, SCN5A, EYA4, PSEN1, TPM1, LMNA, BAG3
regulation of ATPase activity (GO:0043462)	5.59	7	PLN, TPM1, TNNT2, TNNC1, MYH6, TNNI3, MYBPC3
protein complex subunit organization (GO:0071822)	2.6	7	ACTN2, PLN, CRYAB, TNNT2, TTN, RAF1, DMD
response to external stimulus (GO:0009605)	2.55	7	CSRP3, LMNA, TTN, RAF1, ABCC9, DMD, BAG3
ventricular cardiac muscle tissue morphogenesis (GO:0055010)	6.07	7	TPM1, TNNT2, MYH7, TNNC1, MYH6, TNNI3, MYBPC3
negative regulation of cell death (GO:0060548)	2.95	7	CRYAB, RAF1, ACTC1, PSEN1, LMNA, PSEN2, BAG3
protein complex assembly (GO:0006461)	2.78	7	ACTN2, PLN, CRYAB, TNNT2, TTN, RAF1, DMD
muscle organ development (GO:0007517)	4.98	7	CSRP3, LMNA, CRYAB, MYH6, SGCD, FKTN, DMD
macromolecular complex assembly (GO:0065003)	2.55	7	ACTN2, PLN, CRYAB, TNNT2, TTN, RAF1, DMD
regulation of heart rate (GO:0002027)	5.29	7	PLN, TPM1, SCN5A, MYH7, DSG2, MYH6, DMD
phosphate-containing compound metabolic process (GO:0006796)	2.16	7	ACTN2, CRYAB, MYH7, TTN, EYA4, MYH6, RAF1
negative regulation of apoptotic process (GO:0043066)	3.04	7	CRYAB, RAF1, ACTC1, PSEN1, LMNA, PSEN2, BAG3
negative regulation of molecular function (GO:0044092)	2.74	7	ACTN2, PLN, CRYAB, TNNT2, PSEN1, TNNI3, RAF1
phosphorus metabolic process (GO:0006793)	2.15	7	ACTN2, CRYAB, MYH7, TTN, EYA4, MYH6, RAF1
muscle structure development (GO:0061061)	4.96	7	CSRP3, LMNA, CRYAB, MYH6, SGCD, FKTN, DMD
intracellular signal transduction (GO:0035556)	2.39	7	ACTN2, PLN, CRYAB, PSEN1, RAF1, PSEN2, DMD
negative regulation of programmed cell death (GO:0043069)	3.02	7	CRYAB, RAF1, ACTC1, PSEN1, LMNA, PSEN2, BAG3
positive regulation of catalytic activity (GO:0043085)	2.4	7	ACTN2, TPM1, TNNT2, PSEN1, RAF1, PSEN2, MYBPC3
regulation of membrane potential (GO:0042391)	3.89	6	ACTN2, PLN, SCN5A, DSG2, PSEN1, DMD
protein localization (GO:0008104)	2.36	6	CSRP3, LMNA, VCL, PSEN1, RAF1, DMD
negative regulation of metabolic process (GO:0009892)	1.93	6	CRYAB, PRDM16, RAF1, PSEN1, FKTN, DMD
positive regulation of metabolic process (GO:0009893)	1.74	6	CSRP3, PRDM16, ACTC1, PSEN1, RAF1, RBM20
negative regulation of response to stimulus (GO:0048585)	2.52	6	PRDM16, RAF1, PSEN1, LMNA, FKTN, DMD
cell differentiation (GO:0030154)	2.14	6	CSRP3, PRDM16, LAMA4, PSEN1, TNNI3, RAF1
homeostatic process (GO:0042592)	2.61	6	PLN, CSRP3, PSEN1, TNNI3, RAF1, DMD
negative regulation of signaling (GO:0023057)	2.65	6	PRDM16, RAF1, PSEN1, LMNA, FKTN, DMD
regulation of striated muscle contraction (GO:0006942)	5.38	6	PLN, SCN5A, MYH7, DSG2, DMD, MYBPC3
negative regulation of cell communication (GO:0010648)	2.66	6	PRDM16, RAF1, PSEN1, LMNA, FKTN, DMD
cell surface receptor signaling pathway (GO:0007166)	2.09	6	PLN, PSEN1, MYH6, RAF1, PSEN2, BAG3
negative regulation of catalytic activity (GO:0043086)	3.0	6	PLN, CRYAB, TNNT2, PSEN1, TNNI3, RAF1
organic cyclic compound metabolic process (GO:1901360)	1.26	6	EYA4, PRDM16, MYH7, MYH6, RAF1, RBM20
nucleobase-containing compound metabolic process (GO:0006139)	1.35	6	EYA4, PRDM16, MYH7, MYH6, RAF1, RBM20
organelle assembly (GO:0070925)	3.75	6	CSRP3, TTN, ACTC1, MYH6, PSEN1, DMD
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	6	CRYAB, PRDM16, RAF1, PSEN1, FKTN, DMD
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	6	CSRP3, PRDM16, ACTC1, PSEN1, RAF1, RBM20
negative regulation of signal transduction (GO:0009968)	2.75	6	PRDM16, RAF1, PSEN1, LMNA, FKTN, DMD
regulation of protein metabolic process (GO:0051246)	1.93	6	CRYAB, RAF1, TTN, PSEN1, FKTN, DMD
response to mechanical stimulus (GO:0009612)	4.41	6	CSRP3, LMNA, TTN, RAF1, DMD, BAG3
regulation of cell motility (GO:2000145)	3.16	6	TPM1, LMNA, LAMA4, VCL, RAF1, NEXN
macromolecule localization (GO:0033036)	2.34	6	CSRP3, LMNA, VCL, PSEN1, RAF1, DMD
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	6	CSRP3, TTN, ACTC1, MYH6, PSEN1, DMD
cellular homeostasis (GO:0019725)	3.23	6	PLN, CSRP3, PSEN1, TNNI3, RAF1, DMD
striated muscle cell development (GO:0055002)	5.42	6	ACTN2, TTN, MYH6, LMNA, DMD, NEXN
negative regulation of cellular metabolic process (GO:0031324)	2.01	6	CRYAB, PRDM16, RAF1, PSEN1, FKTN, DMD
regulation of actin filament-based movement (GO:1903115)	6.33	6	PLN, SCN5A, TNNC1, DSG2, TNNT2, MYBPC3
ion transport (GO:0006811)	2.66	6	PLN, SCN5A, PSEN1, ABCC9, RAF1, PSEN2
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	EYA4, PRDM16, MYH7, MYH6, RAF1, RBM20
single-organism transport (GO:0044765)	2.18	6	ACTN2, LMNA, TTN, VCL, RAF1, ABCC9
regulation of cellular protein metabolic process (GO:0032268)	1.99	6	CRYAB, RAF1, TTN, PSEN1, FKTN, DMD
sarcomere organization (GO:0045214)	6.4	6	ACTN2, TPM1, TTN, MYPN, MYH6, LDB3
cell adhesion (GO:0007155)	2.82	6	ACTN2, LAMA4, PSEN1, DSG2, VCL, MYBPC3
response to inorganic substance (GO:0010035)	3.56	6	PLN, CRYAB, SCN5A, TTN, TNNC1, TNNT2
single-organism localization (GO:1902578)	2.09	6	ACTN2, LMNA, TTN, VCL, RAF1, ABCC9
heterocycle metabolic process (GO:0046483)	1.31	6	EYA4, PRDM16, MYH7, MYH6, RAF1, RBM20
heart development (GO:0007507)	4.24	6	MYH7, PSEN1, TNNI3, MYH6, RAF1, RBM20
regulation of locomotion (GO:0040012)	3.12	6	TPM1, LMNA, LAMA4, VCL, RAF1, NEXN
biological adhesion (GO:0022610)	2.81	6	ACTN2, LAMA4, PSEN1, DSG2, VCL, MYBPC3
regulation of cell differentiation (GO:0045595)	2.42	6	CSRP3, PRDM16, PSEN1, LMNA, RAF1, DMD
positive regulation of gene expression (GO:0010628)	2.35	6	CSRP3, PRDM16, ACTC1, PSEN1, RAF1, RBM20
regulation of multicellular organismal development (GO:2000026)	2.31	6	PRDM16, LAMA4, PSEN1, MYH6, LMNA, DMD
cardiac muscle cell development (GO:0055013)	6.4	5	ACTN2, TTN, NEXN, MYH6, LMNA
regulation of intracellular transport (GO:0032386)	3.58	5	PLN, TNNC1, CRYAB, TNNT2, MYBPC3
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	5	TTN, CSRP3, ACTC1, DMD, MYH6
striated muscle tissue development (GO:0014706)	5.23	5	PLN, CSRP3, DMD, SGCD, DSG2
regulation of phosphate metabolic process (GO:0019220)	2.35	5	TTN, FKTN, DMD, RAF1, PSEN1
cell death (GO:0008219)	3.05	5	CRYAB, ACTC1, RAF1, PSEN1, BAG3
negative regulation of protein metabolic process (GO:0051248)	2.82	5	FKTN, DMD, RAF1, CRYAB, PSEN1
negative regulation of hydrolase activity (GO:0051346)	3.74	5	PLN, TNNI3, CRYAB, TNNT2, RAF1
positive regulation of multicellular organismal process (GO:0051240)	2.49	5	DMD, SCN5A, LMNA, PSEN1, TPM1
regulation of protein modification process (GO:0031399)	2.32	5	TTN, FKTN, DMD, PSEN1, RAF1
positive regulation of cellular metabolic process (GO:0031325)	1.81	5	RBM20, CSRP3, RAF1, PSEN1, PRDM16
response to oxygen-containing compound (GO:1901700)	2.57	5	PLN, CRYAB, ACTC1, TPM1, DSG2
regulation of cell migration (GO:0030334)	3.23	5	LAMA4, NEXN, VCL, LMNA, TPM1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	5	RBM20, CSRP3, PSEN1, RAF1, PRDM16
cardiac cell development (GO:0055006)	6.33	5	ACTN2, TTN, NEXN, MYH6, LMNA
cation transport (GO:0006812)	3.11	5	PSEN2, ABCC9, SCN5A, PSEN1, PLN
apoptotic process (GO:0006915)	3.14	5	ACTC1, CRYAB, PSEN1, RAF1, BAG3
tissue development (GO:0009888)	3.27	5	PLN, CSRP3, DMD, SGCD, DSG2
regulation of phosphorus metabolic process (GO:0051174)	2.35	5	TTN, FKTN, DMD, PSEN1, RAF1
programmed cell death (GO:0012501)	3.1	5	CRYAB, RAF1, ACTC1, PSEN1, BAG3
metal ion transport (GO:0030001)	3.36	5	PLN, ABCC9, SCN5A, PSEN1, PSEN2
response to metal ion (GO:0010038)	3.91	5	PLN, TNNT2, SCN5A, TTN, TNNC1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	5	RBM20, CSRP3, RAF1, PSEN1, PRDM16
cellular chemical homeostasis (GO:0055082)	3.4	5	PLN, TNNI3, CSRP3, RAF1, PSEN1
regulation of intracellular signal transduction (GO:1902531)	2.31	5	PLN, FKTN, DMD, RAF1, PSEN1
regulation of phosphorylation (GO:0042325)	2.5	5	TTN, FKTN, DMD, RAF1, PSEN1
positive regulation of cell differentiation (GO:0045597)	3.01	5	CSRP3, DMD, PSEN1, LMNA, PRDM16
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	5	FKTN, CRYAB, RAF1, DMD, PSEN1
organonitrogen compound metabolic process (GO:1901564)	2.32	5	PSEN2, DMD, MYH7, PSEN1, MYH6
positive regulation of RNA metabolic process (GO:0051254)	2.51	5	RBM20, CSRP3, PSEN1, RAF1, PRDM16
chemical homeostasis (GO:0048878)	2.97	5	PLN, TNNI3, CSRP3, RAF1, PSEN1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	5	CSRP3, PSEN1, RAF1, PRDM16, MYH6
cellular response to stress (GO:0033554)	2.51	5	TPM1, EYA4, CRYAB, PSEN1, LMNA
muscle tissue development (GO:0060537)	5.1	5	PLN, CSRP3, DMD, SGCD, DSG2
regulation of protein phosphorylation (GO:0001932)	2.57	5	TTN, FKTN, DMD, PSEN1, RAF1
positive regulation of cellular component organization (GO:0051130)	2.68	4	ACTN2, DMD, TPM1, PSEN1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	4	CSRP3, PSEN1, RAF1, PRDM16
negative regulation of multicellular organismal process (GO:0051241)	2.84	4	PLN, PSEN1, LMNA, PRDM16
regulation of organelle organization (GO:0033043)	2.72	4	ACTN2, TPM1, NEXN, LMNA
cell projection organization (GO:0030030)	3.14	4	ACTN2, DMD, TPM1, VCL
phosphorylation (GO:0016310)	2.63	4	ACTN2, TTN, CRYAB, RAF1
ion homeostasis (GO:0050801)	3.42	4	PLN, TNNI3, CSRP3, PSEN1
nucleic acid metabolic process (GO:0090304)	1.46	4	RBM20, EYA4, RAF1, PRDM16
secretion by cell (GO:0032940)	3.59	4	ACTN2, TTN, RAF1, VCL
circulatory system process (GO:0003013)	4.38	4	TNNI3, PLN, SGCD, ACTC1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	4	CSRP3, RAF1, PSEN1, PRDM16
calcium ion homeostasis (GO:0055074)	3.97	4	PLN, TNNI3, CSRP3, PSEN1
inorganic ion homeostasis (GO:0098771)	3.43	4	PLN, TNNI3, CSRP3, PSEN1
regulation of ion transmembrane transport (GO:0034765)	3.77	4	PLN, ACTN2, DMD, SCN5A
response to hypoxia (GO:0001666)	4.13	4	PSEN2, CRYAB, LMNA, RAF1
multicellular organism development (GO:0007275)	2.54	4	EYA4, CSRP3, MYH6, TPM1
regulation of transmembrane transport (GO:0034762)	3.74	4	ACTN2, PLN, DMD, SCN5A
regulation of MAPK cascade (GO:0043408)	3.22	4	FKTN, DMD, RAF1, PSEN1
response to muscle stretch (GO:0035994)	6.78	4	TTN, DMD, CSRP3, RAF1
divalent inorganic cation homeostasis (GO:0072507)	3.9	4	PLN, TNNI3, CSRP3, PSEN1
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	4	PLN, TNNI3, CSRP3, PSEN1
positive regulation of hydrolase activity (GO:0051345)	2.91	4	ACTN2, MYBPC3, TNNT2, TPM1
cellular macromolecule localization (GO:0070727)	3.1	4	CSRP3, DMD, VCL, LMNA
positive regulation of biosynthetic process (GO:0009891)	2.29	4	CSRP3, PSEN1, RAF1, PRDM16
regulation of cardiac muscle contraction (GO:0055117)	5.57	4	PLN, DMD, SCN5A, DSG2
regulation of the force of heart contraction (GO:0002026)	6.4	4	PLN, CSRP3, MYH7, MYH6
negative regulation of developmental process (GO:0051093)	3.17	4	CSRP3, PSEN1, LMNA, PRDM16
regulation of ion transport (GO:0043269)	3.4	4	ACTN2, PLN, DMD, SCN5A
cellular localization (GO:0051641)	2.32	4	CSRP3, DMD, VCL, LMNA
regulation of receptor activity (GO:0010469)	4.98	4	ACTN2, PLN, DMD, PSEN1
regulation of cell proliferation (GO:0042127)	2.41	4	TPM1, SCN5A, FKTN, RAF1
cardiac muscle tissue development (GO:0048738)	6.33	4	PLN, CSRP3, SGCD, DSG2
protein phosphorylation (GO:0006468)	2.89	4	TTN, ACTN2, CRYAB, RAF1
myofibril assembly (GO:0030239)	6.43	4	TTN, CSRP3, ACTC1, MYH6
cellular metal ion homeostasis (GO:0006875)	3.75	4	PLN, TNNI3, CSRP3, PSEN1
cellular calcium ion homeostasis (GO:0006874)	4.01	4	PLN, TNNI3, CSRP3, PSEN1
cellular protein localization (GO:0034613)	3.11	4	CSRP3, DMD, LMNA, VCL
cellular ion homeostasis (GO:0006873)	3.57	4	PLN, TNNI3, CSRP3, PSEN1
regulation of metal ion transport (GO:0010959)	3.94	4	PLN, ACTN2, DMD, SCN5A
ion transmembrane transport (GO:0034220)	3.08	4	ABCC9, SCN5A, RAF1, PSEN1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	4	CSRP3, PSEN1, RAF1, PRDM16
cellular cation homeostasis (GO:0030003)	3.6	4	PLN, TNNI3, CSRP3, PSEN1
metal ion homeostasis (GO:0055065)	3.61	4	PLN, TNNI3, CSRP3, PSEN1
cation homeostasis (GO:0055080)	3.46	4	PLN, TNNI3, CSRP3, PSEN1
response to organic substance (GO:0010033)	2.2	4	PLN, CRYAB, ACTC1, DSG2
response to oxygen levels (GO:0070482)	4.02	4	PSEN2, CRYAB, RAF1, LMNA
protein oligomerization (GO:0051259)	3.71	4	PLN, ACTN2, CRYAB, TNNT2
establishment of protein localization (GO:0045184)	2.53	4	ACTN2, PSEN1, RAF1, LMNA
secretion (GO:0046903)	3.38	4	TTN, ACTN2, VCL, RAF1
transmembrane transport (GO:0055085)	2.72	4	ABCC9, SCN5A, RAF1, PSEN1
positive regulation of developmental process (GO:0051094)	2.77	4	CSRP3, PSEN1, DMD, LMNA
muscle fiber development (GO:0048747)	5.8	4	TTN, DMD, NEXN, MYH6
response to decreased oxygen levels (GO:0036293)	4.09	4	PSEN2, CRYAB, RAF1, LMNA
regulation of response to stress (GO:0080134)	2.53	4	FKTN, CRYAB, RAF1, BAG3
regulation of cation transmembrane transport (GO:1904062)	4.4	4	ACTN2, PLN, DMD, SCN5A
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	4	CSRP3, PSEN1, RAF1, PRDM16
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	4	CSRP3, RAF1, PSEN1, PRDM16
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	3	RAF1, PSEN1, LMNA
regulation of kinase activity (GO:0043549)	3.07	3	TTN, RAF1, PSEN1
single organismal cell-cell adhesion (GO:0016337)	3.69	3	VCL, PSEN1, DSG2
positive regulation of transport (GO:0051050)	2.9	3	ACTN2, DMD, SCN5A
regulation of cardiac conduction (GO:1903779)	5.57	3	PLN, ABCC9, TNNI3
regulation of apoptotic signaling pathway (GO:2001233)	3.83	3	RAF1, PSEN1, LMNA
regulation of cytoskeleton organization (GO:0051493)	3.72	3	ACTN2, TPM1, NEXN
regulation of cell adhesion (GO:0030155)	3.27	3	DMD, LAMA4, TPM1
cell junction organization (GO:0034330)	4.51	3	ACTN2, VCL, DSG2
negative regulation of proteolysis (GO:0045861)	3.98	3	CRYAB, PSEN1, RAF1
negative regulation of cellular component organization (GO:0051129)	3.35	3	RAF1, PSEN1, LMNA
regulation of homeostatic process (GO:0032844)	3.65	3	PLN, DMD, SCN5A
cellular biosynthetic process (GO:0044249)	1.37	3	EYA4, DMD, PRDM16
negative regulation of gene expression (GO:0010629)	2.48	3	CRYAB, PSEN1, PRDM16
single organism cell adhesion (GO:0098602)	3.63	3	VCL, PSEN1, DSG2
cellular macromolecular complex assembly (GO:0034622)	3.18	3	TTN, DMD, CRYAB
small molecule metabolic process (GO:0044281)	2.38	3	MYH7, MYH6, SDHA
cellular response to chemical stimulus (GO:0070887)	2.57	3	TPM1, SCN5A, LMNA
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	3	PSEN2, RAF1, MYH6
response to calcium ion (GO:0051592)	4.98	3	TTN, SCN5A, TNNT2
response to organic cyclic compound (GO:0014070)	3.07	3	PLN, CRYAB, DSG2
regulation of cardiac muscle cell contraction (GO:0086004)	6.51	3	PLN, SCN5A, DSG2
organic substance biosynthetic process (GO:1901576)	1.34	3	EYA4, DMD, PRDM16
Notch signaling pathway (GO:0007219)	4.99	3	PLN, PSEN2, PSEN1
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	3	ACTN2, PLN, DMD
cardiac conduction (GO:0061337)	5.54	3	PLN, SCN5A, DSG2
response to lipid (GO:0033993)	3.11	3	PLN, CRYAB, DSG2
platelet degranulation (GO:0002576)	5.12	3	ACTN2, TTN, VCL
exocytosis (GO:0006887)	4.11	3	ACTN2, TTN, VCL
MAPK cascade (GO:0000165)	3.91	3	ACTN2, CRYAB, RAF1
regulated exocytosis (GO:0045055)	4.44	3	ACTN2, TTN, VCL
negative regulation of ATPase activity (GO:0032780)	7.16	3	PLN, TNNI3, TNNT2
regulation of transporter activity (GO:0032409)	4.45	3	PLN, ACTN2, DMD
regulation of immune system process (GO:0002682)	2.5	3	RAF1, PSEN1, PRDM16
signal transduction by protein phosphorylation (GO:0023014)	3.79	3	ACTN2, CRYAB, RAF1
cell projection assembly (GO:0030031)	4.19	3	ACTN2, DMD, VCL
actin filament organization (GO:0007015)	4.54	3	TTN, TNNT2, ACTC1
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	3	EYA4, DMD, PRDM16
inorganic cation transmembrane transport (GO:0098662)	3.55	3	ABCC9, SCN5A, PSEN1
negative regulation of cell proliferation (GO:0008285)	3.26	3	TPM1, FKTN, RAF1
organ morphogenesis (GO:0009887)	3.55	3	MYBPC3, SCN5A, PSEN1
cardiac myofibril assembly (GO:0055003)	7.02	3	TTN, CSRP3, ACTC1
negative regulation of protein phosphorylation (GO:0001933)	3.79	3	DMD, FKTN, PSEN1
negative regulation of transport (GO:0051051)	3.6	3	ACTN2, PLN, CRYAB
negative regulation of phosphate metabolic process (GO:0045936)	3.45	3	DMD, FKTN, PSEN1
cell-cell adhesion (GO:0098609)	3.34	3	VCL, PSEN1, DSG2
neurological system process (GO:0050877)	2.64	3	TNNI3, EYA4, PSEN1
regulation of muscle filament sliding (GO:0032971)	8.34	3	TNNC1, MYBPC3, TNNT2
regulation of protein kinase activity (GO:0045859)	3.15	3	TTN, RAF1, PSEN1
calcium ion transport (GO:0006816)	4.33	3	PSEN2, PLN, PSEN1
protein homooligomerization (GO:0051260)	4.21	3	PLN, ACTN2, CRYAB
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	3	DMD, FKTN, PSEN1
positive regulation of ion transport (GO:0043270)	4.36	3	ACTN2, DMD, SCN5A
negative regulation of cell differentiation (GO:0045596)	3.33	3	CSRP3, PSEN1, PRDM16
biosynthetic process (GO:0009058)	1.32	3	EYA4, DMD, PRDM16
regulation of proteolysis (GO:0030162)	3.2	3	CRYAB, PSEN1, RAF1
organic substance transport (GO:0071702)	2.15	3	PSEN1, RAF1, LMNA
cell-cell junction organization (GO:0045216)	4.66	3	ACTN2, VCL, DSG2
regulation of cation channel activity (GO:2001257)	5.27	3	ACTN2, PLN, DMD
divalent metal ion transport (GO:0070838)	4.15	3	PLN, PSEN2, PSEN1
cellular protein complex assembly (GO:0043623)	3.9	3	TTN, CRYAB, DMD
response to oxidative stress (GO:0006979)	3.9	3	CRYAB, TPM1, PSEN1
skeletal muscle contraction (GO:0003009)	6.33	3	TNNI3, TNNC1, MYH7
RNA metabolic process (GO:0016070)	1.59	3	EYA4, RBM20, PRDM16
single organism signaling (GO:0044700)	3.25	3	PLN, SCN5A, DSG2
negative regulation of phosphorylation (GO:0042326)	3.7	3	DMD, FKTN, PSEN1
divalent inorganic cation transport (GO:0072511)	4.13	3	PSEN2, PLN, PSEN1
vesicle-mediated transport (GO:0016192)	2.72	3	ACTN2, TTN, VCL
cellular amide metabolic process (GO:0043603)	3.23	3	PSEN2, DMD, PSEN1
heart contraction (GO:0060047)	7.02	3	TNNI3, SGCD, ACTC1
regulation of transmembrane transporter activity (GO:0022898)	4.52	3	ACTN2, PLN, DMD
negative regulation of protein modification process (GO:0031400)	3.4	3	DMD, FKTN, PSEN1
regulation of cellular response to stress (GO:0080135)	3.4	3	CRYAB, FKTN, BAG3
inorganic ion transmembrane transport (GO:0098660)	3.38	3	ABCC9, SCN5A, PSEN1
regulation of transferase activity (GO:0051338)	2.88	3	TTN, RAF1, PSEN1
immune system process (GO:0002376)	2.29	3	ABCC9, RAF1, PSEN1
cardiac muscle fiber development (GO:0048739)	7.65	3	TTN, NEXN, MYH6
multicellular organismal signaling (GO:0035637)	5.36	3	PLN, SCN5A, DSG2
regulation of ion homeostasis (GO:2000021)	4.44	3	PLN, DMD, SCN5A
positive regulation of ATPase activity (GO:0032781)	5.99	3	MYBPC3, TNNT2, TPM1
protein transport (GO:0015031)	2.62	3	RAF1, PSEN1, LMNA
signaling (GO:0023052)	3.25	3	PLN, SCN5A, DSG2
peptide metabolic process (GO:0006518)	3.44	3	PSEN2, DMD, PSEN1
cation transmembrane transport (GO:0098655)	3.43	3	ABCC9, SCN5A, PSEN1
heart process (GO:0003015)	7.02	3	TNNI3, SGCD, ACTC1
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	RAF1, LMNA
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	5.13	2	RAF1, LMNA
detection of external stimulus (GO:0009581)	4.98	2	TTN, CSRP3
protein dephosphorylation (GO:0006470)	4.47	2	EYA4, MYH6
negative regulation of intracellular transport (GO:0032387)	5.02	2	PLN, CRYAB
regulation of sequestering of calcium ion (GO:0051282)	5.07	2	PLN, DMD
activation of protein kinase activity (GO:0032147)	4.08	2	RAF1, PSEN1
regulation of calcium-mediated signaling (GO:0050848)	5.41	2	PLN, DMD
purine ribonucleoside monophosphate metabolic process (GO:0009167)	4.7	2	MYH7, MYH6
anion transport (GO:0006820)	3.71	2	ABCC9, PSEN1
ribonucleoside monophosphate metabolic process (GO:0009161)	4.62	2	MYH7, MYH6
action potential (GO:0001508)	5.42	2	DMD, SCN5A
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	2	PSEN2, RAF1
negative regulation of ion transmembrane transport (GO:0034766)	5.47	2	ACTN2, PLN
positive regulation of ion transmembrane transport (GO:0034767)	5.05	2	ACTN2, DMD
organic cyclic compound biosynthetic process (GO:1901362)	1.66	2	EYA4, PRDM16
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)	3.79	2	MYH6, PSEN1
positive regulation of cell projection organization (GO:0031346)	3.99	2	DMD, PSEN1
nitrogen compound transport (GO:0071705)	3.54	2	RAF1, PSEN1
positive regulation of cell adhesion (GO:0045785)	3.79	2	DMD, TPM1
positive regulation of signal transduction (GO:0009967)	2.5	2	RAF1, PSEN1
positive regulation of cytoskeleton organization (GO:0051495)	4.58	2	ACTN2, TPM1
skeletal muscle tissue development (GO:0007519)	5.65	2	CSRP3, DMD
response to wounding (GO:0009611)	4.39	2	TPM1, RAF1
peptidyl-amino acid modification (GO:0018193)	2.98	2	TTN, PRDM16
regulation of calcium ion import (GO:0090279)	5.08	2	PLN, DMD
regulation of neuron differentiation (GO:0045664)	3.39	2	DMD, PSEN1
ribonucleoside triphosphate metabolic process (GO:0009199)	4.77	2	MYH7, MYH6
positive regulation of neuron differentiation (GO:0045666)	3.98	2	DMD, PSEN1
positive regulation of cell development (GO:0010720)	3.57	2	DMD, PSEN1
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	2	CRYAB, RAF1
regulation of calcium ion transport into cytosol (GO:0010522)	5.23	2	PLN, DMD
regulation of sodium ion transmembrane transport (GO:1902305)	5.86	2	DMD, SCN5A
purine ribonucleoside triphosphate metabolic process (GO:0009205)	4.81	2	MYH7, MYH6
positive regulation of response to stimulus (GO:0048584)	2.18	2	RAF1, PSEN1
calcium-mediated signaling (GO:0019722)	5.24	2	PLN, DMD
ATP metabolic process (GO:0046034)	4.98	2	MYH7, MYH6
regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	6.51	2	PLN, DMD
single organism reproductive process (GO:0044702)	2.73	2	LMNA, DSG2
positive regulation of neuron projection development (GO:0010976)	4.26	2	DMD, PSEN1
regulation of neuron projection development (GO:0010975)	3.69	2	DMD, PSEN1
purine ribonucleoside metabolic process (GO:0046128)	4.33	2	MYH7, MYH6
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	PSEN1, PRDM16
stem cell population maintenance (GO:0019827)	4.83	2	RAF1, PRDM16
positive regulation of phosphorylation (GO:0042327)	2.9	2	RAF1, PSEN1
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	2	RAF1, PSEN1
membrane organization (GO:0061024)	3.04	2	SGCD, LMNA
intermediate filament cytoskeleton organization (GO:0045104)	6.04	2	DES, RAF1
Wnt signaling pathway (GO:0016055)	3.88	2	MYH6, PSEN1
positive regulation of organelle organization (GO:0010638)	3.38	2	ACTN2, TPM1
intermediate filament-based process (GO:0045103)	6.02	2	DES, RAF1
purine nucleotide metabolic process (GO:0006163)	4.09	2	MYH7, MYH6
detection of mechanical stimulus (GO:0050982)	5.94	2	TTN, CSRP3
positive regulation of heart contraction (GO:0045823)	6.15	2	TPM1, SCN5A
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	6.68	2	PLN, DMD
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881)	6.9	2	PLN, DMD
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.59	2	PLN, DMD
organophosphate metabolic process (GO:0019637)	3.04	2	MYH7, MYH6
aromatic compound biosynthetic process (GO:0019438)	1.7	2	EYA4, PRDM16
positive regulation of cation transmembrane transport (GO:1904064)	5.17	2	ACTN2, DMD
morphogenesis of an epithelium (GO:0002009)	4.08	2	VCL, PSEN1
positive regulation of ion transmembrane transporter activity (GO:0032414)	5.55	2	ACTN2, DMD
negative regulation of transporter activity (GO:0032410)	5.59	2	PLN, ACTN2
regulation of skeletal muscle contraction (GO:0014819)	7.33	2	DMD, MYH7
negative regulation of biosynthetic process (GO:0009890)	2.47	2	PSEN1, PRDM16
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	TPM1, PSEN1
nucleoside triphosphate metabolic process (GO:0009141)	4.61	2	MYH7, MYH6
purine nucleoside triphosphate metabolic process (GO:0009144)	4.76	2	MYH7, MYH6
response to reactive oxygen species (GO:0000302)	4.5	2	CRYAB, TPM1
negative regulation of cellular component movement (GO:0051271)	4.22	2	TPM1, VCL
microtubule cytoskeleton organization (GO:0000226)	4.13	2	CRYAB, LMNA
second-messenger-mediated signaling (GO:0019932)	4.65	2	PLN, DMD
amyloid precursor protein catabolic process (GO:0042987)	7.65	2	PSEN2, PSEN1
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	RAF1, PSEN1
nucleic acid-templated transcription (GO:0097659)	1.91	2	EYA4, PRDM16
amyloid precursor protein metabolic process (GO:0042982)	7.24	2	PSEN2, PSEN1
detection of muscle stretch (GO:0035995)	8.34	2	TTN, CSRP3
positive regulation of transferase activity (GO:0051347)	3.31	2	RAF1, PSEN1
immune response-regulating signaling pathway (GO:0002764)	3.72	2	RAF1, PSEN1
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	RAF1, PSEN1
blood vessel development (GO:0001568)	4.95	2	LAMA4, PSEN1
regulation of cell projection organization (GO:0031344)	3.38	2	DMD, PSEN1
positive regulation of immune system process (GO:0002684)	2.96	2	RAF1, PSEN1
homotypic cell-cell adhesion (GO:0034109)	5.76	2	VCL, DSG2
negative regulation of intracellular signal transduction (GO:1902532)	3.63	2	DMD, FKTN
cellular response to abiotic stimulus (GO:0071214)	4.15	2	CRYAB, BAG3
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	ACTN2, PLN
heterocycle biosynthetic process (GO:0018130)	1.7	2	EYA4, PRDM16
regulation of cellular component biogenesis (GO:0044087)	3.08	2	TPM1, RAF1
positive regulation of transmembrane transport (GO:0034764)	4.99	2	ACTN2, DMD
wound healing (GO:0042060)	5.13	2	TPM1, RAF1
purine ribonucleotide metabolic process (GO:0009150)	4.16	2	MYH7, MYH6
positive regulation of MAPK cascade (GO:0043410)	3.57	2	RAF1, PSEN1
canonical Wnt signaling pathway (GO:0060070)	5.26	2	MYH6, PSEN1
positive regulation of blood circulation (GO:1903524)	5.16	2	TPM1, SCN5A
macromolecule glycosylation (GO:0043413)	4.2	2	FKTN, PSEN1
regulation of actin cytoskeleton organization (GO:0032956)	4.09	2	ACTN2, TPM1
somatic stem cell population maintenance (GO:0035019)	5.52	2	RAF1, PRDM16
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	RAF1, PSEN1
positive regulation of nervous system development (GO:0051962)	3.64	2	DMD, PSEN1
negative regulation of peptidase activity (GO:0010466)	4.22	2	CRYAB, RAF1
Notch receptor processing (GO:0007220)	6.9	2	PSEN2, PSEN1
detection of stimulus (GO:0051606)	3.22	2	TTN, CSRP3
brain development (GO:0007420)	4.24	2	PSEN1, BAG3
sensory organ development (GO:0007423)	4.82	2	CRYAB, PRDM16
maintenance of cell number (GO:0098727)	4.82	2	RAF1, PRDM16
positive regulation of protein modification process (GO:0031401)	2.7	2	RAF1, PSEN1
cell activation (GO:0001775)	3.47	2	RAF1, PSEN1
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154)	5.29	2	CRYAB, RAF1
muscle hypertrophy (GO:0014896)	6.68	2	TTN, CSRP3
striated muscle hypertrophy (GO:0014897)	6.78	2	TTN, CSRP3
transcription, DNA-templated (GO:0006351)	1.91	2	EYA4, PRDM16
negative regulation of cell motility (GO:2000146)	4.36	2	TPM1, VCL
nucleoside phosphate metabolic process (GO:0006753)	3.71	2	MYH7, MYH6
positive regulation of kinase activity (GO:0033674)	3.54	2	RAF1, PSEN1
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	PSEN1, PRDM16
regulation of cell morphogenesis (GO:0022604)	3.4	2	TPM1, PSEN1
protein folding (GO:0006457)	4.32	2	CRYAB, BAG3
purine nucleoside metabolic process (GO:0042278)	4.32	2	MYH7, MYH6
RNA biosynthetic process (GO:0032774)	1.84	2	EYA4, PRDM16
dephosphorylation (GO:0016311)	4.06	2	EYA4, MYH6
membrane protein proteolysis (GO:0033619)	6.17	2	PSEN2, PSEN1
regulation of cellular protein localization (GO:1903827)	3.43	2	ACTN2, LMNA
single-organism carbohydrate metabolic process (GO:0044723)	3.42	2	FKTN, PSEN1
regulation of MAP kinase activity (GO:0043405)	3.95	2	RAF1, PSEN1
embryo development ending in birth or egg hatching (GO:0009792)	4.35	2	TPM1, MYH6
cellular macromolecule biosynthetic process (GO:0034645)	1.66	2	EYA4, PRDM16
nucleoside monophosphate metabolic process (GO:0009123)	4.54	2	MYH7, MYH6
positive regulation of cell communication (GO:0010647)	2.41	2	RAF1, PSEN1
beta-amyloid metabolic process (GO:0050435)	7.09	2	PSEN2, PSEN1
purine nucleoside monophosphate metabolic process (GO:0009126)	4.69	2	MYH7, MYH6
ribonucleotide metabolic process (GO:0009259)	4.11	2	MYH7, MYH6
negative regulation of MAPK cascade (GO:0043409)	4.74	2	DMD, FKTN
regulation of protein localization (GO:0032880)	2.88	2	ACTN2, LMNA
response to endogenous stimulus (GO:0009719)	2.79	2	PLN, DSG2
regulation of neurogenesis (GO:0050767)	3.21	2	DMD, PSEN1
regulation of cellular response to growth factor stimulus (GO:0090287)	4.29	2	DMD, PRDM16
in utero embryonic development (GO:0001701)	4.4	2	TPM1, MYH6
cardiac muscle cell action potential (GO:0086001)	6.33	2	DMD, SCN5A
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	PSEN1, PRDM16
transition between fast and slow fiber (GO:0014883)	7.78	2	TNNC1, MYH7
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	RAF1, PSEN1
negative regulation of ion transmembrane transporter activity (GO:0032413)	5.74	2	PLN, ACTN2
cardiac muscle hypertrophy (GO:0003300)	6.84	2	TTN, CSRP3
positive regulation of protein metabolic process (GO:0051247)	2.43	2	RAF1, PSEN1
regulation of cell development (GO:0060284)	3.01	2	DMD, PSEN1
positive regulation of neurogenesis (GO:0050769)	3.77	2	DMD, PSEN1
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	PSEN1, PRDM16
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	RAF1, PSEN1
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	2	DMD, RAF1
membrane protein ectodomain proteolysis (GO:0006509)	6.64	2	PSEN2, PSEN1
proteolysis (GO:0006508)	2.73	2	PSEN2, PSEN1
chordate embryonic development (GO:0043009)	4.38	2	TPM1, MYH6
monovalent inorganic cation transport (GO:0015672)	3.74	2	ABCC9, SCN5A
regulation of sodium ion transport (GO:0002028)	5.4	2	DMD, SCN5A
positive regulation of sodium ion transport (GO:0010765)	6.23	2	DMD, SCN5A
multicellular organismal reproductive process (GO:0048609)	3.35	2	LMNA, DSG2
cell proliferation (GO:0008283)	3.23	2	RAF1, PSEN1
regulation of muscle filament sliding speed (GO:0032972)	9.04	2	TNNC1, TNNT2
brown fat cell differentiation (GO:0050873)	6.26	2	LAMA4, PRDM16
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	PSEN1, PRDM16
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	EYA4, PSEN1
negative regulation of ion transport (GO:0043271)	4.94	2	ACTN2, PLN
regulation of skeletal muscle adaptation (GO:0014733)	7.16	2	TNNC1, MYH7
immune response-activating signal transduction (GO:0002757)	3.8	2	RAF1, PSEN1
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	PSEN1, PRDM16
protein processing (GO:0016485)	4.62	2	PSEN2, PSEN1
cell junction assembly (GO:0034329)	4.86	2	ACTN2, VCL
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	2	MYH7, MYH6
regulation of immune response (GO:0050776)	2.98	2	RAF1, PSEN1
protein maturation (GO:0051604)	4.48	2	PSEN2, PSEN1
regulation of cellular response to heat (GO:1900034)	5.41	2	CRYAB, BAG3
carbohydrate derivative metabolic process (GO:1901135)	3.07	2	MYH7, MYH6
regulation of binding (GO:0051098)	4.08	2	PLN, PSEN1
negative regulation of cation transmembrane transport (GO:1904063)	5.65	2	PLN, ACTN2
regulation of heart rate by cardiac conduction (GO:0086091)	6.33	2	SCN5A, DSG2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	CSRP3, RAF1
protein localization to organelle (GO:0033365)	3.57	2	CSRP3, LMNA
system development (GO:0048731)	2.92	2	FKTN, SDHA
gland development (GO:0048732)	4.15	2	RAF1, PSEN1
positive regulation of protein kinase activity (GO:0045860)	3.61	2	RAF1, PSEN1
embryo development (GO:0009790)	4.2	2	TPM1, MYH6
activation of MAPKK activity (GO:0000186)	5.74	2	RAF1, PSEN1
adherens junction assembly (GO:0034333)	6.2	2	ACTN2, VCL
adherens junction organization (GO:0034332)	5.48	2	ACTN2, VCL
skeletal muscle thin filament assembly (GO:0030240)	8.12	2	TTN, ACTC1
mitotic cell cycle process (GO:1903047)	3.12	2	TTN, LMNA
regulation of calcium ion transmembrane transport (GO:1903169)	4.98	2	PLN, DMD
positive regulation of cell death (GO:0010942)	3.32	2	PSEN2, PSEN1
cell cycle process (GO:0022402)	2.75	2	TTN, LMNA
purine-containing compound metabolic process (GO:0072521)	4.0	2	MYH7, MYH6
negative regulation of transmembrane transport (GO:0034763)	5.38	2	PLN, ACTN2
fat cell differentiation (GO:0045444)	5.02	2	LAMA4, PRDM16
regulation of muscle adaptation (GO:0043502)	5.78	2	TNNC1, MYH7
regulation of action potential (GO:0098900)	6.07	2	SCN5A, DSG2
positive regulation of immune response (GO:0050778)	3.4	2	RAF1, PSEN1
protein glycosylation (GO:0006486)	4.2	2	FKTN, PSEN1
glycosyl compound metabolic process (GO:1901657)	4.04	2	MYH7, MYH6
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	2	CRYAB, RAF1
negative regulation of cysteine-type endopeptidase activity (GO:2000117)	5.25	2	CRYAB, RAF1
regulation of growth (GO:0040008)	3.26	2	CRYAB, MYH6
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	PSEN1, PRDM16
positive regulation of apoptotic process (GO:0043065)	3.38	2	PSEN2, PSEN1
regulation of nervous system development (GO:0051960)	3.1	2	DMD, PSEN1
positive regulation of heart rate (GO:0010460)	6.59	2	TPM1, SCN5A
thymus development (GO:0048538)	5.88	2	RAF1, PSEN1
hematopoietic or lymphoid organ development (GO:0048534)	4.49	2	RAF1, PSEN1
positive regulation of programmed cell death (GO:0043068)	3.38	2	PSEN2, PSEN1
ribonucleoside metabolic process (GO:0009119)	4.21	2	MYH7, MYH6
negative regulation of cell migration (GO:0030336)	4.41	2	TPM1, VCL
detection of abiotic stimulus (GO:0009582)	4.96	2	TTN, CSRP3
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	PSEN1, PRDM16
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	RAF1, PSEN1
regulation of peptidase activity (GO:0052547)	3.75	2	CRYAB, RAF1
regulation of endopeptidase activity (GO:0052548)	3.8	2	CRYAB, RAF1
adult heart development (GO:0007512)	7.16	2	MYH7, MYH6
glycosylation (GO:0070085)	4.16	2	FKTN, PSEN1
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	PSEN1, PRDM16
reproductive process (GO:0022414)	2.55	2	LMNA, DSG2
macromolecule biosynthetic process (GO:0009059)	1.61	2	EYA4, PRDM16
nucleotide metabolic process (GO:0009117)	3.73	2	MYH7, MYH6
nucleoside metabolic process (GO:0009116)	4.12	2	MYH7, MYH6
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	PSEN1, PRDM16
establishment of localization in cell (GO:0051649)	2.47	2	RAF1, LMNA
negative regulation of endopeptidase activity (GO:0010951)	4.26	2	CRYAB, RAF1
neurogenesis (GO:0022008)	5.45	2	PSEN1, PRDM16
positive regulation of signaling (GO:0023056)	2.41	2	RAF1, PSEN1
positive regulation of transporter activity (GO:0032411)	5.44	2	ACTN2, DMD
regulation of calcium ion transmembrane transporter activity (GO:1901019)	5.49	2	PLN, DMD
negative regulation of locomotion (GO:0040013)	4.22	2	TPM1, VCL
microtubule-based process (GO:0007017)	3.54	2	CRYAB, LMNA
carbohydrate metabolic process (GO:0005975)	3.26	2	FKTN, PSEN1
nervous system development (GO:0007399)	3.53	2	FKTN, SDHA
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	5.44	2	PLN, DMD
regulation of calcium ion transport (GO:0051924)	4.38	2	PLN, DMD
ribose phosphate metabolic process (GO:0019693)	4.06	2	MYH7, MYH6
chromatin organization (GO:0006325)	3.28	2	EYA4, PRDM16
response to ketone (GO:1901654)	4.53	2	PLN, DSG2
response to hormone (GO:0009725)	3.33	2	PLN, DSG2
activation of immune response (GO:0002253)	3.67	2	RAF1, PSEN1
immune effector process (GO:0002252)	3.58	2	ABCC9, PSEN1
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	2	EYA4, PRDM16
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	RAF1, PSEN1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
response to abiotic stimulus (GO:0009628)	-	2.8	0.0	ACTN2, CSRP3, CRYAB, TNNT2, MYH6, TTN, DES, ACTC1, TPM1, MYPN, LMNA, TNNI3, PSEN2, VCL, PSEN1, RAF1, ABCC9, SCN5A, DMD, MYBPC3, BAG3
hemostasis (GO:0007599)	NEW	4.5	0.012	ACTN2, PLN, TPM1, MYH7, TTN, DES, PSEN1, TNNI3, VCL, RAF1, DMD, BAG3
blood coagulation (GO:0007596)	NEW	4.52	0.011	ACTN2, PLN, TPM1, MYH7, TTN, DES, PSEN1, TNNI3, VCL, RAF1, DMD, BAG3
behavior (GO:0007610)	NEW	3.47	0.0	ACTN2, CRYAB, SCN5A, RAF1, EYA4, ACTC1, TPM1, PSEN1, TNNI3, VCL, MYH6, LDB3, PSEN2, DMD, MYBPC3
muscle system process (GO:0003012)	-	4.18	0.0	ACTN2, PLN, CRYAB, SCN5A, MYH7, CSRP3, TNNC1, ACTC1, DES, TPM1, MYH6, TNNI3, TTN, VCL, PSEN2, DMD, MYBPC3
circulatory system process (GO:0003013)	-	4.38	0.0	ACTN2, PLN, TPM1, MYH6, ACTC1, VCL, TNNI3, PSEN1, DMD
heart process (GO:0003015)	-	7.02	0.012	TNNI3, DES, ACTC1
action potential (GO:0001508)	-	5.42	0.035	PLN, SCN5A, DMD, DES, DSG2
regulation of phosphate metabolic process (GO:0019220)	-	2.35	0.006	PLN, TPM1, TNNT2, LMNA, TNNC1, PSEN1, TNNI3, TTN, RAF1, MYH6, FKTN, PSEN2, DMD, MYBPC3
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.005	ACTN2, CSRP3, CRYAB, TNNT2, LMNA, EYA4, TTN, DES, LAMA4, ACTC1, TPM1, PSEN1, VCL, RAF1, MYBPC3, MYH6, LDB3, DSG2, MYPN, DMD, PLN
muscle organ development (GO:0007517)	-	4.98	0.0	ACTN2, SGCD, TNNT2, LMNA, MYH7, CRYAB, MYPN, RAF1, MYH6, FKTN, SCN5A, DMD, MYBPC3
negative regulation of signal transduction (GO:0009968)	-	2.75	0.049	ACTN2, CSRP3, CRYAB, FKTN, EYA4, ACTC1, TPM1, MYH6, LMNA, TNNI3, VCL, RAF1, PSEN1, PRDM16, PSEN2, DMD
adult heart development (GO:0007512)	-	7.16	0.004	TTN, ACTN2, DMD, MYH7, MYH6
striated muscle myosin thick filament assembly (GO:0071688)	NEW	8.63	0.041	TTN, MYBPC3
response to mechanical stimulus (GO:0009612)	-	4.41	0.0	ACTN2, TPM1, MYH6, TTN, CSRP3, MYPN, TNNI3, VCL, DMD, BAG3
protein localization (GO:0008104)	-	2.36	0.017	ACTN2, PLN, CSRP3, SCN5A, RAF1, MYH7, ACTC1, DES, VCL, LMNA, LDB3, DMD
organ development (GO:0048513)	-	2.53	0.0	SGCD, FKTN, MYH7, TTN, CRYAB, PSEN1, LMNA, TNNI3, RAF1, RBM20, PRDM16, MYH6, PSEN2, DMD, BAG3
cellular homeostasis (GO:0019725)	-	3.23	0.01	ACTN2, PLN, CSRP3, SCN5A, ACTC1, DES, PSEN1, TNNI3, VCL, MYH6, PSEN2, DMD, MYBPC3
muscle contraction (GO:0006936)	-	4.37	0.0	ACTN2, CSRP3, CRYAB, SCN5A, MYH7, TNNC1, ACTC1, DES, TPM1, MYH6, TNNI3, TTN, VCL, PSEN2, MYBPC3, DMD
positive regulation of transport (GO:0051050)	-	2.9	0.018	ACTN2, PLN, TPM1, SCN5A, LMNA, ACTC1, DES, PSEN1, RAF1, MYPN, LDB3, PSEN2, DMD, MYBPC3, NEXN
negative regulation of ATPase activity (GO:0032780)	-	7.16	0.0	PLN, TNNI3, TNNT2
positive regulation of ATPase activity (GO:0032781)	-	5.99	0.03	ACTN2, MYBPC3, TNNT2, TPM1
response to calcium ion (GO:0051592)	-	4.98	0.029	ACTN2, SCN5A, TTN, ACTC1, TNNT2, DMD
actin filament-based movement (GO:0030048)	-	5.54	0.0	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, DMD, MYBPC3
response to metal ion (GO:0010038)	-	3.91	0.0	ACTN2, PLN, TPM1, TNNT2, TTN, DES, ACTC1, PSEN1, TNNC1, PSEN2, SCN5A, DMD
oxoacid metabolic process (GO:0043436)	NEW	3.12	0.003	ACTN2, TPM1, TNNT2, LMNA, MYH7, DES, ACTC1, CRYAB, MYH6, TNNI3, VCL, RAF1, PSEN1, MYPN, DMD, BAG3, SDHA
response to inorganic substance (GO:0010035)	-	3.56	0.0	ACTN2, PLN, CRYAB, TNNT2, TNNC1, ACTC1, DES, TPM1, PSEN1, TTN, RAF1, PSEN2, SCN5A, DMD
skeletal muscle contraction (GO:0003009)	-	6.33	0.003	ACTN2, TNNC1, DMD, MYBPC3
system process (GO:0003008)	-	2.3	0.0	ACTN2, PLN, TPM1, SCN5A, MYH7, CSRP3, TNNC1, ACTC1, EYA4, DES, CRYAB, PSEN1, TNNI3, TTN, VCL, MYH6, PSEN2, DMD, MYBPC3
single-multicellular organism process (GO:0044707)	-	1.78	0.0	EYA4, TPM1, VCL, MYH6, DMD, PLN, SCN5A, RAF1, CRYAB, MYH7, ACTC1, PSEN1, TNNI3, PRDM16, MYBPC3, ACTN2, CSRP3, TNNC1, DES, DSG2, TTN, PSEN2
regulation of striated muscle contraction (GO:0006942)	-	5.38	0.004	ACTN2, PLN, SCN5A, MYH6, DMD, MYBPC3
muscle tissue morphogenesis (GO:0060415)	-	5.62	0.0	ACTN2, TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYPN, DMD, MYBPC3
calcium ion homeostasis (GO:0055074)	-	3.97	0.011	ACTN2, PLN, CSRP3, MYH7, DES, PSEN1, TNNI3, PSEN2, DMD
regulation of membrane potential (GO:0042391)	-	3.89	0.002	ACTN2, PLN, SCN5A, DSG2, ACTC1, DES, PSEN1, MYH6, LMNA, DMD
regulation of catabolic process (GO:0009894)	NEW	3.52	0.008	ACTN2, PLN, TPM1, TNNT2, MYH7, TNNC1, DES, CRYAB, MYH6, TNNI3, VCL, PSEN1, RAF1, PSEN2, SCN5A, DMD, MYBPC3
cellular component assembly (GO:0022607)	-	2.14	0.028	ACTN2, PLN, CRYAB, MYH6, TTN, ACTC1, CSRP3, VCL, PSEN1, RAF1, DMD, MYBPC3
regulation of body fluid levels (GO:0050878)	NEW	3.76	0.004	ACTN2, PLN, TPM1, SCN5A, RAF1, MYH7, TTN, DES, PSEN1, TNNI3, VCL, LMNA, DMD, BAG3
regulation of cellular localization (GO:0060341)	-	3.03	0.0	ACTN2, PLN, TPM1, TNNT2, LMNA, CSRP3, NEXN, DES, ACTC1, CRYAB, MYH6, MYPN, VCL, RAF1, PSEN1, LDB3, PSEN2, TNNC1, DMD, MYBPC3, BAG3
detection of abiotic stimulus (GO:0009582)	-	4.96	0.0	ACTN2, TPM1, TNNT2, TTN, DES, CSRP3, PSEN1, TNNI3, MYH6, RAF1, PSEN2, DMD, MYBPC3
cellular component movement (GO:0006928)	-	2.61	0.0	ACTN2, TPM1, TNNT2, MYH6, MYH7, TTN, DES, ACTC1, PSEN1, TNNI3, TNNC1, VCL, RAF1, DMD, MYBPC3
regulation of cell migration (GO:0030334)	-	3.23	0.004	ACTN2, CSRP3, CRYAB, SCN5A, RAF1, ACTC1, LAMA4, DES, TPM1, VCL, NEXN, LMNA, DMD, BAG3
response to muscle stretch (GO:0035994)	-	6.78	0.025	TTN, CSRP3
detection of muscle stretch (GO:0035995)	-	8.34	0.012	TTN, CSRP3
positive regulation of hydrolase activity (GO:0051345)	-	2.91	0.008	ACTN2, TPM1, TNNT2, MYH6, MYH7, DES, ACTC1, PSEN1, TNNI3, RAF1, VCL, LMNA, PSEN2, DMD, MYBPC3, BAG3
cellular component organization (GO:0016043)	-	1.24	0.004	ACTN2, PLN, CRYAB, TNNT2, DSG2, CSRP3, TTN, DES, LAMA4, EYA4, ACTC1, TPM1, PSEN1, LMNA, VCL, RAF1, MYPN, LDB3, MYH6, MYBPC3, DMD
inorganic cation transmembrane transport (GO:0098662)	-	3.55	0.038	ACTN2, TPM1, SCN5A, ACTC1, PSEN1, TNNI3, ABCC9, PSEN2, DMD, NEXN
regulation of molecular function (GO:0065009)	-	1.78	0.045	ACTN2, PLN, CRYAB, TNNT2, RAF1, TNNC1, TPM1, PSEN1, TNNI3, TTN, MYH6, LMNA, PSEN2, DMD, MYBPC3
regulation of biological quality (GO:0065008)	-	1.68	0.0	ACTN2, PLN, TPM1, SCN5A, DSG2, MYH7, TNNC1, CSRP3, MYH6, TNNI3, TTN, VCL, PSEN1, RAF1, PSEN2, DMD, MYBPC3, BAG3
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.0	ACTN2, CSRP3, CRYAB, TNNT2, RAF1, TTN, DES, ACTC1, TPM1, PSEN1, TNNI3, MYH6, LDB3, PSEN2, SCN5A, DMD, MYBPC3, BAG3
organ morphogenesis (GO:0009887)	-	3.55	0.005	ACTN2, CRYAB, TNNT2, TTN, DES, ACTC1, TPM1, PSEN1, MYH6, PSEN2, SCN5A, DMD, MYBPC3
divalent inorganic cation homeostasis (GO:0072507)	-	3.9	0.016	ACTN2, PLN, CSRP3, MYH7, DES, PSEN1, TNNI3, PSEN2, DMD
regulation of heart contraction (GO:0008016)	-	4.35	0.0	ACTN2, PLN, TPM1, TNNT2, MYH7, DES, CSRP3, MYH6, DSG2, SCN5A, DMD, MYBPC3
coagulation (GO:0050817)	NEW	4.51	0.011	ACTN2, PLN, TPM1, MYH7, TTN, DES, PSEN1, TNNI3, VCL, RAF1, DMD, BAG3
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.0	PLN, TPM1, TNNT2, DSG2, MYH7, TNNC1, LAMA4, DES, CSRP3, PSEN1, TNNI3, TTN, MYH6, PRDM16, PSEN2, SCN5A, DMD, MYBPC3
cellular divalent inorganic cation homeostasis (GO:0072503)	-	3.96	0.009	ACTN2, PLN, CSRP3, MYH7, DES, PSEN1, TNNI3, PSEN2, DMD
single-organism developmental process (GO:0044767)	-	1.49	0.0	EYA4, SGCD, VCL, FKTN, DMD, TNNT2, TPM1, BAG3, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, PRDM16, SCN5A, MYBPC3, NEXN, CSRP3, TNNC1, LAMA4, MYH6, TTN, PSEN2
detection of stimulus (GO:0051606)	-	3.22	0.0	ACTN2, TPM1, TNNT2, LMNA, TTN, DES, CSRP3, PSEN1, TNNI3, MYH6, RAF1, PSEN2, DMD, MYBPC3, NEXN
regulation of system process (GO:0044057)	-	3.53	0.0	ACTN2, PLN, CRYAB, TNNT2, MYH6, MYH7, CSRP3, TNNC1, DES, TPM1, VCL, TNNI3, TTN, PSEN1, RAF1, DSG2, SCN5A, DMD, MYBPC3
sensory organ development (GO:0007423)	-	4.82	0.008	ACTN2, CRYAB, ACTC1, PSEN1, MYH6, PRDM16, DMD
regulation of cell motility (GO:2000145)	-	3.16	0.007	ACTN2, CSRP3, CRYAB, SCN5A, RAF1, ACTC1, LAMA4, DES, TPM1, VCL, NEXN, LMNA, DMD, BAG3
regulation of nucleotide metabolic process (GO:0006140)	NEW	4.38	0.003	ACTN2, PLN, TPM1, TNNT2, MYH6, MYH7, TNNC1, DES, PSEN1, TNNI3, VCL, RAF1, PSEN2, DMD, MYBPC3
ion homeostasis (GO:0050801)	-	3.42	0.013	ACTN2, PLN, CSRP3, SCN5A, ACTC1, DES, PSEN1, TNNI3, MYH6, RAF1, PSEN2, DMD
cellular component assembly involved in morphogenesis (GO:0010927)	-	4.29	0.04	ACTN2, CSRP3, TTN, ACTC1, MYH6, LDB3, MYBPC3, DMD
striated muscle contraction (GO:0006941)	-	5.37	0.0	ACTN2, TPM1, SCN5A, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, TTN, PSEN2, MYBPC3, DMD
regulation of smooth muscle contraction (GO:0006940)	NEW	5.63	0.01	TNNI3, MYBPC3, RAF1, TPM1, VCL
heart contraction (GO:0060047)	-	7.02	0.012	TNNI3, DES, ACTC1
muscle structure development (GO:0061061)	-	4.96	0.0	ACTN2, CRYAB, TNNT2, LMNA, MYH7, SGCD, MYH6, RAF1, MYPN, FKTN, SCN5A, MYBPC3, DMD
cardiac muscle cell development (GO:0055013)	-	6.4	0.0	TTN, MYH6, TNNI3, LMNA, DMD, NEXN
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.0	TPM1, TNNT2, MYH7, TTN, ACTC1, EYA4, PSEN1, TNNI3, TNNC1, VCL, MYH6, PSEN2, SCN5A, MYBPC3
cardiac muscle contraction (GO:0060048)	-	5.88	0.0	TPM1, SCN5A, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, TTN, PSEN2, MYBPC3, DMD
single-organism process (GO:0044699)	-	0.48	0.019	EYA4, NEXN, SGCD, VCL, MYH6, FKTN, DMD, PLN, TNNT2, TPM1, MYPN, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, PRDM16, SCN5A, MYBPC3, BAG3, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, PSEN2
ventricular cardiac muscle cell action potential (GO:0086005)	NEW	7.02	0.0	SCN5A, DMD, DES, DSG2
organelle assembly (GO:0070925)	-	3.75	0.017	ACTN2, CSRP3, SCN5A, TTN, ACTC1, PSEN1, MYH6, LDB3, MYBPC3, DMD
cardiac muscle cell action potential (GO:0086001)	-	6.33	0.0	ACTN2, DES, DMD, SCN5A, DSG2
cardiac muscle cell action potential involved in contraction (GO:0086002)	NEW	6.47	0.0	ACTN2, SCN5A, DMD, DES, DSG2
regulation of nucleotide catabolic process (GO:0030811)	NEW	8.34	0.0	ACTN2, PLN, TPM1, TNNT2, MYH7, TNNC1, DES, MYH6, TNNI3, VCL, PSEN1, RAF1, PSEN2, DMD, MYBPC3
regulation of the force of heart contraction (GO:0002026)	-	6.4	0.0	ACTN2, PLN, CSRP3, MYH7, MYH6, DMD, MYBPC3
regulation of heart rate (GO:0002027)	-	5.29	0.0	ACTN2, PLN, TPM1, SCN5A, MYH7, DES, MYH6, DSG2, DMD, MYBPC3
actin-myosin filament sliding (GO:0033275)	-	6.09	0.0	ACTN2, TPM1, TNNT2, MYH7, TTN, DES, ACTC1, MYH6, TNNI3, TNNC1, DMD, MYBPC3
biological adhesion (GO:0022610)	-	2.81	0.001	ACTN2, CSRP3, CRYAB, TNNT2, DSG2, LAMA4, DES, TPM1, MYH6, PSEN1, VCL, LDB3, PSEN2, SCN5A, DMD, MYBPC3, BAG3
developmental process (GO:0032502)	-	1.36	0.0	EYA4, SGCD, VCL, FKTN, DMD, PLN, TNNT2, TPM1, BAG3, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, CSRP3, TNNC1, LAMA4, MYH6, TTN, PSEN2
muscle cell development (GO:0055001)	-	5.29	0.0	ACTN2, TPM1, TTN, PSEN1, MYH6, LMNA, DMD, NEXN
striated muscle cell development (GO:0055002)	-	5.42	0.0	ACTN2, TPM1, TTN, PSEN1, MYH6, LMNA, DMD, NEXN
cardiac myofibril assembly (GO:0055003)	-	7.02	0.004	TTN, CSRP3, ACTC1, TPM1
cardiac cell development (GO:0055006)	-	6.33	0.0	TTN, MYH6, TNNI3, LMNA, DMD, NEXN
heart development (GO:0007507)	-	4.24	0.001	ACTN2, CRYAB, MYH7, TTN, PSEN1, TNNI3, MYH6, RAF1, DMD, RBM20
cardiac muscle tissue morphogenesis (GO:0055008)	-	5.8	0.0	ACTN2, TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYPN, MYBPC3
cellular calcium ion homeostasis (GO:0006874)	-	4.01	0.007	ACTN2, PLN, CSRP3, MYH7, DES, PSEN1, TNNI3, PSEN2, DMD
regulation of muscle filament sliding (GO:0032971)	-	8.34	0.012	TNNC1, MYBPC3
regulation of actin filament-based process (GO:0032970)	-	3.97	0.007	ACTN2, PLN, TPM1, SCN5A, TNNC1, ACTC1, DES, VCL, DMD, MYBPC3
regulation of purine nucleotide metabolic process (GO:1900542)	NEW	4.41	0.003	ACTN2, PLN, TPM1, TNNT2, MYH7, TNNC1, DES, MYH6, TNNI3, VCL, PSEN1, RAF1, PSEN2, DMD, MYBPC3
sarcomere organization (GO:0045214)	-	6.4	0.0	ACTN2, TPM1, TNNT2, TTN, MYPN, MYH6, LDB3, DMD, MYBPC3
actin cytoskeleton organization (GO:0030036)	-	4.1	0.0	ACTN2, TPM1, TNNT2, MYH6, TNNC1, ACTC1, CSRP3, VCL, TTN, RAF1, MYPN, LDB3, DMD, MYBPC3
regulation of localization (GO:0032879)	-	1.94	0.034	ACTN2, PLN, CRYAB, SCN5A, RAF1, TNNC1, LAMA4, TPM1, VCL, LMNA, DMD, MYBPC3, NEXN
cardiac conduction (GO:0061337)	-	5.54	0.003	ACTN2, PLN, SCN5A, DSG2
organic acid metabolic process (GO:0006082)	NEW	3.01	0.004	ACTN2, CRYAB, TNNT2, MYH6, MYH7, DES, ACTC1, TPM1, PSEN1, TNNI3, VCL, RAF1, MYPN, LMNA, DMD, BAG3, SDHA
cardiac muscle fiber development (GO:0048739)	-	7.65	0.0	TNNI3, TTN, MYH6, NEXN
system development (GO:0048731)	-	2.92	0.05	ACTN2, CRYAB, TNNT2, RAF1, MYH7, MYPN, CSRP3, MYH6, VCL, FKTN, PSEN2, SCN5A, DMD, PSEN1, SDHA
myosin filament assembly (GO:0031034)	NEW	8.63	0.041	TTN, MYBPC3, TPM1
myosin filament organization (GO:0031033)	NEW	8.63	0.0	TTN, MYBPC3, TPM1
actomyosin structure organization (GO:0031032)	-	5.4	0.0	ACTN2, TPM1, TNNT2, TNNC1, ACTC1, CSRP3, MYH6, TTN, MYPN, LDB3, DMD, MYBPC3
regulation of cellular catabolic process (GO:0031329)	NEW	3.83	0.012	ACTN2, PLN, TPM1, TNNT2, TNNC1, DES, CRYAB, PSEN1, TNNI3, VCL, MYH6, RAF1, PSEN2, SCN5A, DMD, MYBPC3
ventricular cardiac muscle tissue morphogenesis (GO:0055010)	-	6.07	0.0	TPM1, TNNT2, MYH7, TNNC1, MYH6, TNNI3, MYBPC3
skeletal muscle myosin thick filament assembly (GO:0030241)	NEW	8.63	0.041	TTN, MYBPC3
skeletal muscle thin filament assembly (GO:0030240)	-	8.12	0.041	TTN, ACTC1
carboxylic acid metabolic process (GO:0019752)	NEW	3.12	0.027	ACTN2, CRYAB, LMNA, MYH7, DES, ACTC1, TPM1, PSEN1, TNNI3, RAF1, MYH6, MYPN, DMD, BAG3, SDHA
striated muscle tissue development (GO:0014706)	-	5.23	0.036	PLN, CSRP3, MYH7, DES, TPM1, DMD
multicellular organismal process (GO:0032501)	-	1.45	0.0	EYA4, TPM1, VCL, MYH6, DMD, PLN, SCN5A, RAF1, CRYAB, MYH7, ACTC1, PSEN1, TNNI3, PRDM16, MYBPC3, ACTN2, CSRP3, TNNC1, DES, DSG2, TTN, PSEN2
regulation of ATPase activity (GO:0043462)	-	5.59	0.0	PLN, TPM1, TNNT2, TNNC1, MYH6, TNNI3, MYBPC3
regulation of actin filament-based movement (GO:1903115)	-	6.33	0.0	ACTN2, PLN, SCN5A, TNNC1, MYH6, DMD, MYBPC3
detection of mechanical stimulus (GO:0050982)	-	5.94	0.001	ACTN2, TTN, CSRP3, TNNI3, MYH6
regulation of muscle contraction (GO:0006937)	-	4.75	0.0	ACTN2, PLN, CRYAB, TNNT2, TNNC1, TPM1, VCL, TNNI3, MYH6, RAF1, SCN5A, DMD, MYBPC3
regulation of locomotion (GO:0040012)	-	3.12	0.02	ACTN2, CSRP3, CRYAB, SCN5A, LMNA, ACTC1, LAMA4, DES, TPM1, VCL, NEXN, RAF1, DMD, BAG3
tissue morphogenesis (GO:0048729)	-	3.87	0.0	ACTN2, CRYAB, TNNT2, MYH6, MYH7, TNNC1, DES, ACTC1, TPM1, PSEN1, TNNI3, TTN, VCL, MYPN, DMD, MYBPC3
muscle filament sliding (GO:0030049)	-	6.09	0.0	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, DMD, MYBPC3
detection of external stimulus (GO:0009581)	-	4.98	0.0	ACTN2, TPM1, TNNT2, TTN, DES, CSRP3, PSEN1, TNNI3, MYH6, RAF1, PSEN2, DMD, MYBPC3
regulation of purine nucleotide catabolic process (GO:0033121)	NEW	8.34	0.0	ACTN2, PLN, TPM1, TNNT2, MYH7, TNNC1, DES, MYH6, TNNI3, VCL, PSEN1, RAF1, PSEN2, DMD, MYBPC3
negative regulation of muscle contraction (GO:0045932)	NEW	6.68	0.004	PLN, MYBPC3, MYH6, VCL
actin filament-based process (GO:0030029)	-	3.94	0.0	ACTN2, TPM1, TNNT2, LDB3, MYH7, TNNC1, DES, ACTC1, CSRP3, VCL, TNNI3, TTN, RAF1, MYPN, LMNA, MYH6, DMD, MYBPC3
myofibril assembly (GO:0030239)	-	6.43	0.0	TTN, CSRP3, ACTC1, MYBPC3, MYH6
muscle fiber development (GO:0048747)	-	5.8	0.0	ACTN2, TTN, PSEN1, MYH6, DMD, NEXN
regulation of phosphorus metabolic process (GO:0051174)	-	2.35	0.006	PLN, TPM1, TNNT2, LMNA, TNNC1, PSEN1, TNNI3, TTN, RAF1, MYH6, FKTN, PSEN2, DMD, MYBPC3
regulation of muscle system process (GO:0090257)	-	4.51	0.0	ACTN2, PLN, CRYAB, TNNT2, TNNC1, DES, TPM1, VCL, TNNI3, TTN, MYH6, RAF1, SCN5A, DMD, MYBPC3
single-organism intracellular transport (GO:1902582)	NEW	3.59	0.049	ACTN2, PLN, CRYAB, TNNT2, MYH7, EYA4, ACTC1, TPM1, PSEN1, TNNI3, VCL, MYH6, LMNA, PSEN2, DMD
cell adhesion (GO:0007155)	-	2.82	0.001	ACTN2, CSRP3, TPM1, TNNT2, DSG2, LAMA4, DES, CRYAB, MYH6, VCL, PSEN1, LDB3, PSEN2, SCN5A, MYBPC3, DMD, BAG3
regulation of nucleoside metabolic process (GO:0009118)	NEW	5.82	0.0	ACTN2, PLN, TPM1, TNNT2, MYH6, MYH7, TNNC1, DES, PSEN1, TNNI3, VCL, RAF1, PSEN2, DMD, MYBPC3
cellular protein complex assembly (GO:0043623)	-	3.9	0.019	ACTN2, CRYAB, TTN, ACTC1, DES, TPM1, TNNI3, DMD, MYBPC3
organelle organization (GO:0006996)	-	2.02	0.006	CSRP3, CRYAB, TNNT2, RAF1, TTN, DES, ACTC1, TPM1, PSEN1, LMNA, MYH6, LDB3, MYPN, MYBPC3
actin filament organization (GO:0007015)	-	4.54	0.0	ACTN2, TPM1, MYH7, TTN, ACTC1, CSRP3, VCL, MYPN, DMD, MYBPC3
regulation of cellular component movement (GO:0051270)	-	3.08	0.0	ACTN2, PLN, CRYAB, TNNT2, LMNA, CSRP3, TNNC1, ACTC1, LAMA4, DES, TPM1, VCL, TNNI3, RAF1, NEXN, LDB3, SCN5A, DMD, MYBPC3, BAG3
cytoskeleton organization (GO:0007010)	-	3.22	0.0	ACTN2, CSRP3, CRYAB, TNNT2, LMNA, TTN, DES, ACTC1, TPM1, MYH6, TNNC1, RAF1, VCL, LDB3, MYPN, SCN5A, DMD, MYBPC3, BAG3
nervous system development (GO:0007399)	-	3.53	0.028	ACTN2, SCN5A, RAF1, ACTC1, VCL, PSEN1, FKTN, PSEN2, DMD, SDHA
anatomical structure development (GO:0048856)	-	1.58	0.0	EYA4, SGCD, SDHA, FKTN, DMD, PLN, SCN5A, TPM1, NEXN, RAF1, CRYAB, LMNA, MYH7, PSEN1, TNNI3, BAG3, PRDM16, RBM20, CSRP3, TTN, LAMA4, MYH6, PSEN2
single-organism organelle organization (GO:1902589)	-	2.68	0.006	CSRP3, CRYAB, TNNT2, RAF1, TTN, ACTC1, TPM1, MYH6, LMNA, MYPN, LDB3, MYBPC3
muscle tissue development (GO:0060537)	-	5.1	0.006	ACTN2, PLN, TPM1, MYH7, DES, CSRP3, DMD
metal ion transport (GO:0030001)	-	3.36	0.02	ACTN2, PLN, SCN5A, MYH7, ACTC1, PSEN1, TNNI3, PSEN2, RAF1, ABCC9, DMD, NEXN
actin-mediated cell contraction (GO:0070252)	-	5.88	0.0	ACTN2, TPM1, TNNT2, MYH7, TNNC1, DES, ACTC1, MYH6, TNNI3, TTN, MYBPC3, DMD
cation transmembrane transport (GO:0098655)	-	3.43	0.034	ACTN2, TPM1, SCN5A, ACTC1, PSEN1, TNNI3, ABCC9, RAF1, PSEN2, DMD, NEXN

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	35	EYA4, TPM1, VCL, GATAD1, TMPO, FKTN, DMD, PLN, TNNT2, MYH6, SGCD, MYPN, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, BAG3, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, DSG2, TTN, LDB3, PSEN2
intracellular part (GO:0044424)	0.28	34	EYA4, TPM1, VCL, GATAD1, MYPN, FKTN, DMD, PLN, TNNT2, MYH6, SGCD, BAG3, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, TMPO, TTN, LDB3, PSEN2
organelle (GO:0043226)	0.4	33	EYA4, SGCD, VCL, GATAD1, TMPO, FKTN, DMD, PLN, TNNT2, MYH6, TPM1, MYPN, RAF1, RBM20, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, SDHA, PRDM16, SCN5A, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, LDB3, PSEN2
intracellular organelle (GO:0043229)	0.51	31	EYA4, SGCD, VCL, GATAD1, MYPN, FKTN, DMD, PLN, TNNT2, MYH6, TPM1, RBM20, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, SDHA, PRDM16, SCN5A, NEXN, ACTN2, CSRP3, TNNC1, DES, TMPO, TTN, LDB3, PSEN2
cytoplasmic part (GO:0044444)	0.82	30	TPM1, VCL, MYPN, FKTN, DMD, PLN, TNNT2, MYH6, BAG3, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, TMPO, TTN, LDB3, PSEN2
organelle part (GO:0044422)	0.79	30	TPM1, VCL, GATAD1, MYPN, FKTN, DMD, PLN, TNNT2, MYH6, BAG3, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, TMPO, TTN, LDB3, PSEN2
membrane-bounded organelle (GO:0043227)	0.47	25	EYA4, VCL, GATAD1, TMPO, FKTN, DMD, PLN, SCN5A, MYPN, RAF1, CRYAB, LMNA, ACTC1, PSEN1, SDHA, PRDM16, RBM20, ACTN2, CSRP3, TNNC1, LAMA4, DES, DSG2, TTN, PSEN2
intracellular organelle part (GO:0044446)	0.81	22	TPM1, VCL, GATAD1, MYH6, FKTN, PLN, TNNT2, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, SDHA, MYBPC3, ACTN2, TNNC1, DES, TMPO, TTN, PSEN2
cytoplasm (GO:0005737)	1.01	22	EYA4, SGCD, VCL, MYPN, DMD, MYH6, TPM1, BAG3, LMNA, CRYAB, RAF1, MYH7, ACTC1, TNNI3, NEXN, ACTN2, CSRP3, TTN, DES, TMPO, LDB3, PSEN2
contractile fiber part (GO:0044449)	4.53	22	TPM1, VCL, MYPN, DMD, TNNT2, BAG3, CRYAB, MYH7, ACTC1, TNNI3, PSEN2, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, MYH6, TTN, LDB3, ABCC9
membrane (GO:0016020)	0.68	20	ACTN2, DSG2, SGCD, SCN5A, FKTN, PLN, DES, ACTC1, CRYAB, TMPO, LMNA, ABCC9, VCL, RAF1, PSEN1, TPM1, PSEN2, DMD, BAG3, SDHA
non-membrane-bounded organelle (GO:0043228)	1.76	20	ACTN2, CSRP3, SGCD, NEXN, TNNT2, MYH7, TTN, ACTC1, DES, CRYAB, MYH6, PSEN1, TNNI3, TNNC1, VCL, TMPO, LDB3, PSEN2, DMD, TPM1
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	20	ACTN2, CSRP3, CRYAB, NEXN, TNNT2, MYH6, MYH7, TTN, ACTC1, DES, SGCD, TMPO, TNNI3, TNNC1, VCL, PSEN1, LDB3, PSEN2, DMD, TPM1
macromolecular complex (GO:0032991)	1.35	19	PLN, SGCD, TNNT2, MYH7, TTN, PSEN1, TPM1, TMPO, TNNI3, TNNC1, VCL, MYH6, PRDM16, ABCC9, PSEN2, SCN5A, MYBPC3, DMD, SDHA
intracellular membrane-bounded organelle (GO:0043231)	0.6	19	PLN, CSRP3, SCN5A, FKTN, TTN, CRYAB, EYA4, TMPO, LMNA, MYPN, GATAD1, RAF1, PSEN1, PRDM16, PSEN2, TNNC1, DMD, RBM20, SDHA
protein complex (GO:0043234)	1.51	18	PLN, SGCD, TNNT2, MYH6, MYH7, TTN, TPM1, PSEN1, TNNI3, TNNC1, VCL, PRDM16, ABCC9, PSEN2, SCN5A, DMD, MYBPC3, SDHA
cytosol (GO:0005829)	1.68	17	ACTN2, CRYAB, TNNT2, LMNA, TNNC1, DES, ACTC1, TPM1, MYH6, TNNI3, TTN, RAF1, VCL, PRDM16, DMD, MYBPC3, BAG3
cytoskeletal part (GO:0044430)	2.49	16	ACTN2, CRYAB, TNNT2, MYH7, TTN, ACTC1, DES, TPM1, MYH6, TNNI3, TNNC1, VCL, LMNA, PSEN2, MYBPC3, PSEN1
nucleus (GO:0005634)	1.07	14	CRYAB, FKTN, EYA4, TTN, MYPN, CSRP3, PSEN1, LMNA, GATAD1, RAF1, TMPO, PRDM16, DMD, RBM20
Z disc (GO:0030018)	5.11	14	ACTN2, CRYAB, NEXN, SCN5A, MYH7, TTN, DES, CSRP3, MYPN, MYH6, LDB3, PSEN2, DMD, BAG3
membrane part (GO:0044425)	0.95	13	PLN, DSG2, SGCD, SCN5A, TMPO, TPM1, VCL, ABCC9, PSEN1, FKTN, PSEN2, DMD, SDHA
plasma membrane (GO:0005886)	1.39	13	ACTN2, CRYAB, SCN5A, DES, SGCD, VCL, PSEN1, ABCC9, DSG2, RAF1, PSEN2, DMD, BAG3
cytoskeleton (GO:0005856)	2.55	12	ACTN2, CSRP3, CRYAB, TNNC1, ACTC1, DES, SGCD, VCL, NEXN, LDB3, DMD, TPM1
sarcomere (GO:0030017)	5.95	10	ACTN2, TPM1, TNNT2, MYH7, ACTC1, MYH6, TNNI3, MYPN, ABCC9, MYBPC3
integral component of membrane (GO:0016021)	1.14	10	PLN, SGCD, SCN5A, DSG2, TPM1, PSEN1, ABCC9, TMPO, FKTN, PSEN2
vesicle (GO:0031982)	1.64	10	ACTN2, PLN, CRYAB, TTN, ACTC1, LAMA4, DES, PSEN1, VCL, DSG2
intrinsic component of membrane (GO:0031224)	1.13	10	PLN, SGCD, SCN5A, DSG2, TPM1, PSEN1, ABCC9, TMPO, FKTN, PSEN2
extracellular region part (GO:0044421)	1.57	9	ACTN2, CRYAB, TTN, ACTC1, LAMA4, DES, VCL, DSG2, FKTN
cell junction (GO:0030054)	2.75	9	ACTN2, SCN5A, DSG2, ACTC1, DES, VCL, PSEN1, DMD, NEXN
extracellular vesicle (GO:1903561)	1.89	8	ACTN2, CRYAB, TTN, ACTC1, LAMA4, DES, VCL, DSG2
extracellular organelle (GO:0043230)	1.89	8	ACTN2, CRYAB, TTN, ACTC1, LAMA4, DES, DSG2, VCL
organelle membrane (GO:0031090)	1.97	8	PLN, LMNA, PSEN1, RAF1, TMPO, FKTN, PSEN2, SDHA
membrane-bounded vesicle (GO:0031988)	1.71	8	ACTN2, CRYAB, TTN, ACTC1, LAMA4, DES, DSG2, VCL
nuclear part (GO:0044428)	1.55	8	CRYAB, TNNC1, PSEN1, TTN, GATAD1, TMPO, LMNA, PSEN2
contractile fiber (GO:0043292)	5.81	8	CRYAB, TNNT2, MYH7, TNNC1, DES, TPM1, MYH6, TNNI3
cell projection (GO:0042995)	2.47	8	ACTN2, TPM1, RAF1, ACTC1, PSEN1, LDB3, DMD, BAG3
plasma membrane part (GO:0044459)	1.95	8	SGCD, SCN5A, TPM1, PSEN1, ABCC9, DSG2, PSEN2, DMD
extracellular exosome (GO:0070062)	1.89	8	ACTN2, CRYAB, TTN, ACTC1, LAMA4, DES, VCL, DSG2
membrane protein complex (GO:0098796)	2.84	7	PLN, SGCD, SCN5A, PSEN1, SDHA, ABCC9, DMD
anchoring junction (GO:0070161)	3.61	6	ACTN2, ACTC1, DES, DSG2, VCL, NEXN
mitochondrion (GO:0005739)	2.42	6	PLN, CRYAB, TNNC1, SDHA, PSEN1, RAF1
plasma membrane region (GO:0098590)	2.97	5	PSEN2, DMD, SCN5A, TPM1, DSG2
sarcolemma (GO:0042383)	5.2	5	ABCC9, SCN5A, SGCD, DES, DMD
plasma membrane protein complex (GO:0098797)	3.55	5	ABCC9, SGCD, SCN5A, DMD, PSEN1
Golgi apparatus (GO:0005794)	2.7	5	PSEN2, FKTN, CRYAB, RAF1, PSEN1
cell surface (GO:0009986)	3.44	5	CRYAB, DMD, SCN5A, PSEN1, DSG2
intracellular (GO:0005622)	2.37	5	PSEN2, SCN5A, DES, RAF1, PSEN1
myofibril (GO:0030016)	6.14	5	TNNI3, TPM1, TNNT2, MYH7, MYH6
neuron part (GO:0097458)	2.64	5	PSEN2, ACTN2, DMD, BAG3, PSEN1
adherens junction (GO:0005912)	3.66	5	ACTN2, ACTC1, DES, NEXN, VCL
endoplasmic reticulum (GO:0005783)	2.56	5	PSEN2, PLN, SCN5A, FKTN, PSEN1
bounding membrane of organelle (GO:0098588)	2.39	5	PSEN2, PLN, RAF1, FKTN, PSEN1
cell-substrate junction (GO:0030055)	3.82	5	ACTN2, DMD, ACTC1, NEXN, VCL
actin filament bundle (GO:0032432)	5.74	4	CRYAB, MYH7, MYH6, TPM1
membrane raft (GO:0045121)	4.18	4	DMD, SCN5A, VCL, PSEN1
supramolecular fiber (GO:0099512)	3.31	4	ACTN2, DES, ACTC1, LMNA
polymeric cytoskeletal fiber (GO:0099513)	3.31	4	ACTN2, ACTC1, DES, LMNA
endoplasmic reticulum membrane (GO:0005789)	2.95	4	PSEN2, PLN, PSEN1, TMPO
cell-substrate adherens junction (GO:0005924)	3.83	4	ACTN2, ACTC1, NEXN, VCL
focal adhesion (GO:0005925)	3.83	4	ACTN2, ACTC1, NEXN, VCL
I band (GO:0031674)	6.67	4	TTN, CRYAB, ACTC1, MYPN
muscle myosin complex (GO:0005859)	6.86	4	TTN, MYBPC3, MYH7, MYH6
nucleoplasm (GO:0005654)	1.89	4	TNNC1, CRYAB, GATAD1, LMNA
endoplasmic reticulum part (GO:0044432)	2.73	4	PSEN2, PLN, PSEN1, TMPO
myosin complex (GO:0016459)	5.55	4	TTN, MYBPC3, MYH7, MYH6
perinuclear region of cytoplasm (GO:0048471)	3.35	4	PLN, PSEN2, LDB3, LMNA
extracellular region (GO:0005576)	2.18	4	TTN, ACTN2, LAMA4, VCL
membrane region (GO:0098589)	3.95	4	DMD, SCN5A, VCL, PSEN1
nuclear membrane (GO:0031965)	4.2	4	PSEN2, PSEN1, LMNA, TMPO
mitochondrial membrane (GO:0031966)	3.31	4	PLN, RAF1, PSEN1, SDHA
cell-cell junction (GO:0005911)	3.85	4	SCN5A, DES, VCL, DSG2
cell projection part (GO:0044463)	2.97	4	ACTN2, DMD, TPM1, PSEN1
organelle inner membrane (GO:0019866)	3.56	4	PSEN2, PSEN1, TMPO, SDHA
myosin II complex (GO:0016460)	6.54	4	TTN, MYBPC3, MYH7, MYH6
mitochondrial part (GO:0044429)	2.92	4	PLN, RAF1, PSEN1, SDHA
membrane microdomain (GO:0098857)	4.17	4	DMD, SCN5A, VCL, PSEN1
actin cytoskeleton (GO:0015629)	4.39	3	TNNC1, DMD, VCL
intercalated disc (GO:0014704)	5.93	3	DES, SCN5A, DSG2
synapse (GO:0045202)	3.58	3	DMD, DES, PSEN1
transmembrane transporter complex (GO:1902495)	4.06	3	PLN, ABCC9, SCN5A
actomyosin (GO:0042641)	5.66	3	TPM1, MYH7, MYH6
stress fiber (GO:0001725)	5.81	3	TPM1, MYH7, MYH6
myosin filament (GO:0032982)	6.71	3	MYBPC3, MYH7, MYH6
contractile actin filament bundle (GO:0097517)	5.81	3	TPM1, MYH7, MYH6
Golgi apparatus part (GO:0044431)	3.0	3	PSEN2, FKTN, PSEN1
synapse part (GO:0044456)	3.42	3	ACTN2, DMD, PSEN1
neuron projection (GO:0043005)	3.12	3	ACTN2, PSEN1, BAG3
lateral plasma membrane (GO:0016328)	5.89	3	DMD, SCN5A, DSG2
pseudopodium (GO:0031143)	6.97	3	ACTN2, LDB3, RAF1
transporter complex (GO:1990351)	4.04	3	PLN, ABCC9, SCN5A
cell-cell contact zone (GO:0044291)	5.69	3	DES, SCN5A, DSG2
cell body (GO:0044297)	3.74	3	PSEN2, ACTC1, PSEN1
troponin complex (GO:0005861)	7.72	3	TNNI3, TNNC1, TNNT2
myofilament (GO:0036379)	7.16	3	TTN, MYBPC3, TNNT2
filopodium (GO:0030175)	5.48	3	ACTN2, DMD, ACTC1
Golgi membrane (GO:0000139)	3.28	3	PSEN2, FKTN, PSEN1
actin-based cell projection (GO:0098858)	4.83	3	ACTN2, DMD, ACTC1
chromosomal part (GO:0044427)	3.18	3	PSEN2, TMPO, PSEN1
envelope (GO:0031975)	4.62	2	LMNA, TMPO
neuromuscular junction (GO:0031594)	5.81	2	DES, PSEN1
ion channel complex (GO:0034702)	4.18	2	ABCC9, SCN5A
cation channel complex (GO:0034703)	4.69	2	ABCC9, SCN5A
glycoprotein complex (GO:0090665)	7.03	2	SGCD, DMD
intrinsic component of plasma membrane (GO:0031226)	2.53	2	PSEN2, PSEN1
extracellular space (GO:0005615)	2.63	2	ACTC1, FKTN
myelin sheath (GO:0043209)	4.76	2	CRYAB, SDHA
nuclear inner membrane (GO:0005637)	6.02	2	PSEN2, TMPO
whole membrane (GO:0098805)	2.85	2	RAF1, PSEN1
nuclear envelope (GO:0005635)	4.72	2	LMNA, TMPO
microtubule organizing center (GO:0005815)	3.42	2	PSEN2, PSEN1
neuronal cell body (GO:0043025)	3.9	2	PSEN2, PSEN1
organelle outer membrane (GO:0031968)	4.63	2	RAF1, PSEN1
catalytic complex (GO:1902494)	2.9	2	PLN, SDHA
apical plasma membrane (GO:0016324)	4.13	2	PSEN2, DSG2
cell projection membrane (GO:0031253)	4.11	2	DMD, TPM1
organelle envelope (GO:0031967)	4.63	2	TMPO, LMNA
fascia adherens (GO:0005916)	7.5	2	DES, VCL
intermediate filament (GO:0005882)	4.48	2	DES, LMNA
cell-cell adherens junction (GO:0005913)	5.81	2	DES, VCL
actin filament (GO:0005884)	5.81	2	ACTN2, ACTC1
integral component of plasma membrane (GO:0005887)	2.57	2	PSEN2, PSEN1
striated muscle thin filament (GO:0005865)	7.4	2	TTN, TNNT2
kinetochore (GO:0000776)	5.05	2	PSEN2, PSEN1
cortical cytoskeleton (GO:0030863)	5.58	2	ACTN2, VCL
chromosome (GO:0005694)	3.78	2	TTN, TMPO
outer membrane (GO:0019867)	4.6	2	RAF1, PSEN1
cortical actin cytoskeleton (GO:0030864)	6.11	2	ACTN2, VCL
mitochondrial inner membrane (GO:0005743)	3.65	2	PSEN1, SDHA
dystrophin-associated glycoprotein complex (GO:0016010)	7.03	2	SGCD, DMD
costamere (GO:0043034)	6.86	2	DMD, VCL
centrosome (GO:0005813)	3.75	2	PSEN2, PSEN1
cell cortex part (GO:0044448)	5.01	2	ACTN2, VCL

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
actin filament bundle (GO:0032432)	-	5.74	0.0	CRYAB, MYH7, ACTC1, TPM1, MYPN, MYH6, DMD
plasma membrane region (GO:0098590)	-	2.97	0.002	ACTN2, PLN, CSRP3, DSG2, ACTC1, DES, PSEN1, VCL, MYH6, PSEN2, DMD, MYBPC3
actin cytoskeleton (GO:0015629)	-	4.39	0.001	ACTN2, TPM1, TNNC1, CSRP3, VCL, PSEN1, LMNA, DMD
myofilament (GO:0036379)	-	7.16	0.0	TTN, MYBPC3, TNNT2
myofibril (GO:0030016)	-	6.14	0.003	ACTN2, DMD, MYBPC3, MYH6
neuromuscular junction (GO:0031594)	-	5.81	0.0	ACTN2, SCN5A, DES, PSEN1, PSEN2, DMD
sarcomere (GO:0030017)	-	5.95	0.0	ACTN2, TPM1, TNNT2, MYH7, ACTC1, VCL, TNNI3, MYH6, ABCC9, MYBPC3
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.013	ACTN2, CSRP3, SGCD, TTN, NEXN, CRYAB, PSEN1, TNNC1, VCL, MYH6, LDB3, PSEN2, DMD, TPM1
cytoskeletal part (GO:0044430)	-	2.49	0.0	ACTN2, CSRP3, CRYAB, SCN5A, TNNT2, RAF1, MYH7, TTN, DES, MYPN, TPM1, MYH6, TNNI3, ACTC1, VCL, PSEN1, LMNA, PSEN2, TNNC1, DMD, MYBPC3
cell-substrate adherens junction (GO:0005924)	-	3.83	0.0	ACTN2, TPM1, LMNA, MYH7, TNNC1, ACTC1, VCL, RAF1, MYH6, LDB3, DMD, NEXN
focal adhesion (GO:0005925)	-	3.83	0.0	ACTN2, TPM1, LMNA, MYH7, TNNC1, ACTC1, VCL, RAF1, MYH6, LDB3, DMD, NEXN
ciliary rootlet (GO:0035253)	NEW	7.5	0.03	PSEN2, PSEN1
cell junction (GO:0030054)	-	2.75	0.003	ACTN2, TPM1, SCN5A, LDB3, MYH7, TNNC1, DES, ACTC1, PSEN1, LMNA, VCL, RAF1, MYH6, MYPN, DSG2, MYBPC3, DMD, NEXN
cell-substrate junction (GO:0030055)	-	3.82	0.0	ACTN2, TPM1, LMNA, MYH7, TNNC1, ACTC1, VCL, RAF1, MYH6, LDB3, DMD, NEXN
cytoskeleton (GO:0005856)	-	2.55	0.0	ACTN2, CSRP3, SGCD, SCN5A, MYH6, NEXN, ACTC1, DES, CRYAB, PSEN1, LMNA, TNNI3, TNNC1, RAF1, VCL, LDB3, DMD, TPM1
stress fiber (GO:0001725)	-	5.81	0.018	TPM1, MYH7, ACTC1, MYPN, MYH6, DMD
M band (GO:0031430)	NEW	6.76	0.017	TTN, MYBPC3, DES
myosin filament (GO:0032982)	-	6.71	0.003	MYBPC3, MYH7, MYH6
vesicle (GO:0031982)	-	1.64	0.011	TPM1, VCL, MYH6, DMD, PLN, TNNT2, MYPN, LMNA, CRYAB, RAF1, MYH7, ACTC1, PSEN1, TNNI3, PSEN2, SCN5A, MYBPC3, BAG3, ACTN2, CSRP3, TTN, LAMA4, DES, DSG2, ABCC9
A band (GO:0031672)	NEW	7.09	0.002	MYBPC3, DMD, CSRP3
I band (GO:0031674)	-	6.67	0.0	TTN, ACTN2, TPM1, ACTC1, MYPN
mitochondrion (GO:0005739)	-	2.42	0.001	ACTN2, PLN, CRYAB, TNNT2, LMNA, MYH7, CSRP3, TNNC1, DES, ACTC1, TPM1, PSEN1, TNNI3, MYH6, RAF1, ABCC9, DMD, SDHA
muscle myosin complex (GO:0005859)	-	6.86	0.001	MYBPC3, MYH7, MYH6
apical plasma membrane (GO:0016324)	-	4.13	0.0	ACTN2, PLN, CSRP3, DSG2, DES, VCL, PSEN1, MYH6, PSEN2, DMD, MYBPC3
myosin complex (GO:0016459)	-	5.55	0.011	ACTN2, MYBPC3, MYH6, MYH7
Z disc (GO:0030018)	-	5.11	0.0	ACTN2, CRYAB, NEXN, SCN5A, LMNA, MYH7, TTN, DES, ACTC1, CSRP3, PSEN1, MYPN, MYH6, LDB3, PSEN2, DMD, MYBPC3, BAG3
perinuclear region of cytoplasm (GO:0048471)	-	3.35	0.029	ACTN2, PLN, TPM1, LMNA, ACTC1, DES, VCL, RAF1, PSEN1, LDB3, PSEN2, DMD
actomyosin (GO:0042641)	-	5.66	0.031	TPM1, MYH7, ACTC1, MYPN, MYH6, DMD
plasma membrane part (GO:0044459)	-	1.95	0.02	ACTN2, PLN, SGCD, SCN5A, DSG2, CSRP3, ACTC1, DES, CRYAB, PSEN1, LMNA, TNNI3, ABCC9, VCL, RAF1, MYH6, TPM1, PSEN2, MYBPC3, DMD, BAG3
Golgi apparatus (GO:0005794)	-	2.7	0.0	ACTN2, PLN, CRYAB, TNNT2, FKTN, TTN, ACTC1, DES, VCL, LMNA, TNNI3, PSEN1, RAF1, PSEN2, DMD, MYBPC3
membrane region (GO:0098589)	-	3.95	0.014	ACTN2, DSG2, TPM1, SCN5A, MYH6, ACTC1, DES, CSRP3, VCL, LMNA, RAF1, PSEN1, LDB3, PSEN2, DMD, MYBPC3, PLN
sarcolemma (GO:0042383)	-	5.2	0.0	ACTN2, SGCD, SCN5A, DES, ABCC9, DMD
pseudopodium (GO:0031143)	-	6.97	0.002	ACTN2, LDB3, RAF1
cell-cell contact zone (GO:0044291)	-	5.69	0.017	ACTN2, DMD, SCN5A, MYPN
anchoring junction (GO:0070161)	-	3.61	0.0	ACTN2, TPM1, DSG2, MYH7, TNNC1, ACTC1, DES, PSEN1, LMNA, RAF1, VCL, LDB3, MYH6, DMD, NEXN
mitochondrial membrane (GO:0031966)	-	3.31	0.005	ACTN2, PLN, TPM1, TNNT2, ACTC1, PSEN1, TNNI3, SDHA, RAF1, PSEN2
fascia adherens (GO:0005916)	-	7.5	0.002	DES, VCL, PSEN1
cell-cell adherens junction (GO:0005913)	-	5.81	0.0	ACTN2, ACTC1, DES, VCL, PSEN1, DMD
adherens junction (GO:0005912)	-	3.66	0.003	ACTN2, TPM1, MYH6, MYH7, TNNC1, ACTC1, DES, PSEN1, LMNA, RAF1, VCL, LDB3, DMD, NEXN
cell-cell junction (GO:0005911)	-	3.85	0.0	ACTN2, TPM1, SCN5A, DSG2, ACTC1, DES, VCL, RAF1, PSEN1, MYPN, DMD
striated muscle thin filament (GO:0005865)	-	7.4	0.01	TTN, TNNT2
cell projection (GO:0042995)	-	2.47	0.016	ACTN2, PLN, CRYAB, SCN5A, LMNA, ACTC1, DES, TPM1, TMPO, PSEN1, RAF1, VCL, LDB3, PSEN2, DMD, MYBPC3, BAG3
troponin complex (GO:0005861)	-	7.72	0.0	TNNI3, TNNC1, TNNT2
protein complex (GO:0043234)	-	1.51	0.0	TPM1, SGCD, VCL, MYPN, DMD, PLN, TNNT2, LMNA, CRYAB, RAF1, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, MYH6, LDB3, PSEN2
intercalated disc (GO:0014704)	-	5.93	0.006	ACTN2, DMD, SCN5A, MYPN
basal lamina (GO:0005605)	NEW	7.09	0.015	ACTN2, LAMA4, ACTC1
macromolecular complex (GO:0032991)	-	1.35	0.0	TPM1, SGCD, VCL, MYPN, DMD, PLN, TNNT2, MYH6, BAG3, LMNA, CRYAB, RAF1, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, PRDM16, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, LAMA4, DES, TMPO, LDB3, PSEN2
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.013	ACTN2, CSRP3, CRYAB, TTN, NEXN, SGCD, MYH6, TNNC1, VCL, PSEN1, LDB3, PSEN2, DMD, TPM1
cytosol (GO:0005829)	-	1.68	0.0	ACTN2, CRYAB, TNNT2, RAF1, TNNC1, DES, ACTC1, TPM1, MYH6, TNNI3, TTN, VCL, LMNA, PSEN2, DMD, MYBPC3, BAG3
filopodium membrane (GO:0031527)	NEW	6.91	0.014	DMD, ACTC1, VCL
cytoplasmic part (GO:0044444)	-	0.82	0.001	TPM1, VCL, MYPN, FKTN, DMD, PLN, TNNT2, BAG3, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, MYH6, TTN, LDB3, PSEN2
myosin II complex (GO:0016460)	-	6.54	0.002	MYBPC3, MYH7, MYH6
mitochondrial part (GO:0044429)	-	2.92	0.022	ACTN2, PLN, TPM1, TNNT2, RAF1, ACTC1, PSEN1, TNNI3, SDHA, LMNA, PSEN2, DMD
contractile fiber (GO:0043292)	-	5.81	0.0	ACTN2, TPM1, TNNC1, MYH6, DMD, MYBPC3
organelle part (GO:0044422)	-	0.79	0.0	TPM1, VCL, MYPN, FKTN, DMD, PLN, TNNT2, MYH6, BAG3, RAF1, CRYAB, LMNA, MYH7, ACTC1, PSEN1, TNNI3, ABCC9, SDHA, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, TMPO, TTN, LDB3, PSEN2
contractile fiber part (GO:0044449)	-	4.53	0.0	TPM1, VCL, MYPN, DMD, TNNT2, BAG3, LMNA, CRYAB, MYH7, ACTC1, PSEN1, TNNI3, PSEN2, SCN5A, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, DES, MYH6, TTN, LDB3, ABCC9