Disease table of ALZHEIMER DISEASE OMIM ID: 104300

Gene-disease associations table

Gene	Associated with ALZHEIMER DISEASE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
SORL1	OMIM	HGNC link	11q24.1	1	104300
NOS3	OMIM	HGNC link	7q36.1	4	145500, PS189800, 104300, 601367
ACE	OMIM	HGNC link	17q23.3	5	PS603933, 608446, 267430, 614519, 104300
PLAU	OMIM	HGNC link	10q22.2	3	PS231200, PS142623, 104300
MPO	OMIM	HGNC link	17q22	2	104300, 254600
APP	ClinVar, OMIM, HUMSAVAR	HGNC link	21q21.3	2	104300, 605714
PSEN1	ClinVar	HGNC link	14q24.2	7	607822, 172700, 600274, 104300, PS142690, 606889, PS115200
APBB2	OMIM	HGNC link	4p13	1	104300
PAXIP1	OMIM	HGNC link	7q36.2	1	104300
BLMH	OMIM	HGNC link	17q11.2	1	104300
PSEN2	ClinVar	HGNC link	1q42.13	3	606889, PS115200, 104300
HFE	OMIM	HGNC link	6p22.2	6	PS235200, PS603933, 614193, 104300, 176200, 176100
A2M	OMIM	HGNC link	12p13.31	2	104300, 614036

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
7q36	2	PAXIP1, NOS3

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	2	ACE, MPO
7q3	2	PAXIP1, NOS3

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
7q	2	PAXIP1, NOS3
17q	3	BLMH, ACE, MPO

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
17	3	BLMH, ACE, MPO
7	2	PAXIP1, NOS3

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
HIF1A	NO	80	RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A	2	PLAU, ACE
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	3	PSEN2, PLAU, ACE
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	3	NOS3, PLAU, APP
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	A2M, NOS3, PLAU
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	2	NOS3, PLAU
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	6	MPO, NOS3, PLAU, BLMH, PSEN1, APP
SP3	NO	109	DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC6	2	NOS3, ACE
CREB1	NO	90	NDC80, NRF1, IFNG, NR2F1, CYP19A1, CASP8, LDHA, SMAD6, SLC19A1, GSK3A, IL10, PSEN1, PPP2R2B, JUN, HPGD, IL2, GABPA, MC2R, CRTC1, AR, FLT1, SLC39A1, BDKRB2, NPY, PTGS2, MSMB, CFTR, HMOX1, MITF, AQP3, MUC5AC, STMN1, TRH, PCSK1, MMP2, CYP17A1, NOLC1, PRL, NMNAT2, TLR9, NTS, PLAT, FOS, BCL2L11, MUC4, GSK3B, CYP11B1, PPM1D, CCK, ETV3, PTGES, UXT, HLA-DOB, CGA, XPC, ACACA, SLC22A8, TH, VIP, BDKRB1, CYP11B2, POLD2, LAPTM4B, SOX9, PLAU, SNAI1, PPP2CA, SNAI2, SPRY2, HLA-DQB1, CCL5, CXCR4, ADRA1A, NR5A2, ERBB2, GRPR, BDNF, NR4A3, IL5RA, SLC20A1, RRM2B, LYL1, BCL2, CD4, NR2F6, NF1, IL6, CYP11A1, ODC1, FOXA1	2	PLAU, PSEN1
ATF2	NO	31	FN1, ATF3, PLAU, IMPDH2, IFNG, PLAT, PTGS2, APOC3, NOS3, FAS, MAP3K1, RETN, TNF, PCK2, CYP11B1, CDKN1A, IFNB1, TGFB2, PCK1, JUN, RELA, DUSP10, DUSP1, ITGB8, MMP2, INS, POLB, ST3GAL5, CYP11B2, CCND1, FASLG	2	NOS3, PLAU

regulated gene	associated to this disease	# TFs	TFs
NOS3	YES	11	SP1, GATA4, HDAC1, DDIT3, ATF2, JUN, RELA, SP3, NFKB1, GATA2, KLF2
ACE	YES	4	SP3, HIF1A, CREM, EGR1
PLAU	YES	19	SP1, HIF1A, GATA6, RUNX2, EGR1, NFKB1, ATF4, HOXD3, ILF3, SRF, JUN, CREB1, ATF2, RARA, RFWD2, POU2F1, RELA, FOS, ETS1
MPO	YES	2	SP1, RUNX1
APP	YES	8	SP1, CTCF, TBP, NFIL3, TFAP2A, JUN, ETS2, HDAC9
PSEN1	YES	3	SP1, CREB1, ELK1
BLMH	YES	2	SP1, MZF1
PSEN2	YES	1	EGR1
A2M	YES	3	TFCP2, NFKB1, STAT3

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SORL1	NOS3	No	1	APP
SORL1	APP	Yes	5	COPS5, GGA2, AURKA, APP, GGA1
SORL1	PSEN1	No	1	APP
SORL1	APBB2	No	2	WISP3, APP
SORL1	PAXIP1	No	1	APP
SORL1	BLMH	No	2	COPS5, APP
SORL1	PSEN2	No	1	APP
SORL1	A2M	No	3	CFTR, FBXO6, APP
NOS3	ACE	No	1	ACTB
NOS3	PLAU	No	1	ELAVL1
NOS3	APP	Yes	16	MAST1, GUCY1B3, NOS3, RNF32, EXOC6, CDC37, PI4K2A, PSEN1, HSP90AA1, A2M, CAV1, PAXIP1, AKT1, PSEN2, EXOSC1, APP
NOS3	PSEN1	Yes	11	NOS3, RNF32, APOE, CDC37, GCDH, PSEN1, APP, ST13, UMPS, PSEN2, KANK2
NOS3	APBB2	No	1	APP
NOS3	PAXIP1	Yes	8	MAST1, NOS3, UMPS, ELAVL1, TECR, RNF32, A2M, APP
NOS3	BLMH	No	3	MAST1, RNF32, APP
NOS3	PSEN2	Yes	10	MAST1, NOS3, EXOC6, GCDH, PSEN1, ELAVL1, RNF32, PSEN2, CEP55, APP
NOS3	A2M	Yes	14	MAST1, NOS3, GCDH, RNF32, APOE, CDC37, EXOSC1, ELAVL3, ACTB, PAXIP1, UMPS, A2M, FIS1, APP
ACE	APP	No	1	CSNK2A1
ACE	PAXIP1	No	1	CSNK2A1
ACE	A2M	No	1	ACTB
PLAU	APP	No	4	BTK, MYC, SERPINB2, LRP2
PLAU	PAXIP1	No	2	SCAMP5, ELAVL1
PLAU	PSEN2	No	1	ELAVL1
APP	PSEN1	Yes	30	GSAP, KCNIP4, CTNND1, RNF32, ECSIT, CDK5, CTNNA1, NOS3, MAPT, PSMA5, UBQLN1, APP, CTNNB1, PRDX2, GAPDH, CLSTN1, NCSTN, NOTCH1, PSEN1, GFAP, TRAF6, GSK3B, CFL1, FGF13, AP1M2, CDC37, PRAM1, RAB3A, PSEN2, HERPUD1
APP	APBB2	Yes	7	AKAP1, HSPA8, MRPL1, SYNCRIP, EGFR, APBB1, APP
APP	PAXIP1	Yes	54	TCN2, FUCA1, DDX18, TARDBP, S100A8, NOL7, PCYT1B, RNF32, A2M, ECSIT, KIF2C, LIMA1, LGALS3, APP, CLU, RPS27A, FEN1, SRRM2, SSB, GPKOW, MAPRE2, SKA3, SRSF1, RPL12, SH3GL2, PPP1CC, CDC20, ERH, MAST1, SRSF9, SNRNP70, STOML2, RNMTL1, G3BP1, NOS3, HP1BP3, ZNF622, LARP7, SRPK1, LUC7L2, C7ORF50, RPS20, CSNK2A1, PGM1, STAU1, PPIA, PLCD1, PPP2R5C, PPHLN1, PAGR1, CIRBP, PPARG, WDR5, EIF2S2
APP	BLMH	Yes	20	MAST1, BLMH, ECSIT, AP1M2, MAPK8, GORASP2, MCM2, CUL4B, PES1, SYNCRIP, PDPK1, MAPRE1, LIMK1, ATL3, RNF32, RPL11, COPS5, UBE2I, G3BP1, APP
APP	PSEN2	Yes	23	PPP5C, APBA2, CHKA, RNF32, APP, NOS3, TSPAN5, UBQLN1, KCNIP4, MAST1, ECSIT, IFIT3, DNAJB1, SPC24, EXOC6, NCSTN, GFAP, PSEN1, TRAF6, FHL2, APBA3, PSEN2, APBA1
APP	HFE	No	1	SYVN1
APP	A2M	Yes	26	EXOSC1, LRP1, PAXIP1, PRAM1, RNF32, A2M, ECSIT, CDK7, RAP1B, APP, NOS3, TNFRSF14, DNAJB1, IL1B, TGM2, TK1, TGIF1, MAST1, CDKN1A, PRDX2, PAEP, AP1M2, CDC37, RAB3A, IFIT3, CDK2AP2
PSEN1	APBB2	No	1	APP
PSEN1	PAXIP1	No	7	NOS3, ECSIT, RNF32, APP, UMPS, PKP4, EPB41L3
PSEN1	BLMH	No	5	ECSIT, APP, RNF32, CYP2C8, AP1M2
PSEN1	PSEN2	Yes	23	BCL2L1, FBXL12, PDCD4, KCNIP4, RNF32, APP, GCDH, KCNIP3, UBQLN1, RHEB, FLNB, APH1B, ECSIT, APH1A, NCSTN, NOS3, TRAF6, GFAP, PSEN1, ICAM5, PSENEN, PSEN2, CIB1
PSEN1	A2M	No	19	CYP2C18, FBXL12, NOS3, GCDH, PRDX2, RNF32, AP1M2, RAD23A, CDC37, PRAM1, STAMBPL1, RAB3A, APP, UMPS, APOE, ECSIT, TUBA1B, RHEB, CYP2C8
APBB2	PAXIP1	No	1	APP
APBB2	BLMH	No	3	SYNCRIP, SORT1, APP
APBB2	PSEN2	No	1	APP
APBB2	A2M	No	1	APP
PAXIP1	BLMH	No	5	MAST1, G3BP1, ECSIT, RNF32, APP
PAXIP1	PSEN2	No	8	MAST1, NOS3, ECSIT, AAMP, ELAVL1, MGEA5, RNF32, APP
PAXIP1	A2M	Yes	9	MAST1, NOS3, ECSIT, RNF32, MGEA5, UMPS, A2M, H2AFX, APP
BLMH	PSEN2	No	4	MAST1, ECSIT, RNF32, APP
BLMH	A2M	No	6	MAST1, ECSIT, AP1M2, CYP2C8, RNF32, APP
PSEN2	A2M	No	13	MAST1, NOS3, GCDH, ECSIT, FBXL12, IFIT5, DNAJB1, EVI5L, RNF32, MGEA5, IFIT3, RHEB, APP
HFE	A2M	No	1	B2M

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PSEN1	A2M	No	1	KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
SORL1	NOS3	No	-	1	BDNF
SORL1	PLAU	No	-	1	PLAUR
SORL1	APP	Yes	activation, binding	1	BACE1
SORL1	PSEN1	No	-	3	BACE1, BDNF, APP
SORL1	APBB2	No	-	1	APP
SORL1	BLMH	No	-	1	APP
SORL1	A2M	No	-	1	APP
NOS3	ACE	Yes	expression, activation, binding	1	BDKRB2
NOS3	PLAU	No	-	5	SRC, FOSL1, JUN, MMP9, ATF2
NOS3	APP	No	-	26	EDNRB, EDNRA, APLN, GNG2, OXT, TP53, AVP, KNG1, GNAI1, GCG, CXCL12, IL6, BDKRB2, AGTR1, TGFB1, GNB1, CNR1, HSP90AB1, VEGFA, EDN1, STAT3, GNRH1, GNAI3, CALR, IGF1, PTGER3
NOS3	PSEN1	No	-	7	BDNF, DDIT3, CREB1, TP53, SRC, LEP, PRKACA
NOS3	PAXIP1	No	-	1	TP53
NOS3	PSEN2	No	-	1	ESR1
NOS3	A2M	No	-	13	STAT3, RHOA, PTPN11, IL10, MMP2, IGF1, TGFB1, GAB1, PDGFB, LEP, VEGFA, KNG1, RAC3
ACE	APP	No	-	2	AGT, BDKRB2
ACE	PSEN1	No	-	1	MDK
PLAU	APP	No	-	10	FGA, LRP1, RELA, MAPK1, PLG, MAPK3, FN1, SERPINE1, NFKB1, HRG
PLAU	PSEN1	No	-	1	SRC
PLAU	A2M	No	-	6	LRP1, F2, FN1, SERPINE1, PLG, HRG
APP	PSEN1	Yes	activation, binding	10	NOTCH1, APBA2, NCAM1, NCSTN, MAPK8, TP53, UBQLN1, BACE1, UBC, GSK3B
APP	APBB2	Yes	binding	0
APP	PAXIP1	No	-	1	TP53
APP	BLMH	Yes	binding	2	UBC, UBB
APP	PSEN2	No	-	6	NOTCH1, NGFR, NCSTN, PSEN1, UBQLN1, UBC
APP	HFE	No	-	1	B2M
APP	A2M	Yes	binding	39	PF4, FN1, LEFTY2, FIGF, LRP1, ALB, SERPINE1, APOA1, KNG1, ACTN4, SRGN, ACTN1, SPARC, PROS1, CLU, ALDOA, TGFB1, F5, PPBP, MMRN1, TGFB2, PLG, VWF, F13A1, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, STAT3, TMSB4X, TGFB3, IGF2, IGF1, EGF, VEGFC, HRG, SERPINF2
PSEN1	APBB2	No	-	1	APP
PSEN1	PAXIP1	No	-	1	TP53
PSEN1	BLMH	No	-	2	UBC, APP
PSEN1	PSEN2	Yes	activation, binding	24	BCL2L1, EIF2AK3, KCNIP4, FLNC, DLL1, SRI, NOTCH3, NOTCH4, UBQLN1, KCNIP3, METTL2B, DNER, ATF6, APH1B, RYR2, NCSTN, ICAM5, TRAF6, MTCH1, NOTCH1, FLNB, PSENEN, UBC, ERN1
PSEN1	A2M	No	-	3	LEP, GRB2, APP
APBB2	BLMH	No	-	1	APP
APBB2	A2M	No	-	1	APP
BLMH	PSEN2	No	-	1	UBC
BLMH	A2M	No	-	1	APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
APP	A2M	No	-	1	LRP1
PSEN1	PSEN2	No	-	4	APH1B, NCSTN, APH1A, PSENEN

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
ACE	APP	Yes	2	ACE, APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Alzheimer's disease	hsa05010	5.34	3	PSEN2, APP, PSEN1
Notch signaling pathway	hsa04330	7.12	2	PSEN2, PSEN1
Neurotrophin signaling pathway	hsa04722	5.78	2	PSEN2, PSEN1
Complement and coagulation cascades	hsa04610	6.58	2	A2M, PLAU
Transcriptional misregulation in cancer	hsa05202	5.21	2	MPO, PLAU

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Immune diseases	NEW	4.47	0.007	MPO, NOS3, PSEN1, ACE, A2M, APP
Renin-angiotensin system (hsa04614)	NEW	8.68	0.002	NOS3, ACE, APP
Cancers: Overview	NEW	2.72	0.013	MPO, NOS3, HFE, PLAU, PSEN1, APP, PAXIP1, A2M, ACE
Infectious diseases: Parasitic	NEW	4.46	0.009	NOS3, PLAU, PSEN1, ACE, A2M, APP
Complement and coagulation cascades (hsa04610)	-	6.58	0.047	A2M, PLAU, APP
Salmonella infection (hsa05132)	NEW	6.29	0.007	NOS3, PLAU, PSEN1, APP
Inflammatory bowel disease (IBD) (hsa05321)	NEW	6.43	0.002	A2M, NOS3, PSEN1, APP
Transcriptional misregulation in cancer (hsa05202)	-	5.21	0.02	MPO, NOS3, PLAU, PSEN1, APP
Digestive system	NEW	4.12	0.043	NOS3, PLAU, PSEN1, A2M, PSEN2, APP
Immune system	NEW	2.92	0.034	MPO, NOS3, PLAU, PSEN1, ACE, HFE, A2M, APP
MAPK signaling pathway (hsa04010)	NEW	4.63	0.002	NOS3, PLAU, PSEN1, ACE, A2M, APP
Neurotrophin signaling pathway (hsa04722)	-	5.78	0.017	PSEN2, NOS3, APP, PSEN1
Alzheimer's disease (hsa05010)	-	5.34	0.031	PSEN2, NOS3, APP, PSEN1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Hemostasis	R-HSA-109582	3.98	4	A2M, NOS3, PLAU, APP
Signal Transduction	R-HSA-162582	1.78	4	PSEN2, A2M, NOS3, APP
Extracellular matrix organization	R-HSA-1474244	4.91	3	A2M, PSEN1, APP
Disease	R-HSA-1643685	3.33	3	PSEN2, NOS3, APP
Platelet degranulation	R-HSA-114608	6.68	2	A2M, APP
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	A2M, APP
Immune System	R-HSA-168256	2.37	2	BLMH, APP
Degradation of the extracellular matrix	R-HSA-1474228	6.11	2	A2M, PSEN1
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	2	A2M, APP
Metabolism	R-HSA-1430728	2.34	2	A2M, NOS3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
PPARA activates gene expression (R-HSA-1989781)	NEW	6.18	0.033	NOS3, PAXIP1, ACE, APP
Signalling by NGF (R-HSA-166520)	NEW	4.23	0.009	NOS3, PLAU, BLMH, PSEN1, APP, PSEN2, ACE
Platelet activation, signaling and aggregation (R-HSA-76002)	-	5.15	0.047	MPO, A2M, NOS3, PLAU, APP
Degradation of the extracellular matrix (R-HSA-1474228)	-	6.11	0.039	PSEN2, A2M, PSEN1, APP
Extracellular matrix organization (R-HSA-1474244)	-	4.91	0.0	NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
Signaling by ERBB4 (R-HSA-1236394)	NEW	4.7	0.011	NOS3, PLAU, PSEN1, ACE, PSEN2, APP
Axon guidance (R-HSA-422475)	NEW	3.93	0.029	NOS3, PLAU, BLMH, PSEN1, ACE, PSEN2, APP
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (R-HSA-400206)	NEW	6.14	0.037	NOS3, PAXIP1, ACE, APP

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	13	MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
protein binding (GO:0005515)	0.46	12	NOS3, APP, SORL1, BLMH, PSEN1, A2M, APBB2, PAXIP1, HFE, PSEN2, PLAU, ACE
catalytic activity (GO:0003824)	1.05	7	MPO, NOS3, PLAU, BLMH, PSEN1, PSEN2, ACE
hydrolase activity (GO:0016787)	1.9	5	PSEN2, PLAU, BLMH, ACE, PSEN1
peptidase activity (GO:0008233)	3.23	5	PSEN2, BLMH, PLAU, PSEN1, ACE
endopeptidase activity (GO:0004175)	3.63	5	PSEN2, ACE, PLAU, BLMH, PSEN1
peptidase activity, acting on L-amino acid peptides (GO:0070011)	3.26	5	PSEN2, PLAU, BLMH, ACE, PSEN1
cation binding (GO:0043169)	1.4	4	MPO, NOS3, ACE, APP
receptor binding (GO:0005102)	2.43	4	A2M, ACE, HFE, APP
metal ion binding (GO:0046872)	1.41	4	MPO, NOS3, ACE, APP
enzyme binding (GO:0019899)	2.27	4	A2M, SORL1, ACE, APP
ion binding (GO:0043167)	1.36	4	MPO, NOS3, ACE, APP
peptide binding (GO:0042277)	4.22	3	SORL1, APBB2, HFE
transition metal ion binding (GO:0046914)	2.48	3	NOS3, ACE, APP
carbohydrate derivative binding (GO:0097367)	2.03	3	MPO, NOS3, APP
organic cyclic compound binding (GO:0097159)	1.05	3	MPO, NOS3, APP
amide binding (GO:0033218)	4.14	3	SORL1, APBB2, HFE
heterocyclic compound binding (GO:1901363)	1.06	3	MPO, NOS3, APP
peptidase inhibitor activity (GO:0030414)	4.55	2	A2M, APP
exopeptidase activity (GO:0008238)	5.07	2	BLMH, ACE
macromolecular complex binding (GO:0044877)	2.61	2	MPO, SORL1
enzyme activator activity (GO:0008047)	3.56	2	A2M, APP
enzyme inhibitor activity (GO:0004857)	3.78	2	A2M, APP
molecular function regulator (GO:0098772)	2.51	2	A2M, APP
serine-type peptidase activity (GO:0008236)	4.27	2	PLAU, ACE
sulfur compound binding (GO:1901681)	4.32	2	MPO, APP
aspartic-type peptidase activity (GO:0070001)	6.1	2	PSEN2, PSEN1
beta-amyloid binding (GO:0001540)	6.21	2	SORL1, APBB2
carboxypeptidase activity (GO:0004180)	6.0	2	BLMH, ACE
actin binding (GO:0003779)	3.74	2	NOS3, ACE
oxidoreductase activity (GO:0016491)	3.12	2	MPO, NOS3
endopeptidase regulator activity (GO:0061135)	4.57	2	A2M, APP
anion binding (GO:0043168)	4.17	2	NOS3, ACE
heme binding (GO:0020037)	4.86	2	MPO, NOS3
serine hydrolase activity (GO:0017171)	4.26	2	PLAU, ACE
enzyme regulator activity (GO:0030234)	2.85	2	A2M, APP
peptidase regulator activity (GO:0061134)	4.37	2	A2M, APP
protein domain specific binding (GO:0019904)	3.32	2	PSEN1, APP
endopeptidase inhibitor activity (GO:0004866)	4.6	2	A2M, APP
serine-type endopeptidase inhibitor activity (GO:0004867)	5.16	2	A2M, APP
heparin binding (GO:0008201)	4.68	2	MPO, APP
cytoskeletal protein binding (GO:0008092)	3.02	2	NOS3, ACE
tetrapyrrole binding (GO:0046906)	4.8	2	MPO, NOS3
glycosaminoglycan binding (GO:0005539)	4.42	2	MPO, APP
aspartic-type endopeptidase activity (GO:0004190)	6.13	2	PSEN2, PSEN1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
serine-type endopeptidase activity (GO:0004252)	NEW	4.4	0.003	A2M, NOS3, PLAU, HFE, APP
endopeptidase activity (GO:0004175)	-	3.63	0.0	NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP
C-X-C chemokine binding (GO:0019958)	NEW	7.79	0.005	A2M, APP
interleukin-8 binding (GO:0019959)	NEW	8.64	0.001	A2M, APP
chemokine binding (GO:0019956)	NEW	6.69	0.038	A2M, APP
cytokine binding (GO:0019955)	NEW	5.21	0.005	MPO, A2M, NOS3, APP
enzyme binding (GO:0019899)	-	2.27	0.012	NOS3, SORL1, BLMH, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
drug binding (GO:0008144)	NEW	5.03	0.016	NOS3, PLAU, ACE, APP
exopeptidase activity (GO:0008238)	-	5.07	0.009	A2M, BLMH, ACE, APP
peptidase activity (GO:0008233)	-	3.23	0.0	NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP
serine-type peptidase activity (GO:0008236)	-	4.27	0.006	A2M, NOS3, PLAU, HFE, APP
sulfur compound binding (GO:1901681)	-	4.32	0.001	MPO, NOS3, PLAU, ACE, A2M, APP
beta-amyloid binding (GO:0001540)	-	6.21	0.027	APBB2, SORL1, APP, PSEN1
carboxypeptidase activity (GO:0004180)	-	6.0	0.009	BLMH, ACE, APP
growth factor binding (GO:0019838)	NEW	4.89	0.022	A2M, NOS3, PLAU, APP
protease binding (GO:0002020)	NEW	5.08	0.004	A2M, PLAU, PSEN1, APP
peptidyl-dipeptidase activity (GO:0008241)	NEW	8.35	0.003	NOS3, ACE
serine hydrolase activity (GO:0017171)	-	4.26	0.007	A2M, NOS3, PLAU, HFE, APP
amide binding (GO:0033218)	-	4.14	0.022	APBB2, SORL1, PSEN1, HFE, APP
peptide binding (GO:0042277)	-	4.22	0.021	APBB2, SORL1, PSEN1, HFE, APP
heparin binding (GO:0008201)	-	4.68	0.0	MPO, NOS3, PLAU, ACE, A2M, APP
glycosaminoglycan binding (GO:0005539)	-	4.42	0.001	MPO, NOS3, PLAU, ACE, A2M, APP
peptidase activity, acting on L-amino acid peptides (GO:0070011)	-	3.26	0.011	NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	13	MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
biological regulation (GO:0065007)	0.39	12	MPO, NOS3, SORL1, PSEN1, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
regulation of biological process (GO:0050789)	0.45	12	MPO, NOS3, HFE, SORL1, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
metabolic process (GO:0008152)	0.58	12	MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
regulation of cellular process (GO:0050794)	0.5	12	MPO, NOS3, HFE, SORL1, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
negative regulation of biological process (GO:0048519)	1.33	11	MPO, NOS3, SORL1, PSEN1, A2M, APBB2, APP, HFE, PSEN2, PLAU, ACE
single-organism cellular process (GO:0044763)	0.65	11	MPO, NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
single-organism process (GO:0044699)	0.48	11	MPO, NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
organic substance metabolic process (GO:0071704)	0.63	11	MPO, NOS3, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
primary metabolic process (GO:0044238)	0.69	10	NOS3, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
regulation of metabolic process (GO:0019222)	1.02	10	NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
response to stimulus (GO:0050896)	1.22	10	MPO, NOS3, PLAU, BLMH, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
regulation of cellular metabolic process (GO:0031323)	1.07	10	NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
positive regulation of biological process (GO:0048518)	1.2	10	NOS3, SORL1, APP, PSEN1, APBB2, PAXIP1, HFE, PSEN2, PLAU, ACE
negative regulation of cellular process (GO:0048523)	1.41	10	MPO, NOS3, SORL1, PSEN1, A2M, APBB2, APP, HFE, PSEN2, ACE
positive regulation of cellular process (GO:0048522)	1.3	10	NOS3, SORL1, APP, PSEN1, APBB2, PAXIP1, HFE, PSEN2, PLAU, ACE
regulation of primary metabolic process (GO:0080090)	1.08	9	NOS3, HFE, SORL1, PSEN1, APBB2, APP, PAXIP1, A2M, ACE
protein metabolic process (GO:0019538)	1.45	9	BLMH, SORL1, PSEN1, PAXIP1, A2M, ACE, PSEN2, PLAU, APP
cellular metabolic process (GO:0044237)	0.69	9	MPO, NOS3, PLAU, BLMH, PAXIP1, APP, PSEN1, PSEN2, ACE
macromolecule metabolic process (GO:0043170)	0.83	9	BLMH, SORL1, PSEN1, A2M, ACE, PAXIP1, PSEN2, PLAU, APP
signal transduction (GO:0007165)	1.28	9	NOS3, SORL1, PAXIP1, APBB2, PSEN1, HFE, PSEN2, PLAU, APP
regulation of molecular function (GO:0065009)	1.78	9	NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
developmental process (GO:0032502)	1.36	8	MPO, NOS3, PLAU, PAXIP1, APP, PSEN1, HFE, ACE
positive regulation of metabolic process (GO:0009893)	1.74	8	NOS3, SORL1, PAXIP1, APP, PSEN1, HFE, PLAU, ACE
regulation of macromolecule metabolic process (GO:0060255)	1.08	8	HFE, SORL1, PAXIP1, APBB2, PSEN1, ACE, A2M, APP
positive regulation of molecular function (GO:0044093)	2.23	8	NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
regulation of response to stimulus (GO:0048583)	1.54	8	NOS3, SORL1, PAXIP1, PSEN1, HFE, A2M, PLAU, APP
cellular component organization (GO:0016043)	1.24	8	MPO, NOS3, PAXIP1, APBB2, PSEN1, HFE, A2M, APP
single-organism developmental process (GO:0044767)	1.49	8	MPO, NOS3, PLAU, PAXIP1, APP, PSEN1, HFE, ACE
response to stress (GO:0006950)	1.8	8	MPO, NOS3, PLAU, PAXIP1, PSEN1, HFE, PSEN2, APP
regulation of multicellular organismal process (GO:0051239)	1.87	8	NOS3, SORL1, PSEN1, PAXIP1, APP, HFE, PLAU, ACE
cellular component organization or biogenesis (GO:0071840)	1.22	8	MPO, NOS3, PAXIP1, APBB2, PSEN1, HFE, A2M, APP
establishment of localization (GO:0051234)	1.48	7	SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
single-multicellular organism process (GO:0044707)	1.78	7	MPO, NOS3, PLAU, PSEN1, ACE, HFE, APP
regulation of catalytic activity (GO:0050790)	1.97	7	NOS3, SORL1, PSEN1, A2M, APP, PSEN2, ACE
regulation of developmental process (GO:0050793)	2.1	7	NOS3, SORL1, PAXIP1, APP, PSEN1, PLAU, ACE
positive regulation of cellular metabolic process (GO:0031325)	1.81	7	NOS3, PLAU, PSEN1, PAXIP1, ACE, HFE, APP
anatomical structure development (GO:0048856)	1.58	7	NOS3, PLAU, PSEN1, PAXIP1, ACE, HFE, APP
regulation of protein metabolic process (GO:0051246)	1.93	7	SORL1, PAXIP1, APP, PSEN1, HFE, A2M, ACE
regulation of cellular protein metabolic process (GO:0032268)	1.99	7	SORL1, PSEN1, PAXIP1, ACE, HFE, A2M, APP
regulation of signal transduction (GO:0009966)	1.84	7	NOS3, SORL1, PSEN1, HFE, A2M, PLAU, APP
regulation of biological quality (GO:0065008)	1.68	7	NOS3, SORL1, PSEN1, APP, HFE, PLAU, ACE
multicellular organismal process (GO:0032501)	1.45	7	MPO, NOS3, PLAU, PSEN1, APP, HFE, ACE
regulation of multicellular organismal development (GO:2000026)	2.31	7	NOS3, SORL1, PAXIP1, APP, PSEN1, PLAU, ACE
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	7	NOS3, SORL1, PAXIP1, APBB2, PSEN1, HFE, APP
transport (GO:0006810)	1.51	7	SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
regulation of signaling (GO:0023051)	1.72	7	NOS3, SORL1, PSEN1, HFE, A2M, PLAU, APP
regulation of cell communication (GO:0010646)	1.73	7	NOS3, SORL1, PSEN1, HFE, A2M, PLAU, APP
localization (GO:0051179)	1.4	7	SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
positive regulation of catalytic activity (GO:0043085)	2.4	7	NOS3, SORL1, PSEN1, A2M, APP, PSEN2, ACE
response to abiotic stimulus (GO:0009628)	2.8	6	MPO, NOS3, PLAU, PAXIP1, PSEN2, APP
single-organism metabolic process (GO:0044710)	1.63	6	MPO, NOS3, SORL1, PSEN1, APP, ACE
regulation of cell death (GO:0010941)	2.43	6	MPO, NOS3, SORL1, PSEN1, APBB2, PSEN2
regulation of phosphate metabolic process (GO:0019220)	2.35	6	NOS3, SORL1, PSEN1, APP, HFE, ACE
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	6	HFE, SORL1, PAXIP1, PSEN1, ACE, APP
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	6	NOS3, PAXIP1, APBB2, PSEN1, HFE, APP
negative regulation of cell death (GO:0060548)	2.95	6	MPO, NOS3, SORL1, PSEN1, APBB2, PSEN2
negative regulation of response to stimulus (GO:0048585)	2.52	6	NOS3, SORL1, PSEN1, HFE, A2M, PLAU
negative regulation of multicellular organismal process (GO:0051241)	2.84	6	NOS3, SORL1, PSEN1, HFE, PLAU, APP
regulation of biosynthetic process (GO:0009889)	1.37	6	NOS3, PSEN1, APBB2, PAXIP1, HFE, APP
positive regulation of protein metabolic process (GO:0051247)	2.43	6	HFE, SORL1, PAXIP1, PSEN1, ACE, APP
regulation of cellular biosynthetic process (GO:0031326)	1.38	6	NOS3, PAXIP1, APBB2, PSEN1, HFE, APP
regulation of cellular component organization (GO:0051128)	2.01	6	SORL1, PAXIP1, APBB2, PSEN1, HFE, ACE
regulation of phosphorus metabolic process (GO:0051174)	2.35	6	NOS3, SORL1, PSEN1, ACE, HFE, APP
regulation of protein modification process (GO:0031399)	2.32	6	HFE, SORL1, PSEN1, PAXIP1, ACE, APP
cellular nitrogen compound metabolic process (GO:0034641)	1.22	6	NOS3, PAXIP1, APP, PSEN1, PSEN2, ACE
nitrogen compound metabolic process (GO:0006807)	1.13	6	NOS3, PAXIP1, APP, PSEN1, PSEN2, ACE
negative regulation of molecular function (GO:0044092)	2.74	6	NOS3, SORL1, PSEN1, HFE, A2M, APP
movement of cell or subcellular component (GO:0006928)	2.61	6	NOS3, PLAU, PAXIP1, APBB2, PSEN1, APP
regulation of gene expression (GO:0010468)	1.37	6	PAXIP1, APBB2, PSEN1, HFE, A2M, APP
negative regulation of metabolic process (GO:0009892)	1.93	5	A2M, SORL1, HFE, PSEN1, APP
negative regulation of cellular metabolic process (GO:0031324)	2.01	5	A2M, SORL1, PSEN1, APP, HFE
homeostatic process (GO:0042592)	2.61	5	NOS3, PLAU, HFE, PSEN1, APP
cell surface receptor signaling pathway (GO:0007166)	2.09	5	PSEN2, NOS3, HFE, PSEN1, APP
intracellular signal transduction (GO:0035556)	2.39	5	PSEN2, NOS3, PAXIP1, APBB2, PSEN1
regulation of apoptotic process (GO:0042981)	2.5	5	PSEN2, MPO, NOS3, APBB2, PSEN1
negative regulation of catalytic activity (GO:0043086)	3.0	5	A2M, SORL1, NOS3, PSEN1, APP
cellular protein metabolic process (GO:0044267)	1.63	5	PSEN2, BLMH, PAXIP1, PSEN1, APP
cellular response to stimulus (GO:0051716)	1.97	5	APP, PLAU, PAXIP1, HFE, PSEN1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	5	A2M, SORL1, PSEN1, APP, HFE
cellular macromolecule metabolic process (GO:0044260)	0.93	5	PSEN2, BLMH, PAXIP1, PSEN1, APP
cellular developmental process (GO:0048869)	1.82	5	A2M, ACE, PAXIP1, PSEN1, APP
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	5	APBB2, APP, PAXIP1, HFE, PSEN1
regulation of programmed cell death (GO:0043067)	2.49	5	PSEN2, MPO, NOS3, APBB2, PSEN1
negative regulation of apoptotic process (GO:0043066)	3.04	5	PSEN2, MPO, NOS3, APBB2, PSEN1
regulation of immune system process (GO:0002682)	2.5	5	A2M, ACE, PAXIP1, HFE, PSEN1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	5	ACE, APP, PAXIP1, HFE, PSEN1
cell migration (GO:0016477)	3.12	5	APBB2, NOS3, PAXIP1, PLAU, PSEN1
negative regulation of programmed cell death (GO:0043069)	3.02	5	PSEN2, MPO, NOS3, APBB2, PSEN1
cellular homeostasis (GO:0019725)	3.23	5	NOS3, PLAU, HFE, PSEN1, APP
locomotion (GO:0040011)	2.91	5	NOS3, PLAU, PAXIP1, APBB2, PSEN1
negative regulation of protein metabolic process (GO:0051248)	2.82	5	A2M, SORL1, PSEN1, HFE, APP
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	5	PAXIP1, APBB2, PSEN1, HFE, APP
reproductive process (GO:0022414)	2.55	5	ACE, NOS3, PLAU, HFE, APP
regulation of proteolysis (GO:0030162)	3.2	5	A2M, SORL1, PSEN1, APP, HFE
regulation of RNA biosynthetic process (GO:2001141)	1.55	5	PAXIP1, APBB2, PSEN1, HFE, APP
response to chemical (GO:0042221)	1.98	5	MPO, BLMH, PLAU, HFE, APP
regulation of localization (GO:0032879)	1.94	5	ACE, SORL1, PLAU, NOS3, HFE
proteolysis (GO:0006508)	2.73	5	PSEN2, ACE, PLAU, BLMH, PSEN1
regulation of phosphorylation (GO:0042325)	2.5	5	ACE, SORL1, HFE, PSEN1, APP
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	5	A2M, SORL1, PSEN1, APP, HFE
cell motility (GO:0048870)	3.02	5	APBB2, NOS3, PAXIP1, PLAU, PSEN1
regulation of RNA metabolic process (GO:0051252)	1.52	5	APBB2, APP, PAXIP1, HFE, PSEN1
immune system process (GO:0002376)	2.29	5	MPO, ACE, APP, HFE, PSEN1
regulation of transcription, DNA-templated (GO:0006355)	1.56	5	PAXIP1, APBB2, PSEN1, HFE, APP
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	5	PAXIP1, APBB2, PSEN1, HFE, APP
negative regulation of proteolysis (GO:0045861)	3.98	5	A2M, SORL1, PSEN1, APP, HFE
regulation of protein phosphorylation (GO:0001932)	2.57	5	ACE, SORL1, HFE, PSEN1, APP
regulation of binding (GO:0051098)	4.08	4	SORL1, PSEN1, HFE, APP
positive regulation of biosynthetic process (GO:0009891)	2.29	4	NOS3, PAXIP1, APP, PSEN1
cell differentiation (GO:0030154)	2.14	4	A2M, PAXIP1, ACE, PSEN1
positive regulation of gene expression (GO:0010628)	2.35	4	PAXIP1, PSEN1, HFE, APP
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	4	NOS3, PAXIP1, PSEN1, APP
small molecule metabolic process (GO:0044281)	2.38	4	MPO, SORL1, NOS3, APP
negative regulation of hydrolase activity (GO:0051346)	3.74	4	A2M, SORL1, NOS3, APP
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	4	ACE, NOS3, HFE, PSEN1
regulation of kinase activity (GO:0043549)	3.07	4	ACE, SORL1, APP, PSEN1
animal organ development (GO:0048513)	2.53	4	ACE, NOS3, HFE, PSEN1
regulation of receptor activity (GO:0010469)	4.98	4	APP, PLAU, HFE, PSEN1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	4	NOS3, PAXIP1, APP, PSEN1
multicellular organismal reproductive process (GO:0048609)	3.35	4	NOS3, PLAU, ACE, APP
positive regulation of phosphate metabolic process (GO:0045937)	2.78	4	ACE, NOS3, HFE, PSEN1
ion transport (GO:0006811)	2.66	4	PSEN2, ACE, HFE, PSEN1
regulation of protein kinase activity (GO:0045859)	3.15	4	ACE, SORL1, APP, PSEN1
cellular protein modification process (GO:0006464)	1.79	4	BLMH, PAXIP1, PSEN1, APP
biosynthetic process (GO:0009058)	1.32	4	MPO, NOS3, PAXIP1, HFE
single-organism transport (GO:0044765)	2.18	4	A2M, SORL1, ACE, APP
protein modification process (GO:0036211)	1.79	4	BLMH, PAXIP1, PSEN1, APP
regulation of protein binding (GO:0043393)	4.6	4	SORL1, PSEN1, HFE, APP
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	NOS3, PAXIP1, PSEN1, APP
cellular chemical homeostasis (GO:0055082)	3.4	4	APP, PLAU, HFE, PSEN1
single-organism localization (GO:1902578)	2.09	4	A2M, SORL1, ACE, APP
system process (GO:0003008)	2.3	4	ACE, NOS3, PSEN1, APP
regulation of hydrolase activity (GO:0051336)	2.53	4	A2M, SORL1, NOS3, APP
regulation of immune response (GO:0050776)	2.98	4	A2M, PAXIP1, HFE, PSEN1
organonitrogen compound metabolic process (GO:1901564)	2.32	4	PSEN2, NOS3, ACE, PSEN1
protein maturation (GO:0051604)	4.48	4	PSEN2, SORL1, ACE, PSEN1
response to external stimulus (GO:0009605)	2.55	4	MPO, PLAU, HFE, APP
positive regulation of protein modification process (GO:0031401)	2.7	4	ACE, PAXIP1, HFE, PSEN1
macromolecule modification (GO:0043412)	1.73	4	BLMH, PAXIP1, PSEN1, APP
regulation of transferase activity (GO:0051338)	2.88	4	ACE, SORL1, APP, PSEN1
chemical homeostasis (GO:0048878)	2.97	4	APP, PLAU, HFE, PSEN1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	4	PAXIP1, PSEN1, HFE, APP
cellular response to stress (GO:0033554)	2.51	4	PLAU, PAXIP1, HFE, PSEN1
positive regulation of multicellular organismal process (GO:0051240)	2.49	4	NOS3, PAXIP1, PLAU, PSEN1
regulation of transport (GO:0051049)	2.24	3	SORL1, NOS3, HFE
positive regulation of response to stimulus (GO:0048584)	2.18	3	PAXIP1, HFE, PSEN1
cation homeostasis (GO:0055080)	3.46	3	APP, HFE, PSEN1
inorganic ion homeostasis (GO:0098771)	3.43	3	PSEN1, HFE, APP
organic cyclic compound metabolic process (GO:1901360)	1.26	3	SORL1, PAXIP1, APP
Notch signaling pathway (GO:0007219)	4.99	3	PSEN2, APP, PSEN1
response to external biotic stimulus (GO:0043207)	3.13	3	MPO, PLAU, APP
negative regulation of cell development (GO:0010721)	4.02	3	SORL1, APP, PSEN1
regulation of cell proliferation (GO:0042127)	2.41	3	NOS3, PLAU, ACE
organic substance transport (GO:0071702)	2.15	3	SORL1, ACE, PSEN1
response to organic substance (GO:0010033)	2.2	3	MPO, PLAU, APP
multi-organism process (GO:0051704)	2.65	3	MPO, HFE, APP
positive regulation of phosphorylation (GO:0042327)	2.9	3	ACE, HFE, PSEN1
single organism reproductive process (GO:0044702)	2.73	3	NOS3, PLAU, ACE
response to biotic stimulus (GO:0009607)	3.09	3	MPO, PLAU, APP
vesicle-mediated transport (GO:0016192)	2.72	3	A2M, SORL1, APP
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	3	ACE, APP, PSEN1
extracellular matrix organization (GO:0030198)	4.01	3	A2M, APBB2, APP
negative regulation of cell communication (GO:0010648)	2.66	3	SORL1, NOS3, PSEN1
regulation of catabolic process (GO:0009894)	3.52	3	SORL1, HFE, PSEN1
cellular component assembly (GO:0022607)	2.14	3	PSEN1, HFE, APP
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	NOS3, PLAU, PSEN1
positive regulation of transferase activity (GO:0051347)	3.31	3	SORL1, ACE, PSEN1
neuron death (GO:0070997)	5.86	3	PLAU, APP, PSEN1
regulation of protein tyrosine kinase activity (GO:0061097)	5.59	3	ACE, PSEN1, APP
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	3	NOS3, PLAU, PSEN1
positive regulation of cellular component organization (GO:0051130)	2.68	3	PAXIP1, HFE, PSEN1
cation transport (GO:0006812)	3.11	3	PSEN2, HFE, PSEN1
defense response (GO:0006952)	2.78	3	MPO, HFE, APP
regulation of intracellular signal transduction (GO:1902531)	2.31	3	A2M, SORL1, PSEN1
regulation of coagulation (GO:0050818)	5.22	3	NOS3, PLAU, PSEN1
secretion (GO:0046903)	3.38	3	A2M, ACE, APP
negative regulation of signal transduction (GO:0009968)	2.75	3	SORL1, NOS3, PSEN1
regulation of response to stress (GO:0080134)	2.53	3	A2M, NOS3, PLAU
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	3	PAXIP1, APP, PSEN1
regulation of nervous system development (GO:0051960)	3.1	3	SORL1, APP, PSEN1
regulation of cell motility (GO:2000145)	3.16	3	SORL1, PLAU, ACE
regulation of immune effector process (GO:0002697)	3.71	3	A2M, PAXIP1, HFE
peptide metabolic process (GO:0006518)	3.44	3	PSEN2, ACE, PSEN1
regulation of response to external stimulus (GO:0032101)	3.06	3	A2M, NOS3, PLAU
ion homeostasis (GO:0050801)	3.42	3	PSEN1, HFE, APP
negative regulation of cellular component organization (GO:0051129)	3.35	3	SORL1, ACE, PSEN1
cellular catabolic process (GO:0044248)	2.62	3	MPO, NOS3, ACE
negative regulation of signaling (GO:0023057)	2.65	3	SORL1, NOS3, PSEN1
regulation of protein catabolic process (GO:0042176)	3.83	3	SORL1, HFE, PSEN1
regulation of cell development (GO:0060284)	3.01	3	SORL1, APP, PSEN1
cellular response to chemical stimulus (GO:0070887)	2.57	3	PLAU, HFE, APP
beta-amyloid metabolic process (GO:0050435)	7.09	3	PSEN2, ACE, PSEN1
regulation of neurogenesis (GO:0050767)	3.21	3	SORL1, APP, PSEN1
negative regulation of neurogenesis (GO:0050768)	4.22	3	SORL1, APP, PSEN1
regulation of protein modification by small protein conjugation or removal (GO:1903320)	4.14	3	PAXIP1, HFE, PSEN1
macromolecular complex subunit organization (GO:0043933)	2.14	3	MPO, PAXIP1, HFE
regulation of protein ubiquitination (GO:0031396)	4.22	3	PAXIP1, HFE, PSEN1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	PAXIP1, PSEN1, APP
cellular metal ion homeostasis (GO:0006875)	3.75	3	PSEN1, HFE, APP
cellular ion homeostasis (GO:0006873)	3.57	3	APP, HFE, PSEN1
negative regulation of cell differentiation (GO:0045596)	3.33	3	SORL1, APP, PSEN1
regulation of cell differentiation (GO:0045595)	2.42	3	SORL1, PSEN1, APP
regulation of cellular component movement (GO:0051270)	3.08	3	SORL1, PLAU, ACE
metal ion transport (GO:0030001)	3.36	3	PSEN2, HFE, PSEN1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	PAXIP1, APP, PSEN1
cellular cation homeostasis (GO:0030003)	3.6	3	APP, HFE, PSEN1
protein processing (GO:0016485)	4.62	3	PSEN2, ACE, PSEN1
response to oxidative stress (GO:0006979)	3.9	3	MPO, APP, PSEN1
negative regulation of developmental process (GO:0051093)	3.17	3	SORL1, APP, PSEN1
cellular amide metabolic process (GO:0043603)	3.23	3	PSEN2, ACE, PSEN1
positive regulation of developmental process (GO:0051094)	2.77	3	NOS3, PAXIP1, PSEN1
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	PAXIP1, PSEN1, APP
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	PAXIP1, APP, PSEN1
negative regulation of protein modification process (GO:0031400)	3.4	3	SORL1, HFE, PSEN1
regulation of cell activation (GO:0050865)	3.53	3	NOS3, PAXIP1, HFE
regulation of smooth muscle cell migration (GO:0014910)	5.84	3	SORL1, PLAU, ACE
positive regulation of cell death (GO:0010942)	3.32	3	PSEN2, APBB2, PSEN1
cell death (GO:0008219)	3.05	3	PLAU, APP, PSEN1
regulation of growth (GO:0040008)	3.26	3	MPO, APBB2, APP
negative regulation of nervous system development (GO:0051961)	4.15	3	SORL1, PSEN1, APP
positive regulation of apoptotic process (GO:0043065)	3.38	3	PSEN2, APBB2, PSEN1
negative regulation of peptidase activity (GO:0010466)	4.22	3	A2M, SORL1, APP
extracellular structure organization (GO:0043062)	4.0	3	A2M, APBB2, APP
positive regulation of programmed cell death (GO:0043068)	3.38	3	PSEN2, APBB2, PSEN1
regulation of cell migration (GO:0030334)	3.23	3	SORL1, PLAU, ACE
regulation of peptidase activity (GO:0052547)	3.75	3	A2M, SORL1, APP
regulation of endopeptidase activity (GO:0052548)	3.8	3	A2M, SORL1, APP
metal ion homeostasis (GO:0055065)	3.61	3	APP, HFE, PSEN1
negative regulation of endopeptidase activity (GO:0010951)	4.26	3	A2M, SORL1, APP
catabolic process (GO:0009056)	2.38	3	MPO, NOS3, ACE
response to oxygen-containing compound (GO:1901700)	2.57	3	MPO, PLAU, APP
regulation of locomotion (GO:0040012)	3.12	3	SORL1, PLAU, ACE
regulation of cellular component biogenesis (GO:0044087)	3.08	3	SORL1, PAXIP1, ACE
immune effector process (GO:0002252)	3.58	3	MPO, ACE, PSEN1
positive regulation of protein phosphorylation (GO:0001934)	2.95	3	ACE, HFE, PSEN1
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	2	NOS3, PSEN1
protein localization (GO:0008104)	2.36	2	SORL1, PSEN1
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	5.05	2	HFE, PSEN1
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	NOS3, PSEN1
regulation of systemic arterial blood pressure (GO:0003073)	5.99	2	NOS3, ACE
tissue remodeling (GO:0048771)	5.54	2	NOS3, ACE
behavior (GO:0007610)	3.47	2	APP, PSEN1
learning or memory (GO:0007611)	4.33	2	PSEN1, APP
regulation of lymphocyte mediated immunity (GO:0002706)	4.99	2	PAXIP1, HFE
anion transport (GO:0006820)	3.71	2	ACE, PSEN1
circulatory system process (GO:0003013)	4.38	2	NOS3, ACE
regulation of leukocyte mediated immunity (GO:0002703)	4.7	2	PAXIP1, HFE
calcium ion homeostasis (GO:0055074)	3.97	2	PSEN1, APP
cellular localization (GO:0051641)	2.32	2	SORL1, APP
regulation of production of molecular mediator of immune response (GO:0002700)	5.1	2	PAXIP1, HFE
vascular process in circulatory system (GO:0003018)	4.65	2	NOS3, ACE
regulation of anatomical structure size (GO:0090066)	3.78	2	NOS3, ACE
smooth endoplasmic reticulum calcium ion homeostasis (GO:0051563)	9.04	2	PSEN1, APP
single-organism catabolic process (GO:0044712)	3.21	2	NOS3, ACE
hormone metabolic process (GO:0042445)	4.64	2	ACE, HFE
stem cell differentiation (GO:0048863)	5.72	2	A2M, ACE
developmental growth (GO:0048589)	4.05	2	PLAU, APP
positive regulation of signal transduction (GO:0009967)	2.5	2	HFE, PSEN1
regulation of hemostasis (GO:1900046)	5.26	2	NOS3, PLAU
negative regulation of neuron differentiation (GO:0045665)	4.45	2	APP, PSEN1
regulation of neuron differentiation (GO:0045664)	3.39	2	APP, PSEN1
phosphorylation (GO:0016310)	2.63	2	PLAU, APP
macromolecule localization (GO:0033036)	2.34	2	SORL1, PSEN1
positive regulation of transport (GO:0051050)	2.9	2	SORL1, HFE
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	4.99	2	PAXIP1, HFE
organic anion transport (GO:0015711)	4.07	2	ACE, PSEN1
defense response to fungus (GO:0050832)	6.09	2	MPO, APP
secondary alcohol metabolic process (GO:1902652)	5.0	2	SORL1, APP
spermatogenesis (GO:0007283)	3.7	2	PLAU, ACE
response to metal ion (GO:0010038)	3.91	2	HFE, APP
oxoacid metabolic process (GO:0043436)	3.12	2	MPO, NOS3
divalent metal ion transport (GO:0070838)	4.15	2	PSEN2, PSEN1
response to inorganic substance (GO:0010035)	3.56	2	HFE, APP
response to other organism (GO:0051707)	3.48	2	MPO, APP
oxidation-reduction process (GO:0055114)	2.91	2	MPO, NOS3
heterocycle metabolic process (GO:0046483)	1.31	2	PAXIP1, APP
positive regulation of signaling (GO:0023056)	2.41	2	HFE, PSEN1
negative regulation of phosphorylation (GO:0042326)	3.7	2	SORL1, PSEN1
epithelial cell migration (GO:0010631)	5.42	2	NOS3, PAXIP1
transition metal ion homeostasis (GO:0055076)	5.09	2	HFE, APP
single-organism behavior (GO:0044708)	3.79	2	APP, PSEN1
response to organonitrogen compound (GO:0010243)	3.2	2	PLAU, APP
response to nutrient levels (GO:0031667)	3.77	2	MPO, HFE
removal of superoxide radicals (GO:0019430)	7.24	2	MPO, NOS3
regulation of blood coagulation (GO:0030193)	5.26	2	NOS3, PLAU
negative regulation of blood coagulation (GO:0030195)	5.88	2	NOS3, PLAU
positive regulation of catabolic process (GO:0009896)	3.94	2	SORL1, PSEN1
cellular response to growth factor stimulus (GO:0071363)	4.27	2	PLAU, APP
negative regulation of catabolic process (GO:0009895)	4.81	2	HFE, PSEN1
positive regulation of kinase activity (GO:0033674)	3.54	2	ACE, PSEN1
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	PSEN2, HFE
negative regulation of binding (GO:0051100)	4.85	2	SORL1, HFE
hematopoietic progenitor cell differentiation (GO:0002244)	5.23	2	ACE, PSEN1
negative regulation of gene expression (GO:0010629)	2.48	2	A2M, PSEN1
neuron migration (GO:0001764)	5.0	2	APBB2, PSEN1
superoxide metabolic process (GO:0006801)	6.23	2	MPO, NOS3
detoxification (GO:0098754)	5.37	2	MPO, NOS3
antigen processing and presentation of peptide antigen (GO:0048002)	4.56	2	ACE, HFE
regulation of vasodilation (GO:0042312)	5.86	2	NOS3, ACE
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	SORL1, PSEN1
ameboidal-type cell migration (GO:0001667)	4.71	2	NOS3, PAXIP1
amyloid precursor protein metabolic process (GO:0042982)	7.24	2	PSEN2, PSEN1
endothelial cell migration (GO:0043542)	5.69	2	NOS3, PAXIP1
negative regulation of protein binding (GO:0032091)	5.36	2	SORL1, HFE
organic substance catabolic process (GO:1901575)	2.45	2	NOS3, ACE
response to hypoxia (GO:0001666)	4.13	2	PSEN2, PLAU
cellular transition metal ion homeostasis (GO:0046916)	5.42	2	HFE, APP
regulation of cellular protein catabolic process (GO:1903362)	4.23	2	HFE, PSEN1
positive regulation of hydrolase activity (GO:0051345)	2.91	2	A2M, APP
exocytosis (GO:0006887)	4.11	2	A2M, APP
regulated exocytosis (GO:0045055)	4.44	2	A2M, APP
positive regulation of immune system process (GO:0002684)	2.96	2	PAXIP1, PSEN1
negative regulation of hemostasis (GO:1900047)	5.88	2	NOS3, PLAU
negative regulation of immune system process (GO:0002683)	3.85	2	A2M, HFE
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	PAXIP1, APP
regulation of MAPK cascade (GO:0043408)	3.22	2	SORL1, PSEN1
regulation of tube size (GO:0035150)	4.79	2	NOS3, ACE
negative regulation of receptor activity (GO:2000272)	6.4	2	HFE, PSEN1
antigen processing and presentation (GO:0019882)	4.36	2	ACE, HFE
lipid metabolic process (GO:0006629)	2.68	2	SORL1, APP
regulation of ERBB signaling pathway (GO:1901184)	5.3	2	PSEN1, APP
nucleobase-containing compound metabolic process (GO:0006139)	1.35	2	PAXIP1, APP
tissue development (GO:0009888)	3.27	2	PLAU, PAXIP1
calcium ion transport (GO:0006816)	4.33	2	PSEN2, PSEN1
programmed cell death (GO:0012501)	3.1	2	PSEN1, APP
regulation of multi-organism process (GO:0043900)	3.6	2	MPO, PLAU
regulation of blood vessel size (GO:0050880)	4.8	2	NOS3, ACE
regulation of blood circulation (GO:1903522)	4.05	2	NOS3, ACE
negative regulation of transferase activity (GO:0051348)	3.87	2	SORL1, PSEN1
secretion by cell (GO:0032940)	3.59	2	A2M, APP
immune response (GO:0006955)	2.86	2	HFE, APP
regulation of protein complex assembly (GO:0043254)	3.83	2	SORL1, PAXIP1
negative regulation of neuron death (GO:1901215)	4.57	2	SORL1, PSEN1
negative regulation of coagulation (GO:0050819)	5.82	2	NOS3, PLAU
endocrine process (GO:0050886)	6.43	2	NOS3, ACE
RNA metabolic process (GO:0016070)	1.59	2	PAXIP1, APP
Notch receptor processing (GO:0007220)	6.9	2	PSEN2, PSEN1
endocytosis (GO:0006897)	3.69	2	SORL1, APP
intracellular transport (GO:0046907)	2.67	2	SORL1, APP
response to decreased oxygen levels (GO:0036293)	4.09	2	PSEN2, PLAU
response to nitrogen compound (GO:1901698)	3.12	2	PLAU, APP
cellular response to nitrogen compound (GO:1901699)	3.79	2	PLAU, APP
cognition (GO:0050890)	4.2	2	PSEN1, APP
blood vessel remodeling (GO:0001974)	6.23	2	NOS3, ACE
response to yeast (GO:0001878)	7.16	2	MPO, APP
negative regulation of immune effector process (GO:0002698)	5.1	2	A2M, HFE
organonitrogen compound catabolic process (GO:1901565)	3.91	2	NOS3, ACE
negative regulation of kinase activity (GO:0033673)	4.22	2	SORL1, PSEN1
negative regulation of response to external stimulus (GO:0032102)	4.18	2	NOS3, PLAU
lipid transport (GO:0006869)	4.24	2	SORL1, ACE
regulation of synapse structure or activity (GO:0050803)	4.77	2	APP, PSEN1
response to radiation (GO:0009314)	3.69	2	PAXIP1, APP
regulation of cell adhesion (GO:0030155)	3.27	2	PLAU, HFE
membrane protein proteolysis (GO:0033619)	6.17	2	PSEN2, PSEN1
regulation of adaptive immune response (GO:0002819)	4.91	2	PAXIP1, HFE
response to growth factor (GO:0070848)	4.14	2	PLAU, APP
regulation of cellular protein localization (GO:1903827)	3.43	2	SORL1, HFE
cellular biosynthetic process (GO:0044249)	1.37	2	NOS3, PAXIP1
regulation of MAP kinase activity (GO:0043405)	3.95	2	SORL1, PSEN1
negative regulation of protein catabolic process (GO:0042177)	5.24	2	HFE, PSEN1
positive regulation of cell communication (GO:0010647)	2.41	2	HFE, PSEN1
anatomical structure morphogenesis (GO:0009653)	2.53	2	PSEN1, APP
regulation of neuron death (GO:1901214)	4.19	2	SORL1, PSEN1
response to organic cyclic compound (GO:0014070)	3.07	2	PLAU, APP
regulation of protein localization (GO:0032880)	2.88	2	SORL1, HFE
response to endogenous stimulus (GO:0009719)	2.79	2	PLAU, APP
cellular oxidant detoxification (GO:0098869)	5.45	2	MPO, NOS3
regulation of lymphocyte activation (GO:0051249)	3.73	2	PAXIP1, HFE
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	PSEN1, APP
regulation of system process (GO:0044057)	3.53	2	NOS3, ACE
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	SORL1, PSEN1
regeneration (GO:0031099)	4.7	2	PLAU, HFE
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	APP, PSEN1
negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	4.8	2	HFE, PSEN1
membrane protein ectodomain proteolysis (GO:0006509)	6.64	2	PSEN2, PSEN1
negative regulation of protein ubiquitination (GO:0031397)	4.87	2	HFE, PSEN1
biological adhesion (GO:0022610)	2.81	2	APP, PSEN1
regulation of response to wounding (GO:1903034)	4.74	2	NOS3, PLAU
negative regulation of response to wounding (GO:1903035)	5.54	2	NOS3, PLAU
cellular response to endogenous stimulus (GO:0071495)	3.33	2	PLAU, APP
sterol metabolic process (GO:0016125)	4.92	2	SORL1, APP
regulation of body fluid levels (GO:0050878)	3.76	2	NOS3, PLAU
cell proliferation (GO:0008283)	3.23	2	ACE, PSEN1
establishment of protein localization (GO:0045184)	2.53	2	SORL1, PSEN1
neurological system process (GO:0050877)	2.64	2	APP, PSEN1
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	4.32	2	HFE, PSEN1
negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051)	6.07	2	HFE, PSEN1
cellular aromatic compound metabolic process (GO:0006725)	1.3	2	PAXIP1, APP
reactive oxygen species metabolic process (GO:0072593)	5.14	2	MPO, NOS3
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	SORL1, HFE
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	PAXIP1, PSEN1
defense response to other organism (GO:0098542)	3.75	2	MPO, APP
male gamete generation (GO:0048232)	3.7	2	PLAU, ACE
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	2	NOS3, PAXIP1
steroid metabolic process (GO:0008202)	4.32	2	SORL1, APP
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	6.36	2	NOS3, ACE
negative regulation of immune response (GO:0050777)	4.94	2	A2M, HFE
divalent inorganic cation transport (GO:0072511)	4.13	2	PSEN2, PSEN1
organic acid metabolic process (GO:0006082)	3.01	2	MPO, NOS3
cellular response to organic cyclic compound (GO:0071407)	3.93	2	PLAU, APP
regulation of cell cycle (GO:0051726)	2.93	2	APBB2, APP
positive regulation of immune response (GO:0050778)	3.4	2	PAXIP1, PSEN1
response to molecule of bacterial origin (GO:0002237)	3.99	2	MPO, PLAU
regulation of cellular catabolic process (GO:0031329)	3.83	2	HFE, PSEN1
response to fluid shear stress (GO:0034405)	6.2	2	NOS3, PLAU
positive regulation of proteolysis (GO:0045862)	3.86	2	PSEN1, APP
gland development (GO:0048732)	4.15	2	HFE, PSEN1
positive regulation of protein catabolic process (GO:0045732)	4.18	2	SORL1, PSEN1
response to extracellular stimulus (GO:0009991)	3.71	2	MPO, HFE
negative regulation of growth (GO:0045926)	4.24	2	MPO, APBB2
regulation of cellular localization (GO:0060341)	3.03	2	SORL1, HFE
response to transition metal nanoparticle (GO:1990267)	4.7	2	MPO, HFE
negative regulation of cell activation (GO:0050866)	4.67	2	NOS3, HFE
regulation of epidermal growth factor receptor signaling pathway (GO:0042058)	5.33	2	APP, PSEN1
nucleic acid metabolic process (GO:0090304)	1.46	2	PAXIP1, APP
regulation of wound healing (GO:0061041)	4.88	2	NOS3, PLAU
regulation of blood pressure (GO:0008217)	4.72	2	NOS3, ACE
negative regulation of wound healing (GO:0061045)	5.65	2	NOS3, PLAU
angiogenesis (GO:0001525)	4.15	2	NOS3, PLAU
amyloid precursor protein catabolic process (GO:0042987)	7.65	2	PSEN2, PSEN1
gamete generation (GO:0007276)	3.61	2	PLAU, ACE
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	5.19	2	ACE, HFE
cholesterol metabolic process (GO:0008203)	5.03	2	SORL1, APP
growth (GO:0040007)	3.8	2	PLAU, APP
regulation of leukocyte activation (GO:0002694)	3.6	2	PAXIP1, HFE
response to lipid (GO:0033993)	3.11	2	MPO, PLAU
platelet degranulation (GO:0002576)	5.12	2	A2M, APP
positive regulation of protein kinase activity (GO:0045860)	3.61	2	ACE, PSEN1
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2000059)	7.65	2	HFE, PSEN1
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2000058)	5.12	2	HFE, PSEN1
negative regulation of cellular catabolic process (GO:0031330)	5.38	2	HFE, PSEN1
cellular response to organic substance (GO:0071310)	2.78	2	PLAU, APP
endoplasmic reticulum calcium ion homeostasis (GO:0032469)	6.73	2	APP, PSEN1
regulation of ion transport (GO:0043269)	3.4	2	NOS3, HFE
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	SORL1, PSEN1
cellular calcium ion homeostasis (GO:0006874)	4.01	2	APP, PSEN1
negative regulation of protein kinase activity (GO:0006469)	4.29	2	SORL1, PSEN1
response to oxygen levels (GO:0070482)	4.02	2	PSEN2, PLAU
negative regulation of cellular protein catabolic process (GO:1903363)	5.92	2	HFE, PSEN1
regulation of proteasomal protein catabolic process (GO:0061136)	4.78	2	HFE, PSEN1
apoptotic process (GO:0006915)	3.14	2	PSEN1, APP
regulation of hormone levels (GO:0010817)	3.56	2	ACE, HFE
regulation of metal ion transport (GO:0010959)	3.94	2	NOS3, HFE
neuron apoptotic process (GO:0051402)	6.15	2	PSEN1, APP
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	SORL1, PSEN1
establishment of localization in cell (GO:0051649)	2.47	2	SORL1, APP
cell adhesion (GO:0007155)	2.82	2	PSEN1, APP
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	SORL1, APP
carboxylic acid transport (GO:0046942)	4.28	2	ACE, PSEN1
organelle organization (GO:0006996)	2.02	2	NOS3, PSEN1
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	PLAU, APP
regulation of systemic arterial blood pressure by hormone (GO:0001990)	6.43	2	NOS3, ACE
regulation of epidermal growth factor-activated receptor activity (GO:0007176)	6.59	2	APP, PSEN1
response to fungus (GO:0009620)	5.84	2	MPO, APP
cellular detoxification (GO:1990748)	5.41	2	MPO, NOS3
alcohol metabolic process (GO:0006066)	4.2	2	SORL1, APP
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	PLAU, APP
forebrain development (GO:0030900)	5.48	2	PSEN1, APP
phosphorus metabolic process (GO:0006793)	2.15	2	PLAU, APP
protein transport (GO:0015031)	2.62	2	SORL1, PSEN1
negative regulation of protein phosphorylation (GO:0001933)	3.79	2	SORL1, PSEN1
organic hydroxy compound metabolic process (GO:1901615)	3.84	2	SORL1, APP
response to lipopolysaccharide (GO:0032496)	4.03	2	MPO, PLAU
cellular response to organonitrogen compound (GO:0071417)	3.87	2	PLAU, APP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
negative regulation of apoptotic signaling pathway (GO:2001234)	-	4.42	0.004	NOS3, PLAU, PSEN1, A2M, PSEN2, APP
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	NEW	4.69	0.002	NOS3, PLAU, PSEN1, A2M, PSEN2, APP
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	NEW	5.13	0.0	NOS3, PLAU, PSEN1, A2M, PSEN2, APP
regulation of response to stimulus (GO:0048583)	-	1.54	0.043	NOS3, SORL1, PSEN1, A2M, PAXIP1, HFE, PSEN2, PLAU, APP
hair cycle phase (GO:0044851)	NEW	9.04	0.004	PSEN2, APP, PSEN1
smooth endoplasmic reticulum calcium ion homeostasis (GO:0051563)	-	9.04	0.0	PSEN1, APP
taxis (GO:0042330)	NEW	4.03	0.021	NOS3, PLAU, PSEN1, APP, A2M, ACE
positive regulation of immune system process (GO:0002684)	-	2.96	0.0	MPO, NOS3, PLAU, PSEN1, PSEN2, APP, PAXIP1, HFE, A2M, ACE
negative regulation of molecular function (GO:0044092)	-	2.74	0.021	NOS3, SORL1, PSEN1, A2M, PSEN2, APP
chemotaxis (GO:0006935)	NEW	4.04	0.021	NOS3, PLAU, PSEN1, ACE, A2M, APP
negative regulation of cell death (GO:0060548)	-	2.95	0.001	MPO, NOS3, SORL1, PSEN1, A2M, APBB2, APP, PSEN2, PLAU, ACE
regulation of epidermal growth factor-activated receptor activity (GO:0007176)	-	6.59	0.001	PSEN2, APP, PSEN1
response to metal ion (GO:0010038)	-	3.91	0.001	NOS3, PLAU, PSEN1, A2M, ACE, PSEN2, APP
response to inorganic substance (GO:0010035)	-	3.56	0.0	MPO, NOS3, PLAU, PAXIP1, PSEN2, APP, PSEN1, A2M, ACE
vesicle-mediated transport (GO:0016192)	-	2.72	0.022	MPO, NOS3, SORL1, PSEN1, PSEN2, HFE, A2M, PLAU, APP
regulation of biological quality (GO:0065008)	-	1.68	0.01	NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
epithelial cell migration (GO:0010631)	-	5.42	0.027	NOS3, PAXIP1, ACE, APP
single-multicellular organism process (GO:0044707)	-	1.78	0.038	MPO, NOS3, PLAU, PSEN1, A2M, APP, HFE, PSEN2, ACE
cell motility (GO:0048870)	-	3.02	0.006	NOS3, SORL1, APP, PSEN1, APBB2, PAXIP1, A2M, PLAU, ACE
negative regulation of programmed cell death (GO:0043069)	-	3.02	0.007	MPO, NOS3, PLAU, PSEN1, PSEN2, APBB2, ACE, A2M, APP
positive regulation of programmed cell death (GO:0043068)	-	3.38	0.0	NOS3, PLAU, PAXIP1, A2M, APBB2, PSEN1, PSEN2, APP, ACE
extracellular matrix organization (GO:0030198)	-	4.01	0.0	NOS3, PLAU, PSEN1, A2M, APBB2, HFE, PSEN2, APP
regulation of blood coagulation (GO:0030193)	-	5.26	0.045	A2M, NOS3, PLAU, APP
regulation of beta-amyloid formation (GO:1902003)	NEW	7.53	0.001	SORL1, PSEN1, APP
negative regulation of blood coagulation (GO:0030195)	-	5.88	0.001	A2M, NOS3, PLAU, APP
response to oxygen radical (GO:0000305)	NEW	7.65	0.004	MPO, NOS3, APP
response to superoxide (GO:0000303)	NEW	7.78	0.003	MPO, NOS3, APP
cellular component movement (GO:0006928)	-	2.61	0.01	NOS3, SORL1, PAXIP1, APBB2, PSEN1, PLAU, APP
positive regulation of coagulation (GO:0050820)	NEW	6.51	0.016	PSEN2, PSEN1, APP
amyloid precursor protein catabolic process (GO:0042987)	-	7.65	0.017	PSEN2, PSEN1
amyloid precursor protein metabolic process (GO:0042982)	-	7.24	0.001	PSEN2, APP, PSEN1
regulation of systemic arterial blood pressure (GO:0003073)	-	5.99	0.05	NOS3, ACE, APP
response to hypoxia (GO:0001666)	-	4.13	0.002	NOS3, PLAU, PSEN1, A2M, ACE, PSEN2, APP
regulation of hemostasis (GO:1900046)	-	5.26	0.045	A2M, NOS3, PLAU, APP
negative regulation of hemostasis (GO:1900047)	-	5.88	0.001	A2M, NOS3, PLAU, APP
regulation of protein tyrosine kinase activity (GO:0061097)	-	5.59	0.007	PSEN2, PSEN1, APP
cell migration (GO:0016477)	-	3.12	0.003	NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, A2M, PLAU, ACE
cell activation (GO:0001775)	NEW	3.47	0.028	NOS3, PLAU, PSEN1, A2M, ACE, HFE, PSEN2, APP
regulation of protein binding (GO:0043393)	-	4.6	0.002	PSEN2, SORL1, PSEN1, NOS3, APP
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.024	NOS3, SORL1, PSEN1, PAXIP1, APP, PSEN2, PLAU, ACE
regulation of coagulation (GO:0050818)	-	5.22	0.0	NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
negative regulation of coagulation (GO:0050819)	-	5.82	0.0	A2M, NOS3, PLAU, HFE, APP
leukocyte differentiation (GO:0002521)	NEW	4.13	0.031	PLAU, PSEN1, A2M, ACE, PSEN2, APP
endocytosis (GO:0006897)	-	3.69	0.0	MPO, NOS3, SORL1, PSEN1, PSEN2, A2M, PLAU, APP
protein maturation (GO:0051604)	-	4.48	0.014	NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
response to decreased oxygen levels (GO:0036293)	-	4.09	0.002	NOS3, PLAU, PSEN1, A2M, APP, PSEN2, ACE
regulation of leukocyte activation (GO:0002694)	-	3.6	0.029	NOS3, PLAU, PSEN1, PAXIP1, ACE, A2M, APP
peptide metabolic process (GO:0006518)	-	3.44	0.04	PSEN2, ACE, NOS3, PSEN1, APP
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	NEW	6.2	0.02	PSEN2, NOS3, PLAU
lipid transport (GO:0006869)	-	4.24	0.001	NOS3, SORL1, APP, A2M, PLAU, ACE
regulation of amyloid precursor protein catabolic process (GO:1902991)	NEW	7.33	0.001	SORL1, APP, PSEN1
regulation of Rho protein signal transduction (GO:0035023)	NEW	5.02	0.048	A2M, NOS3, APP
beta-amyloid metabolic process (GO:0050435)	-	7.09	0.001	PSEN2, PSEN1, APP
anagen (GO:0042640)	NEW	9.73	0.025	PSEN2, PSEN1
regulation of cellular response to growth factor stimulus (GO:0090287)	NEW	4.29	0.002	NOS3, PLAU, PSEN1, ACE, A2M, APP
positive regulation of multicellular organismal process (GO:0051240)	-	2.49	0.04	NOS3, PLAU, PSEN1, PAXIP1, A2M, ACE, PSEN2, APP
negative regulation of multicellular organismal process (GO:0051241)	-	2.84	0.045	MPO, NOS3, PLAU, PAXIP1, HFE, A2M, APP
positive regulation of protein metabolic process (GO:0051247)	-	2.43	0.013	MPO, NOS3, HFE, SORL1, PSEN1, APP, PAXIP1, A2M, PLAU, ACE
membrane protein ectodomain proteolysis (GO:0006509)	-	6.64	0.004	PSEN2, APP, PSEN1
proteolysis (GO:0006508)	-	2.73	0.014	NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP
extracellular matrix disassembly (GO:0022617)	NEW	5.38	0.004	PSEN2, A2M, NOS3, APP, PSEN1
striated muscle cell development (GO:0055002)	NEW	5.42	0.029	BLMH, NOS3, PSEN1, APP
multicellular organismal process (GO:0032501)	-	1.45	0.045	MPO, NOS3, PLAU, PSEN1, PSEN2, APP, HFE, A2M, ACE
response to abiotic stimulus (GO:0009628)	-	2.8	0.008	MPO, NOS3, HFE, PLAU, PSEN1, A2M, ACE, PAXIP1, PSEN2, APP
regulation of cellular amide metabolic process (GO:0034248)	-	3.88	0.004	SORL1, APP, PSEN1
protein processing (GO:0016485)	-	4.62	0.004	NOS3, PSEN1, A2M, ACE, PSEN2, APP
cellular chemical homeostasis (GO:0055082)	-	3.4	0.027	NOS3, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
response to reactive oxygen species (GO:0000302)	NEW	4.5	0.022	MPO, NOS3, PAXIP1, ACE, APP
response to oxidative stress (GO:0006979)	-	3.9	0.003	MPO, NOS3, PAXIP1, APP, PSEN1, HFE, ACE
regulation of immune response (GO:0050776)	-	2.98	0.0	MPO, NOS3, HFE, PLAU, PSEN1, A2M, ACE, PAXIP1, PSEN2, APP
cellular amide metabolic process (GO:0043603)	-	3.23	0.009	PSEN2, ACE, NOS3, PSEN1, APP
leukocyte activation (GO:0045321)	NEW	3.76	0.032	NOS3, PLAU, PSEN1, A2M, APP, PSEN2, ACE
regulation of binding (GO:0051098)	-	4.08	0.015	NOS3, SORL1, PSEN1, PSEN2, PLAU, APP
negative regulation of angiogenesis (GO:0016525)	NEW	5.42	0.045	A2M, NOS3, PSEN1, APP
negative regulation of growth (GO:0045926)	-	4.24	0.029	MPO, NOS3, PSEN1, APBB2, A2M, APP
dorsal/ventral neural tube patterning (GO:0021904)	NEW	7.09	0.048	PSEN2, PSEN1
regulation of smooth muscle cell migration (GO:0014910)	-	5.84	0.001	SORL1, PLAU, ACE, APP
apoptotic signaling pathway (GO:0097190)	NEW	4.12	0.004	NOS3, PLAU, PAXIP1, A2M, PSEN1, PSEN2, APP
regulation of epidermal growth factor receptor signaling pathway (GO:0042058)	-	5.33	0.016	PSEN2, APP, PSEN1
positive regulation of cell death (GO:0010942)	-	3.32	0.0	NOS3, PLAU, PSEN1, A2M, APBB2, ACE, PAXIP1, PSEN2, APP
regulation of ERBB signaling pathway (GO:1901184)	-	5.3	0.018	PSEN2, PSEN1, APP
pattern specification process (GO:0007389)	NEW	3.79	0.033	NOS3, PLAU, PAXIP1, A2M, PSEN1, PSEN2, APP
response to lipid (GO:0033993)	-	3.11	0.007	MPO, NOS3, PLAU, PSEN1, APP, PAXIP1, HFE, A2M, ACE
angiotensin maturation (GO:0002003)	NEW	7.33	0.004	NOS3, ACE, APP
positive regulation of apoptotic process (GO:0043065)	-	3.38	0.0	NOS3, PLAU, PSEN1, PAXIP1, A2M, APBB2, ACE, PSEN2, APP
hematopoietic progenitor cell differentiation (GO:0002244)	-	5.23	0.048	PSEN2, ACE, PSEN1
negative regulation of apoptotic process (GO:0043066)	-	3.04	0.006	MPO, NOS3, PLAU, PSEN1, A2M, APBB2, APP, PSEN2, ACE
endoplasmic reticulum calcium ion homeostasis (GO:0032469)	-	6.73	0.0	PSEN2, APP, PSEN1
extracellular structure organization (GO:0043062)	-	4.0	0.0	NOS3, PLAU, PSEN1, A2M, APBB2, HFE, PSEN2, APP
regulation of receptor activity (GO:0010469)	-	4.98	0.0	PSEN2, NOS3, PLAU, APP, PSEN1
regulation of macrophage derived foam cell differentiation (GO:0010743)	NEW	6.4	0.035	A2M, NOS3, APP
biological phase (GO:0044848)	NEW	4.37	0.034	PSEN2, APP, PSEN1
response to oxygen levels (GO:0070482)	-	4.02	0.003	NOS3, PLAU, PSEN1, A2M, APP, PSEN2, ACE
locomotion (GO:0040011)	-	2.91	0.001	NOS3, SORL1, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
heart development (GO:0007507)	NEW	4.24	0.003	NOS3, PLAU, PSEN1, ACE, A2M, APP
regulation of cellular component biogenesis (GO:0044087)	-	3.08	0.01	NOS3, SORL1, PSEN1, A2M, PAXIP1, PSEN2, PLAU, APP
regulation of organ morphogenesis (GO:2000027)	NEW	4.22	0.048	A2M, NOS3, PAXIP1, ACE, APP
immune effector process (GO:0002252)	-	3.58	0.031	MPO, NOS3, PSEN1, A2M, APP, PSEN2, ACE

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
membrane-bounded organelle (GO:0043227)	0.47	13	MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
cell part (GO:0044464)	0.11	13	MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, A2M, APBB2, APP, HFE, PSEN2, PLAU, ACE
organelle (GO:0043226)	0.4	13	MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
intracellular part (GO:0044424)	0.28	12	MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, ACE
intracellular organelle (GO:0043229)	0.51	11	MPO, NOS3, SORL1, BLMH, PSEN1, APBB2, PAXIP1, HFE, PSEN2, APP, ACE
intracellular membrane-bounded organelle (GO:0043231)	0.6	11	MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, APBB2, APP, HFE, PSEN2, ACE
cytoplasmic part (GO:0044444)	0.82	10	MPO, NOS3, SORL1, BLMH, PSEN1, PSEN2, APP, HFE, A2M, ACE
membrane (GO:0016020)	0.68	9	NOS3, SORL1, PSEN1, APBB2, APP, HFE, PSEN2, PLAU, ACE
vesicle (GO:0031982)	1.64	9	MPO, BLMH, SORL1, PSEN1, APP, HFE, A2M, PLAU, ACE
intracellular organelle part (GO:0044446)	0.81	8	NOS3, SORL1, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
extracellular region part (GO:0044421)	1.57	8	MPO, BLMH, SORL1, ACE, HFE, A2M, PLAU, APP
organelle part (GO:0044422)	0.79	8	NOS3, SORL1, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
extracellular organelle (GO:0043230)	1.89	7	MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
extracellular space (GO:0005615)	2.63	7	MPO, SORL1, ACE, HFE, A2M, PLAU, APP
membrane-bounded vesicle (GO:0031988)	1.71	7	MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
plasma membrane (GO:0005886)	1.39	7	NOS3, PLAU, PSEN1, ACE, HFE, PSEN2, APP
membrane part (GO:0044425)	0.95	7	NOS3, SORL1, PSEN1, APP, HFE, PSEN2, ACE
extracellular vesicle (GO:1903561)	1.89	7	MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
plasma membrane part (GO:0044459)	1.95	7	NOS3, SORL1, PSEN1, APP, HFE, PSEN2, ACE
extracellular exosome (GO:0070062)	1.89	7	MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
cytoplasm (GO:0005737)	1.01	6	NOS3, BLMH, APBB2, ACE, PSEN2, APP
integral component of membrane (GO:0016021)	1.14	6	SORL1, PSEN1, ACE, HFE, PSEN2, APP
macromolecular complex (GO:0032991)	1.35	6	SORL1, PSEN1, PAXIP1, HFE, PSEN2, APP
nucleus (GO:0005634)	1.07	6	MPO, BLMH, NOS3, PAXIP1, APBB2, PSEN1
intrinsic component of membrane (GO:0031224)	1.13	6	SORL1, PSEN1, ACE, HFE, PSEN2, APP
protein complex (GO:0043234)	1.51	5	PSEN2, PAXIP1, PSEN1, HFE, APP
Golgi apparatus (GO:0005794)	2.7	5	PSEN2, SORL1, PSEN1, NOS3, APP
vacuole (GO:0005773)	2.92	5	MPO, ACE, SORL1, HFE, APP
Golgi apparatus part (GO:0044431)	3.0	5	PSEN2, SORL1, PSEN1, NOS3, APP
extracellular region (GO:0005576)	2.18	5	A2M, SORL1, PLAU, ACE, APP
nuclear part (GO:0044428)	1.55	5	PSEN2, SORL1, PAXIP1, PSEN1, APP
integral component of plasma membrane (GO:0005887)	2.57	5	PSEN2, SORL1, PSEN1, HFE, APP
intrinsic component of plasma membrane (GO:0031226)	2.53	5	PSEN2, SORL1, PSEN1, HFE, APP
endoplasmic reticulum (GO:0005783)	2.56	4	PSEN2, SORL1, PSEN1, APP
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	4	PSEN2, NOS3, HFE, PSEN1
cytoplasmic vesicle (GO:0031410)	2.87	4	MPO, APP, HFE, PSEN1
bounding membrane of organelle (GO:0098588)	2.39	4	PSEN2, NOS3, PSEN1, APP
Golgi membrane (GO:0000139)	3.28	4	PSEN2, NOS3, APP, PSEN1
neuron part (GO:0097458)	2.64	4	PSEN2, APBB2, PSEN1, APP
non-membrane-bounded organelle (GO:0043228)	1.76	4	PSEN2, NOS3, HFE, PSEN1
intracellular vesicle (GO:0097708)	2.86	4	MPO, PSEN1, HFE, APP
cytoskeletal part (GO:0044430)	2.49	4	PSEN2, APP, HFE, PSEN1
endosome (GO:0005768)	3.25	4	ACE, SORL1, HFE, APP
cytosol (GO:0005829)	1.68	4	A2M, NOS3, BLMH, APP
organelle membrane (GO:0031090)	1.97	4	PSEN2, NOS3, PSEN1, APP
membrane microdomain (GO:0098857)	4.17	3	NOS3, PSEN1, APP
cell projection part (GO:0044463)	2.97	3	APBB2, APP, PSEN1
organelle lumen (GO:0043233)	3.05	3	A2M, SORL1, APP
cell surface (GO:0009986)	3.44	3	PLAU, PSEN1, APP
membrane region (GO:0098589)	3.95	3	NOS3, PSEN1, APP
site of polarized growth (GO:0030427)	4.85	3	APBB2, PSEN1, APP
growth cone (GO:0030426)	4.89	3	APBB2, APP, PSEN1
membrane-enclosed lumen (GO:0031974)	3.05	3	A2M, SORL1, APP
cytoplasmic vesicle part (GO:0044433)	3.41	3	A2M, NOS3, APP
intracellular organelle lumen (GO:0070013)	3.05	3	A2M, SORL1, APP
synapse (GO:0045202)	3.58	3	APBB2, PSEN1, APP
perinuclear region of cytoplasm (GO:0048471)	3.35	3	PSEN2, HFE, APP
cell projection (GO:0042995)	2.47	3	APBB2, APP, PSEN1
cell junction (GO:0030054)	2.75	3	PLAU, APP, PSEN1
membrane raft (GO:0045121)	4.18	3	NOS3, APP, PSEN1
plasma membrane region (GO:0098590)	2.97	2	PSEN2, NOS3
lytic vacuole (GO:0000323)	3.89	2	MPO, ACE
external side of plasma membrane (GO:0009897)	4.46	2	ACE, HFE
organelle envelope lumen (GO:0031970)	5.41	2	SORL1, APP
side of membrane (GO:0098552)	4.22	2	ACE, HFE
endoplasmic reticulum membrane (GO:0005789)	2.95	2	PSEN2, PSEN1
neuromuscular junction (GO:0031594)	5.81	2	APP, PSEN1
cytoplasmic membrane-bounded vesicle lumen (GO:0060205)	5.19	2	A2M, APP
cytoskeleton (GO:0005856)	2.55	2	NOS3, HFE
lysosome (GO:0005764)	3.89	2	MPO, ACE
apical part of cell (GO:0045177)	5.34	2	HFE, APP
vesicle lumen (GO:0031983)	5.17	2	A2M, APP
platelet alpha granule lumen (GO:0031093)	5.81	2	A2M, APP
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	MPO, APP
centrosome (GO:0005813)	3.75	2	PSEN2, PSEN1
whole membrane (GO:0098805)	2.85	2	NOS3, PSEN1
mitochondrion (GO:0005739)	2.42	2	MPO, PSEN1
microtubule organizing center (GO:0005815)	3.42	2	PSEN2, PSEN1
endoplasmic reticulum part (GO:0044432)	2.73	2	PSEN2, PSEN1
synapse part (GO:0044456)	3.42	2	PSEN1, APP
vacuolar part (GO:0044437)	3.26	2	APP, PSEN1
neuron projection (GO:0043005)	3.12	2	APP, PSEN1
neuronal cell body (GO:0043025)	3.9	2	PSEN2, PSEN1
recycling endosome (GO:0055037)	5.11	2	SORL1, HFE
rough endoplasmic reticulum (GO:0005791)	5.83	2	PSEN1, APP
smooth endoplasmic reticulum (GO:0005790)	6.58	2	APP, PSEN1
ciliary rootlet (GO:0035253)	7.5	2	APP, PSEN1
cell body (GO:0044297)	3.74	2	PSEN2, PSEN1
nuclear membrane (GO:0031965)	4.2	2	PSEN2, PSEN1
lamellipodium (GO:0030027)	4.73	2	APBB2, APP
secretory granule lumen (GO:0034774)	5.38	2	A2M, APP
axon (GO:0030424)	4.15	2	APP, PSEN1
kinetochore (GO:0000776)	5.05	2	PSEN2, PSEN1
receptor complex (GO:0043235)	4.01	2	HFE, APP
dendritic shaft (GO:0043198)	6.16	2	PSEN1, APP
nuclear envelope lumen (GO:0005641)	7.72	2	SORL1, APP
organelle inner membrane (GO:0019866)	3.56	2	PSEN2, PSEN1
intracellular (GO:0005622)	2.37	2	PSEN2, PSEN1
plasma membrane protein complex (GO:0098797)	3.55	2	HFE, PSEN1
membrane protein complex (GO:0098796)	2.84	2	HFE, PSEN1
presynapse (GO:0098793)	4.97	2	APP, PSEN1
ciliary part (GO:0044441)	4.05	2	APP, PSEN1
chromosomal part (GO:0044427)	3.18	2	PSEN2, PSEN1
early endosome (GO:0005769)	4.34	2	SORL1, HFE

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
lytic vacuole (GO:0000323)	-	3.89	0.021	MPO, NOS3, PAXIP1, PLAU, APP
endoplasmic reticulum (GO:0005783)	-	2.56	0.001	MPO, NOS3, SORL1, PSEN1, A2M, HFE, PSEN2, PLAU, APP
site of polarized growth (GO:0030427)	-	4.85	0.001	PSEN2, APBB2, NOS3, PSEN1, APP
growth cone (GO:0030426)	-	4.89	0.001	PSEN2, APBB2, NOS3, APP, PSEN1
endoplasmic reticulum membrane (GO:0005789)	-	2.95	0.04	NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
neuromuscular junction (GO:0031594)	-	5.81	0.001	PSEN2, NOS3, APP, PSEN1
extracellular matrix part (GO:0044420)	NEW	4.97	0.024	A2M, NOS3, PSEN1, APP
synapse (GO:0045202)	-	3.58	0.002	PSEN2, APBB2, PLAU, PSEN1, APP
side of membrane (GO:0098552)	-	4.22	0.046	NOS3, PLAU, PSEN1, ACE, APP
membrane-bounded organelle (GO:0043227)	-	0.47	0.035	MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
extracellular space (GO:0005615)	-	2.63	0.003	MPO, NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
endoplasmic reticulum part (GO:0044432)	-	2.73	0.037	MPO, NOS3, PLAU, PSEN1, PSEN2, HFE, A2M, APP
vacuole (GO:0005773)	-	2.92	0.036	MPO, NOS3, PAXIP1, PLAU, APP
cytoplasmic vesicle (GO:0031410)	-	2.87	0.016	MPO, NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
multivesicular body (GO:0005771)	NEW	6.62	0.002	SORL1, PSEN1, APP
blood microparticle (GO:0072562)	NEW	4.88	0.043	A2M, NOS3, PLAU, APP
neuron part (GO:0097458)	-	2.64	0.036	PSEN2, APBB2, SORL1, PSEN1, APP
Golgi apparatus part (GO:0044431)	-	3.0	0.001	NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
perinuclear region of cytoplasm (GO:0048471)	-	3.35	0.038	NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
plasma membrane part (GO:0044459)	-	1.95	0.044	NOS3, SORL1, PSEN1, APP, HFE, PSEN2, ACE
apical plasma membrane (GO:0016324)	NEW	4.13	0.004	NOS3, PLAU, PSEN1, HFE, PSEN2, APP
Golgi apparatus (GO:0005794)	-	2.7	0.014	NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
ciliary rootlet (GO:0035253)	-	7.5	0.0	PSEN2, APP, PSEN1
secretory granule (GO:0030141)	NEW	4.34	0.012	MPO, A2M, NOS3, PLAU, APP
cell surface (GO:0009986)	-	3.44	0.001	NOS3, SORL1, PSEN1, A2M, HFE, PSEN2, PLAU, APP
cell cortex (GO:0005938)	NEW	4.78	0.001	PSEN2, NOS3, PLAU, APP, PSEN1
axon (GO:0030424)	-	4.15	0.033	PSEN2, APP, PSEN1
vesicle (GO:0031982)	-	1.64	0.006	MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
receptor complex (GO:0043235)	-	4.01	0.036	A2M, NOS3, PLAU, PSEN1, APP
dendritic shaft (GO:0043198)	-	6.16	0.011	PSEN2, PSEN1, APP
nuclear envelope lumen (GO:0005641)	-	7.72	0.003	SORL1, APP
membrane raft (GO:0045121)	-	4.18	0.001	PSEN2, NOS3, APP, PSEN1
lysosome (GO:0005764)	-	3.89	0.021	MPO, NOS3, PAXIP1, PLAU, APP
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.005	MPO, NOS3, PLAU, PSEN1, PSEN2, HFE, A2M, APP
extracellular region (GO:0005576)	-	2.18	0.047	MPO, NOS3, PLAU, PSEN1, PSEN2, ACE, HFE, A2M, APP
endosome (GO:0005768)	-	3.25	0.043	SORL1, PSEN1, ACE, HFE, PLAU, APP