Disease table of ALZHEIMER DISEASE OMIM ID: 104300

Gene-disease associations table

GeneAssociated with ALZHEIMER DISEASE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SORL1OMIMHGNC link11q24.11104300
NOS3OMIMHGNC link7q36.14145500, PS189800, 104300, 601367
ACEOMIMHGNC link17q23.35PS603933, 608446, 267430, 614519, 104300
PLAUOMIMHGNC link10q22.23PS231200, PS142623, 104300
MPOOMIMHGNC link17q222104300, 254600
APPClinVar, OMIM, HUMSAVARHGNC link21q21.32104300, 605714
PSEN1ClinVarHGNC link14q24.27607822, 172700, 600274, 104300, PS142690, 606889, PS115200
APBB2OMIMHGNC link4p131104300
PAXIP1OMIMHGNC link7q36.21104300
BLMHOMIMHGNC link17q11.21104300
PSEN2ClinVarHGNC link1q42.133606889, PS115200, 104300
HFEOMIMHGNC link6p22.26PS235200, PS603933, 614193, 104300, 176200, 176100
A2MOMIMHGNC link12p13.312104300, 614036

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
7q362PAXIP1, NOS3
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17q22ACE, MPO
7q32PAXIP1, NOS3
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
7q2PAXIP1, NOS3
17q3BLMH, ACE, MPO
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
173BLMH, ACE, MPO
72PAXIP1, NOS3
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
HIF1ANO80RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A2PLAU, ACE
EGR1NO90ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG3PSEN2, PLAU, ACE
JUNNO155PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC3NOS3, PLAU, APP
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC63A2M, NOS3, PLAU
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62NOS3, PLAU
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC16MPO, NOS3, PLAU, BLMH, PSEN1, APP
SP3NO109DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC62NOS3, ACE
CREB1NO90NDC80, NRF1, IFNG, NR2F1, CYP19A1, CASP8, LDHA, SMAD6, SLC19A1, GSK3A, IL10, PSEN1, PPP2R2B, JUN, HPGD, IL2, GABPA, MC2R, CRTC1, AR, FLT1, SLC39A1, BDKRB2, NPY, PTGS2, MSMB, CFTR, HMOX1, MITF, AQP3, MUC5AC, STMN1, TRH, PCSK1, MMP2, CYP17A1, NOLC1, PRL, NMNAT2, TLR9, NTS, PLAT, FOS, BCL2L11, MUC4, GSK3B, CYP11B1, PPM1D, CCK, ETV3, PTGES, UXT, HLA-DOB, CGA, XPC, ACACA, SLC22A8, TH, VIP, BDKRB1, CYP11B2, POLD2, LAPTM4B, SOX9, PLAU, SNAI1, PPP2CA, SNAI2, SPRY2, HLA-DQB1, CCL5, CXCR4, ADRA1A, NR5A2, ERBB2, GRPR, BDNF, NR4A3, IL5RA, SLC20A1, RRM2B, LYL1, BCL2, CD4, NR2F6, NF1, IL6, CYP11A1, ODC1, FOXA12PLAU, PSEN1
ATF2NO31FN1, ATF3, PLAU, IMPDH2, IFNG, PLAT, PTGS2, APOC3, NOS3, FAS, MAP3K1, RETN, TNF, PCK2, CYP11B1, CDKN1A, IFNB1, TGFB2, PCK1, JUN, RELA, DUSP10, DUSP1, ITGB8, MMP2, INS, POLB, ST3GAL5, CYP11B2, CCND1, FASLG2NOS3, PLAU
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NOS3YES11SP1, GATA4, HDAC1, DDIT3, ATF2, JUN, RELA, SP3, NFKB1, GATA2, KLF20
ACEYES4SP3, HIF1A, CREM, EGR10
PLAUYES19SP1, HIF1A, GATA6, RUNX2, EGR1, NFKB1, ATF4, HOXD3, ILF3, SRF, JUN, CREB1, ATF2, RARA, RFWD2, POU2F1, RELA, FOS, ETS10
MPOYES2SP1, RUNX10
APPYES8SP1, CTCF, TBP, NFIL3, TFAP2A, JUN, ETS2, HDAC90
PSEN1YES3SP1, CREB1, ELK10
BLMHYES2SP1, MZF10
PSEN2YES1EGR10
A2MYES3TFCP2, NFKB1, STAT30
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SORL1NOS3No1APP
SORL1APPYes5COPS5, GGA2, AURKA, APP, GGA1
SORL1PSEN1No1APP
SORL1APBB2No2WISP3, APP
SORL1PAXIP1No1APP
SORL1BLMHNo2COPS5, APP
SORL1PSEN2No1APP
SORL1A2MNo3CFTR, FBXO6, APP
NOS3ACENo1ACTB
NOS3PLAUNo1ELAVL1
NOS3APPYes16MAST1, GUCY1B3, NOS3, RNF32, EXOC6, CDC37, PI4K2A, PSEN1, HSP90AA1, A2M, CAV1, PAXIP1, AKT1, PSEN2, EXOSC1, APP
NOS3PSEN1Yes11NOS3, RNF32, APOE, CDC37, GCDH, PSEN1, APP, ST13, UMPS, PSEN2, KANK2
NOS3APBB2No1APP
NOS3PAXIP1Yes8MAST1, NOS3, UMPS, ELAVL1, TECR, RNF32, A2M, APP
NOS3BLMHNo3MAST1, RNF32, APP
NOS3PSEN2Yes10MAST1, NOS3, EXOC6, GCDH, PSEN1, ELAVL1, RNF32, PSEN2, CEP55, APP
NOS3A2MYes14MAST1, NOS3, GCDH, RNF32, APOE, CDC37, EXOSC1, ELAVL3, ACTB, PAXIP1, UMPS, A2M, FIS1, APP
ACEAPPNo1CSNK2A1
ACEPAXIP1No1CSNK2A1
ACEA2MNo1ACTB
PLAUAPPNo4BTK, MYC, SERPINB2, LRP2
PLAUPAXIP1No2SCAMP5, ELAVL1
PLAUPSEN2No1ELAVL1
APPPSEN1Yes30GSAP, KCNIP4, CTNND1, RNF32, ECSIT, CDK5, CTNNA1, NOS3, MAPT, PSMA5, UBQLN1, APP, CTNNB1, PRDX2, GAPDH, CLSTN1, NCSTN, NOTCH1, PSEN1, GFAP, TRAF6, GSK3B, CFL1, FGF13, AP1M2, CDC37, PRAM1, RAB3A, PSEN2, HERPUD1
APPAPBB2Yes7AKAP1, HSPA8, MRPL1, SYNCRIP, EGFR, APBB1, APP
APPPAXIP1Yes54TCN2, FUCA1, DDX18, TARDBP, S100A8, NOL7, PCYT1B, RNF32, A2M, ECSIT, KIF2C, LIMA1, LGALS3, APP, CLU, RPS27A, FEN1, SRRM2, SSB, GPKOW, MAPRE2, SKA3, SRSF1, RPL12, SH3GL2, PPP1CC, CDC20, ERH, MAST1, SRSF9, SNRNP70, STOML2, RNMTL1, G3BP1, NOS3, HP1BP3, ZNF622, LARP7, SRPK1, LUC7L2, C7ORF50, RPS20, CSNK2A1, PGM1, STAU1, PPIA, PLCD1, PPP2R5C, PPHLN1, PAGR1, CIRBP, PPARG, WDR5, EIF2S2
APPBLMHYes20MAST1, BLMH, ECSIT, AP1M2, MAPK8, GORASP2, MCM2, CUL4B, PES1, SYNCRIP, PDPK1, MAPRE1, LIMK1, ATL3, RNF32, RPL11, COPS5, UBE2I, G3BP1, APP
APPPSEN2Yes23PPP5C, APBA2, CHKA, RNF32, APP, NOS3, TSPAN5, UBQLN1, KCNIP4, MAST1, ECSIT, IFIT3, DNAJB1, SPC24, EXOC6, NCSTN, GFAP, PSEN1, TRAF6, FHL2, APBA3, PSEN2, APBA1
APPHFENo1SYVN1
APPA2MYes26EXOSC1, LRP1, PAXIP1, PRAM1, RNF32, A2M, ECSIT, CDK7, RAP1B, APP, NOS3, TNFRSF14, DNAJB1, IL1B, TGM2, TK1, TGIF1, MAST1, CDKN1A, PRDX2, PAEP, AP1M2, CDC37, RAB3A, IFIT3, CDK2AP2
PSEN1APBB2No1APP
PSEN1PAXIP1No7NOS3, ECSIT, RNF32, APP, UMPS, PKP4, EPB41L3
PSEN1BLMHNo5ECSIT, APP, RNF32, CYP2C8, AP1M2
PSEN1PSEN2Yes23BCL2L1, FBXL12, PDCD4, KCNIP4, RNF32, APP, GCDH, KCNIP3, UBQLN1, RHEB, FLNB, APH1B, ECSIT, APH1A, NCSTN, NOS3, TRAF6, GFAP, PSEN1, ICAM5, PSENEN, PSEN2, CIB1
PSEN1A2MNo19CYP2C18, FBXL12, NOS3, GCDH, PRDX2, RNF32, AP1M2, RAD23A, CDC37, PRAM1, STAMBPL1, RAB3A, APP, UMPS, APOE, ECSIT, TUBA1B, RHEB, CYP2C8
APBB2PAXIP1No1APP
APBB2BLMHNo3SYNCRIP, SORT1, APP
APBB2PSEN2No1APP
APBB2A2MNo1APP
PAXIP1BLMHNo5MAST1, G3BP1, ECSIT, RNF32, APP
PAXIP1PSEN2No8MAST1, NOS3, ECSIT, AAMP, ELAVL1, MGEA5, RNF32, APP
PAXIP1A2MYes9MAST1, NOS3, ECSIT, RNF32, MGEA5, UMPS, A2M, H2AFX, APP
BLMHPSEN2No4MAST1, ECSIT, RNF32, APP
BLMHA2MNo6MAST1, ECSIT, AP1M2, CYP2C8, RNF32, APP
PSEN2A2MNo13MAST1, NOS3, GCDH, ECSIT, FBXL12, IFIT5, DNAJB1, EVI5L, RNF32, MGEA5, IFIT3, RHEB, APP
HFEA2MNo1B2M

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PSEN1A2MNo1KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SORL1NOS3No-1BDNF
SORL1PLAUNo-1PLAUR
SORL1APPYesactivation, binding1BACE1
SORL1PSEN1No-3BACE1, BDNF, APP
SORL1APBB2No-1APP
SORL1BLMHNo-1APP
SORL1A2MNo-1APP
NOS3ACEYesexpression, activation, binding1BDKRB2
NOS3PLAUNo-5SRC, FOSL1, JUN, MMP9, ATF2
NOS3APPNo-26EDNRB, EDNRA, APLN, GNG2, OXT, TP53, AVP, KNG1, GNAI1, GCG, CXCL12, IL6, BDKRB2, AGTR1, TGFB1, GNB1, CNR1, HSP90AB1, VEGFA, EDN1, STAT3, GNRH1, GNAI3, CALR, IGF1, PTGER3
NOS3PSEN1No-7BDNF, DDIT3, CREB1, TP53, SRC, LEP, PRKACA
NOS3PAXIP1No-1TP53
NOS3PSEN2No-1ESR1
NOS3A2MNo-13STAT3, RHOA, PTPN11, IL10, MMP2, IGF1, TGFB1, GAB1, PDGFB, LEP, VEGFA, KNG1, RAC3
ACEAPPNo-2AGT, BDKRB2
ACEPSEN1No-1MDK
PLAUAPPNo-10FGA, LRP1, RELA, MAPK1, PLG, MAPK3, FN1, SERPINE1, NFKB1, HRG
PLAUPSEN1No-1SRC
PLAUA2MNo-6LRP1, F2, FN1, SERPINE1, PLG, HRG
APPPSEN1Yesactivation, binding10NOTCH1, APBA2, NCAM1, NCSTN, MAPK8, TP53, UBQLN1, BACE1, UBC, GSK3B
APPAPBB2Yesbinding0
APPPAXIP1No-1TP53
APPBLMHYesbinding2UBC, UBB
APPPSEN2No-6NOTCH1, NGFR, NCSTN, PSEN1, UBQLN1, UBC
APPHFENo-1B2M
APPA2MYesbinding39PF4, FN1, LEFTY2, FIGF, LRP1, ALB, SERPINE1, APOA1, KNG1, ACTN4, SRGN, ACTN1, SPARC, PROS1, CLU, ALDOA, TGFB1, F5, PPBP, MMRN1, TGFB2, PLG, VWF, F13A1, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, STAT3, TMSB4X, TGFB3, IGF2, IGF1, EGF, VEGFC, HRG, SERPINF2
PSEN1APBB2No-1APP
PSEN1PAXIP1No-1TP53
PSEN1BLMHNo-2UBC, APP
PSEN1PSEN2Yesactivation, binding24BCL2L1, EIF2AK3, KCNIP4, FLNC, DLL1, SRI, NOTCH3, NOTCH4, UBQLN1, KCNIP3, METTL2B, DNER, ATF6, APH1B, RYR2, NCSTN, ICAM5, TRAF6, MTCH1, NOTCH1, FLNB, PSENEN, UBC, ERN1
PSEN1A2MNo-3LEP, GRB2, APP
APBB2BLMHNo-1APP
APBB2A2MNo-1APP
BLMHPSEN2No-1UBC
BLMHA2MNo-1APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
APPA2MNo-1LRP1
PSEN1PSEN2No-4APH1B, NCSTN, APH1A, PSENEN

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
ACEAPPYes2ACE, APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Alzheimer's diseasehsa050105.343PSEN2, APP, PSEN1
Notch signaling pathwayhsa043307.122PSEN2, PSEN1
Neurotrophin signaling pathwayhsa047225.782PSEN2, PSEN1
Complement and coagulation cascadeshsa046106.582A2M, PLAU
Transcriptional misregulation in cancerhsa052025.212MPO, PLAU

NET-GE enrichment

Term New enriched termICP valueGenes
Immune diseasesNEW4.470.007MPO, NOS3, PSEN1, ACE, A2M, APP
Renin-angiotensin system (hsa04614) NEW8.680.002NOS3, ACE, APP
Cancers: OverviewNEW2.720.013MPO, NOS3, HFE, PLAU, PSEN1, APP, PAXIP1, A2M, ACE
Infectious diseases: ParasiticNEW4.460.009NOS3, PLAU, PSEN1, ACE, A2M, APP
Complement and coagulation cascades (hsa04610) -6.580.047A2M, PLAU, APP
Salmonella infection (hsa05132) NEW6.290.007NOS3, PLAU, PSEN1, APP
Inflammatory bowel disease (IBD) (hsa05321) NEW6.430.002A2M, NOS3, PSEN1, APP
Transcriptional misregulation in cancer (hsa05202) -5.210.02MPO, NOS3, PLAU, PSEN1, APP
Digestive systemNEW4.120.043NOS3, PLAU, PSEN1, A2M, PSEN2, APP
Immune systemNEW2.920.034MPO, NOS3, PLAU, PSEN1, ACE, HFE, A2M, APP
MAPK signaling pathway (hsa04010) NEW4.630.002NOS3, PLAU, PSEN1, ACE, A2M, APP
Neurotrophin signaling pathway (hsa04722) -5.780.017PSEN2, NOS3, APP, PSEN1
Alzheimer's disease (hsa05010) -5.340.031PSEN2, NOS3, APP, PSEN1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
HemostasisR-HSA-1095823.984A2M, NOS3, PLAU, APP
Signal TransductionR-HSA-1625821.784PSEN2, A2M, NOS3, APP
Extracellular matrix organizationR-HSA-14742444.913A2M, PSEN1, APP
DiseaseR-HSA-16436853.333PSEN2, NOS3, APP
Platelet degranulation R-HSA-1146086.682A2M, APP
Platelet activation, signaling and aggregationR-HSA-760025.152A2M, APP
Immune SystemR-HSA-1682562.372BLMH, APP
Degradation of the extracellular matrixR-HSA-14742286.112A2M, PSEN1
Response to elevated platelet cytosolic Ca2+R-HSA-760056.592A2M, APP
MetabolismR-HSA-14307282.342A2M, NOS3

NET-GE enrichment

Term New enriched termICP valueGenes
PPARA activates gene expression (R-HSA-1989781) NEW6.180.033NOS3, PAXIP1, ACE, APP
Signalling by NGF (R-HSA-166520) NEW4.230.009NOS3, PLAU, BLMH, PSEN1, APP, PSEN2, ACE
Platelet activation, signaling and aggregation (R-HSA-76002) -5.150.047MPO, A2M, NOS3, PLAU, APP
Degradation of the extracellular matrix (R-HSA-1474228) -6.110.039PSEN2, A2M, PSEN1, APP
Extracellular matrix organization (R-HSA-1474244) -4.910.0NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
Signaling by ERBB4 (R-HSA-1236394) NEW4.70.011NOS3, PLAU, PSEN1, ACE, PSEN2, APP
Axon guidance (R-HSA-422475) NEW3.930.029NOS3, PLAU, BLMH, PSEN1, ACE, PSEN2, APP
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (R-HSA-400206) NEW6.140.037NOS3, PAXIP1, ACE, APP
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1813MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
protein binding (GO:0005515) 0.4612NOS3, APP, SORL1, BLMH, PSEN1, A2M, APBB2, PAXIP1, HFE, PSEN2, PLAU, ACE
catalytic activity (GO:0003824) 1.057MPO, NOS3, PLAU, BLMH, PSEN1, PSEN2, ACE
hydrolase activity (GO:0016787) 1.95PSEN2, PLAU, BLMH, ACE, PSEN1
peptidase activity (GO:0008233) 3.235PSEN2, BLMH, PLAU, PSEN1, ACE
endopeptidase activity (GO:0004175) 3.635PSEN2, ACE, PLAU, BLMH, PSEN1
peptidase activity, acting on L-amino acid peptides (GO:0070011) 3.265PSEN2, PLAU, BLMH, ACE, PSEN1
cation binding (GO:0043169) 1.44MPO, NOS3, ACE, APP
receptor binding (GO:0005102) 2.434A2M, ACE, HFE, APP
metal ion binding (GO:0046872) 1.414MPO, NOS3, ACE, APP
enzyme binding (GO:0019899) 2.274A2M, SORL1, ACE, APP
ion binding (GO:0043167) 1.364MPO, NOS3, ACE, APP
peptide binding (GO:0042277) 4.223SORL1, APBB2, HFE
transition metal ion binding (GO:0046914) 2.483NOS3, ACE, APP
carbohydrate derivative binding (GO:0097367) 2.033MPO, NOS3, APP
organic cyclic compound binding (GO:0097159) 1.053MPO, NOS3, APP
amide binding (GO:0033218) 4.143SORL1, APBB2, HFE
heterocyclic compound binding (GO:1901363) 1.063MPO, NOS3, APP
peptidase inhibitor activity (GO:0030414) 4.552A2M, APP
exopeptidase activity (GO:0008238) 5.072BLMH, ACE
macromolecular complex binding (GO:0044877) 2.612MPO, SORL1
enzyme activator activity (GO:0008047) 3.562A2M, APP
enzyme inhibitor activity (GO:0004857) 3.782A2M, APP
molecular function regulator (GO:0098772) 2.512A2M, APP
serine-type peptidase activity (GO:0008236) 4.272PLAU, ACE
sulfur compound binding (GO:1901681) 4.322MPO, APP
aspartic-type peptidase activity (GO:0070001) 6.12PSEN2, PSEN1
beta-amyloid binding (GO:0001540) 6.212SORL1, APBB2
carboxypeptidase activity (GO:0004180) 6.02BLMH, ACE
actin binding (GO:0003779) 3.742NOS3, ACE
oxidoreductase activity (GO:0016491) 3.122MPO, NOS3
endopeptidase regulator activity (GO:0061135) 4.572A2M, APP
anion binding (GO:0043168) 4.172NOS3, ACE
heme binding (GO:0020037) 4.862MPO, NOS3
serine hydrolase activity (GO:0017171) 4.262PLAU, ACE
enzyme regulator activity (GO:0030234) 2.852A2M, APP
peptidase regulator activity (GO:0061134) 4.372A2M, APP
protein domain specific binding (GO:0019904) 3.322PSEN1, APP
endopeptidase inhibitor activity (GO:0004866) 4.62A2M, APP
serine-type endopeptidase inhibitor activity (GO:0004867) 5.162A2M, APP
heparin binding (GO:0008201) 4.682MPO, APP
cytoskeletal protein binding (GO:0008092) 3.022NOS3, ACE
tetrapyrrole binding (GO:0046906) 4.82MPO, NOS3
glycosaminoglycan binding (GO:0005539) 4.422MPO, APP
aspartic-type endopeptidase activity (GO:0004190) 6.132PSEN2, PSEN1

NET-GE enrichment

Term New enriched termICP valueGenes
serine-type endopeptidase activity (GO:0004252) NEW4.40.003A2M, NOS3, PLAU, HFE, APP
endopeptidase activity (GO:0004175) -3.630.0NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP
C-X-C chemokine binding (GO:0019958) NEW7.790.005A2M, APP
interleukin-8 binding (GO:0019959) NEW8.640.001A2M, APP
chemokine binding (GO:0019956) NEW6.690.038A2M, APP
cytokine binding (GO:0019955) NEW5.210.005MPO, A2M, NOS3, APP
enzyme binding (GO:0019899) -2.270.012NOS3, SORL1, BLMH, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
drug binding (GO:0008144) NEW5.030.016NOS3, PLAU, ACE, APP
exopeptidase activity (GO:0008238) -5.070.009A2M, BLMH, ACE, APP
peptidase activity (GO:0008233) -3.230.0NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP
serine-type peptidase activity (GO:0008236) -4.270.006A2M, NOS3, PLAU, HFE, APP
sulfur compound binding (GO:1901681) -4.320.001MPO, NOS3, PLAU, ACE, A2M, APP
beta-amyloid binding (GO:0001540) -6.210.027APBB2, SORL1, APP, PSEN1
carboxypeptidase activity (GO:0004180) -6.00.009BLMH, ACE, APP
growth factor binding (GO:0019838) NEW4.890.022A2M, NOS3, PLAU, APP
protease binding (GO:0002020) NEW5.080.004A2M, PLAU, PSEN1, APP
peptidyl-dipeptidase activity (GO:0008241) NEW8.350.003NOS3, ACE
serine hydrolase activity (GO:0017171) -4.260.007A2M, NOS3, PLAU, HFE, APP
amide binding (GO:0033218) -4.140.022APBB2, SORL1, PSEN1, HFE, APP
peptide binding (GO:0042277) -4.220.021APBB2, SORL1, PSEN1, HFE, APP
heparin binding (GO:0008201) -4.680.0MPO, NOS3, PLAU, ACE, A2M, APP
glycosaminoglycan binding (GO:0005539) -4.420.001MPO, NOS3, PLAU, ACE, A2M, APP
peptidase activity, acting on L-amino acid peptides (GO:0070011) -3.260.011NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2613MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
biological regulation (GO:0065007) 0.3912MPO, NOS3, SORL1, PSEN1, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
regulation of biological process (GO:0050789) 0.4512MPO, NOS3, HFE, SORL1, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
metabolic process (GO:0008152) 0.5812MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
regulation of cellular process (GO:0050794) 0.512MPO, NOS3, HFE, SORL1, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
negative regulation of biological process (GO:0048519) 1.3311MPO, NOS3, SORL1, PSEN1, A2M, APBB2, APP, HFE, PSEN2, PLAU, ACE
single-organism cellular process (GO:0044763) 0.6511MPO, NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
single-organism process (GO:0044699) 0.4811MPO, NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
organic substance metabolic process (GO:0071704) 0.6311MPO, NOS3, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
primary metabolic process (GO:0044238) 0.6910NOS3, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
regulation of metabolic process (GO:0019222) 1.0210NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
response to stimulus (GO:0050896) 1.2210MPO, NOS3, PLAU, BLMH, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
regulation of cellular metabolic process (GO:0031323) 1.0710NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, HFE, A2M, PLAU, ACE
positive regulation of biological process (GO:0048518) 1.210NOS3, SORL1, APP, PSEN1, APBB2, PAXIP1, HFE, PSEN2, PLAU, ACE
negative regulation of cellular process (GO:0048523) 1.4110MPO, NOS3, SORL1, PSEN1, A2M, APBB2, APP, HFE, PSEN2, ACE
positive regulation of cellular process (GO:0048522) 1.310NOS3, SORL1, APP, PSEN1, APBB2, PAXIP1, HFE, PSEN2, PLAU, ACE
regulation of primary metabolic process (GO:0080090) 1.089NOS3, HFE, SORL1, PSEN1, APBB2, APP, PAXIP1, A2M, ACE
protein metabolic process (GO:0019538) 1.459BLMH, SORL1, PSEN1, PAXIP1, A2M, ACE, PSEN2, PLAU, APP
cellular metabolic process (GO:0044237) 0.699MPO, NOS3, PLAU, BLMH, PAXIP1, APP, PSEN1, PSEN2, ACE
macromolecule metabolic process (GO:0043170) 0.839BLMH, SORL1, PSEN1, A2M, ACE, PAXIP1, PSEN2, PLAU, APP
signal transduction (GO:0007165) 1.289NOS3, SORL1, PAXIP1, APBB2, PSEN1, HFE, PSEN2, PLAU, APP
regulation of molecular function (GO:0065009) 1.789NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
developmental process (GO:0032502) 1.368MPO, NOS3, PLAU, PAXIP1, APP, PSEN1, HFE, ACE
positive regulation of metabolic process (GO:0009893) 1.748NOS3, SORL1, PAXIP1, APP, PSEN1, HFE, PLAU, ACE
regulation of macromolecule metabolic process (GO:0060255) 1.088HFE, SORL1, PAXIP1, APBB2, PSEN1, ACE, A2M, APP
positive regulation of molecular function (GO:0044093) 2.238NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
regulation of response to stimulus (GO:0048583) 1.548NOS3, SORL1, PAXIP1, PSEN1, HFE, A2M, PLAU, APP
cellular component organization (GO:0016043) 1.248MPO, NOS3, PAXIP1, APBB2, PSEN1, HFE, A2M, APP
single-organism developmental process (GO:0044767) 1.498MPO, NOS3, PLAU, PAXIP1, APP, PSEN1, HFE, ACE
response to stress (GO:0006950) 1.88MPO, NOS3, PLAU, PAXIP1, PSEN1, HFE, PSEN2, APP
regulation of multicellular organismal process (GO:0051239) 1.878NOS3, SORL1, PSEN1, PAXIP1, APP, HFE, PLAU, ACE
cellular component organization or biogenesis (GO:0071840) 1.228MPO, NOS3, PAXIP1, APBB2, PSEN1, HFE, A2M, APP
establishment of localization (GO:0051234) 1.487SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
single-multicellular organism process (GO:0044707) 1.787MPO, NOS3, PLAU, PSEN1, ACE, HFE, APP
regulation of catalytic activity (GO:0050790) 1.977NOS3, SORL1, PSEN1, A2M, APP, PSEN2, ACE
regulation of developmental process (GO:0050793) 2.17NOS3, SORL1, PAXIP1, APP, PSEN1, PLAU, ACE
positive regulation of cellular metabolic process (GO:0031325) 1.817NOS3, PLAU, PSEN1, PAXIP1, ACE, HFE, APP
anatomical structure development (GO:0048856) 1.587NOS3, PLAU, PSEN1, PAXIP1, ACE, HFE, APP
regulation of protein metabolic process (GO:0051246) 1.937SORL1, PAXIP1, APP, PSEN1, HFE, A2M, ACE
regulation of cellular protein metabolic process (GO:0032268) 1.997SORL1, PSEN1, PAXIP1, ACE, HFE, A2M, APP
regulation of signal transduction (GO:0009966) 1.847NOS3, SORL1, PSEN1, HFE, A2M, PLAU, APP
regulation of biological quality (GO:0065008) 1.687NOS3, SORL1, PSEN1, APP, HFE, PLAU, ACE
multicellular organismal process (GO:0032501) 1.457MPO, NOS3, PLAU, PSEN1, APP, HFE, ACE
regulation of multicellular organismal development (GO:2000026) 2.317NOS3, SORL1, PAXIP1, APP, PSEN1, PLAU, ACE
regulation of nitrogen compound metabolic process (GO:0051171) 1.367NOS3, SORL1, PAXIP1, APBB2, PSEN1, HFE, APP
transport (GO:0006810) 1.517SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
regulation of signaling (GO:0023051) 1.727NOS3, SORL1, PSEN1, HFE, A2M, PLAU, APP
regulation of cell communication (GO:0010646) 1.737NOS3, SORL1, PSEN1, HFE, A2M, PLAU, APP
localization (GO:0051179) 1.47SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
positive regulation of catalytic activity (GO:0043085) 2.47NOS3, SORL1, PSEN1, A2M, APP, PSEN2, ACE
response to abiotic stimulus (GO:0009628) 2.86MPO, NOS3, PLAU, PAXIP1, PSEN2, APP
single-organism metabolic process (GO:0044710) 1.636MPO, NOS3, SORL1, PSEN1, APP, ACE
regulation of cell death (GO:0010941) 2.436MPO, NOS3, SORL1, PSEN1, APBB2, PSEN2
regulation of phosphate metabolic process (GO:0019220) 2.356NOS3, SORL1, PSEN1, APP, HFE, ACE
positive regulation of macromolecule metabolic process (GO:0010604) 1.816HFE, SORL1, PAXIP1, PSEN1, ACE, APP
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436NOS3, PAXIP1, APBB2, PSEN1, HFE, APP
negative regulation of cell death (GO:0060548) 2.956MPO, NOS3, SORL1, PSEN1, APBB2, PSEN2
negative regulation of response to stimulus (GO:0048585) 2.526NOS3, SORL1, PSEN1, HFE, A2M, PLAU
negative regulation of multicellular organismal process (GO:0051241) 2.846NOS3, SORL1, PSEN1, HFE, PLAU, APP
regulation of biosynthetic process (GO:0009889) 1.376NOS3, PSEN1, APBB2, PAXIP1, HFE, APP
positive regulation of protein metabolic process (GO:0051247) 2.436HFE, SORL1, PAXIP1, PSEN1, ACE, APP
regulation of cellular biosynthetic process (GO:0031326) 1.386NOS3, PAXIP1, APBB2, PSEN1, HFE, APP
regulation of cellular component organization (GO:0051128) 2.016SORL1, PAXIP1, APBB2, PSEN1, HFE, ACE
regulation of phosphorus metabolic process (GO:0051174) 2.356NOS3, SORL1, PSEN1, ACE, HFE, APP
regulation of protein modification process (GO:0031399) 2.326HFE, SORL1, PSEN1, PAXIP1, ACE, APP
cellular nitrogen compound metabolic process (GO:0034641) 1.226NOS3, PAXIP1, APP, PSEN1, PSEN2, ACE
nitrogen compound metabolic process (GO:0006807) 1.136NOS3, PAXIP1, APP, PSEN1, PSEN2, ACE
negative regulation of molecular function (GO:0044092) 2.746NOS3, SORL1, PSEN1, HFE, A2M, APP
movement of cell or subcellular component (GO:0006928) 2.616NOS3, PLAU, PAXIP1, APBB2, PSEN1, APP
regulation of gene expression (GO:0010468) 1.376PAXIP1, APBB2, PSEN1, HFE, A2M, APP
negative regulation of metabolic process (GO:0009892) 1.935A2M, SORL1, HFE, PSEN1, APP
negative regulation of cellular metabolic process (GO:0031324) 2.015A2M, SORL1, PSEN1, APP, HFE
homeostatic process (GO:0042592) 2.615NOS3, PLAU, HFE, PSEN1, APP
cell surface receptor signaling pathway (GO:0007166) 2.095PSEN2, NOS3, HFE, PSEN1, APP
intracellular signal transduction (GO:0035556) 2.395PSEN2, NOS3, PAXIP1, APBB2, PSEN1
regulation of apoptotic process (GO:0042981) 2.55PSEN2, MPO, NOS3, APBB2, PSEN1
negative regulation of catalytic activity (GO:0043086) 3.05A2M, SORL1, NOS3, PSEN1, APP
cellular protein metabolic process (GO:0044267) 1.635PSEN2, BLMH, PAXIP1, PSEN1, APP
cellular response to stimulus (GO:0051716) 1.975APP, PLAU, PAXIP1, HFE, PSEN1
negative regulation of macromolecule metabolic process (GO:0010605) 2.015A2M, SORL1, PSEN1, APP, HFE
cellular macromolecule metabolic process (GO:0044260) 0.935PSEN2, BLMH, PAXIP1, PSEN1, APP
cellular developmental process (GO:0048869) 1.825A2M, ACE, PAXIP1, PSEN1, APP
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465APBB2, APP, PAXIP1, HFE, PSEN1
regulation of programmed cell death (GO:0043067) 2.495PSEN2, MPO, NOS3, APBB2, PSEN1
negative regulation of apoptotic process (GO:0043066) 3.045PSEN2, MPO, NOS3, APBB2, PSEN1
regulation of immune system process (GO:0002682) 2.55A2M, ACE, PAXIP1, HFE, PSEN1
positive regulation of cellular protein metabolic process (GO:0032270) 2.495ACE, APP, PAXIP1, HFE, PSEN1
cell migration (GO:0016477) 3.125APBB2, NOS3, PAXIP1, PLAU, PSEN1
negative regulation of programmed cell death (GO:0043069) 3.025PSEN2, MPO, NOS3, APBB2, PSEN1
cellular homeostasis (GO:0019725) 3.235NOS3, PLAU, HFE, PSEN1, APP
locomotion (GO:0040011) 2.915NOS3, PLAU, PAXIP1, APBB2, PSEN1
negative regulation of protein metabolic process (GO:0051248) 2.825A2M, SORL1, PSEN1, HFE, APP
regulation of nucleic acid-templated transcription (GO:1903506) 1.555PAXIP1, APBB2, PSEN1, HFE, APP
reproductive process (GO:0022414) 2.555ACE, NOS3, PLAU, HFE, APP
regulation of proteolysis (GO:0030162) 3.25A2M, SORL1, PSEN1, APP, HFE
regulation of RNA biosynthetic process (GO:2001141) 1.555PAXIP1, APBB2, PSEN1, HFE, APP
response to chemical (GO:0042221) 1.985MPO, BLMH, PLAU, HFE, APP
regulation of localization (GO:0032879) 1.945ACE, SORL1, PLAU, NOS3, HFE
proteolysis (GO:0006508) 2.735PSEN2, ACE, PLAU, BLMH, PSEN1
regulation of phosphorylation (GO:0042325) 2.55ACE, SORL1, HFE, PSEN1, APP
negative regulation of cellular protein metabolic process (GO:0032269) 2.885A2M, SORL1, PSEN1, APP, HFE
cell motility (GO:0048870) 3.025APBB2, NOS3, PAXIP1, PLAU, PSEN1
regulation of RNA metabolic process (GO:0051252) 1.525APBB2, APP, PAXIP1, HFE, PSEN1
immune system process (GO:0002376) 2.295MPO, ACE, APP, HFE, PSEN1
regulation of transcription, DNA-templated (GO:0006355) 1.565PAXIP1, APBB2, PSEN1, HFE, APP
regulation of macromolecule biosynthetic process (GO:0010556) 1.435PAXIP1, APBB2, PSEN1, HFE, APP
negative regulation of proteolysis (GO:0045861) 3.985A2M, SORL1, PSEN1, APP, HFE
regulation of protein phosphorylation (GO:0001932) 2.575ACE, SORL1, HFE, PSEN1, APP
regulation of binding (GO:0051098) 4.084SORL1, PSEN1, HFE, APP
positive regulation of biosynthetic process (GO:0009891) 2.294NOS3, PAXIP1, APP, PSEN1
cell differentiation (GO:0030154) 2.144A2M, PAXIP1, ACE, PSEN1
positive regulation of gene expression (GO:0010628) 2.354PAXIP1, PSEN1, HFE, APP
positive regulation of cellular biosynthetic process (GO:0031328) 2.34NOS3, PAXIP1, PSEN1, APP
small molecule metabolic process (GO:0044281) 2.384MPO, SORL1, NOS3, APP
negative regulation of hydrolase activity (GO:0051346) 3.744A2M, SORL1, NOS3, APP
positive regulation of phosphorus metabolic process (GO:0010562) 2.784ACE, NOS3, HFE, PSEN1
regulation of kinase activity (GO:0043549) 3.074ACE, SORL1, APP, PSEN1
animal organ development (GO:0048513) 2.534ACE, NOS3, HFE, PSEN1
regulation of receptor activity (GO:0010469) 4.984APP, PLAU, HFE, PSEN1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354NOS3, PAXIP1, APP, PSEN1
multicellular organismal reproductive process (GO:0048609) 3.354NOS3, PLAU, ACE, APP
positive regulation of phosphate metabolic process (GO:0045937) 2.784ACE, NOS3, HFE, PSEN1
ion transport (GO:0006811) 2.664PSEN2, ACE, HFE, PSEN1
regulation of protein kinase activity (GO:0045859) 3.154ACE, SORL1, APP, PSEN1
cellular protein modification process (GO:0006464) 1.794BLMH, PAXIP1, PSEN1, APP
biosynthetic process (GO:0009058) 1.324MPO, NOS3, PAXIP1, HFE
single-organism transport (GO:0044765) 2.184A2M, SORL1, ACE, APP
protein modification process (GO:0036211) 1.794BLMH, PAXIP1, PSEN1, APP
regulation of protein binding (GO:0043393) 4.64SORL1, PSEN1, HFE, APP
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294NOS3, PAXIP1, PSEN1, APP
cellular chemical homeostasis (GO:0055082) 3.44APP, PLAU, HFE, PSEN1
single-organism localization (GO:1902578) 2.094A2M, SORL1, ACE, APP
system process (GO:0003008) 2.34ACE, NOS3, PSEN1, APP
regulation of hydrolase activity (GO:0051336) 2.534A2M, SORL1, NOS3, APP
regulation of immune response (GO:0050776) 2.984A2M, PAXIP1, HFE, PSEN1
organonitrogen compound metabolic process (GO:1901564) 2.324PSEN2, NOS3, ACE, PSEN1
protein maturation (GO:0051604) 4.484PSEN2, SORL1, ACE, PSEN1
response to external stimulus (GO:0009605) 2.554MPO, PLAU, HFE, APP
positive regulation of protein modification process (GO:0031401) 2.74ACE, PAXIP1, HFE, PSEN1
macromolecule modification (GO:0043412) 1.734BLMH, PAXIP1, PSEN1, APP
regulation of transferase activity (GO:0051338) 2.884ACE, SORL1, APP, PSEN1
chemical homeostasis (GO:0048878) 2.974APP, PLAU, HFE, PSEN1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244PAXIP1, PSEN1, HFE, APP
cellular response to stress (GO:0033554) 2.514PLAU, PAXIP1, HFE, PSEN1
positive regulation of multicellular organismal process (GO:0051240) 2.494NOS3, PAXIP1, PLAU, PSEN1
regulation of transport (GO:0051049) 2.243SORL1, NOS3, HFE
positive regulation of response to stimulus (GO:0048584) 2.183PAXIP1, HFE, PSEN1
cation homeostasis (GO:0055080) 3.463APP, HFE, PSEN1
inorganic ion homeostasis (GO:0098771) 3.433PSEN1, HFE, APP
organic cyclic compound metabolic process (GO:1901360) 1.263SORL1, PAXIP1, APP
Notch signaling pathway (GO:0007219) 4.993PSEN2, APP, PSEN1
response to external biotic stimulus (GO:0043207) 3.133MPO, PLAU, APP
negative regulation of cell development (GO:0010721) 4.023SORL1, APP, PSEN1
regulation of cell proliferation (GO:0042127) 2.413NOS3, PLAU, ACE
organic substance transport (GO:0071702) 2.153SORL1, ACE, PSEN1
response to organic substance (GO:0010033) 2.23MPO, PLAU, APP
multi-organism process (GO:0051704) 2.653MPO, HFE, APP
positive regulation of phosphorylation (GO:0042327) 2.93ACE, HFE, PSEN1
single organism reproductive process (GO:0044702) 2.733NOS3, PLAU, ACE
response to biotic stimulus (GO:0009607) 3.093MPO, PLAU, APP
vesicle-mediated transport (GO:0016192) 2.723A2M, SORL1, APP
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.353ACE, APP, PSEN1
extracellular matrix organization (GO:0030198) 4.013A2M, APBB2, APP
negative regulation of cell communication (GO:0010648) 2.663SORL1, NOS3, PSEN1
regulation of catabolic process (GO:0009894) 3.523SORL1, HFE, PSEN1
cellular component assembly (GO:0022607) 2.143PSEN1, HFE, APP
regulation of anatomical structure morphogenesis (GO:0022603) 2.793NOS3, PLAU, PSEN1
positive regulation of transferase activity (GO:0051347) 3.313SORL1, ACE, PSEN1
neuron death (GO:0070997) 5.863PLAU, APP, PSEN1
regulation of protein tyrosine kinase activity (GO:0061097) 5.593ACE, PSEN1, APP
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013NOS3, PLAU, PSEN1
positive regulation of cellular component organization (GO:0051130) 2.683PAXIP1, HFE, PSEN1
cation transport (GO:0006812) 3.113PSEN2, HFE, PSEN1
defense response (GO:0006952) 2.783MPO, HFE, APP
regulation of intracellular signal transduction (GO:1902531) 2.313A2M, SORL1, PSEN1
regulation of coagulation (GO:0050818) 5.223NOS3, PLAU, PSEN1
secretion (GO:0046903) 3.383A2M, ACE, APP
negative regulation of signal transduction (GO:0009968) 2.753SORL1, NOS3, PSEN1
regulation of response to stress (GO:0080134) 2.533A2M, NOS3, PLAU
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393PAXIP1, APP, PSEN1
regulation of nervous system development (GO:0051960) 3.13SORL1, APP, PSEN1
regulation of cell motility (GO:2000145) 3.163SORL1, PLAU, ACE
regulation of immune effector process (GO:0002697) 3.713A2M, PAXIP1, HFE
peptide metabolic process (GO:0006518) 3.443PSEN2, ACE, PSEN1
regulation of response to external stimulus (GO:0032101) 3.063A2M, NOS3, PLAU
ion homeostasis (GO:0050801) 3.423PSEN1, HFE, APP
negative regulation of cellular component organization (GO:0051129) 3.353SORL1, ACE, PSEN1
cellular catabolic process (GO:0044248) 2.623MPO, NOS3, ACE
negative regulation of signaling (GO:0023057) 2.653SORL1, NOS3, PSEN1
regulation of protein catabolic process (GO:0042176) 3.833SORL1, HFE, PSEN1
regulation of cell development (GO:0060284) 3.013SORL1, APP, PSEN1
cellular response to chemical stimulus (GO:0070887) 2.573PLAU, HFE, APP
beta-amyloid metabolic process (GO:0050435) 7.093PSEN2, ACE, PSEN1
regulation of neurogenesis (GO:0050767) 3.213SORL1, APP, PSEN1
negative regulation of neurogenesis (GO:0050768) 4.223SORL1, APP, PSEN1
regulation of protein modification by small protein conjugation or removal (GO:1903320) 4.143PAXIP1, HFE, PSEN1
macromolecular complex subunit organization (GO:0043933) 2.143MPO, PAXIP1, HFE
regulation of protein ubiquitination (GO:0031396) 4.223PAXIP1, HFE, PSEN1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563PAXIP1, PSEN1, APP
cellular metal ion homeostasis (GO:0006875) 3.753PSEN1, HFE, APP
cellular ion homeostasis (GO:0006873) 3.573APP, HFE, PSEN1
negative regulation of cell differentiation (GO:0045596) 3.333SORL1, APP, PSEN1
regulation of cell differentiation (GO:0045595) 2.423SORL1, PSEN1, APP
regulation of cellular component movement (GO:0051270) 3.083SORL1, PLAU, ACE
metal ion transport (GO:0030001) 3.363PSEN2, HFE, PSEN1
positive regulation of transcription, DNA-templated (GO:0045893) 2.563PAXIP1, APP, PSEN1
cellular cation homeostasis (GO:0030003) 3.63APP, HFE, PSEN1
protein processing (GO:0016485) 4.623PSEN2, ACE, PSEN1
response to oxidative stress (GO:0006979) 3.93MPO, APP, PSEN1
negative regulation of developmental process (GO:0051093) 3.173SORL1, APP, PSEN1
cellular amide metabolic process (GO:0043603) 3.233PSEN2, ACE, PSEN1
positive regulation of developmental process (GO:0051094) 2.773NOS3, PAXIP1, PSEN1
positive regulation of RNA metabolic process (GO:0051254) 2.513PAXIP1, PSEN1, APP
positive regulation of RNA biosynthetic process (GO:1902680) 2.543PAXIP1, APP, PSEN1
negative regulation of protein modification process (GO:0031400) 3.43SORL1, HFE, PSEN1
regulation of cell activation (GO:0050865) 3.533NOS3, PAXIP1, HFE
regulation of smooth muscle cell migration (GO:0014910) 5.843SORL1, PLAU, ACE
positive regulation of cell death (GO:0010942) 3.323PSEN2, APBB2, PSEN1
cell death (GO:0008219) 3.053PLAU, APP, PSEN1
regulation of growth (GO:0040008) 3.263MPO, APBB2, APP
negative regulation of nervous system development (GO:0051961) 4.153SORL1, PSEN1, APP
positive regulation of apoptotic process (GO:0043065) 3.383PSEN2, APBB2, PSEN1
negative regulation of peptidase activity (GO:0010466) 4.223A2M, SORL1, APP
extracellular structure organization (GO:0043062) 4.03A2M, APBB2, APP
positive regulation of programmed cell death (GO:0043068) 3.383PSEN2, APBB2, PSEN1
regulation of cell migration (GO:0030334) 3.233SORL1, PLAU, ACE
regulation of peptidase activity (GO:0052547) 3.753A2M, SORL1, APP
regulation of endopeptidase activity (GO:0052548) 3.83A2M, SORL1, APP
metal ion homeostasis (GO:0055065) 3.613APP, HFE, PSEN1
negative regulation of endopeptidase activity (GO:0010951) 4.263A2M, SORL1, APP
catabolic process (GO:0009056) 2.383MPO, NOS3, ACE
response to oxygen-containing compound (GO:1901700) 2.573MPO, PLAU, APP
regulation of locomotion (GO:0040012) 3.123SORL1, PLAU, ACE
regulation of cellular component biogenesis (GO:0044087) 3.083SORL1, PAXIP1, ACE
immune effector process (GO:0002252) 3.583MPO, ACE, PSEN1
positive regulation of protein phosphorylation (GO:0001934) 2.953ACE, HFE, PSEN1
negative regulation of apoptotic signaling pathway (GO:2001234) 4.422NOS3, PSEN1
protein localization (GO:0008104) 2.362SORL1, PSEN1
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434) 5.052HFE, PSEN1
regulation of apoptotic signaling pathway (GO:2001233) 3.832NOS3, PSEN1
regulation of systemic arterial blood pressure (GO:0003073) 5.992NOS3, ACE
tissue remodeling (GO:0048771) 5.542NOS3, ACE
behavior (GO:0007610) 3.472APP, PSEN1
learning or memory (GO:0007611) 4.332PSEN1, APP
regulation of lymphocyte mediated immunity (GO:0002706) 4.992PAXIP1, HFE
anion transport (GO:0006820) 3.712ACE, PSEN1
circulatory system process (GO:0003013) 4.382NOS3, ACE
regulation of leukocyte mediated immunity (GO:0002703) 4.72PAXIP1, HFE
calcium ion homeostasis (GO:0055074) 3.972PSEN1, APP
cellular localization (GO:0051641) 2.322SORL1, APP
regulation of production of molecular mediator of immune response (GO:0002700) 5.12PAXIP1, HFE
vascular process in circulatory system (GO:0003018) 4.652NOS3, ACE
regulation of anatomical structure size (GO:0090066) 3.782NOS3, ACE
smooth endoplasmic reticulum calcium ion homeostasis (GO:0051563) 9.042PSEN1, APP
single-organism catabolic process (GO:0044712) 3.212NOS3, ACE
hormone metabolic process (GO:0042445) 4.642ACE, HFE
stem cell differentiation (GO:0048863) 5.722A2M, ACE
developmental growth (GO:0048589) 4.052PLAU, APP
positive regulation of signal transduction (GO:0009967) 2.52HFE, PSEN1
regulation of hemostasis (GO:1900046) 5.262NOS3, PLAU
negative regulation of neuron differentiation (GO:0045665) 4.452APP, PSEN1
regulation of neuron differentiation (GO:0045664) 3.392APP, PSEN1
phosphorylation (GO:0016310) 2.632PLAU, APP
macromolecule localization (GO:0033036) 2.342SORL1, PSEN1
positive regulation of transport (GO:0051050) 2.92SORL1, HFE
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) 4.992PAXIP1, HFE
organic anion transport (GO:0015711) 4.072ACE, PSEN1
defense response to fungus (GO:0050832) 6.092MPO, APP
secondary alcohol metabolic process (GO:1902652) 5.02SORL1, APP
spermatogenesis (GO:0007283) 3.72PLAU, ACE
response to metal ion (GO:0010038) 3.912HFE, APP
oxoacid metabolic process (GO:0043436) 3.122MPO, NOS3
divalent metal ion transport (GO:0070838) 4.152PSEN2, PSEN1
response to inorganic substance (GO:0010035) 3.562HFE, APP
response to other organism (GO:0051707) 3.482MPO, APP
oxidation-reduction process (GO:0055114) 2.912MPO, NOS3
heterocycle metabolic process (GO:0046483) 1.312PAXIP1, APP
positive regulation of signaling (GO:0023056) 2.412HFE, PSEN1
negative regulation of phosphorylation (GO:0042326) 3.72SORL1, PSEN1
epithelial cell migration (GO:0010631) 5.422NOS3, PAXIP1
transition metal ion homeostasis (GO:0055076) 5.092HFE, APP
single-organism behavior (GO:0044708) 3.792APP, PSEN1
response to organonitrogen compound (GO:0010243) 3.22PLAU, APP
response to nutrient levels (GO:0031667) 3.772MPO, HFE
removal of superoxide radicals (GO:0019430) 7.242MPO, NOS3
regulation of blood coagulation (GO:0030193) 5.262NOS3, PLAU
negative regulation of blood coagulation (GO:0030195) 5.882NOS3, PLAU
positive regulation of catabolic process (GO:0009896) 3.942SORL1, PSEN1
cellular response to growth factor stimulus (GO:0071363) 4.272PLAU, APP
negative regulation of catabolic process (GO:0009895) 4.812HFE, PSEN1
positive regulation of kinase activity (GO:0033674) 3.542ACE, PSEN1
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242PSEN2, HFE
negative regulation of binding (GO:0051100) 4.852SORL1, HFE
hematopoietic progenitor cell differentiation (GO:0002244) 5.232ACE, PSEN1
negative regulation of gene expression (GO:0010629) 2.482A2M, PSEN1
neuron migration (GO:0001764) 5.02APBB2, PSEN1
superoxide metabolic process (GO:0006801) 6.232MPO, NOS3
detoxification (GO:0098754) 5.372MPO, NOS3
antigen processing and presentation of peptide antigen (GO:0048002) 4.562ACE, HFE
regulation of vasodilation (GO:0042312) 5.862NOS3, ACE
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582SORL1, PSEN1
ameboidal-type cell migration (GO:0001667) 4.712NOS3, PAXIP1
amyloid precursor protein metabolic process (GO:0042982) 7.242PSEN2, PSEN1
endothelial cell migration (GO:0043542) 5.692NOS3, PAXIP1
negative regulation of protein binding (GO:0032091) 5.362SORL1, HFE
organic substance catabolic process (GO:1901575) 2.452NOS3, ACE
response to hypoxia (GO:0001666) 4.132PSEN2, PLAU
cellular transition metal ion homeostasis (GO:0046916) 5.422HFE, APP
regulation of cellular protein catabolic process (GO:1903362) 4.232HFE, PSEN1
positive regulation of hydrolase activity (GO:0051345) 2.912A2M, APP
exocytosis (GO:0006887) 4.112A2M, APP
regulated exocytosis (GO:0045055) 4.442A2M, APP
positive regulation of immune system process (GO:0002684) 2.962PAXIP1, PSEN1
negative regulation of hemostasis (GO:1900047) 5.882NOS3, PLAU
negative regulation of immune system process (GO:0002683) 3.852A2M, HFE
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812PAXIP1, APP
regulation of MAPK cascade (GO:0043408) 3.222SORL1, PSEN1
regulation of tube size (GO:0035150) 4.792NOS3, ACE
negative regulation of receptor activity (GO:2000272) 6.42HFE, PSEN1
antigen processing and presentation (GO:0019882) 4.362ACE, HFE
lipid metabolic process (GO:0006629) 2.682SORL1, APP
regulation of ERBB signaling pathway (GO:1901184) 5.32PSEN1, APP
nucleobase-containing compound metabolic process (GO:0006139) 1.352PAXIP1, APP
tissue development (GO:0009888) 3.272PLAU, PAXIP1
calcium ion transport (GO:0006816) 4.332PSEN2, PSEN1
programmed cell death (GO:0012501) 3.12PSEN1, APP
regulation of multi-organism process (GO:0043900) 3.62MPO, PLAU
regulation of blood vessel size (GO:0050880) 4.82NOS3, ACE
regulation of blood circulation (GO:1903522) 4.052NOS3, ACE
negative regulation of transferase activity (GO:0051348) 3.872SORL1, PSEN1
secretion by cell (GO:0032940) 3.592A2M, APP
immune response (GO:0006955) 2.862HFE, APP
regulation of protein complex assembly (GO:0043254) 3.832SORL1, PAXIP1
negative regulation of neuron death (GO:1901215) 4.572SORL1, PSEN1
negative regulation of coagulation (GO:0050819) 5.822NOS3, PLAU
endocrine process (GO:0050886) 6.432NOS3, ACE
RNA metabolic process (GO:0016070) 1.592PAXIP1, APP
Notch receptor processing (GO:0007220) 6.92PSEN2, PSEN1
endocytosis (GO:0006897) 3.692SORL1, APP
intracellular transport (GO:0046907) 2.672SORL1, APP
response to decreased oxygen levels (GO:0036293) 4.092PSEN2, PLAU
response to nitrogen compound (GO:1901698) 3.122PLAU, APP
cellular response to nitrogen compound (GO:1901699) 3.792PLAU, APP
cognition (GO:0050890) 4.22PSEN1, APP
blood vessel remodeling (GO:0001974) 6.232NOS3, ACE
response to yeast (GO:0001878) 7.162MPO, APP
negative regulation of immune effector process (GO:0002698) 5.12A2M, HFE
organonitrogen compound catabolic process (GO:1901565) 3.912NOS3, ACE
negative regulation of kinase activity (GO:0033673) 4.222SORL1, PSEN1
negative regulation of response to external stimulus (GO:0032102) 4.182NOS3, PLAU
lipid transport (GO:0006869) 4.242SORL1, ACE
regulation of synapse structure or activity (GO:0050803) 4.772APP, PSEN1
response to radiation (GO:0009314) 3.692PAXIP1, APP
regulation of cell adhesion (GO:0030155) 3.272PLAU, HFE
membrane protein proteolysis (GO:0033619) 6.172PSEN2, PSEN1
regulation of adaptive immune response (GO:0002819) 4.912PAXIP1, HFE
response to growth factor (GO:0070848) 4.142PLAU, APP
regulation of cellular protein localization (GO:1903827) 3.432SORL1, HFE
cellular biosynthetic process (GO:0044249) 1.372NOS3, PAXIP1
regulation of MAP kinase activity (GO:0043405) 3.952SORL1, PSEN1
negative regulation of protein catabolic process (GO:0042177) 5.242HFE, PSEN1
positive regulation of cell communication (GO:0010647) 2.412HFE, PSEN1
anatomical structure morphogenesis (GO:0009653) 2.532PSEN1, APP
regulation of neuron death (GO:1901214) 4.192SORL1, PSEN1
response to organic cyclic compound (GO:0014070) 3.072PLAU, APP
regulation of protein localization (GO:0032880) 2.882SORL1, HFE
response to endogenous stimulus (GO:0009719) 2.792PLAU, APP
cellular oxidant detoxification (GO:0098869) 5.452MPO, NOS3
regulation of lymphocyte activation (GO:0051249) 3.732PAXIP1, HFE
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962PSEN1, APP
regulation of system process (GO:0044057) 3.532NOS3, ACE
negative regulation of phosphorus metabolic process (GO:0010563) 3.452SORL1, PSEN1
regeneration (GO:0031099) 4.72PLAU, HFE
divalent inorganic cation homeostasis (GO:0072507) 3.92APP, PSEN1
negative regulation of protein modification by small protein conjugation or removal (GO:1903321) 4.82HFE, PSEN1
membrane protein ectodomain proteolysis (GO:0006509) 6.642PSEN2, PSEN1
negative regulation of protein ubiquitination (GO:0031397) 4.872HFE, PSEN1
biological adhesion (GO:0022610) 2.812APP, PSEN1
regulation of response to wounding (GO:1903034) 4.742NOS3, PLAU
negative regulation of response to wounding (GO:1903035) 5.542NOS3, PLAU
cellular response to endogenous stimulus (GO:0071495) 3.332PLAU, APP
sterol metabolic process (GO:0016125) 4.922SORL1, APP
regulation of body fluid levels (GO:0050878) 3.762NOS3, PLAU
cell proliferation (GO:0008283) 3.232ACE, PSEN1
establishment of protein localization (GO:0045184) 2.532SORL1, PSEN1
neurological system process (GO:0050877) 2.642APP, PSEN1
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050) 4.322HFE, PSEN1
negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051) 6.072HFE, PSEN1
cellular aromatic compound metabolic process (GO:0006725) 1.32PAXIP1, APP
reactive oxygen species metabolic process (GO:0072593) 5.142MPO, NOS3
regulation of vesicle-mediated transport (GO:0060627) 3.632SORL1, HFE
cellular response to DNA damage stimulus (GO:0006974) 3.172PAXIP1, PSEN1
defense response to other organism (GO:0098542) 3.752MPO, APP
male gamete generation (GO:0048232) 3.72PLAU, ACE
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592NOS3, PAXIP1
steroid metabolic process (GO:0008202) 4.322SORL1, APP
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) 6.362NOS3, ACE
negative regulation of immune response (GO:0050777) 4.942A2M, HFE
divalent inorganic cation transport (GO:0072511) 4.132PSEN2, PSEN1
organic acid metabolic process (GO:0006082) 3.012MPO, NOS3
cellular response to organic cyclic compound (GO:0071407) 3.932PLAU, APP
regulation of cell cycle (GO:0051726) 2.932APBB2, APP
positive regulation of immune response (GO:0050778) 3.42PAXIP1, PSEN1
response to molecule of bacterial origin (GO:0002237) 3.992MPO, PLAU
regulation of cellular catabolic process (GO:0031329) 3.832HFE, PSEN1
response to fluid shear stress (GO:0034405) 6.22NOS3, PLAU
positive regulation of proteolysis (GO:0045862) 3.862PSEN1, APP
gland development (GO:0048732) 4.152HFE, PSEN1
positive regulation of protein catabolic process (GO:0045732) 4.182SORL1, PSEN1
response to extracellular stimulus (GO:0009991) 3.712MPO, HFE
negative regulation of growth (GO:0045926) 4.242MPO, APBB2
regulation of cellular localization (GO:0060341) 3.032SORL1, HFE
response to transition metal nanoparticle (GO:1990267) 4.72MPO, HFE
negative regulation of cell activation (GO:0050866) 4.672NOS3, HFE
regulation of epidermal growth factor receptor signaling pathway (GO:0042058) 5.332APP, PSEN1
nucleic acid metabolic process (GO:0090304) 1.462PAXIP1, APP
regulation of wound healing (GO:0061041) 4.882NOS3, PLAU
regulation of blood pressure (GO:0008217) 4.722NOS3, ACE
negative regulation of wound healing (GO:0061045) 5.652NOS3, PLAU
angiogenesis (GO:0001525) 4.152NOS3, PLAU
amyloid precursor protein catabolic process (GO:0042987) 7.652PSEN2, PSEN1
gamete generation (GO:0007276) 3.612PLAU, ACE
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) 5.192ACE, HFE
cholesterol metabolic process (GO:0008203) 5.032SORL1, APP
growth (GO:0040007) 3.82PLAU, APP
regulation of leukocyte activation (GO:0002694) 3.62PAXIP1, HFE
response to lipid (GO:0033993) 3.112MPO, PLAU
platelet degranulation (GO:0002576) 5.122A2M, APP
positive regulation of protein kinase activity (GO:0045860) 3.612ACE, PSEN1
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2000059) 7.652HFE, PSEN1
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2000058) 5.122HFE, PSEN1
negative regulation of cellular catabolic process (GO:0031330) 5.382HFE, PSEN1
cellular response to organic substance (GO:0071310) 2.782PLAU, APP
endoplasmic reticulum calcium ion homeostasis (GO:0032469) 6.732APP, PSEN1
regulation of ion transport (GO:0043269) 3.42NOS3, HFE
negative regulation of phosphate metabolic process (GO:0045936) 3.452SORL1, PSEN1
cellular calcium ion homeostasis (GO:0006874) 4.012APP, PSEN1
negative regulation of protein kinase activity (GO:0006469) 4.292SORL1, PSEN1
response to oxygen levels (GO:0070482) 4.022PSEN2, PLAU
negative regulation of cellular protein catabolic process (GO:1903363) 5.922HFE, PSEN1
regulation of proteasomal protein catabolic process (GO:0061136) 4.782HFE, PSEN1
apoptotic process (GO:0006915) 3.142PSEN1, APP
regulation of hormone levels (GO:0010817) 3.562ACE, HFE
regulation of metal ion transport (GO:0010959) 3.942NOS3, HFE
neuron apoptotic process (GO:0051402) 6.152PSEN1, APP
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472SORL1, PSEN1
establishment of localization in cell (GO:0051649) 2.472SORL1, APP
cell adhesion (GO:0007155) 2.822PSEN1, APP
regulation of cellular amide metabolic process (GO:0034248) 3.882SORL1, APP
carboxylic acid transport (GO:0046942) 4.282ACE, PSEN1
organelle organization (GO:0006996) 2.022NOS3, PSEN1
cellular response to oxygen-containing compound (GO:1901701) 3.222PLAU, APP
regulation of systemic arterial blood pressure by hormone (GO:0001990) 6.432NOS3, ACE
regulation of epidermal growth factor-activated receptor activity (GO:0007176) 6.592APP, PSEN1
response to fungus (GO:0009620) 5.842MPO, APP
cellular detoxification (GO:1990748) 5.412MPO, NOS3
alcohol metabolic process (GO:0006066) 4.22SORL1, APP
phosphate-containing compound metabolic process (GO:0006796) 2.162PLAU, APP
forebrain development (GO:0030900) 5.482PSEN1, APP
phosphorus metabolic process (GO:0006793) 2.152PLAU, APP
protein transport (GO:0015031) 2.622SORL1, PSEN1
negative regulation of protein phosphorylation (GO:0001933) 3.792SORL1, PSEN1
organic hydroxy compound metabolic process (GO:1901615) 3.842SORL1, APP
response to lipopolysaccharide (GO:0032496) 4.032MPO, PLAU
cellular response to organonitrogen compound (GO:0071417) 3.872PLAU, APP

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of apoptotic signaling pathway (GO:2001234) -4.420.004NOS3, PLAU, PSEN1, A2M, PSEN2, APP
regulation of extrinsic apoptotic signaling pathway (GO:2001236) NEW4.690.002NOS3, PLAU, PSEN1, A2M, PSEN2, APP
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) NEW5.130.0NOS3, PLAU, PSEN1, A2M, PSEN2, APP
regulation of response to stimulus (GO:0048583) -1.540.043NOS3, SORL1, PSEN1, A2M, PAXIP1, HFE, PSEN2, PLAU, APP
hair cycle phase (GO:0044851) NEW9.040.004PSEN2, APP, PSEN1
smooth endoplasmic reticulum calcium ion homeostasis (GO:0051563) -9.040.0PSEN1, APP
taxis (GO:0042330) NEW4.030.021NOS3, PLAU, PSEN1, APP, A2M, ACE
positive regulation of immune system process (GO:0002684) -2.960.0MPO, NOS3, PLAU, PSEN1, PSEN2, APP, PAXIP1, HFE, A2M, ACE
negative regulation of molecular function (GO:0044092) -2.740.021NOS3, SORL1, PSEN1, A2M, PSEN2, APP
chemotaxis (GO:0006935) NEW4.040.021NOS3, PLAU, PSEN1, ACE, A2M, APP
negative regulation of cell death (GO:0060548) -2.950.001MPO, NOS3, SORL1, PSEN1, A2M, APBB2, APP, PSEN2, PLAU, ACE
regulation of epidermal growth factor-activated receptor activity (GO:0007176) -6.590.001PSEN2, APP, PSEN1
response to metal ion (GO:0010038) -3.910.001NOS3, PLAU, PSEN1, A2M, ACE, PSEN2, APP
response to inorganic substance (GO:0010035) -3.560.0MPO, NOS3, PLAU, PAXIP1, PSEN2, APP, PSEN1, A2M, ACE
vesicle-mediated transport (GO:0016192) -2.720.022MPO, NOS3, SORL1, PSEN1, PSEN2, HFE, A2M, PLAU, APP
regulation of biological quality (GO:0065008) -1.680.01NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
epithelial cell migration (GO:0010631) -5.420.027NOS3, PAXIP1, ACE, APP
single-multicellular organism process (GO:0044707) -1.780.038MPO, NOS3, PLAU, PSEN1, A2M, APP, HFE, PSEN2, ACE
cell motility (GO:0048870) -3.020.006NOS3, SORL1, APP, PSEN1, APBB2, PAXIP1, A2M, PLAU, ACE
negative regulation of programmed cell death (GO:0043069) -3.020.007MPO, NOS3, PLAU, PSEN1, PSEN2, APBB2, ACE, A2M, APP
positive regulation of programmed cell death (GO:0043068) -3.380.0NOS3, PLAU, PAXIP1, A2M, APBB2, PSEN1, PSEN2, APP, ACE
extracellular matrix organization (GO:0030198) -4.010.0NOS3, PLAU, PSEN1, A2M, APBB2, HFE, PSEN2, APP
regulation of blood coagulation (GO:0030193) -5.260.045A2M, NOS3, PLAU, APP
regulation of beta-amyloid formation (GO:1902003) NEW7.530.001SORL1, PSEN1, APP
negative regulation of blood coagulation (GO:0030195) -5.880.001A2M, NOS3, PLAU, APP
response to oxygen radical (GO:0000305) NEW7.650.004MPO, NOS3, APP
response to superoxide (GO:0000303) NEW7.780.003MPO, NOS3, APP
cellular component movement (GO:0006928) -2.610.01NOS3, SORL1, PAXIP1, APBB2, PSEN1, PLAU, APP
positive regulation of coagulation (GO:0050820) NEW6.510.016PSEN2, PSEN1, APP
amyloid precursor protein catabolic process (GO:0042987) -7.650.017PSEN2, PSEN1
amyloid precursor protein metabolic process (GO:0042982) -7.240.001PSEN2, APP, PSEN1
regulation of systemic arterial blood pressure (GO:0003073) -5.990.05NOS3, ACE, APP
response to hypoxia (GO:0001666) -4.130.002NOS3, PLAU, PSEN1, A2M, ACE, PSEN2, APP
regulation of hemostasis (GO:1900046) -5.260.045A2M, NOS3, PLAU, APP
negative regulation of hemostasis (GO:1900047) -5.880.001A2M, NOS3, PLAU, APP
regulation of protein tyrosine kinase activity (GO:0061097) -5.590.007PSEN2, PSEN1, APP
cell migration (GO:0016477) -3.120.003NOS3, SORL1, PSEN1, PAXIP1, APBB2, APP, A2M, PLAU, ACE
cell activation (GO:0001775) NEW3.470.028NOS3, PLAU, PSEN1, A2M, ACE, HFE, PSEN2, APP
regulation of protein binding (GO:0043393) -4.60.002PSEN2, SORL1, PSEN1, NOS3, APP
regulation of multicellular organismal process (GO:0051239) -1.870.024NOS3, SORL1, PSEN1, PAXIP1, APP, PSEN2, PLAU, ACE
regulation of coagulation (GO:0050818) -5.220.0NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
negative regulation of coagulation (GO:0050819) -5.820.0A2M, NOS3, PLAU, HFE, APP
leukocyte differentiation (GO:0002521) NEW4.130.031PLAU, PSEN1, A2M, ACE, PSEN2, APP
endocytosis (GO:0006897) -3.690.0MPO, NOS3, SORL1, PSEN1, PSEN2, A2M, PLAU, APP
protein maturation (GO:0051604) -4.480.014NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
response to decreased oxygen levels (GO:0036293) -4.090.002NOS3, PLAU, PSEN1, A2M, APP, PSEN2, ACE
regulation of leukocyte activation (GO:0002694) -3.60.029NOS3, PLAU, PSEN1, PAXIP1, ACE, A2M, APP
peptide metabolic process (GO:0006518) -3.440.04PSEN2, ACE, NOS3, PSEN1, APP
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042) NEW6.20.02PSEN2, NOS3, PLAU
lipid transport (GO:0006869) -4.240.001NOS3, SORL1, APP, A2M, PLAU, ACE
regulation of amyloid precursor protein catabolic process (GO:1902991) NEW7.330.001SORL1, APP, PSEN1
regulation of Rho protein signal transduction (GO:0035023) NEW5.020.048A2M, NOS3, APP
beta-amyloid metabolic process (GO:0050435) -7.090.001PSEN2, PSEN1, APP
anagen (GO:0042640) NEW9.730.025PSEN2, PSEN1
regulation of cellular response to growth factor stimulus (GO:0090287) NEW4.290.002NOS3, PLAU, PSEN1, ACE, A2M, APP
positive regulation of multicellular organismal process (GO:0051240) -2.490.04NOS3, PLAU, PSEN1, PAXIP1, A2M, ACE, PSEN2, APP
negative regulation of multicellular organismal process (GO:0051241) -2.840.045MPO, NOS3, PLAU, PAXIP1, HFE, A2M, APP
positive regulation of protein metabolic process (GO:0051247) -2.430.013MPO, NOS3, HFE, SORL1, PSEN1, APP, PAXIP1, A2M, PLAU, ACE
membrane protein ectodomain proteolysis (GO:0006509) -6.640.004PSEN2, APP, PSEN1
proteolysis (GO:0006508) -2.730.014NOS3, PLAU, BLMH, PSEN1, A2M, ACE, HFE, PSEN2, APP
extracellular matrix disassembly (GO:0022617) NEW5.380.004PSEN2, A2M, NOS3, APP, PSEN1
striated muscle cell development (GO:0055002) NEW5.420.029BLMH, NOS3, PSEN1, APP
multicellular organismal process (GO:0032501) -1.450.045MPO, NOS3, PLAU, PSEN1, PSEN2, APP, HFE, A2M, ACE
response to abiotic stimulus (GO:0009628) -2.80.008MPO, NOS3, HFE, PLAU, PSEN1, A2M, ACE, PAXIP1, PSEN2, APP
regulation of cellular amide metabolic process (GO:0034248) -3.880.004SORL1, APP, PSEN1
protein processing (GO:0016485) -4.620.004NOS3, PSEN1, A2M, ACE, PSEN2, APP
cellular chemical homeostasis (GO:0055082) -3.40.027NOS3, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
response to reactive oxygen species (GO:0000302) NEW4.50.022MPO, NOS3, PAXIP1, ACE, APP
response to oxidative stress (GO:0006979) -3.90.003MPO, NOS3, PAXIP1, APP, PSEN1, HFE, ACE
regulation of immune response (GO:0050776) -2.980.0MPO, NOS3, HFE, PLAU, PSEN1, A2M, ACE, PAXIP1, PSEN2, APP
cellular amide metabolic process (GO:0043603) -3.230.009PSEN2, ACE, NOS3, PSEN1, APP
leukocyte activation (GO:0045321) NEW3.760.032NOS3, PLAU, PSEN1, A2M, APP, PSEN2, ACE
regulation of binding (GO:0051098) -4.080.015NOS3, SORL1, PSEN1, PSEN2, PLAU, APP
negative regulation of angiogenesis (GO:0016525) NEW5.420.045A2M, NOS3, PSEN1, APP
negative regulation of growth (GO:0045926) -4.240.029MPO, NOS3, PSEN1, APBB2, A2M, APP
dorsal/ventral neural tube patterning (GO:0021904) NEW7.090.048PSEN2, PSEN1
regulation of smooth muscle cell migration (GO:0014910) -5.840.001SORL1, PLAU, ACE, APP
apoptotic signaling pathway (GO:0097190) NEW4.120.004NOS3, PLAU, PAXIP1, A2M, PSEN1, PSEN2, APP
regulation of epidermal growth factor receptor signaling pathway (GO:0042058) -5.330.016PSEN2, APP, PSEN1
positive regulation of cell death (GO:0010942) -3.320.0NOS3, PLAU, PSEN1, A2M, APBB2, ACE, PAXIP1, PSEN2, APP
regulation of ERBB signaling pathway (GO:1901184) -5.30.018PSEN2, PSEN1, APP
pattern specification process (GO:0007389) NEW3.790.033NOS3, PLAU, PAXIP1, A2M, PSEN1, PSEN2, APP
response to lipid (GO:0033993) -3.110.007MPO, NOS3, PLAU, PSEN1, APP, PAXIP1, HFE, A2M, ACE
angiotensin maturation (GO:0002003) NEW7.330.004NOS3, ACE, APP
positive regulation of apoptotic process (GO:0043065) -3.380.0NOS3, PLAU, PSEN1, PAXIP1, A2M, APBB2, ACE, PSEN2, APP
hematopoietic progenitor cell differentiation (GO:0002244) -5.230.048PSEN2, ACE, PSEN1
negative regulation of apoptotic process (GO:0043066) -3.040.006MPO, NOS3, PLAU, PSEN1, A2M, APBB2, APP, PSEN2, ACE
endoplasmic reticulum calcium ion homeostasis (GO:0032469) -6.730.0PSEN2, APP, PSEN1
extracellular structure organization (GO:0043062) -4.00.0NOS3, PLAU, PSEN1, A2M, APBB2, HFE, PSEN2, APP
regulation of receptor activity (GO:0010469) -4.980.0PSEN2, NOS3, PLAU, APP, PSEN1
regulation of macrophage derived foam cell differentiation (GO:0010743) NEW6.40.035A2M, NOS3, APP
biological phase (GO:0044848) NEW4.370.034PSEN2, APP, PSEN1
response to oxygen levels (GO:0070482) -4.020.003NOS3, PLAU, PSEN1, A2M, APP, PSEN2, ACE
locomotion (GO:0040011) -2.910.001NOS3, SORL1, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, PLAU, ACE
heart development (GO:0007507) NEW4.240.003NOS3, PLAU, PSEN1, ACE, A2M, APP
regulation of cellular component biogenesis (GO:0044087) -3.080.01NOS3, SORL1, PSEN1, A2M, PAXIP1, PSEN2, PLAU, APP
regulation of organ morphogenesis (GO:2000027) NEW4.220.048A2M, NOS3, PAXIP1, ACE, APP
immune effector process (GO:0002252) -3.580.031MPO, NOS3, PSEN1, A2M, APP, PSEN2, ACE
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane-bounded organelle (GO:0043227) 0.4713MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
cell part (GO:0044464) 0.1113MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, A2M, APBB2, APP, HFE, PSEN2, PLAU, ACE
organelle (GO:0043226) 0.413MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
intracellular part (GO:0044424) 0.2812MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APBB2, APP, PAXIP1, PSEN2, ACE
intracellular organelle (GO:0043229) 0.5111MPO, NOS3, SORL1, BLMH, PSEN1, APBB2, PAXIP1, HFE, PSEN2, APP, ACE
intracellular membrane-bounded organelle (GO:0043231) 0.611MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, APBB2, APP, HFE, PSEN2, ACE
cytoplasmic part (GO:0044444) 0.8210MPO, NOS3, SORL1, BLMH, PSEN1, PSEN2, APP, HFE, A2M, ACE
membrane (GO:0016020) 0.689NOS3, SORL1, PSEN1, APBB2, APP, HFE, PSEN2, PLAU, ACE
vesicle (GO:0031982) 1.649MPO, BLMH, SORL1, PSEN1, APP, HFE, A2M, PLAU, ACE
intracellular organelle part (GO:0044446) 0.818NOS3, SORL1, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
extracellular region part (GO:0044421) 1.578MPO, BLMH, SORL1, ACE, HFE, A2M, PLAU, APP
organelle part (GO:0044422) 0.798NOS3, SORL1, PAXIP1, A2M, PSEN1, HFE, PSEN2, APP
extracellular organelle (GO:0043230) 1.897MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
extracellular space (GO:0005615) 2.637MPO, SORL1, ACE, HFE, A2M, PLAU, APP
membrane-bounded vesicle (GO:0031988) 1.717MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
plasma membrane (GO:0005886) 1.397NOS3, PLAU, PSEN1, ACE, HFE, PSEN2, APP
membrane part (GO:0044425) 0.957NOS3, SORL1, PSEN1, APP, HFE, PSEN2, ACE
extracellular vesicle (GO:1903561) 1.897MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
plasma membrane part (GO:0044459) 1.957NOS3, SORL1, PSEN1, APP, HFE, PSEN2, ACE
extracellular exosome (GO:0070062) 1.897MPO, BLMH, SORL1, ACE, A2M, PLAU, APP
cytoplasm (GO:0005737) 1.016NOS3, BLMH, APBB2, ACE, PSEN2, APP
integral component of membrane (GO:0016021) 1.146SORL1, PSEN1, ACE, HFE, PSEN2, APP
macromolecular complex (GO:0032991) 1.356SORL1, PSEN1, PAXIP1, HFE, PSEN2, APP
nucleus (GO:0005634) 1.076MPO, BLMH, NOS3, PAXIP1, APBB2, PSEN1
intrinsic component of membrane (GO:0031224) 1.136SORL1, PSEN1, ACE, HFE, PSEN2, APP
protein complex (GO:0043234) 1.515PSEN2, PAXIP1, PSEN1, HFE, APP
Golgi apparatus (GO:0005794) 2.75PSEN2, SORL1, PSEN1, NOS3, APP
vacuole (GO:0005773) 2.925MPO, ACE, SORL1, HFE, APP
Golgi apparatus part (GO:0044431) 3.05PSEN2, SORL1, PSEN1, NOS3, APP
extracellular region (GO:0005576) 2.185A2M, SORL1, PLAU, ACE, APP
nuclear part (GO:0044428) 1.555PSEN2, SORL1, PAXIP1, PSEN1, APP
integral component of plasma membrane (GO:0005887) 2.575PSEN2, SORL1, PSEN1, HFE, APP
intrinsic component of plasma membrane (GO:0031226) 2.535PSEN2, SORL1, PSEN1, HFE, APP
endoplasmic reticulum (GO:0005783) 2.564PSEN2, SORL1, PSEN1, APP
intracellular non-membrane-bounded organelle (GO:0043232) 1.764PSEN2, NOS3, HFE, PSEN1
cytoplasmic vesicle (GO:0031410) 2.874MPO, APP, HFE, PSEN1
bounding membrane of organelle (GO:0098588) 2.394PSEN2, NOS3, PSEN1, APP
Golgi membrane (GO:0000139) 3.284PSEN2, NOS3, APP, PSEN1
neuron part (GO:0097458) 2.644PSEN2, APBB2, PSEN1, APP
non-membrane-bounded organelle (GO:0043228) 1.764PSEN2, NOS3, HFE, PSEN1
intracellular vesicle (GO:0097708) 2.864MPO, PSEN1, HFE, APP
cytoskeletal part (GO:0044430) 2.494PSEN2, APP, HFE, PSEN1
endosome (GO:0005768) 3.254ACE, SORL1, HFE, APP
cytosol (GO:0005829) 1.684A2M, NOS3, BLMH, APP
organelle membrane (GO:0031090) 1.974PSEN2, NOS3, PSEN1, APP
membrane microdomain (GO:0098857) 4.173NOS3, PSEN1, APP
cell projection part (GO:0044463) 2.973APBB2, APP, PSEN1
organelle lumen (GO:0043233) 3.053A2M, SORL1, APP
cell surface (GO:0009986) 3.443PLAU, PSEN1, APP
membrane region (GO:0098589) 3.953NOS3, PSEN1, APP
site of polarized growth (GO:0030427) 4.853APBB2, PSEN1, APP
growth cone (GO:0030426) 4.893APBB2, APP, PSEN1
membrane-enclosed lumen (GO:0031974) 3.053A2M, SORL1, APP
cytoplasmic vesicle part (GO:0044433) 3.413A2M, NOS3, APP
intracellular organelle lumen (GO:0070013) 3.053A2M, SORL1, APP
synapse (GO:0045202) 3.583APBB2, PSEN1, APP
perinuclear region of cytoplasm (GO:0048471) 3.353PSEN2, HFE, APP
cell projection (GO:0042995) 2.473APBB2, APP, PSEN1
cell junction (GO:0030054) 2.753PLAU, APP, PSEN1
membrane raft (GO:0045121) 4.183NOS3, APP, PSEN1
plasma membrane region (GO:0098590) 2.972PSEN2, NOS3
lytic vacuole (GO:0000323) 3.892MPO, ACE
external side of plasma membrane (GO:0009897) 4.462ACE, HFE
organelle envelope lumen (GO:0031970) 5.412SORL1, APP
side of membrane (GO:0098552) 4.222ACE, HFE
endoplasmic reticulum membrane (GO:0005789) 2.952PSEN2, PSEN1
neuromuscular junction (GO:0031594) 5.812APP, PSEN1
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 5.192A2M, APP
cytoskeleton (GO:0005856) 2.552NOS3, HFE
lysosome (GO:0005764) 3.892MPO, ACE
apical part of cell (GO:0045177) 5.342HFE, APP
vesicle lumen (GO:0031983) 5.172A2M, APP
platelet alpha granule lumen (GO:0031093) 5.812A2M, APP
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122MPO, APP
centrosome (GO:0005813) 3.752PSEN2, PSEN1
whole membrane (GO:0098805) 2.852NOS3, PSEN1
mitochondrion (GO:0005739) 2.422MPO, PSEN1
microtubule organizing center (GO:0005815) 3.422PSEN2, PSEN1
endoplasmic reticulum part (GO:0044432) 2.732PSEN2, PSEN1
synapse part (GO:0044456) 3.422PSEN1, APP
vacuolar part (GO:0044437) 3.262APP, PSEN1
neuron projection (GO:0043005) 3.122APP, PSEN1
neuronal cell body (GO:0043025) 3.92PSEN2, PSEN1
recycling endosome (GO:0055037) 5.112SORL1, HFE
rough endoplasmic reticulum (GO:0005791) 5.832PSEN1, APP
smooth endoplasmic reticulum (GO:0005790) 6.582APP, PSEN1
ciliary rootlet (GO:0035253) 7.52APP, PSEN1
cell body (GO:0044297) 3.742PSEN2, PSEN1
nuclear membrane (GO:0031965) 4.22PSEN2, PSEN1
lamellipodium (GO:0030027) 4.732APBB2, APP
secretory granule lumen (GO:0034774) 5.382A2M, APP
axon (GO:0030424) 4.152APP, PSEN1
kinetochore (GO:0000776) 5.052PSEN2, PSEN1
receptor complex (GO:0043235) 4.012HFE, APP
dendritic shaft (GO:0043198) 6.162PSEN1, APP
nuclear envelope lumen (GO:0005641) 7.722SORL1, APP
organelle inner membrane (GO:0019866) 3.562PSEN2, PSEN1
intracellular (GO:0005622) 2.372PSEN2, PSEN1
plasma membrane protein complex (GO:0098797) 3.552HFE, PSEN1
membrane protein complex (GO:0098796) 2.842HFE, PSEN1
presynapse (GO:0098793) 4.972APP, PSEN1
ciliary part (GO:0044441) 4.052APP, PSEN1
chromosomal part (GO:0044427) 3.182PSEN2, PSEN1
early endosome (GO:0005769) 4.342SORL1, HFE

NET-GE enrichment

Term New enriched termICP valueGenes
lytic vacuole (GO:0000323) -3.890.021MPO, NOS3, PAXIP1, PLAU, APP
endoplasmic reticulum (GO:0005783) -2.560.001MPO, NOS3, SORL1, PSEN1, A2M, HFE, PSEN2, PLAU, APP
site of polarized growth (GO:0030427) -4.850.001PSEN2, APBB2, NOS3, PSEN1, APP
growth cone (GO:0030426) -4.890.001PSEN2, APBB2, NOS3, APP, PSEN1
endoplasmic reticulum membrane (GO:0005789) -2.950.04NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
neuromuscular junction (GO:0031594) -5.810.001PSEN2, NOS3, APP, PSEN1
extracellular matrix part (GO:0044420) NEW4.970.024A2M, NOS3, PSEN1, APP
synapse (GO:0045202) -3.580.002PSEN2, APBB2, PLAU, PSEN1, APP
side of membrane (GO:0098552) -4.220.046NOS3, PLAU, PSEN1, ACE, APP
membrane-bounded organelle (GO:0043227) -0.470.035MPO, NOS3, SORL1, PSEN1, BLMH, PAXIP1, PSEN2, APBB2, APP, HFE, A2M, PLAU, ACE
extracellular space (GO:0005615) -2.630.003MPO, NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
endoplasmic reticulum part (GO:0044432) -2.730.037MPO, NOS3, PLAU, PSEN1, PSEN2, HFE, A2M, APP
vacuole (GO:0005773) -2.920.036MPO, NOS3, PAXIP1, PLAU, APP
cytoplasmic vesicle (GO:0031410) -2.870.016MPO, NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
multivesicular body (GO:0005771) NEW6.620.002SORL1, PSEN1, APP
blood microparticle (GO:0072562) NEW4.880.043A2M, NOS3, PLAU, APP
neuron part (GO:0097458) -2.640.036PSEN2, APBB2, SORL1, PSEN1, APP
Golgi apparatus part (GO:0044431) -3.00.001NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, PLAU, ACE
perinuclear region of cytoplasm (GO:0048471) -3.350.038NOS3, PLAU, PSEN1, A2M, HFE, PSEN2, APP
plasma membrane part (GO:0044459) -1.950.044NOS3, SORL1, PSEN1, APP, HFE, PSEN2, ACE
apical plasma membrane (GO:0016324) NEW4.130.004NOS3, PLAU, PSEN1, HFE, PSEN2, APP
Golgi apparatus (GO:0005794) -2.70.014NOS3, SORL1, PSEN1, A2M, APP, HFE, PSEN2, ACE
ciliary rootlet (GO:0035253) -7.50.0PSEN2, APP, PSEN1
secretory granule (GO:0030141) NEW4.340.012MPO, A2M, NOS3, PLAU, APP
cell surface (GO:0009986) -3.440.001NOS3, SORL1, PSEN1, A2M, HFE, PSEN2, PLAU, APP
cell cortex (GO:0005938) NEW4.780.001PSEN2, NOS3, PLAU, APP, PSEN1
axon (GO:0030424) -4.150.033PSEN2, APP, PSEN1
vesicle (GO:0031982) -1.640.006MPO, NOS3, HFE, SORL1, BLMH, PSEN1, A2M, APP, PAXIP1, PSEN2, PLAU, ACE
receptor complex (GO:0043235) -4.010.036A2M, NOS3, PLAU, PSEN1, APP
dendritic shaft (GO:0043198) -6.160.011PSEN2, PSEN1, APP
nuclear envelope lumen (GO:0005641) -7.720.003SORL1, APP
membrane raft (GO:0045121) -4.180.001PSEN2, NOS3, APP, PSEN1
lysosome (GO:0005764) -3.890.021MPO, NOS3, PAXIP1, PLAU, APP
cytoplasmic membrane-bounded vesicle (GO:0016023) -3.120.005MPO, NOS3, PLAU, PSEN1, PSEN2, HFE, A2M, APP
extracellular region (GO:0005576) -2.180.047MPO, NOS3, PLAU, PSEN1, PSEN2, ACE, HFE, A2M, APP
endosome (GO:0005768) -3.250.043SORL1, PSEN1, ACE, HFE, PLAU, APP