Disease table of EPILEPSY, NOCTURNAL FRONTAL LOBE OMIM ID: PS600513

Gene-disease associations table

GeneAssociated with EPILEPSY, NOCTURNAL FRONTAL LOBE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CHRNA4ClinVar, OMIM, HUMSAVARHGNC link20q13.332PS600513, 188890
KCNT1ClinVar, OMIM, HUMSAVARHGNC link9q34.33PS600513, PS607596, PS308350
CHRNB2ClinVar, OMIM, HUMSAVARHGNC link1q21.31PS600513
CHRNA2ClinVar, OMIM, HUMSAVARHGNC link8p21.21PS600513
SPAG1ClinVarHGNC link8q22.22PS600513, PS244400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
82SPAG1, CHRNA2
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CHRNA4CHRNB2Yesbinding11CHRNA3, CHRNA2, CHRNB3, CHRNA5, CHRNA6, JAK2, CHRNB4, CHRNB1, CHRNA7, CHRND, CHRNE
CHRNA4CHRNA2Yesbinding10CHRNA3, CHRNB2, CHRNB4, CHRNA5, CHRNA6, CHRNB3, CHRNB1, CHRNA7, CHRND, CHRNE
CHRNB2CHRNA2Yesbinding10CHRNA4, CHRNA3, CHRNB4, CHRNA5, CHRNA6, CHRNB3, CHRNB1, CHRNA7, CHRND, CHRNE

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
CHRNA4CHRNB2YesVILIP-1-AChR-alpha-4-AChR-beta-2 complex1VSNL1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Neuroactive ligand-receptor interactionhsa040804.583CHRNA4, CHRNA2, CHRNB2
Nicotine addictionhsa050337.382CHRNA4, CHRNB2
Cholinergic synapsehsa047255.882CHRNA4, CHRNB2

NET-GE enrichment

Term New enriched termICP valueGenes
Nicotine addiction (hsa05033) -7.380.001CHRNA4, CHRNB2
Signaling molecules and interactionNEW3.090.016CHRNA4, CHRNA2, CHRNB2
Neuroactive ligand-receptor interaction (hsa04080) -4.580.001CHRNA4, CHRNA2, CHRNB2
Cholinergic synapse (hsa04725) -5.880.008CHRNA4, CHRNB2
Substance dependenceNEW4.770.039CHRNA4, CHRNB2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Acetylcholine Binding And Downstream EventsR-HSA-1814319.183CHRNA4, CHRNA2, CHRNB2
Activation of Nicotinic Acetylcholine ReceptorsR-HSA-6296029.183CHRNA4, CHRNA2, CHRNB2
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-6295979.813CHRNA4, CHRNA2, CHRNB2
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-6295949.523CHRNA4, CHRNA2, CHRNB2
Postsynaptic nicotinic acetylcholine receptorsR-HSA-6223279.183CHRNA4, CHRNA2, CHRNB2
Presynaptic nicotinic acetylcholine receptorsR-HSA-6223239.43CHRNA4, CHRNA2, CHRNB2
Neuronal SystemR-HSA-1123164.823CHRNA4, CHRNA2, CHRNB2
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.853CHRNA4, CHRNA2, CHRNB2
Transmission across Chemical SynapsesR-HSA-1123155.283CHRNA4, CHRNA2, CHRNB2
Highly sodium permeable acetylcholine nicotinic receptorsR-HSA-62958710.182CHRNA4, CHRNB2

NET-GE enrichment

Term New enriched termICP valueGenes
Acetylcholine Binding And Downstream Events (R-HSA-181431) -9.180.0CHRNA4, CHRNA2, CHRNB2
Highly sodium permeable acetylcholine nicotinic receptors (R-HSA-629587) -10.180.0CHRNA4, CHRNB2
Activation of Nicotinic Acetylcholine Receptors (R-HSA-629602) -9.180.0CHRNA4, CHRNA2, CHRNB2
Highly calcium permeable nicotinic acetylcholine receptors (R-HSA-629597) -9.810.0CHRNA4, CHRNA2, CHRNB2
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (R-HSA-629594) -9.520.0CHRNA4, CHRNA2, CHRNB2
Postsynaptic nicotinic acetylcholine receptors (R-HSA-622327) -9.180.0CHRNA4, CHRNA2, CHRNB2
Presynaptic nicotinic acetylcholine receptors (R-HSA-622323) -9.40.0CHRNA4, CHRNA2, CHRNB2
Neuronal System (R-HSA-112316) -4.820.0CHRNA4, CHRNA2, CHRNB2
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell (R-HSA-112314) -5.850.0CHRNA4, CHRNA2, CHRNB2
Transmission across Chemical Synapses (R-HSA-112315) -5.280.001CHRNA4, CHRNA2, CHRNB2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
substrate-specific transmembrane transporter activity (GO:0022891) 2.94CHRNA4, CHRNA2, KCNT1, CHRNB2
substrate-specific transporter activity (GO:0022892) 2.724CHRNA4, CHRNA2, KCNT1, CHRNB2
cation channel activity (GO:0005261) 4.044KCNT1, CHRNA2, CHRNA4, CHRNB2
transporter activity (GO:0005215) 2.574CHRNA4, CHRNA2, KCNT1, CHRNB2
ion channel activity (GO:0005216) 3.714CHRNA4, CHRNA2, KCNT1, CHRNB2
cation transmembrane transporter activity (GO:0008324) 3.324CHRNA4, CHRNA2, KCNT1, CHRNB2
ion transmembrane transporter activity (GO:0015075) 3.044CHRNA4, CHRNA2, KCNT1, CHRNB2
transmembrane transporter activity (GO:0022857) 2.824KCNT1, CHRNA2, CHRNA4, CHRNB2
channel activity (GO:0015267) 3.64CHRNA4, CHRNA2, KCNT1, CHRNB2
binding (GO:0005488) 0.184CHRNA4, SPAG1, CHRNA2, CHRNB2
passive transmembrane transporter activity (GO:0022803) 3.64KCNT1, CHRNA2, CHRNA4, CHRNB2
substrate-specific channel activity (GO:0022838) 3.674KCNT1, CHRNA2, CHRNA4, CHRNB2
gated channel activity (GO:0022836) 3.964CHRNA4, CHRNA2, KCNT1, CHRNB2
cation binding (GO:0043169) 1.43CHRNA4, CHRNA2, CHRNB2
neurotransmitter receptor activity (GO:0030594) 5.53CHRNA4, CHRNA2, CHRNB2
signaling receptor activity (GO:0038023) 2.493CHRNA4, CHRNA2, CHRNB2
acetylcholine binding (GO:0042166) 6.563CHRNA4, CHRNA2, CHRNB2
extracellular ligand-gated ion channel activity (GO:0005230) 5.423CHRNA4, CHRNA2, CHRNB2
excitatory extracellular ligand-gated ion channel activity (GO:0005231) 5.733CHRNA4, CHRNA2, CHRNB2
ligand-gated ion channel activity (GO:0015276) 4.83CHRNA4, CHRNA2, CHRNB2
neurotransmitter binding (GO:0042165) 6.343CHRNA4, CHRNA2, CHRNB2
ion binding (GO:0043167) 1.363CHRNA4, CHRNA2, CHRNB2
ammonium ion binding (GO:0070405) 5.813CHRNA4, CHRNA2, CHRNB2
molecular transducer activity (GO:0060089) 2.323CHRNA4, CHRNA2, CHRNB2
transmembrane signaling receptor activity (GO:0004888) 2.573CHRNA4, CHRNA2, CHRNB2
acetylcholine-activated cation-selective channel activity (GO:0004889) 6.653CHRNA4, CHRNA2, CHRNB2
acetylcholine receptor activity (GO:0015464) 6.33CHRNA4, CHRNA2, CHRNB2
signal transducer activity (GO:0004871) 2.283CHRNA4, CHRNA2, CHRNB2
ligand-gated channel activity (GO:0022834) 4.83CHRNA4, CHRNA2, CHRNB2
transmembrane receptor activity (GO:0099600) 2.533CHRNA4, CHRNA2, CHRNB2
receptor activity (GO:0004872) 2.323CHRNA4, CHRNA2, CHRNB2
drug binding (GO:0008144) 5.032CHRNA2, CHRNB2

NET-GE enrichment

Term New enriched termICP valueGenes
cation channel activity (GO:0005261) -4.040.001CHRNA4, CHRNA2, KCNT1, CHRNB2
acetylcholine receptor activity (GO:0015464) -6.30.0CHRNA4, CHRNA2, CHRNB2
drug binding (GO:0008144) -5.030.003CHRNA4, CHRNA2, CHRNB2
ligand-gated ion channel activity (GO:0015276) -4.80.005CHRNA4, CHRNA2, CHRNB2
acetylcholine-activated cation-selective channel activity (GO:0004889) -6.650.0CHRNA4, CHRNA2, CHRNB2
passive transmembrane transporter activity (GO:0022803) -3.60.003KCNT1, CHRNA2, CHRNA4, CHRNB2
ion channel activity (GO:0005216) -3.710.0CHRNA4, CHRNA2, KCNT1, CHRNB2
neurotransmitter receptor activity (GO:0030594) -5.50.0CHRNA4, CHRNA2, CHRNB2
transporter activity (GO:0005215) -2.570.009KCNT1, CHRNA2, CHRNA4, CHRNB2
extracellular ligand-gated ion channel activity (GO:0005230) -5.420.0CHRNA4, CHRNA2, CHRNB2
excitatory extracellular ligand-gated ion channel activity (GO:0005231) -5.730.0CHRNA4, CHRNA2, CHRNB2
acetylcholine binding (GO:0042166) -6.560.0CHRNA4, CHRNA2, CHRNB2
neurotransmitter binding (GO:0042165) -6.340.0CHRNA4, CHRNA2, CHRNB2
cation transmembrane transporter activity (GO:0008324) -3.320.001KCNT1, CHRNA2, CHRNA4, CHRNB2
substrate-specific transmembrane transporter activity (GO:0022891) -2.90.002CHRNA4, CHRNA2, KCNT1, CHRNB2
substrate-specific transporter activity (GO:0022892) -2.720.004CHRNA4, CHRNA2, KCNT1, CHRNB2
ion transmembrane transporter activity (GO:0015075) -3.040.002CHRNA4, CHRNA2, KCNT1, CHRNB2
transmembrane transporter activity (GO:0022857) -2.820.003KCNT1, CHRNA2, CHRNA4, CHRNB2
channel activity (GO:0015267) -3.60.003KCNT1, CHRNA2, CHRNA4, CHRNB2
gated channel activity (GO:0022836) -3.960.0CHRNA4, CHRNA2, KCNT1, CHRNB2
ligand-gated channel activity (GO:0022834) -4.80.005CHRNA4, CHRNA2, CHRNB2
substrate-specific channel activity (GO:0022838) -3.670.003KCNT1, CHRNA2, CHRNA4, CHRNB2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.265SPAG1, KCNT1, CHRNA2, CHRNA4, CHRNB2
single-organism cellular process (GO:0044763) 0.655SPAG1, CHRNA4, CHRNA2, KCNT1, CHRNB2
single-organism process (GO:0044699) 0.485SPAG1, CHRNA4, CHRNA2, KCNT1, CHRNB2
cation transmembrane transport (GO:0098655) 3.434KCNT1, CHRNA2, CHRNA4, CHRNB2
cation transport (GO:0006812) 3.114KCNT1, CHRNA2, CHRNA4, CHRNB2
ion transport (GO:0006811) 2.664CHRNA4, CHRNA2, KCNT1, CHRNB2
transport (GO:0006810) 1.514CHRNA4, CHRNA2, KCNT1, CHRNB2
localization (GO:0051179) 1.44KCNT1, CHRNA2, CHRNA4, CHRNB2
ion transmembrane transport (GO:0034220) 3.084KCNT1, CHRNA2, CHRNA4, CHRNB2
establishment of localization (GO:0051234) 1.484CHRNA4, CHRNA2, KCNT1, CHRNB2
transmembrane transport (GO:0055085) 2.724KCNT1, CHRNA2, CHRNA4, CHRNB2
cellular component assembly (GO:0022607) 2.143CHRNA2, SPAG1, CHRNB2
macromolecular complex subunit organization (GO:0043933) 2.143CHRNA2, SPAG1, CHRNB2
response to stimulus (GO:0050896) 1.223CHRNA4, CHRNA2, CHRNB2
signaling (GO:0023052) 3.253CHRNA4, CHRNA2, CHRNB2
signal transduction (GO:0007165) 1.283CHRNA4, CHRNA2, CHRNB2
response to chemical (GO:0042221) 1.983CHRNA4, CHRNA2, CHRNB2
synaptic transmission, cholinergic (GO:0007271) 6.23CHRNA4, CHRNA2, CHRNB2
neuromuscular synaptic transmission (GO:0007274) 6.433CHRNA4, CHRNA2, CHRNB2
regulation of biological process (GO:0050789) 0.453CHRNA4, CHRNA2, CHRNB2
response to organic cyclic compound (GO:0014070) 3.073CHRNA4, CHRNA2, CHRNB2
response to endogenous stimulus (GO:0009719) 2.793CHRNA4, CHRNA2, CHRNB2
protein complex subunit organization (GO:0071822) 2.63CHRNA2, SPAG1, CHRNB2
cellular component organization (GO:0016043) 1.243CHRNA2, SPAG1, CHRNB2
macromolecular complex assembly (GO:0065003) 2.553CHRNA2, SPAG1, CHRNB2
biological regulation (GO:0065007) 0.393CHRNA4, CHRNA2, CHRNB2
cellular component organization or biogenesis (GO:0071840) 1.223CHRNA2, SPAG1, CHRNB2
protein complex assembly (GO:0006461) 2.783CHRNA2, SPAG1, CHRNB2
regulation of cellular process (GO:0050794) 0.53CHRNA4, CHRNA2, CHRNB2
metal ion transport (GO:0030001) 3.363KCNT1, CHRNA4, CHRNB2
chemical synaptic transmission (GO:0007268) 3.983CHRNA4, CHRNA2, CHRNB2
cell-cell signaling (GO:0007267) 3.353CHRNA4, CHRNA2, CHRNB2
response to alkaloid (GO:0043279) 4.833CHRNA4, CHRNA2, CHRNB2
response to organic substance (GO:0010033) 2.23CHRNA4, CHRNA2, CHRNB2
single organism signaling (GO:0044700) 3.253CHRNA4, CHRNA2, CHRNB2
response to nitrogen compound (GO:1901698) 3.123CHRNA4, CHRNA2, CHRNB2
response to nicotine (GO:0035094) 5.783CHRNA4, CHRNA2, CHRNB2
cell communication (GO:0007154) 3.043CHRNA4, CHRNA2, CHRNB2
anterograde trans-synaptic signaling (GO:0098916) 3.983CHRNA4, CHRNA2, CHRNB2
response to organonitrogen compound (GO:0010243) 3.23CHRNA4, CHRNA2, CHRNB2
synaptic signaling (GO:0099536) 3.983CHRNA4, CHRNA2, CHRNB2
trans-synaptic signaling (GO:0099537) 3.983CHRNA4, CHRNA2, CHRNB2
regulation of membrane potential (GO:0042391) 3.892CHRNA4, CHRNB2
regulation of secretion (GO:0051046) 3.22CHRNA4, CHRNB2
regulation of transport (GO:0051049) 2.242CHRNA4, CHRNB2
B cell activation (GO:0042113) 4.842CHRNA4, CHRNB2
behavior (GO:0007610) 3.472CHRNA4, CHRNB2
leukocyte activation (GO:0045321) 3.762CHRNA4, CHRNB2
membrane depolarization (GO:0051899) 5.622CHRNA4, CHRNB2
regulation of secretion by cell (GO:1903530) 3.282CHRNA4, CHRNB2
cell surface receptor signaling pathway (GO:0007166) 2.092CHRNA2, CHRNB2
action potential (GO:0001508) 5.422CHRNA4, CHRNB2
regulation of dopamine secretion (GO:0014059) 6.642CHRNA4, CHRNB2
response to hypoxia (GO:0001666) 4.132CHRNA4, CHRNB2
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.792CHRNA2, CHRNB2
response to oxygen levels (GO:0070482) 4.022CHRNA4, CHRNB2
regulation of catecholamine secretion (GO:0050433) 5.992CHRNA4, CHRNB2
behavioral response to nicotine (GO:0035095) 7.782CHRNA4, CHRNB2
sensory perception of pain (GO:0019233) 5.622CHRNA4, CHRNB2
regulation of biological quality (GO:0065008) 1.682CHRNA4, CHRNB2
developmental process (GO:0032502) 1.362SPAG1, CHRNB2
locomotory behavior (GO:0007626) 4.532CHRNA4, CHRNB2
multicellular organismal process (GO:0032501) 1.452CHRNA4, CHRNB2
chemical synaptic transmission, postsynaptic (GO:0099565) 6.262CHRNA2, CHRNB2
adult behavior (GO:0030534) 4.792CHRNA4, CHRNB2
neurological system process (GO:0050877) 2.642CHRNA4, CHRNB2
protein heterooligomerization (GO:0051291) 5.222CHRNA2, CHRNB2
sensory perception (GO:0007600) 2.932CHRNA4, CHRNB2
calcium ion transport (GO:0006816) 4.332CHRNA4, CHRNB2
single-organism developmental process (GO:0044767) 1.492SPAG1, CHRNB2
regulation of amine transport (GO:0051952) 5.622CHRNA4, CHRNB2
response to stress (GO:0006950) 1.82CHRNA4, CHRNB2
lymphocyte activation (GO:0046649) 3.962CHRNA4, CHRNB2
divalent metal ion transport (GO:0070838) 4.152CHRNA4, CHRNB2
regulation of localization (GO:0032879) 1.942CHRNA4, CHRNB2
system process (GO:0003008) 2.32CHRNA4, CHRNB2
protein oligomerization (GO:0051259) 3.712CHRNA2, CHRNB2
response to abiotic stimulus (GO:0009628) 2.82CHRNA4, CHRNB2
divalent inorganic cation transport (GO:0072511) 4.132CHRNA4, CHRNB2
single-multicellular organism process (GO:0044707) 1.782CHRNA4, CHRNB2
single-organism behavior (GO:0044708) 3.792CHRNA4, CHRNB2
cognition (GO:0050890) 4.22CHRNA4, CHRNB2
cell activation (GO:0001775) 3.472CHRNA4, CHRNB2
immune system process (GO:0002376) 2.292CHRNA4, CHRNB2
response to decreased oxygen levels (GO:0036293) 4.092CHRNA4, CHRNB2

NET-GE enrichment

Term New enriched termICP valueGenes
synaptic transmission, cholinergic (GO:0007271) -6.20.002CHRNA4, CHRNB2
action potential (GO:0001508) -5.420.032CHRNA4, CHRNB2
regulation of dopamine secretion (GO:0014059) -6.640.018CHRNA4, CHRNB2
neuromuscular synaptic transmission (GO:0007274) -6.430.023CHRNA4, CHRNB2
regulation of catecholamine secretion (GO:0050433) -5.990.009CHRNA4, CHRNB2
regulation of circadian sleep/wake cycle (GO:0042749) NEW6.510.008CHRNA4, CHRNB2
circadian behavior (GO:0048512) NEW6.840.042CHRNA4, CHRNB2
regulation of action potential (GO:0098900) NEW6.070.012CHRNA4, CHRNB2
sensory perception of pain (GO:0019233) -5.620.017CHRNA4, CHRNB2
central nervous system projection neuron axonogenesis (GO:0021952) NEW6.730.03CHRNA4, CHRNB2
cation transport (GO:0006812) -3.110.005CHRNA4, CHRNA2, KCNT1, CHRNB2
ion transport (GO:0006811) -2.660.027KCNT1, CHRNA2, CHRNA4, CHRNB2
protein heterooligomerization (GO:0051291) -5.220.047CHRNA2, CHRNB2
ion transmembrane transport (GO:0034220) -3.080.004KCNT1, CHRNA2, CHRNA4, CHRNB2
regulation of circadian sleep/wake cycle, sleep (GO:0045187) NEW6.590.008CHRNA4, CHRNB2
circadian sleep/wake cycle process (GO:0022410) NEW8.340.015CHRNA4, CHRNB2
synaptic transmission (GO:0007268) -3.980.03CHRNA4, CHRNA2, CHRNB2
transmembrane transport (GO:0055085) -2.720.021CHRNA4, CHRNA2, KCNT1, CHRNB2
behavioral response to nicotine (GO:0035095) -7.780.001CHRNA4, CHRNB2
response to nicotine (GO:0035094) -5.780.01CHRNA4, CHRNB2
regulation of amine transport (GO:0051952) -5.620.025CHRNA4, CHRNB2
cation transmembrane transport (GO:0098655) -3.430.001CHRNA4, CHRNA2, KCNT1, CHRNB2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.115SPAG1, KCNT1, CHRNA2, CHRNA4, CHRNB2
protein complex (GO:0043234) 1.514CHRNA4, CHRNA2, KCNT1, CHRNB2
transmembrane transporter complex (GO:1902495) 4.064CHRNA4, CHRNA2, KCNT1, CHRNB2
integral component of membrane (GO:0016021) 1.144CHRNA4, CHRNA2, KCNT1, CHRNB2
membrane (GO:0016020) 0.684KCNT1, CHRNA2, CHRNA4, CHRNB2
transporter complex (GO:1990351) 4.044KCNT1, CHRNA2, CHRNA4, CHRNB2
plasma membrane protein complex (GO:0098797) 3.554KCNT1, CHRNA2, CHRNA4, CHRNB2
membrane protein complex (GO:0098796) 2.844KCNT1, CHRNA2, CHRNA4, CHRNB2
ion channel complex (GO:0034702) 4.184CHRNA4, CHRNA2, KCNT1, CHRNB2
membrane part (GO:0044425) 0.954CHRNA4, CHRNA2, KCNT1, CHRNB2
plasma membrane (GO:0005886) 1.394KCNT1, CHRNA2, CHRNA4, CHRNB2
macromolecular complex (GO:0032991) 1.354CHRNA4, CHRNA2, KCNT1, CHRNB2
plasma membrane part (GO:0044459) 1.954KCNT1, CHRNA2, CHRNA4, CHRNB2
intrinsic component of membrane (GO:0031224) 1.134KCNT1, CHRNA2, CHRNA4, CHRNB2
synaptic membrane (GO:0097060) 4.223CHRNA4, CHRNA2, CHRNB2
plasma membrane region (GO:0098590) 2.973CHRNA4, CHRNA2, CHRNB2
receptor complex (GO:0043235) 4.013CHRNA4, CHRNA2, CHRNB2
plasma membrane receptor complex (GO:0098802) 4.633CHRNA4, CHRNA2, CHRNB2
acetylcholine-gated channel complex (GO:0005892) 6.673CHRNA4, CHRNA2, CHRNB2
postsynaptic membrane (GO:0045211) 4.473CHRNA4, CHRNA2, CHRNB2
synapse part (GO:0044456) 3.423CHRNA4, CHRNA2, CHRNB2
synapse (GO:0045202) 3.583CHRNA4, CHRNA2, CHRNB2
cell junction (GO:0030054) 2.753CHRNA4, CHRNA2, CHRNB2
external side of plasma membrane (GO:0009897) 4.462CHRNA4, CHRNB2
side of membrane (GO:0098552) 4.222CHRNA4, CHRNB2

NET-GE enrichment

Term New enriched termICP valueGenes
synaptic membrane (GO:0097060) -4.220.033CHRNA4, CHRNA2, CHRNB2
external side of plasma membrane (GO:0009897) -4.460.04CHRNA4, CHRNB2
transmembrane transporter complex (GO:1902495) -4.060.0CHRNA4, CHRNA2, KCNT1, CHRNB2
receptor complex (GO:0043235) -4.010.001CHRNA4, CHRNA2, CHRNB2
transporter complex (GO:1990351) -4.040.0CHRNA4, CHRNA2, KCNT1, CHRNB2
acetylcholine-gated channel complex (GO:0005892) -6.670.0CHRNA4, CHRNA2, CHRNB2
postsynaptic membrane (GO:0045211) -4.470.0CHRNA4, CHRNA2, CHRNB2
synapse part (GO:0044456) -3.420.004CHRNA4, CHRNA2, CHRNB2
ion channel complex (GO:0034702) -4.180.0KCNT1, CHRNA2, CHRNA4, CHRNB2
plasma membrane part (GO:0044459) -1.950.036KCNT1, CHRNA2, CHRNA4, CHRNB2