Disease table of LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER OMIM ID: 603896

Gene-disease associations table

GeneAssociated with LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
EIF2B4ClinVar, OMIM, HUMSAVARHGNC link2p23.31603896
EIF2B5ClinVar, OMIM, HUMSAVARHGNC link3q27.11603896
EIF2B2ClinVar, OMIM, HUMSAVARHGNC link14q24.31603896
EIF2B3ClinVar, OMIM, HUMSAVARHGNC link1p34.11603896
EIF2B1ClinVar, OMIM, HUMSAVARHGNC link12q24.311603896

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
EIF2B4EIF2B5Yes17EFNB2, VTI1B, EIF2B2, OPN3, EGFR, CA14, STX12, XPO1, EIF2B1, EIF2B3, IGSF8, NTRK1, P2RX4, GPR183, SPN, PTGER3, PNKD
EIF2B4EIF2B2Yes22EFNB2, EGFR, XPO1, IGSF8, GPR183, RPL10, EIF2B1, CA14, DCC, PNKD, PVRL4, SPN, VTI1B, EIF2B5, SRP72, P2RX4, STX12, OPN3, HNRNPU, EIF2B3, PTGER3, EPB41L3
EIF2B4EIF2B3Yes17SCN2B, PVRL4, EIF2B2, PTGER3, CA14, STX12, EIF2B1, XPO1, P2RX4, HNRNPU, OPN3, EGFR, VTI1B, GPR183, SPN, EIF2B5, PNKD
EIF2B4EIF2B1Yes19EIF2S1, PVRL4, EGFR, PTGER3, CA14, STX12, EIF2B1, XPO1, P2RX4, DCC, HNRNPU, NOP56, RPL10, EIF2B2, NTRK1, VTI1B, EIF2B5, GPR183, EIF2B3
EIF2B5EIF2B2Yes18EIF2B3, EFNB2, EIF3K, CA14, PTGER3, EGFR, STX12, XPO1, P2RX4, EIF2B1, APP, IGSF8, OPN3, VTI1B, EIF2B4, SPN, GPR183, PNKD
EIF2B5EIF2B3Yes14VTI1B, EGFR, PTGER3, STX12, XPO1, EIF2B1, OPN3, CA14, P2RX4, EIF2B4, SPN, GPR183, PNKD, EIF2B2
EIF2B5EIF2B1Yes13VTI1B, EGFR, PTGER3, STX12, XPO1, EIF2B1, CA14, NTRK1, P2RX4, EIF2B4, GPR183, EIF2B3, EIF2B2
EIF2B2EIF2B3Yes33YBX3, NMT1, RTCB, STX12, XPO1, IGF2BP3, EGFR, GPR183, EIF2B5, DIMT1, HNRNPM, EIF2B1, DHX9, CA14, DDX1, PNKD, PVRL4, ABCF1, EDC4, MRE11A, QARS, C14ORF166, SPN, VTI1B, EIF2B4, NELFB, P2RX4, FKBP3, OPN3, HNRNPU, ILF2, RFC4, PTGER3
EIF2B2EIF2B1Yes16EIF2B5, CA14, VTI1B, STX12, EIF2B1, XPO1, P2RX4, HNRNPU, RPL10, EGFR, PTGER3, DCC, PVRL4, EIF2B4, GPR183, EIF2B3
EIF2B3EIF2B1Yes15EIF2B5, EIF2B2, VTI1B, CA14, STX12, EIF2B1, XPO1, P2RX4, HNRNPU, PVRL4, EGFR, PTGER3, HNRNPA1, EIF2B4, GPR183

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
EIF2B4EIF2B5Yesbinding11HSDL1, EIF2S1, HSD17B12, IST1, EIF2S3, HSD17B3, EIF2B1, EIF2S2, EIF2B2, UBC, EIF2B3
EIF2B4EIF2B2Yesbinding14HSDL1, EIF2S1, IST1, EIF2B1, JUND, HSD17B3, JUN, EIF2S2, HSD17B12, EIF2S3, UBC, JUNB, EIF2B5, EIF2B3
EIF2B4EIF2B3Yesbinding9EIF2S3, HSD17B12, IST1, EIF2S1, EIF2B1, EIF2B2, UBC, EIF2B5, EIF2S2
EIF2B4EIF2B1Yesbinding14HSDL1, EIF2S1, EIF2B5, EIF2B2, IST1, EIF2S3, HSD17B3, JUN, EIF2S2, HSD17B12, UBC, JUNB, JUND, EIF2B3
EIF2B5EIF2B2Yesbinding11HSDL1, EIF2S1, IST1, EIF2S3, HSD17B3, EIF2B1, EIF2S2, HSD17B12, UBC, EIF2B4, EIF2B3
EIF2B5EIF2B3Yesbinding9EIF2S3, HSD17B12, IST1, EIF2S1, EIF2B1, EIF2B2, UBC, EIF2B4, EIF2S2
EIF2B5EIF2B1Yesbinding11HSDL1, EIF2S1, HSD17B12, IST1, EIF2S3, HSD17B3, EIF2S2, EIF2B2, UBC, EIF2B4, EIF2B3
EIF2B2EIF2B3Yesbinding9EIF2S3, IST1, EIF2S1, EIF2B1, HSD17B12, UBC, EIF2B4, EIF2B5, EIF2S2
EIF2B2EIF2B1Yesbinding19EIF2B4, HSDL1, EIF2S1, KPNA3, IST1, EIF2S2, KPNA4, EIF2S3, JUND, KPNA2, DGCR14, JUN, KPNA7, HSD17B12, HSD17B3, UBC, JUNB, EIF2B5, EIF2B3
EIF2B3EIF2B1Yesbinding9EIF2S3, EIF2B2, IST1, EIF2S1, HSD17B12, UBC, EIF2B4, EIF2B5, EIF2S2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
EIF2B4EIF2B5Yes2EIF2B3, EIF2B2
EIF2B4EIF2B2Yes2EIF2B5, EIF2B3
EIF2B4EIF2B3Yes2EIF2B5, EIF2B2
EIF2B5EIF2B2Yes2EIF2B4, EIF2B3
EIF2B5EIF2B3Yes2EIF2B4, EIF2B2
EIF2B2EIF2B3Yes2EIF2B4, EIF2B5

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
RNA transporthsa030135.375EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1

NET-GE enrichment

Term New enriched termICP valueGenes
Genetic Information ProcessingNEW2.480.026EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
RNA transport (hsa03013) -5.370.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
TranslationNEW3.910.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Gene ExpressionR-HSA-741602.725EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Metabolism of proteinsR-HSA-3924993.415EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
TranslationR-HSA-727665.85EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Recycling of eIF2:GDPR-HSA-727319.985EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Cap-dependent Translation InitiationR-HSA-727376.185EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Eukaryotic Translation InitiationR-HSA-726136.185EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1

NET-GE enrichment

Term New enriched termICP valueGenes
Gene Expression (R-HSA-74160) -2.720.029EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Metabolism of proteins (R-HSA-392499) -3.410.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Translation (R-HSA-72766) -5.80.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Recycling of eIF2:GDP (R-HSA-72731) -9.980.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Cap-dependent Translation Initiation (R-HSA-72737) -6.180.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
Eukaryotic Translation Initiation (R-HSA-72613) -6.180.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
translation initiation factor activity (GO:0003743) 5.75EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
protein binding (GO:0005515) 0.465EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
organic cyclic compound binding (GO:0097159) 1.055EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
translation factor activity, RNA binding (GO:0008135) 5.075EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
guanyl-nucleotide exchange factor activity (GO:0005085) 4.025EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
binding (GO:0005488) 0.185EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
nucleic acid binding (GO:0003676) 1.445EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
molecular function regulator (GO:0098772) 2.515EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
heterocyclic compound binding (GO:1901363) 1.065EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
RNA binding (GO:0003723) 2.365EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
catalytic activity (GO:0003824) 1.054EIF2B4, EIF2B3, EIF2B2, EIF2B1
S-methyl-5-thioribose-1-phosphate isomerase activity (GO:0046523) 8.353EIF2B4, EIF2B1, EIF2B2
isomerase activity (GO:0016853) 4.623EIF2B4, EIF2B1, EIF2B2
intramolecular oxidoreductase activity, interconverting aldoses and ketoses (GO:0016861) 7.253EIF2B4, EIF2B1, EIF2B2
intramolecular oxidoreductase activity (GO:0016860) 5.753EIF2B4, EIF2B1, EIF2B2
translation initiation factor binding (GO:0031369) 6.372EIF2B4, EIF2B5

NET-GE enrichment

Term New enriched termICP valueGenes
oxidoreductase activity (GO:0016491) NEW3.120.049EIF2B5, EIF2B3, EIF2B2, EIF2B1
translation initiation factor binding (GO:0031369) -6.370.004EIF2B4, EIF2B5
translation factor activity, nucleic acid binding (GO:0008135) -5.070.01EIF2B4, EIF2B5, EIF2B3
RNA binding (GO:0003723) -2.360.013EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
translation initiation factor activity (GO:0003743) -5.70.004EIF2B4, EIF2B5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to hexose (GO:0009746) 4.825EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to abiotic stimulus (GO:0009628) 2.85EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of primary metabolic process (GO:0080090) 1.085EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of metabolic process (GO:0019222) 1.025EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of protein metabolic process (GO:0051246) 1.935EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cell development (GO:0048468) 3.285EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular biosynthetic process (GO:0044249) 1.375EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular nitrogen compound metabolic process (GO:0034641) 1.225EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
nitrogen compound metabolic process (GO:0006807) 1.135EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular macromolecule biosynthetic process (GO:0034645) 1.665EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to chemical (GO:0042221) 1.985EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to glucose (GO:0009749) 4.865EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of GTPase activity (GO:0043087) 3.215EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of biological process (GO:0050789) 0.455EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
single-organism process (GO:0044699) 0.485EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to endogenous stimulus (GO:0009719) 2.795EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
organic substance biosynthetic process (GO:1901576) 1.345EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular response to stimulus (GO:0051716) 1.975EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
glial cell development (GO:0021782) 5.785EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
positive regulation of hydrolase activity (GO:0051345) 2.915EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular developmental process (GO:0048869) 1.825EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of cellular metabolic process (GO:0031323) 1.075EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to nitrogen compound (GO:1901698) 3.125EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
peptide biosynthetic process (GO:0043043) 3.735EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
organic substance metabolic process (GO:0071704) 0.635EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
biological regulation (GO:0065007) 0.395EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
positive regulation of catalytic activity (GO:0043085) 2.45EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
positive regulation of molecular function (GO:0044093) 2.235EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of cellular biosynthetic process (GO:0031326) 1.385EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular protein metabolic process (GO:0044267) 1.635EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of molecular function (GO:0065009) 1.785EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of gene expression (GO:0010468) 1.375EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
developmental process (GO:0032502) 1.365EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of hydrolase activity (GO:0051336) 2.535EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular process (GO:0009987) 0.265EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
amide biosynthetic process (GO:0043604) 3.65EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of macromolecule metabolic process (GO:0060255) 1.085EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of translational initiation (GO:0006446) 5.325EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of catalytic activity (GO:0050790) 1.975EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of biosynthetic process (GO:0009889) 1.375EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular macromolecule metabolic process (GO:0044260) 0.935EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
single-organism developmental process (GO:0044767) 1.495EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to stress (GO:0006950) 1.85EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
macromolecule biosynthetic process (GO:0009059) 1.615EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
single-organism cellular process (GO:0044763) 0.655EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of nitrogen compound metabolic process (GO:0051171) 1.365EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
metabolic process (GO:0008152) 0.585EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to temperature stimulus (GO:0009266) 4.715EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
oligodendrocyte development (GO:0014003) 6.515EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to heat (GO:0009408) 5.245EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to peptide hormone (GO:0043434) 4.065EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of cellular process (GO:0050794) 0.55EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to organic substance (GO:0010033) 2.25EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
positive regulation of GTPase activity (GO:0043547) 3.285EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to oxygen-containing compound (GO:1901700) 2.575EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
primary metabolic process (GO:0044238) 0.695EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of cellular protein metabolic process (GO:0032268) 1.995EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
organonitrogen compound metabolic process (GO:1901564) 2.325EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
organonitrogen compound biosynthetic process (GO:1901566) 2.855EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular amide metabolic process (GO:0043603) 3.235EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to monosaccharide (GO:0034284) 4.775EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
protein metabolic process (GO:0019538) 1.455EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to hormone (GO:0009725) 3.335EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to organonitrogen compound (GO:0010243) 3.25EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
anatomical structure development (GO:0048856) 1.585EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
biosynthetic process (GO:0009058) 1.325EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular metabolic process (GO:0044237) 0.695EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
macromolecule metabolic process (GO:0043170) 0.835EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to carbohydrate (GO:0009743) 4.625EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
translation (GO:0006412) 3.795EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of macromolecule biosynthetic process (GO:0010556) 1.435EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to peptide (GO:1901652) 3.945EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
posttranscriptional regulation of gene expression (GO:0010608) 3.645EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of translation (GO:0006417) 3.965EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
peptide metabolic process (GO:0006518) 3.445EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of cellular amide metabolic process (GO:0034248) 3.885EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
translational initiation (GO:0006413) 4.725EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to stimulus (GO:0050896) 1.225EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of metabolic process (GO:0009892) 1.933EIF2B4, EIF2B5, EIF2B3
ovulation cycle process (GO:0022602) 5.253EIF2B4, EIF2B5, EIF2B2
negative regulation of cellular biosynthetic process (GO:0031327) 2.493EIF2B4, EIF2B5, EIF2B3
negative regulation of cellular metabolic process (GO:0031324) 2.013EIF2B4, EIF2B5, EIF2B3
L-methionine salvage (GO:0071267) 7.433EIF2B4, EIF2B1, EIF2B2
carboxylic acid metabolic process (GO:0019752) 3.123EIF2B4, EIF2B1, EIF2B2
L-methionine biosynthetic process (GO:0071265) 7.433EIF2B4, EIF2B1, EIF2B2
negative regulation of gene expression (GO:0010629) 2.483EIF2B4, EIF2B5, EIF2B3
aspartate family amino acid biosynthetic process (GO:0009067) 6.593EIF2B4, EIF2B1, EIF2B2
aspartate family amino acid metabolic process (GO:0009066) 5.723EIF2B4, EIF2B1, EIF2B2
small molecule biosynthetic process (GO:0044283) 3.793EIF2B4, EIF2B1, EIF2B2
ensheathment of neurons (GO:0007272) 5.483EIF2B4, EIF2B5, EIF2B2
single-organism metabolic process (GO:0044710) 1.633EIF2B4, EIF2B1, EIF2B2
single-organism biosynthetic process (GO:0044711) 2.83EIF2B4, EIF2B1, EIF2B2
L-methionine biosynthetic process from methylthioadenosine (GO:0019509) 7.653EIF2B4, EIF2B1, EIF2B2
ovarian follicle development (GO:0001541) 5.823EIF2B4, EIF2B5, EIF2B2
cellular amino acid metabolic process (GO:0006520) 4.223EIF2B4, EIF2B1, EIF2B2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63EIF2B4, EIF2B5, EIF2B3
rhythmic process (GO:0048511) 4.023EIF2B4, EIF2B5, EIF2B2
amino acid salvage (GO:0043102) 7.433EIF2B4, EIF2B1, EIF2B2
negative regulation of biological process (GO:0048519) 1.333EIF2B4, EIF2B5, EIF2B3
alpha-amino acid metabolic process (GO:1901605) 4.53EIF2B4, EIF2B1, EIF2B2
negative regulation of biosynthetic process (GO:0009890) 2.473EIF2B4, EIF2B5, EIF2B3
negative regulation of translational initiation in response to stress (GO:0032057) 7.783EIF2B4, EIF2B5, EIF2B3
reproductive structure development (GO:0048608) 4.083EIF2B4, EIF2B5, EIF2B2
negative regulation of translation in response to stress (GO:0032055) 7.533EIF2B4, EIF2B5, EIF2B3
negative regulation of translational initiation (GO:0045947) 6.643EIF2B4, EIF2B5, EIF2B3
negative regulation of protein metabolic process (GO:0051248) 2.823EIF2B4, EIF2B5, EIF2B3
negative regulation of cellular amide metabolic process (GO:0034249) 4.963EIF2B4, EIF2B5, EIF2B3
developmental process involved in reproduction (GO:0003006) 3.363EIF2B4, EIF2B5, EIF2B2
axon ensheathment (GO:0008366) 5.483EIF2B4, EIF2B5, EIF2B2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473EIF2B4, EIF2B5, EIF2B3
oxoacid metabolic process (GO:0043436) 3.123EIF2B4, EIF2B1, EIF2B2
myelination (GO:0042552) 5.523EIF2B4, EIF2B5, EIF2B2
cellular metabolic compound salvage (GO:0043094) 6.073EIF2B4, EIF2B1, EIF2B2
cellular amino acid biosynthetic process (GO:0008652) 5.493EIF2B4, EIF2B1, EIF2B2
negative regulation of cellular protein metabolic process (GO:0032269) 2.883EIF2B4, EIF2B5, EIF2B3
single organism reproductive process (GO:0044702) 2.733EIF2B4, EIF2B5, EIF2B2
regulation of translation in response to stress (GO:0043555) 6.783EIF2B4, EIF2B5, EIF2B3
organic acid metabolic process (GO:0006082) 3.013EIF2B4, EIF2B1, EIF2B2
reproductive process (GO:0022414) 2.553EIF2B4, EIF2B5, EIF2B2
carboxylic acid biosynthetic process (GO:0046394) 4.323EIF2B4, EIF2B1, EIF2B2
regulation of translational initiation in response to stress (GO:0043558) 7.163EIF2B4, EIF2B5, EIF2B3
methionine metabolic process (GO:0006555) 6.843EIF2B4, EIF2B1, EIF2B2
organic acid biosynthetic process (GO:0016053) 4.263EIF2B4, EIF2B1, EIF2B2
negative regulation of macromolecule metabolic process (GO:0010605) 2.013EIF2B4, EIF2B5, EIF2B3
alpha-amino acid biosynthetic process (GO:1901607) 5.513EIF2B4, EIF2B1, EIF2B2
cellular response to stress (GO:0033554) 2.513EIF2B4, EIF2B5, EIF2B3
negative regulation of translation (GO:0017148) 5.033EIF2B4, EIF2B5, EIF2B3
methionine biosynthetic process (GO:0009086) 7.093EIF2B4, EIF2B1, EIF2B2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533EIF2B4, EIF2B5, EIF2B3
negative regulation of cellular process (GO:0048523) 1.413EIF2B4, EIF2B5, EIF2B3
small molecule metabolic process (GO:0044281) 2.383EIF2B4, EIF2B1, EIF2B2

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of catabolic process (GO:0009894) NEW3.520.037EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of phosphate metabolic process (GO:0019220) NEW2.350.001EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular developmental process (GO:0048869) -1.820.004EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of cellular catabolic process (GO:0031329) NEW3.830.024EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of cellular biosynthetic process (GO:0031327) -2.490.009EIF2B4, EIF2B5, EIF2B3, EIF2B1
regulation of cellular macromolecule biosynthetic process (GO:2000112) -1.460.049EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of cellular metabolic process (GO:0031324) -2.010.038EIF2B4, EIF2B5, EIF2B3, EIF2B1
cell development (GO:0048468) -3.280.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular macromolecule biosynthetic process (GO:0034645) -1.660.015EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to chemical (GO:0042221) -1.980.022EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
ensheathment of neurons (GO:0007272) -5.480.006EIF2B4, EIF2B5, EIF2B2
regulation of cellular protein metabolic process (GO:0032268) -1.990.001EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of GTPase activity (GO:0043087) -3.210.001EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of hydrolase activity (GO:0051336) -2.530.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
ovulation cycle process (GO:0022602) -5.250.01EIF2B4, EIF2B5, EIF2B2
response to endogenous stimulus (GO:0009719) -2.790.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular protein metabolic process (GO:0044267) -1.630.018EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of protein metabolic process (GO:0051248) -2.820.001EIF2B4, EIF2B5, EIF2B3, EIF2B1
regulation of carbohydrate biosynthetic process (GO:0043255) NEW5.250.009EIF2B4, EIF2B1, EIF2B2
myelination (GO:0042552) -5.520.005EIF2B4, EIF2B5, EIF2B2
positive regulation of GTPase activity (GO:0043547) -3.280.001EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
positive regulation of hydrolase activity (GO:0051345) -2.910.021EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
posttranscriptional regulation of gene expression (GO:0010608) -3.640.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
mRNA metabolic process (GO:0016071) NEW3.330.033EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of protein metabolic process (GO:0051246) -1.930.002EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) -2.60.007EIF2B4, EIF2B5, EIF2B3, EIF2B1
regulation of nucleotide catabolic process (GO:0030811) NEW8.340.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
rhythmic process (GO:0048511) -4.020.003EIF2B4, EIF2B5, EIF2B2
gene expression (GO:0010467) NEW5.80.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of translation (GO:0017148) -5.030.0EIF2B4, EIF2B5, EIF2B3, EIF2B1
positive regulation of catalytic activity (GO:0043085) -2.40.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
positive regulation of molecular function (GO:0044093) -2.230.001EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of molecular function (GO:0065009) -1.780.007EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of biosynthetic process (GO:0009890) -2.470.01EIF2B4, EIF2B5, EIF2B3, EIF2B1
response to hexose (GO:0009746) -4.820.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of purine nucleotide catabolic process (GO:0033121) NEW8.340.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of translational initiation in response to stress (GO:0032057) -7.780.0EIF2B4, EIF2B5, EIF2B3, EIF2B1
reproductive structure development (GO:0048608) -4.080.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of macromolecule metabolic process (GO:0010605) -2.010.036EIF2B4, EIF2B5, EIF2B3, EIF2B1
negative regulation of translation in response to stress (GO:0032055) -7.530.0EIF2B4, EIF2B5, EIF2B3, EIF2B1
regulation of translational initiation (GO:0006446) -5.320.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of catalytic activity (GO:0050790) -1.970.003EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of phosphorus metabolic process (GO:0051174) NEW2.350.001EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
developmental process involved in reproduction (GO:0003006) -3.360.034EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to stress (GO:0006950) -1.80.011EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
macromolecule biosynthetic process (GO:0009059) -1.610.02EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
axon ensheathment (GO:0008366) -5.480.006EIF2B4, EIF2B5, EIF2B2
response to temperature stimulus (GO:0009266) -4.710.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
oligodendrocyte development (GO:0014003) -6.510.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to heat (GO:0009408) -5.240.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to peptide hormone (GO:0043434) -4.060.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of nucleoside metabolic process (GO:0009118) NEW5.820.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to organic substance (GO:0010033) -2.20.004EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
ovarian follicle development (GO:0001541) -5.820.001EIF2B4, EIF2B5, EIF2B2
response to oxygen-containing compound (GO:1901700) -2.570.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to abiotic stimulus (GO:0009628) -2.80.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
negative regulation of cellular protein metabolic process (GO:0032269) -2.880.0EIF2B4, EIF2B5, EIF2B3, EIF2B1
regulation of purine nucleotide metabolic process (GO:1900542) NEW4.410.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of translation in response to stress (GO:0043555) -6.780.0EIF2B4, EIF2B5, EIF2B3, EIF2B1
response to carbohydrate (GO:0009743) -4.620.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to monosaccharide (GO:0034284) -4.770.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to hormone (GO:0009725) -3.330.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to nitrogen compound (GO:1901698) -3.120.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
anatomical structure development (GO:0048856) -1.580.008EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
glial cell development (GO:0021782) -5.780.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to glucose (GO:0009749) -4.860.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of translational initiation in response to stress (GO:0043558) -7.160.0EIF2B4, EIF2B5, EIF2B3, EIF2B1
negative regulation of macromolecule biosynthetic process (GO:0010558) -2.530.008EIF2B4, EIF2B5, EIF2B3, EIF2B1
response to peptide (GO:1901652) -3.940.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cellular response to stress (GO:0033554) -2.510.012EIF2B4, EIF2B5, EIF2B3, EIF2B1
negative regulation of translational initiation (GO:0045947) -6.640.0EIF2B4, EIF2B5, EIF2B3, EIF2B1
regulation of translation (GO:0006417) -3.960.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
regulation of nucleotide metabolic process (GO:0006140) NEW4.380.007EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
translation (GO:0006412) -3.790.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
translational initiation (GO:0006413) -4.720.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
response to organonitrogen compound (GO:0010243) -3.20.011EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.515EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cytoplasm (GO:0005737) 1.015EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
macromolecular complex (GO:0032991) 1.355EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
eukaryotic translation initiation factor 2B complex (GO:0005851) 8.015EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cytosol (GO:0005829) 1.685EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cell part (GO:0044464) 0.115EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cytoplasmic part (GO:0044444) 0.825EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
intracellular part (GO:0044424) 0.285EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1

NET-GE enrichment

Term New enriched termICP valueGenes
protein complex (GO:0043234) -1.510.007EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cytoplasm (GO:0005737) -1.010.014EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
cytosol (GO:0005829) -1.680.001EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
macromolecular complex (GO:0032991) -1.350.016EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1
eukaryotic translation initiation factor 2B complex (GO:0005851) -8.010.0EIF2B3, EIF2B4, EIF2B5, EIF2B2, EIF2B1