Disease table of MECKEL SYNDROME OMIM ID: PS249000

Gene-disease associations table

Gene	Associated with MECKEL SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TMEM67	ClinVar, OMIM, HUMSAVAR	HGNC link	8q22.1	5	PS249000, PS213300, PS256100, 216360, PS209900
KIF14	ClinVar, OMIM	HGNC link	1q32.1	1	PS249000
TCTN2	ClinVar, OMIM	HGNC link	12q24.31	2	PS213300, PS249000
MKS1	ClinVar, OMIM	HGNC link	17q22	3	PS213300, PS209900, PS249000
CEP290	ClinVar, OMIM	HGNC link	12q21.32	5	PS249000, PS213300, PS204000, 610189, PS209900
NPHP3	ClinVar, OMIM	HGNC link	3q22.1	3	PS249000, PS208540, PS256100
CC2D2A	ClinVar, OMIM, HUMSAVAR	HGNC link	4p15.32	3	PS213300, 216360, PS249000
TMEM216	ClinVar, OMIM, HUMSAVAR	HGNC link	11q12.2	2	PS213300, PS249000
RPGRIP1L	ClinVar, OMIM, HUMSAVAR	HGNC link	16q12.2	3	PS213300, 216360, PS249000
TMEM231	ClinVar, OMIM, HUMSAVAR	HGNC link	16q23.1	2	PS213300, PS249000
B9D2	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.2	1	PS249000
B9D1	ClinVar, OMIM	HGNC link	17p11.2	1	PS249000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12q2	2	CEP290, TCTN2

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
12q	2	CEP290, TCTN2
16q	2	RPGRIP1L, TMEM231

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	2	CEP290, TCTN2
17	2	MKS1, B9D1
16	2	RPGRIP1L, TMEM231

Transcription Factors (TF) annotation from TRRUST

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TMEM67	TCTN2	No	27	ATP6AP2, TMEM199, TOR1AIP1, CKAP4, SPCS3, EMC1, KIAA1715, HSPA5, BCAP31, PGRMC2, RPN1, MAGT1, VRK2, EMC2, UBXN4, STT3B, ATP6AP1, SPCS2, CCDC47, VMA21, PTPRK, SEC11A, PREB, CAMLG, HM13, SRPR, EMC3
TMEM67	CEP290	No	2	RAB2A, BCAP31
TMEM67	TMEM216	No	24	ATP6AP2, TMEM199, TOR1AIP1, CKAP4, SPCS3, EMC1, KIAA1715, BCAP31, PGRMC2, SLC6A8, EMC2, UBXN4, STT3B, ATP6AP1, SPCS2, CCDC47, VMA21, SEC11A, PREB, CAMLG, ATP6V0A1, SRPR, VRK2, EMC3
TMEM67	RPGRIP1L	No	5	PDCD11, DDX54, ERLIN2, SDHA, EMC3
KIF14	TCTN2	No	1	TMCO1
KIF14	CEP290	Yes	7	CEP128, CEP162, CEP104, PCM1, CCDC14, MED4, CEP135
KIF14	CC2D2A	No	1	PCM1
KIF14	TMEM216	No	1	EFNB2
KIF14	RPGRIP1L	Yes	8	CEP152, CEP128, CEP162, SPICE1, LCA5, NINL, CNTRL, PCM1
TCTN2	MKS1	Yes	2	B9D2, TMEM231
TCTN2	CEP290	No	3	BCAP31, DDX47, CYB5R3
TCTN2	CC2D2A	No	2	B9D2, MKS1
TCTN2	TMEM216	No	97	HMOX2, VEZT, KIAA1715, CISD2, VRK2, RHBDD2, DDRGK1, CCDC115, RABL3, SRPRB, SOAT1, TMX1, DNAJC1, AGPAT6, CERS2, VKORC1L1, JPH1, PREB, CAMLG, ALG9, SEC63, ATP6AP2, BET1, JAGN1, TRIM13, TMPO, GPR89A, PLD3, TEX264, SLC33A1, SEC22B, EMC2, CLCC1, UBXN4, VAPA, NCOA2, AUP1, LBR, MMGT1, ARL6IP5, CCDC47, LRRC59, SGPL1, CDKAL1, RAB7A, TMEM199, PTPN1, TOR1AIP1, FKBP8, VAPB, ACSL3, AGPAT1, WDR41, PGRMC2, DHRS7, NSDHL, EMC1, ATP6V1F, RER1, STT3B, ANO10, TMEM109, ALDH3A2, STIM1, UBE2J1, EMC8, STX5, SEC11A, EMD, LMAN1, VAMP2, NDC1, EMC7, YKT6, EMC3, OSBPL8, POR, CKAP4, SPCS3, LEMD3, TMEM209, VAMP3, PTPN2, BCAP31, SLC39A7, ITGB1, AGPAT9, ATP6AP1, ESYT1, ELAVL1, VMA21, VMP1, ANO6, TMEM214, SPCS2, ARHGAP1, SRPR
TCTN2	RPGRIP1L	No	4	PTPLB, SEC63, DDX47, EMC3
TCTN2	TMEM231	Yes	4	FBXO6, BTNL8, B9D2, MKS1
TCTN2	B9D2	Yes	3	TMEM231, MKS1, LEMD3
TCTN2	B9D1	No	3	TMEM231, MKS1, B9D2
MKS1	CEP290	No	6	TPGS1, LRRC49, HAUS7, FKBP4, HAUS8, ECH1
MKS1	CC2D2A	Yes	6	MB21D2, B9D1, HAUS8, B9D2, UNC45A, ECH1
MKS1	TMEM216	No	3	ARFGAP3, MB21D2, COPB1
MKS1	RPGRIP1L	No	5	DBT, HAUS8, SHMT2, TNRC6B, ECH1
MKS1	TMEM231	Yes	3	B9D1, B9D2, TCTN2
MKS1	B9D2	Yes	6	TCTN2, B9D1, TMEM231, YTHDF1, TNRC6B, CC2D2A
MKS1	B9D1	Yes	12	CCT7, PDCL3, CCT5, TMEM17, TMEM231, CCT3, CCT2, B9D2, TCP1, CCT4, CC2D2A, CCT6A
CEP290	CC2D2A	No	10	YWHAH, WDR83, CCDC138, HAUS8, GPATCH1, OFD1, PCM1, CEP131, SSX2IP, ECH1
CEP290	TMEM216	No	1	BCAP31
CEP290	RPGRIP1L	No	28	CSPP1, WDR83, HAUS8, GPATCH1, CCP110, HAUS3, DDX47, TCHP, CEP128, YWHAH, OFD1, PCNT, NME7, CEP97, SSX2IP, CEP170, CCDC138, LUZP1, CEP350, PCM1, KIF14, MPHOSPH9, HAUS6, KIAA0753, CHTOP, CEP131, CEP162, ECH1
CEP290	B9D2	No	1	ANP32A
NPHP3	RPGRIP1L	No	1	NPHP1
CC2D2A	TMEM216	No	1	MB21D2
CC2D2A	RPGRIP1L	No	11	YWHAH, WDR83, CCDC138, NHP2L1, GPATCH1, OFD1, ECH1, CEP131, HAUS8, SSX2IP, PCM1
CC2D2A	TMEM231	No	3	B9D1, B9D2, MKS1
CC2D2A	B9D2	Yes	3	TCTN3, B9D1, MKS1
CC2D2A	B9D1	Yes	2	B9D2, MKS1
TMEM216	RPGRIP1L	No	4	NUP155, SEC63, TFRC, EMC3
TMEM216	TMEM231	No	2	LSR, EPHA7
TMEM216	B9D2	No	1	LEMD3
RPGRIP1L	B9D2	No	7	KDM1A, IBTK, TJP1, EIF4ENIF1, TNRC6B, MOB4, ZNF318
TMEM231	B9D2	Yes	3	B9D1, MKS1, TCTN2
TMEM231	B9D1	Yes	2	B9D2, MKS1
B9D2	B9D1	Yes	4	TMEM231, MTR, CC2D2A, MKS1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TMEM67	TCTN2	Yes	binding	10	TMEM216, CEP290, MKS1, TMEM17, AHI1, TCTN1, TMEM231, B9D1, CC2D2A, B9D2
TMEM67	MKS1	Yes	binding	10	TMEM216, CEP290, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, B9D1, CC2D2A, B9D2
TMEM67	CEP290	Yes	binding	10	TMEM216, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, MKS1, B9D1, CC2D2A, B9D2
TMEM67	CC2D2A	Yes	binding	10	TMEM216, CEP290, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, MKS1, B9D1, B9D2
TMEM67	TMEM216	Yes	binding	10	CEP290, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, MKS1, B9D1, CC2D2A, B9D2
TMEM67	TMEM231	Yes	binding	10	TMEM216, CEP290, TMEM17, TCTN2, AHI1, TCTN1, MKS1, B9D1, CC2D2A, B9D2
TMEM67	B9D2	Yes	binding	10	TMEM216, CEP290, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, MKS1, B9D1, CC2D2A
TMEM67	B9D1	Yes	binding	10	TMEM216, CEP290, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, MKS1, CC2D2A, B9D2
KIF14	CEP290	No	-	1	UBC
TCTN2	MKS1	Yes	binding	10	TMEM216, CEP290, B9D1, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, CC2D2A, B9D2
TCTN2	CEP290	Yes	binding	10	TMEM216, MKS1, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
TCTN2	CC2D2A	Yes	binding	10	TMEM216, CEP290, MKS1, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, B9D2
TCTN2	TMEM216	Yes	binding	10	CEP290, MKS1, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
TCTN2	TMEM231	Yes	binding	10	TMEM216, CEP290, MKS1, TMEM17, AHI1, TCTN1, TMEM67, B9D1, CC2D2A, B9D2
TCTN2	B9D2	Yes	binding	10	TMEM216, CEP290, MKS1, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A
TCTN2	B9D1	Yes	binding	10	TMEM216, CEP290, MKS1, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, CC2D2A, B9D2
MKS1	CEP290	Yes	binding	10	TMEM216, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
MKS1	CC2D2A	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, B9D2
MKS1	TMEM216	Yes	binding	10	CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
MKS1	TMEM231	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, B9D1, CC2D2A, B9D2
MKS1	B9D2	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A
MKS1	B9D1	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, CC2D2A, B9D2
CEP290	NPHP3	No	-	1	INVS
CEP290	CC2D2A	Yes	binding	10	TMEM216, TMEM17, MKS1, TCTN2, AHI1, TCTN1, TMEM67, TMEM231, B9D1, B9D2
CEP290	TMEM216	Yes	binding	10	TMEM17, MKS1, TCTN2, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
CEP290	TMEM231	Yes	binding	10	TMEM216, TMEM17, MKS1, TCTN2, AHI1, TCTN1, TMEM67, B9D1, CC2D2A, B9D2
CEP290	B9D2	Yes	binding	17	TMEM216, TCTN2, TMEM17, TMEM231, AHI1, TCTN1, MAPRE1, PLK1, CKAP5, CLASP1, PAFAH1B1, TMEM67, B9D1, NDE1, CC2D2A, MKS1, INVS
CEP290	B9D1	Yes	binding	10	TMEM216, TMEM17, MKS1, TCTN2, AHI1, TCTN1, TMEM67, TMEM231, CC2D2A, B9D2
NPHP3	RPGRIP1L	No	-	1	NPHP1
NPHP3	B9D2	No	-	1	INVS
CC2D2A	TMEM216	Yes	binding	10	CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, TMEM231, B9D1, B9D2
CC2D2A	TMEM231	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, B9D1, B9D2
CC2D2A	B9D2	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, TMEM231, B9D1
CC2D2A	B9D1	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, TMEM231, B9D2
TMEM216	TMEM231	Yes	binding	10	CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, B9D1, CC2D2A, B9D2
TMEM216	B9D2	Yes	binding	10	CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, TMEM231, B9D1, CC2D2A
TMEM216	B9D1	Yes	binding	10	CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, TMEM231, CC2D2A, B9D2
TMEM231	B9D2	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, B9D1, CC2D2A
TMEM231	B9D1	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, CC2D2A, B9D2
B9D2	B9D1	Yes	binding	10	TMEM216, CEP290, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, MKS1, TMEM231, CC2D2A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Assembly of the primary cilium	R-HSA-5617833	5.44	10	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
Organelle biogenesis and maintenance	R-HSA-1852241	4.63	10	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.51	9	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
Signal Transduction	R-HSA-162582	1.78	4	KIF14, RPGRIP1L, B9D2, MKS1
RHO GTPase Effectors	R-HSA-195258	4.94	2	KIF14, B9D2
Hedgehog 'off' state	R-HSA-5610787	6.19	2	RPGRIP1L, MKS1
Signaling by Rho GTPases	R-HSA-194315	4.43	2	KIF14, B9D2
Cell Cycle, Mitotic	R-HSA-69278	4.16	2	CEP290, B9D2
Signaling by Hedgehog	R-HSA-5358351	5.79	2	RPGRIP1L, MKS1
Cell Cycle	R-HSA-1640170	3.89	2	CEP290, B9D2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)	-	6.51	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
Organelle biogenesis and maintenance (R-HSA-1852241)	-	4.63	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, CC2D2A, NPHP3, B9D2
Assembly of the primary cilium (R-HSA-5617833)	-	5.44	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
Hedgehog 'off' state (R-HSA-5610787)	-	6.19	0.027	CEP290, RPGRIP1L, MKS1

GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	8	CEP290, TMEM231, MKS1, KIF14, RPGRIP1L, TMEM67, NPHP3, B9D2
protein binding (GO:0005515)	0.46	8	CEP290, TMEM231, MKS1, KIF14, RPGRIP1L, TMEM67, NPHP3, B9D2
cytoskeletal protein binding (GO:0008092)	3.02	4	CEP290, KIF14, B9D2, TMEM67
tubulin binding (GO:0015631)	4.1	3	KIF14, CEP290, B9D2
hydrolase activity (GO:0016787)	1.9	2	KIF14, NPHP3
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	NPHP3, KIF14
pyrophosphatase activity (GO:0016462)	3.04	2	NPHP3, KIF14
microtubule binding (GO:0008017)	4.42	2	KIF14, CEP290
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	NPHP3, KIF14
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	KIF14, NPHP3
catalytic activity (GO:0003824)	1.05	2	KIF14, NPHP3
motor activity (GO:0003774)	4.81	2	KIF14, NPHP3
microtubule motor activity (GO:0003777)	5.34	2	KIF14, NPHP3

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
developmental process (GO:0032502)	1.36	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cellular process (GO:0009987)	0.26	12	TMEM216, KIF14, TCTN2, MKS1, TMEM231, CEP290, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cellular component organization (GO:0016043)	1.24	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
single-organism developmental process (GO:0044767)	1.49	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
single-organism cellular process (GO:0044763)	0.65	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
single-organism process (GO:0044699)	0.48	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cellular component organization or biogenesis (GO:0071840)	1.22	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cell projection organization (GO:0030030)	3.14	11	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
organelle organization (GO:0006996)	2.02	11	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
single-organism organelle organization (GO:1902589)	2.68	11	TMEM216, KIF14, TCTN2, MKS1, TMEM231, CEP290, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cilium organization (GO:0044782)	4.67	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cell projection assembly (GO:0030031)	4.19	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
regulation of cellular process (GO:0050794)	0.5	10	CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cellular component assembly (GO:0022607)	2.14	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
organelle assembly (GO:0070925)	3.75	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cellular component morphogenesis (GO:0032989)	3.5	10	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
cilium assembly (GO:0042384)	4.77	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cellular developmental process (GO:0048869)	1.82	10	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
biological regulation (GO:0065007)	0.39	10	CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
anatomical structure morphogenesis (GO:0009653)	2.53	10	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
regulation of biological process (GO:0050789)	0.45	10	CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cell projection morphogenesis (GO:0048858)	4.05	9	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, CC2D2A, NPHP3
cilium morphogenesis (GO:0060271)	5.54	9	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
cell part morphogenesis (GO:0032990)	3.99	9	TMEM216, CEP290, TCTN2, MKS1, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
anatomical structure development (GO:0048856)	1.58	7	CEP290, MKS1, B9D1, KIF14, RPGRIP1L, CC2D2A, NPHP3
animal organ development (GO:0048513)	2.53	6	CEP290, MKS1, B9D1, RPGRIP1L, CC2D2A, NPHP3
multicellular organismal process (GO:0032501)	1.45	5	B9D1, NPHP3, CC2D2A, MKS1, RPGRIP1L
single-multicellular organism process (GO:0044707)	1.78	5	B9D1, NPHP3, CC2D2A, RPGRIP1L, MKS1
signal transduction (GO:0007165)	1.28	5	B9D1, CC2D2A, NPHP3, TMEM231, TCTN2
cell surface receptor signaling pathway (GO:0007166)	2.09	5	B9D1, CC2D2A, NPHP3, TMEM231, TCTN2
embryonic morphogenesis (GO:0048598)	3.72	4	NPHP3, RPGRIP1L, B9D1, MKS1
pattern specification process (GO:0007389)	3.79	4	NPHP3, CC2D2A, RPGRIP1L, MKS1
smoothened signaling pathway (GO:0007224)	5.45	4	B9D1, CC2D2A, TMEM231, TCTN2
regulation of signal transduction (GO:0009966)	1.84	4	KIF14, RPGRIP1L, NPHP3, MKS1
determination of left/right symmetry (GO:0007368)	5.38	4	NPHP3, CC2D2A, MKS1, RPGRIP1L
regulation of signaling (GO:0023051)	1.72	4	KIF14, NPHP3, MKS1, RPGRIP1L
regulation of response to stimulus (GO:0048583)	1.54	4	NPHP3, RPGRIP1L, KIF14, MKS1
determination of bilateral symmetry (GO:0009855)	5.37	4	CC2D2A, RPGRIP1L, NPHP3, MKS1
specification of symmetry (GO:0009799)	5.36	4	NPHP3, RPGRIP1L, CC2D2A, MKS1
negative regulation of biological process (GO:0048519)	1.33	4	KIF14, NPHP3, TMEM67, RPGRIP1L
regulation of cell communication (GO:0010646)	1.73	4	KIF14, RPGRIP1L, NPHP3, MKS1
negative regulation of cellular process (GO:0048523)	1.41	4	KIF14, NPHP3, RPGRIP1L, TMEM67
microtubule-based process (GO:0007017)	3.54	3	KIF14, NPHP3, CC2D2A
sensory organ development (GO:0007423)	4.82	3	CC2D2A, B9D1, RPGRIP1L
regulation of developmental process (GO:0050793)	2.1	3	KIF14, NPHP3, MKS1
regulation of multicellular organismal development (GO:2000026)	2.31	3	KIF14, NPHP3, MKS1
kidney development (GO:0001822)	4.79	3	NPHP3, CEP290, RPGRIP1L
regulation of nervous system development (GO:0051960)	3.1	3	KIF14, NPHP3, MKS1
cell cycle process (GO:0022402)	2.75	3	KIF14, CEP290, B9D2
regulation of multicellular organismal process (GO:0051239)	1.87	3	NPHP3, KIF14, MKS1
eye development (GO:0001654)	5.07	3	CC2D2A, B9D1, RPGRIP1L
regulation of localization (GO:0032879)	1.94	3	KIF14, CEP290, B9D1
camera-type eye development (GO:0043010)	5.36	3	CC2D2A, RPGRIP1L, B9D1
tube formation (GO:0035148)	4.98	2	CC2D2A, MKS1
regulation of smoothened signaling pathway (GO:0008589)	5.62	2	RPGRIP1L, MKS1
positive regulation of metabolic process (GO:0009893)	1.74	2	KIF14, CEP290
regulation of metabolic process (GO:0019222)	1.02	2	KIF14, CEP290
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	NPHP3, MKS1
embryonic organ development (GO:0048568)	4.86	2	CC2D2A, MKS1
negative regulation of response to stimulus (GO:0048585)	2.52	2	NPHP3, RPGRIP1L
regulation of cellular metabolic process (GO:0031323)	1.07	2	KIF14, CEP290
mitotic cell cycle process (GO:1903047)	3.12	2	KIF14, CEP290
negative regulation of cellular component organization (GO:0051129)	3.35	2	KIF14, TMEM67
regulation of cellular component organization (GO:0051128)	2.01	2	KIF14, TMEM67
metabolic process (GO:0008152)	0.58	2	KIF14, TMEM67
negative regulation of signaling (GO:0023057)	2.65	2	NPHP3, RPGRIP1L
regulation of Wnt signaling pathway (GO:0030111)	3.98	2	NPHP3, MKS1
head development (GO:0060322)	7.02	2	RPGRIP1L, MKS1
microtubule cytoskeleton organization (GO:0000226)	4.13	2	KIF14, CC2D2A
(GO:1905330)	4.56	2	NPHP3, MKS1
modification-dependent macromolecule catabolic process (GO:0043632)	3.69	2	KIF14, TMEM67
multicellular organism development (GO:0007275)	2.54	2	B9D1, RPGRIP1L
regulation of protein localization (GO:0032880)	2.88	2	CEP290, B9D1
morphogenesis of an epithelium (GO:0002009)	4.08	2	NPHP3, MKS1
organic substance catabolic process (GO:1901575)	2.45	2	KIF14, TMEM67
cellular macromolecule catabolic process (GO:0044265)	3.19	2	KIF14, TMEM67
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	2	KIF14, CEP290
cellular macromolecule metabolic process (GO:0044260)	0.93	2	KIF14, TMEM67
regulation of non-canonical Wnt signaling pathway (GO:2000050)	6.78	2	NPHP3, MKS1
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)	4.16	2	KIF14, TMEM67
regulation of cell cycle process (GO:0010564)	3.5	2	KIF14, TMEM67
microtubule-based movement (GO:0007018)	4.39	2	KIF14, NPHP3
macromolecule catabolic process (GO:0009057)	3.0	2	KIF14, TMEM67
organic substance metabolic process (GO:0071704)	0.63	2	KIF14, TMEM67
motile primary cilium assembly (GO:1903887)	8.34	2	CC2D2A, MKS1
embryo development ending in birth or egg hatching (GO:0009792)	4.35	2	B9D1, RPGRIP1L
tissue morphogenesis (GO:0048729)	3.87	2	NPHP3, MKS1
positive regulation of biological process (GO:0048518)	1.2	2	KIF14, CEP290
proteolysis (GO:0006508)	2.73	2	KIF14, TMEM67
neural tube closure (GO:0001843)	5.38	2	CC2D2A, MKS1
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	KIF14, CEP290
embryonic brain development (GO:1990403)	7.78	2	CC2D2A, MKS1
tube morphogenesis (GO:0035239)	4.35	2	NPHP3, MKS1
nonmotile primary cilium assembly (GO:0035058)	6.51	2	CC2D2A, MKS1
regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	7.24	2	NPHP3, MKS1
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	2	KIF14, TMEM67
establishment of protein localization (GO:0045184)	2.53	2	KIF14, CEP290
regulation of macromolecule metabolic process (GO:0060255)	1.08	2	KIF14, CEP290
transport (GO:0006810)	1.51	2	KIF14, CEP290
modification-dependent protein catabolic process (GO:0019941)	3.71	2	KIF14, TMEM67
cellular catabolic process (GO:0044248)	2.62	2	KIF14, TMEM67
embryonic digit morphogenesis (GO:0042733)	5.69	2	B9D1, MKS1
tube closure (GO:0060606)	5.36	2	CC2D2A, MKS1
regulation of cell differentiation (GO:0045595)	2.42	2	NPHP3, KIF14
in utero embryonic development (GO:0001701)	4.4	2	B9D1, RPGRIP1L
movement of cell or subcellular component (GO:0006928)	2.61	2	KIF14, NPHP3
protein catabolic process (GO:0030163)	3.93	2	KIF14, TMEM67
regulation of embryonic development (GO:0045995)	4.98	2	NPHP3, MKS1
olfactory bulb development (GO:0021772)	6.68	2	KIF14, RPGRIP1L
tube development (GO:0035295)	4.41	2	NPHP3, MKS1
establishment of localization (GO:0051234)	1.48	2	KIF14, CEP290
catabolic process (GO:0009056)	2.38	2	KIF14, TMEM67
localization (GO:0051179)	1.4	2	KIF14, CEP290
regulation of primary metabolic process (GO:0080090)	1.08	2	KIF14, CEP290
primary metabolic process (GO:0044238)	0.69	2	KIF14, TMEM67
cytoskeleton organization (GO:0007010)	3.22	2	KIF14, CC2D2A
negative regulation of signal transduction (GO:0009968)	2.75	2	NPHP3, RPGRIP1L
regulation of establishment of planar polarity (GO:0090175)	5.02	2	NPHP3, MKS1
regulation of cell cycle (GO:0051726)	2.93	2	KIF14, TMEM67
protein metabolic process (GO:0019538)	1.45	2	KIF14, TMEM67
proteasomal protein catabolic process (GO:0010498)	4.12	2	KIF14, TMEM67
cellular metabolic process (GO:0044237)	0.69	2	KIF14, TMEM67
macromolecule metabolic process (GO:0043170)	0.83	2	KIF14, TMEM67
ubiquitin-dependent protein catabolic process (GO:0006511)	3.72	2	KIF14, TMEM67
negative regulation of cell communication (GO:0010648)	2.66	2	NPHP3, RPGRIP1L
regulation of organ morphogenesis (GO:2000027)	4.22	2	NPHP3, MKS1
system development (GO:0048731)	2.92	2	B9D1, MKS1
chordate embryonic development (GO:0043009)	4.38	2	B9D1, RPGRIP1L
embryo development (GO:0009790)	4.2	2	B9D1, RPGRIP1L
regulation of canonical Wnt signaling pathway (GO:0060828)	4.26	2	NPHP3, MKS1
positive regulation of cellular process (GO:0048522)	1.3	2	KIF14, CEP290

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cellular component assembly (GO:0022607)	-	2.14	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cell projection organization (GO:0030030)	-	3.14	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cell projection assembly (GO:0030031)	-	4.19	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cellular component assembly involved in morphogenesis (GO:0010927)	-	4.29	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
establishment or maintenance of cell polarity (GO:0007163)	NEW	5.0	0.023	CEP290, NPHP3, RPGRIP1L, TMEM67
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.0	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
in utero embryonic development (GO:0001701)	-	4.4	0.021	B9D1, CEP290, RPGRIP1L, TMEM67, B9D2
cellular developmental process (GO:0048869)	-	1.82	0.0	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, B9D1, NPHP3, CC2D2A
vasculature development (GO:0001944)	NEW	6.04	0.017	CEP290, B9D1, B9D2
kidney development (GO:0001822)	-	4.79	0.019	NPHP3, CEP290, RPGRIP1L
cellular component organization (GO:0016043)	-	1.24	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cellular component morphogenesis (GO:0032989)	-	3.5	0.0	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, B9D1, NPHP3, CC2D2A, B9D2
embryo development ending in birth or egg hatching (GO:0009792)	-	4.35	0.026	B9D1, CEP290, RPGRIP1L, TMEM67, B9D2
central nervous system neuron axonogenesis (GO:0021955)	NEW	6.51	0.006	TCTN2, TMEM67, B9D2
chordate embryonic development (GO:0043009)	-	4.38	0.022	B9D1, CEP290, RPGRIP1L, TMEM67, B9D2
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
developmental process (GO:0032502)	-	1.36	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cilium assembly (GO:0042384)	-	4.77	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cilium morphogenesis (GO:0060271)	-	5.54	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM67, B9D1, NPHP3, CC2D2A
single-organism developmental process (GO:0044767)	-	1.49	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
eye development (GO:0001654)	-	5.07	0.008	B9D1, CEP290, B9D2, RPGRIP1L
organelle assembly (GO:0070925)	-	3.75	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cell part morphogenesis (GO:0032990)	-	3.99	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM67, B9D1, NPHP3, CC2D2A, B9D2
cell projection morphogenesis (GO:0048858)	-	4.05	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM67, B9D1, CC2D2A, NPHP3, B9D2
sensory organ development (GO:0007423)	-	4.82	0.022	B9D1, CEP290, B9D2, RPGRIP1L
smoothened signaling pathway (GO:0007224)	-	5.45	0.0	B9D1, CEP290, CC2D2A, TMEM231, TCTN2
photoreceptor cell outer segment organization (GO:0035845)	NEW	7.65	0.01	CEP290, B9D2
cilium organization (GO:0044782)	-	4.67	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
organelle (GO:0043226)	0.4	12	TMEM216, CEP290, TCTN2, MKS1, TMEM231, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
organelle part (GO:0044422)	0.79	12	TMEM216, KIF14, TCTN2, MKS1, TMEM231, CEP290, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
protein complex (GO:0043234)	1.51	11	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, TMEM231, B9D1, NPHP3, CC2D2A, B9D2
intracellular part (GO:0044424)	0.28	11	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
cell projection (GO:0042995)	2.47	11	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, NPHP3, CC2D2A, B9D2
macromolecular complex (GO:0032991)	1.35	11	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, TMEM231, B9D1, NPHP3, CC2D2A, B9D2
cytoplasm (GO:0005737)	1.01	10	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cytoskeleton (GO:0005856)	2.55	10	TMEM216, KIF14, TCTN2, MKS1, CEP290, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	10	TMEM216, KIF14, TCTN2, MKS1, CEP290, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cell projection part (GO:0044463)	2.97	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
cytoplasmic part (GO:0044444)	0.82	10	TMEM216, CEP290, B9D1, MKS1, KIF14, TMEM67, RPGRIP1L, NPHP3, CC2D2A, B9D2
intracellular organelle (GO:0043229)	0.51	10	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
non-membrane-bounded organelle (GO:0043228)	1.76	10	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
ciliary part (GO:0044441)	4.05	10	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
ciliary transition zone (GO:0035869)	6.62	9	TMEM216, CEP290, TMEM231, MKS1, RPGRIP1L, TMEM67, B9D1, CC2D2A, B9D2
MKS complex (GO:0036038)	7.32	9	TMEM216, CEP290, TCTN2, MKS1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
membrane (GO:0016020)	0.68	9	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, TMEM231, B9D1, B9D2
cytosol (GO:0005829)	1.68	9	TMEM216, KIF14, B9D1, MKS1, CEP290, RPGRIP1L, NPHP3, CC2D2A, B9D2
cilium (GO:0005929)	3.89	9	TMEM216, CEP290, TMEM231, MKS1, TMEM67, RPGRIP1L, NPHP3, CC2D2A, B9D2
intracellular organelle part (GO:0044446)	0.81	8	CEP290, B9D1, MKS1, KIF14, RPGRIP1L, TMEM67, NPHP3, B9D2
cytoskeletal part (GO:0044430)	2.49	8	CEP290, B9D1, MKS1, KIF14, TMEM67, RPGRIP1L, NPHP3, B9D2
centrosome (GO:0005813)	3.75	6	CEP290, MKS1, B9D1, RPGRIP1L, TMEM67, B9D2
microtubule organizing center (GO:0005815)	3.42	6	CEP290, MKS1, B9D1, RPGRIP1L, TMEM67, B9D2
ciliary basal body (GO:0036064)	5.36	4	B9D1, RPGRIP1L, MKS1, B9D2
intracellular membrane-bounded organelle (GO:0043231)	0.6	4	CEP290, KIF14, B9D2, TMEM67
integral component of membrane (GO:0016021)	1.14	4	TMEM216, TMEM231, TCTN2, TMEM67
membrane part (GO:0044425)	0.95	4	TMEM216, TMEM231, TCTN2, TMEM67
membrane-bounded organelle (GO:0043227)	0.47	4	CEP290, KIF14, B9D2, TMEM67
intrinsic component of membrane (GO:0031224)	1.13	4	TMEM216, TMEM231, TMEM67, TCTN2
plasma membrane region (GO:0098590)	2.97	3	TMEM231, TMEM67, TCTN2
organelle membrane (GO:0031090)	1.97	3	TMEM231, TMEM67, TCTN2
ciliary membrane (GO:0060170)	5.43	3	TMEM231, TCTN2, TMEM67
nucleus (GO:0005634)	1.07	3	KIF14, CEP290, B9D2
cell projection membrane (GO:0031253)	4.11	3	TMEM231, TCTN2, TMEM67
plasma membrane (GO:0005886)	1.39	3	KIF14, TMEM231, TMEM67
plasma membrane part (GO:0044459)	1.95	3	TMEM231, TMEM67, TCTN2
bounding membrane of organelle (GO:0098588)	2.39	3	TMEM231, TMEM67, TCTN2
kinesin complex (GO:0005871)	5.74	2	NPHP3, KIF14
primary cilium (GO:0072372)	4.64	2	NPHP3, CEP290
microtubule associated complex (GO:0005875)	4.79	2	KIF14, NPHP3
centriole (GO:0005814)	5.15	2	CEP290, MKS1
microtubule organizing center part (GO:0044450)	4.8	2	CEP290, MKS1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein complex (GO:0043234)	-	1.51	0.0	TMEM216, KIF14, TCTN2, MKS1, CEP290, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
ciliary transition zone (GO:0035869)	-	6.62	0.0	B9D1, CC2D2A, B9D2, TMEM231
TCTN-B9D complex (GO:0036038)	-	7.32	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
cell projection part (GO:0044463)	-	2.97	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.0	TMEM216, CEP290, TCTN2, MKS1, KIF14, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.0	TMEM216, KIF14, TCTN2, MKS1, CEP290, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
ciliary basal body (GO:0036064)	-	5.36	0.0	B9D1, CEP290, RPGRIP1L, MKS1, B9D2
ciliary membrane (GO:0060170)	-	5.43	0.039	CEP290, TMEM231, TMEM67, B9D2
centrosome (GO:0005813)	-	3.75	0.002	CEP290, MKS1, B9D1, RPGRIP1L, TMEM67, B9D2
cytoskeleton (GO:0005856)	-	2.55	0.001	TMEM216, KIF14, B9D1, TCTN2, CEP290, TMEM67, CC2D2A, B9D2
cilium (GO:0005929)	-	3.89	0.009	TMEM216, CEP290, NPHP3, B9D2, RPGRIP1L
microtubule organizing center (GO:0005815)	-	3.42	0.0	CEP290, MKS1, B9D1, RPGRIP1L, TMEM67, B9D2
cytoskeletal part (GO:0044430)	-	2.49	0.001	KIF14, B9D1, MKS1, CEP290, TMEM67, RPGRIP1L, B9D2
ciliary part (GO:0044441)	-	4.05	0.0	TMEM216, CEP290, TCTN2, MKS1, TMEM231, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2
macromolecular complex (GO:0032991)	-	1.35	0.002	TMEM216, KIF14, TCTN2, MKS1, CEP290, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
organelle part (GO:0044422)	-	0.79	0.009	TMEM216, KIF14, TCTN2, MKS1, TMEM231, CEP290, TMEM67, RPGRIP1L, B9D1, CC2D2A, B9D2