Disease table of MENTAL RETARDATION, AUTOSOMAL RECESSIVE OMIM ID: PS249500

Gene-disease associations table

Gene	Associated with MENTAL RETARDATION, AUTOSOMAL RECESSIVE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
PGAP1	ClinVar, OMIM	HGNC link	2q33.1	1	PS249500
TUSC3	ClinVar, OMIM	HGNC link	8p22	1	PS249500
MED23	ClinVar, OMIM, HUMSAVAR	HGNC link	6q23.2	1	PS249500
FMN2	ClinVar, OMIM	HGNC link	1q43	1	PS249500
MAN1B1	ClinVar, OMIM, HUMSAVAR	HGNC link	9q34.3	1	PS249500
EDC3	OMIM, HUMSAVAR	HGNC link	15q24.1	1	PS249500
CC2D1A	OMIM	HGNC link	19p13.12	1	PS249500
KIAA1033	ClinVar, OMIM, HUMSAVAR	HGNC link	12q23.3	1	PS249500
CRADD	ClinVar, OMIM, HUMSAVAR	HGNC link	12q22	1	PS249500
NDST1	ClinVar, OMIM, HUMSAVAR	HGNC link	5q33.1	1	PS249500
LINS1	OMIM	HGNC link	15q26.3	1	PS249500
TECR	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.12	1	PS249500
CRBN	ClinVar, OMIM	HGNC link	3p26.2	1	PS249500
LMAN2L	ClinVar, OMIM	HGNC link	2q11.2	1	PS249500
HNMT	ClinVar, OMIM	HGNC link	2q22.1	2	PS249500, 600807
ST3GAL3	ClinVar, OMIM, HUMSAVAR	HGNC link	1p34.1	2	PS308350, PS249500
PIGG	ClinVar	HGNC link	4p16.3	1	PS249500
PRSS12	OMIM	HGNC link	4q26	1	PS249500
ADAT3	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.3	1	PS249500
HERC2	ClinVar, OMIM, HUMSAVAR	HGNC link	15q13.1	2	PS227220, PS249500
KPTN	ClinVar, OMIM	HGNC link	19q13.32	1	PS249500
TRAPPC9	ClinVar, OMIM	HGNC link	8q24.3	1	PS249500
TAF2	ClinVar, OMIM, HUMSAVAR	HGNC link	8q24.12	1	PS249500
GPT2	ClinVar, OMIM, HUMSAVAR	HGNC link	16q11.2	1	PS249500
SLC6A17	ClinVar, OMIM, HUMSAVAR	HGNC link	1p13.3	1	PS249500
GRIK2	ClinVar, OMIM	HGNC link	6q16.3	1	PS249500
NSUN2	ClinVar, OMIM, HUMSAVAR	HGNC link	5p15.31	1	PS249500
METTL23	ClinVar, OMIM	HGNC link	17q25.1	1	PS249500
ANK3	ClinVar, OMIM	HGNC link	10q21.2	1	PS249500
FBXO31	OMIM	HGNC link	16q24.2	1	PS249500
TTI2	ClinVar, OMIM, HUMSAVAR	HGNC link	8p12	1	PS249500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
19p13.12	2	TECR, CC2D1A

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
8q24	2	TRAPPC9, TAF2
19p13	3	TECR, CC2D1A, ADAT3

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12q2	2	CRADD, KIAA1033
15q2	2	EDC3, LINS1
19p1	3	TECR, CC2D1A, ADAT3
8q2	2	TRAPPC9, TAF2

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
15q	3	EDC3, HERC2, LINS1
2q	3	PGAP1, LMAN2L, HNMT
12q	2	CRADD, KIAA1033
19p	3	TECR, CC2D1A, ADAT3
6q	2	MED23, GRIK2
16q	2	GPT2, FBXO31
8p	2	TTI2, TUSC3
8q	2	TRAPPC9, TAF2
1p	2	SLC6A17, ST3GAL3

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	2	CRADD, KIAA1033
15	3	EDC3, HERC2, LINS1
16	2	GPT2, FBXO31
19	4	KPTN, TECR, CC2D1A, ADAT3
1	3	ST3GAL3, SLC6A17, FMN2
2	3	PGAP1, LMAN2L, HNMT
5	2	NDST1, NSUN2
4	2	PIGG, PRSS12
6	2	MED23, GRIK2
8	4	TRAPPC9, TAF2, TUSC3, TTI2

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
MED23	YES	2	KISS1, TXNIP	0

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
ST3GAL3	YES	1	MYC	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PGAP1	TUSC3	No	2	HTR3C, MCOLN3
PGAP1	HERC2	No	1	SIRT3
MED23	EDC3	No	1	NTRK1
MED23	CC2D1A	No	1	NCOA2
MED23	KIAA1033	No	2	NTRK1, ROCK1
MED23	TECR	No	7	VDAC2, ABCE1, PAXIP1, DYRK1B, ESR1, NTRK1, SSR1
MED23	CRBN	No	2	KDM1A, PSMA2
MED23	HERC2	No	5	VDAC2, PHKG2, LCP1, CDK8, PHKB
MED23	TRAPPC9	No	2	NTRK1, NOTCH1
MED23	TAF2	No	3	MED26, ELAVL1, ESR1
MED23	NSUN2	No	3	NTRK1, PPP1R12A, RPL35
MED23	METTL23	No	1	BAG6
MED23	TTI2	No	2	TRRAP, ELAVL1
FMN2	KPTN	Yes	1	BTN2A1
MAN1B1	NSUN2	No	1	CUL5
EDC3	CC2D1A	No	3	CEP19, STIL, XPO1
EDC3	KIAA1033	No	2	NTRK1, XPO1
EDC3	TECR	No	2	NTRK1, CLTC
EDC3	HERC2	No	1	UBC
EDC3	TRAPPC9	No	1	NTRK1
EDC3	TAF2	No	1	TERF2
EDC3	NSUN2	No	1	NTRK1
EDC3	METTL23	No	1	UBC
CC2D1A	KIAA1033	No	2	CEP128, XPO1
CC2D1A	CRADD	No	1	CRYAB
CC2D1A	HERC2	No	6	CHMP4B, NIN, CEP170, CEP104, CEP162, PCM1
CC2D1A	TRAPPC9	No	1	CRYAB
KIAA1033	TECR	No	1	NTRK1
KIAA1033	HERC2	No	2	RPA3, RPA1
KIAA1033	KPTN	No	1	ELP2
KIAA1033	TRAPPC9	No	1	NTRK1
KIAA1033	NSUN2	No	2	NTRK1, RPA1
KIAA1033	ANK3	No	1	SMAD2
CRADD	CRBN	No	1	APPL2
CRADD	PIGG	No	1	APP
CRADD	HERC2	No	1	RIPK1
CRADD	KPTN	No	1	APP
CRADD	TRAPPC9	No	2	CRYAB, APP
CRADD	GPT2	No	1	APP
NDST1	HERC2	No	1	HLA-E
TECR	HNMT	No	1	DSP
TECR	HERC2	No	2	VDAC2, ARAF
TECR	TRAPPC9	No	1	NTRK1
TECR	TAF2	No	1	ESR1
TECR	GPT2	No	1	CUL3
TECR	NSUN2	No	4	NTRK1, CUL3, CAND1, EGFR
TECR	METTL23	No	1	UBL4A
TECR	ANK3	No	1	RNF2
TECR	TTI2	No	1	EGFR
CRBN	HERC2	No	1	PSMB4
CRBN	NSUN2	No	1	COPS5
CRBN	FBXO31	No	2	COPS5, RBX1
LMAN2L	HERC2	No	1	ZDHHC17
HNMT	TAF2	No	1	TERF1
ST3GAL3	HERC2	No	1	ZBTB5
PIGG	KPTN	No	1	APP
PIGG	TRAPPC9	No	1	APP
PIGG	GPT2	No	1	APP
HERC2	KPTN	No	3	USP19, GTSE1, MAVS
HERC2	GPT2	No	1	USP20
HERC2	NSUN2	No	4	AURKB, SIRT7, CCDC8, RPA1
HERC2	METTL23	No	4	TUBB3, UBC, DNAJA1, CSTA
HERC2	ANK3	No	1	MAPK6
KPTN	TRAPPC9	No	1	APP
KPTN	GPT2	No	1	APP
TRAPPC9	GPT2	No	1	APP
TRAPPC9	NSUN2	No	1	NTRK1
TAF2	TTI2	No	1	ELAVL1
GPT2	NSUN2	No	1	CUL3
NSUN2	METTL23	No	1	UGGT1
NSUN2	FBXO31	No	2	CUL1, COPS5
NSUN2	TTI2	No	1	EGFR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MED23	KIAA1033	No	-	1	UBC
MED23	TECR	No	-	1	UBC
MED23	CRBN	No	-	1	UBC
MED23	TAF2	No	-	1	ESR1
MED23	NSUN2	No	-	1	UBC
MED23	TTI2	No	-	1	UBC
KIAA1033	TECR	No	-	1	UBC
KIAA1033	CRBN	No	-	1	UBC
KIAA1033	NSUN2	No	-	1	UBC
KIAA1033	TTI2	No	-	1	UBC
TECR	CRBN	No	-	1	UBC
TECR	NSUN2	No	-	1	UBC
TECR	TTI2	No	-	1	UBC
CRBN	NSUN2	No	-	1	UBC
CRBN	FBXO31	No	-	2	FBXW5, RBX1
CRBN	TTI2	No	-	1	UBC
NSUN2	TTI2	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
MED23	TAF2	No	-	2	TRRAP, KAT2A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TECR	HNMT	No	1	DSP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
TUSC3	CRBN	Yes	2	CRBN, TUSC3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	6	GPT2, NDST1, PGAP1, TUSC3, ST3GAL3, MAN1B1
Protein processing in endoplasmic reticulum	hsa04141	5.35	2	TUSC3, MAN1B1
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	hsa00563	8.07	2	PGAP1, PIGG
N-Glycan biosynthesis	hsa00510	7.07	2	TUSC3, MAN1B1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Glycan biosynthesis and metabolism	NEW	4.78	0.003	ST3GAL3, TUSC3, PGAP1, NDST1, PIGG, MAN1B1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Post-translational protein modification	R-HSA-597592	4.54	6	ST3GAL3, TUSC3, PGAP1, HERC2, PIGG, MAN1B1
Metabolism of proteins	R-HSA-392499	3.41	6	ST3GAL3, TUSC3, PGAP1, HERC2, PIGG, MAN1B1
Metabolism	R-HSA-1430728	2.34	5	GPT2, MED23, NDST1, TECR, ST3GAL3
Gene Expression	R-HSA-74160	2.72	3	MED23, TAF2, EDC3
Asparagine N-linked glycosylation	R-HSA-446203	6.1	3	TUSC3, MAN1B1, ST3GAL3
Post-translational modification: synthesis of GPI-anchored proteins	R-HSA-163125	8.28	2	PGAP1, PIGG
Metabolism of carbohydrates	R-HSA-71387	4.93	2	NDST1, ST3GAL3
Developmental Biology	R-HSA-1266738	3.48	2	MED23, ANK3
Fatty acid, triacylglycerol, and ketone body metabolism	R-HSA-535734	5.44	2	MED23, TECR
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	2	MED23, TECR
Glycosaminoglycan metabolism	R-HSA-1630316	6.04	2	NDST1, ST3GAL3
Disease	R-HSA-1643685	3.33	2	TAF2, MAN1B1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Post-translational protein modification (R-HSA-597592)	-	4.54	0.035	ST3GAL3, TUSC3, PGAP1, HERC2, PIGG, MAN1B1

GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
catalytic activity (GO:0003824)	1.05	18	FBXO31, CRBN, PIGG, GPT2, HNMT, NDST1, PGAP1, HERC2, TECR, ADAT3, PRSS12, TUSC3, TAF2, ST3GAL3, METTL23, EDC3, NSUN2, MAN1B1
binding (GO:0005488)	0.18	18	CRBN, LMAN2L, FBXO31, GPT2, CRADD, MED23, HERC2, FMN2, GRIK2, CC2D1A, KPTN, TECR, MAN1B1, ANK3, ADAT3, EDC3, NSUN2, TAF2
protein binding (GO:0005515)	0.46	13	FMN2, CRBN, KPTN, FBXO31, MED23, HERC2, CC2D1A, GRIK2, TECR, EDC3, ANK3, CRADD, TAF2
transferase activity (GO:0016740)	1.95	10	FBXO31, ST3GAL3, GPT2, TUSC3, METTL23, NDST1, HNMT, HERC2, PIGG, NSUN2
hydrolase activity (GO:0016787)	1.9	7	CRBN, MAN1B1, PGAP1, NDST1, PRSS12, TAF2, EDC3
ion binding (GO:0043167)	1.36	7	CRBN, GPT2, HERC2, ADAT3, MAN1B1, LMAN2L, TAF2
cation binding (GO:0043169)	1.4	6	CRBN, MAN1B1, HERC2, ADAT3, TAF2, LMAN2L
metal ion binding (GO:0046872)	1.41	6	CRBN, MAN1B1, HERC2, ADAT3, TAF2, LMAN2L
organic cyclic compound binding (GO:0097159)	1.05	4	CC2D1A, NSUN2, TAF2, EDC3
heterocyclic compound binding (GO:1901363)	1.06	4	CC2D1A, NSUN2, TAF2, EDC3
nucleic acid binding (GO:0003676)	1.44	4	CC2D1A, NSUN2, TAF2, EDC3
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	3	TUSC3, SLC6A17, GRIK2
substrate-specific transporter activity (GO:0022892)	2.72	3	TUSC3, SLC6A17, GRIK2
transition metal ion binding (GO:0046914)	2.48	3	HERC2, ADAT3, TAF2
cytoskeletal protein binding (GO:0008092)	3.02	3	FMN2, ANK3, KPTN
transporter activity (GO:0005215)	2.57	3	TUSC3, SLC6A17, GRIK2
enzyme binding (GO:0019899)	2.27	3	CRADD, HERC2, GRIK2
peptidase activity, acting on L-amino acid peptides (GO:0070011)	3.26	3	CRBN, PRSS12, TAF2
ion transmembrane transporter activity (GO:0015075)	3.04	3	TUSC3, SLC6A17, GRIK2
transmembrane transporter activity (GO:0022857)	2.82	3	TUSC3, SLC6A17, GRIK2
transferase activity, transferring one-carbon groups (GO:0016741)	4.3	3	NSUN2, HNMT, METTL23
zinc ion binding (GO:0008270)	2.66	3	HERC2, ADAT3, TAF2
methyltransferase activity (GO:0008168)	4.35	3	NSUN2, HNMT, METTL23
peptidase activity (GO:0008233)	3.23	3	CRBN, PRSS12, TAF2
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	HERC2, GRIK2
molecular transducer activity (GO:0060089)	2.32	2	PRSS12, GRIK2
nucleic acid binding transcription factor activity (GO:0001071)	2.65	2	CC2D1A, TAF2
signal transducer activity (GO:0004871)	2.28	2	CC2D1A, GRIK2
DNA binding (GO:0003677)	1.92	2	CC2D1A, TAF2
ubiquitin-like protein transferase activity (GO:0019787)	3.69	2	HERC2, FBXO31
sequence-specific DNA binding (GO:0043565)	2.79	2	CC2D1A, TAF2
actin binding (GO:0003779)	3.74	2	FMN2, KPTN
transcription factor activity, transcription factor binding (GO:0000989)	3.36	2	MED23, TAF2
transcription factor activity, protein binding (GO:0000988)	3.35	2	MED23, TAF2
metal ion transmembrane transporter activity (GO:0046873)	3.71	2	TUSC3, SLC6A17
identical protein binding (GO:0042802)	2.63	2	GRIK2, EDC3
RNA binding (GO:0003723)	2.36	2	NSUN2, EDC3
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	2	TUSC3, SLC6A17
S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)	4.81	2	NSUN2, HNMT
poly(A) RNA binding (GO:0044822)	2.69	2	NSUN2, EDC3
cation transmembrane transporter activity (GO:0008324)	3.32	2	TUSC3, SLC6A17
regulatory region nucleic acid binding (GO:0001067)	3.03	2	CC2D1A, TAF2
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	2	PGAP1, EDC3
protein domain specific binding (GO:0019904)	3.32	2	CRADD, GRIK2
ubiquitin-protein transferase activity (GO:0004842)	3.73	2	HERC2, FBXO31
binding, bridging (GO:0060090)	4.57	2	CRADD, ANK3
transcription regulatory region DNA binding (GO:0044212)	3.03	2	CC2D1A, TAF2
protein binding, bridging (GO:0030674)	4.68	2	CRADD, ANK3
ubiquitin protein ligase binding (GO:0031625)	4.17	2	HERC2, GRIK2
nuclease activity (GO:0004518)	4.33	2	PGAP1, EDC3
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	2	CC2D1A, TAF2
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	2	CC2D1A, TAF2
transferase activity, transferring glycosyl groups (GO:0016757)	4.08	2	TUSC3, ST3GAL3
regulatory region DNA binding (GO:0000975)	3.03	2	CC2D1A, TAF2
receptor activity (GO:0004872)	2.32	2	PRSS12, GRIK2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	27	KPTN, GPT2, TRAPPC9, TUSC3, HNMT, NSUN2, CC2D1A, PGAP1, NDST1, PRSS12, ST3GAL3, ANK3, CRADD, MAN1B1, TAF2, FBXO31, MED23, HERC2, CRBN, ADAT3, FMN2, PIGG, LMAN2L, KIAA1033, TECR, GRIK2, EDC3
metabolic process (GO:0008152)	0.58	20	FBXO31, CRBN, ST3GAL3, GPT2, MAN1B1, NDST1, MED23, TUSC3, TECR, ADAT3, CC2D1A, PRSS12, HERC2, EDC3, PIGG, HNMT, METTL23, NSUN2, PGAP1, TAF2
single-organism process (GO:0044699)	0.48	20	FBXO31, ST3GAL3, GPT2, NDST1, HNMT, TUSC3, PGAP1, HERC2, TECR, GRIK2, KPTN, PRSS12, CRADD, SLC6A17, PIGG, FMN2, ANK3, NSUN2, TRAPPC9, MAN1B1
primary metabolic process (GO:0044238)	0.69	19	PIGG, CRBN, FBXO31, GPT2, NDST1, TUSC3, PGAP1, HERC2, TECR, ADAT3, CC2D1A, PRSS12, MAN1B1, ST3GAL3, HNMT, EDC3, NSUN2, MED23, TAF2
organic substance metabolic process (GO:0071704)	0.63	19	FBXO31, CC2D1A, ST3GAL3, GPT2, HNMT, NDST1, PGAP1, TUSC3, TECR, ADAT3, PRSS12, HERC2, MAN1B1, PIGG, CRBN, EDC3, NSUN2, MED23, TAF2
single-organism cellular process (GO:0044763)	0.65	18	FMN2, ST3GAL3, GPT2, HNMT, NDST1, TRAPPC9, CRADD, TUSC3, TECR, GRIK2, KPTN, PRSS12, FBXO31, PIGG, ANK3, NSUN2, PGAP1, MAN1B1
cellular metabolic process (GO:0044237)	0.69	18	FBXO31, CRBN, ST3GAL3, GPT2, NDST1, TUSC3, PGAP1, HERC2, CC2D1A, ADAT3, TECR, MAN1B1, PIGG, HNMT, EDC3, NSUN2, MED23, TAF2
macromolecule metabolic process (GO:0043170)	0.83	16	CRBN, PIGG, FBXO31, NDST1, TUSC3, PGAP1, HERC2, CC2D1A, ADAT3, PRSS12, MAN1B1, ST3GAL3, EDC3, NSUN2, MED23, TAF2
cellular macromolecule metabolic process (GO:0044260)	0.93	15	CRBN, ST3GAL3, FBXO31, NDST1, PGAP1, TUSC3, CC2D1A, ADAT3, HERC2, MAN1B1, PIGG, EDC3, NSUN2, MED23, TAF2
biological regulation (GO:0065007)	0.39	13	CRBN, HNMT, FBXO31, HERC2, MED23, NDST1, CC2D1A, GRIK2, FMN2, ANK3, CRADD, TRAPPC9, TAF2
nitrogen compound metabolic process (GO:0006807)	1.13	12	CC2D1A, HNMT, GPT2, HERC2, MED23, NDST1, ADAT3, EDC3, ST3GAL3, NSUN2, PGAP1, TAF2
regulation of biological process (GO:0050789)	0.45	12	CRBN, HNMT, FBXO31, MED23, NDST1, CC2D1A, GRIK2, FMN2, ANK3, CRADD, TRAPPC9, TAF2
regulation of cellular process (GO:0050794)	0.5	12	CRBN, HNMT, FBXO31, MED23, NDST1, CC2D1A, GRIK2, FMN2, ANK3, CRADD, TRAPPC9, TAF2
protein metabolic process (GO:0019538)	1.45	11	CRBN, PIGG, FBXO31, TUSC3, PGAP1, NDST1, PRSS12, HERC2, MAN1B1, ST3GAL3, TAF2
macromolecule modification (GO:0043412)	1.73	11	CRBN, ST3GAL3, FBXO31, TUSC3, PGAP1, NDST1, ADAT3, HERC2, PIGG, NSUN2, MAN1B1
establishment of localization (GO:0051234)	1.48	10	KIAA1033, HERC2, PGAP1, TUSC3, FMN2, GRIK2, PRSS12, SLC6A17, ANK3, LMAN2L
localization (GO:0051179)	1.4	10	KIAA1033, HERC2, PGAP1, TUSC3, FMN2, GRIK2, PRSS12, SLC6A17, ANK3, LMAN2L
transport (GO:0006810)	1.51	10	KIAA1033, HERC2, PGAP1, TUSC3, FMN2, GRIK2, PRSS12, SLC6A17, ANK3, LMAN2L
cellular protein metabolic process (GO:0044267)	1.63	9	CRBN, ST3GAL3, FBXO31, NDST1, HERC2, PGAP1, TUSC3, PIGG, MAN1B1
single-organism metabolic process (GO:0044710)	1.63	9	ST3GAL3, GPT2, TUSC3, PGAP1, NDST1, HNMT, TECR, PIGG, MAN1B1
organic substance biosynthetic process (GO:1901576)	1.34	9	CC2D1A, ST3GAL3, GPT2, MED23, NDST1, TECR, PIGG, PGAP1, TAF2
response to stimulus (GO:0050896)	1.22	9	HNMT, FBXO31, NDST1, HERC2, GRIK2, FMN2, ANK3, CRADD, TAF2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	9	CC2D1A, MED23, HERC2, ADAT3, EDC3, ST3GAL3, NSUN2, PGAP1, TAF2
cellular protein modification process (GO:0006464)	1.79	9	CRBN, ST3GAL3, FBXO31, NDST1, HERC2, PGAP1, TUSC3, PIGG, MAN1B1
cellular biosynthetic process (GO:0044249)	1.37	9	CC2D1A, ST3GAL3, GPT2, MED23, NDST1, TECR, PIGG, PGAP1, TAF2
biosynthetic process (GO:0009058)	1.32	9	CC2D1A, PIGG, GPT2, MED23, NDST1, TECR, ST3GAL3, PGAP1, TAF2
protein modification process (GO:0036211)	1.79	9	CRBN, ST3GAL3, FBXO31, NDST1, HERC2, PGAP1, TUSC3, PIGG, MAN1B1
cellular component organization (GO:0016043)	1.24	9	KIAA1033, KPTN, TRAPPC9, GRIK2, FMN2, TAF2, ANK3, NSUN2, EDC3
positive regulation of biological process (GO:0048518)	1.2	9	CC2D1A, HNMT, FBXO31, TRAPPC9, GRIK2, FMN2, ANK3, CRADD, TAF2
cellular component organization or biogenesis (GO:0071840)	1.22	9	KIAA1033, KPTN, TRAPPC9, GRIK2, FMN2, TAF2, ANK3, NSUN2, EDC3
developmental process (GO:0032502)	1.36	8	HNMT, TRAPPC9, NDST1, SLC6A17, FMN2, ANK3, NSUN2, PGAP1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	8	CC2D1A, PGAP1, HERC2, ADAT3, TAF2, NSUN2, MED23, EDC3
nucleic acid metabolic process (GO:0090304)	1.46	8	CC2D1A, PGAP1, HERC2, ADAT3, TAF2, NSUN2, MED23, EDC3
multicellular organismal process (GO:0032501)	1.45	8	KPTN, TUSC3, PGAP1, NDST1, GRIK2, FMN2, HNMT, LINS1
regulation of metabolic process (GO:0019222)	1.02	8	CC2D1A, TRAPPC9, GRIK2, FMN2, ANK3, CRADD, MED23, TAF2
regulation of macromolecule metabolic process (GO:0060255)	1.08	8	CC2D1A, TRAPPC9, GRIK2, FMN2, ANK3, CRADD, MED23, TAF2
cellular aromatic compound metabolic process (GO:0006725)	1.3	8	CC2D1A, PGAP1, HERC2, ADAT3, TAF2, NSUN2, MED23, EDC3
single-organism developmental process (GO:0044767)	1.49	8	HNMT, PGAP1, NDST1, SLC6A17, FMN2, ANK3, NSUN2, TRAPPC9
organic substance transport (GO:0071702)	2.15	8	KIAA1033, PGAP1, HERC2, GRIK2, FMN2, SLC6A17, ANK3, LMAN2L
heterocycle metabolic process (GO:0046483)	1.31	8	CC2D1A, PGAP1, HERC2, ADAT3, TAF2, NSUN2, MED23, EDC3
organic cyclic compound metabolic process (GO:1901360)	1.26	8	CC2D1A, PGAP1, HERC2, ADAT3, TAF2, NSUN2, MED23, EDC3
positive regulation of cellular process (GO:0048522)	1.3	8	CC2D1A, HNMT, FBXO31, GRIK2, FMN2, ANK3, CRADD, TAF2
protein localization (GO:0008104)	2.36	7	KIAA1033, PGAP1, HERC2, GRIK2, FMN2, ANK3, LMAN2L
regulation of primary metabolic process (GO:0080090)	1.08	7	CC2D1A, MED23, GRIK2, FMN2, CRADD, TRAPPC9, TAF2
anatomical structure development (GO:0048856)	1.58	7	TRAPPC9, NDST1, SLC6A17, FMN2, HNMT, NSUN2, PGAP1
establishment of protein localization (GO:0045184)	2.53	7	KIAA1033, PGAP1, HERC2, GRIK2, FMN2, ANK3, LMAN2L
response to stress (GO:0006950)	1.8	7	FBXO31, NDST1, HERC2, GRIK2, FMN2, HNMT, CRADD
protein transport (GO:0015031)	2.62	7	KIAA1033, PGAP1, HERC2, GRIK2, FMN2, ANK3, LMAN2L
negative regulation of biological process (GO:0048519)	1.33	7	CRBN, FBXO31, CC2D1A, GRIK2, FMN2, ANK3, CRADD
macromolecule localization (GO:0033036)	2.34	7	KIAA1033, PGAP1, HERC2, GRIK2, FMN2, ANK3, LMAN2L
negative regulation of cellular process (GO:0048523)	1.41	7	CRBN, FBXO31, CC2D1A, GRIK2, FMN2, ANK3, CRADD
RNA metabolic process (GO:0016070)	1.59	6	CC2D1A, MED23, ADAT3, TAF2, NSUN2, EDC3
organelle organization (GO:0006996)	2.02	6	KIAA1033, TRAPPC9, FMN2, ANK3, NSUN2, EDC3
organic substance catabolic process (GO:1901575)	2.45	6	CRBN, GPT2, FBXO31, MAN1B1, HNMT, EDC3
single-organism biosynthetic process (GO:0044711)	2.8	6	ST3GAL3, GPT2, PGAP1, NDST1, TECR, PIGG
regulation of cellular metabolic process (GO:0031323)	1.07	6	CC2D1A, TRAPPC9, GRIK2, CRADD, MED23, TAF2
cellular catabolic process (GO:0044248)	2.62	6	CRBN, GPT2, FBXO31, MAN1B1, HNMT, EDC3
cell cycle process (GO:0022402)	2.75	6	FBXO31, NSUN2, FMN2, ANK3, CRADD, TAF2
signal transduction (GO:0007165)	1.28	6	CC2D1A, NDST1, GRIK2, FMN2, ANK3, CRADD
catabolic process (GO:0009056)	2.38	6	CRBN, GPT2, FBXO31, MAN1B1, HNMT, EDC3
single-organism localization (GO:1902578)	2.09	6	PGAP1, PRSS12, GRIK2, FMN2, SLC6A17, ANK3
cellular response to stimulus (GO:0051716)	1.97	5	CRADD, FMN2, HERC2, FBXO31, ANK3
cellular component assembly (GO:0022607)	2.14	5	FMN2, TRAPPC9, ANK3, EDC3, TAF2
single-multicellular organism process (GO:0044707)	1.78	5	FMN2, PGAP1, NDST1, HNMT, GRIK2
intracellular transport (GO:0046907)	2.67	5	LMAN2L, FMN2, HERC2, GRIK2, ANK3
mitotic cell cycle process (GO:1903047)	3.12	5	FBXO31, CRADD, NSUN2, TAF2, ANK3
regulation of cellular component organization (GO:0051128)	2.01	5	FBXO31, CRBN, HNMT, FMN2, ANK3
macromolecule biosynthetic process (GO:0009059)	1.61	5	MED23, NDST1, CC2D1A, ST3GAL3, TAF2
positive regulation of molecular function (GO:0044093)	2.23	5	CRADD, TRAPPC9, HERC2, CRBN, ANK3
establishment of localization in cell (GO:0051649)	2.47	5	ANK3, FMN2, HERC2, GRIK2, LMAN2L
proteolysis (GO:0006508)	2.73	5	FBXO31, CRBN, PRSS12, MAN1B1, TAF2
regulation of molecular function (GO:0065009)	1.78	5	HERC2, TRAPPC9, CRADD, CRBN, ANK3
regulation of cell communication (GO:0010646)	1.73	5	CC2D1A, CRADD, ANK3, GRIK2, TAF2
regulation of gene expression (GO:0010468)	1.37	5	TRAPPC9, TAF2, MED23, ANK3, CC2D1A
cellular localization (GO:0051641)	2.32	5	LMAN2L, FMN2, HERC2, ANK3, GRIK2
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	TRAPPC9, MED23, TAF2, CC2D1A
regulation of response to stimulus (GO:0048583)	1.54	4	CC2D1A, CRADD, TAF2, GRIK2
cellular macromolecule biosynthetic process (GO:0034645)	1.66	4	MED23, NDST1, CC2D1A, TAF2
regulation of signaling (GO:0023051)	1.72	4	CC2D1A, CRADD, TAF2, GRIK2
positive regulation of cell communication (GO:0010647)	2.41	4	CC2D1A, CRADD, ANK3, GRIK2
carbohydrate metabolic process (GO:0005975)	3.26	4	TUSC3, NDST1, MAN1B1, ST3GAL3
cellular macromolecule catabolic process (GO:0044265)	3.19	4	FBXO31, CRBN, EDC3, MAN1B1
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	4	MED23, CC2D1A, ST3GAL3, TAF2
regulation of signal transduction (GO:0009966)	1.84	4	CC2D1A, CRADD, TAF2, GRIK2
cellular developmental process (GO:0048869)	1.82	4	TRAPPC9, NSUN2, FMN2, ANK3
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	TRAPPC9, MED23, TAF2, CC2D1A
lipid biosynthetic process (GO:0008610)	3.49	4	PIGG, PGAP1, TECR, ST3GAL3
positive regulation of cellular component organization (GO:0051130)	2.68	4	FMN2, HNMT, FBXO31, ANK3
lipid metabolic process (GO:0006629)	2.68	4	PIGG, PGAP1, TECR, ST3GAL3
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	TRAPPC9, MED23, TAF2, CC2D1A
neurological system process (GO:0050877)	2.64	4	PGAP1, TUSC3, LINS1, KPTN
regulation of biosynthetic process (GO:0009889)	1.37	4	TRAPPC9, MED23, TAF2, CC2D1A
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	TRAPPC9, MED23, TAF2, CC2D1A
cellular response to DNA damage stimulus (GO:0006974)	3.17	4	CRADD, FMN2, HERC2, FBXO31
single-organism transport (GO:0044765)	2.18	4	ANK3, PGAP1, PRSS12, SLC6A17
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	TRAPPC9, MED23, TAF2, CC2D1A
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	TRAPPC9, MED23, TAF2, CC2D1A
single-organism carbohydrate metabolic process (GO:0044723)	3.42	4	NDST1, TUSC3, ST3GAL3, MAN1B1
response to chemical (GO:0042221)	1.98	4	FMN2, ANK3, HNMT, TAF2
cellular lipid metabolic process (GO:0044255)	2.92	4	PIGG, PGAP1, TECR, ST3GAL3
regulation of localization (GO:0032879)	1.94	4	FBXO31, CRBN, HNMT, ANK3
macromolecule catabolic process (GO:0009057)	3.0	4	FBXO31, CRBN, EDC3, MAN1B1
system process (GO:0003008)	2.3	4	PGAP1, TUSC3, LINS1, KPTN
organonitrogen compound metabolic process (GO:1901564)	2.32	4	GPT2, NDST1, HNMT, ST3GAL3
vesicle-mediated transport (GO:0016192)	2.72	4	ANK3, FMN2, PRSS12, LMAN2L
carbohydrate derivative biosynthetic process (GO:1901137)	3.73	4	PGAP1, NDST1, PIGG, ST3GAL3
carbohydrate derivative metabolic process (GO:1901135)	3.07	4	PGAP1, NDST1, PIGG, ST3GAL3
regulation of RNA metabolic process (GO:0051252)	1.52	4	TRAPPC9, MED23, TAF2, CC2D1A
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	TRAPPC9, MED23, TAF2, CC2D1A
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	TRAPPC9, MED23, TAF2, CC2D1A
cellular response to stress (GO:0033554)	2.51	4	HERC2, FMN2, CRADD, FBXO31
positive regulation of metabolic process (GO:0009893)	1.74	3	CRADD, TAF2, ANK3
macromolecular complex subunit organization (GO:0043933)	2.14	3	TRAPPC9, TAF2, EDC3
regulation of transport (GO:0051049)	2.24	3	CRBN, ANK3, HNMT
carboxylic acid metabolic process (GO:0019752)	3.12	3	TECR, GPT2, HNMT
movement of cell or subcellular component (GO:0006928)	2.61	3	FMN2, KPTN, ANK3
positive regulation of signaling (GO:0023056)	2.41	3	CC2D1A, CRADD, GRIK2
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	3	MED23, CC2D1A, TAF2
small molecule metabolic process (GO:0044281)	2.38	3	TECR, GPT2, HNMT
cell surface receptor signaling pathway (GO:0007166)	2.09	3	CRADD, NDST1, GRIK2
glycolipid biosynthetic process (GO:0009247)	5.6	3	PGAP1, PIGG, ST3GAL3
intracellular signal transduction (GO:0035556)	2.39	3	CRADD, FMN2, NDST1
regulation of cell death (GO:0010941)	2.43	3	FMN2, CRADD, GRIK2
organic cyclic compound biosynthetic process (GO:1901362)	1.66	3	MED23, CC2D1A, TAF2
modification-dependent macromolecule catabolic process (GO:0043632)	3.69	3	CRBN, FBXO31, MAN1B1
nucleic acid-templated transcription (GO:0097659)	1.91	3	MED23, CC2D1A, TAF2
RNA biosynthetic process (GO:0032774)	1.84	3	MED23, CC2D1A, TAF2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	CRADD, TAF2, ANK3
protein glycosylation (GO:0006486)	4.2	3	TUSC3, ST3GAL3, MAN1B1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	3	MED23, CC2D1A, TAF2
regulation of apoptotic process (GO:0042981)	2.5	3	FMN2, CRADD, GRIK2
intracellular protein transport (GO:0006886)	3.2	3	HERC2, ANK3, GRIK2
regulation of protein metabolic process (GO:0051246)	1.93	3	FMN2, CRADD, GRIK2
peptidyl-amino acid modification (GO:0018193)	2.98	3	TUSC3, HERC2, ST3GAL3
macromolecular complex assembly (GO:0065003)	2.55	3	TRAPPC9, TAF2, EDC3
protein modification by small protein conjugation (GO:0032446)	3.1	3	CRBN, HERC2, FBXO31
regulation of programmed cell death (GO:0043067)	2.49	3	FMN2, CRADD, GRIK2
animal organ development (GO:0048513)	2.53	3	NDST1, HNMT, SLC6A17
organic acid metabolic process (GO:0006082)	3.01	3	TECR, GPT2, HNMT
membrane lipid biosynthetic process (GO:0046467)	4.99	3	PGAP1, PIGG, ST3GAL3
methylation (GO:0032259)	4.06	3	NSUN2, HNMT, METTL23
glycolipid metabolic process (GO:0006664)	5.01	3	PGAP1, PIGG, ST3GAL3
heterocycle biosynthetic process (GO:0018130)	1.7	3	MED23, CC2D1A, TAF2
liposaccharide metabolic process (GO:1903509)	4.98	3	PGAP1, PIGG, ST3GAL3
membrane lipid metabolic process (GO:0006643)	4.51	3	PGAP1, PIGG, ST3GAL3
response to abiotic stimulus (GO:0009628)	2.8	3	FMN2, CRADD, HNMT
glycosylation (GO:0070085)	4.16	3	TUSC3, MAN1B1, ST3GAL3
ion transport (GO:0006811)	2.66	3	TUSC3, SLC6A17, GRIK2
modification-dependent protein catabolic process (GO:0019941)	3.71	3	CRBN, FBXO31, MAN1B1
reproductive process (GO:0022414)	2.55	3	NSUN2, FMN2, HERC2
macromolecule glycosylation (GO:0043413)	4.2	3	TUSC3, MAN1B1, ST3GAL3
protein catabolic process (GO:0030163)	3.93	3	CRBN, FBXO31, MAN1B1
oxoacid metabolic process (GO:0043436)	3.12	3	TECR, GPT2, HNMT
regulation of intracellular signal transduction (GO:1902531)	2.31	3	CC2D1A, TAF2, GRIK2
transmembrane transport (GO:0055085)	2.72	3	TUSC3, SLC6A17, GRIK2
protein modification by small protein conjugation or removal (GO:0070647)	2.95	3	CRBN, HERC2, FBXO31
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	3	CRBN, FBXO31, MAN1B1
single organism reproductive process (GO:0044702)	2.73	3	HERC2, FMN2, NSUN2
regulation of biological quality (GO:0065008)	1.68	3	FMN2, ANK3, GRIK2
organonitrogen compound biosynthetic process (GO:1901566)	2.85	3	NDST1, GPT2, ST3GAL3
sulfur compound biosynthetic process (GO:0044272)	4.5	3	TECR, NDST1, ST3GAL3
proteasomal protein catabolic process (GO:0010498)	4.12	3	CRBN, FBXO31, MAN1B1
protein ubiquitination (GO:0016567)	3.28	3	CRBN, HERC2, FBXO31
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	PGAP1, NDST1, PIGG
ubiquitin-dependent protein catabolic process (GO:0006511)	3.72	3	CRBN, FBXO31, MAN1B1
sulfur compound metabolic process (GO:0006790)	3.87	3	TECR, NDST1, ST3GAL3
transcription, DNA-templated (GO:0006351)	1.91	3	MED23, CC2D1A, TAF2
phosphorus metabolic process (GO:0006793)	2.15	3	PGAP1, NDST1, PIGG
aromatic compound biosynthetic process (GO:0019438)	1.7	3	MED23, CC2D1A, TAF2
single-organism cellular localization (GO:1902580)	3.16	3	FMN2, ANK3, GRIK2
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)	4.16	3	CRBN, FBXO31, MAN1B1
regulation of intracellular protein transport (GO:0033157)	3.8	2	HNMT, ANK3
positive regulation of intracellular transport (GO:0032388)	4.08	2	HNMT, ANK3
regulation of intracellular transport (GO:0032386)	3.58	2	HNMT, ANK3
positive regulation of response to stimulus (GO:0048584)	2.18	2	CC2D1A, CRADD
cell development (GO:0048468)	3.28	2	FMN2, NSUN2
RNA modification (GO:0009451)	4.94	2	NSUN2, ADAT3
membrane organization (GO:0061024)	3.04	2	ANK3, GRIK2
small molecule catabolic process (GO:0044282)	3.99	2	GPT2, HNMT
small molecule biosynthetic process (GO:0044283)	3.79	2	TECR, GPT2
inorganic ion homeostasis (GO:0098771)	3.43	2	ANK3, GRIK2
regulation of ion transmembrane transport (GO:0034765)	3.77	2	CRBN, ANK3
negative regulation of ion transmembrane transport (GO:0034766)	5.47	2	CRBN, ANK3
regulation of transmembrane transport (GO:0034762)	3.74	2	CRBN, ANK3
negative regulation of transmembrane transport (GO:0034763)	5.38	2	CRBN, ANK3
single-organism catabolic process (GO:0044712)	3.21	2	GPT2, HNMT
negative regulation of cell cycle (GO:0045786)	3.67	2	CRADD, FBXO31
cellular macromolecule localization (GO:0070727)	3.1	2	ANK3, GRIK2
positive regulation of signal transduction (GO:0009967)	2.5	2	CC2D1A, CRADD
peptidyl-asparagine modification (GO:0018196)	6.07	2	TUSC3, ST3GAL3
phosphatidylinositol biosynthetic process (GO:0006661)	4.94	2	PGAP1, PIGG
ncRNA processing (GO:0034470)	3.77	2	NSUN2, ADAT3
negative regulation of transport (GO:0051051)	3.6	2	CRBN, ANK3
positive regulation of transport (GO:0051050)	2.9	2	HNMT, ANK3
sensory perception of sound (GO:0007605)	4.82	2	PGAP1, KPTN
negative regulation of cell death (GO:0060548)	2.95	2	FMN2, GRIK2
sensory perception (GO:0007600)	2.93	2	PGAP1, KPTN
germ cell development (GO:0007281)	4.75	2	FMN2, NSUN2
developmental process involved in reproduction (GO:0003006)	3.36	2	FMN2, NSUN2
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	PGAP1, PIGG
protein localization to membrane (GO:0072657)	3.95	2	ANK3, GRIK2
glycerolipid metabolic process (GO:0046486)	3.91	2	PGAP1, PIGG
response to organic substance (GO:0010033)	2.2	2	TAF2, HNMT
cytokinesis (GO:0000910)	5.22	2	FMN2, ANK3
organonitrogen compound catabolic process (GO:1901565)	3.91	2	GPT2, HNMT
organic acid catabolic process (GO:0016054)	4.44	2	GPT2, HNMT
positive regulation of organelle organization (GO:0010638)	3.38	2	FMN2, HNMT
organic acid biosynthetic process (GO:0016053)	4.26	2	TECR, GPT2
protein N-linked glycosylation via asparagine (GO:0018279)	6.09	2	TUSC3, ST3GAL3
organophosphate metabolic process (GO:0019637)	3.04	2	PGAP1, PIGG
chemical homeostasis (GO:0048878)	2.97	2	ANK3, GRIK2
regulation of membrane potential (GO:0042391)	3.89	2	ANK3, GRIK2
negative regulation of metabolic process (GO:0009892)	1.93	2	CC2D1A, FMN2
regulation of protein targeting (GO:1903533)	4.0	2	HNMT, ANK3
neuronal action potential (GO:0019228)	6.4	2	ANK3, GRIK2
cellular amino acid catabolic process (GO:0009063)	5.37	2	GPT2, HNMT
action potential (GO:0001508)	5.42	2	ANK3, GRIK2
positive regulation of gene expression (GO:0010628)	2.35	2	TAF2, ANK3
cytoskeleton-dependent cytokinesis (GO:0061640)	6.2	2	FMN2, ANK3
ncRNA metabolic process (GO:0034660)	3.44	2	NSUN2, ADAT3
positive regulation of protein transport (GO:0051222)	3.61	2	HNMT, ANK3
regulation of protein transport (GO:0051223)	3.12	2	HNMT, ANK3
regulation of mitotic cell cycle (GO:0007346)	3.71	2	CRADD, FBXO31
anatomical structure morphogenesis (GO:0009653)	2.53	2	NDST1, ANK3
ER to Golgi vesicle-mediated transport (GO:0006888)	4.7	2	LMAN2L, ANK3
positive regulation of hydrolase activity (GO:0051345)	2.91	2	CRADD, HERC2
positive regulation of cellular protein localization (GO:1903829)	3.85	2	HNMT, ANK3
transcription initiation from RNA polymerase II promoter (GO:0006367)	4.7	2	MED23, TAF2
regulation of establishment of protein localization (GO:0070201)	3.02	2	HNMT, ANK3
respiratory gaseous exchange (GO:0007585)	5.86	2	NDST1, HNMT
sensory perception of mechanical stimulus (GO:0050954)	4.79	2	PGAP1, KPTN
regulation of catalytic activity (GO:0050790)	1.97	2	CRADD, HERC2
regulation of cellular component biogenesis (GO:0044087)	3.08	2	CRBN, FMN2
defense response (GO:0006952)	2.78	2	NDST1, GRIK2
programmed cell death (GO:0012501)	3.1	2	CRADD, GRIK2
single-organism membrane organization (GO:0044802)	3.19	2	ANK3, GRIK2
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	5.17	2	CRADD, FBXO31
regulation of protein complex assembly (GO:0043254)	3.83	2	CRBN, FMN2
organophosphate biosynthetic process (GO:0090407)	3.67	2	PGAP1, PIGG
negative regulation of cell cycle phase transition (GO:1901988)	4.74	2	CRADD, FBXO31
regulation of hydrolase activity (GO:0051336)	2.53	2	CRADD, HERC2
brain development (GO:0007420)	4.24	2	HNMT, SLC6A17
phospholipid biosynthetic process (GO:0008654)	4.39	2	PGAP1, PIGG
carboxylic acid biosynthetic process (GO:0046394)	4.32	2	TECR, GPT2
carboxylic acid catabolic process (GO:0046395)	4.58	2	GPT2, HNMT
cognition (GO:0050890)	4.2	2	TUSC3, LINS1
DNA-templated transcription, initiation (GO:0006352)	4.49	2	MED23, TAF2
aminoglycan metabolic process (GO:0006022)	4.62	2	NDST1, ST3GAL3
aminoglycan biosynthetic process (GO:0006023)	5.06	2	NDST1, ST3GAL3
glycosaminoglycan biosynthetic process (GO:0006024)	5.07	2	NDST1, ST3GAL3
positive regulation of catalytic activity (GO:0043085)	2.4	2	CRADD, HERC2
regulation of organelle organization (GO:0033043)	2.72	2	FMN2, HNMT
ion homeostasis (GO:0050801)	3.42	2	ANK3, GRIK2
metal ion homeostasis (GO:0055065)	3.61	2	ANK3, GRIK2
oligosaccharide metabolic process (GO:0009311)	5.54	2	MAN1B1, ST3GAL3
regulation of cellular protein localization (GO:1903827)	3.43	2	HNMT, ANK3
negative regulation of mitotic cell cycle phase transition (GO:1901991)	4.82	2	CRADD, FBXO31
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	2	CRADD, FBXO31
cellular response to chemical stimulus (GO:0070887)	2.57	2	FMN2, ANK3
glycosaminoglycan metabolic process (GO:0030203)	4.67	2	NDST1, ST3GAL3
positive regulation of establishment of protein localization (GO:1904951)	3.49	2	HNMT, ANK3
response to organic cyclic compound (GO:0014070)	3.07	2	HNMT, TAF2
regulation of protein localization (GO:0032880)	2.88	2	HNMT, ANK3
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	ANK3, GRIK2
regulation of cell cycle process (GO:0010564)	3.5	2	CRADD, FBXO31
GPI anchor metabolic process (GO:0006505)	6.23	2	PGAP1, PIGG
GPI anchor biosynthetic process (GO:0006506)	6.26	2	PGAP1, PIGG
regulation of cell cycle phase transition (GO:1901987)	4.15	2	CRADD, FBXO31
apoptotic process (GO:0006915)	3.14	2	CRADD, GRIK2
phospholipid metabolic process (GO:0006644)	3.88	2	PGAP1, PIGG
tRNA processing (GO:0008033)	4.96	2	NSUN2, ADAT3
multicellular organismal reproductive process (GO:0048609)	3.35	2	FMN2, HERC2
negative regulation of ion transport (GO:0043271)	4.94	2	CRBN, ANK3
cation homeostasis (GO:0055080)	3.46	2	ANK3, GRIK2
meiotic cell cycle process (GO:1903046)	4.71	2	FMN2, NSUN2
cell cycle (GO:0007049)	3.14	2	NSUN2, FBXO31
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	CRADD, GRIK2
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	2	CRADD, FBXO31
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	CC2D1A, FMN2
glycerophospholipid biosynthetic process (GO:0046474)	4.62	2	PGAP1, PIGG
negative regulation of cell cycle G1/S phase transition (GO:1902807)	5.14	2	CRADD, FBXO31
glycerophospholipid metabolic process (GO:0006650)	4.13	2	PGAP1, PIGG
regulation of cellular localization (GO:0060341)	3.03	2	HNMT, ANK3
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	CRADD, TAF2
mucopolysaccharide metabolic process (GO:1903510)	5.05	2	NDST1, ST3GAL3
homeostatic process (GO:0042592)	2.61	2	ANK3, GRIK2
nucleic acid phosphodiester bond hydrolysis (GO:0090305)	4.12	2	PGAP1, EDC3
negative regulation of cell cycle process (GO:0010948)	4.37	2	CRADD, FBXO31
cellular macromolecular complex assembly (GO:0034622)	3.18	2	TAF2, EDC3
positive regulation of cell death (GO:0010942)	3.32	2	CRADD, GRIK2
cell death (GO:0008219)	3.05	2	CRADD, GRIK2
gamete generation (GO:0007276)	3.61	2	FMN2, HERC2
glycerolipid biosynthetic process (GO:0045017)	4.53	2	PGAP1, PIGG
protein N-linked glycosylation (GO:0006487)	5.65	2	TUSC3, ST3GAL3
cellular amino acid metabolic process (GO:0006520)	4.22	2	GPT2, HNMT
positive regulation of apoptotic process (GO:0043065)	3.38	2	CRADD, GRIK2
negative regulation of apoptotic process (GO:0043066)	3.04	2	FMN2, GRIK2
regulation of ion transport (GO:0043269)	3.4	2	CRBN, ANK3
tRNA modification (GO:0006400)	5.59	2	NSUN2, ADAT3
negative regulation of programmed cell death (GO:0043069)	3.02	2	FMN2, GRIK2
positive regulation of programmed cell death (GO:0043068)	3.38	2	CRADD, GRIK2
negative regulation of mitotic cell cycle (GO:0045930)	4.45	2	CRADD, FBXO31
Golgi vesicle transport (GO:0048193)	4.07	2	LMAN2L, ANK3
cellular protein localization (GO:0034613)	3.11	2	ANK3, GRIK2
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	HNMT, ANK3
cellular process involved in reproduction in multicellular organism (GO:0022412)	4.3	2	FMN2, NSUN2
protein lipidation (GO:0006497)	5.38	2	PGAP1, PIGG
actin filament organization (GO:0007015)	4.54	2	FMN2, KPTN
cytoskeleton organization (GO:0007010)	3.22	2	FMN2, ANK3
cell cycle checkpoint (GO:0000075)	4.79	2	NSUN2, FBXO31
regulation of cell cycle (GO:0051726)	2.93	2	CRADD, FBXO31
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	2	CRADD, FBXO31
tRNA metabolic process (GO:0006399)	4.52	2	NSUN2, ADAT3
single-organism organelle organization (GO:1902589)	2.68	2	FMN2, ANK3
RNA processing (GO:0006396)	3.01	2	NSUN2, ADAT3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
post-translational protein modification (GO:0043687)	NEW	6.17	0.013	PIGG, PGAP1, TUSC3, MAN1B1, ST3GAL3

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	29	KPTN, GPT2, TRAPPC9, TUSC3, GRIK2, HNMT, NSUN2, CC2D1A, METTL23, PGAP1, NDST1, PRSS12, ST3GAL3, ANK3, CRADD, MAN1B1, TAF2, FBXO31, MED23, HERC2, CRBN, ADAT3, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, EDC3
cell part (GO:0044464)	0.11	29	KPTN, GPT2, TRAPPC9, TUSC3, GRIK2, HNMT, NSUN2, CC2D1A, METTL23, PGAP1, NDST1, PRSS12, ST3GAL3, ANK3, CRADD, MAN1B1, TAF2, FBXO31, MED23, HERC2, CRBN, ADAT3, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, EDC3
organelle (GO:0043226)	0.4	27	KPTN, GPT2, TRAPPC9, TUSC3, GRIK2, HNMT, NSUN2, CC2D1A, PGAP1, NDST1, PRSS12, ST3GAL3, ANK3, CRADD, MAN1B1, TAF2, FBXO31, MED23, HERC2, CRBN, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, EDC3
intracellular organelle (GO:0043229)	0.51	25	KPTN, GPT2, TRAPPC9, TUSC3, SLC6A17, ANK3, NSUN2, CC2D1A, PGAP1, NDST1, ST3GAL3, CRADD, MAN1B1, TAF2, FBXO31, MED23, HERC2, CRBN, FMN2, PIGG, LMAN2L, KIAA1033, TECR, GRIK2, EDC3
cytoplasmic part (GO:0044444)	0.82	24	KPTN, GPT2, TRAPPC9, TUSC3, SLC6A17, HNMT, NSUN2, PGAP1, NDST1, PRSS12, ST3GAL3, ANK3, CRADD, MAN1B1, FBXO31, HERC2, ADAT3, TECR, PIGG, LMAN2L, KIAA1033, FMN2, GRIK2, EDC3
membrane-bounded organelle (GO:0043227)	0.47	24	KPTN, GPT2, TRAPPC9, TUSC3, HNMT, NSUN2, CC2D1A, PGAP1, NDST1, PRSS12, ST3GAL3, ANK3, CRADD, MAN1B1, MED23, HERC2, CRBN, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, TAF2
organelle part (GO:0044422)	0.79	24	KPTN, GPT2, TRAPPC9, TUSC3, HNMT, NSUN2, CC2D1A, PGAP1, NDST1, ST3GAL3, ANK3, MAN1B1, FBXO31, MED23, HERC2, CRBN, ADAT3, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, TAF2
intracellular organelle part (GO:0044446)	0.81	23	KPTN, GPT2, TRAPPC9, TUSC3, HNMT, NSUN2, CC2D1A, PGAP1, NDST1, ST3GAL3, MAN1B1, FBXO31, MED23, HERC2, CRBN, ADAT3, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, TAF2
intracellular membrane-bounded organelle (GO:0043231)	0.6	22	KPTN, GPT2, TRAPPC9, TUSC3, ANK3, NSUN2, CC2D1A, PGAP1, NDST1, ST3GAL3, CRADD, MAN1B1, MED23, HERC2, CRBN, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, TAF2
membrane (GO:0016020)	0.68	19	FMN2, CRBN, ST3GAL3, METTL23, NDST1, HERC2, TRAPPC9, TUSC3, TECR, GRIK2, CC2D1A, PRSS12, EDC3, PIGG, LMAN2L, SLC6A17, ANK3, PGAP1, MAN1B1
cytoplasm (GO:0005737)	1.01	14	FMN2, CRBN, HNMT, METTL23, CRADD, TRAPPC9, HERC2, CC2D1A, GRIK2, KPTN, TECR, ANK3, NSUN2, EDC3
membrane part (GO:0044425)	0.95	13	PIGG, METTL23, NDST1, PGAP1, TUSC3, FMN2, SLC6A17, TECR, GRIK2, ST3GAL3, LMAN2L, ANK3, MAN1B1
integral component of membrane (GO:0016021)	1.14	11	ST3GAL3, METTL23, NDST1, PGAP1, TUSC3, SLC6A17, TECR, GRIK2, PIGG, LMAN2L, MAN1B1
intrinsic component of membrane (GO:0031224)	1.13	11	ST3GAL3, METTL23, TUSC3, PGAP1, NDST1, GRIK2, TECR, SLC6A17, PIGG, LMAN2L, MAN1B1
nucleus (GO:0005634)	1.07	10	CRBN, CRADD, MED23, HERC2, TECR, CC2D1A, FMN2, KPTN, NSUN2, TAF2
non-membrane-bounded organelle (GO:0043228)	1.76	10	CRBN, KPTN, FBXO31, HERC2, CC2D1A, GRIK2, FMN2, ANK3, NSUN2, EDC3
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	10	CRBN, KPTN, FBXO31, HERC2, CC2D1A, GRIK2, FMN2, ANK3, NSUN2, EDC3
macromolecular complex (GO:0032991)	1.35	9	CRBN, FBXO31, MED23, TUSC3, KIAA1033, GRIK2, TAF2, NSUN2, EDC3
nuclear part (GO:0044428)	1.55	9	CRBN, MED23, HERC2, KIAA1033, ADAT3, FMN2, HNMT, NSUN2, TAF2
endoplasmic reticulum (GO:0005783)	2.56	9	ANK3, PGAP1, TUSC3, TECR, FMN2, LMAN2L, PIGG, TRAPPC9, MAN1B1
cytosol (GO:0005829)	1.68	8	HNMT, FBXO31, TRAPPC9, ADAT3, FMN2, ANK3, CRADD, EDC3
protein complex (GO:0043234)	1.51	7	KIAA1033, FBXO31, MED23, TUSC3, CRBN, GRIK2, TAF2
vesicle (GO:0031982)	1.64	7	CC2D1A, FMN2, SLC6A17, PRSS12, MAN1B1, HNMT, LMAN2L
neuron part (GO:0097458)	2.64	7	ANK3, FBXO31, SLC6A17, KPTN, PRSS12, GRIK2, HNMT
endoplasmic reticulum membrane (GO:0005789)	2.95	7	PGAP1, TUSC3, TECR, FMN2, LMAN2L, PIGG, MAN1B1
nucleoplasm (GO:0005654)	1.89	7	KIAA1033, MED23, HERC2, ADAT3, HNMT, NSUN2, TAF2
endoplasmic reticulum part (GO:0044432)	2.73	7	PGAP1, TUSC3, TECR, FMN2, LMAN2L, PIGG, MAN1B1
organelle membrane (GO:0031090)	1.97	7	NDST1, TRAPPC9, HERC2, SLC6A17, FMN2, ST3GAL3, LMAN2L
cytoskeleton (GO:0005856)	2.55	6	CC2D1A, ANK3, HERC2, FMN2, KPTN, NSUN2
Golgi apparatus (GO:0005794)	2.7	6	ST3GAL3, TRAPPC9, NDST1, MAN1B1, ANK3, LMAN2L
cell projection (GO:0042995)	2.47	6	ANK3, FMN2, HNMT, PRSS12, GRIK2, KPTN
cytoskeletal part (GO:0044430)	2.49	6	CC2D1A, FBXO31, HERC2, FMN2, KPTN, NSUN2
bounding membrane of organelle (GO:0098588)	2.39	5	TRAPPC9, ST3GAL3, NDST1, LMAN2L, SLC6A17
plasma membrane (GO:0005886)	1.39	5	FMN2, PRSS12, TUSC3, GRIK2, ANK3
neuron projection (GO:0043005)	3.12	4	ANK3, PRSS12, HNMT, GRIK2
catalytic complex (GO:1902494)	2.9	4	CRBN, TUSC3, TAF2, FBXO31
cytoplasmic vesicle (GO:0031410)	2.87	4	FMN2, PRSS12, SLC6A17, LMAN2L
cell projection part (GO:0044463)	2.97	4	KPTN, PRSS12, ANK3, GRIK2
Golgi membrane (GO:0000139)	3.28	4	TRAPPC9, NDST1, ST3GAL3, LMAN2L
Golgi apparatus part (GO:0044431)	3.0	4	TRAPPC9, NDST1, LMAN2L, ST3GAL3
synapse part (GO:0044456)	3.42	4	ANK3, PRSS12, SLC6A17, GRIK2
intracellular vesicle (GO:0097708)	2.86	4	FMN2, PRSS12, LMAN2L, SLC6A17
transferase complex (GO:1990234)	3.32	4	CRBN, TUSC3, TAF2, FBXO31
membrane-bounded vesicle (GO:0031988)	1.71	4	SLC6A17, CC2D1A, HNMT, LMAN2L
plasma membrane part (GO:0044459)	1.95	4	SLC6A17, TUSC3, ANK3, GRIK2
synapse (GO:0045202)	3.58	4	SLC6A17, PRSS12, ANK3, GRIK2
extracellular vesicle (GO:1903561)	1.89	3	CC2D1A, HNMT, MAN1B1
extracellular organelle (GO:0043230)	1.89	3	CC2D1A, HNMT, MAN1B1
nucleolus (GO:0005730)	3.06	3	CRBN, NSUN2, FMN2
dendrite (GO:0030425)	3.92	3	PRSS12, ANK3, GRIK2
axon (GO:0030424)	4.15	3	PRSS12, ANK3, GRIK2
integral component of plasma membrane (GO:0005887)	2.57	3	TUSC3, SLC6A17, GRIK2
axon part (GO:0033267)	4.4	3	PRSS12, ANK3, GRIK2
microtubule organizing center (GO:0005815)	3.42	3	CC2D1A, KPTN, FBXO31
intrinsic component of plasma membrane (GO:0031226)	2.53	3	TUSC3, SLC6A17, GRIK2
extracellular region part (GO:0044421)	1.57	3	CC2D1A, HNMT, MAN1B1
cell junction (GO:0030054)	2.75	3	SLC6A17, ANK3, GRIK2
plasma membrane region (GO:0098590)	2.97	2	ANK3, GRIK2
ribonucleoprotein granule (GO:0035770)	4.81	2	NSUN2, EDC3
actin cytoskeleton (GO:0015629)	4.39	2	FMN2, KPTN
integral component of endoplasmic reticulum membrane (GO:0030176)	5.01	2	TECR, PIGG
cytoplasmic ribonucleoprotein granule (GO:0036464)	4.87	2	NSUN2, EDC3
transport vesicle (GO:0030133)	4.3	2	SLC6A17, LMAN2L
intrinsic component of endoplasmic reticulum membrane (GO:0031227)	4.97	2	TECR, PIGG
synaptic membrane (GO:0097060)	4.22	2	ANK3, GRIK2
spindle (GO:0005819)	4.52	2	FMN2, NSUN2
extracellular exosome (GO:0070062)	1.89	2	CC2D1A, HNMT
membrane protein complex (GO:0098796)	2.84	2	TUSC3, GRIK2
vacuole (GO:0005773)	2.92	2	KIAA1033, ANK3
mitochondrion (GO:0005739)	2.42	2	TUSC3, GPT2
intracellular ribonucleoprotein complex (GO:0030529)	3.19	2	NSUN2, EDC3
cytoplasmic vesicle part (GO:0044433)	3.41	2	FMN2, SLC6A17
presynapse (GO:0098793)	4.97	2	PRSS12, GRIK2
perinuclear region of cytoplasm (GO:0048471)	3.35	2	FMN2, KPTN
neuronal cell body (GO:0043025)	3.9	2	FBXO31, GRIK2
cytoplasmic region (GO:0099568)	4.51	2	FMN2, GRIK2
cell body (GO:0044297)	3.74	2	FBXO31, GRIK2
cytoplasmic vesicle membrane (GO:0030659)	3.67	2	FMN2, SLC6A17
vesicle membrane (GO:0012506)	3.63	2	FMN2, SLC6A17
cullin-RING ubiquitin ligase complex (GO:0031461)	4.79	2	CRBN, FBXO31
terminal bouton (GO:0043195)	5.63	2	PRSS12, GRIK2
postsynaptic membrane (GO:0045211)	4.47	2	ANK3, GRIK2
ribonucleoprotein complex (GO:1990904)	3.19	2	NSUN2, EDC3
ubiquitin ligase complex (GO:0000151)	4.23	2	CRBN, FBXO31
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	LMAN2L, SLC6A17
extracellular region (GO:0005576)	2.18	2	PRSS12, ST3GAL3
actin-based cell projection (GO:0098858)	4.83	2	FMN2, KPTN
mitochondrial part (GO:0044429)	2.92	2	HERC2, GPT2
transcription factor complex (GO:0005667)	4.1	2	MED23, TAF2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
intracellular part (GO:0044424)	-	0.28	0.014	KPTN, GPT2, TRAPPC9, TUSC3, GRIK2, HNMT, NSUN2, CC2D1A, METTL23, PGAP1, NDST1, PRSS12, ST3GAL3, ANK3, CRADD, MAN1B1, TAF2, FBXO31, MED23, HERC2, CRBN, FMN2, PIGG, LMAN2L, KIAA1033, TECR, SLC6A17, EDC3
organelle part (GO:0044422)	-	0.79	0.039	CRBN, GRIK2, PIGG, GPT2, MAN1B1, NDST1, PGAP1, HERC2, FMN2, SLC6A17, CC2D1A, KPTN, TECR, TUSC3, LMAN2L, ST3GAL3, ANK3, NSUN2, MED23, TAF2
endoplasmic reticulum membrane (GO:0005789)	-	2.95	0.015	PGAP1, TUSC3, TECR, FMN2, LMAN2L, PIGG, MAN1B1