Disease table of USHER SYNDROME OMIM ID: PS276900

Gene-disease associations table

GeneAssociated with USHER SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PDZD7ClinVar, OMIMHGNC link10q24.311PS276900
USH2AClinVar, OMIM, HUMSAVARHGNC link1q412PS276900, PS268000
MYO7AClinVar, OMIM, HUMSAVARHGNC link11q13.54PS124900, PS220290, PS268000, PS276900
CDH23ClinVar, OMIM, HUMSAVARHGNC link10q22.12PS220290, PS276900
CIB2ClinVar, OMIM, HUMSAVARHGNC link15q25.12PS220290, PS276900
USH1CClinVar, OMIMHGNC link11p15.12PS220290, PS276900
WHRNClinVar, OMIMHGNC link9q322PS220290, PS276900
PCDH15ClinVar, OMIM, HUMSAVARHGNC link10q21.12PS220290, PS276900
ADGRV1ClinVar, OMIM, HUMSAVARHGNC link5q14.32PS121210, PS276900
HARSClinVar, OMIM, HUMSAVARHGNC link5q31.32PS118220, PS276900
USH1GClinVar, OMIM, HUMSAVARHGNC link17q25.11PS276900
CLRN1ClinVar, OMIM, HUMSAVARHGNC link3q25.12PS276900, PS268000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
10q23PDZD7, CDH23, PCDH15
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
5q2ADGRV1, HARS
10q3PDZD7, CDH23, PCDH15
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
112USH1C, MYO7A
103PDZD7, CDH23, PCDH15
52ADGRV1, HARS
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MYO7ACDH23No1USH1C
MYO7AUSH1CYes1USH1C
CDH23USH1CYes1USH1C
CDH23PCDH15No1DLG4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PDZD7USH2AYesbinding0
PDZD7USH1CNo-1USH2A
USH2ACDH23No-1USH1C
USH2AUSH1CYesbinding0
USH2APCDH15No-1USH1C
USH2AUSH1GNo-1USH1C
CDH23USH1CYesbinding1PCDH15
CDH23PCDH15Yesbinding1USH1C
CDH23USH1GNo-1USH1C
USH1CPCDH15Yesbinding1CDH23
USH1CUSH1GYesbinding0
PCDH15USH1GNo-1USH1C

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
CDH23USH1CYes2CDH23, USH1C
CDH23USH1GNo1USH1C
USH1CUSH1GYes2USH1G, USH1C

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189PDZD7, USH1G, CDH23, CIB2, PCDH15, HARS, MYO7A, USH1C, USH2A
protein binding (GO:0005515) 0.468PDZD7, USH1G, CDH23, CIB2, PCDH15, MYO7A, USH1C, USH2A
protein complex binding (GO:0032403) 3.095PCDH15, USH2A, USH1C, MYO7A, CIB2
protein dimerization activity (GO:0046983) 2.725PDZD7, USH2A, USH1G, MYO7A, CIB2
macromolecular complex binding (GO:0044877) 2.615PCDH15, USH2A, USH1C, MYO7A, CIB2
identical protein binding (GO:0042802) 2.635PDZD7, USH2A, USH1G, MYO7A, CIB2
protein homodimerization activity (GO:0042803) 3.165PDZD7, USH2A, USH1G, MYO7A, CIB2
cytoskeletal protein binding (GO:0008092) 3.024USH1G, USH1C, USH2A, MYO7A
metal ion binding (GO:0046872) 1.413PCDH15, CDH23, CIB2
cation binding (GO:0043169) 1.43PCDH15, CDH23, CIB2
ion binding (GO:0043167) 1.363PCDH15, CDH23, CIB2
calcium ion binding (GO:0005509) 3.173PCDH15, CDH23, CIB2
spectrin binding (GO:0030507) 6.483USH1G, USH1C, MYO7A
purine ribonucleoside triphosphate binding (GO:0035639) 2.222MYO7A, HARS
myosin binding (GO:0017022) 5.662USH1C, USH2A
heterocyclic compound binding (GO:1901363) 1.062HARS, MYO7A
nucleoside phosphate binding (GO:1901265) 1.962MYO7A, HARS
nucleoside binding (GO:0001882) 2.212MYO7A, HARS
nucleotide binding (GO:0000166) 1.962HARS, MYO7A
actin binding (GO:0003779) 3.742USH1C, MYO7A
purine nucleoside binding (GO:0001883) 2.222MYO7A, HARS
ribonucleoside binding (GO:0032549) 2.222MYO7A, HARS
purine nucleotide binding (GO:0017076) 2.192MYO7A, HARS
ATP binding (GO:0005524) 2.432HARS, MYO7A
actin filament binding (GO:0051015) 4.932USH1C, MYO7A
small molecule binding (GO:0036094) 1.892MYO7A, HARS
catalytic activity (GO:0003824) 1.052HARS, MYO7A
protein N-terminus binding (GO:0047485) 5.112PCDH15, MYO7A
adenyl nucleotide binding (GO:0030554) 2.42HARS, MYO7A
carbohydrate derivative binding (GO:0097367) 2.032MYO7A, HARS
organic cyclic compound binding (GO:0097159) 1.052MYO7A, HARS
adenyl ribonucleotide binding (GO:0032559) 2.412MYO7A, HARS
purine ribonucleotide binding (GO:0032555) 2.22MYO7A, HARS
purine ribonucleoside binding (GO:0032550) 2.222MYO7A, HARS
ribonucleotide binding (GO:0032553) 2.192HARS, MYO7A

NET-GE enrichment

Term New enriched termICP valueGenes
cytoskeletal protein binding (GO:0008092) -3.020.004MYO7A, USH1G, CDH23, PCDH15, USH2A, DFNB31, USH1C, ADGRV1
calcium ion binding (GO:0005509) -3.170.035CDH23, CIB2, PCDH15, USH2A, DFNB31, ADGRV1
myosin binding (GO:0017022) -5.660.013USH2A, ADGRV1, DFNB31
spectrin binding (GO:0030507) -6.480.0USH1G, USH1C, MYO7A
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2610PDZD7, USH1G, CDH23, CIB2, PCDH15, HARS, MYO7A, CLRN1, USH1C, USH2A
single-organism cellular process (GO:0044763) 0.6510PDZD7, USH1G, CDH23, CIB2, PCDH15, HARS, MYO7A, CLRN1, USH1C, USH2A
single-organism process (GO:0044699) 0.4810PDZD7, USH1G, CDH23, HARS, PCDH15, CIB2, MYO7A, CLRN1, USH1C, USH2A
multicellular organismal process (GO:0032501) 1.459PDZD7, USH1G, CDH23, CIB2, PCDH15, MYO7A, CLRN1, USH1C, USH2A
neurological system process (GO:0050877) 2.648PDZD7, USH1G, CDH23, PCDH15, MYO7A, CLRN1, USH1C, USH2A
cellular component organization (GO:0016043) 1.248PDZD7, USH1G, CDH23, HARS, PCDH15, MYO7A, CLRN1, USH1C
cellular component organization or biogenesis (GO:0071840) 1.228PDZD7, USH1G, CDH23, HARS, PCDH15, MYO7A, CLRN1, USH1C
system process (GO:0003008) 2.38PDZD7, USH1G, CDH23, PCDH15, MYO7A, CLRN1, USH1C, USH2A
single-multicellular organism process (GO:0044707) 1.787CDH23, USH1G, CIB2, PCDH15, CLRN1, USH1C, USH2A
sensory perception of sound (GO:0007605) 4.827CDH23, USH1G, PCDH15, MYO7A, CLRN1, USH1C, USH2A
sensory perception of mechanical stimulus (GO:0050954) 4.797CDH23, USH1G, PCDH15, MYO7A, CLRN1, USH1C, USH2A
sensory perception (GO:0007600) 2.937CDH23, USH1G, PCDH15, MYO7A, CLRN1, USH1C, USH2A
sensory perception of light stimulus (GO:0050953) 4.47CDH23, USH1G, PCDH15, MYO7A, CLRN1, USH1C, USH2A
photoreceptor cell maintenance (GO:0045494) 6.177CDH23, USH1G, CIB2, PCDH15, CLRN1, USH1C, USH2A
cellular developmental process (GO:0048869) 1.826PDZD7, USH1G, PCDH15, MYO7A, USH1C, USH2A
equilibrioception (GO:0050957) 7.946CDH23, USH1G, PCDH15, MYO7A, CLRN1, USH1C
response to stimulus (GO:0050896) 1.226PDZD7, CDH23, CIB2, PCDH15, CLRN1, USH2A
cell projection organization (GO:0030030) 3.145USH1G, PDZD7, CDH23, PCDH15, MYO7A
cell differentiation (GO:0030154) 2.145USH1G, PCDH15, USH1C, USH2A, MYO7A
visual perception (GO:0007601) 4.415CLRN1, PCDH15, CDH23, USH2A, MYO7A
inner ear receptor stereocilium organization (GO:0060122) 6.475USH1G, PDZD7, CDH23, PCDH15, MYO7A
biological regulation (GO:0065007) 0.395CDH23, USH1C, USH2A, CIB2, CLRN1
localization (GO:0051179) 1.45CDH23, PDZD7, USH1C, USH2A, MYO7A
developmental process (GO:0032502) 1.364PDZD7, USH1G, PCDH15, MYO7A
neuron differentiation (GO:0030182) 4.174PCDH15, USH1G, USH2A, MYO7A
mechanoreceptor differentiation (GO:0042490) 6.784PCDH15, USH1G, USH2A, MYO7A
single-organism developmental process (GO:0044767) 1.494PDZD7, USH1G, PCDH15, MYO7A
inner ear receptor cell differentiation (GO:0060113) 7.024PCDH15, USH1G, USH2A, MYO7A
establishment of localization (GO:0051234) 1.484PDZD7, CDH23, USH2A, MYO7A
organelle organization (GO:0006996) 2.023PCDH15, MYO7A, HARS
establishment of protein localization (GO:0045184) 2.533PDZD7, USH2A, MYO7A
cellular component assembly (GO:0022607) 2.143PCDH15, USH1C, MYO7A
anatomical structure morphogenesis (GO:0009653) 2.533PCDH15, USH1G, MYO7A
anatomical structure development (GO:0048856) 1.583PDZD7, PCDH15, MYO7A
regulation of cellular process (GO:0050794) 0.53CLRN1, USH1C, USH2A
auditory receptor cell stereocilium organization (GO:0060088) 7.243PDZD7, PCDH15, MYO7A
epidermal cell differentiation (GO:0009913) 5.133PCDH15, USH2A, MYO7A
epithelial cell differentiation (GO:0030855) 3.983PCDH15, USH2A, MYO7A
regulation of biological quality (GO:0065008) 1.683CDH23, USH1C, CIB2
regulation of biological process (GO:0050789) 0.453CLRN1, USH1C, USH2A
hair cell differentiation (GO:0035315) 7.023PCDH15, USH2A, MYO7A
homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) 4.682PCDH15, CDH23
embryonic morphogenesis (GO:0048598) 3.722USH1G, MYO7A
protein localization (GO:0008104) 2.362USH1C, MYO7A
detection of external stimulus (GO:0009581) 4.982PDZD7, PCDH15
ion homeostasis (GO:0050801) 3.422CDH23, CIB2
cell development (GO:0048468) 3.282PDZD7, MYO7A
behavior (GO:0007610) 3.472PCDH15, CDH23
movement of cell or subcellular component (GO:0006928) 2.612CLRN1, MYO7A
homeostatic process (GO:0042592) 2.612CDH23, CIB2
cell adhesion (GO:0007155) 2.822PCDH15, CDH23
detection of stimulus involved in sensory perception (GO:0050906) 3.462PDZD7, PCDH15
calcium ion homeostasis (GO:0055074) 3.972CDH23, CIB2
inorganic ion homeostasis (GO:0098771) 3.432CDH23, CIB2
regulation of cell projection organization (GO:0031344) 3.382CLRN1, USH1C
divalent inorganic cation homeostasis (GO:0072507) 3.92CDH23, CIB2
organelle assembly (GO:0070925) 3.752PCDH15, MYO7A
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962CDH23, CIB2
detection of mechanical stimulus (GO:0050982) 5.942PDZD7, PCDH15
response to mechanical stimulus (GO:0009612) 4.412PDZD7, PCDH15
cellular metal ion homeostasis (GO:0006875) 3.752CDH23, CIB2
neuroepithelial cell differentiation (GO:0060563) 6.512PCDH15, MYO7A
biological adhesion (GO:0022610) 2.812PCDH15, CDH23
columnar/cuboidal epithelial cell differentiation (GO:0002065) 5.842PCDH15, MYO7A
cellular homeostasis (GO:0019725) 3.232CDH23, CIB2
locomotory behavior (GO:0007626) 4.532PCDH15, CDH23
detection of abiotic stimulus (GO:0009582) 4.962PDZD7, PCDH15
detection of mechanical stimulus involved in sensory perception (GO:0050974) 6.432PDZD7, PCDH15
neuron development (GO:0048666) 4.82PDZD7, MYO7A
actin filament organization (GO:0007015) 4.542PCDH15, CLRN1
cell-cell adhesion (GO:0098609) 3.342PCDH15, CDH23
cellular calcium ion homeostasis (GO:0006874) 4.012CDH23, CIB2
transport (GO:0006810) 1.512CDH23, MYO7A
cellular ion homeostasis (GO:0006873) 3.572CDH23, CIB2
detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) 7.092PDZD7, PCDH15
inner ear morphogenesis (GO:0042472) 5.622USH1G, MYO7A
cellular cation homeostasis (GO:0030003) 3.62CDH23, CIB2
metal ion homeostasis (GO:0055065) 3.612CDH23, CIB2
cation homeostasis (GO:0055080) 3.462CDH23, CIB2
response to chemical (GO:0042221) 1.982PCDH15, CIB2
cellular chemical homeostasis (GO:0055082) 3.42CDH23, CIB2
regulation of cellular component organization (GO:0051128) 2.012CLRN1, USH1C
cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742) 4.392PCDH15, CDH23
response to abiotic stimulus (GO:0009628) 2.82PDZD7, PCDH15
inner ear development (GO:0048839) 5.762PCDH15, MYO7A
macromolecule localization (GO:0033036) 2.342USH1C, MYO7A
detection of stimulus (GO:0051606) 3.222PDZD7, PCDH15
response to external stimulus (GO:0009605) 2.552PDZD7, PCDH15
regulation of cytosolic calcium ion concentration (GO:0051480) 4.412CDH23, CIB2
auditory receptor cell differentiation (GO:0042491) 7.532PCDH15, MYO7A
chemical homeostasis (GO:0048878) 2.972CDH23, CIB2

NET-GE enrichment

Term New enriched termICP valueGenes
actin filament bundle organization (GO:0061572) NEW5.820.008CDH23, USH1C, MYO7A
cell projection organization (GO:0030030) -3.140.001MYO7A, CLRN1, CDH23, PCDH15, USH2A, DFNB31, USH1C, ADGRV1
auditory receptor cell stereocilium organization (GO:0060088) -7.240.0CLRN1, PCDH15, USH1C, MYO7A
detection of mechanical stimulus involved in sensory perception (GO:0050974) -6.430.0PCDH15, CDH23, USH2A, ADGRV1
detection of stimulus involved in sensory perception (GO:0050906) -3.460.014CDH23, PCDH15, USH1C, USH2A, ADGRV1
inner ear receptor cell differentiation (GO:0060113) -7.020.0USH1G, USH2A, USH1C, MYO7A, DFNB31
hair cell differentiation (GO:0035315) -7.020.009USH2A, USH1C, MYO7A, DFNB31
detection of mechanical stimulus (GO:0050982) -5.940.0PCDH15, USH2A, CDH23, ADGRV1, DFNB31
response to mechanical stimulus (GO:0009612) -4.410.004PCDH15, USH2A, CDH23, ADGRV1, DFNB31
neurological system process (GO:0050877) -2.640.0MYO7A, USH1G, CDH23, PCDH15, USH2A, DFNB31, CLRN1, USH1C, ADGRV1
sensory perception of mechanical stimulus (GO:0050954) -4.790.0MYO7A, USH1G, CDH23, PCDH15, USH2A, DFNB31, CLRN1, USH1C, ADGRV1
system process (GO:0003008) -2.30.0MYO7A, USH1G, CDH23, PCDH15, USH2A, DFNB31, CLRN1, USH1C, ADGRV1
detection of external stimulus (GO:0009581) -4.980.0CDH23, PCDH15, USH2A, DFNB31, USH1C, ADGRV1
detection of abiotic stimulus (GO:0009582) -4.960.0CDH23, PCDH15, USH2A, DFNB31, USH1C, ADGRV1
multicellular organismal process (GO:0032501) -1.450.0MYO7A, USH1G, CDH23, CIB2, PCDH15, ADGRV1, DFNB31, CLRN1, USH1C, USH2A
neuron differentiation (GO:0030182) -4.170.002MYO7A, USH1G, PCDH15, DFNB31, USH1C, USH2A
sensory perception of sound (GO:0007605) -4.820.0MYO7A, USH1G, CDH23, PCDH15, USH2A, DFNB31, CLRN1, USH1C, ADGRV1
actin filament bundle assembly (GO:0051017) NEW5.880.008CDH23, USH1C, MYO7A
equilibrioception (GO:0050957) -7.940.0CDH23, USH1G, PCDH15, MYO7A, CLRN1, USH1C
visual perception (GO:0007601) -4.410.0MYO7A, CLRN1, CDH23, PCDH15, USH2A, DFNB31, USH1C, ADGRV1
sensory perception (GO:0007600) -2.930.0MYO7A, USH1G, CDH23, PCDH15, USH2A, DFNB31, CLRN1, USH1C, ADGRV1
sensory perception of light stimulus (GO:0050953) -4.40.0MYO7A, USH1G, CDH23, PCDH15, USH2A, DFNB31, CLRN1, USH1C, ADGRV1
inner ear receptor stereocilium organization (GO:0060122) -6.470.0MYO7A, CLRN1, PCDH15, USH2A, DFNB31, USH1C, ADGRV1
maintenance of organ identity (GO:0048496) NEW8.120.006USH2A, ADGRV1
parallel actin filament bundle assembly (GO:0030046) NEW8.340.001USH1C, MYO7A
actin filament organization (GO:0007015) -4.540.021CDH23, PCDH15, USH1C, MYO7A, CLRN1
inner ear morphogenesis (GO:0042472) -5.620.002USH1G, USH1C, MYO7A, DFNB31
detection of stimulus (GO:0051606) -3.220.028CDH23, PCDH15, USH2A, DFNB31, USH1C, ADGRV1
single-multicellular organism process (GO:0044707) -1.780.0MYO7A, USH1G, CDH23, CIB2, PCDH15, ADGRV1, DFNB31, CLRN1, USH1C, USH2A
detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) -7.090.009PCDH15, USH2A, ADGRV1
epidermal cell differentiation (GO:0009913) -5.130.002USH2A, USH1C, MYO7A, DFNB31
mechanoreceptor differentiation (GO:0042490) -6.780.0USH1G, USH2A, USH1C, MYO7A, DFNB31
photoreceptor cell maintenance (GO:0045494) -6.170.0MYO7A, USH1G, CDH23, CIB2, PCDH15, ADGRV1, DFNB31, CLRN1, USH1C, USH2A
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1110PDZD7, USH1G, CDH23, CIB2, PCDH15, HARS, MYO7A, CLRN1, USH1C, USH2A
cell projection (GO:0042995) 2.479PDZD7, USH1G, CDH23, CIB2, PCDH15, MYO7A, CLRN1, USH1C, USH2A
intracellular part (GO:0044424) 0.288PDZD7, USH1G, CIB2, PCDH15, HARS, MYO7A, USH1C, USH2A
neuron part (GO:0097458) 2.648PDZD7, USH1G, CDH23, CIB2, PCDH15, MYO7A, USH1C, USH2A
membrane (GO:0016020) 0.688USH1G, CDH23, CIB2, PCDH15, MYO7A, CLRN1, USH1C, USH2A
organelle (GO:0043226) 0.48PDZD7, USH1G, CIB2, PCDH15, HARS, MYO7A, USH1C, USH2A
cytoplasm (GO:0005737) 1.017USH1G, CIB2, PCDH15, HARS, MYO7A, USH1C, USH2A
plasma membrane (GO:0005886) 1.397CDH23, USH1G, CIB2, PCDH15, CLRN1, USH1C, USH2A
organelle part (GO:0044422) 0.797USH1G, CDH23, CIB2, PCDH15, MYO7A, USH1C, USH2A
cilium (GO:0005929) 3.897PDZD7, USH1G, CIB2, PCDH15, MYO7A, USH1C, USH2A
primary cilium (GO:0072372) 4.646USH1G, CIB2, PCDH15, MYO7A, USH1C, USH2A
actin-based cell projection (GO:0098858) 4.836CLRN1, CDH23, CIB2, PCDH15, MYO7A, USH1C
nonmotile primary cilium (GO:0031513) 5.146USH1G, CIB2, PCDH15, MYO7A, USH1C, USH2A
stereocilium (GO:0032420) 6.45CDH23, PCDH15, USH1C, MYO7A, CIB2
intracellular organelle (GO:0043229) 0.515USH1C, PDZD7, USH1G, HARS, MYO7A
photoreceptor inner segment (GO:0001917) 6.255USH1G, USH2A, USH1C, MYO7A, CIB2
membrane part (GO:0044425) 0.955CLRN1, PCDH15, CDH23, USH2A, MYO7A
extracellular region part (GO:0044421) 1.574PCDH15, PDZD7, USH2A, CIB2
integral component of membrane (GO:0016021) 1.144CLRN1, PCDH15, CDH23, USH2A
photoreceptor outer segment (GO:0001750) 5.784PCDH15, USH1C, MYO7A, CIB2
cytoplasmic part (GO:0044444) 0.824USH1C, USH1G, MYO7A, HARS
synapse (GO:0045202) 3.584PCDH15, USH1C, MYO7A, CIB2
membrane-bounded organelle (GO:0043227) 0.474PCDH15, PDZD7, HARS, MYO7A
cytosol (GO:0005829) 1.684USH1C, USH1G, MYO7A, HARS
intrinsic component of membrane (GO:0031224) 1.134CLRN1, PCDH15, CDH23, USH2A
protein complex (GO:0043234) 1.513PDZD7, USH2A, MYO7A
cytoskeleton (GO:0005856) 2.553USH1G, USH1C, MYO7A
photoreceptor connecting cilium (GO:0032391) 6.283USH1G, USH2A, MYO7A
macromolecular complex (GO:0032991) 1.353PDZD7, USH2A, MYO7A
intracellular membrane-bounded organelle (GO:0043231) 0.63PDZD7, MYO7A, HARS
intracellular non-membrane-bounded organelle (GO:0043232) 1.763USH1G, USH1C, MYO7A
cell projection part (GO:0044463) 2.973USH1G, USH2A, MYO7A
intracellular organelle part (GO:0044446) 0.813USH1G, USH2A, MYO7A
microvillus (GO:0005902) 5.693CLRN1, USH1C, MYO7A
non-membrane-bounded organelle (GO:0043228) 1.763USH1G, USH1C, MYO7A
cytoskeletal part (GO:0044430) 2.493USH1G, USH2A, MYO7A
cluster of actin-based cell projections (GO:0098862) 5.543PCDH15, USH1C, USH2A
stereocilium bundle (GO:0032421) 7.52PCDH15, USH2A
plasma membrane region (GO:0098590) 2.972USH2A, MYO7A
vesicle (GO:0031982) 1.642PCDH15, MYO7A
ciliary basal body (GO:0036064) 5.362USH1G, USH2A
apical plasma membrane (GO:0016324) 4.132USH2A, MYO7A
plasma membrane part (GO:0044459) 1.952USH2A, MYO7A
stereocilia coupling link (GO:0002139) 9.112PDZD7, USH2A
membrane-bounded vesicle (GO:0031988) 1.712PCDH15, MYO7A
extracellular region (GO:0005576) 2.182PCDH15, USH2A
USH2 complex (GO:1990696) 9.112PDZD7, USH2A
ciliary part (GO:0044441) 4.052USH1G, USH2A
microtubule organizing center (GO:0005815) 3.422USH1G, USH2A
stereocilia ankle link (GO:0002141) 9.112PDZD7, USH2A
extracellular space (GO:0005615) 2.632PDZD7, PCDH15

NET-GE enrichment

Term New enriched termICP valueGenes
cytoskeleton (GO:0005856) -2.550.024MYO7A, USH1G, CDH23, PCDH15, DFNB31, USH1C, USH2A
stereocilium (GO:0032420) -6.40.0CDH23, PCDH15, USH1C, MYO7A, DFNB31
primary cilium (GO:0072372) -4.640.003PCDH15, USH1C, MYO7A
actin cytoskeleton (GO:0015629) NEW4.390.031USH1G, USH1C, MYO7A, DFNB31
nonmotile primary cilium (GO:0031513) -5.140.001PCDH15, USH1C, MYO7A
neuron part (GO:0097458) -2.640.013DFNB31, PCDH15, USH1C, MYO7A, CIB2
microvillus (GO:0005902) -5.690.0DFNB31, CLRN1, CDH23, PCDH15, MYO7A, USH1C
photoreceptor inner segment (GO:0001917) -6.250.001USH1C, MYO7A, CIB2
synapse (GO:0045202) -3.580.001CDH23, CIB2, PCDH15, MYO7A, USH1C, USH2A
cilium (GO:0005929) -3.890.0PDZD7, MYO7A, CDH23, PCDH15, DFNB31, USH1C, USH2A
cell projection (GO:0042995) -2.470.007PDZD7, MYO7A, CLRN1, CDH23, HARS, PCDH15, DFNB31, USH1C, USH2A
photoreceptor outer segment (GO:0001750) -5.780.007PCDH15, USH1C, MYO7A
stereocilia ankle link complex (GO:0002142) NEW9.80.0USH2A, ADGRV1, DFNB31