Disease table of DEAFNESS, AUTOSOMAL DOMINANT OMIM ID: PS124900

Gene-disease associations table

Gene	Associated with DEAFNESS, AUTOSOMAL DOMINANT in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TECTA	ClinVar, OMIM, HUMSAVAR	HGNC link	11q23.3	2	PS220290, PS124900
MYH9	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.3	6	153650, 153640, PS124900, 600208, PS231200, 605249
MYH14	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.33	2	614369, PS124900
TMC1	ClinVar, OMIM, HUMSAVAR	HGNC link	9q21.13	2	PS220290, PS124900
COL11A2	ClinVar, OMIM, HUMSAVAR	HGNC link	6p21.32	6	PS108300, PS220290, 215150, 277610, PS124900, PS228520
MYO1A	ClinVar	HGNC link	12q13.3	1	PS124900
DIABLO	ClinVar, OMIM, HUMSAVAR	HGNC link	12q24.31	1	PS124900
P2RX2	ClinVar, OMIM, HUMSAVAR	HGNC link	12q24.33	1	PS124900
ACTG1	ClinVar, OMIM, HUMSAVAR	HGNC link	17q25.3	2	PS243310, PS124900
MIR96	ClinVar, OMIM	HGNC link	7q32.2	1	PS124900
GRHL2	ClinVar, OMIM	HGNC link	8q22.3	2	616029, PS124900
GJB3	ClinVar, OMIM, HUMSAVAR	HGNC link	1p34.3	3	133200, PS124900, PS220290
GJB2	ClinVar, OMIM, HUMSAVAR	HGNC link	13q12.11	7	124500, PS220290, 148210, PS124900, 602540, 148350, 149200
SIX1	ClinVar, OMIM	HGNC link	14q23.1	3	608389, 113650, PS124900
GJB6	ClinVar, OMIM, HUMSAVAR	HGNC link	13q12.11	3	PS220290, PS305100, PS124900
TBC1D24	ClinVar, OMIM, HUMSAVAR	HGNC link	16p13.3	6	PS220290, 605021, PS124900, PS308350, PS254800, 220500
EYA4	ClinVar, OMIM, HUMSAVAR	HGNC link	6q23.2	2	PS115200, PS124900
HOMER2	ClinVar, OMIM, HUMSAVAR	HGNC link	15q25.2	1	PS124900
COCH	ClinVar, OMIM, HUMSAVAR	HGNC link	14q12	1	PS124900
CCDC50	ClinVar, OMIM	HGNC link	3q28	1	PS124900
DIAPH1	ClinVar, OMIM	HGNC link	5q31.3	2	616632, PS124900
KCNQ4	ClinVar, OMIM, HUMSAVAR	HGNC link	1p34.2	1	PS124900
CRYM	ClinVar, OMIM, HUMSAVAR	HGNC link	16p12.2	1	PS124900
POU4F3	ClinVar, OMIM, HUMSAVAR	HGNC link	5q32	1	PS124900
TNC	ClinVar, OMIM, HUMSAVAR	HGNC link	9q33.1	1	PS124900
OSBPL2	OMIM	HGNC link	20q13.33	1	PS124900
KITLG	OMIM	HGNC link	12q21.32	3	PS227220, PS124900, 145250
CEACAM16	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.31	1	PS124900
DFNA5	ClinVar, OMIM	HGNC link	7p15.3	1	PS124900
SLC17A8	ClinVar, OMIM, HUMSAVAR	HGNC link	12q23.1	1	PS124900
MYO6	ClinVar, OMIM, HUMSAVAR	HGNC link	6q14.1	2	PS220290, PS124900
WFS1	ClinVar, OMIM, HUMSAVAR	HGNC link	4p16.1	5	PS124900, 222300, PS116200, 614296, 125853
MYO7A	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.5	4	PS124900, PS220290, PS268000, PS276900

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 595	2	GJB6, GJB2

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
13q12.11	2	GJB6, GJB2

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
13q12	2	GJB6, GJB2
12q24	2	DIABLO, P2RX2
19q13	2	MYH14, CEACAM16
1p34	2	KCNQ4, GJB3

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12q2	4	DIABLO, SLC17A8, P2RX2, KITLG
13q1	2	GJB6, GJB2
19q1	2	MYH14, CEACAM16
1p3	2	KCNQ4, GJB3
16p1	2	CRYM, TBC1D24
5q3	2	DIAPH1, POU4F3

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1p	2	KCNQ4, GJB3
14q	2	COCH, SIX1
5q	2	DIAPH1, POU4F3
19q	2	MYH14, CEACAM16
6q	2	MYO6, EYA4
12q	5	DIABLO, KITLG, P2RX2, SLC17A8, MYO1A
13q	2	GJB6, GJB2
11q	2	MYO7A, TECTA
9q	2	TNC, TMC1
16p	2	CRYM, TBC1D24

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	MYO7A, TECTA
13	2	GJB6, GJB2
12	5	DIABLO, KITLG, P2RX2, SLC17A8, MYO1A
16	2	CRYM, TBC1D24
19	2	MYH14, CEACAM16
1	2	KCNQ4, GJB3
5	2	DIAPH1, POU4F3
7	2	MIR96, DFNA5
6	3	MYO6, EYA4, COL11A2
9	2	TNC, TMC1
14	2	COCH, SIX1

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
SIX1	YES	2	VEGFC, CDH1	0
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	TNC, COL11A2

regulated gene	associated to this disease	# TFs	TFs
MYH9	YES	2	USF1, USF2
COL11A2	YES	7	SP1, SP7, SOX9, ERG, SP3, EWSR1, SOX10
GRHL2	YES	1	ZEB1
TNC	YES	8	SP1, ETS2, JUN, SMAD3, SMAD4, RELA, NFKB1, ETS1
WFS1	YES	1	XBP1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
MYH9	MYH14	Yes	14	SP1, FBXO25, MYL12A, MYL6, OTUD6B, CDC73, SIRT7, MYL9, PIK3R2, PAN2, ESR1, SHC1, MCM2, LGR4
MYH9	MYO1A	No	2	CUL1, FBXO25
MYH9	DIABLO	No	2	LIMCH1, LIMA1
MYH9	ACTG1	Yes	42	FN1, CDK2, CORO1B, MYO19, HSP90AB1, TSGA10, HSPA5, LIMA1, BCAP31, SP1, GRB2, IQGAP1, CFL1, CTTN, MCM2, ACTA1, MYO18A, DBN1, SHC1, ANLN, ITGA4, UBASH3B, EED, ACTG1, ACTBL2, HSP90AA1, CFL2, ACTB, PPP1CB, DSTN, FBXO25, MYO1C, PPP1CC, CORO1C, TRAF3IP1, PDLIM7, CAPZA2, MYH10, FLNA, YWHAQ, MYO5C, LGR4
MYH9	GJB2	No	3	MUC13, PACSIN3, ANTXR1
MYH9	HOMER2	No	1	LZTS2
MYH9	CCDC50	Yes	1	LIMA1
MYH9	DIAPH1	No	8	FN1, CDC5L, VCAM1, IQGAP1, MYO1E, NTRK1, GRB2, SNW1
MYH9	KCNQ4	No	1	HSP90AA1
MYH9	CRYM	No	1	TERF1
MYH9	TNC	No	1	FN1
MYH9	DFNA5	No	3	NTRK1, SNW1, CDC5L
MYH9	MYO6	Yes	28	PICALM, CLTB, ANLN, TP53, PAN2, SP1, CLTC, MYO6, CAPZA1, MYO18A, DBN1, GTSE1, DAB2, PPP1CB, MYH10, MYO1C, MYO19, CDK2, ALK, MYO5C, ACTR2, CAPZA2, AP2A1, ESR1, NTRK1, FBXO25, FLNA, SYNPO
MYH9	WFS1	No	3	SYVN1, TERF1, ANTXR1
MYH9	MYO7A	No	1	CALM1
MYH14	MYO1A	No	1	FBXO25
MYH14	ACTG1	No	9	SP1, MCM2, SUZ12, GAN, MYH9, CCDC8, FBXO25, SHC1, LGR4
MYH14	CCDC50	No	1	MYH9
MYH14	CRYM	No	1	C7ORF25
MYH14	MYO6	No	5	SP1, FBXO25, MYH9, ESR1, PAN2
MYO1A	ACTG1	No	1	FBXO25
MYO1A	MYO6	No	1	FBXO25
DIABLO	ACTG1	No	4	LIMA1, EEF1A1, UBL4A, TRAF2
DIABLO	GJB3	No	1	ELAVL1
DIABLO	CCDC50	No	1	LIMA1
DIABLO	OSBPL2	No	1	ELAVL1
DIABLO	DFNA5	No	1	BIRC6
DIABLO	MYO6	No	1	ABCE1
ACTG1	COCH	No	1	FBXO6
ACTG1	CCDC50	No	4	MYH9, LIMA1, CORO1C, CALML3
ACTG1	DIAPH1	No	3	GRB2, IQGAP1, FN1
ACTG1	KCNQ4	No	1	HSP90AA1
ACTG1	TNC	No	1	FN1
ACTG1	MYO6	No	20	SP1, MYO1C, CDK2, CALML3, ACTB, ANLN, MYO18A, PPP1CB, TPM1, MYO19, CAPZA2, CDH1, TMOD3, FLNA, MYO5C, FBXO25, FBXO6, MYH10, MYH9, DBN1
ACTG1	WFS1	No	2	EIF6, MAPK6
ACTG1	MYO7A	No	1	CDH1
GRHL2	HOMER2	No	1	APP
GJB3	GJB2	No	1	CNST
GJB3	GJB6	No	1	CNST
GJB3	OSBPL2	No	1	ELAVL1
GJB2	GJB6	No	1	CNST
GJB2	WFS1	No	1	ANTXR1
SIX1	EYA4	Yes	0
SIX1	DIAPH1	No	1	SKI
HOMER2	MYO6	No	1	UBXN1
COCH	MYO6	No	1	FBXO6
CCDC50	DFNA5	No	1	EGFR
CCDC50	MYO6	No	3	UBC, MYH9, CALML3
DIAPH1	TNC	No	1	FN1
DIAPH1	DFNA5	No	3	NTRK1, SNW1, CDC5L
DIAPH1	MYO6	No	1	NTRK1
CRYM	MYO6	No	1	RNF126
CRYM	WFS1	No	1	TERF1
DFNA5	MYO6	No	1	NTRK1
MYO6	MYO7A	No	1	CDH1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MYH9	MYH14	Yes	binding	56	RAC1, HSP90AB1, RAB11A, MYH8, MYOM1, ROCK1, MYH6, MYL7, MYL12A, MYL6B, MYL12B, MYL2, MYLPF, MYL1, MYH11, MYH2, FCHO2, RHOA, ACTA1, FCHO1, MYH1, MYBPC3, TPM2, ACTG2, EXOC6, KIF3B, MYL5, POTEF, TPM3, ACTA2, MYH4, KIF5B, ACTC1, IQGAP1, HSP90AA1, UBC, MYL9, CGN, RHOC, MYH7, MYL10, GAS7, KIF3C, RHOB, MYL3, RAB11B, EXOC6B, MYL6, RAB25, MYH13, RABL2A, MYH3, ROCK2, MYH10, ACTR1A, KIF5A
MYH9	MYO1A	No	-	1	ACTR1A
MYH9	DIABLO	No	-	1	UBC
MYH9	HOMER2	No	-	1	RAC1
MYH9	CCDC50	No	-	1	UBC
MYH9	DIAPH1	No	-	7	RAC1, RHOA, ACTA1, IQGAP1, RHOC, UBC, RHOB
MYH9	TNC	No	-	1	RHOA
MYH9	OSBPL2	No	-	1	UBC
MYH9	DFNA5	No	-	1	UBC
MYH9	MYO6	No	-	4	UBC, MYL6B, ACTA1, MYL6
MYH9	WFS1	No	-	1	UBC
MYH14	MYO1A	No	-	3	ACTR1A, RAC3, ACTR1B
MYH14	DIABLO	No	-	1	UBC
MYH14	SIX1	No	-	2	MYOD1, MYOG
MYH14	GJB6	No	-	1	TJP1
MYH14	HOMER2	No	-	3	RAC1, CDC42, RAC3
MYH14	CCDC50	No	-	1	UBC
MYH14	DIAPH1	No	-	8	RAC1, RHOA, ACTA1, IQGAP1, CDC42, RHOC, UBC, RHOB
MYH14	TNC	No	-	2	TNNC1, RHOA
MYH14	OSBPL2	No	-	1	UBC
MYH14	KITLG	No	-	2	NR4A1, MYB
MYH14	DFNA5	No	-	1	UBC
MYH14	MYO6	No	-	7	MYL6, RAB8A, ACTA1, CDC42, UBC, MYL6B, RAC3
MYH14	WFS1	No	-	1	UBC
MYO1A	HOMER2	No	-	1	RAC3
MYO1A	MYO6	Yes	binding	8	MYO1C, ESPN, CD2AP, MYO3A, RAC3, MYO9B, CALM2, DPYSL3
DIABLO	CCDC50	No	-	1	UBC
DIABLO	DIAPH1	No	-	1	UBC
DIABLO	OSBPL2	No	-	1	UBC
DIABLO	KITLG	No	-	1	BAX
DIABLO	DFNA5	No	-	1	UBC
DIABLO	MYO6	No	-	1	UBC
DIABLO	WFS1	No	-	1	UBC
GRHL2	SIX1	No	-	1	CDH1
GRHL2	EYA4	No	-	1	ERBB3
GRHL2	MYO6	No	-	1	CDH1
GJB2	GJB6	Yes	binding	1	CNST
SIX1	EYA4	Yes	activation, binding	4	PAX3, PAX6, PAX7, DACH1
SIX1	TNC	No	-	1	PAX6
SIX1	MYO6	No	-	1	CDH1
EYA4	CCDC50	No	-	1	EGFR
EYA4	TNC	No	-	2	PAX6, EGFR
EYA4	KITLG	No	-	1	EGFR
HOMER2	DIAPH1	No	-	2	RAC1, CDC42
HOMER2	MYO6	No	-	3	MYO18B, CDC42, RAC3
CCDC50	DIAPH1	No	-	1	UBC
CCDC50	TNC	No	-	1	EGFR
CCDC50	OSBPL2	No	-	1	UBC
CCDC50	KITLG	No	-	1	EGFR
CCDC50	DFNA5	No	-	1	UBC
CCDC50	MYO6	No	-	1	UBC
CCDC50	WFS1	No	-	1	UBC
DIAPH1	TNC	No	-	2	RHOA, MKL1
DIAPH1	OSBPL2	No	-	1	UBC
DIAPH1	DFNA5	No	-	1	UBC
DIAPH1	MYO6	No	-	3	UBC, ACTA1, CDC42
DIAPH1	WFS1	No	-	1	UBC
KCNQ4	TNC	No	-	1	SRC
TNC	KITLG	No	-	1	EGFR
TNC	MYO6	No	-	1	FHL2
OSBPL2	DFNA5	No	-	1	UBC
OSBPL2	MYO6	No	-	1	UBC
OSBPL2	WFS1	No	-	1	UBC
DFNA5	MYO6	No	-	2	UBC, TP53
DFNA5	WFS1	No	-	1	UBC
MYO6	WFS1	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
MYH9	ACTG1	No	-	1	ACTB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
MYH14	ACTG1	Yes	2	MYH14, ACTG1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Focal adhesion	hsa04510	4.92	4	TNC, ACTG1, COL11A2, DIAPH1
Regulation of actin cytoskeleton	hsa04810	4.9	4	MYH9, ACTG1, MYH14, DIAPH1
Tight junction	hsa04530	5.53	3	MYH9, ACTG1, MYH14
Salmonella infection	hsa05132	6.29	3	MYH9, ACTG1, MYH14
PI3K-Akt signaling pathway	hsa04151	4.21	3	TNC, COL11A2, KITLG
ECM-receptor interaction	hsa04512	6.09	2	TNC, COL11A2
Shigellosis	hsa05131	6.74	2	ACTG1, DIAPH1
Platelet activation	hsa04611	5.66	2	ACTG1, COL11A2
Glutamatergic synapse	hsa04724	5.84	2	SLC17A8, HOMER2
Rap1 signaling pathway	hsa04015	4.97	2	ACTG1, KITLG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Salmonella infection (hsa05132)	-	6.29	0.034	MYH9, ACTG1, MYH14
Cellular community	NEW	3.57	0.023	TNC, DIAPH1, COL11A2, ACTG1, MYH14, MYH9
Cell motility	NEW	4.9	0.044	MYH9, ACTG1, MYH14, DIAPH1
Focal adhesion (hsa04510)	-	4.92	0.042	TNC, ACTG1, COL11A2, DIAPH1
Regulation of actin cytoskeleton (hsa04810)	-	4.9	0.044	MYH9, ACTG1, MYH14, DIAPH1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	6	KITLG, DIAPH1, ACTG1, MYH9, MYH14, MYO7A
Membrane Trafficking	R-HSA-199991	5.26	5	GJB6, GJB3, ACTG1, GJB2, MYO6
Gap junction trafficking	R-HSA-190828	7.59	5	GJB6, GJB3, ACTG1, GJB2, MYO6
Gap junction trafficking and regulation	R-HSA-157858	7.52	5	GJB6, GJB3, ACTG1, GJB2, MYO6
Vesicle-mediated transport	R-HSA-5653656	4.33	5	GJB6, GJB3, ACTG1, GJB2, MYO6
RHO GTPase Effectors	R-HSA-195258	4.94	4	MYH9, ACTG1, MYH14, DIAPH1
Axon guidance	R-HSA-422475	3.93	4	MYH9, ACTG1, MYH14, KITLG
Signaling by Rho GTPases	R-HSA-194315	4.43	4	MYH9, ACTG1, MYH14, DIAPH1
Developmental Biology	R-HSA-1266738	3.48	4	MYH9, ACTG1, MYH14, KITLG
Innate Immune System	R-HSA-168249	3.17	3	MYH9, ACTG1, KITLG
EPH-Ephrin signaling	R-HSA-2682334	6.43	3	MYH9, ACTG1, MYH14
Immune System	R-HSA-168256	2.37	3	MYH9, ACTG1, KITLG
Gap junction assembly	R-HSA-190861	8.03	3	GJB6, GJB3, GJB2
Signaling by PDGF	R-HSA-186797	4.53	2	ACTG1, KITLG
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	2	ACTG1, KITLG
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	ACTG1, KITLG
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	ACTG1, KITLG
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	2	ACTG1, KITLG
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	ACTG1, KITLG
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	2	ACTG1, KITLG
Interleukin-2 signaling	R-HSA-451927	5.05	2	ACTG1, KITLG
Frs2-mediated activation	R-HSA-170968	5.12	2	ACTG1, KITLG
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	ACTG1, KITLG
Extracellular matrix organization	R-HSA-1474244	4.91	2	TNC, COL11A2
IGF1R signaling cascade	R-HSA-2428924	4.85	2	ACTG1, KITLG
Downstream signal transduction	R-HSA-186763	4.65	2	ACTG1, KITLG
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	2	ACTG1, KITLG
Signaling by ERBB4	R-HSA-1236394	4.7	2	ACTG1, KITLG
Signaling by Insulin receptor	R-HSA-74752	4.73	2	ACTG1, KITLG
RHO GTPases activate PAKs	R-HSA-5627123	8.59	2	MYH9, MYH14
RHO GTPases activate CIT	R-HSA-5625900	8.98	2	MYH9, MYH14
RHO GTPases activate PKNs	R-HSA-5625740	7.1	2	MYH9, MYH14
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	2	ACTG1, KITLG
Sema4D in semaphorin signaling	R-HSA-400685	8.23	2	MYH9, MYH14
Signalling by NGF	R-HSA-166520	4.23	2	ACTG1, KITLG
Signaling by VEGF	R-HSA-194138	4.66	2	ACTG1, KITLG
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	ACTG1, KITLG
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	ACTG1, KITLG
IRS-mediated signalling	R-HSA-112399	4.87	2	ACTG1, KITLG
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	ACTG1, KITLG
DAP12 interactions	R-HSA-2172127	4.56	2	ACTG1, KITLG
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	ACTG1, KITLG
Neuronal System	R-HSA-112316	4.82	2	KCNQ4, MYO6
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.1	2	TNC, COL11A2
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	2	ACTG1, KITLG
Insulin receptor signalling cascade	R-HSA-74751	4.85	2	ACTG1, KITLG
Signaling by FGFR4	R-HSA-5654743	4.69	2	ACTG1, KITLG
Signaling by FGFR3	R-HSA-5654741	4.69	2	ACTG1, KITLG
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	ACTG1, KITLG
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	ACTG1, KITLG
RHO GTPases Activate Formins	R-HSA-5663220	6.01	2	ACTG1, DIAPH1
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.07	2	MYH9, ACTG1
Signaling by FGFR	R-HSA-190236	4.67	2	ACTG1, KITLG
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	5.23	2	MYH9, ACTG1
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	2	ACTG1, KITLG
Signaling by Leptin	R-HSA-2586552	5.1	2	ACTG1, KITLG
Interleukin receptor SHC signaling	R-HSA-912526	5.09	2	ACTG1, KITLG
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	ACTG1, KITLG
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	ACTG1, KITLG
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	ACTG1, KITLG
Signalling to ERKs	R-HSA-187687	5.04	2	ACTG1, KITLG
Semaphorin interactions	R-HSA-373755	6.92	2	MYH9, MYH14
Gap junction degradation	R-HSA-190873	9.4	2	ACTG1, MYO6
DAP12 signaling	R-HSA-2424491	4.64	2	ACTG1, KITLG
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	ACTG1, KITLG
Signaling by Interleukins	R-HSA-449147	4.71	2	ACTG1, KITLG
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	2	ACTG1, KITLG
Signaling by FGFR1	R-HSA-5654736	4.69	2	ACTG1, KITLG
Signaling by EGFR	R-HSA-177929	4.59	2	ACTG1, KITLG
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	2	ACTG1, KITLG
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	ACTG1, KITLG
Prolonged ERK activation events	R-HSA-169893	5.11	2	ACTG1, KITLG
RHO GTPases Activate ROCKs	R-HSA-5627117	8.89	2	MYH9, MYH14
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.4	2	MYH9, MYH14
Signaling by GPCR	R-HSA-372790	2.68	2	ACTG1, KITLG
Signaling by FGFR2	R-HSA-5654738	4.68	2	ACTG1, KITLG
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	ACTG1, KITLG
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	ACTG1, KITLG
Signalling to RAS	R-HSA-167044	5.08	2	ACTG1, KITLG
EPHA-mediated growth cone collapse	R-HSA-3928663	7.89	2	MYH9, MYH14
ARMS-mediated activation	R-HSA-170984	5.12	2	ACTG1, KITLG
SOS-mediated signalling	R-HSA-112412	5.15	2	ACTG1, KITLG
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	2	ACTG1, KITLG
Signaling by ERBB2	R-HSA-1227986	4.66	2	ACTG1, KITLG
MAPK family signaling cascades	R-HSA-5683057	4.89	2	ACTG1, KITLG
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	ACTG1, KITLG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Membrane Trafficking (R-HSA-199991)	-	5.26	0.006	GJB6, GJB3, ACTG1, GJB2, MYO6
Gap junction trafficking (R-HSA-190828)	-	7.59	0.0	GJB6, GJB3, ACTG1, GJB2, MYO6
Gap junction degradation (R-HSA-190873)	-	9.4	0.037	ACTG1, MYO6
Gap junction trafficking and regulation (R-HSA-157858)	-	7.52	0.0	GJB6, GJB3, ACTG1, GJB2, MYO6
Gap junction assembly (R-HSA-190861)	-	8.03	0.004	GJB6, GJB3, GJB2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	25	EYA4, MYO7A, DIAPH1, WFS1, CRYM, MYH9, MYO1A, GRHL2, COL11A2, MYO6, SIX1, POU4F3, MYH14, KITLG, TBC1D24, DIABLO, COCH, P2RX2, CCDC50, ACTG1, CEACAM16, KCNQ4, TNC, HOMER2, OSBPL2
protein binding (GO:0005515)	0.46	24	EYA4, MYO7A, DIAPH1, WFS1, CRYM, MYH9, MYO1A, GRHL2, COL11A2, MYO6, SIX1, MYH14, KITLG, TBC1D24, DIABLO, COCH, P2RX2, CCDC50, ACTG1, CEACAM16, KCNQ4, TNC, HOMER2, OSBPL2
organic cyclic compound binding (GO:0097159)	1.05	13	GRHL2, P2RX2, MYO6, DIAPH1, SIX1, ACTG1, MYH14, CRYM, MYH9, POU4F3, MYO1A, MYO7A, OSBPL2
heterocyclic compound binding (GO:1901363)	1.06	12	GRHL2, P2RX2, MYO6, DIAPH1, SIX1, ACTG1, MYH14, CRYM, MYH9, POU4F3, MYO1A, MYO7A
small molecule binding (GO:0036094)	1.89	10	P2RX2, MYO7A, MYO6, ACTG1, MYH9, CRYM, MYH14, POU4F3, MYO1A, OSBPL2
nucleoside phosphate binding (GO:1901265)	1.96	9	P2RX2, MYO7A, MYO6, ACTG1, MYH9, CRYM, MYH14, POU4F3, MYO1A
nucleotide binding (GO:0000166)	1.96	9	P2RX2, MYO7A, MYO6, ACTG1, MYH9, CRYM, MYH14, POU4F3, MYO1A
catalytic activity (GO:0003824)	1.05	8	EYA4, KITLG, MYO6, MYH9, CRYM, MYH14, MYO1A, MYO7A
macromolecular complex binding (GO:0044877)	2.61	8	GRHL2, MYO7A, MYO6, SIX1, MYH9, MYH14, MYO1A, COCH
adenyl nucleotide binding (GO:0030554)	2.4	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
carbohydrate derivative binding (GO:0097367)	2.03	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
ribonucleotide binding (GO:0032553)	2.19	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
adenyl ribonucleotide binding (GO:0032559)	2.41	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
identical protein binding (GO:0042802)	2.63	7	P2RX2, MYO7A, ACTG1, CRYM, MYH9, CEACAM16, HOMER2
purine nucleoside binding (GO:0001883)	2.22	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
ribonucleoside binding (GO:0032549)	2.22	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
purine ribonucleotide binding (GO:0032555)	2.2	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
purine nucleotide binding (GO:0017076)	2.19	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
purine ribonucleoside binding (GO:0032550)	2.22	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
ATP binding (GO:0005524)	2.43	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
nucleoside binding (GO:0001882)	2.21	7	P2RX2, MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A
hydrolase activity (GO:0016787)	1.9	6	EYA4, MYO7A, MYO6, MYH9, MYH14, MYO1A
cytoskeletal protein binding (GO:0008092)	3.02	6	DIAPH1, MYO6, MYH9, MYH14, MYO1A, MYO7A
transporter activity (GO:0005215)	2.57	6	SLC17A8, P2RX2, TMC1, KCNQ4, GJB2, GJB3
actin binding (GO:0003779)	3.74	6	DIAPH1, MYO6, MYH9, MYH14, MYO1A, MYO7A
transmembrane transporter activity (GO:0022857)	2.82	6	SLC17A8, P2RX2, TMC1, KCNQ4, GJB2, GJB3
protein complex binding (GO:0032403)	3.09	6	COCH, MYO7A, MYO6, MYH9, MYH14, MYO1A
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	5	MYO1A, MYH14, MYO6, MYH9, MYO7A
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	5	MYO1A, MYH9, MYO6, MYH14, MYO7A
actin filament binding (GO:0051015)	4.93	5	MYO1A, MYH14, MYO6, MYH9, MYO7A
nucleoside-triphosphatase activity (GO:0017111)	3.09	5	MYO1A, MYH9, MYO6, MYH14, MYO7A
pyrophosphatase activity (GO:0016462)	3.04	5	MYO1A, MYH14, MYO6, MYH9, MYO7A
channel activity (GO:0015267)	3.6	5	KCNQ4, TMC1, P2RX2, GJB2, GJB3
calmodulin binding (GO:0005516)	4.55	5	MYO1A, MYH14, MYO6, MYH9, MYO7A
nucleic acid binding (GO:0003676)	1.44	5	MYH9, SIX1, DIAPH1, POU4F3, GRHL2
passive transmembrane transporter activity (GO:0022803)	3.6	5	KCNQ4, TMC1, P2RX2, GJB2, GJB3
motor activity (GO:0003774)	4.81	5	MYO1A, MYH14, MYO6, MYH9, MYO7A
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	4	KCNQ4, TMC1, P2RX2, SLC17A8
substrate-specific transporter activity (GO:0022892)	2.72	4	KCNQ4, TMC1, P2RX2, SLC17A8
microfilament motor activity (GO:0000146)	6.65	4	MYH14, MYO6, MYH9, MYO7A
enzyme binding (GO:0019899)	2.27	4	CCDC50, ACTG1, WFS1, DIAPH1
ion transmembrane transporter activity (GO:0015075)	3.04	4	KCNQ4, TMC1, P2RX2, SLC17A8
protein dimerization activity (GO:0046983)	2.72	4	HOMER2, MYH9, MYO7A, CRYM
protein homodimerization activity (GO:0042803)	3.16	4	MYH9, HOMER2, CRYM, MYO7A
cation channel activity (GO:0005261)	4.04	3	KCNQ4, P2RX2, TMC1
nucleic acid binding transcription factor activity (GO:0001071)	2.65	3	SIX1, GRHL2, POU4F3
ATPase activity (GO:0016887)	3.65	3	MYH9, MYH14, MYO7A
DNA binding (GO:0003677)	1.92	3	SIX1, GRHL2, POU4F3
ubiquitin-like protein ligase binding (GO:0044389)	4.15	3	CCDC50, ACTG1, WFS1
sequence-specific DNA binding (GO:0043565)	2.79	3	SIX1, GRHL2, POU4F3
ATPase activity, coupled (GO:0042623)	3.97	3	MYH14, MYH9, MYO7A
structural molecule activity (GO:0005198)	3.1	3	ACTG1, COL11A2, TECTA
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	3	SIX1, GRHL2, POU4F3
ion channel activity (GO:0005216)	3.71	3	KCNQ4, P2RX2, TMC1
cation transmembrane transporter activity (GO:0008324)	3.32	3	KCNQ4, P2RX2, TMC1
regulatory region nucleic acid binding (GO:0001067)	3.03	3	SIX1, GRHL2, POU4F3
actin-dependent ATPase activity (GO:0030898)	7.17	3	MYH14, MYH9, MYO7A
protein domain specific binding (GO:0019904)	3.32	3	MYH9, HOMER2, MYO7A
ADP binding (GO:0043531)	6.24	3	MYH9, MYO6, MYO7A
transcription regulatory region DNA binding (GO:0044212)	3.03	3	SIX1, GRHL2, POU4F3
ubiquitin protein ligase binding (GO:0031625)	4.17	3	CCDC50, ACTG1, WFS1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	3	SIX1, GRHL2, POU4F3
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	3	SIX1, GRHL2, POU4F3
gated channel activity (GO:0022836)	3.96	3	KCNQ4, P2RX2, TMC1
regulatory region DNA binding (GO:0000975)	3.03	3	SIX1, GRHL2, POU4F3
receptor binding (GO:0005102)	2.43	3	DIAPH1, HOMER2, KITLG
substrate-specific channel activity (GO:0022838)	3.67	3	KCNQ4, P2RX2, TMC1
extracellular matrix structural constituent (GO:0005201)	5.37	2	COL11A2, TECTA
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	2	SIX1, POU4F3
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	2	SIX1, POU4F3
core promoter proximal region DNA binding (GO:0001159)	3.82	2	SIX1, POU4F3
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	4.31	2	SIX1, POU4F3
molecular function regulator (GO:0098772)	2.51	2	TBC1D24, KITLG
cation binding (GO:0043169)	1.4	2	EYA4, COL11A2
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	SIX1, POU4F3
ion binding (GO:0043167)	1.36	2	EYA4, COL11A2
wide pore channel activity (GO:0022829)	6.6	2	GJB3, GJB2
core promoter proximal region sequence-specific DNA binding (GO:0000987)	3.83	2	SIX1, POU4F3
double-stranded DNA binding (GO:0003690)	3.09	2	SIX1, POU4F3
metal ion binding (GO:0046872)	1.41	2	EYA4, COL11A2
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	3.94	2	SIX1, POU4F3
voltage-gated cation channel activity (GO:0022843)	4.83	2	KCNQ4, TMC1
poly(A) RNA binding (GO:0044822)	2.69	2	MYH9, DIAPH1
metal ion transmembrane transporter activity (GO:0046873)	3.71	2	KCNQ4, TMC1
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	2	KCNQ4, TMC1
voltage-gated ion channel activity (GO:0005244)	4.49	2	KCNQ4, TMC1
voltage-gated channel activity (GO:0022832)	4.49	2	KCNQ4, TMC1
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	SIX1, POU4F3
RNA binding (GO:0003723)	2.36	2	MYH9, DIAPH1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3.88	2	SIX1, POU4F3
chromatin binding (GO:0003682)	3.64	2	SIX1, GRHL2
gap junction channel activity (GO:0005243)	7.1	2	GJB3, GJB2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
microfilament motor activity (GO:0000146)	-	6.65	0.0	MYH9, MYO6, MYH14, MYO7A
actin-dependent ATPase activity (GO:0030898)	-	7.17	0.02	MYH9, MYO7A
actin binding (GO:0003779)	-	3.74	0.025	DIAPH1, MYO6, ACTG1, MYH9, MYH14, HOMER2, MYO1A, MYO7A
channel activity (GO:0015267)	-	3.6	0.033	P2RX2, MYO6, TMC1, ACTG1, KCNQ4, MYH9, GJB2, GJB3
calmodulin binding (GO:0005516)	-	4.55	0.01	WFS1, MYO7A, MYO6, MYH9, MYH14, MYO1A
ADP binding (GO:0043531)	-	6.24	0.013	MYH9, MYO6, MYO7A
passive transmembrane transporter activity (GO:0022803)	-	3.6	0.033	P2RX2, MYO6, TMC1, ACTG1, MYH9, KCNQ4, GJB2, GJB3
gap junction channel activity (GO:0005243)	-	7.1	0.03	GJB3, GJB2
motor activity (GO:0003774)	-	4.81	0.001	MYO7A, MYO6, ACTG1, MYH9, MYH14, MYO1A

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism process (GO:0044699)	0.48	27	EYA4, DFNA5, MYO7A, DIAPH1, WFS1, CRYM, MYH9, MYO1A, GJB3, GRHL2, COL11A2, MYO6, TMC1, POU4F3, MYH14, KITLG, TBC1D24, DIABLO, SLC17A8, P2RX2, ACTG1, KCNQ4, GJB2, TNC, GJB6, SIX1, OSBPL2
multicellular organismal process (GO:0032501)	1.45	26	EYA4, DFNA5, MYO7A, DIAPH1, SLC17A8, CRYM, MYH9, MYO1A, GJB3, GRHL2, COL11A2, MYO6, SIX1, POU4F3, MYH14, WFS1, TECTA, COCH, P2RX2, CCDC50, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, TMC1
cellular process (GO:0009987)	0.26	25	EYA4, DFNA5, MYO7A, DIAPH1, CRYM, MYH9, MYO1A, GJB3, GRHL2, COL11A2, MYO6, TMC1, POU4F3, MYH14, KITLG, TBC1D24, DIABLO, WFS1, P2RX2, ACTG1, KCNQ4, GJB2, TNC, GJB6, SIX1
sensory perception of sound (GO:0007605)	4.82	24	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CCDC50, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, SIX1
neurological system process (GO:0050877)	2.64	24	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CCDC50, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, SIX1
sensory perception (GO:0007600)	2.93	24	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, COL11A2, MYO6, SIX1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CCDC50, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, TMC1
single-organism cellular process (GO:0044763)	0.65	24	DFNA5, MYO7A, DIAPH1, CRYM, MYH9, MYO1A, GJB3, GRHL2, COL11A2, MYO6, TMC1, POU4F3, MYH14, KITLG, TBC1D24, DIABLO, WFS1, P2RX2, ACTG1, KCNQ4, GJB2, TNC, GJB6, SIX1
sensory perception of mechanical stimulus (GO:0050954)	4.79	24	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CCDC50, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, SIX1
system process (GO:0003008)	2.3	24	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CCDC50, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, SIX1
biological regulation (GO:0065007)	0.39	23	EYA4, DFNA5, DIAPH1, WFS1, CRYM, MYH9, MYO1A, GRHL2, COL11A2, MYO6, SIX1, POU4F3, MYH14, KITLG, TBC1D24, DIABLO, COCH, P2RX2, ACTG1, KCNQ4, TNC, GJB6, HOMER2
regulation of biological process (GO:0050789)	0.45	22	EYA4, DFNA5, DIAPH1, COCH, CRYM, MYH9, MYO1A, GRHL2, KITLG, MYO6, SIX1, POU4F3, MYH14, TBC1D24, DIABLO, WFS1, P2RX2, ACTG1, KCNQ4, TNC, GJB6, HOMER2
regulation of cellular process (GO:0050794)	0.5	21	DIAPH1, COCH, DFNA5, KITLG, MYO6, GRHL2, GJB6, ACTG1, WFS1, CRYM, KCNQ4, TNC, MYH14, POU4F3, HOMER2, DIABLO, P2RX2, EYA4, TBC1D24, SIX1, MYH9
single-organism developmental process (GO:0044767)	1.49	18	SLC17A8, TNC, P2RX2, KITLG, COL11A2, EYA4, TMC1, GRHL2, POU4F3, KCNQ4, GJB6, MYH14, SIX1, WFS1, MYO7A, GJB3, GJB2, MYH9
developmental process (GO:0032502)	1.36	18	SLC17A8, TNC, P2RX2, KITLG, COL11A2, EYA4, GRHL2, TMC1, GJB3, WFS1, POU4F3, GJB6, KCNQ4, MYO7A, MYH14, GJB2, SIX1, MYH9
anatomical structure development (GO:0048856)	1.58	17	SLC17A8, EYA4, TNC, P2RX2, KITLG, COL11A2, GRHL2, TMC1, WFS1, POU4F3, GJB6, MYH14, SIX1, MYO7A, GJB2, GJB3, MYH9
positive regulation of biological process (GO:0048518)	1.2	14	GRHL2, DFNA5, KITLG, MYO6, SIX1, ACTG1, TNC, POU4F3, MYH9, WFS1, DIAPH1, P2RX2, COCH, DIABLO
localization (GO:0051179)	1.4	14	DIAPH1, SLC17A8, P2RX2, MYO7A, MYO6, GJB3, TMC1, MYH9, CRYM, KCNQ4, MYO1A, GJB2, SIX1, OSBPL2
cellular component organization (GO:0016043)	1.24	13	GRHL2, P2RX2, DIAPH1, COL11A2, EYA4, ACTG1, MYH14, TNC, MYH9, MYO1A, MYO7A, GJB2, TBC1D24
cellular component organization or biogenesis (GO:0071840)	1.22	13	DIAPH1, GRHL2, P2RX2, MYO7A, COL11A2, EYA4, ACTG1, MYH14, TNC, MYH9, MYO1A, GJB2, TBC1D24
cellular developmental process (GO:0048869)	1.82	12	TNC, DFNA5, KITLG, COL11A2, GRHL2, SIX1, MYH14, POU4F3, MYH9, MYO7A, P2RX2, TMC1
positive regulation of cellular process (GO:0048522)	1.3	12	GRHL2, P2RX2, MYO6, DIAPH1, SIX1, TNC, POU4F3, MYH9, WFS1, DFNA5, KITLG, DIABLO
establishment of localization (GO:0051234)	1.48	11	SLC17A8, P2RX2, MYO6, TMC1, MYH9, CRYM, KCNQ4, MYO7A, GJB2, GJB3, OSBPL2
regulation of biological quality (GO:0065008)	1.68	11	WFS1, P2RX2, KITLG, COL11A2, GJB6, ACTG1, MYH14, CRYM, MYH9, DIAPH1, COCH
regulation of metabolic process (GO:0019222)	1.02	11	GRHL2, KITLG, MYO6, SIX1, TNC, CRYM, MYH9, WFS1, POU4F3, EYA4, DIABLO
regulation of macromolecule metabolic process (GO:0060255)	1.08	11	GRHL2, KITLG, MYO6, SIX1, TNC, CRYM, MYH9, WFS1, POU4F3, EYA4, DIABLO
transport (GO:0006810)	1.51	11	SLC17A8, P2RX2, MYO6, TMC1, KCNQ4, CRYM, MYH9, MYO7A, GJB2, GJB3, OSBPL2
anatomical structure morphogenesis (GO:0009653)	2.53	11	GRHL2, COL11A2, SIX1, MYH9, POU4F3, TNC, KCNQ4, MYO7A, MYH14, EYA4, GJB6
negative regulation of biological process (GO:0048519)	1.33	10	GRHL2, DFNA5, KITLG, GJB6, MYH9, CRYM, TNC, KCNQ4, WFS1, SIX1
response to stimulus (GO:0050896)	1.22	10	TNC, P2RX2, DIAPH1, MYO6, GJB6, EYA4, WFS1, GJB2, COCH, TMC1
regulation of cellular metabolic process (GO:0031323)	1.07	10	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, MYH9, WFS1, POU4F3, DIABLO
regulation of primary metabolic process (GO:0080090)	1.08	10	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, MYH9, WFS1, POU4F3, DIABLO
negative regulation of cellular process (GO:0048523)	1.41	10	GRHL2, DFNA5, KITLG, GJB6, MYH9, CRYM, TNC, KCNQ4, WFS1, SIX1
organic substance metabolic process (GO:0071704)	0.63	9	GRHL2, KITLG, COL11A2, SIX1, EYA4, CRYM, MYH9, WFS1, POU4F3
regulation of gene expression (GO:0010468)	1.37	9	GRHL2, MYO6, SIX1, TNC, CRYM, MYH9, WFS1, POU4F3, EYA4
positive regulation of metabolic process (GO:0009893)	1.74	9	GRHL2, KITLG, MYO6, SIX1, TNC, POU4F3, MYH9, WFS1, DIABLO
metabolic process (GO:0008152)	0.58	9	GRHL2, KITLG, COL11A2, SIX1, EYA4, CRYM, MYH9, WFS1, POU4F3
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	9	GRHL2, KITLG, MYO6, SIX1, TNC, POU4F3, MYH9, WFS1, DIABLO
animal organ development (GO:0048513)	2.53	8	SLC17A8, KITLG, COL11A2, SIX1, GRHL2, WFS1, GJB3, GJB2
macromolecule metabolic process (GO:0043170)	0.83	8	GRHL2, KITLG, COL11A2, SIX1, EYA4, POU4F3, MYH9, WFS1
single-multicellular organism process (GO:0044707)	1.78	8	GRHL2, P2RX2, COL11A2, SIX1, EYA4, MYH9, WFS1, GJB3
primary metabolic process (GO:0044238)	0.69	8	GRHL2, KITLG, SIX1, EYA4, POU4F3, MYH9, WFS1, CRYM
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	8	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
regulation of biosynthetic process (GO:0009889)	1.37	8	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
positive regulation of cellular metabolic process (GO:0031325)	1.81	8	GRHL2, KITLG, MYO6, SIX1, WFS1, POU4F3, MYH9, DIABLO
cell differentiation (GO:0030154)	2.14	8	GRHL2, DFNA5, COL11A2, SIX1, TNC, POU4F3, MYH9, MYO7A
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	8	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
movement of cell or subcellular component (GO:0006928)	2.61	8	KITLG, MYO6, SIX1, ACTG1, MYH9, POU4F3, MYH14, MYO7A
regulation of developmental process (GO:0050793)	2.1	8	GRHL2, KITLG, DIAPH1, SIX1, MYH14, MYH9, COCH, TBC1D24
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	8	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
signal transduction (GO:0007165)	1.28	8	WFS1, P2RX2, KITLG, MYO6, ACTG1, MYH9, HOMER2, DIABLO
regulation of cellular biosynthetic process (GO:0031326)	1.38	8	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
regulation of localization (GO:0032879)	1.94	8	WFS1, P2RX2, DIAPH1, MYO6, SIX1, KCNQ4, MYO1A, KITLG
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	8	GRHL2, KITLG, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
cellular response to stimulus (GO:0051716)	1.97	7	TNC, DIAPH1, MYO6, GJB6, EYA4, WFS1, GJB2
cellular component assembly (GO:0022607)	2.14	7	GRHL2, P2RX2, MYO7A, DIAPH1, ACTG1, MYO1A, GJB2
regulation of RNA metabolic process (GO:0051252)	1.52	7	GRHL2, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
cellular metabolic process (GO:0044237)	0.69	7	GRHL2, KITLG, SIX1, EYA4, POU4F3, WFS1, CRYM
regulation of transcription, DNA-templated (GO:0006355)	1.56	7	GRHL2, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
response to stress (GO:0006950)	1.8	7	WFS1, P2RX2, MYO6, EYA4, TNC, GJB2, COCH
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	7	GRHL2, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
regulation of RNA biosynthetic process (GO:2001141)	1.55	7	GRHL2, MYO6, SIX1, EYA4, CRYM, WFS1, POU4F3
positive regulation of biosynthetic process (GO:0009891)	2.29	6	GRHL2, MYO6, KITLG, SIX1, WFS1, POU4F3
regulation of response to stimulus (GO:0048583)	1.54	6	WFS1, P2RX2, KITLG, ACTG1, COCH, DFNA5
regulation of cellular component organization (GO:0051128)	2.01	6	COCH, DIAPH1, SIX1, MYH9, MYH14, TBC1D24
positive regulation of gene expression (GO:0010628)	2.35	6	TNC, MYO6, SIX1, GRHL2, POU4F3, MYH9
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	6	GRHL2, MYO6, KITLG, SIX1, WFS1, POU4F3
cell surface receptor signaling pathway (GO:0007166)	2.09	6	P2RX2, KITLG, ACTG1, MYH9, HOMER2, DIABLO
cell death (GO:0008219)	3.05	6	DFNA5, KITLG, SIX1, POU4F3, GJB6, DIABLO
cellular macromolecule metabolic process (GO:0044260)	0.93	6	GRHL2, KITLG, SIX1, WFS1, POU4F3, EYA4
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	6	COCH, DIAPH1, SIX1, MYH9, MYH14, TBC1D24
organic substance transport (GO:0071702)	2.15	6	SLC17A8, MYO6, CRYM, MYH9, MYO7A, OSBPL2
biological adhesion (GO:0022610)	2.81	6	TNC, KITLG, ACTG1, GRHL2, MYH9, TECTA
embryonic morphogenesis (GO:0048598)	3.72	6	GRHL2, GJB6, POU4F3, KCNQ4, MYO7A, SIX1
organ morphogenesis (GO:0009887)	3.55	6	GRHL2, COL11A2, GJB6, TNC, MYO7A, SIX1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	6	GRHL2, MYO6, KITLG, SIX1, WFS1, POU4F3
actin filament-based process (GO:0030029)	3.94	6	DIAPH1, MYO6, ACTG1, MYH9, MYH14, MYO7A
programmed cell death (GO:0012501)	3.1	6	DFNA5, KITLG, SIX1, POU4F3, GJB6, DIABLO
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	6	GRHL2, MYO6, KITLG, SIX1, WFS1, POU4F3
cell adhesion (GO:0007155)	2.82	6	TNC, KITLG, ACTG1, GRHL2, MYH9, TECTA
response to chemical (GO:0042221)	1.98	6	TNC, P2RX2, DIAPH1, MYO6, GJB6, GJB2
transmembrane transport (GO:0055085)	2.72	6	SLC17A8, P2RX2, TMC1, KCNQ4, GJB2, GJB3
single-organism localization (GO:1902578)	2.09	6	SLC17A8, MYH9, CRYM, KCNQ4, MYO7A, OSBPL2
cellular localization (GO:0051641)	2.32	6	DIAPH1, MYO6, SIX1, MYH9, MYO1A, MYO7A
single organism reproductive process (GO:0044702)	2.73	6	TNC, KITLG, GRHL2, MYH9, GJB2, GJB3
reproductive process (GO:0022414)	2.55	6	TNC, KITLG, GRHL2, MYH9, GJB2, GJB3
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	6	GRHL2, MYO6, SIX1, WFS1, CRYM, POU4F3
regulation of cell morphogenesis (GO:0022604)	3.4	5	COCH, TBC1D24, MYH9, DIAPH1, MYH14
protein localization (GO:0008104)	2.36	5	DIAPH1, MYH9, MYO6, SIX1, MYO7A
cell projection organization (GO:0030030)	3.14	5	MYO1A, MYH9, TBC1D24, TNC, MYO7A
regulation of transport (GO:0051049)	2.24	5	DIAPH1, KCNQ4, P2RX2, WFS1, MYO6
positive regulation of response to stimulus (GO:0048584)	2.18	5	ACTG1, P2RX2, COCH, DFNA5, KITLG
nitrogen compound metabolic process (GO:0006807)	1.13	5	SIX1, EYA4, POU4F3, CRYM, GRHL2
regulation of signaling (GO:0023051)	1.72	5	P2RX2, WFS1, DFNA5, KCNQ4, KITLG
regulation of cell communication (GO:0010646)	1.73	5	P2RX2, KCNQ4, DFNA5, WFS1, KITLG
regulation of apoptotic process (GO:0042981)	2.5	5	WFS1, SIX1, DFNA5, DIABLO, KITLG
multicellular organism development (GO:0007275)	2.54	5	EYA4, SIX1, GJB3, MYH9, GRHL2
organic cyclic compound metabolic process (GO:1901360)	1.26	5	CRYM, EYA4, SIX1, POU4F3, GRHL2
regulation of cell death (GO:0010941)	2.43	5	WFS1, DFNA5, SIX1, KITLG, DIABLO
regulation of programmed cell death (GO:0043067)	2.49	5	WFS1, SIX1, DFNA5, DIABLO, KITLG
positive regulation of catalytic activity (GO:0043085)	2.4	5	WFS1, TBC1D24, DIABLO, KITLG, GRHL2
positive regulation of molecular function (GO:0044093)	2.23	5	WFS1, TBC1D24, DIABLO, KITLG, GRHL2
regulation of molecular function (GO:0065009)	1.78	5	WFS1, TBC1D24, DIABLO, KITLG, GRHL2
macromolecule localization (GO:0033036)	2.34	5	DIAPH1, SIX1, MYO6, MYH9, MYO7A
regulation of cell proliferation (GO:0042127)	2.41	5	GJB6, SIX1, DFNA5, TNC, KITLG
apoptotic process (GO:0006915)	3.14	5	GJB6, SIX1, DFNA5, POU4F3, DIABLO
regulation of catalytic activity (GO:0050790)	1.97	5	WFS1, TBC1D24, DIABLO, KITLG, GRHL2
cellular aromatic compound metabolic process (GO:0006725)	1.3	5	SIX1, EYA4, POU4F3, CRYM, GRHL2
developmental process involved in reproduction (GO:0003006)	3.36	5	TNC, GJB3, GJB2, KITLG, GRHL2
single-organism transport (GO:0044765)	2.18	5	CRYM, SLC17A8, KCNQ4, OSBPL2, MYO7A
cell communication (GO:0007154)	3.04	5	TNC, GJB3, P2RX2, GJB2, GJB6
response to organic substance (GO:0010033)	2.2	5	GJB6, GJB2, P2RX2, TNC, DIAPH1
organelle organization (GO:0006996)	2.02	5	DIAPH1, MYH9, ACTG1, MYH14, MYO7A
inner ear development (GO:0048839)	5.76	5	GJB6, EYA4, SIX1, MYO7A, POU4F3
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	5	GRHL2, MYO6, SIX1, POU4F3, KITLG
cellular response to stress (GO:0033554)	2.51	5	TNC, EYA4, GJB2, WFS1, MYO6
RNA biosynthetic process (GO:0032774)	1.84	4	EYA4, SIX1, POU4F3, GRHL2
macromolecular complex subunit organization (GO:0043933)	2.14	4	EYA4, P2RX2, COL11A2, DIAPH1
actin cytoskeleton organization (GO:0030036)	4.1	4	MYH9, ACTG1, MYH14, DIAPH1
homeostatic process (GO:0042592)	2.61	4	WFS1, ACTG1, GJB6, COL11A2
cellular biosynthetic process (GO:0044249)	1.37	4	EYA4, SIX1, POU4F3, GRHL2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	4	EYA4, SIX1, POU4F3, GRHL2
cellular response to chemical stimulus (GO:0070887)	2.57	4	GJB6, GJB2, TNC, DIAPH1
organic cyclic compound biosynthetic process (GO:1901362)	1.66	4	EYA4, SIX1, POU4F3, GRHL2
response to organic cyclic compound (GO:0014070)	3.07	4	GJB2, P2RX2, TNC, DIAPH1
response to endogenous stimulus (GO:0009719)	2.79	4	GJB2, P2RX2, TNC, DIAPH1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	4	EYA4, SIX1, POU4F3, GRHL2
nucleic acid metabolic process (GO:0090304)	1.46	4	EYA4, SIX1, POU4F3, GRHL2
regulation of signal transduction (GO:0009966)	1.84	4	P2RX2, WFS1, DFNA5, KITLG
regulation of protein metabolic process (GO:0051246)	1.93	4	MYH9, WFS1, KITLG, DIABLO
positive regulation of protein metabolic process (GO:0051247)	2.43	4	MYH9, WFS1, KITLG, DIABLO
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	4	MYH9, WFS1, DIABLO, KITLG
nucleic acid-templated transcription (GO:0097659)	1.91	4	EYA4, SIX1, POU4F3, GRHL2
epithelial cell differentiation (GO:0030855)	3.98	4	SIX1, MYO7A, POU4F3, GRHL2
heterocycle biosynthetic process (GO:0018130)	1.7	4	EYA4, SIX1, POU4F3, GRHL2
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	4	SIX1, MYO6, GRHL2, POU4F3
response to oxygen-containing compound (GO:1901700)	2.57	4	GJB6, GJB2, P2RX2, TNC
organic substance biosynthetic process (GO:1901576)	1.34	4	EYA4, SIX1, POU4F3, GRHL2
cation transport (GO:0006812)	3.11	4	KCNQ4, TMC1, P2RX2, SLC17A8
ion transport (GO:0006811)	2.66	4	KCNQ4, TMC1, P2RX2, SLC17A8
visual perception (GO:0007601)	4.41	4	EYA4, POU4F3, WFS1, MYO7A
tissue development (GO:0009888)	3.27	4	GJB2, SIX1, MYH14, GRHL2
sensory perception of light stimulus (GO:0050953)	4.4	4	EYA4, WFS1, MYO7A, POU4F3
cellular macromolecule biosynthetic process (GO:0034645)	1.66	4	EYA4, SIX1, POU4F3, GRHL2
ion transmembrane transport (GO:0034220)	3.08	4	KCNQ4, TMC1, P2RX2, SLC17A8
biosynthetic process (GO:0009058)	1.32	4	EYA4, SIX1, POU4F3, GRHL2
regulation of cell shape (GO:0008360)	4.77	4	MYH9, COCH, MYH14, DIAPH1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	4	SIX1, MYO6, GRHL2, POU4F3
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	4	EYA4, SIX1, POU4F3, GRHL2
cytoskeleton organization (GO:0007010)	3.22	4	MYH9, ACTG1, MYH14, DIAPH1
regulation of intracellular signal transduction (GO:1902531)	2.31	4	P2RX2, WFS1, DFNA5, KITLG
heterocycle metabolic process (GO:0046483)	1.31	4	EYA4, SIX1, POU4F3, GRHL2
RNA metabolic process (GO:0016070)	1.59	4	EYA4, SIX1, POU4F3, GRHL2
response to abiotic stimulus (GO:0009628)	2.8	4	GJB6, TMC1, P2RX2, TNC
regulation of cellular protein metabolic process (GO:0032268)	1.99	4	MYH9, WFS1, DIABLO, KITLG
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	4	EYA4, SIX1, POU4F3, GRHL2
response to external stimulus (GO:0009605)	2.55	4	TNC, COCH, TMC1, GJB6
actin filament-based movement (GO:0030048)	5.54	4	MYH14, MYO6, MYH9, MYO7A
protein metabolic process (GO:0019538)	1.45	4	EYA4, WFS1, MYH9, KITLG
inner ear morphogenesis (GO:0042472)	5.62	4	KCNQ4, SIX1, MYO7A, POU4F3
positive regulation of RNA metabolic process (GO:0051254)	2.51	4	GRHL2, SIX1, MYO6, POU4F3
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	4	SIX1, MYO6, GRHL2, POU4F3
single-organism organelle organization (GO:1902589)	2.68	4	MYH9, ACTG1, MYH14, DIAPH1
macromolecule biosynthetic process (GO:0009059)	1.61	4	EYA4, SIX1, POU4F3, GRHL2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	4	GRHL2, SIX1, MYO6, POU4F3
transcription, DNA-templated (GO:0006351)	1.91	4	EYA4, SIX1, POU4F3, GRHL2
regulation of ion transport (GO:0043269)	3.4	4	KCNQ4, P2RX2, WFS1, DIAPH1
aromatic compound biosynthetic process (GO:0019438)	1.7	4	EYA4, SIX1, POU4F3, GRHL2
positive regulation of cell proliferation (GO:0008284)	3.01	3	SIX1, TNC, KITLG
embryonic organ morphogenesis (GO:0048562)	4.92	3	GJB6, SIX1, GRHL2
negative regulation of metabolic process (GO:0009892)	1.93	3	WFS1, SIX1, CRYM
actomyosin structure organization (GO:0031032)	5.4	3	MYH9, ACTG1, MYH14
developmental growth (GO:0048589)	4.05	3	GRHL2, TNC, POU4F3
single organism signaling (GO:0044700)	3.25	3	GJB2, P2RX2, TNC
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	WFS1, SIX1, CRYM
cell junction organization (GO:0034330)	4.51	3	GJB2, ACTG1, GRHL2
cell development (GO:0048468)	3.28	3	TMC1, P2RX2, MYO7A
regulation of homeostatic process (GO:0032844)	3.65	3	P2RX2, DIAPH1, KITLG
positive regulation of signaling (GO:0023056)	2.41	3	P2RX2, DFNA5, KITLG
embryo development (GO:0009790)	4.2	3	GJB3, MYH9, GRHL2
negative regulation of gene expression (GO:0010629)	2.48	3	WFS1, SIX1, CRYM
embryo development ending in birth or egg hatching (GO:0009792)	4.35	3	GJB3, MYH9, GRHL2
signaling (GO:0023052)	3.25	3	GJB2, P2RX2, TNC
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	3	WFS1, SIX1, CRYM
inner ear receptor cell differentiation (GO:0060113)	7.02	3	DFNA5, POU4F3, MYO7A
positive regulation of cell communication (GO:0010647)	2.41	3	P2RX2, DFNA5, KITLG
intracellular signal transduction (GO:0035556)	2.39	3	MYO6, KITLG, DIABLO
single-organism metabolic process (GO:0044710)	1.63	3	COL11A2, KITLG, CRYM
in utero embryonic development (GO:0001701)	4.4	3	GJB3, MYH9, GRHL2
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	WFS1, SIX1, CRYM
negative regulation of biosynthetic process (GO:0009890)	2.47	3	WFS1, SIX1, CRYM
positive regulation of hydrolase activity (GO:0051345)	2.91	3	TBC1D24, DIABLO, KITLG
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	3	WFS1, SIX1, CRYM
positive regulation of signal transduction (GO:0009967)	2.5	3	P2RX2, DFNA5, KITLG
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	3	WFS1, SIX1, CRYM
cellular component morphogenesis (GO:0032989)	3.5	3	MYH9, MYH14, GRHL2
positive regulation of immune system process (GO:0002684)	2.96	3	COCH, ACTG1, KITLG
negative regulation of apoptotic process (GO:0043066)	3.04	3	WFS1, SIX1, KITLG
regulation of immune system process (GO:0002682)	2.5	3	COCH, ACTG1, KITLG
transcription from RNA polymerase II promoter (GO:0006366)	3.38	3	SIX1, GRHL2, POU4F3
chordate embryonic development (GO:0043009)	4.38	3	GJB3, MYH9, GRHL2
cell migration (GO:0016477)	3.12	3	MYH9, SIX1, KITLG
negative regulation of programmed cell death (GO:0043069)	3.02	3	WFS1, SIX1, KITLG
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	3	MYH9, SIX1, GRHL2
skeletal system morphogenesis (GO:0048705)	4.98	3	GRHL2, SIX1, COL11A2
locomotion (GO:0040011)	2.91	3	MYH9, SIX1, KITLG
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	WFS1, SIX1, CRYM
reproductive structure development (GO:0048608)	4.08	3	GJB2, GJB3, KITLG
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	WFS1, SIX1, CRYM
neuron differentiation (GO:0030182)	4.17	3	DFNA5, MYO7A, POU4F3
cell proliferation (GO:0008283)	3.23	3	SIX1, GRHL2, KITLG
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	WFS1, SIX1, CRYM
negative regulation of cell death (GO:0060548)	2.95	3	WFS1, SIX1, KITLG
protein complex subunit organization (GO:0071822)	2.6	3	P2RX2, COL11A2, DIAPH1
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	3	WFS1, SIX1, CRYM
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	3	WFS1, SIX1, CRYM
protein transport (GO:0015031)	2.62	3	MYH9, MYO6, MYO7A
regulation of cell differentiation (GO:0045595)	2.42	3	SIX1, GRHL2, KITLG
metal ion transport (GO:0030001)	3.36	3	KCNQ4, TMC1, SLC17A8
regulation of multicellular organismal process (GO:0051239)	1.87	3	SIX1, GRHL2, KITLG
establishment of localization in cell (GO:0051649)	2.47	3	MYH9, MYO6, MYO7A
cell-cell signaling (GO:0007267)	3.35	3	GJB2, P2RX2, TNC
positive regulation of intracellular signal transduction (GO:1902533)	2.95	3	P2RX2, DFNA5, KITLG
catabolic process (GO:0009056)	2.38	3	WFS1, COL11A2, CRYM
cell junction assembly (GO:0034329)	4.86	3	GJB2, ACTG1, GRHL2
organelle localization (GO:0051640)	3.94	3	MYH9, MYO1A, MYO7A
growth (GO:0040007)	3.8	3	GRHL2, TNC, POU4F3
regulation of hydrolase activity (GO:0051336)	2.53	3	TBC1D24, DIABLO, KITLG
regulation of metal ion transport (GO:0010959)	3.94	3	WFS1, P2RX2, DIAPH1
response to biotic stimulus (GO:0009607)	3.09	3	GJB6, COCH, WFS1
cellular response to organic substance (GO:0071310)	2.78	3	TNC, GJB6, DIAPH1
cell motility (GO:0048870)	3.02	3	MYH9, SIX1, KITLG
negative regulation of RNA metabolic process (GO:0051253)	2.66	3	WFS1, SIX1, CRYM
regulation of calcium ion transport (GO:0051924)	4.38	3	WFS1, P2RX2, DIAPH1
mechanoreceptor differentiation (GO:0042490)	6.78	3	DFNA5, POU4F3, MYO7A
regulation of multicellular organismal development (GO:2000026)	2.31	3	SIX1, GRHL2, KITLG
response to lipid (GO:0033993)	3.11	3	GJB6, GJB2, TNC
establishment of protein localization (GO:0045184)	2.53	3	MYH9, MYO6, MYO7A
system development (GO:0048731)	2.92	3	GJB2, SIX1, COL11A2
cation transmembrane transport (GO:0098655)	3.43	3	KCNQ4, P2RX2, TMC1
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	WFS1, SIX1, CRYM
regulation of phosphate metabolic process (GO:0019220)	2.35	2	WFS1, KITLG
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	WFS1, DFNA5
behavior (GO:0007610)	3.47	2	MYH14, P2RX2
muscle system process (GO:0003012)	4.18	2	MYH14, P2RX2
regulation of neuron apoptotic process (GO:0043523)	4.47	2	WFS1, SIX1
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	WFS1, SIX1
regulation of ion transmembrane transport (GO:0034765)	3.77	2	KCNQ4, DIAPH1
establishment of organelle localization (GO:0051656)	4.15	2	MYH9, MYO7A
cellular chemical homeostasis (GO:0055082)	3.4	2	WFS1, GJB6
regulation of transmembrane transport (GO:0034762)	3.74	2	KCNQ4, DIAPH1
single-organism catabolic process (GO:0044712)	3.21	2	COL11A2, CRYM
nitrogen compound transport (GO:0071705)	3.54	2	SLC17A8, CRYM
response to external biotic stimulus (GO:0043207)	3.13	2	COCH, GJB6
cellular macromolecule localization (GO:0070727)	3.1	2	SIX1, DIAPH1
anatomical structure homeostasis (GO:0060249)	4.25	2	ACTG1, COL11A2
skeletal muscle tissue development (GO:0007519)	5.65	2	MYH14, SIX1
kidney development (GO:0001822)	4.79	2	WFS1, SIX1
response to mechanical stimulus (GO:0009612)	4.41	2	TMC1, TNC
regulation of calcium ion transport into cytosol (GO:0010522)	5.23	2	P2RX2, DIAPH1
columnar/cuboidal epithelial cell differentiation (GO:0002065)	5.84	2	MYO7A, POU4F3
positive regulation of ion transport (GO:0043270)	4.36	2	WFS1, P2RX2
positive regulation of DNA metabolic process (GO:0051054)	4.49	2	GRHL2, KITLG
regulation of DNA metabolic process (GO:0051052)	3.87	2	GRHL2, KITLG
muscle contraction (GO:0006936)	4.37	2	MYH14, P2RX2
positive regulation of transport (GO:0051050)	2.9	2	WFS1, P2RX2
neuromuscular junction development (GO:0007528)	6.26	2	TNC, P2RX2
regulation of proteolysis (GO:0030162)	3.2	2	MYH9, DIABLO
multi-organism process (GO:0051704)	2.65	2	GJB2, COCH
vesicle-mediated transport (GO:0016192)	2.72	2	MYO6, MYO7A
single-organism behavior (GO:0044708)	3.79	2	MYH14, P2RX2
response to organonitrogen compound (GO:0010243)	3.2	2	P2RX2, DIAPH1
chemical homeostasis (GO:0048878)	2.97	2	WFS1, GJB6
immune system process (GO:0002376)	2.29	2	MYH9, ACTG1
extracellular matrix organization (GO:0030198)	4.01	2	TNC, COL11A2
cellular response to organic cyclic compound (GO:0071407)	3.93	2	TNC, DIAPH1
embryonic organ development (GO:0048568)	4.86	2	GRHL2, KITLG
neuron projection development (GO:0031175)	4.58	2	TNC, TBC1D24
phosphorus metabolic process (GO:0006793)	2.15	2	EYA4, KITLG
hair cell differentiation (GO:0035315)	7.02	2	MYO7A, POU4F3
cellular protein metabolic process (GO:0044267)	1.63	2	EYA4, KITLG
organic substance catabolic process (GO:1901575)	2.45	2	WFS1, CRYM
cell morphogenesis involved in differentiation (GO:0000904)	4.67	2	MYH9, GRHL2
positive regulation of transferase activity (GO:0051347)	3.31	2	GRHL2, KITLG
positive regulation of GTPase activity (GO:0043547)	3.28	2	TBC1D24, KITLG
neuron death (GO:0070997)	5.86	2	DIABLO, POU4F3
intracellular protein transport (GO:0006886)	3.2	2	MYO6, MYO7A
macromolecular complex assembly (GO:0065003)	2.55	2	P2RX2, DIAPH1
inorganic cation transmembrane transport (GO:0098662)	3.55	2	KCNQ4, TMC1
inorganic ion transmembrane transport (GO:0098660)	3.38	2	KCNQ4, TMC1
embryonic skeletal system morphogenesis (GO:0048704)	5.31	2	SIX1, GRHL2
single organism cell adhesion (GO:0098602)	3.63	2	MYH9, ACTG1
embryonic cranial skeleton morphogenesis (GO:0048701)	6.2	2	SIX1, GRHL2
cell-cell adhesion (GO:0098609)	3.34	2	MYH9, ACTG1
macromolecule modification (GO:0043412)	1.73	2	EYA4, KITLG
protein modification process (GO:0036211)	1.79	2	EYA4, KITLG
regulation of neuron death (GO:1901214)	4.19	2	WFS1, SIX1
negative regulation of neuron death (GO:1901215)	4.57	2	WFS1, SIX1
detection of stimulus (GO:0051606)	3.22	2	TMC1, P2RX2
brain development (GO:0007420)	4.24	2	SLC17A8, GRHL2
intracellular transport (GO:0046907)	2.67	2	MYO6, MYO7A
regulation of response to stress (GO:0080134)	2.53	2	WFS1, COCH
positive regulation of protein modification process (GO:0031401)	2.7	2	WFS1, KITLG
regulation of transferase activity (GO:0051338)	2.88	2	GRHL2, KITLG
regulation of cell motility (GO:2000145)	3.16	2	DIAPH1, KITLG
positive regulation of cell motility (GO:2000147)	3.74	2	DIAPH1, KITLG
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	WFS1, KITLG
synapse organization (GO:0050808)	4.87	2	TNC, P2RX2
tube formation (GO:0035148)	4.98	2	SIX1, GRHL2
cellular catabolic process (GO:0044248)	2.62	2	WFS1, CRYM
negative regulation of signaling (GO:0023057)	2.65	2	KCNQ4, WFS1
cell-cell junction assembly (GO:0007043)	5.42	2	GJB2, GRHL2
negative regulation of cell communication (GO:0010648)	2.66	2	KCNQ4, WFS1
ameboidal-type cell migration (GO:0001667)	4.71	2	MYH9, KITLG
regulation of GTPase activity (GO:0043087)	3.21	2	TBC1D24, KITLG
protein complex assembly (GO:0006461)	2.78	2	P2RX2, DIAPH1
regulation of protein localization (GO:0032880)	2.88	2	SIX1, MYO1A
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	SIX1, KITLG
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	SIX1, GRHL2
regulation of protein modification process (GO:0031399)	2.32	2	WFS1, KITLG
neuroepithelial cell differentiation (GO:0060563)	6.51	2	MYO7A, POU4F3
proteolysis (GO:0006508)	2.73	2	MYH9, WFS1
developmental growth involved in morphogenesis (GO:0060560)	5.15	2	TNC, POU4F3
monovalent inorganic cation transport (GO:0015672)	3.74	2	KCNQ4, SLC17A8
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	4.74	2	WFS1, DFNA5
cellular response to endogenous stimulus (GO:0071495)	3.33	2	TNC, DIAPH1
negative regulation of cell proliferation (GO:0008285)	3.26	2	GJB6, DFNA5
regulation of body fluid levels (GO:0050878)	3.76	2	WFS1, P2RX2
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	TNC, GJB6
epithelium development (GO:0060429)	4.57	2	SIX1, GRHL2
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	EYA4, MYO6
regulation of locomotion (GO:0040012)	3.12	2	DIAPH1, KITLG
cell-cell junction organization (GO:0045216)	4.66	2	GJB2, GRHL2
endocytosis (GO:0006897)	3.69	2	MYO6, MYO7A
tissue homeostasis (GO:0001894)	4.78	2	ACTG1, COL11A2
negative regulation of developmental process (GO:0051093)	3.17	2	SIX1, GRHL2
regulation of immune response (GO:0050776)	2.98	2	COCH, ACTG1
sensory organ development (GO:0007423)	4.82	2	SIX1, GRHL2
positive regulation of developmental process (GO:0051094)	2.77	2	SIX1, KITLG
response to hormone (GO:0009725)	3.33	2	GJB2, TNC
positive regulation of immune response (GO:0050778)	3.4	2	COCH, ACTG1
auditory receptor cell differentiation (GO:0042491)	7.53	2	MYO7A, POU4F3
protein localization to organelle (GO:0033365)	3.57	2	SIX1, DIAPH1
positive regulation of proteolysis (GO:0045862)	3.86	2	MYH9, DIABLO
response to nitrogen compound (GO:1901698)	3.12	2	P2RX2, DIAPH1
cellular homeostasis (GO:0019725)	3.23	2	WFS1, GJB6
single organismal cell-cell adhesion (GO:0016337)	3.69	2	MYH9, ACTG1
regulation of cellular localization (GO:0060341)	3.03	2	P2RX2, DIAPH1
apoptotic signaling pathway (GO:0097190)	4.12	2	DIABLO, KITLG
extrinsic apoptotic signaling pathway (GO:0097191)	5.16	2	DIABLO, KITLG
glucose homeostasis (GO:0042593)	4.6	2	WFS1, GJB6
striated muscle tissue development (GO:0014706)	5.23	2	MYH14, SIX1
positive regulation of cell death (GO:0010942)	3.32	2	DFNA5, DIABLO
morphogenesis of an epithelium (GO:0002009)	4.08	2	SIX1, TNC
regulation of growth (GO:0040008)	3.26	2	WFS1, SIX1
carbohydrate homeostasis (GO:0033500)	4.6	2	WFS1, GJB6
positive regulation of apoptotic process (GO:0043065)	3.38	2	DFNA5, DIABLO
tissue morphogenesis (GO:0048729)	3.87	2	SIX1, TNC
extracellular structure organization (GO:0043062)	4.0	2	TNC, COL11A2
hematopoietic or lymphoid organ development (GO:0048534)	4.49	2	SIX1, KITLG
positive regulation of programmed cell death (GO:0043068)	3.38	2	DFNA5, DIABLO
neuron development (GO:0048666)	4.8	2	TMC1, MYO7A
positive regulation of cell migration (GO:0030335)	3.77	2	DIAPH1, KITLG
regulation of cell migration (GO:0030334)	3.23	2	DIAPH1, KITLG
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	WFS1, KITLG
homotypic cell-cell adhesion (GO:0034109)	5.76	2	MYH9, ACTG1
cellular protein localization (GO:0034613)	3.11	2	SIX1, DIAPH1
cellular protein modification process (GO:0006464)	1.79	2	EYA4, KITLG
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	WFS1, KITLG
neuron apoptotic process (GO:0051402)	6.15	2	DIABLO, POU4F3
vesicle localization (GO:0051648)	4.85	2	MYO1A, MYO7A
tube development (GO:0035295)	4.41	2	SIX1, GRHL2
cell morphogenesis (GO:0000902)	4.35	2	MYH9, GRHL2
positive regulation of cellular component movement (GO:0051272)	3.71	2	DIAPH1, KITLG
regulation of cellular component movement (GO:0051270)	3.08	2	DIAPH1, KITLG
response to carbohydrate (GO:0009743)	4.62	2	GJB6, P2RX2
positive regulation of locomotion (GO:0040017)	3.71	2	DIAPH1, KITLG
positive regulation of calcium ion transport (GO:0051928)	5.06	2	WFS1, P2RX2
epidermal cell differentiation (GO:0009913)	5.13	2	MYO7A, POU4F3
regulation of cellular component biogenesis (GO:0044087)	3.08	2	SIX1, TBC1D24
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	EYA4, KITLG
regulation of ion homeostasis (GO:2000021)	4.44	2	P2RX2, DIAPH1
muscle tissue development (GO:0060537)	5.1	2	MYH14, SIX1
single-organism cellular localization (GO:1902580)	3.16	2	MYH9, MYO7A
platelet aggregation (GO:0070527)	6.04	2	MYH9, ACTG1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
developmental process (GO:0032502)	-	1.36	0.013	GRHL2, DFNA5, MYO6, COL11A2, GJB3, TMC1, GJB6, MYH14, POU4F3, GJB2, TNC, KCNQ4, KITLG, WFS1, MYO7A, P2RX2, EYA4, SIX1, MYH9
embryonic morphogenesis (GO:0048598)	-	3.72	0.014	GRHL2, MYO6, EYA4, SIX1, MYH9, POU4F3, TNC, KCNQ4, MYO7A, GJB2, GJB6
inner ear morphogenesis (GO:0042472)	-	5.62	0.001	TNC, MYO6, SIX1, POU4F3, KCNQ4, MYO7A
single-multicellular organism process (GO:0044707)	-	1.78	0.0	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, GRHL2, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, SIX1
actin filament-based movement (GO:0030048)	-	5.54	0.003	MYH14, MYO6, MYH9, MYO7A
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.004	GRHL2, MYO6, SIX1, MYH14, POU4F3, TNC, KCNQ4, MYO7A, EYA4, GJB6, MYH9
sensory perception of mechanical stimulus (GO:0050954)	-	4.79	0.0	SLC17A8, DFNA5, COL11A2, DIAPH1, EYA4, GJB6, MYO6, MYO1A, CEACAM16, GJB2, KCNQ4, MYH14, WFS1, CRYM, TECTA, MYO7A, P2RX2, GJB3, POU4F3, COCH, SIX1
multicellular organismal process (GO:0032501)	-	1.45	0.0	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, GRHL2, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, SIX1
anatomical structure development (GO:0048856)	-	1.58	0.0	GRHL2, TNC, P2RX2, MYO6, COL11A2, EYA4, SIX1, MYH14, POU4F3, GJB6, MYH9, KITLG, WFS1, TMC1, MYO7A, GJB3, GJB2
sensory perception (GO:0007600)	-	2.93	0.0	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, COL11A2, MYO6, SIX1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, ACTG1, CEACAM16, KCNQ4, GJB2, GJB6
mechanoreceptor differentiation (GO:0042490)	-	6.78	0.003	MYO6, DFNA5, MYO7A, POU4F3
single-organism developmental process (GO:0044767)	-	1.49	0.016	GRHL2, DFNA5, KITLG, MYO6, EYA4, GJB3, TMC1, WFS1, POU4F3, KCNQ4, TNC, MYH14, SIX1, MYO7A, P2RX2, GJB2, GJB6, MYH9
sensory perception of sound (GO:0007605)	-	4.82	0.0	SLC17A8, P2RX2, DIAPH1, COL11A2, EYA4, SIX1, MYO6, MYO1A, CEACAM16, GJB2, KCNQ4, WFS1, CRYM, TECTA, MYH14, DFNA5, GJB3, POU4F3, COCH, GJB6, MYO7A
regulation of cell shape (GO:0008360)	-	4.77	0.034	MYH9, COCH, MYH14, DIAPH1
neurological system process (GO:0050877)	-	2.64	0.0	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYH9, MYO1A, GJB3, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, ACTG1, CEACAM16, KCNQ4, GJB2, TNC, GJB6, SIX1
inner ear receptor cell differentiation (GO:0060113)	-	7.02	0.002	MYO6, DFNA5, MYO7A, POU4F3
system process (GO:0003008)	-	2.3	0.0	EYA4, DFNA5, MYO7A, DIAPH1, COCH, CRYM, MYO1A, GJB3, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, SLC17A8, P2RX2, CEACAM16, KCNQ4, GJB2, GJB6, SIX1
single-organism process (GO:0044699)	-	0.48	0.001	EYA4, DFNA5, MYO7A, DIAPH1, SLC17A8, CRYM, MYH9, MYO1A, GJB3, GRHL2, COL11A2, MYO6, TMC1, POU4F3, MYH14, WFS1, TECTA, KITLG, TBC1D24, DIABLO, COCH, P2RX2, ACTG1, CEACAM16, KCNQ4, GJB2, TNC, GJB6, HOMER2, SIX1, OSBPL2
hair cell differentiation (GO:0035315)	-	7.02	0.042	MYO6, MYO7A, POU4F3

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	29	EYA4, DFNA5, MYO7A, DIAPH1, WFS1, CRYM, MYH9, MYO1A, GJB3, GRHL2, COL11A2, MYO6, SIX1, POU4F3, MYH14, TECTA, KITLG, TBC1D24, DIABLO, SLC17A8, P2RX2, CCDC50, ACTG1, CEACAM16, KCNQ4, GJB2, GJB6, HOMER2, TMC1
intracellular part (GO:0044424)	0.28	26	EYA4, DFNA5, MYO7A, DIAPH1, WFS1, CRYM, MYH9, MYO1A, GJB3, GRHL2, COL11A2, MYO6, SIX1, POU4F3, MYH14, KITLG, TBC1D24, DIABLO, SLC17A8, P2RX2, CCDC50, ACTG1, KCNQ4, GJB2, GJB6, HOMER2
membrane (GO:0016020)	0.68	21	DIAPH1, SLC17A8, P2RX2, TECTA, MYO6, GJB3, TMC1, ACTG1, GRHL2, KCNQ4, TNC, MYH14, KITLG, WFS1, DIABLO, HOMER2, MYO7A, MYO1A, GJB2, GJB6, MYH9
organelle (GO:0043226)	0.4	21	DIAPH1, SLC17A8, MYO6, COL11A2, GRHL2, HOMER2, SIX1, EYA4, ACTG1, MYH14, POU4F3, MYH9, KITLG, WFS1, CRYM, TECTA, DIABLO, GJB2, COCH, MYO1A, MYO7A
cytoplasm (GO:0005737)	1.01	20	DIAPH1, SLC17A8, DFNA5, KITLG, MYO6, EYA4, HOMER2, CCDC50, ACTG1, MYH14, CRYM, KCNQ4, DIABLO, MYO1A, MYO7A, GJB3, GJB2, TBC1D24, SIX1, MYH9
organelle part (GO:0044422)	0.79	19	DIAPH1, SLC17A8, P2RX2, MYO6, COL11A2, HOMER2, SIX1, ACTG1, GRHL2, CEACAM16, MYH9, WFS1, CRYM, MYO1A, MYH14, MYO7A, POU4F3, TMC1, DIABLO
intracellular organelle (GO:0043229)	0.51	18	DIAPH1, SLC17A8, MYO6, COL11A2, EYA4, HOMER2, SIX1, ACTG1, GRHL2, CRYM, MYH9, KITLG, WFS1, POU4F3, MYO1A, MYO7A, GJB2, DIABLO
intracellular organelle part (GO:0044446)	0.81	17	SLC17A8, GRHL2, P2RX2, DIAPH1, COL11A2, HOMER2, SIX1, MYO6, ACTG1, MYH14, CRYM, MYH9, WFS1, POU4F3, MYO1A, MYO7A, DIABLO
membrane part (GO:0044425)	0.95	17	SLC17A8, TMC1, P2RX2, HOMER2, DIAPH1, GJB6, MYO6, MYO1A, KCNQ4, MYH9, KITLG, WFS1, TECTA, MYO7A, GJB2, GJB3, DIABLO
membrane-bounded organelle (GO:0043227)	0.47	17	SLC17A8, HOMER2, MYO6, GRHL2, SIX1, EYA4, ACTG1, MYH14, CRYM, MYH9, WFS1, POU4F3, TECTA, MYO7A, GJB2, COCH, DIABLO
protein complex (GO:0043234)	1.51	15	WFS1, P2RX2, MYO6, COL11A2, SIX1, ACTG1, MYH14, KCNQ4, GJB6, MYH9, MYO1A, MYO7A, GJB3, GJB2, DIABLO
macromolecular complex (GO:0032991)	1.35	15	WFS1, P2RX2, COL11A2, MYO6, GJB3, GJB6, ACTG1, MYH9, KCNQ4, MYO1A, MYH14, GJB2, SIX1, DIABLO, MYO7A
cytoplasmic part (GO:0044444)	0.82	14	DIAPH1, SLC17A8, COL11A2, MYO6, GJB6, ACTG1, MYH14, CRYM, MYH9, WFS1, MYO1A, MYO7A, GJB2, DIABLO
intracellular membrane-bounded organelle (GO:0043231)	0.6	14	SLC17A8, HOMER2, MYO6, EYA4, SIX1, ACTG1, GRHL2, CRYM, MYH9, WFS1, POU4F3, MYO7A, GJB2, DIABLO
plasma membrane part (GO:0044459)	1.95	13	DIAPH1, MYO7A, P2RX2, HOMER2, MYO6, GJB3, TMC1, MYH9, KCNQ4, MYO1A, GJB2, GJB6, DIABLO
plasma membrane (GO:0005886)	1.39	13	GRHL2, P2RX2, MYO6, DIAPH1, GJB6, ACTG1, KCNQ4, MYH9, KITLG, HOMER2, TECTA, GJB3, GJB2
extracellular region part (GO:0044421)	1.57	11	TNC, COL11A2, MYO6, ACTG1, MYH14, CRYM, MYH9, CEACAM16, TECTA, KITLG, COCH
intrinsic component of membrane (GO:0031224)	1.13	11	WFS1, P2RX2, KITLG, GJB3, TMC1, SLC17A8, KCNQ4, TECTA, GJB2, GJB6, DIABLO
neuron part (GO:0097458)	2.64	10	SLC17A8, WFS1, HOMER2, TMC1, MYH14, CEACAM16, KCNQ4, MYO1A, MYO7A, TBC1D24
integral component of membrane (GO:0016021)	1.14	10	SLC17A8, P2RX2, KITLG, GJB6, WFS1, KCNQ4, GJB3, GJB2, TMC1, DIABLO
cell projection (GO:0042995)	2.47	10	SLC17A8, DIAPH1, MYO6, MYH9, KCNQ4, WFS1, HOMER2, MYH14, MYO7A, MYO1A
cell projection part (GO:0044463)	2.97	10	DIAPH1, SLC17A8, HOMER2, MYO6, TMC1, CEACAM16, MYH14, MYO1A, MYO7A, TBC1D24
vesicle (GO:0031982)	1.64	9	SLC17A8, MYO7A, MYO6, ACTG1, MYH14, CRYM, MYH9, TECTA, COCH
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	9	DIAPH1, COL11A2, KITLG, SIX1, ACTG1, MYH9, HOMER2, MYO1A, MYO7A
nucleus (GO:0005634)	1.07	9	GRHL2, MYO6, SIX1, ACTG1, EYA4, CRYM, MYH9, POU4F3, HOMER2
membrane-bounded vesicle (GO:0031988)	1.71	9	SLC17A8, MYO7A, MYO6, ACTG1, MYH14, CRYM, MYH9, TECTA, COCH
non-membrane-bounded organelle (GO:0043228)	1.76	9	MYO7A, DIAPH1, COL11A2, SIX1, ACTG1, MYH9, HOMER2, MYO1A, KITLG
cell junction (GO:0030054)	2.75	9	SLC17A8, GJB6, ACTG1, GRHL2, TNC, MYH9, HOMER2, GJB2, GJB3
plasma membrane region (GO:0098590)	2.97	8	P2RX2, DIAPH1, MYO6, GJB6, KCNQ4, HOMER2, MYO1A, MYO7A
cytosol (GO:0005829)	1.68	8	DIAPH1, MYO6, GJB6, ACTG1, MYH9, MYH14, MYO7A, DIABLO
nuclear part (GO:0044428)	1.55	7	GRHL2, P2RX2, MYO6, SIX1, POU4F3, MYH9, HOMER2
cytoskeletal part (GO:0044430)	2.49	7	DIAPH1, MYO6, ACTG1, MYH9, MYH14, MYO1A, MYO7A
extracellular organelle (GO:0043230)	1.89	7	COCH, MYO6, ACTG1, MYH9, CRYM, MYH14, TECTA
extracellular exosome (GO:0070062)	1.89	7	COCH, MYO6, ACTG1, MYH9, CRYM, MYH14, TECTA
extracellular vesicle (GO:1903561)	1.89	7	COCH, MYO6, ACTG1, MYH9, CRYM, MYH14, TECTA
cytoskeleton (GO:0005856)	2.55	6	KITLG, DIAPH1, ACTG1, MYH9, MYO1A, MYO7A
plasma membrane protein complex (GO:0098797)	3.55	6	GJB6, MYH9, KCNQ4, GJB2, GJB3, DIABLO
extracellular region (GO:0005576)	2.18	6	COCH, COL11A2, KITLG, TNC, CEACAM16, TECTA
neuron projection (GO:0043005)	3.12	6	SLC17A8, HOMER2, WFS1, KCNQ4, MYO1A, MYH14
membrane protein complex (GO:0098796)	2.84	6	GJB6, MYH9, KCNQ4, GJB2, GJB3, DIABLO
myosin complex (GO:0016459)	5.55	5	MYO1A, MYH9, MYO6, MYH14, MYO7A
synapse (GO:0045202)	3.58	5	HOMER2, SLC17A8, TBC1D24, MYH9, MYO7A
cell-cell junction (GO:0005911)	3.85	5	GJB6, MYH9, GJB2, GJB3, GRHL2
apical plasma membrane (GO:0016324)	4.13	4	GJB6, P2RX2, MYO1A, MYO7A
proteinaceous extracellular matrix (GO:0005578)	4.01	4	TNC, COCH, COL11A2, TECTA
actin-based cell projection (GO:0098858)	4.83	4	MYO1A, MYO6, MYO7A, HOMER2
extracellular space (GO:0005615)	2.63	4	TNC, ACTG1, CEACAM16, KITLG
extracellular matrix (GO:0031012)	3.81	4	TNC, COCH, COL11A2, TECTA
actin cytoskeleton (GO:0015629)	4.39	3	MYH9, ACTG1, MYO1A
cell-substrate junction (GO:0030055)	3.82	3	MYH9, ACTG1, TNC
membrane-enclosed lumen (GO:0031974)	3.05	3	COL11A2, DIABLO, CRYM
microvillus (GO:0005902)	5.69	3	MYO1A, MYO6, MYO7A
brush border (GO:0005903)	5.68	3	MYH9, MYH14, MYO1A
dendrite (GO:0030425)	3.92	3	WFS1, SLC17A8, HOMER2
focal adhesion (GO:0005925)	3.83	3	MYH9, ACTG1, TNC
connexon complex (GO:0005922)	6.71	3	GJB6, GJB3, GJB2
cell-substrate adherens junction (GO:0005924)	3.83	3	MYH9, ACTG1, TNC
gap junction (GO:0005921)	6.34	3	GJB6, GJB3, GJB2
organelle membrane (GO:0031090)	1.97	3	SLC17A8, MYO6, MYO7A
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	SLC17A8, MYO6, MYO7A
cytoplasmic vesicle (GO:0031410)	2.87	3	SLC17A8, MYO6, MYO7A
whole membrane (GO:0098805)	2.85	3	SLC17A8, MYO6, MYO7A
nucleoplasm (GO:0005654)	1.89	3	GRHL2, MYO6, POU4F3
synapse part (GO:0044456)	3.42	3	SLC17A8, TBC1D24, HOMER2
cluster of actin-based cell projections (GO:0098862)	5.54	3	MYH9, MYH14, MYO1A
neuronal cell body (GO:0043025)	3.9	3	SLC17A8, MYO1A, HOMER2
filamentous actin (GO:0031941)	6.76	3	ACTG1, MYO6, MYO1A
cytoplasmic region (GO:0099568)	4.51	3	MYH9, MYO6, MYO7A
adherens junction (GO:0005912)	3.66	3	MYH9, ACTG1, TNC
stereocilium tip (GO:0032426)	7.61	3	TMC1, HOMER2, CEACAM16
bounding membrane of organelle (GO:0098588)	2.39	3	SLC17A8, MYO6, MYO7A
anchoring junction (GO:0070161)	3.61	3	MYH9, ACTG1, TNC
cell body (GO:0044297)	3.74	3	SLC17A8, MYO1A, HOMER2
cell cortex (GO:0005938)	4.78	3	MYH9, MYO6, MYO7A
receptor complex (GO:0043235)	4.01	3	MYH9, P2RX2, DIABLO
organelle lumen (GO:0043233)	3.05	3	COL11A2, DIABLO, CRYM
intracellular organelle lumen (GO:0070013)	3.05	3	COL11A2, DIABLO, CRYM
intracellular vesicle (GO:0097708)	2.86	3	SLC17A8, MYO6, MYO7A
actin filament bundle (GO:0032432)	5.74	2	MYH9, MYH14
site of polarized growth (GO:0030427)	4.85	2	MYH14, MYO1A
growth cone (GO:0030426)	4.89	2	MYH14, MYO1A
neuromuscular junction (GO:0031594)	5.81	2	MYH9, TBC1D24
side of membrane (GO:0098552)	4.22	2	TMC1, DIABLO
contractile actin filament bundle (GO:0097517)	5.81	2	MYH9, MYH14
actomyosin (GO:0042641)	5.66	2	MYH9, MYH14
stress fiber (GO:0001725)	5.81	2	MYH9, MYH14
ruffle (GO:0001726)	5.28	2	MYH9, MYO6
spindle (GO:0005819)	4.52	2	MYH9, DIAPH1
myosin filament (GO:0032982)	6.71	2	MYH9, MYH14
nucleolus (GO:0005730)	3.06	2	SIX1, HOMER2
myelin sheath (GO:0043209)	4.76	2	MYH14, ACTG1
myosin II filament (GO:0097513)	8.7	2	MYH9, MYH14
plasma membrane receptor complex (GO:0098802)	4.63	2	MYH9, DIABLO
mitochondrion (GO:0005739)	2.42	2	DIABLO, CRYM
vacuolar membrane (GO:0005774)	3.45	2	MYO6, MYO7A
cytoplasmic vesicle part (GO:0044433)	3.41	2	SLC17A8, MYO6
endoplasmic reticulum part (GO:0044432)	2.73	2	WFS1, COL11A2
vacuolar part (GO:0044437)	3.26	2	MYO6, MYO7A
basal plasma membrane (GO:0009925)	6.34	2	KCNQ4, MYO1A
stereocilium (GO:0032420)	6.4	2	MYO7A, HOMER2
lateral plasma membrane (GO:0016328)	5.89	2	GJB2, MYO1A
leading edge membrane (GO:0031256)	4.9	2	MYO6, DIAPH1
membrane region (GO:0098589)	3.95	2	MYO1A, MYO6
cell projection membrane (GO:0031253)	4.11	2	DIAPH1, MYO6
cell leading edge (GO:0031252)	6.04	2	MYH9, MYO1A
cytoplasmic vesicle membrane (GO:0030659)	3.67	2	SLC17A8, MYO6
vesicle membrane (GO:0012506)	3.63	2	SLC17A8, MYO6
ruffle membrane (GO:0032587)	5.42	2	MYO6, DIAPH1
cortical cytoskeleton (GO:0030863)	5.58	2	MYH9, MYO1A
lysosomal membrane (GO:0005765)	4.19	2	MYO6, MYO7A
unconventional myosin complex (GO:0016461)	7.72	2	MYO6, MYO7A
myosin II complex (GO:0016460)	6.54	2	MYH9, MYH14
cell cortex part (GO:0044448)	5.01	2	MYH9, MYO1A
axon part (GO:0033267)	4.4	2	SLC17A8, TBC1D24
extracellular matrix component (GO:0044420)	4.97	2	TNC, COL11A2
lytic vacuole membrane (GO:0098852)	4.19	2	MYO6, MYO7A

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
myosin complex (GO:0016459)	-	5.55	0.0	MYO1A, MYH9, MYO6, MYH14, MYO7A
filamentous actin (GO:0031941)	-	6.76	0.002	ACTG1, MYO1A, MYO6
stereocilium bundle tip (GO:0032426)	-	7.61	0.017	TMC1, CEACAM16
apical plasma membrane (GO:0016324)	-	4.13	0.044	P2RX2, MYO7A, MYO6, GJB6, ACTG1, MYH9, MYO1A
plasma membrane part (GO:0044459)	-	1.95	0.004	DIAPH1, MYO7A, P2RX2, HOMER2, MYO6, TMC1, KCNQ4, GJB6, MYH9, MYO1A, GJB2, GJB3, DIABLO
myosin II filament (GO:0097513)	-	8.7	0.001	MYH9, MYH14
unconventional myosin complex (GO:0016461)	-	7.72	0.017	MYO6, MYO7A
myofibril (GO:0030016)	NEW	6.14	0.036	MYH9, ACTG1, MYO6
microvillus (GO:0005902)	-	5.69	0.028	MYO1A, MYO6, MYO7A
brush border (GO:0005903)	-	5.68	0.017	ACTG1, MYO6, MYO1A
cell projection (GO:0042995)	-	2.47	0.009	SLC17A8, P2RX2, MYO1A, MYO6, WFS1, MYH9, HOMER2, MYH14, MYO7A
connexon complex (GO:0005922)	-	6.71	0.001	GJB6, GJB3, GJB2