Disease table of DEAFNESS, AUTOSOMAL RECESSIVE OMIM ID: PS220290

Gene-disease associations table

Gene	Associated with DEAFNESS, AUTOSOMAL RECESSIVE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
MYO3A	ClinVar, OMIM	HGNC link	10p12.1	1	PS220290
KARS	ClinVar, OMIM, HUMSAVAR	HGNC link	16q23.1	2	PS118220, PS220290
PTPRQ	ClinVar, OMIM, HUMSAVAR	HGNC link	12q21.31	1	PS220290
TMC1	ClinVar, OMIM, HUMSAVAR	HGNC link	9q21.13	2	PS220290, PS124900
COL11A2	ClinVar, OMIM, HUMSAVAR	HGNC link	6p21.32	6	PS108300, PS220290, 215150, 277610, PS124900, PS228520
PNPT1	ClinVar, OMIM, HUMSAVAR	HGNC link	2p16.1	2	PS609060, PS220290
TMPRSS3	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.3	1	PS220290
TMIE	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	1	PS220290
LOXHD1	ClinVar, OMIM	HGNC link	18q21.1	1	PS220290
KCNJ10	ClinVar, OMIM	HGNC link	1q23.2	2	PS220290, 612780
WHRN	ClinVar, OMIM	HGNC link	9q32	2	PS220290, PS276900
EPS8	ClinVar, OMIM	HGNC link	12p12.3	1	PS220290
FOXI1	ClinVar, OMIM	HGNC link	5q35.1	2	274600, PS220290
LHFPL5	ClinVar, OMIM, HUMSAVAR	HGNC link	6p21.31	1	PS220290
MYO6	ClinVar, OMIM, HUMSAVAR	HGNC link	6q14.1	2	PS220290, PS124900
GIPC3	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.3	1	PS220290
ESPN	OMIM, HUMSAVAR	HGNC link	1p36.31	1	PS220290
TSPEAR	OMIM	HGNC link	21q22.3	1	PS220290
S1PR2	ClinVar, OMIM	HGNC link	19p13.2	1	PS220290
GJB3	OMIM	HGNC link	1p34.3	3	133200, PS124900, PS220290
GJB2	ClinVar, OMIM, HUMSAVAR	HGNC link	13q12.11	7	124500, PS220290, 148210, PS124900, 602540, 148350, 149200
GJB6	ClinVar, OMIM	HGNC link	13q12.11	3	PS220290, PS305100, PS124900
CIB2	ClinVar, OMIM, HUMSAVAR	HGNC link	15q25.1	2	PS220290, PS276900
OTOGL	ClinVar, OMIM	HGNC link	12q21.31	1	PS220290
TBC1D24	ClinVar, OMIM, HUMSAVAR	HGNC link	16p13.3	6	PS220290, 605021, PS124900, PS308350, PS254800, 220500
USH1C	ClinVar, OMIM	HGNC link	11p15.1	2	PS220290, PS276900
DCDC2	ClinVar, OMIM, HUMSAVAR	HGNC link	6p22.3	2	PS220290, PS256100
TECTA	OMIM	HGNC link	11q23.3	2	PS220290, PS124900
CLIC5	ClinVar, OMIM	HGNC link	6p21.1	1	PS220290
ESRRB	ClinVar, OMIM, HUMSAVAR	HGNC link	14q24.3	1	PS220290
ILDR1	ClinVar, OMIM, HUMSAVAR	HGNC link	3q13.33	1	PS220290
TPRN	ClinVar, OMIM	HGNC link	9q34.3	1	PS220290
FAM65B	ClinVar, OMIM	HGNC link	6p22.3	1	PS220290
CDH23	ClinVar, OMIM, HUMSAVAR	HGNC link	10q22.1	2	PS220290, PS276900
LRTOMT	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.4	1	PS220290
GRXCR1	ClinVar, OMIM, HUMSAVAR	HGNC link	4p13	1	PS220290
GRXCR2	ClinVar, OMIM	HGNC link	5q32	1	PS220290
RDX	ClinVar, OMIM, HUMSAVAR	HGNC link	11q22.3	1	PS220290
ELMOD3	ClinVar, OMIM, HUMSAVAR	HGNC link	2p11.2	1	PS220290
SLC26A4	ClinVar, OMIM, HUMSAVAR	HGNC link	7q22.3	2	274600, PS220290
MSRB3	ClinVar, OMIM, HUMSAVAR	HGNC link	12q14.3	1	PS220290
DFNB59	ClinVar, OMIM, HUMSAVAR	HGNC link	2q31.2	1	PS220290
HGF	ClinVar, OMIM	HGNC link	7q21.11	1	PS220290
MARVELD2	ClinVar, OMIM	HGNC link	5q13.2	1	PS220290
ATP2B2	OMIM	HGNC link	3p25.3	1	PS220290
SYNE4	OMIM	HGNC link	19q13.12	1	PS220290
SERPINB6	ClinVar, OMIM	HGNC link	6p25.2	1	PS220290
ADCY1	ClinVar, OMIM	HGNC link	7p12.3	1	PS220290
TRIOBP	ClinVar, OMIM, HUMSAVAR	HGNC link	22q13.1	1	PS220290
OTOA	ClinVar, OMIM	HGNC link	16p12.2	1	PS220290
CABP2	ClinVar, OMIM	HGNC link	11q13.2	1	PS220290
OTOF	ClinVar, OMIM, HUMSAVAR	HGNC link	2p23.3	2	PS609129, PS220290
OTOG	ClinVar, OMIM, HUMSAVAR	HGNC link	11p15.1	1	PS220290
MET	ClinVar, OMIM, HUMSAVAR	HGNC link	7q31.2	6	114550, 607278, PS209850, 605074, PS220290, 142340
CLDN14	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.13	1	PS220290
PCDH15	ClinVar, OMIM, HUMSAVAR	HGNC link	10q21.1	2	PS220290, PS276900
STRC	ClinVar, OMIM	HGNC link	15q15.3	1	PS220290
MYO15A	ClinVar, OMIM, HUMSAVAR	HGNC link	17p11.2	1	PS220290
MYO7A	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.5	4	PS124900, PS220290, PS268000, PS276900
SLC26A5	ClinVar, OMIM	HGNC link	7q22.1	1	PS220290

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 355	2	SLC26A4, SLC26A5
Group 595	2	GJB6, GJB2

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
11p15.1	2	USH1C, OTOG
13q12.11	2	GJB6, GJB2
6p22.3	2	DCDC2, FAM65B
12q21.31	2	PTPRQ, OTOGL
21q22.3	2	TSPEAR, TMPRSS3

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
7q22	2	SLC26A4, SLC26A5
13q12	2	GJB6, GJB2
12q21	2	PTPRQ, OTOGL
21q22	3	TSPEAR, CLDN14, TMPRSS3
19p13	2	GIPC3, S1PR2
11p15	2	USH1C, OTOG
11q13	3	LRTOMT, MYO7A, CABP2
6p21	3	LHFPL5, CLIC5, COL11A2
6p22	2	DCDC2, FAM65B

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12q2	2	PTPRQ, OTOGL
2p1	2	PNPT1, ELMOD3
13q1	2	GJB6, GJB2
3p2	2	ATP2B2, TMIE
7q2	3	HGF, SLC26A4, SLC26A5
1p3	2	GJB3, ESPN
16p1	2	TBC1D24, OTOA
11p1	2	USH1C, OTOG
6p2	6	COL11A2, DCDC2, SERPINB6, CLIC5, LHFPL5, FAM65B
5q3	2	GRXCR2, FOXI1
19p1	2	GIPC3, S1PR2
11q1	3	LRTOMT, MYO7A, CABP2
11q2	2	TECTA, RDX
10q2	2	CDH23, PCDH15
21q2	3	TSPEAR, CLDN14, TMPRSS3
9q3	2	WHRN, TPRN

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
12q	3	PTPRQ, OTOGL, MSRB3
7q	4	HGF, SLC26A4, SLC26A5, MET
9q	3	WHRN, TPRN, TMC1
10q	2	CDH23, PCDH15
16p	2	TBC1D24, OTOA
1p	2	GJB3, ESPN
3p	2	ATP2B2, TMIE
5q	3	MARVELD2, GRXCR2, FOXI1
15q	2	CIB2, STRC
21q	3	TSPEAR, CLDN14, TMPRSS3
19p	2	GIPC3, S1PR2
6p	6	COL11A2, DCDC2, SERPINB6, CLIC5, LHFPL5, FAM65B
13q	2	GJB6, GJB2
11q	5	LRTOMT, MYO7A, TECTA, CABP2, RDX
11p	2	USH1C, OTOG
2p	3	PNPT1, OTOF, ELMOD3

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	7	RDX, USH1C, OTOG, CABP2, LRTOMT, TECTA, MYO7A
10	3	PCDH15, CDH23, MYO3A
13	2	GJB6, GJB2
12	4	PTPRQ, EPS8, MSRB3, OTOGL
15	2	CIB2, STRC
21	3	TSPEAR, CLDN14, TMPRSS3
16	3	KARS, TBC1D24, OTOA
19	3	SYNE4, GIPC3, S1PR2
1	3	KCNJ10, GJB3, ESPN
3	3	ATP2B2, ILDR1, TMIE
2	4	PNPT1, DFNB59, ELMOD3, OTOF
5	3	MARVELD2, GRXCR2, FOXI1
7	5	HGF, SLC26A5, SLC26A4, MET, ADCY1
6	7	COL11A2, MYO6, DCDC2, SERPINB6, CLIC5, LHFPL5, FAM65B
9	3	WHRN, TPRN, TMC1

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	3	MET, COL11A2, HGF
SP3	NO	109	DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC6	3	MET, COL11A2, HGF

regulated gene	associated to this disease	# TFs	TFs
COL11A2	YES	7	SP1, SP7, SOX9, ERG, SP3, EWSR1, SOX10
DCDC2	YES	1	EHF
RDX	YES	1	CREB5
HGF	YES	5	SP1, SP3, STAT3, TFAP2A, NFIC
MET	YES	13	SP1, FOXP2, PAX3, SMAD7, TP53, SNAI2, HIF1A, MITF, SP3, YBX1, PAX5, PAX6, STAT1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
MYO3A	KARS	No	1	MCM2
MYO3A	SERPINB6	No	1	MCM2
KARS	TMC1	No	2	COPS5, CAND1
KARS	PNPT1	No	3	NTRK1, SIRT7, ICT1
KARS	EPS8	No	1	AIMP2
KARS	MYO6	No	4	NTRK1, ABCE1, ESR1, FBXO6
KARS	USH1C	No	1	UBA1
KARS	CLIC5	No	1	FN1
KARS	ESRRB	No	2	SLC25A6, GAPDH
KARS	CDH23	No	1	PPME1
KARS	RDX	No	3	NTRK1, HSPA4, ESR1
KARS	MSRB3	No	1	GAPDH
KARS	HGF	No	1	FN1
KARS	SERPINB6	No	2	NTRK1, MCM2
KARS	TRIOBP	No	1	VIM
KARS	MET	No	2	HSPA4, FBXO6
PNPT1	MYO6	No	3	NTRK1, NXF1, CLTB
PNPT1	RDX	No	2	NTRK1, NCL
PNPT1	MSRB3	No	1	NXF1
PNPT1	MARVELD2	No	1	NXF1
PNPT1	SERPINB6	No	1	NTRK1
TMPRSS3	ESRRB	No	1	EEF1A1
TMPRSS3	TRIOBP	No	1	KIF2A
KCNJ10	FOXI1	No	1	APP
KCNJ10	DCDC2	No	1	APP
KCNJ10	ESRRB	No	1	HSPA8
KCNJ10	ATP2B2	No	1	SNTA1
KCNJ10	SYNE4	No	1	SEC23B
EPS8	MYO6	No	1	CFTR
EPS8	CLIC5	No	1	TPRN
EPS8	ESRRB	No	2	GRB2, EGFR
EPS8	TPRN	Yes	1	EPS8
EPS8	SYNE4	No	1	CSNK2B
EPS8	TRIOBP	No	1	C17ORF59
EPS8	MET	No	6	CBL, SOS1, EGFR, SRC, GRB2, SHC1
EPS8	MYO15A	Yes	1	EPS8
FOXI1	DCDC2	No	1	APP
MYO6	GIPC3	No	2	MOV10, ENO1
MYO6	ESRRB	No	2	SP1, PARK2
MYO6	TPRN	No	16	MYO1C, MYO19, CALML3, ITGA5, ANLN, ACTB, CAPZA2, PPP1CB, MYH9, TPM1, MYO18A, MYO5C, MYH10, FLNA, SYNPO, DBN1
MYO6	RDX	No	3	NTRK1, ESR1, ENO1
MYO6	MSRB3	No	2	NXF1, MOV10
MYO6	MARVELD2	No	2	NXF1, MOV10
MYO6	SERPINB6	No	1	NTRK1
MYO6	TRIOBP	No	6	ANLN, CAPZA2, PPP1CB, ACTB, MYO18A, MYH9
MYO6	OTOG	No	1	UBC
MYO6	MET	No	2	FBXO6, CDH1
MYO6	MYO7A	No	1	CDH1
GIPC3	RDX	No	1	ENO1
GIPC3	MSRB3	No	1	MOV10
GIPC3	MARVELD2	No	1	MOV10
GJB3	GJB2	No	1	CNST
GJB3	GJB6	No	1	CNST
GJB3	LRTOMT	No	1	ELAVL1
GJB3	RDX	No	1	ELAVL1
GJB3	MARVELD2	No	1	ELAVL1
GJB3	TRIOBP	No	1	ELAVL1
GJB2	GJB6	No	1	CNST
GJB2	ESRRB	No	1	TFRC
USH1C	CDH23	Yes	1	USH1C
USH1C	MYO7A	Yes	1	USH1C
CLIC5	TPRN	Yes	1	CLIC4
CLIC5	RDX	No	1	EZR
CLIC5	HGF	No	1	FN1
ESRRB	RDX	No	1	HNRNPF
ESRRB	MSRB3	No	1	GAPDH
ESRRB	SYNE4	No	1	VAPB
ESRRB	MET	No	4	GRB2, EGFR, HSP90AA1, HSP90AB1
TPRN	GRXCR1	No	1	PPP1CA
TPRN	TRIOBP	No	8	MYO1C, ACTB, ANLN, IQGAP1, MYO18A, PPP1CB, CAPZA2, MYH9
TPRN	MYO15A	No	1	EPS8
CDH23	RDX	No	1	LYN
CDH23	ATP2B2	No	1	DLG4
CDH23	PCDH15	No	1	DLG4
CDH23	MYO7A	No	1	USH1C
LRTOMT	RDX	No	1	ELAVL1
LRTOMT	MARVELD2	No	1	ELAVL1
LRTOMT	TRIOBP	No	1	ELAVL1
RDX	HGF	No	1	BRCA1
RDX	MARVELD2	No	1	ELAVL1
RDX	SERPINB6	No	1	NTRK1
RDX	TRIOBP	No	1	ELAVL1
RDX	MET	No	1	HSPA4
RDX	MYO7A	No	1	CALM1
MSRB3	MARVELD2	No	2	NXF1, MOV10
HGF	MET	Yes	1	HGF
MARVELD2	TRIOBP	No	1	ELAVL1
ATP2B2	PCDH15	No	1	DLG4
SYNE4	MYO7A	No	1	KEAP1
SERPINB6	MET	No	1	CRK
MET	MYO7A	No	2	CDH1, CTNNB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MYO3A	PTPRQ	No	-	1	MYO6
MYO3A	MYO6	Yes	binding	8	MYO1C, CALM2, CD2AP, RAC3, MYO1A, MYO9B, ESPN, DPYSL3
MYO3A	ESPN	Yes	binding	7	MYO1C, MYO6, CD2AP, RAC3, MYO1A, MYO9B, DPYSL3
MYO3A	CDH23	No	-	1	MYO1C
MYO3A	ATP2B2	No	-	1	CALM2
MYO3A	OTOF	No	-	1	MYO6
KARS	MYO6	No	-	1	UBC
KARS	RDX	No	-	1	UBC
KARS	ATP2B2	No	-	1	UBC
KARS	SERPINB6	No	-	1	UBC
KARS	MET	No	-	1	UBC
PTPRQ	MYO6	Yes	binding	0
PTPRQ	ESPN	No	-	1	MYO6
PTPRQ	HGF	No	-	1	MAPK1
PTPRQ	OTOF	No	-	1	MYO6
PTPRQ	MET	No	-	1	MAPK1
PNPT1	EPS8	No	-	1	EGFR
PNPT1	HGF	No	-	1	EGFR
PNPT1	MET	No	-	1	EGFR
KCNJ10	MYO6	No	-	1	DLG4
EPS8	MYO6	No	-	1	CDC42
EPS8	ESPN	No	-	2	BAIAP2, DFNB31
EPS8	HGF	No	-	4	SRC, CDC42, SOS1, EGFR
EPS8	MET	No	-	8	RAC1, SOS1, EGF, RAB5A, CDC42, EGFR, SRC, SHC1
EPS8	MYO15A	Yes	binding	1	DFNB31
FOXI1	SLC26A4	Yes	binding, expression	0
MYO6	ESPN	Yes	binding	7	MYO1C, CD2AP, MYO3A, RAC3, MYO1A, MYO9B, DPYSL3
MYO6	CDH23	No	-	2	MYO1C, CTNNB1
MYO6	RDX	No	-	2	UBC, CFTR
MYO6	HGF	No	-	6	CDH1, CTNND1, CDC42, TP53, CTNNB1, CTNNA1
MYO6	ATP2B2	No	-	2	UBC, CALM2
MYO6	SERPINB6	No	-	1	UBC
MYO6	OTOF	Yes	binding	0
MYO6	MET	No	-	8	MDM2, CDH1, CTNND1, CDC42, TP53, CTNNB1, UBC, CTNNA1
ESPN	CDH23	No	-	1	MYO1C
ESPN	OTOF	No	-	1	MYO6
ESPN	MYO15A	No	-	1	DFNB31
GJB2	GJB6	Yes	binding	1	CNST
GJB6	CLDN14	No	-	1	TJP1
TBC1D24	HGF	No	-	1	ARF6
TBC1D24	MET	No	-	1	ARF6
USH1C	CDH23	Yes	binding	1	PCDH15
USH1C	PCDH15	Yes	binding	1	CDH23
CLIC5	RDX	No	-	1	EZR
ESRRB	MET	No	-	1	AR
CDH23	HGF	No	-	1	CTNNB1
CDH23	MET	No	-	1	CTNNB1
CDH23	PCDH15	Yes	binding	1	USH1C
RDX	ATP2B2	No	-	1	UBC
RDX	SERPINB6	No	-	1	UBC
RDX	MET	No	-	2	UBC, RHOA
HGF	SERPINB6	No	-	1	IL6
HGF	ADCY1	No	-	1	HRAS
HGF	MET	Yes	activation, binding	47	EPS15, PLCG1, HGS, MAPK3, PTPN1, TP53, SH3KBP1, INPPL1, CDC42, SOS1, EGFR, VEGFA, CRKL, RANBP10, MAPK8, PTPN11, CRK, SDC1, PIK3CA, PTPRJ, CTNNA1, CTNNB1, WASL, KPNB1, INPP5D, RAPGEF1, NCK2, SH3GL2, HRAS, CDH1, MUC20, GAB2, PAK4, SRC, RANBP9, GRB2, NCK1, STAT3, PLAUR, ARF6, MAPK1, CTNND1, IL6, PIK3R1, GAB1, CBL, BCAR1
ATP2B2	SERPINB6	No	-	1	UBC
ATP2B2	ADCY1	No	-	3	PRKACG, PRKACA, PRKACB
ATP2B2	MET	No	-	1	UBC
SERPINB6	MET	No	-	2	UBC, IL6
ADCY1	MET	No	-	2	HRAS, S1PR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
HGF	MET	Yes	HGF-Met complex	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
KARS	USH1C	No	1	UBA1
PNPT1	RDX	No	1	NCL

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
USH1C	CDH23	Yes	2	CDH23, USH1C
HGF	MET	Yes	2	MET, HGF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
FOXI1	SLC26A4	yes, maybe indirect	FOXI1 is a transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Proteoglycans in cancer	hsa05205	5.02	3	MET, RDX, HGF
Pathways in cancer	hsa05200	3.98	3	MET, ADCY1, HGF
Rap1 signaling pathway	hsa04015	4.97	3	MET, ADCY1, HGF
Amoebiasis	hsa05146	5.82	3	ADCY1, SERPINB6, COL11A2
Focal adhesion	hsa04510	4.92	3	MET, COL11A2, HGF
PI3K-Akt signaling pathway	hsa04151	4.21	3	MET, COL11A2, HGF
Salivary secretion	hsa04970	6.23	2	ADCY1, ATP2B2
Gastric acid secretion	hsa04971	6.48	2	ADCY1, KCNJ10
Melanoma	hsa05218	6.56	2	MET, HGF
MicroRNAs in cancer	hsa05206	5.38	2	MET, RDX
Platelet activation	hsa04611	5.66	2	ADCY1, COL11A2
cGMP-PKG signaling pathway	hsa04022	5.32	2	ADCY1, ATP2B2
Calcium signaling pathway	hsa04020	5.22	2	ADCY1, ATP2B2
Renal cell carcinoma	hsa05211	6.6	2	MET, HGF
Pancreatic secretion	hsa04972	6.07	2	ADCY1, ATP2B2
cAMP signaling pathway	hsa04024	5.05	2	ADCY1, ATP2B2
Ras signaling pathway	hsa04014	4.9	2	MET, HGF
Malaria	hsa05144	7.15	2	MET, HGF
Purine metabolism	hsa00230	5.28	2	ADCY1, PNPT1
Thyroid hormone synthesis	hsa04918	6.56	2	ADCY1, SLC26A4
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	ADCY1, ATP2B2
Cytokine-cytokine receptor interaction	hsa04060	4.67	2	MET, HGF

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Infectious diseases: Parasitic	NEW	4.46	0.025	MET, ADCY1, SERPINB6, COL11A2, HGF

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Membrane Trafficking	R-HSA-199991	5.26	4	GJB6, GJB3, GJB2, MYO6
Gap junction trafficking	R-HSA-190828	7.59	4	GJB6, GJB3, GJB2, MYO6
Gap junction trafficking and regulation	R-HSA-157858	7.52	4	GJB6, GJB3, GJB2, MYO6
Vesicle-mediated transport	R-HSA-5653656	4.33	4	GJB6, GJB3, GJB2, MYO6
Gap junction assembly	R-HSA-190861	8.03	3	GJB6, GJB3, GJB2
Neuronal System	R-HSA-112316	4.82	3	ADCY1, MYO6, KCNJ10
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	R-HSA-112314	5.85	3	ADCY1, MYO6, KCNJ10
Transmission across Chemical Synapses	R-HSA-112315	5.28	3	ADCY1, MYO6, KCNJ10
Hemostasis	R-HSA-109582	3.98	3	SERPINB6, ATP2B2, HGF
Signal Transduction	R-HSA-162582	1.78	3	S1PR2, ADCY1, MYO7A
Signaling by GPCR	R-HSA-372790	2.68	2	S1PR2, ADCY1
Gene Expression	R-HSA-74160	2.72	2	ESRRB, KARS
GABA B receptor activation	R-HSA-977444	7.7	2	ADCY1, KCNJ10
Immune System	R-HSA-168256	2.37	2	ADCY1, HGF
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	ADCY1, ATP2B2
GABA receptor activation	R-HSA-977443	7.2	2	ADCY1, KCNJ10
GPCR downstream signaling	R-HSA-388396	3.07	2	S1PR2, ADCY1
Activation of GABAB receptors	R-HSA-991365	7.7	2	ADCY1, KCNJ10
G alpha (i) signalling events	R-HSA-418594	5.1	2	S1PR2, ADCY1
Axon guidance	R-HSA-422475	3.93	2	MET, RDX
Developmental Biology	R-HSA-1266738	3.48	2	MET, RDX

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Membrane Trafficking (R-HSA-199991)	-	5.26	0.01	MYO6, MET, GJB6, MYO3A, EPS8, GJB3, GJB2
Gap junction trafficking (R-HSA-190828)	-	7.59	0.003	GJB6, GJB3, GJB2, MYO6
Gap junction trafficking and regulation (R-HSA-157858)	-	7.52	0.0	GJB6, GJB3, GJB2, MYO6
Gap junction assembly (R-HSA-190861)	-	8.03	0.028	GJB6, GJB3, GJB2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	39	CABP2, LHFPL5, MSRB3, COL11A2, MET, CDH23, GRXCR2, DCDC2, MARVELD2, S1PR2, MYO6, RDX, USH1C, SERPINB6, TRIOBP, EPS8, SLC26A5, ELMOD3, CLIC5, SYNE4, TBC1D24, TPRN, MYO15A, HGF, ESPN, MYO3A, CLDN14, CIB2, ATP2B2, ESRRB, OTOF, ADCY1, FAM65B, KARS, KCNJ10, PCDH15, PNPT1, MYO7A, FOXI1
protein binding (GO:0005515)	0.46	37	LHFPL5, MARVELD2, COL11A2, MET, CDH23, GRXCR2, CIB2, DCDC2, MSRB3, S1PR2, MYO6, RDX, USH1C, TRIOBP, EPS8, SLC26A5, ELMOD3, CLIC5, SYNE4, TBC1D24, TPRN, MYO15A, HGF, ESPN, SERPINB6, CLDN14, MYO3A, ATP2B2, ESRRB, OTOF, ADCY1, FAM65B, KARS, KCNJ10, PCDH15, PNPT1, MYO7A
catalytic activity (GO:0003824)	1.05	18	ADCY1, MYO15A, ATP2B2, MYO6, KARS, MET, OTOGL, PNPT1, MYO3A, HGF, PTPRQ, CLIC5, LRTOMT, MSRB3, MYO7A, TMPRSS3, OTOG, GRXCR1
organic cyclic compound binding (GO:0097159)	1.05	13	ADCY1, MYO15A, KCNJ10, KARS, RDX, MYO6, MYO3A, MET, PNPT1, ATP2B2, MYO7A, ESRRB, FOXI1
heterocyclic compound binding (GO:1901363)	1.06	13	ADCY1, MYO15A, KCNJ10, KARS, RDX, MYO6, MYO3A, MET, PNPT1, ATP2B2, MYO7A, ESRRB, FOXI1
hydrolase activity (GO:0016787)	1.9	11	MYO15A, HGF, MYO6, OTOGL, PTPRQ, MYO3A, PNPT1, ATP2B2, MYO7A, TMPRSS3, OTOG
ion binding (GO:0043167)	1.36	11	ADCY1, CABP2, KARS, COL11A2, CDH23, CIB2, PCDH15, MSRB3, ATP2B2, ESRRB, OTOF
metal ion binding (GO:0046872)	1.41	11	ADCY1, CABP2, KARS, COL11A2, CDH23, CIB2, PCDH15, MSRB3, ATP2B2, ESRRB, OTOF
cation binding (GO:0043169)	1.4	11	ADCY1, CABP2, KARS, COL11A2, CDH23, CIB2, PCDH15, MSRB3, ATP2B2, ESRRB, OTOF
cytoskeletal protein binding (GO:0008092)	3.02	10	MYO15A, MYO6, RDX, ESPN, MYO3A, SLC26A5, TRIOBP, EPS8, MYO7A, USH1C
small molecule binding (GO:0036094)	1.89	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
protein complex binding (GO:0032403)	3.09	9	S1PR2, OTOF, MYO6, ESPN, PCDH15, CIB2, TRIOBP, MYO7A, USH1C
adenyl ribonucleotide binding (GO:0032559)	2.41	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
adenyl nucleotide binding (GO:0030554)	2.4	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
carbohydrate derivative binding (GO:0097367)	2.03	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
transporter activity (GO:0005215)	2.57	9	SLC26A4, KCNJ10, LOXHD1, TMC1, SLC26A5, CLIC5, ATP2B2, GJB2, GJB3
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
nucleotide binding (GO:0000166)	1.96	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
actin binding (GO:0003779)	3.74	9	MYO15A, MYO6, RDX, ESPN, EPS8, TRIOBP, MYO3A, MYO7A, USH1C
ribonucleotide binding (GO:0032553)	2.19	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
transmembrane transporter activity (GO:0022857)	2.82	9	SLC26A4, KCNJ10, LOXHD1, TMC1, SLC26A5, CLIC5, ATP2B2, GJB2, GJB3
macromolecular complex binding (GO:0044877)	2.61	9	S1PR2, OTOF, MYO6, ESPN, PCDH15, CIB2, TRIOBP, MYO7A, USH1C
ATP binding (GO:0005524)	2.43	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
purine nucleoside binding (GO:0001883)	2.22	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
ribonucleoside binding (GO:0032549)	2.22	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
purine ribonucleotide binding (GO:0032555)	2.2	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
purine nucleotide binding (GO:0017076)	2.19	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
purine ribonucleoside binding (GO:0032550)	2.22	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
nucleoside phosphate binding (GO:1901265)	1.96	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
nucleoside binding (GO:0001882)	2.21	9	ADCY1, MYO15A, KARS, MYO6, MET, MYO3A, KCNJ10, ATP2B2, MYO7A
passive transmembrane transporter activity (GO:0022803)	3.6	8	SLC26A4, KCNJ10, LOXHD1, TMC1, SLC26A5, CLIC5, GJB2, GJB3
channel activity (GO:0015267)	3.6	8	SLC26A4, KCNJ10, LOXHD1, TMC1, SLC26A5, CLIC5, GJB2, GJB3
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	7	SLC26A4, KCNJ10, TMC1, SLC26A5, CLIC5, ATP2B2, LOXHD1
ion transmembrane transporter activity (GO:0015075)	3.04	7	SLC26A4, KCNJ10, TMC1, SLC26A5, CLIC5, ATP2B2, LOXHD1
substrate-specific transporter activity (GO:0022892)	2.72	7	SLC26A4, KCNJ10, TMC1, SLC26A5, CLIC5, ATP2B2, LOXHD1
ion channel activity (GO:0005216)	3.71	6	SLC26A4, KCNJ10, TMC1, SLC26A5, CLIC5, LOXHD1
enzyme binding (GO:0019899)	2.27	6	RDX, SERPINB6, MET, TRIOBP, EPS8, TPRN
molecular transducer activity (GO:0060089)	2.32	6	S1PR2, KCNJ10, MET, ILDR1, TMPRSS3, ESRRB
calmodulin binding (GO:0005516)	4.55	6	ADCY1, MYO15A, MYO7A, MYO6, MYO3A, ATP2B2
receptor activity (GO:0004872)	2.32	6	S1PR2, KCNJ10, MET, ILDR1, TMPRSS3, ESRRB
substrate-specific channel activity (GO:0022838)	3.67	6	SLC26A4, KCNJ10, TMC1, SLC26A5, CLIC5, LOXHD1
identical protein binding (GO:0042802)	2.63	6	HGF, RDX, CIB2, SLC26A5, CLDN14, MYO7A
calcium ion binding (GO:0005509)	3.17	6	CABP2, OTOF, CDH23, CIB2, PCDH15, ATP2B2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	5	MYO15A, MYO6, ATP2B2, MYO3A, MYO7A
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	5	MYO15A, MYO6, ATP2B2, MYO3A, MYO7A
actin filament binding (GO:0051015)	4.93	5	ESPN, TRIOBP, USH1C, MYO6, MYO7A
nucleoside-triphosphatase activity (GO:0017111)	3.09	5	MYO15A, MYO6, ATP2B2, MYO3A, MYO7A
pyrophosphatase activity (GO:0016462)	3.04	5	MYO15A, MYO6, ATP2B2, MYO3A, MYO7A
transferase activity (GO:0016740)	1.95	5	MET, PNPT1, CLIC5, LRTOMT, MYO3A
nucleic acid binding (GO:0003676)	1.44	5	RDX, PNPT1, ESRRB, KARS, FOXI1
protein dimerization activity (GO:0046983)	2.72	5	SLC26A5, RDX, MYO7A, CIB2, HGF
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	4	LOXHD1, TMC1, KCNJ10, ATP2B2
cation transmembrane transporter activity (GO:0008324)	3.32	4	LOXHD1, TMC1, KCNJ10, ATP2B2
structural molecule activity (GO:0005198)	3.1	4	OTOG, CLDN14, COL11A2, TECTA
protein domain specific binding (GO:0019904)	3.32	4	RDX, ESPN, MYO7A, ATP2B2
metal ion transmembrane transporter activity (GO:0046873)	3.71	4	LOXHD1, TMC1, KCNJ10, ATP2B2
molecular function regulator (GO:0098772)	2.51	4	TMPRSS3, ELMOD3, TBC1D24, SERPINB6
motor activity (GO:0003774)	4.81	4	MYO15A, MYO6, MYO7A, MYO3A
protein homodimerization activity (GO:0042803)	3.16	4	SLC26A5, RDX, MYO7A, CIB2
cation channel activity (GO:0005261)	4.04	3	LOXHD1, TMC1, KCNJ10
ATPase activity (GO:0016887)	3.65	3	MYO7A, ATP2B2, MYO3A
signal transducer activity (GO:0004871)	2.28	3	MET, S1PR2, ESRRB
signaling receptor activity (GO:0038023)	2.49	3	MET, S1PR2, ESRRB
spectrin binding (GO:0030507)	6.48	3	SLC26A5, USH1C, MYO7A
calcium ion transmembrane transporter activity (GO:0015085)	4.89	3	LOXHD1, TMC1, ATP2B2
microfilament motor activity (GO:0000146)	6.65	3	MYO6, MYO7A, MYO3A
ATPase activity, coupled (GO:0042623)	3.97	3	MYO7A, ATP2B2, MYO3A
anion transmembrane transporter activity (GO:0008509)	4.43	3	SLC26A5, CLIC5, SLC26A4
divalent inorganic cation transmembrane transporter activity (GO:0072509)	4.62	3	LOXHD1, TMC1, ATP2B2
inorganic anion transmembrane transporter activity (GO:0015103)	4.87	3	SLC26A5, CLIC5, SLC26A4
anion channel activity (GO:0005253)	5.23	3	SLC26A5, CLIC5, SLC26A4
chloride channel activity (GO:0005254)	5.36	3	SLC26A5, CLIC5, SLC26A4
chloride transmembrane transporter activity (GO:0015108)	5.24	3	SLC26A5, CLIC5, SLC26A4
active transmembrane transporter activity (GO:0022804)	3.85	3	SLC26A5, SLC26A4, ATP2B2
RNA binding (GO:0003723)	2.36	3	RDX, PNPT1, KARS
enzyme regulator activity (GO:0030234)	2.85	3	ELMOD3, TBC1D24, SERPINB6
ADP binding (GO:0043531)	6.24	3	MYO6, MYO7A, MYO3A
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	MET, PNPT1, MYO3A
voltage-gated channel activity (GO:0022832)	4.49	3	TMC1, CLIC5, KCNJ10
gated channel activity (GO:0022836)	3.96	3	TMC1, CLIC5, KCNJ10
receptor binding (GO:0005102)	2.43	3	S1PR2, CIB2, HGF
voltage-gated ion channel activity (GO:0005244)	4.49	3	TMC1, CLIC5, KCNJ10
transmembrane receptor activity (GO:0099600)	2.53	3	S1PR2, MET, KCNJ10
ion antiporter activity (GO:0099516)	5.75	2	SLC26A5, SLC26A4
serine-type endopeptidase activity (GO:0004252)	4.4	2	TMPRSS3, HGF
extracellular matrix structural constituent (GO:0005201)	5.37	2	COL11A2, TECTA
cargo receptor activity (GO:0038024)	5.53	2	TMPRSS3, ILDR1
alpha-L-arabinofuranosidase activity (GO:0046556)	9.05	2	OTOGL, OTOG
wide pore channel activity (GO:0022829)	6.6	2	GJB3, GJB2
calcium channel activity (GO:0005262)	5.03	2	LOXHD1, TMC1
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	ESRRB, FOXI1
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	2	ESRRB, FOXI1
hydrolase activity, acting on glycosyl bonds (GO:0016798)	4.91	2	OTOGL, OTOG
Rho GTPase binding (GO:0017048)	5.36	2	TRIOBP, EPS8
small GTPase binding (GO:0031267)	4.13	2	TRIOBP, EPS8
GTPase binding (GO:0051020)	4.05	2	TRIOBP, EPS8
endopeptidase activity (GO:0004175)	3.63	2	TMPRSS3, HGF
secondary active sulfate transmembrane transporter activity (GO:0008271)	7.17	2	SLC26A5, SLC26A4
zinc ion binding (GO:0008270)	2.66	2	ESRRB, MSRB3
DNA binding (GO:0003677)	1.92	2	ESRRB, FOXI1
enzyme activator activity (GO:0008047)	3.56	2	ELMOD3, TBC1D24
peptidase activity (GO:0008233)	3.23	2	TMPRSS3, HGF
serine-type peptidase activity (GO:0008236)	4.27	2	TMPRSS3, HGF
sequence-specific DNA binding (GO:0043565)	2.79	2	ESRRB, FOXI1
sulfur compound transmembrane transporter activity (GO:1901682)	6.44	2	SLC26A5, SLC26A4
transition metal ion binding (GO:0046914)	2.48	2	ESRRB, MSRB3
oxalate transmembrane transporter activity (GO:0019531)	7.34	2	SLC26A5, SLC26A4
bicarbonate transmembrane transporter activity (GO:0015106)	6.79	2	SLC26A5, SLC26A4
voltage-gated cation channel activity (GO:0022843)	4.83	2	TMC1, KCNJ10
oxidoreductase activity, acting on a sulfur group of donors (GO:0016667)	5.83	2	MSRB3, GRXCR1
protein kinase activity (GO:0004672)	3.27	2	MET, MYO3A
double-stranded DNA binding (GO:0003690)	3.09	2	ESRRB, FOXI1
oxidoreductase activity (GO:0016491)	3.12	2	MSRB3, GRXCR1
poly(A) RNA binding (GO:0044822)	2.69	2	RDX, PNPT1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	2	ESRRB, FOXI1
regulatory region DNA binding (GO:0000975)	3.03	2	ESRRB, FOXI1
integrin binding (GO:0005178)	5.07	2	S1PR2, CIB2
antiporter activity (GO:0015297)	5.33	2	SLC26A5, SLC26A4
secondary active transmembrane transporter activity (GO:0015291)	4.29	2	SLC26A5, SLC26A4
organic anion transmembrane transporter activity (GO:0008514)	5.31	2	SLC26A5, SLC26A4
serine hydrolase activity (GO:0017171)	4.26	2	TMPRSS3, HGF
GTPase activator activity (GO:0005096)	4.11	2	ELMOD3, TBC1D24
transcription factor binding (GO:0008134)	3.46	2	SLC26A5, ESRRB
kinase activity (GO:0016301)	2.93	2	MET, MYO3A
regulatory region nucleic acid binding (GO:0001067)	3.03	2	ESRRB, FOXI1
lipid binding (GO:0008289)	3.26	2	S1PR2, ESRRB
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	2	PNPT1, PTPRQ
Ras GTPase binding (GO:0017016)	4.2	2	TRIOBP, EPS8
GTPase regulator activity (GO:0030695)	4.01	2	ELMOD3, TBC1D24
myosin binding (GO:0017022)	5.66	2	TRIOBP, USH1C
phosphatase binding (GO:0019902)	4.63	2	MET, TPRN
actin-dependent ATPase activity (GO:0030898)	7.17	2	MYO7A, MYO3A
cell adhesion molecule binding (GO:0050839)	4.5	2	S1PR2, CIB2
nucleoside-triphosphatase regulator activity (GO:0060589)	3.92	2	ELMOD3, TBC1D24
binding, bridging (GO:0060090)	4.57	2	EPS8, COL11A2
transcription regulatory region DNA binding (GO:0044212)	3.03	2	ESRRB, FOXI1
protein binding, bridging (GO:0030674)	4.68	2	EPS8, COL11A2
protein N-terminus binding (GO:0047485)	5.11	2	PCDH15, MYO7A
anion:anion antiporter activity (GO:0015301)	6.41	2	SLC26A5, SLC26A4
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	MET, MYO3A
sulfate transmembrane transporter activity (GO:0015116)	7.17	2	SLC26A5, SLC26A4
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	2	ESRRB, FOXI1
transmembrane signaling receptor activity (GO:0004888)	2.57	2	MET, S1PR2
peptidase activity, acting on L-amino acid peptides (GO:0070011)	3.26	2	TMPRSS3, HGF
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	ESRRB, FOXI1
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	2	ESRRB, FOXI1
hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)	5.14	2	OTOGL, OTOG
gap junction channel activity (GO:0005243)	7.1	2	GJB3, GJB2
nucleic acid binding transcription factor activity (GO:0001071)	2.65	2	ESRRB, FOXI1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
alpha-L-arabinofuranosidase activity (GO:0046556)	-	9.05	0.002	OTOGL, OTOG
microfilament motor activity (GO:0000146)	-	6.65	0.02	MYO6, MYO7A, MYO3A
cytoskeletal protein binding (GO:0008092)	-	3.02	0.002	S1PR2, MYO15A, KCNJ10, KARS, HGF, RDX, ESPN, MYO6, CDH23, PCDH15, MYO3A, SLC26A5, TRIOBP, EPS8, DFNB31, MYO7A, SYNE4, USH1C
actin filament binding (GO:0051015)	-	4.93	0.001	ESPN, TRIOBP, MYO6, MYO7A, MYO3A
actin binding (GO:0003779)	-	3.74	0.002	MYO15A, DFNB31, MYO6, RDX, ESPN, PCDH15, MYO3A, TRIOBP, EPS8, MYO7A, SYNE4, USH1C
transmembrane transporter activity (GO:0022857)	-	2.82	0.031	MET, KCNJ10, MYO6, LOXHD1, RDX, TMC1, SLC26A4, MYO3A, SLC26A5, GJB6, CLIC5, EPS8, HGF, ATP2B2, GJB3, GJB2
calmodulin binding (GO:0005516)	-	4.55	0.002	ADCY1, MYO15A, ATP2B2, MYO6, EPS8, MYO3A, DFNB31, MYO7A
ADP binding (GO:0043531)	-	6.24	0.012	MYO6, MYO7A, MYO3A
motor activity (GO:0003774)	-	4.81	0.022	MYO15A, MYO7A, MYO6, EPS8, MYO3A, DFNB31
spectrin binding (GO:0030507)	-	6.48	0.006	SLC26A5, USH1C, MYO7A

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism process (GO:0044699)	0.48	45	LHFPL5, STRC, MSRB3, COL11A2, MET, CDH23, OTOA, LRTOMT, PTPRQ, DCDC2, MARVELD2, GJB3, S1PR2, TMIE, MYO6, RDX, USH1C, TMC1, EPS8, SLC26A5, TRIOBP, CLIC5, MYO7A, TMPRSS3, SYNE4, TBC1D24, GRXCR1, MYO15A, HGF, OTOGL, SLC26A4, CIB2, PCDH15, ATP2B2, GJB2, ESRRB, OTOF, ADCY1, FAM65B, KCNJ10, KARS, GJB6, PNPT1, OTOG, FOXI1
cellular process (GO:0009987)	0.26	44	LHFPL5, STRC, MARVELD2, COL11A2, MET, CDH23, LRTOMT, PTPRQ, DCDC2, MSRB3, GJB3, S1PR2, MYO6, RDX, ESRRB, TMC1, SERPINB6, EPS8, SLC26A5, TRIOBP, CLIC5, TMPRSS3, SYNE4, TBC1D24, GRXCR1, HGF, ESPN, SLC26A4, MYO3A, CLDN14, CIB2, ATP2B2, GJB2, USH1C, OTOF, ADCY1, FAM65B, KARS, KCNJ10, GJB6, PCDH15, PNPT1, MYO7A, FOXI1
multicellular organismal process (GO:0032501)	1.45	44	LHFPL5, STRC, COL11A2, MET, CDH23, GRXCR2, LRTOMT, CIB2, PTPRQ, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, OTOF, TMC1, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, ESPN, TPRN, MYO15A, OTOGL, OTOA, SERPINB6, PCDH15, MYO3A, ATP2B2, GJB2, USH1C, ADCY1, FAM65B, SLC26A4, KCNJ10, GRXCR1, GJB6, MYO6, FOXI1, OTOG, TSPEAR
neurological system process (GO:0050877)	2.64	40	LHFPL5, STRC, COL11A2, CDH23, GRXCR2, LRTOMT, PTPRQ, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, TMC1, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, ESPN, TPRN, MYO15A, OTOGL, OTOA, SERPINB6, PCDH15, MYO3A, ATP2B2, GJB2, USH1C, OTOF, ADCY1, FAM65B, SLC26A4, KCNJ10, GJB6, GRXCR1, OTOG, TSPEAR
system process (GO:0003008)	2.3	40	LHFPL5, STRC, COL11A2, CDH23, GRXCR2, LRTOMT, PTPRQ, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, OTOF, TMC1, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, ESPN, TPRN, MYO15A, OTOGL, OTOA, MYO3A, PCDH15, SERPINB6, ATP2B2, GJB2, USH1C, ADCY1, FAM65B, SLC26A4, KCNJ10, GJB6, MYO6, GRXCR1, OTOG, TSPEAR
sensory perception (GO:0007600)	2.93	38	LHFPL5, STRC, COL11A2, CDH23, GRXCR2, LRTOMT, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, TMC1, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, ESPN, TPRN, MYO15A, OTOGL, OTOA, MYO3A, PCDH15, SERPINB6, ATP2B2, GJB2, USH1C, OTOF, FAM65B, SLC26A4, KCNJ10, GJB6, GRXCR1, OTOG, TSPEAR
sensory perception of sound (GO:0007605)	4.82	37	LHFPL5, STRC, COL11A2, CDH23, GRXCR2, LRTOMT, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, TMC1, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, ESPN, GRXCR1, MYO15A, OTOGL, OTOA, MYO3A, PCDH15, SERPINB6, ATP2B2, GJB2, USH1C, FAM65B, OTOF, SLC26A4, GJB6, TPRN, OTOG, TSPEAR
sensory perception of mechanical stimulus (GO:0050954)	4.79	37	LHFPL5, STRC, COL11A2, CDH23, GRXCR2, LRTOMT, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, TMC1, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, ESPN, TPRN, MYO15A, OTOGL, OTOA, SERPINB6, PCDH15, MYO3A, ATP2B2, GJB2, USH1C, FAM65B, OTOF, SLC26A4, GJB6, GRXCR1, OTOG, TSPEAR
single-organism cellular process (GO:0044763)	0.65	37	LHFPL5, STRC, COL11A2, MET, CDH23, LRTOMT, PTPRQ, DCDC2, MARVELD2, GJB3, S1PR2, MYO6, RDX, TMC1, EPS8, SLC26A5, TRIOBP, CLIC5, KCNJ10, TMPRSS3, SYNE4, TBC1D24, GRXCR1, HGF, CIB2, PCDH15, ATP2B2, GJB2, USH1C, OTOF, ADCY1, FAM65B, KARS, SLC26A4, GJB6, PNPT1, MYO7A
biological regulation (GO:0065007)	0.39	32	CABP2, COL11A2, MET, CDH23, LRTOMT, PTPRQ, DCDC2, S1PR2, MYO6, RDX, USH1C, TRIOBP, EPS8, SLC26A5, ELMOD3, CLIC5, TMPRSS3, TBC1D24, GRXCR1, HGF, ESPN, ILDR1, CIB2, SERPINB6, ATP2B2, ESRRB, ADCY1, SLC26A4, KCNJ10, GJB6, PNPT1, FOXI1
cellular component organization (GO:0016043)	1.24	28	LHFPL5, STRC, COL11A2, MET, CDH23, PTPRQ, DCDC2, MARVELD2, S1PR2, OTOF, RDX, EPS8, SLC26A5, TRIOBP, CLIC5, SYNE4, TBC1D24, GRXCR1, HGF, ESPN, CLDN14, ATP2B2, GJB2, USH1C, ADCY1, PCDH15, PNPT1, MYO7A
cellular component organization or biogenesis (GO:0071840)	1.22	28	LHFPL5, STRC, COL11A2, MET, CDH23, PTPRQ, DCDC2, MARVELD2, S1PR2, OTOF, RDX, EPS8, SLC26A5, TRIOBP, CLIC5, SYNE4, TBC1D24, GRXCR1, HGF, ESPN, CLDN14, ATP2B2, GJB2, USH1C, ADCY1, PCDH15, PNPT1, MYO7A
developmental process (GO:0032502)	1.36	26	MYO7A, COL11A2, MET, LRTOMT, PTPRQ, DCDC2, MARVELD2, GJB3, TMIE, OTOF, RDX, TMC1, SLC26A5, GRXCR1, MYO15A, HGF, PCDH15, ATP2B2, GJB2, ESRRB, ADCY1, FAM65B, KCNJ10, GJB6, PNPT1, FOXI1
regulation of biological process (GO:0050789)	0.45	26	CABP2, MET, PTPRQ, DCDC2, S1PR2, MYO6, RDX, ESRRB, EPS8, SLC26A5, TRIOBP, CLIC5, TBC1D24, GRXCR1, HGF, ESPN, ILDR1, SERPINB6, ATP2B2, USH1C, ADCY1, SLC26A4, KCNJ10, GJB6, PNPT1, FOXI1
single-organism developmental process (GO:0044767)	1.49	25	MYO7A, COL11A2, MET, LRTOMT, PTPRQ, MARVELD2, GJB3, TMIE, OTOF, RDX, TMC1, SLC26A5, GRXCR1, MYO15A, HGF, PCDH15, ATP2B2, GJB2, ESRRB, ADCY1, FAM65B, KCNJ10, GJB6, PNPT1, FOXI1
regulation of cellular process (GO:0050794)	0.5	24	CABP2, MET, PTPRQ, DCDC2, S1PR2, MYO6, RDX, ESRRB, EPS8, SLC26A5, TRIOBP, TBC1D24, GRXCR1, HGF, ESPN, ILDR1, SERPINB6, ATP2B2, USH1C, ADCY1, KCNJ10, GJB6, PNPT1, FOXI1
response to stimulus (GO:0050896)	1.22	22	LHFPL5, MSRB3, CDH23, CIB2, PTPRQ, DCDC2, STRC, GJB2, MYO6, RDX, TMC1, SLC26A5, CLIC5, HGF, SERPINB6, PCDH15, MYO3A, ATP2B2, LOXHD1, ADCY1, GJB6, PNPT1
localization (GO:0051179)	1.4	21	SLC26A5, LHFPL5, ATP2B2, KCNJ10, MYO6, RDX, CDH23, TMC1, ILDR1, SLC26A4, GJB2, HGF, PNPT1, CLIC5, GJB3, MYO7A, TMPRSS3, SYNE4, USH1C, LOXHD1, OTOF
anatomical structure development (GO:0048856)	1.58	20	MARVELD2, FAM65B, TMC1, KCNJ10, COL11A2, HGF, RDX, GJB6, LRTOMT, SLC26A5, PCDH15, DCDC2, GRXCR1, ATP2B2, MYO7A, GJB3, ESRRB, GJB2, FOXI1, OTOF
establishment of localization (GO:0051234)	1.48	20	LHFPL5, ATP2B2, OTOF, KCNJ10, HGF, RDX, CDH23, TMC1, MYO6, ILDR1, SLC26A4, SYNE4, SLC26A5, PNPT1, LOXHD1, MYO7A, TMPRSS3, CLIC5, GJB2, GJB3
metabolic process (GO:0008152)	0.58	19	ADCY1, ATP2B2, KARS, COL11A2, MET, OTOGL, PTPRQ, PNPT1, MYO3A, HGF, TRIOBP, CLIC5, LRTOMT, MSRB3, TMPRSS3, FOXI1, OTOG, ESRRB, GRXCR1
cellular developmental process (GO:0048869)	1.82	18	ADCY1, FAM65B, KCNJ10, COL11A2, HGF, RDX, TMC1, PTPRQ, MARVELD2, PCDH15, MET, PNPT1, LRTOMT, MYO7A, ATP2B2, SYNE4, USH1C, GRXCR1
transport (GO:0006810)	1.51	18	LHFPL5, ATP2B2, GJB3, MYO6, KCNJ10, CDH23, TMC1, ILDR1, SLC26A4, SLC26A5, PNPT1, CLIC5, HGF, MYO7A, TMPRSS3, GJB2, LOXHD1, OTOF
regulation of biological quality (GO:0065008)	1.68	18	ADCY1, S1PR2, KCNJ10, COL11A2, RDX, CDH23, GJB6, EPS8, ILDR1, SLC26A4, LRTOMT, SLC26A5, TRIOBP, CIB2, ATP2B2, TMPRSS3, USH1C, GRXCR1
organic substance metabolic process (GO:0071704)	0.63	18	ADCY1, ATP2B2, KARS, COL11A2, MET, OTOGL, PTPRQ, TRIOBP, MYO3A, HGF, PNPT1, CLIC5, LRTOMT, MSRB3, TMPRSS3, OTOG, ESRRB, FOXI1
positive regulation of biological process (GO:0048518)	1.2	16	ADCY1, S1PR2, HGF, MYO6, MET, ESPN, ILDR1, TRIOBP, EPS8, SLC26A5, RDX, PNPT1, DCDC2, ATP2B2, ESRRB, FOXI1
single-multicellular organism process (GO:0044707)	1.78	16	ADCY1, FAM65B, KCNJ10, COL11A2, MET, CDH23, OTOA, CIB2, PCDH15, CLIC5, EPS8, ATP2B2, GJB3, USH1C, OTOG, FOXI1
primary metabolic process (GO:0044238)	0.69	15	ADCY1, ATP2B2, KARS, HGF, MET, OTOGL, PTPRQ, PNPT1, MYO3A, TRIOBP, MSRB3, TMPRSS3, OTOG, ESRRB, FOXI1
positive regulation of cellular process (GO:0048522)	1.3	15	ADCY1, S1PR2, HGF, MYO6, MET, ESPN, ILDR1, TRIOBP, EPS8, SLC26A5, RDX, PNPT1, DCDC2, ESRRB, FOXI1
cell projection organization (GO:0030030)	3.14	13	ADCY1, S1PR2, LHFPL5, ATP2B2, RDX, CDH23, PCDH15, CLIC5, STRC, DCDC2, MYO7A, TBC1D24, GRXCR1
anatomical structure morphogenesis (GO:0009653)	2.53	13	ADCY1, TMIE, MYO15A, HGF, COL11A2, MET, GJB6, PCDH15, PTPRQ, PNPT1, ATP2B2, MYO7A, FOXI1
cellular component assembly (GO:0022607)	2.14	13	S1PR2, MARVELD2, PCDH15, RDX, ESPN, CLDN14, EPS8, SLC26A5, PNPT1, MYO7A, GJB2, USH1C, SYNE4
cellular metabolic process (GO:0044237)	0.69	13	ADCY1, ATP2B2, KARS, MET, PNPT1, MYO3A, PTPRQ, CLIC5, LRTOMT, MSRB3, TRIOBP, ESRRB, FOXI1
negative regulation of biological process (GO:0048519)	1.33	12	S1PR2, HGF, RDX, ESPN, TRIOBP, EPS8, SLC26A5, MET, PNPT1, SERPINB6, GJB6, GRXCR1
macromolecule metabolic process (GO:0043170)	0.83	12	KARS, COL11A2, MET, PTPRQ, TRIOBP, MYO3A, HGF, PNPT1, MSRB3, TMPRSS3, ESRRB, FOXI1
homeostatic process (GO:0042592)	2.61	11	ADCY1, KCNJ10, COL11A2, GJB6, CDH23, SLC26A4, CIB2, SLC26A5, ATP2B2, TMPRSS3, GRXCR1
single-organism metabolic process (GO:0044710)	1.63	11	ADCY1, KARS, COL11A2, OTOGL, TRIOBP, PTPRQ, CLIC5, MSRB3, ATP2B2, OTOG, GRXCR1
regulation of cellular metabolic process (GO:0031323)	1.07	11	ADCY1, S1PR2, HGF, MYO6, RDX, SERPINB6, MET, PNPT1, GRXCR1, ESRRB, FOXI1
regulation of metabolic process (GO:0019222)	1.02	11	ADCY1, S1PR2, MYO6, HGF, RDX, SERPINB6, MET, PNPT1, FOXI1, ESRRB, GRXCR1
negative regulation of cellular process (GO:0048523)	1.41	11	S1PR2, HGF, RDX, ESPN, TRIOBP, EPS8, MET, PNPT1, SERPINB6, GJB6, GRXCR1
response to abiotic stimulus (GO:0009628)	2.8	10	LHFPL5, ATP2B2, GJB6, PCDH15, SERPINB6, SLC26A5, PTPRQ, STRC, LOXHD1, TMC1
regulation of primary metabolic process (GO:0080090)	1.08	10	ADCY1, S1PR2, HGF, MYO6, RDX, SERPINB6, MET, PNPT1, ESRRB, FOXI1
response to external stimulus (GO:0009605)	2.55	10	LHFPL5, ATP2B2, GJB6, PCDH15, SLC26A5, PTPRQ, CLIC5, STRC, LOXHD1, TMC1
regulation of macromolecule metabolic process (GO:0060255)	1.08	10	ADCY1, S1PR2, HGF, MYO6, MET, SERPINB6, RDX, PNPT1, ESRRB, FOXI1
signal transduction (GO:0007165)	1.28	10	ADCY1, CABP2, HGF, MYO6, RDX, EPS8, MET, DCDC2, S1PR2, ESRRB
response to chemical (GO:0042221)	1.98	10	ADCY1, MYO6, HGF, RDX, GJB6, PCDH15, CIB2, SLC26A5, PNPT1, GJB2
regulation of localization (GO:0032879)	1.94	10	KCNJ10, MYO6, RDX, ILDR1, SLC26A4, SLC26A5, MET, CLIC5, HGF, ATP2B2
organelle organization (GO:0006996)	2.02	9	S1PR2, MYO7A, HGF, TRIOBP, EPS8, PCDH15, PNPT1, ATP2B2, SYNE4
cellular response to stimulus (GO:0051716)	1.97	9	ADCY1, HGF, MYO6, RDX, GJB6, CIB2, PNPT1, SERPINB6, GJB2
positive regulation of cellular metabolic process (GO:0031325)	1.81	9	ADCY1, S1PR2, HGF, MYO6, RDX, MET, PNPT1, ESRRB, FOXI1
positive regulation of metabolic process (GO:0009893)	1.74	9	ADCY1, S1PR2, HGF, MYO6, RDX, MET, PNPT1, ESRRB, FOXI1
cellular macromolecule metabolic process (GO:0044260)	0.93	9	KARS, MET, TRIOBP, PTPRQ, PNPT1, MYO3A, MSRB3, ESRRB, FOXI1
regulation of developmental process (GO:0050793)	2.1	9	S1PR2, HGF, RDX, PNPT1, EPS8, SLC26A5, TRIOBP, DCDC2, TBC1D24
ion transport (GO:0006811)	2.66	9	LHFPL5, SLC26A4, KCNJ10, TMC1, CDH23, SLC26A5, CLIC5, ATP2B2, LOXHD1
behavior (GO:0007610)	3.47	9	ADCY1, MYO15A, KCNJ10, ESPN, CDH23, EPS8, PCDH15, ATP2B2, OTOG
regulation of cellular component organization (GO:0051128)	2.01	9	HGF, RDX, USH1C, ESPN, EPS8, SLC26A5, TRIOBP, DCDC2, TBC1D24
nitrogen compound metabolic process (GO:0006807)	1.13	9	ADCY1, HGF, KARS, LRTOMT, PNPT1, CLIC5, ATP2B2, ESRRB, FOXI1
chemical homeostasis (GO:0048878)	2.97	9	ADCY1, SLC26A4, KCNJ10, GJB6, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3
transmembrane transport (GO:0055085)	2.72	9	SLC26A4, KCNJ10, LOXHD1, TMC1, SLC26A5, CLIC5, ATP2B2, GJB2, GJB3
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	9	ADCY1, S1PR2, HGF, MYO6, RDX, MET, PNPT1, ESRRB, FOXI1
cellular homeostasis (GO:0019725)	3.23	8	SLC26A4, GJB6, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3, GRXCR1
locomotory behavior (GO:0007626)	4.53	8	MYO15A, KCNJ10, ESPN, CDH23, EPS8, PCDH15, ATP2B2, OTOG
cell differentiation (GO:0030154)	2.14	8	FAM65B, ATP2B2, COL11A2, PTPRQ, PCDH15, MYO7A, SYNE4, USH1C
protein metabolic process (GO:0019538)	1.45	8	HGF, KARS, MET, PTPRQ, MYO3A, TRIOBP, MSRB3, TMPRSS3
regulation of catalytic activity (GO:0050790)	1.97	8	ADCY1, S1PR2, HGF, RDX, SERPINB6, ELMOD3, TBC1D24, GRXCR1
cell development (GO:0048468)	3.28	8	FAM65B, MYO7A, KCNJ10, RDX, TMC1, LRTOMT, MARVELD2, GRXCR1
response to mechanical stimulus (GO:0009612)	4.41	8	LHFPL5, ATP2B2, TMC1, PCDH15, SLC26A5, PTPRQ, STRC, LOXHD1
inner ear receptor stereocilium organization (GO:0060122)	6.47	8	LHFPL5, ATP2B2, CDH23, PCDH15, CLIC5, STRC, MYO7A, GRXCR1
single-organism transport (GO:0044765)	2.18	8	OTOF, SLC26A4, SLC26A5, PNPT1, KCNJ10, HGF, ATP2B2, MYO7A
regulation of signaling (GO:0023051)	1.72	8	S1PR2, HGF, KCNJ10, RDX, ILDR1, EPS8, DCDC2, ATP2B2
regulation of molecular function (GO:0065009)	1.78	8	ADCY1, S1PR2, HGF, RDX, SERPINB6, ELMOD3, TBC1D24, GRXCR1
regulation of cell communication (GO:0010646)	1.73	8	S1PR2, HGF, KCNJ10, RDX, ILDR1, EPS8, DCDC2, ATP2B2
response to organic substance (GO:0010033)	2.2	8	ADCY1, HGF, RDX, GJB6, CIB2, SLC26A5, PNPT1, GJB2
single-organism localization (GO:1902578)	2.09	8	OTOF, SLC26A4, SLC26A5, PNPT1, KCNJ10, HGF, ATP2B2, MYO7A
regulation of organelle organization (GO:0033043)	2.72	7	HGF, RDX, ESPN, EPS8, TRIOBP, DCDC2, TBC1D24
regulation of transport (GO:0051049)	2.24	7	MYO6, KCNJ10, RDX, ILDR1, SLC26A5, CLIC5, ATP2B2
ion homeostasis (GO:0050801)	3.42	7	KCNJ10, SLC26A4, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3
regulation of response to stimulus (GO:0048583)	1.54	7	S1PR2, HGF, RDX, EPS8, MET, PNPT1, DCDC2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	7	ADCY1, KARS, PNPT1, CLIC5, ATP2B2, ESRRB, FOXI1
cellular response to chemical stimulus (GO:0070887)	2.57	7	ADCY1, HGF, RDX, GJB6, CIB2, PNPT1, GJB2
inorganic ion homeostasis (GO:0098771)	3.43	7	KCNJ10, SLC26A4, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3
organic cyclic compound metabolic process (GO:1901360)	1.26	7	ADCY1, KARS, LRTOMT, PNPT1, ATP2B2, ESRRB, FOXI1
detection of mechanical stimulus (GO:0050982)	5.94	7	LHFPL5, ATP2B2, TMC1, PTPRQ, PCDH15, STRC, LOXHD1
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	7	HGF, RDX, EPS8, SLC26A5, TRIOBP, DCDC2, TBC1D24
inorganic ion transmembrane transport (GO:0098660)	3.38	7	SLC26A4, KCNJ10, TMC1, SLC26A5, CLIC5, ATP2B2, LOXHD1
embryonic morphogenesis (GO:0048598)	3.72	7	MYO15A, MYO7A, GJB6, TMIE, PTPRQ, ATP2B2, FOXI1
detection of external stimulus (GO:0009581)	4.98	7	LHFPL5, ATP2B2, TMC1, PTPRQ, PCDH15, STRC, LOXHD1
detection of abiotic stimulus (GO:0009582)	4.96	7	LHFPL5, ATP2B2, TMC1, PTPRQ, PCDH15, STRC, LOXHD1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	7	ADCY1, HGF, MYO6, MET, PNPT1, ESRRB, FOXI1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	7	ADCY1, HGF, MYO6, MET, PNPT1, ESRRB, FOXI1
cellular aromatic compound metabolic process (GO:0006725)	1.3	7	ADCY1, KARS, LRTOMT, PNPT1, ATP2B2, ESRRB, FOXI1
ion transmembrane transport (GO:0034220)	3.08	7	SLC26A4, KCNJ10, TMC1, SLC26A5, CLIC5, ATP2B2, LOXHD1
response to stress (GO:0006950)	1.8	7	MYO6, SERPINB6, SLC26A5, PNPT1, DCDC2, MSRB3, GJB2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	7	ADCY1, HGF, MYO6, MET, PNPT1, ESRRB, FOXI1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	7	ADCY1, HGF, MYO6, MET, PNPT1, ESRRB, FOXI1
cation homeostasis (GO:0055080)	3.46	7	KCNJ10, SLC26A4, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3
cellular chemical homeostasis (GO:0055082)	3.4	7	SLC26A4, GJB6, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3
detection of stimulus (GO:0051606)	3.22	7	LHFPL5, ATP2B2, TMC1, PTPRQ, PCDH15, STRC, LOXHD1
regulation of cell morphogenesis (GO:0022604)	3.4	6	RDX, EPS8, SLC26A5, TRIOBP, DCDC2, TBC1D24
positive regulation of biosynthetic process (GO:0009891)	2.29	6	ADCY1, HGF, MYO6, MET, ESRRB, FOXI1
regulation of cellular biosynthetic process (GO:0031326)	1.38	6	ADCY1, HGF, MYO6, MET, ESRRB, FOXI1
auditory receptor cell stereocilium organization (GO:0060088)	7.24	6	LHFPL5, STRC, PCDH15, CLIC5, ATP2B2, MYO7A
positive regulation of gene expression (GO:0010628)	2.35	6	MYO6, HGF, RDX, MET, ESRRB, FOXI1
detection of stimulus involved in sensory perception (GO:0050906)	3.46	6	LHFPL5, STRC, TMC1, PTPRQ, PCDH15, ATP2B2
cellular component morphogenesis (GO:0032989)	3.5	6	ADCY1, HGF, MET, PNPT1, PTPRQ, ATP2B2
regulation of cell projection organization (GO:0031344)	3.38	6	HGF, RDX, TBC1D24, ESPN, DCDC2, USH1C
cellular protein metabolic process (GO:0044267)	1.63	6	KARS, MET, PTPRQ, MYO3A, TRIOBP, MSRB3
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	6	ADCY1, HGF, MYO6, MET, ESRRB, FOXI1
regulation of anatomical structure size (GO:0090066)	3.78	6	RDX, EPS8, SLC26A5, TRIOBP, ATP2B2, USH1C
cellular response to organic substance (GO:0071310)	2.78	6	ADCY1, HGF, RDX, GJB6, CIB2, PNPT1
animal organ development (GO:0048513)	2.53	6	FAM65B, HGF, COL11A2, GJB2, ESRRB, GJB3
organic substance transport (GO:0071702)	2.15	6	MYO6, SLC26A4, SLC26A5, PNPT1, KCNJ10, MYO7A
biological adhesion (GO:0022610)	2.81	6	OTOA, TECTA, CDH23, CLDN14, PCDH15, STRC
regulation of gene expression (GO:0010468)	1.37	6	HGF, MYO6, RDX, MET, ESRRB, FOXI1
detection of mechanical stimulus involved in sensory perception (GO:0050974)	6.43	6	LHFPL5, STRC, TMC1, PTPRQ, PCDH15, ATP2B2
nucleobase-containing compound metabolic process (GO:0006139)	1.35	6	ADCY1, KARS, PNPT1, ATP2B2, ESRRB, FOXI1
regulation of biosynthetic process (GO:0009889)	1.37	6	ADCY1, HGF, MYO6, MET, ESRRB, FOXI1
cellular ion homeostasis (GO:0006873)	3.57	6	SLC26A4, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3
detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	7.09	6	LHFPL5, STRC, TMC1, PTPRQ, PCDH15, ATP2B2
sensory perception of light stimulus (GO:0050953)	4.4	6	KCNJ10, CDH23, MYO3A, PCDH15, MYO7A, USH1C
cellular cation homeostasis (GO:0030003)	3.6	6	SLC26A4, CDH23, CIB2, SLC26A5, ATP2B2, TMPRSS3
cell adhesion (GO:0007155)	2.82	6	OTOA, TECTA, CDH23, CLDN14, PCDH15, STRC
heterocycle metabolic process (GO:0046483)	1.31	6	ADCY1, KARS, PNPT1, ATP2B2, ESRRB, FOXI1
regulation of hydrolase activity (GO:0051336)	2.53	6	HGF, RDX, SERPINB6, ELMOD3, TBC1D24, GRXCR1
inner ear morphogenesis (GO:0042472)	5.62	6	MYO15A, MYO7A, TMIE, PTPRQ, ATP2B2, FOXI1
organonitrogen compound metabolic process (GO:1901564)	2.32	6	ADCY1, HGF, KARS, LRTOMT, CLIC5, ATP2B2
vesicle-mediated transport (GO:0016192)	2.72	6	MYO6, OTOF, ILDR1, HGF, MYO7A, TMPRSS3
regulation of RNA metabolic process (GO:0051252)	1.52	6	HGF, MYO6, MET, PNPT1, ESRRB, FOXI1
positive regulation of RNA metabolic process (GO:0051254)	2.51	6	HGF, MYO6, MET, PNPT1, ESRRB, FOXI1
regulation of cellular component biogenesis (GO:0044087)	3.08	6	RDX, ESPN, EPS8, TRIOBP, DCDC2, TBC1D24
phosphate-containing compound metabolic process (GO:0006796)	2.16	6	ADCY1, KARS, MET, MYO3A, PTPRQ, ATP2B2
phosphorus metabolic process (GO:0006793)	2.15	6	ADCY1, KARS, MET, MYO3A, PTPRQ, ATP2B2
cell cycle process (GO:0022402)	2.75	6	HGF, PNPT1, EPS8, TRIOBP, SYNE4, USH1C
regulation of cellular component size (GO:0032535)	4.21	6	RDX, EPS8, SLC26A5, TRIOBP, ATP2B2, USH1C
protein localization (GO:0008104)	2.36	5	RDX, CLIC5, USH1C, MYO6, MYO7A
macromolecular complex subunit organization (GO:0043933)	2.14	5	SLC26A5, PNPT1, USH1C, CLDN14, COL11A2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	5	MET, MYO6, ESRRB, FOXI1, HGF
regulation of RNA biosynthetic process (GO:2001141)	1.55	5	MET, MYO6, ESRRB, FOXI1, HGF
positive regulation of response to stimulus (GO:0048584)	2.18	5	S1PR2, MET, DCDC2, EPS8, HGF
negative regulation of cellular component organization (GO:0051129)	3.35	5	RDX, TRIOBP, EPS8, ESPN, HGF
movement of cell or subcellular component (GO:0006928)	2.61	5	EPS8, MYO6, DCDC2, MYO7A, HGF
positive regulation of signaling (GO:0023056)	2.41	5	S1PR2, DCDC2, ILDR1, EPS8, HGF
small molecule metabolic process (GO:0044281)	2.38	5	ADCY1, OTOG, OTOGL, ATP2B2, KARS
intracellular signal transduction (GO:0035556)	2.39	5	ADCY1, RDX, DCDC2, EPS8, MYO6
positive regulation of cell communication (GO:0010647)	2.41	5	S1PR2, ILDR1, DCDC2, EPS8, HGF
positive regulation of catalytic activity (GO:0043085)	2.4	5	S1PR2, ADCY1, ELMOD3, TBC1D24, HGF
response to endogenous stimulus (GO:0009719)	2.79	5	ADCY1, RDX, GJB2, SLC26A5, CIB2
establishment of localization in cell (GO:0051649)	2.47	5	SYNE4, MYO6, MYO7A, KCNJ10, OTOF
regulation of signal transduction (GO:0009966)	1.84	5	S1PR2, RDX, DCDC2, EPS8, HGF
regulation of protein metabolic process (GO:0051246)	1.93	5	S1PR2, ADCY1, SERPINB6, HGF, RDX
single-organism organelle organization (GO:1902589)	2.68	5	S1PR2, PNPT1, PCDH15, TRIOBP, EPS8
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	5	MET, MYO6, ESRRB, FOXI1, HGF
positive regulation of molecular function (GO:0044093)	2.23	5	S1PR2, ADCY1, ELMOD3, TBC1D24, HGF
macromolecule localization (GO:0033036)	2.34	5	RDX, CLIC5, USH1C, MYO6, MYO7A
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	5	MET, MYO6, ESRRB, HGF, FOXI1
response to oxygen-containing compound (GO:1901700)	2.57	5	ADCY1, SLC26A5, GJB2, GJB6, CIB2
actin filament-based process (GO:0030029)	3.94	5	S1PR2, TRIOBP, EPS8, MYO6, MYO7A
cation transport (GO:0006812)	3.11	5	LOXHD1, TMC1, CDH23, KCNJ10, ATP2B2
visual perception (GO:0007601)	4.41	5	PCDH15, MYO7A, CDH23, KCNJ10, MYO3A
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	5	MET, MYO6, ESRRB, HGF, FOXI1
metal ion transport (GO:0030001)	3.36	5	LOXHD1, CDH23, TMC1, ATP2B2, KCNJ10
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	5	MET, MYO6, ESRRB, HGF, FOXI1
metal ion homeostasis (GO:0055065)	3.61	5	TMPRSS3, CDH23, ATP2B2, CIB2, KCNJ10
locomotion (GO:0040011)	2.91	5	MET, EPS8, DCDC2, ATP2B2, HGF
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	S1PR2, RDX, ADCY1, SERPINB6, HGF
protein complex subunit organization (GO:0071822)	2.6	5	SLC26A5, PNPT1, USH1C, CLDN14, COL11A2
mitotic cell cycle process (GO:1903047)	3.12	5	SYNE4, EPS8, USH1C, TRIOBP, HGF
single-organism behavior (GO:0044708)	3.79	5	ADCY1, OTOG, PCDH15, EPS8, KCNJ10
negative regulation of organelle organization (GO:0010639)	4.07	5	RDX, ESPN, EPS8, HGF, TRIOBP
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	5	MET, MYO6, ESRRB, HGF, FOXI1
regulation of transcription, DNA-templated (GO:0006355)	1.56	5	MET, MYO6, ESRRB, HGF, FOXI1
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	5	MET, MYO6, ESRRB, HGF, FOXI1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	5	MET, FOXI1, ESRRB, MYO6, HGF
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	5	MET, FOXI1, ESRRB, MYO6, HGF
regulation of membrane potential (GO:0042391)	3.89	4	S1PR2, SLC26A5, SLC26A4, KCNJ10
regulation of phosphate metabolic process (GO:0019220)	2.35	4	S1PR2, ADCY1, GRXCR1, HGF
nucleic acid metabolic process (GO:0090304)	1.46	4	PNPT1, ESRRB, KARS, FOXI1
cellular biosynthetic process (GO:0044249)	1.37	4	ADCY1, ESRRB, KARS, FOXI1
regulation of cell projection assembly (GO:0060491)	4.66	4	RDX, DCDC2, ESPN, TBC1D24
neuromuscular process (GO:0050905)	5.27	4	PTPRQ, CLIC5, PCDH15, ATP2B2
regulation of cell differentiation (GO:0045595)	2.42	4	S1PR2, TRIOBP, PTPRQ, HGF
organic cyclic compound biosynthetic process (GO:1901362)	1.66	4	ADCY1, ESRRB, KARS, FOXI1
negative regulation of catalytic activity (GO:0043086)	3.0	4	RDX, SERPINB6, GRXCR1, HGF
response to organic cyclic compound (GO:0014070)	3.07	4	ADCY1, SLC26A5, GJB2, CIB2
organic substance biosynthetic process (GO:1901576)	1.34	4	ADCY1, ESRRB, KARS, FOXI1
anion transport (GO:0006820)	3.71	4	SLC26A5, CLIC5, KCNJ10, SLC26A4
negative regulation of hydrolase activity (GO:0051346)	3.74	4	RDX, SERPINB6, GRXCR1, HGF
positive regulation of signal transduction (GO:0009967)	2.5	4	S1PR2, DCDC2, EPS8, HGF
divalent metal ion transport (GO:0070838)	4.15	4	LOXHD1, CDH23, TMC1, ATP2B2
negative regulation of cytoskeleton organization (GO:0051494)	5.01	4	RDX, TRIOBP, ESPN, EPS8
regulation of cytoskeleton organization (GO:0051493)	3.72	4	RDX, ESPN, TRIOBP, EPS8
positive regulation of protein metabolic process (GO:0051247)	2.43	4	S1PR2, ADCY1, HGF, RDX
macromolecular complex assembly (GO:0065003)	2.55	4	SLC26A5, PNPT1, USH1C, CLDN14
inorganic cation transmembrane transport (GO:0098662)	3.55	4	LOXHD1, TMC1, ATP2B2, KCNJ10
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	4	S1PR2, RDX, ADCY1, HGF
regulation of ion transport (GO:0043269)	3.4	4	SLC26A5, CLIC5, KCNJ10, ATP2B2
negative regulation of molecular function (GO:0044092)	2.74	4	RDX, SERPINB6, GRXCR1, HGF
cellular localization (GO:0051641)	2.32	4	SYNE4, MYO6, MYO7A, OTOF
epithelial cell development (GO:0002064)	4.92	4	RDX, TMC1, LRTOMT, MARVELD2
heterocycle biosynthetic process (GO:0018130)	1.7	4	ADCY1, ESRRB, KARS, FOXI1
neuron development (GO:0048666)	4.8	4	TMC1, MYO7A, LRTOMT, GRXCR1
cellular response to stress (GO:0033554)	2.51	4	PNPT1, SERPINB6, GJB2, MYO6
adult behavior (GO:0030534)	4.79	4	OTOG, PCDH15, EPS8, KCNJ10
cellular metal ion homeostasis (GO:0006875)	3.75	4	TMPRSS3, CDH23, ATP2B2, CIB2
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	4	ADCY1, ESRRB, KARS, FOXI1
equilibrioception (GO:0050957)	7.94	4	CDH23, PCDH15, USH1C, MYO7A
protein complex assembly (GO:0006461)	2.78	4	SLC26A5, PNPT1, USH1C, CLDN14
calcium ion transport (GO:0006816)	4.33	4	LOXHD1, CDH23, TMC1, ATP2B2
cellular protein modification process (GO:0006464)	1.79	4	MET, PTPRQ, TRIOBP, MYO3A
regulation of phosphorus metabolic process (GO:0051174)	2.35	4	S1PR2, ADCY1, GRXCR1, HGF
reproductive process (GO:0022414)	2.55	4	ESRRB, GJB3, CLIC5, GJB2
macromolecule modification (GO:0043412)	1.73	4	MET, TRIOBP, PTPRQ, MYO3A
regulation of locomotion (GO:0040012)	3.12	4	MET, RDX, SLC26A5, HGF
monovalent inorganic cation homeostasis (GO:0055067)	4.93	4	SLC26A5, TMPRSS3, SLC26A4, KCNJ10
regulation of multicellular organismal process (GO:0051239)	1.87	4	S1PR2, MET, ATP2B2, HGF
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	4	ADCY1, ESRRB, KARS, FOXI1
endocytosis (GO:0006897)	3.69	4	TMPRSS3, ILDR1, MYO6, MYO7A
adult locomotory behavior (GO:0008344)	5.3	4	PCDH15, OTOG, EPS8, KCNJ10
cell morphogenesis (GO:0000902)	4.35	4	MET, PTPRQ, ATP2B2, HGF
RNA metabolic process (GO:0016070)	1.59	4	PNPT1, ESRRB, KARS, FOXI1
positive regulation of cellular component movement (GO:0051272)	3.71	4	MET, RDX, SLC26A5, HGF
inner ear development (GO:0048839)	5.76	4	PCDH15, GJB6, MYO7A, ATP2B2
regulation of cellular component movement (GO:0051270)	3.08	4	MET, SLC26A5, HGF, RDX
divalent inorganic cation transport (GO:0072511)	4.13	4	LOXHD1, CDH23, TMC1, ATP2B2
positive regulation of locomotion (GO:0040017)	3.71	4	MET, SLC26A5, HGF, RDX
response to hormone (GO:0009725)	3.33	4	ADCY1, SLC26A5, GJB2, RDX
biosynthetic process (GO:0009058)	1.32	4	ADCY1, ESRRB, KARS, FOXI1
cell communication (GO:0007154)	3.04	4	GJB6, GJB3, GJB2, HGF
protein modification process (GO:0036211)	1.79	4	MET, PTPRQ, TRIOBP, MYO3A
regulation of cell motility (GO:2000145)	3.16	4	MET, SLC26A5, HGF, RDX
positive regulation of cell motility (GO:2000147)	3.74	4	MET, RDX, SLC26A5, HGF
organophosphate metabolic process (GO:0019637)	3.04	4	ADCY1, PTPRQ, ATP2B2, KARS
aromatic compound biosynthetic process (GO:0019438)	1.7	4	ADCY1, ESRRB, KARS, FOXI1
cation transmembrane transport (GO:0098655)	3.43	4	LOXHD1, TMC1, KCNJ10, ATP2B2
photoreceptor cell maintenance (GO:0045494)	6.17	4	CDH23, PCDH15, USH1C, CIB2
negative regulation of response to stimulus (GO:0048585)	2.52	3	S1PR2, MET, HGF
activation of protein kinase activity (GO:0032147)	4.08	3	S1PR2, ADCY1, HGF
regulation of actin polymerization or depolymerization (GO:0008064)	4.65	3	RDX, TRIOBP, EPS8
chloride transport (GO:0006821)	5.13	3	SLC26A5, CLIC5, SLC26A4
calcium ion homeostasis (GO:0055074)	3.97	3	CDH23, ATP2B2, CIB2
cell surface receptor signaling pathway (GO:0007166)	2.09	3	MET, EPS8, HGF
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	3	MET, EPS8, HGF
regulation of ion transmembrane transport (GO:0034765)	3.77	3	SLC26A5, CLIC5, KCNJ10
regulation of transmembrane transport (GO:0034762)	3.74	3	SLC26A5, CLIC5, KCNJ10
positive regulation of cell development (GO:0010720)	3.57	3	S1PR2, TRIOBP, HGF
epithelial cell differentiation (GO:0030855)	3.98	3	SYNE4, PCDH15, MYO7A
regulation of cell proliferation (GO:0042127)	2.41	3	S1PR2, GJB6, HGF
cell-substrate adhesion (GO:0031589)	4.75	3	OTOA, STRC, TECTA
positive regulation of transport (GO:0051050)	2.9	3	RDX, ILDR1, ATP2B2
regulation of protein kinase activity (GO:0045859)	3.15	3	S1PR2, ADCY1, HGF
organic anion transport (GO:0015711)	4.07	3	SLC26A5, SLC26A4, KCNJ10
negative regulation of protein depolymerization (GO:1901880)	5.7	3	RDX, TRIOBP, EPS8
establishment of protein localization (GO:0045184)	2.53	3	RDX, MYO6, MYO7A
developmental process involved in reproduction (GO:0003006)	3.36	3	GJB3, ESRRB, GJB2
regulation of cell size (GO:0008361)	5.42	3	RDX, SLC26A5, ATP2B2
regulation of cell shape (GO:0008360)	4.77	3	RDX, SLC26A5, EPS8
response to metal ion (GO:0010038)	3.91	3	ADCY1, SLC26A5, PCDH15
response to inorganic substance (GO:0010035)	3.56	3	SLC26A5, ADCY1, PCDH15
cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)	4.39	3	CLDN14, CDH23, PCDH15
multi-organism process (GO:0051704)	2.65	3	GJB2, CLIC5, KARS
regulation of phosphorylation (GO:0042325)	2.5	3	S1PR2, ADCY1, HGF
single organism signaling (GO:0044700)	3.25	3	OTOA, GJB2, HGF
positive regulation of phosphorylation (GO:0042327)	2.9	3	S1PR2, ADCY1, HGF
single organism reproductive process (GO:0044702)	2.73	3	GJB3, ESRRB, GJB2
cell motility (GO:0048870)	3.02	3	DCDC2, EPS8, HGF
calcium ion transmembrane transport (GO:0070588)	4.67	3	LOXHD1, TMC1, ATP2B2
negative regulation of metabolic process (GO:0009892)	1.93	3	SERPINB6, GRXCR1, HGF
positive regulation of kinase activity (GO:0033674)	3.54	3	S1PR2, ADCY1, HGF
regulation of protein depolymerization (GO:1901879)	5.44	3	RDX, TRIOBP, EPS8
regulation of cell migration (GO:0030334)	3.23	3	MET, RDX, HGF
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	3	MET, EPS8, HGF
cell morphogenesis involved in differentiation (GO:0000904)	4.67	3	MET, PTPRQ, HGF
positive regulation of transferase activity (GO:0051347)	3.31	3	S1PR2, ADCY1, HGF
positive regulation of phosphate metabolic process (GO:0045937)	2.78	3	S1PR2, ADCY1, HGF
regulation of kinase activity (GO:0043549)	3.07	3	S1PR2, ADCY1, HGF
inorganic anion transmembrane transport (GO:0098661)	5.04	3	SLC26A5, CLIC5, SLC26A4
cell migration (GO:0016477)	3.12	3	DCDC2, EPS8, HGF
positive regulation of cellular component organization (GO:0051130)	2.68	3	TRIOBP, ESPN, HGF
organ morphogenesis (GO:0009887)	3.55	3	GJB6, COL11A2, MYO7A
cell-cell adhesion (GO:0098609)	3.34	3	CLDN14, CDH23, PCDH15
regulation of actin cytoskeleton organization (GO:0032956)	4.09	3	RDX, TRIOBP, EPS8
regulation of protein complex assembly (GO:0043254)	3.83	3	RDX, TRIOBP, EPS8
regulation of intracellular signal transduction (GO:1902531)	2.31	3	S1PR2, RDX, HGF
secretion (GO:0046903)	3.38	3	ATP2B2, HGF, OTOF
regulation of response to stress (GO:0080134)	2.53	3	MET, PNPT1, HGF
regulation of cellular response to stress (GO:0080135)	3.4	3	MET, PNPT1, HGF
regulation of transferase activity (GO:0051338)	2.88	3	S1PR2, ADCY1, HGF
cell-matrix adhesion (GO:0007160)	5.13	3	OTOA, STRC, TECTA
nucleoside phosphate metabolic process (GO:0006753)	3.71	3	ADCY1, ATP2B2, KARS
inner ear receptor cell differentiation (GO:0060113)	7.02	3	PCDH15, MYO7A, ATP2B2
actin filament bundle organization (GO:0061572)	5.82	3	ESPN, PCDH15, EPS8
modulation of synaptic transmission (GO:0050804)	4.09	3	S1PR2, KCNJ10, ATP2B2
inner ear receptor cell development (GO:0060119)	6.96	3	TMC1, GRXCR1, LRTOMT
signaling (GO:0023052)	3.25	3	OTOA, GJB2, HGF
cellular macromolecule biosynthetic process (GO:0034645)	1.66	3	ESRRB, KARS, FOXI1
regulation of protein complex disassembly (GO:0043244)	5.27	3	RDX, TRIOBP, EPS8
regulation of GTPase activity (GO:0043087)	3.21	3	RDX, ELMOD3, TBC1D24
negative regulation of protein complex disassembly (GO:0043242)	5.65	3	RDX, TRIOBP, EPS8
divalent inorganic cation homeostasis (GO:0072507)	3.9	3	CDH23, ATP2B2, CIB2
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	3	CDH23, ATP2B2, CIB2
neuromuscular process controlling balance (GO:0050885)	5.88	3	PTPRQ, CLIC5, ATP2B2
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	3	S1PR2, ADCY1, HGF
regulation of cell development (GO:0060284)	3.01	3	S1PR2, TRIOBP, HGF
regulation of protein polymerization (GO:0032271)	4.57	3	RDX, TRIOBP, EPS8
negative regulation of protein polymerization (GO:0032272)	5.72	3	RDX, TRIOBP, EPS8
regulation of protein modification process (GO:0031399)	2.32	3	S1PR2, ADCY1, HGF
actin filament capping (GO:0051693)	6.26	3	RDX, TRIOBP, EPS8
cellular response to endogenous stimulus (GO:0071495)	3.33	3	ADCY1, RDX, CIB2
cell proliferation (GO:0008283)	3.23	3	MET, EPS8, HGF
cellular calcium ion homeostasis (GO:0006874)	4.01	3	CDH23, ATP2B2, CIB2
regulation of actin filament-based process (GO:0032970)	3.97	3	RDX, TRIOBP, EPS8
actin filament bundle assembly (GO:0051017)	5.88	3	ESPN, PCDH15, EPS8
positive regulation of cell differentiation (GO:0045597)	3.01	3	S1PR2, TRIOBP, HGF
cellular monovalent inorganic cation homeostasis (GO:0030004)	5.19	3	TMPRSS3, SLC26A5, SLC26A4
response to oxidative stress (GO:0006979)	3.9	3	PNPT1, GJB2, MSRB3
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	3	ADCY1, ATP2B2, KARS
positive regulation of developmental process (GO:0051094)	2.77	3	S1PR2, TRIOBP, HGF
carbohydrate derivative metabolic process (GO:1901135)	3.07	3	ADCY1, ATP2B2, HGF
response to drug (GO:0042493)	3.71	3	ADCY1, SLC26A5, MYO6
mechanoreceptor differentiation (GO:0042490)	6.78	3	PCDH15, MYO7A, ATP2B2
system development (GO:0048731)	2.92	3	GJB2, DCDC2, COL11A2
positive regulation of protein kinase activity (GO:0045860)	3.61	3	S1PR2, ADCY1, HGF
positive regulation of protein modification process (GO:0031401)	2.7	3	S1PR2, ADCY1, HGF
cell projection assembly (GO:0030031)	4.19	3	S1PR2, RDX, PCDH15
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	SERPINB6, GRXCR1, HGF
actin cytoskeleton organization (GO:0030036)	4.1	3	S1PR2, TRIOBP, EPS8
multicellular organism development (GO:0007275)	2.54	3	GJB3, FAM65B, FOXI1
regulation of actin filament length (GO:0030832)	4.65	3	RDX, TRIOBP, EPS8
regulation of actin filament polymerization (GO:0030833)	4.76	3	RDX, TRIOBP, EPS8
regulation of actin filament depolymerization (GO:0030834)	5.88	3	RDX, TRIOBP, EPS8
negative regulation of actin filament depolymerization (GO:0030835)	6.17	3	RDX, TRIOBP, EPS8
negative regulation of actin filament polymerization (GO:0030837)	5.94	3	RDX, TRIOBP, EPS8
response to lipid (GO:0033993)	3.11	3	ADCY1, GJB2, GJB6
regulation of organelle assembly (GO:1902115)	4.7	3	RDX, DCDC2, TBC1D24
inorganic anion transport (GO:0015698)	4.77	3	SLC26A5, CLIC5, SLC26A4
positive regulation of cell migration (GO:0030335)	3.77	3	MET, RDX, HGF
negative regulation of protein complex assembly (GO:0031333)	5.07	3	RDX, TRIOBP, EPS8
neuron differentiation (GO:0030182)	4.17	3	PCDH15, MYO7A, ATP2B2
chloride transmembrane transport (GO:1902476)	5.22	3	SLC26A5, CLIC5, SLC26A4
macromolecule biosynthetic process (GO:0009059)	1.61	3	ESRRB, KARS, FOXI1
nucleotide metabolic process (GO:0009117)	3.73	3	ADCY1, ATP2B2, KARS
cochlea development (GO:0090102)	6.64	3	SLC26A5, OTOF, ATP2B2
catabolic process (GO:0009056)	2.38	3	PNPT1, COL11A2, LRTOMT
carboxylic acid transport (GO:0046942)	4.28	3	SLC26A5, SLC26A4, KCNJ10
cellular response to oxygen-containing compound (GO:1901701)	3.22	3	ADCY1, GJB6, CIB2
actin filament organization (GO:0007015)	4.54	3	ESPN, PCDH15, EPS8
cytoskeleton organization (GO:0007010)	3.22	3	S1PR2, TRIOBP, EPS8
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	3	CDH23, ATP2B2, CIB2
anion transmembrane transport (GO:0098656)	4.51	3	SLC26A5, CLIC5, SLC26A4
regulation of protein phosphorylation (GO:0001932)	2.57	3	S1PR2, ADCY1, HGF
positive regulation of protein phosphorylation (GO:0001934)	2.95	3	S1PR2, ADCY1, HGF
regulation of protein localization (GO:0032880)	2.88	2	RDX, SLC26A4
reflex (GO:0060004)	6.68	2	TMC1, PCDH15
regulation of secretion (GO:0051046)	3.2	2	ILDR1, MYO6
nucleotide biosynthetic process (GO:0009165)	4.49	2	ADCY1, KARS
regulation of neurotransmitter levels (GO:0001505)	4.77	2	LRTOMT, KCNJ10
sulfate transport (GO:0008272)	7.09	2	SLC26A5, SLC26A4
regulated exocytosis (GO:0045055)	4.44	2	OTOF, HGF
establishment of vesicle localization (GO:0051650)	4.91	2	OTOF, MYO7A
positive regulation of cell projection organization (GO:0031346)	3.99	2	ESPN, HGF
single-organism biosynthetic process (GO:0044711)	2.8	2	ADCY1, KARS
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	SERPINB6, HGF
negative regulation of signal transduction (GO:0009968)	2.75	2	S1PR2, HGF
negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	6.96	2	MET, HGF
regulation of hydrogen peroxide-induced cell death (GO:1903205)	6.78	2	MET, HGF
negative regulation of oxidative stress-induced cell death (GO:1903202)	6.23	2	MET, HGF
regulation of oxidative stress-induced cell death (GO:1903201)	5.9	2	MET, HGF
columnar/cuboidal epithelial cell development (GO:0002066)	6.29	2	TMC1, LRTOMT
columnar/cuboidal epithelial cell differentiation (GO:0002065)	5.84	2	PCDH15, MYO7A
chemotaxis (GO:0006935)	4.04	2	MET, HGF
negative regulation of cell death (GO:0060548)	2.95	2	MET, HGF
oxalate transport (GO:0019532)	7.24	2	SLC26A5, SLC26A4
response to calcium ion (GO:0051592)	4.98	2	ADCY1, PCDH15
actin filament-based movement (GO:0030048)	5.54	2	MYO6, MYO7A
regulation of proteolysis (GO:0030162)	3.2	2	SERPINB6, HGF
oxidation-reduction process (GO:0055114)	2.91	2	MSRB3, GRXCR1
multi-organism reproductive process (GO:0044703)	4.82	2	GJB2, CLIC5
organonitrogen compound biosynthetic process (GO:1901566)	2.85	2	ADCY1, KARS
negative regulation of signaling (GO:0023057)	2.65	2	S1PR2, HGF
regulation of autophagy (GO:0010506)	4.21	2	MET, HGF
response to organonitrogen compound (GO:0010243)	3.2	2	ADCY1, CIB2
multi-multicellular organism process (GO:0044706)	4.92	2	GJB2, CLIC5
purine nucleotide metabolic process (GO:0006163)	4.09	2	ADCY1, ATP2B2
female pregnancy (GO:0007565)	5.08	2	GJB2, CLIC5
aromatic compound catabolic process (GO:0019439)	3.79	2	PNPT1, LRTOMT
pentose metabolic process (GO:0019321)	7.16	2	OTOGL, OTOG
regulation of catabolic process (GO:0009894)	3.52	2	RDX, PNPT1
regulation of synaptic plasticity (GO:0048167)	4.78	2	KCNJ10, ATP2B2
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	S1PR2, HGF
mitotic nuclear division (GO:0007067)	4.05	2	TRIOBP, HGF
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	S1PR2, HGF
nucleic acid-templated transcription (GO:0097659)	1.91	2	ESRRB, FOXI1
hair cell differentiation (GO:0035315)	7.02	2	PCDH15, MYO7A
organic substance catabolic process (GO:1901575)	2.45	2	PNPT1, LRTOMT
establishment of organelle localization (GO:0051656)	4.15	2	OTOF, MYO7A
positive regulation of GTPase activity (GO:0043547)	3.28	2	ELMOD3, TBC1D24
positive regulation of hydrolase activity (GO:0051345)	2.91	2	ELMOD3, TBC1D24
regulation of pH (GO:0006885)	5.24	2	SLC26A5, SLC26A4
intracellular protein transport (GO:0006886)	3.2	2	MYO6, MYO7A
exocytosis (GO:0006887)	4.11	2	OTOF, HGF
auditory receptor cell development (GO:0060117)	7.78	2	TMC1, LRTOMT
regulation of cilium assembly (GO:1902017)	5.7	2	DCDC2, TBC1D24
organic cyclic compound catabolic process (GO:1901361)	3.73	2	PNPT1, LRTOMT
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	S1PR2, ADCY1
purine ribonucleotide metabolic process (GO:0009150)	4.16	2	ADCY1, ATP2B2
tissue development (GO:0009888)	3.27	2	GJB2, ATP2B2
adult walking behavior (GO:0007628)	6.23	2	PCDH15, KCNJ10
positive regulation of MAPK cascade (GO:0043410)	3.57	2	S1PR2, HGF
single-organism carbohydrate metabolic process (GO:0044723)	3.42	2	OTOGL, OTOG
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	S1PR2, HGF
hepatocyte growth factor receptor signaling pathway (GO:0048012)	7.53	2	MET, HGF
organophosphate biosynthetic process (GO:0090407)	3.67	2	ADCY1, KARS
taxis (GO:0042330)	4.03	2	MET, HGF
intracellular transport (GO:0046907)	2.67	2	MYO6, MYO7A
response to nitrogen compound (GO:1901698)	3.12	2	ADCY1, CIB2
receptor-mediated endocytosis (GO:0006898)	4.31	2	TMPRSS3, ILDR1
nucleoside phosphate biosynthetic process (GO:1901293)	4.47	2	ADCY1, KARS
peptide metabolic process (GO:0006518)	3.44	2	CLIC5, KARS
regulation of hydrogen peroxide-mediated programmed cell death (GO:1901298)	7.65	2	MET, HGF
negative regulation of hydrogen peroxide-mediated programmed cell death (GO:1901299)	7.94	2	MET, HGF
positive regulation of catabolic process (GO:0009896)	3.94	2	RDX, PNPT1
sulfate transmembrane transport (GO:1902358)	7.24	2	SLC26A5, SLC26A4
RNA biosynthetic process (GO:0032774)	1.84	2	ESRRB, FOXI1
regulation of response to external stimulus (GO:0032101)	3.06	2	MET, HGF
regulation of synapse structure or activity (GO:0050803)	4.77	2	KCNJ10, ATP2B2
phosphorylation (GO:0016310)	2.63	2	MET, MYO3A
regulation of cell adhesion (GO:0030155)	3.27	2	RDX, TRIOBP
bicarbonate transport (GO:0015701)	5.97	2	SLC26A5, SLC26A4
monosaccharide metabolic process (GO:0005996)	4.57	2	OTOGL, OTOG
cellular catabolic process (GO:0044248)	2.62	2	PNPT1, LRTOMT
positive regulation of MAP kinase activity (GO:0043406)	4.39	2	S1PR2, HGF
regulation of MAP kinase activity (GO:0043405)	3.95	2	S1PR2, HGF
cell-cell junction assembly (GO:0007043)	5.42	2	GJB2, MARVELD2
negative regulation of cell communication (GO:0010648)	2.66	2	S1PR2, HGF
regulation of intracellular pH (GO:0051453)	5.44	2	SLC26A5, SLC26A4
ribonucleotide metabolic process (GO:0009259)	4.11	2	ADCY1, ATP2B2
regulation of MAPK cascade (GO:0043408)	3.22	2	S1PR2, HGF
negative regulation of protein metabolic process (GO:0051248)	2.82	2	SERPINB6, HGF
homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	4.68	2	PCDH15, CDH23
negative regulation of endopeptidase activity (GO:0010951)	4.26	2	SERPINB6, HGF
regulation of system process (GO:0044057)	3.53	2	ATP2B2, HGF
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	MET, HGF
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	GRXCR1, HGF
nuclear division (GO:0000280)	3.85	2	TRIOBP, HGF
neuroepithelial cell differentiation (GO:0060563)	6.51	2	PCDH15, MYO7A
proteolysis (GO:0006508)	2.73	2	TMPRSS3, HGF
positive regulation of cell proliferation (GO:0008284)	3.01	2	S1PR2, HGF
reproductive structure development (GO:0048608)	4.08	2	GJB3, GJB2
regulation of body fluid levels (GO:0050878)	3.76	2	ADCY1, ATP2B2
cellular response to nitrogen compound (GO:1901699)	3.79	2	ADCY1, CIB2
positive regulation of cellular catabolic process (GO:0031331)	4.15	2	RDX, PNPT1
barbed-end actin filament capping (GO:0051016)	7.16	2	TRIOBP, EPS8
cellular response to hormone stimulus (GO:0032870)	3.99	2	ADCY1, RDX
cell-cell junction organization (GO:0045216)	4.66	2	GJB2, MARVELD2
phenol-containing compound metabolic process (GO:0018958)	5.33	2	LRTOMT, ATP2B2
cell junction assembly (GO:0034329)	4.86	2	GJB2, MARVELD2
protein oligomerization (GO:0051259)	3.71	2	SLC26A5, PNPT1
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	SERPINB6, HGF
regulation of cellular response to oxidative stress (GO:1900407)	5.72	2	MET, HGF
cellular amide metabolic process (GO:0043603)	3.23	2	CLIC5, KARS
establishment of endothelial barrier (GO:0061028)	6.47	2	RDX, MARVELD2
cellular response to organic cyclic compound (GO:0071407)	3.93	2	ADCY1, CIB2
negative regulation of cellular response to oxidative stress (GO:1900408)	6.23	2	MET, HGF
secretion by cell (GO:0032940)	3.59	2	OTOF, HGF
auditory receptor cell differentiation (GO:0042491)	7.53	2	PCDH15, MYO7A
negative regulation of response to reactive oxygen species (GO:1901032)	6.96	2	MET, HGF
regulation of response to reactive oxygen species (GO:1901031)	6.29	2	MET, HGF
negative regulation of proteolysis (GO:0045861)	3.98	2	SERPINB6, HGF
embryo development (GO:0009790)	4.2	2	GJB3, FOXI1
activation of MAPK activity (GO:0000187)	4.79	2	S1PR2, HGF
cyclic nucleotide metabolic process (GO:0009187)	5.67	2	ADCY1, ATP2B2
regulation of cellular catabolic process (GO:0031329)	3.83	2	RDX, PNPT1
cell junction organization (GO:0034330)	4.51	2	GJB2, MARVELD2
cell cycle phase transition (GO:0044770)	4.24	2	USH1C, EPS8
mitotic cell cycle phase transition (GO:0044772)	4.27	2	USH1C, EPS8
endothelial cell development (GO:0001885)	6.23	2	RDX, MARVELD2
purine-containing compound metabolic process (GO:0072521)	4.0	2	ADCY1, ATP2B2
walking behavior (GO:0090659)	6.23	2	PCDH15, KCNJ10
regulation of cellular pH (GO:0030641)	5.41	2	SLC26A5, SLC26A4
morphogenesis of an epithelium (GO:0002009)	4.08	2	MET, PCDH15
regulation of cell death (GO:0010941)	2.43	2	MET, HGF
actin cytoskeleton reorganization (GO:0031532)	5.84	2	S1PR2, EPS8
cellular response to organonitrogen compound (GO:0071417)	3.87	2	ADCY1, CIB2
arabinose metabolic process (GO:0019566)	9.04	2	OTOGL, OTOG
nitrogen compound transport (GO:0071705)	3.54	2	PNPT1, KCNJ10
regulation of programmed cell death (GO:0043067)	2.49	2	MET, HGF
negative regulation of peptidase activity (GO:0010466)	4.22	2	SERPINB6, HGF
tissue morphogenesis (GO:0048729)	3.87	2	MET, PCDH15
negative regulation of programmed cell death (GO:0043069)	3.02	2	MET, HGF
negative regulation of autophagy (GO:0010507)	5.76	2	MET, HGF
transcription, DNA-templated (GO:0006351)	1.91	2	ESRRB, FOXI1
protein phosphorylation (GO:0006468)	2.89	2	MET, MYO3A
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	GRXCR1, HGF
regulation of endopeptidase activity (GO:0052548)	3.8	2	SERPINB6, HGF
L-arabinose metabolic process (GO:0046373)	9.04	2	OTOGL, OTOG
vesicle localization (GO:0051648)	4.85	2	OTOF, MYO7A
cell-cell signaling (GO:0007267)	3.35	2	GJB2, HGF
positive chemotaxis (GO:0050918)	6.17	2	MET, HGF
cellular response to oxidative stress (GO:0034599)	4.7	2	PNPT1, GJB2
organelle assembly (GO:0070925)	3.75	2	PCDH15, MYO7A
regulation of response to oxidative stress (GO:1902882)	5.62	2	MET, HGF
negative regulation of response to oxidative stress (GO:1902883)	6.23	2	MET, HGF
organelle localization (GO:0051640)	3.94	2	OTOF, MYO7A
single-organism cellular localization (GO:1902580)	3.16	2	OTOF, MYO7A
carbohydrate metabolic process (GO:0005975)	3.26	2	OTOGL, OTOG
cell part morphogenesis (GO:0032990)	3.99	2	ADCY1, PNPT1
regulation of cell cycle (GO:0051726)	2.93	2	RDX, PNPT1
epidermal cell differentiation (GO:0009913)	5.13	2	PCDH15, MYO7A
response to thyroid hormone (GO:0097066)	6.64	2	RDX, SLC26A5
sulfur compound transport (GO:0072348)	6.33	2	SLC26A5, SLC26A4
ribose phosphate metabolic process (GO:0019693)	4.06	2	ADCY1, ATP2B2
multicellular organism metabolic process (GO:0044236)	5.2	2	CLIC5, COL11A2
response to ketone (GO:1901654)	4.53	2	ADCY1, GJB2
regulation of multicellular organismal development (GO:2000026)	2.31	2	S1PR2, HGF
organelle fission (GO:0048285)	3.79	2	TRIOBP, HGF
regulation of peptidase activity (GO:0052547)	3.75	2	SERPINB6, HGF
protein transport (GO:0015031)	2.62	2	MYO6, MYO7A
dicarboxylic acid transport (GO:0006835)	5.62	2	SLC26A5, SLC26A4
organic hydroxy compound metabolic process (GO:1901615)	3.84	2	LRTOMT, ATP2B2
RNA processing (GO:0006396)	3.01	2	PNPT1, KARS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
actin filament bundle organization (GO:0061572)	-	5.82	0.001	ESPN, CDH23, EPS8, MYO3A, MYO7A, USH1C
detection of external stimulus (GO:0009581)	-	4.98	0.016	LHFPL5, STRC, TMC1, PCDH15, ATP2B2, LOXHD1
cell projection organization (GO:0030030)	-	3.14	0.0	ADCY1, LHFPL5, DFNB31, MYO6, RDX, PCDH15, CLIC5, STRC, ATP2B2, DCDC2, MYO7A, TBC1D24, GRXCR1
behavior (GO:0007610)	-	3.47	0.0	ADCY1, MYO15A, KCNJ10, MYO6, MET, ESPN, CDH23, MYO3A, RDX, PCDH15, DCDC2, EPS8, DFNB31, ATP2B2, GJB2, USH1C, OTOG
auditory receptor cell stereocilium organization (GO:0060088)	-	7.24	0.0	LHFPL5, STRC, PCDH15, CLIC5, ATP2B2, MYO7A, USH1C
inner ear receptor cell development (GO:0060119)	-	6.96	0.006	TMC1, GRXCR1, LRTOMT
response to mechanical stimulus (GO:0009612)	-	4.41	0.017	LHFPL5, STRC, TMC1, PCDH15, ATP2B2, LOXHD1
inner ear receptor cell differentiation (GO:0060113)	-	7.02	0.013	MYO6, USH1C, MYO7A, DFNB31, GRXCR1
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.007	ADCY1, MYO15A, HGF, MYO6, TMIE, MET, USH1C, GJB6, PCDH15, PNPT1, DCDC2, GRXCR1, MYO7A, ESRRB, FOXI1
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.049	LHFPL5, STRC, DFNB31, COL11A2, MET, DCDC2, MARVELD2, MYO6, RDX, USH1C, EPS8, TRIOBP, CLIC5, TBC1D24, GRXCR1, HGF, ESPN, CLDN14, ATP2B2, GJB2, ESRRB, ADCY1, OTOF, KCNJ10, PCDH15, PNPT1, MYO7A
hair cell differentiation (GO:0035315)	-	7.02	0.0	MYO6, USH1C, MYO7A, DFNB31, GRXCR1
detection of mechanical stimulus (GO:0050982)	-	5.94	0.0	LHFPL5, DFNB31, TMC1, CDH23, PCDH15, STRC, ATP2B2, LOXHD1
detection of mechanical stimulus involved in sensory perception (GO:0050974)	-	6.43	0.0	LHFPL5, STRC, TMC1, CDH23, PCDH15, ATP2B2
arabinose metabolic process (GO:0019566)	-	9.04	0.01	OTOGL, OTOG
cellular component organization (GO:0016043)	-	1.24	0.042	LHFPL5, STRC, DFNB31, COL11A2, MET, DCDC2, MARVELD2, MYO6, RDX, USH1C, EPS8, TRIOBP, CLIC5, TBC1D24, GRXCR1, HGF, ESPN, CLDN14, ATP2B2, GJB2, ESRRB, ADCY1, OTOF, KCNJ10, PCDH15, PNPT1, MYO7A
single-organism process (GO:0044699)	-	0.48	0.001	MARVELD2, LHFPL5, STRC, DFNB31, COL11A2, MET, CDH23, OTOA, LRTOMT, ELMOD3, DCDC2, MSRB3, GJB3, LOXHD1, TMIE, MYO6, RDX, ESRRB, TMC1, TRIOBP, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, TMPRSS3, SYNE4, TBC1D24, OTOGL, GRXCR1, MYO15A, HGF, ESPN, SLC26A4, MYO3A, CLDN14, CIB2, ATP2B2, TPRN, GJB2, USH1C, OTOG, OTOF, ADCY1, FAM65B, KCNJ10, KARS, GJB6, PCDH15, PNPT1, FOXI1, MYO7A, TSPEAR
sensory perception of mechanical stimulus (GO:0050954)	-	4.79	0.0	DFNB31, COL11A2, CDH23, LRTOMT, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, GRXCR1, MYO15A, ESPN, MYO3A, PCDH15, ATP2B2, GJB2, USH1C, OTOA, OTOF, SLC26A4, GJB6, TPRN, OTOG, TSPEAR
system process (GO:0003008)	-	2.3	0.0	LHFPL5, DFNB31, COL11A2, CDH23, LRTOMT, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, TMC1, STRC, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, TPRN, MYO15A, ESPN, MYO3A, PCDH15, ATP2B2, GJB2, USH1C, OTOF, ADCY1, OTOA, SLC26A4, KCNJ10, GJB6, GRXCR1, OTOG, TSPEAR
locomotory behavior (GO:0007626)	-	4.53	0.003	MYO15A, KCNJ10, MYO6, ESPN, CDH23, MYO3A, PCDH15, EPS8, DFNB31, ATP2B2, OTOG, USH1C
detection of abiotic stimulus (GO:0009582)	-	4.96	0.018	LHFPL5, STRC, TMC1, PCDH15, ATP2B2, LOXHD1
multicellular organismal process (GO:0032501)	-	1.45	0.0	LHFPL5, STRC, DFNB31, COL11A2, MET, CDH23, LRTOMT, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, USH1C, TMC1, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, TPRN, MYO15A, HGF, ESPN, MYO3A, PCDH15, CIB2, ATP2B2, GJB2, ESRRB, OTOF, ADCY1, OTOA, SLC26A4, KCNJ10, GJB6, GRXCR1, OTOG, TSPEAR
sensory perception of sound (GO:0007605)	-	4.82	0.0	DFNB31, COL11A2, CDH23, LRTOMT, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, GRXCR1, MYO15A, ESPN, MYO3A, PCDH15, ATP2B2, GJB2, USH1C, OTOA, OTOF, SLC26A4, GJB6, TPRN, OTOG, TSPEAR
neurological system process (GO:0050877)	-	2.64	0.0	LHFPL5, STRC, DFNB31, COL11A2, MET, CDH23, LRTOMT, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, RDX, TMC1, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, TPRN, MYO15A, HGF, ESPN, MYO3A, PCDH15, ATP2B2, GJB2, USH1C, OTOF, ADCY1, OTOA, SLC26A4, KCNJ10, GJB6, GRXCR1, OTOG, TSPEAR
equilibrioception (GO:0050957)	-	7.94	0.0	CDH23, PCDH15, USH1C, MYO7A
actin filament bundle assembly (GO:0051017)	-	5.88	0.001	ESPN, CDH23, EPS8, MYO3A, MYO7A, USH1C
sensory perception (GO:0007600)	-	2.93	0.0	DFNB31, COL11A2, MET, CDH23, LRTOMT, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, RDX, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, GRXCR1, MYO15A, HGF, ESPN, MYO3A, PCDH15, ATP2B2, GJB2, USH1C, OTOF, OTOA, SLC26A4, KCNJ10, GJB6, TPRN, OTOG, TSPEAR
sensory perception of light stimulus (GO:0050953)	-	4.4	0.038	KCNJ10, MYO6, USH1C, ESPN, CDH23, MYO3A, PCDH15, DFNB31, MYO7A, ESRRB, GJB2
L-arabinose metabolic process (GO:0046373)	-	9.04	0.01	OTOGL, OTOG
visual perception (GO:0007601)	-	4.41	0.035	KCNJ10, MYO6, USH1C, ESPN, CDH23, MYO3A, PCDH15, DFNB31, MYO7A, ESRRB, GJB2
detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	-	7.09	0.0	PCDH15, LHFPL5, TMC1, ATP2B2, STRC
parallel actin filament bundle assembly (GO:0030046)	NEW	8.34	0.01	ESPN, USH1C, MYO7A
inner ear morphogenesis (GO:0042472)	-	5.62	0.0	TMIE, MYO7A, MYO6, MYO15A, EPS8, DFNB31, USH1C, FOXI1
single-multicellular organism process (GO:0044707)	-	1.78	0.0	LHFPL5, STRC, DFNB31, COL11A2, MET, CDH23, LRTOMT, DCDC2, MARVELD2, GJB3, LOXHD1, TMIE, MYO6, USH1C, TMC1, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, TPRN, MYO15A, HGF, ESPN, MYO3A, PCDH15, CIB2, ATP2B2, GJB2, ESRRB, OTOF, ADCY1, OTOA, SLC26A4, KCNJ10, GJB6, GRXCR1, OTOG, TSPEAR
inner ear receptor stereocilium organization (GO:0060122)	-	6.47	0.0	LHFPL5, DFNB31, PCDH15, CLIC5, STRC, ATP2B2, MYO7A, USH1C, GRXCR1
auditory receptor cell differentiation (GO:0042491)	-	7.53	0.017	USH1C, GRXCR1, MYO6
mechanoreceptor differentiation (GO:0042490)	-	6.78	0.037	MYO6, USH1C, MYO7A, DFNB31, GRXCR1
photoreceptor cell maintenance (GO:0045494)	-	6.17	0.003	MYO7A, CDH23, CIB2, PCDH15, DFNB31, USH1C
negative regulation of hydrogen peroxide-mediated programmed cell death (GO:1901299)	-	7.94	0.015	MET, HGF

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	56	CABP2, LHFPL5, STRC, MARVELD2, COL11A2, MET, CDH23, GRXCR2, LRTOMT, PTPRQ, DCDC2, MSRB3, GJB3, LOXHD1, S1PR2, MYO6, RDX, ESRRB, TMC1, SERPINB6, ELMOD3, EPS8, SLC26A5, DFNB59, CLIC5, TECTA, MYO7A, TMPRSS3, SYNE4, TBC1D24, TPRN, MYO15A, HGF, ESPN, ILDR1, SLC26A4, MYO3A, CLDN14, CIB2, ATP2B2, TRIOBP, GJB2, USH1C, OTOF, ADCY1, FAM65B, OTOA, KARS, KCNJ10, GRXCR1, GJB6, PCDH15, PNPT1, FOXI1, OTOG, TSPEAR
membrane (GO:0016020)	0.68	39	CABP2, LHFPL5, MYO7A, MET, CDH23, OTOA, LRTOMT, PTPRQ, MARVELD2, GJB3, LOXHD1, S1PR2, TMIE, MYO6, RDX, TMC1, EPS8, SLC26A5, CLIC5, TECTA, TMPRSS3, SYNE4, HGF, ILDR1, SLC26A4, CIB2, CLDN14, ATP2B2, GJB2, USH1C, OTOF, ADCY1, FAM65B, KARS, KCNJ10, GJB6, PCDH15, PNPT1, OTOG
intracellular part (GO:0044424)	0.28	38	CABP2, MARVELD2, COL11A2, LRTOMT, DCDC2, MSRB3, GJB3, MYO6, RDX, USH1C, SERPINB6, ELMOD3, EPS8, SLC26A5, TRIOBP, CLIC5, TMPRSS3, SYNE4, TBC1D24, MYO15A, HGF, ESPN, ILDR1, MYO3A, CLDN14, CIB2, ATP2B2, GJB2, ESRRB, ADCY1, FAM65B, OTOF, KARS, GJB6, PCDH15, PNPT1, MYO7A, FOXI1
organelle (GO:0043226)	0.4	35	CABP2, STRC, MSRB3, COL11A2, CIB2, DCDC2, MARVELD2, MYO6, RDX, USH1C, TRIOBP, EPS8, ELMOD3, CLIC5, TECTA, TMPRSS3, SYNE4, GRXCR1, MYO15A, ESPN, SERPINB6, CLDN14, MYO3A, ATP2B2, GJB2, ESRRB, OTOF, ADCY1, FAM65B, KARS, SLC26A4, PCDH15, PNPT1, MYO7A, FOXI1
membrane part (GO:0044425)	0.95	32	LHFPL5, MYO7A, MET, CDH23, LRTOMT, PTPRQ, MARVELD2, GJB3, S1PR2, TMIE, MYO6, RDX, TMC1, EPS8, SLC26A5, CLIC5, TECTA, TMPRSS3, SYNE4, ILDR1, OTOA, CLDN14, ATP2B2, GJB2, OTOF, ADCY1, FAM65B, KCNJ10, SLC26A4, GJB6, PCDH15, OTOG
organelle part (GO:0044422)	0.79	32	LHFPL5, MYO7A, COL11A2, CDH23, GRXCR2, DCDC2, STRC, MYO6, RDX, USH1C, TMC1, TRIOBP, EPS8, ELMOD3, CLIC5, TMPRSS3, SYNE4, GRXCR1, MYO15A, HGF, ESPN, MYO3A, PCDH15, CIB2, LOXHD1, ESRRB, FAM65B, OTOF, KARS, PNPT1, TPRN, TSPEAR
cytoplasm (GO:0005737)	1.01	30	CABP2, MYO7A, LRTOMT, DCDC2, MARVELD2, GJB3, MYO6, RDX, TRIOBP, EPS8, SLC26A5, ELMOD3, CLIC5, SYNE4, TBC1D24, MYO15A, ESPN, ILDR1, SERPINB6, PCDH15, CIB2, ATP2B2, GJB2, USH1C, ADCY1, FAM65B, OTOF, KARS, PNPT1, MYO3A
neuron part (GO:0097458)	2.64	28	LHFPL5, MYO7A, CDH23, GRXCR2, PTPRQ, DCDC2, STRC, OTOF, RDX, TMC1, DFNB59, EPS8, ELMOD3, CLIC5, TMPRSS3, TBC1D24, GRXCR1, MYO15A, ESPN, CIB2, PCDH15, ATP2B2, LOXHD1, USH1C, FAM65B, KCNJ10, TPRN, TSPEAR
intracellular organelle (GO:0043229)	0.51	28	CABP2, MYO7A, COL11A2, DCDC2, MSRB3, MYO6, RDX, USH1C, TRIOBP, EPS8, ELMOD3, CLIC5, TMPRSS3, SYNE4, MYO15A, ESPN, SERPINB6, CLDN14, MYO3A, ATP2B2, GJB2, ESRRB, ADCY1, FAM65B, OTOF, KARS, PNPT1, FOXI1
plasma membrane (GO:0005886)	1.39	28	CABP2, LHFPL5, MET, CDH23, OTOA, MARVELD2, GJB3, S1PR2, MYO6, RDX, EPS8, SLC26A5, TECTA, ILDR1, SLC26A4, CIB2, CLDN14, ATP2B2, GJB2, USH1C, OTOF, ADCY1, FAM65B, KCNJ10, KARS, GJB6, PCDH15, OTOG
membrane-bounded organelle (GO:0043227)	0.47	27	CABP2, MSRB3, DCDC2, MARVELD2, MYO6, RDX, EPS8, TRIOBP, CLIC5, TECTA, TMPRSS3, SYNE4, MYO15A, SERPINB6, CLDN14, ATP2B2, GJB2, ESRRB, OTOF, ADCY1, FAM65B, KARS, SLC26A4, PCDH15, PNPT1, MYO7A, FOXI1
intrinsic component of membrane (GO:0031224)	1.13	26	LHFPL5, MET, CDH23, LRTOMT, PTPRQ, MARVELD2, GJB3, S1PR2, TMIE, OTOF, TMC1, SLC26A5, CLIC5, TECTA, TMPRSS3, SYNE4, ILDR1, CLDN14, ATP2B2, GJB2, ADCY1, OTOA, KCNJ10, SLC26A4, GJB6, PCDH15
integral component of membrane (GO:0016021)	1.14	24	LHFPL5, MET, CDH23, LRTOMT, PTPRQ, MARVELD2, GJB3, S1PR2, TMIE, OTOF, TMC1, SLC26A5, CLIC5, TMPRSS3, SYNE4, ILDR1, CLDN14, ATP2B2, GJB2, ADCY1, KCNJ10, SLC26A4, GJB6, PCDH15
cytoplasmic part (GO:0044444)	0.82	22	CABP2, MSRB3, COL11A2, MARVELD2, MYO6, RDX, EPS8, CLIC5, TMPRSS3, HGF, ILDR1, SERPINB6, CLDN14, ATP2B2, GJB2, USH1C, FAM65B, OTOF, KARS, GJB6, PNPT1, MYO7A
cell projection (GO:0042995)	2.47	22	GRXCR2, MYO7A, CDH23, DCDC2, STRC, MYO6, RDX, EPS8, ELMOD3, CLIC5, GRXCR1, MYO15A, ESPN, CIB2, PCDH15, MYO3A, ATP2B2, LOXHD1, USH1C, FAM65B, TPRN, TSPEAR
plasma membrane part (GO:0044459)	1.95	20	ADCY1, OTOA, MYO6, KCNJ10, FAM65B, RDX, TMC1, SLC26A4, EPS8, SLC26A5, GJB6, GJB2, MET, MARVELD2, LHFPL5, ATP2B2, GJB3, MYO7A, OTOG, OTOF
actin-based cell projection (GO:0098858)	4.83	20	FAM65B, MYO15A, MYO7A, MYO6, GRXCR1, RDX, ESPN, EPS8, CDH23, GRXCR2, MYO3A, PCDH15, ELMOD3, TSPEAR, CLIC5, CIB2, STRC, LOXHD1, USH1C, TPRN
intracellular membrane-bounded organelle (GO:0043231)	0.6	20	CABP2, ADCY1, FAM65B, MYO7A, KARS, MYO6, PNPT1, MSRB3, CLDN14, TRIOBP, CLIC5, SERPINB6, ATP2B2, TMPRSS3, DCDC2, GJB2, ESRRB, SYNE4, FOXI1, OTOF
intracellular organelle part (GO:0044446)	0.81	17	MYO15A, KARS, COL11A2, RDX, ESPN, MYO6, TRIOBP, MYO3A, HGF, PNPT1, CLIC5, MYO7A, TMPRSS3, DCDC2, SYNE4, ESRRB, OTOF
stereocilium (GO:0032420)	6.4	17	GRXCR2, MYO15A, MYO7A, RDX, ESPN, EPS8, CDH23, TSPEAR, CIB2, PCDH15, ELMOD3, CLIC5, GRXCR1, STRC, LOXHD1, USH1C, TPRN
plasma membrane region (GO:0098590)	2.97	16	MARVELD2, FAM65B, SLC26A4, MYO6, KCNJ10, RDX, GJB6, OTOA, EPS8, SLC26A5, MET, ATP2B2, LHFPL5, OTOG, MYO7A, OTOF
extracellular region part (GO:0044421)	1.57	16	ADCY1, OTOA, MYO15A, MYO6, COL11A2, RDX, SERPINB6, SLC26A4, CIB2, HGF, PCDH15, CLIC5, EPS8, TECTA, ATP2B2, OTOG
protein complex (GO:0043234)	1.51	15	MYO15A, KARS, COL11A2, ESPN, MYO6, SERPINB6, MYO3A, SYNE4, GJB6, PNPT1, CLIC5, EPS8, MYO7A, GJB3, GJB2
macromolecular complex (GO:0032991)	1.35	15	MYO15A, KARS, COL11A2, GJB3, ESPN, MYO6, SERPINB6, MYO3A, GJB6, PNPT1, CLIC5, EPS8, MYO7A, SYNE4, GJB2
non-membrane-bounded organelle (GO:0043228)	1.76	14	MYO15A, KARS, COL11A2, FAM65B, RDX, ESPN, ELMOD3, MYO3A, TRIOBP, CLIC5, EPS8, MYO7A, DCDC2, USH1C
vesicle (GO:0031982)	1.64	14	ADCY1, MYO15A, MARVELD2, MYO6, OTOF, RDX, SLC26A4, EPS8, PCDH15, CLIC5, SERPINB6, TECTA, ATP2B2, MYO7A
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	14	FAM65B, MYO15A, KARS, COL11A2, RDX, ESPN, ELMOD3, MYO3A, TRIOBP, CLIC5, EPS8, MYO7A, DCDC2, USH1C
cytoskeleton (GO:0005856)	2.55	12	MYO15A, FAM65B, KARS, RDX, ESPN, ELMOD3, MYO3A, TRIOBP, CLIC5, MYO7A, DCDC2, USH1C
cell junction (GO:0030054)	2.75	12	ATP2B2, OTOF, RDX, GJB6, ILDR1, CLDN14, CIB2, TRIOBP, EPS8, MARVELD2, GJB2, GJB3
membrane-bounded vesicle (GO:0031988)	1.71	12	ADCY1, MYO15A, MYO6, SLC26A4, RDX, EPS8, PCDH15, CLIC5, SERPINB6, TECTA, ATP2B2, MYO7A
cell projection part (GO:0044463)	2.97	11	FAM65B, MYO6, SLC26A4, TMC1, LHFPL5, EPS8, DCDC2, STRC, MYO7A, TBC1D24, ESPN
extracellular organelle (GO:0043230)	1.89	11	ADCY1, MYO15A, MYO6, SLC26A4, RDX, EPS8, PCDH15, CLIC5, SERPINB6, TECTA, ATP2B2
extracellular exosome (GO:0070062)	1.89	11	ADCY1, MYO15A, MYO6, SLC26A4, RDX, EPS8, PCDH15, CLIC5, SERPINB6, TECTA, ATP2B2
extracellular vesicle (GO:1903561)	1.89	11	ADCY1, MYO15A, MYO6, SLC26A4, RDX, EPS8, PCDH15, CLIC5, SERPINB6, TECTA, ATP2B2
apical plasma membrane (GO:0016324)	4.13	10	FAM65B, MARVELD2, SLC26A4, RDX, GJB6, OTOA, ATP2B2, LHFPL5, OTOG, MYO7A
nucleus (GO:0005634)	1.07	10	ADCY1, KARS, MYO6, SERPINB6, TRIOBP, CLIC5, DCDC2, SYNE4, ESRRB, FOXI1
cytoskeletal part (GO:0044430)	2.49	10	MYO15A, MYO6, RDX, ESPN, MYO3A, TRIOBP, CLIC5, MYO7A, DCDC2, SYNE4
extracellular region (GO:0005576)	2.18	10	OTOA, KARS, COL11A2, MET, OTOGL, HGF, PCDH15, TECTA, OTOG, TSPEAR
cytosol (GO:0005829)	1.68	9	KARS, MYO6, GJB6, ILDR1, SERPINB6, MSRB3, MYO7A, USH1C, OTOF
cilium (GO:0005929)	3.89	9	ATP2B2, ELMOD3, CIB2, PCDH15, DCDC2, STRC, MYO7A, USH1C, GRXCR1
primary cilium (GO:0072372)	4.64	8	MYO7A, ELMOD3, CIB2, PCDH15, DCDC2, STRC, USH1C, GRXCR1
cluster of actin-based cell projections (GO:0098862)	5.54	8	LHFPL5, MYO15A, ESPN, PTPRQ, EPS8, PCDH15, CLIC5, USH1C
synapse (GO:0045202)	3.58	8	MYO7A, OTOF, TBC1D24, EPS8, PCDH15, CIB2, ATP2B2, USH1C
nonmotile primary cilium (GO:0031513)	5.14	8	MYO7A, ELMOD3, CIB2, PCDH15, DCDC2, STRC, USH1C, GRXCR1
microvillus (GO:0005902)	5.69	7	GRXCR2, MYO6, RDX, ESPN, MYO7A, USH1C, GRXCR1
stereocilium bundle (GO:0032421)	7.5	6	LHFPL5, MYO15A, ESPN, PTPRQ, PCDH15, CLIC5
intrinsic component of plasma membrane (GO:0031226)	2.53	6	ADCY1, KCNJ10, SLC26A4, MET, SLC26A5, ATP2B2
integral component of plasma membrane (GO:0005887)	2.57	6	ADCY1, KCNJ10, SLC26A4, MET, SLC26A5, ATP2B2
cell-cell junction (GO:0005911)	3.85	6	GJB6, ILDR1, CLDN14, MARVELD2, GJB2, GJB3
membrane protein complex (GO:0098796)	2.84	5	GJB6, GJB2, CLIC5, GJB3, EPS8
endoplasmic reticulum (GO:0005783)	2.56	5	TMPRSS3, MSRB3, CLDN14, ATP2B2, OTOF
extracellular space (GO:0005615)	2.63	5	RDX, OTOG, SERPINB6, PCDH15, HGF
mitochondrion (GO:0005739)	2.42	4	MSRB3, PNPT1, FAM65B, KARS
apical part of cell (GO:0045177)	5.34	4	RDX, USH1C, MYO6, OTOF
cytoplasmic region (GO:0099568)	4.51	4	EPS8, CLIC5, MYO6, MYO7A
organelle membrane (GO:0031090)	1.97	4	SYNE4, MYO6, MYO7A, OTOF
whole membrane (GO:0098805)	2.85	4	SYNE4, MYO6, MYO7A, OTOF
stereocilium tip (GO:0032426)	7.61	4	ESPN, LHFPL5, TMC1, STRC
cytoplasmic vesicle (GO:0031410)	2.87	4	MARVELD2, MYO6, MYO7A, OTOF
bounding membrane of organelle (GO:0098588)	2.39	4	SYNE4, MYO6, MYO7A, OTOF
organelle lumen (GO:0043233)	3.05	4	PNPT1, COL11A2, KARS, HGF
cell projection membrane (GO:0031253)	4.11	4	FAM65B, MYO6, EPS8, SLC26A4
membrane-enclosed lumen (GO:0031974)	3.05	4	PNPT1, COL11A2, KARS, HGF
basolateral plasma membrane (GO:0016323)	4.56	4	SLC26A5, MARVELD2, OTOF, KCNJ10
plasma membrane protein complex (GO:0098797)	3.55	4	GJB6, GJB3, GJB2, EPS8
intracellular organelle lumen (GO:0070013)	3.05	4	PNPT1, COL11A2, KARS, HGF
myosin complex (GO:0016459)	5.55	4	MYO15A, MYO6, MYO7A, MYO3A
intracellular vesicle (GO:0097708)	2.86	4	MARVELD2, MYO6, MYO7A, OTOF
synapse part (GO:0044456)	3.42	4	EPS8, TBC1D24, OTOF, KCNJ10
cell surface (GO:0009986)	3.44	4	MET, OTOA, TSPEAR, STRC
photoreceptor outer segment (GO:0001750)	5.78	4	PCDH15, USH1C, MYO7A, CIB2
kinocilium (GO:0060091)	8.01	4	ELMOD3, DCDC2, GRXCR1, STRC
cell cortex (GO:0005938)	4.78	4	EPS8, CLIC5, MYO6, MYO7A
actin cytoskeleton (GO:0015629)	4.39	3	TRIOBP, CLIC5, ESPN
extracellular matrix (GO:0031012)	3.81	3	OTOA, COL11A2, TECTA
filopodium (GO:0030175)	5.48	3	RDX, FAM65B, MYO3A
brush border (GO:0005903)	5.68	3	ESPN, USH1C, EPS8
cell-substrate adherens junction (GO:0005924)	3.83	3	RDX, TRIOBP, CIB2
connexon complex (GO:0005922)	6.71	3	GJB6, GJB3, GJB2
cell-substrate junction (GO:0030055)	3.82	3	RDX, TRIOBP, CIB2
microtubule organizing center (GO:0005815)	3.42	3	SYNE4, CLIC5, TRIOBP
cytoplasmic vesicle part (GO:0044433)	3.41	3	MYO6, HGF, OTOF
endoplasmic reticulum part (GO:0044432)	2.73	3	TMPRSS3, COL11A2, OTOF
photoreceptor inner segment (GO:0001917)	6.25	3	USH1C, MYO7A, CIB2
gap junction (GO:0005921)	6.34	3	GJB6, GJB3, GJB2
neuronal cell body (GO:0043025)	3.9	3	TMPRSS3, DFNB59, ATP2B2
Golgi apparatus (GO:0005794)	2.7	3	CABP2, CLIC5, MYO6
filamentous actin (GO:0031941)	6.76	3	ESPN, MYO6, MYO3A
occluding junction (GO:0070160)	5.07	3	CLDN14, ILDR1, MARVELD2
anchoring junction (GO:0070161)	3.61	3	RDX, TRIOBP, CIB2
cell body (GO:0044297)	3.74	3	TMPRSS3, DFNB59, ATP2B2
adherens junction (GO:0005912)	3.66	3	RDX, TRIOBP, CIB2
presynapse (GO:0098793)	4.97	3	TBC1D24, OTOF, KCNJ10
nuclear part (GO:0044428)	1.55	3	SYNE4, ESRRB, MYO6
proteinaceous extracellular matrix (GO:0005578)	4.01	3	OTOA, COL11A2, TECTA
tricellular tight junction (GO:0061689)	8.42	2	ILDR1, MARVELD2
endoplasmic reticulum membrane (GO:0005789)	2.95	2	TMPRSS3, OTOF
neuromuscular junction (GO:0031594)	5.81	2	TBC1D24, CIB2
ion channel complex (GO:0034702)	4.18	2	CLIC5, EPS8
lateral plasma membrane (GO:0016328)	5.89	2	SLC26A5, GJB2
focal adhesion (GO:0005925)	3.83	2	RDX, TRIOBP
bicellular tight junction (GO:0005923)	5.09	2	CLDN14, MARVELD2
anchored component of membrane (GO:0031225)	4.77	2	OTOA, TECTA
ruffle (GO:0001726)	5.28	2	RDX, MYO6
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	MYO6, MYO7A
vacuolar membrane (GO:0005774)	3.45	2	MYO6, MYO7A
nucleoplasm (GO:0005654)	1.89	2	ESRRB, MYO6
vacuolar part (GO:0044437)	3.26	2	MYO6, MYO7A
leading edge membrane (GO:0031256)	4.9	2	EPS8, MYO6
perinuclear region of cytoplasm (GO:0048471)	3.35	2	CABP2, MYO6
transmembrane transporter complex (GO:1902495)	4.06	2	CLIC5, EPS8
nuclear membrane (GO:0031965)	4.2	2	SYNE4, MYO6
membrane region (GO:0098589)	3.95	2	ADCY1, MYO6
transporter complex (GO:1990351)	4.04	2	CLIC5, EPS8
cytoplasmic vesicle membrane (GO:0030659)	3.67	2	OTOF, MYO6
vesicle membrane (GO:0012506)	3.63	2	OTOF, MYO6
ruffle membrane (GO:0032587)	5.42	2	EPS8, MYO6
intracellular (GO:0005622)	2.37	2	ADCY1, DCDC2
lysosomal membrane (GO:0005765)	4.19	2	MYO6, MYO7A
unconventional myosin complex (GO:0016461)	7.72	2	MYO6, MYO7A
mitochondrial part (GO:0044429)	2.92	2	PNPT1, KARS
lytic vacuole membrane (GO:0098852)	4.19	2	MYO6, MYO7A

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
plasma membrane region (GO:0098590)	-	2.97	0.0	S1PR2, OTOA, MARVELD2, ATP2B2, KCNJ10, HGF, MET, GJB6, MYO6, SLC26A4, MYO3A, SLC26A5, RDX, LHFPL5, DFNB31, MYO7A, OTOG, USH1C, TSPEAR, OTOF
filamentous actin (GO:0031941)	-	6.76	0.016	ESPN, MYO6, MYO3A
primary cilium (GO:0072372)	-	4.64	0.0	MYO7A, PCDH15, ELMOD3, STRC, USH1C, GRXCR1
stereocilium bundle tip (GO:0032426)	-	7.61	0.0	ESPN, LHFPL5, TMC1, MYO3A, STRC
apical plasma membrane (GO:0016324)	-	4.13	0.0	S1PR2, OTOA, MARVELD2, SLC26A4, KCNJ10, RDX, GJB6, MYO6, LHFPL5, MYO3A, SLC26A5, MET, ATP2B2, MYO7A, OTOG, DFNB31
plasma membrane part (GO:0044459)	-	1.95	0.004	MARVELD2, OTOA, OTOG, OTOF, KCNJ10, RDX, TMC1, MYO6, SLC26A4, EPS8, SLC26A5, GJB6, MET, ATP2B2, LHFPL5, GJB3, GJB2, TSPEAR, MYO7A
membrane region (GO:0098589)	-	3.95	0.003	LHFPL5, DFNB31, MET, MARVELD2, S1PR2, MYO6, RDX, EPS8, SLC26A5, TMPRSS3, MYO7A, HGF, ESPN, MYO3A, PCDH15, ATP2B2, GJB2, USH1C, OTOF, OTOA, SLC26A4, KCNJ10, GJB6, OTOG, TSPEAR
unconventional myosin complex (GO:0016461)	-	7.72	0.044	MYO6, MYO7A
nonmotile primary cilium (GO:0031513)	-	5.14	0.018	MYO7A, PCDH15, ELMOD3, STRC, USH1C, GRXCR1
neuron part (GO:0097458)	-	2.64	0.016	ATP2B2, MYO6, PCDH15, CIB2, DFNB59, MYO3A, EPS8, DFNB31, TMPRSS3, MYO7A, USH1C
microvillus (GO:0005902)	-	5.69	0.0	MYO15A, STRC, HGF, KCNJ10, RDX, ESPN, MYO6, CDH23, PCDH15, EPS8, ELMOD3, CLIC5, TSPEAR, DFNB31, TPRN, LOXHD1, USH1C, GRXCR1, MYO7A
myosin complex (GO:0016459)	-	5.55	0.004	MYO15A, MYO6, MYO3A, DFNB31, MYO7A
photoreceptor inner segment (GO:0001917)	-	6.25	0.014	MYO7A, USH1C, MYO3A, CIB2
kinocilium (GO:0060091)	-	8.01	0.0	ELMOD3, GRXCR1, STRC
stereocilium (GO:0032420)	-	6.4	0.0	MYO15A, STRC, MYO7A, RDX, ESPN, CDH23, TSPEAR, EPS8, PCDH15, ELMOD3, CLIC5, TPRN, DFNB31, LOXHD1, USH1C, GRXCR1
cilium (GO:0005929)	-	3.89	0.049	STRC, CDH23, PCDH15, MYO3A, ELMOD3, DFNB31, ATP2B2, MYO7A, USH1C, GRXCR1
basolateral plasma membrane (GO:0016323)	-	4.56	0.029	KCNJ10, MYO6, MET, MYO3A, SLC26A5, MARVELD2, ATP2B2, OTOF
cell projection (GO:0042995)	-	2.47	0.0	DFNB31, MET, CDH23, STRC, MYO6, RDX, EPS8, ELMOD3, CLIC5, GRXCR1, MYO15A, HGF, ESPN, MYO3A, PCDH15, ATP2B2, LOXHD1, USH1C, FAM65B, KARS, KCNJ10, TPRN, MYO7A, TSPEAR
connexon complex (GO:0005922)	-	6.71	0.007	GJB6, GJB3, GJB2
photoreceptor outer segment (GO:0001750)	-	5.78	0.034	PCDH15, USH1C, MYO7A
cell junction (GO:0030054)	-	2.75	0.038	S1PR2, MYO7A, OTOF, KCNJ10, RDX, GJB6, EPS8, CLDN14, MYO3A, MYO6, HGF, MET, PCDH15, CIB2, MARVELD2, TRIOBP, DFNB31, GJB3, GJB2, PTPRQ