Disease table of CHARCOT-MARIE-TOOTH DISEASE OMIM ID: PS118220

Gene-disease associations table

Gene	Associated with CHARCOT-MARIE-TOOTH DISEASE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
MORC2	ClinVar, OMIM	HGNC link	22q12.2	1	PS118220
KARS	ClinVar, OMIM, HUMSAVAR	HGNC link	16q23.1	2	PS118220, PS220290
LITAF	ClinVar, OMIM, HUMSAVAR	HGNC link	16p13.13	1	PS118220
MED25	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.33	2	PS118220, 616449
DHTKD1	ClinVar, OMIM	HGNC link	10p14	2	PS118220, 204750
JPH1	OMIM	HGNC link	8q21.11	1	PS118220
AIFM1	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq26.1	4	PS609060, PS304500, PS609129, PS118220
DNM2	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.2	4	PS118220, PS253310, PS160150, 310400
NDRG1	ClinVar, OMIM	HGNC link	8q24.22	1	PS118220
HARS	ClinVar, OMIM, HUMSAVAR	HGNC link	5q31.3	2	PS118220, PS276900
GDAP1	ClinVar, OMIM, HUMSAVAR	HGNC link	8q21.11	1	PS118220
PRPS1	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq22.3	4	PS118220, PS304500, 300661, PS309510
EGR2	ClinVar, OMIM, HUMSAVAR	HGNC link	10q21.3	1	PS118220
NEFL	ClinVar, OMIM, HUMSAVAR	HGNC link	8p21.2	1	PS118220
NEFH	ClinVar, OMIM	HGNC link	22q12.2	2	PS118220, PS105400
FIG4	ClinVar, OMIM, HUMSAVAR	HGNC link	6q21	4	PS118220, PS105400, 216340, 612691
YARS	ClinVar, OMIM, HUMSAVAR	HGNC link	1p35.1	1	PS118220
SURF1	ClinVar, OMIM	HGNC link	9q34.2	3	PS118220, PS601462, 256000
TRPV4	ClinVar, OMIM, HUMSAVAR	HGNC link	12q24.11	10	600175, PS118220, 184095, 184252, 606835, 156530, 181405, 613508, 113500, 168400
MTMR2	ClinVar, OMIM, HUMSAVAR	HGNC link	11q21	1	PS118220
FGD4	ClinVar, OMIM, HUMSAVAR	HGNC link	12p11.21	1	PS118220
RAB7A	ClinVar, OMIM, HUMSAVAR	HGNC link	3q21.3	1	PS118220
LRSAM1	ClinVar, OMIM	HGNC link	9q33.3	1	PS118220
HSPB1	ClinVar, OMIM, HUMSAVAR	HGNC link	7q11.23	2	PS118220, 608634
NAGLU	ClinVar, OMIM, HUMSAVAR	HGNC link	17q21.2	2	PS118220, PS607014
HK1	ClinVar, OMIM	HGNC link	10q22.1	2	PS118220, 235700
HSPB8	ClinVar, OMIM, HUMSAVAR	HGNC link	12q24.23	2	PS118220, 158590
VCP	ClinVar, OMIM	HGNC link	9p13.3	3	PS118220, PS105400, PS167320
IGHMBP2	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.3	3	253300, 604320, PS118220
DYNC1H1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q32.31	3	PS118220, PS158600, PS156200
LMNA	ClinVar, OMIM, HUMSAVAR	HGNC link	1q22	12	212112, PS310300, PS248370, PS176670, PS118220, PS604772, PS159000, PS115200, 613205, 275210, 610140, PS151660
COX6A1	OMIM	HGNC link	12q24.31	1	PS118220
GARS	ClinVar, OMIM, HUMSAVAR	HGNC link	7p14.3	2	PS118220, 600794
MFN2	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.22	1	PS118220
SBF1	ClinVar, OMIM, HUMSAVAR	HGNC link	22q13.33	1	PS118220
PMP22	ClinVar, OMIM, HUMSAVAR	HGNC link	17p12	4	139393, PS118220, 162500, 180800
SPG11	ClinVar, OMIM	HGNC link	15q21.1	3	PS118220, PS303350, PS105400
KIF1B	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.22	3	PS118220, 256700, 171300
PLEKHG5	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.31	2	PS118220, 611067
SH3TC2	ClinVar, OMIM, HUMSAVAR	HGNC link	5q32	2	PS118220, 613353
AARS	ClinVar, OMIM, HUMSAVAR	HGNC link	16q22.1	2	PS118220, PS308350
PRX	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.2	1	PS118220
GJB1	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq13.1	1	PS118220
PDK3	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp22.11	1	PS118220
SBF2	ClinVar, OMIM	HGNC link	11p15.4	1	PS118220
MARS	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.3	2	PS118220, 615486
TRIM2	ClinVar, OMIM, HUMSAVAR	HGNC link	4q31.3	1	PS118220
MPZ	ClinVar, OMIM, HUMSAVAR	HGNC link	1q23.3	2	PS118220, 180800

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
1p36.22	2	KIF1B, MFN2
8q21.11	2	JPH1, GDAP1
22q12.2	2	MORC2, NEFH

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
8q21	2	JPH1, GDAP1
12q24	3	COX6A1, TRPV4, HSPB8
22q12	2	MORC2, NEFH
19q13	2	MED25, PRX
1p36	3	KIF1B, MFN2, PLEKHG5

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12q2	3	COX6A1, TRPV4, HSPB8
19q1	2	MED25, PRX
1p3	4	YARS, KIF1B, MFN2, PLEKHG5
Xq2	2	AIFM1, PRPS1
22q1	3	MORC2, SBF1, NEFH
5q3	2	HARS, SH3TC2
1q2	2	LMNA, MPZ
16q2	2	KARS, AARS
10q2	2	EGR2, HK1
8q2	3	JPH1, GDAP1, NDRG1
9q3	2	SURF1, LRSAM1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
12q	4	MARS, COX6A1, TRPV4, HSPB8
9q	2	SURF1, LRSAM1
10q	2	EGR2, HK1
16q	2	KARS, AARS
22q	3	MORC2, SBF1, NEFH
1q	2	LMNA, MPZ
1p	4	YARS, KIF1B, MFN2, PLEKHG5
5q	2	HARS, SH3TC2
19q	2	MED25, PRX
11q	2	MTMR2, IGHMBP2
8q	3	JPH1, GDAP1, NDRG1
Xq	3	GJB1, AIFM1, PRPS1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	SBF2, MTMR2, IGHMBP2
10	3	EGR2, HK1, DHTKD1
12	5	FGD4, COX6A1, TRPV4, HSPB8, MARS
17	2	PMP22, NAGLU
22	3	MORC2, SBF1, NEFH
16	3	KARS, AARS, LITAF
19	3	MED25, DNM2, PRX
1	6	MPZ, YARS, MFN2, PLEKHG5, LMNA, KIF1B
5	2	HARS, SH3TC2
7	2	GARS, HSPB1
8	4	JPH1, NEFL, GDAP1, NDRG1
9	3	SURF1, VCP, LRSAM1
X	4	GJB1, AIFM1, PDK3, PRPS1

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
EGR2	YES	6	DDX20, GJB1, SCD5, IGF2, MPZ, FASLG	2	MPZ, GJB1
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	SURF1, GDAP1
SOX10	NO	11	COL11A2, GJB1, GJC2, NES, PMP22, EDNRB, MBP, MIA, MITF, MPZ, RET	3	PMP22, MPZ, GJB1
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	NDRG1, HSPB8
MYC	NO	102	CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1	2	NDRG1, SURF1

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
LITAF	YES	1	BCL6	0
NDRG1	YES	4	MYC, SIRT1, ETS1, MYCN	0
GDAP1	YES	1	YY1	0
EGR2	YES	1	GLI1	0
NEFL	YES	2	JUN, FOS	0
SURF1	YES	2	MYC, YY1	0
HSPB1	YES	2	STAT3, ESR1	0
HSPB8	YES	2	SP100, ETS1	0
VCP	YES	2	PBX1, ELF2	0
COX6A1	YES	1	MEF2A	0
MFN2	YES	1	PPARGC1A	0
PMP22	YES	3	CNOT8, CNOT7, SOX10	0
GJB1	YES	2	SOX10, EGR2	1	EGR2
MPZ	YES	2	SOX10, EGR2	1	EGR2

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
MORC2	KARS	No	1	NTRK1
MORC2	DHTKD1	No	1	NTRK1
MORC2	AIFM1	No	2	NTRK1, CUL2
MORC2	DNM2	No	2	NTRK1, HNRNPD
MORC2	NDRG1	No	1	CUL2
MORC2	HARS	No	1	NTRK1
MORC2	GDAP1	No	1	NTRK1
MORC2	PRPS1	No	1	NTRK1
MORC2	YARS	No	2	NTRK1, SORT1
MORC2	HSPB1	No	2	NTRK1, HNRNPD
MORC2	HK1	No	1	NTRK1
MORC2	VCP	No	3	NTRK1, RRBP1, CUL2
MORC2	DYNC1H1	No	3	MAX, NTRK1, HNRNPD
MORC2	LMNA	No	1	NTRK1
MORC2	GARS	No	1	NTRK1
MORC2	MFN2	No	1	NTRK1
MORC2	SBF1	No	1	NTRK1
MORC2	AARS	No	1	NTRK1
MORC2	SBF2	No	3	NTRK1, SORT1, HNRNPD
MORC2	MARS	No	1	NTRK1
KARS	MED25	No	3	MED23, MED4, ESR1
KARS	DHTKD1	No	1	NTRK1
KARS	AIFM1	No	8	ESR1, OTUB1, CUL1, ABCE1, CAND1, COPS5, FBXO6, NTRK1
KARS	DNM2	No	4	NTRK1, FN1, FBXO6, SIRT7
KARS	NDRG1	No	4	SLC25A6, HSPA4, EEF1G, DARS
KARS	HARS	No	5	NTRK1, MCM2, EEF1G, IPO7, MARS
KARS	GDAP1	No	1	NTRK1
KARS	PRPS1	No	3	NTRK1, NARS, FBXO6
KARS	NEFL	No	2	VIM, SIRT7
KARS	YARS	No	4	NTRK1, MCM2, FN1, ESR1
KARS	MTMR2	No	1	XPNPEP1
KARS	RAB7A	No	1	FN1
KARS	LRSAM1	No	2	GAG, PPME1
KARS	HSPB1	No	10	FN1, MCM2, HSPA4, RPSA, VIM, ESR1, NTRK1, COPS5, PSMA3, IPO7
KARS	NAGLU	No	1	FBXO6
KARS	HK1	No	4	NTRK1, SIRT7, RARS, ICT1
KARS	HSPB8	No	1	CIAPIN1
KARS	VCP	No	20	FN1, PIK3R3, UBE2S, ESR1, MAPK1, MCM2, HSPA4, MRPS18B, SIRT7, CCT8, MDM2, VIM, VBP1, PKN2, NTRK1, COPS5, FBXO6, PSMA3, CUL1, STAT1
KARS	DYNC1H1	No	7	FN1, PAFAH1B1, MCM2, SIRT7, VPR, COPS5, NTRK1
KARS	LMNA	No	8	FN1, MCM2, ABCE1, PPME1, SLC25A6, SIRT7, FBXO6, NTRK1
KARS	GARS	No	17	RARS, UBA1, CIAPIN1, IARS, DARS, QARS, CAND1, MARS, XPNPEP1, APEH, NARS, CARS, NTRK1, EPRS, FBXO6, PSMA3, VBP1
KARS	MFN2	No	2	NTRK1, VPR
KARS	SBF1	No	2	NTRK1, SIRT7
KARS	AARS	No	12	FN1, CIAPIN1, IARS, DARS, ABCE1, UBA1, SIRT7, NARS, LARS, NTRK1, QARS, STAT1
KARS	PDK3	No	2	CCT8, ICT1
KARS	SBF2	No	1	NTRK1
KARS	MARS	Yes	22	TXLNA, CIAPIN1, CUL1, EEF1E1, QARS, SDCCAG8, IARS, KTN1, FN1, FBXO6, GAG, AIMP2, LARS, DARS, NTRK1, PKN2, EPRS, RARS, ESR1, XPNPEP1, AIMP1, MCM2
LITAF	JPH1	No	1	ELAVL1
LITAF	AIFM1	No	1	BAG3
LITAF	NDRG1	No	1	TSG101
LITAF	EGR2	No	1	WWP2
LITAF	TRPV4	No	1	ITCH
LITAF	MTMR2	No	1	ELAVL1
LITAF	RAB7A	No	2	ELAVL1, BAG3
LITAF	LRSAM1	No	2	ATXN1, TSG101
LITAF	HSPB1	No	2	WWP1, BAG3
LITAF	HSPB8	No	1	BAG3
LITAF	VCP	No	6	ATXN1, TOM1, UBQLN1, STAM2, ELAVL1, TSG101
LITAF	GARS	No	1	TOM1
LITAF	PMP22	No	1	ELAVL1
LITAF	KIF1B	No	1	ELAVL1
LITAF	TRIM2	No	1	ELAVL1
MED25	AIFM1	No	1	ESR1
MED25	DNM2	No	1	DYNC1LI1
MED25	YARS	No	1	ESR1
MED25	HSPB1	No	1	ESR1
MED25	VCP	No	1	ESR1
MED25	DYNC1H1	No	1	DYNC1LI1
MED25	LMNA	No	1	SREBF1
MED25	MARS	No	1	ESR1
DHTKD1	AIFM1	No	2	NTRK1, DLD
DHTKD1	DNM2	No	1	NTRK1
DHTKD1	HARS	No	1	NTRK1
DHTKD1	GDAP1	No	1	NTRK1
DHTKD1	PRPS1	No	1	NTRK1
DHTKD1	YARS	No	1	NTRK1
DHTKD1	HSPB1	No	1	NTRK1
DHTKD1	HK1	No	1	NTRK1
DHTKD1	VCP	No	1	NTRK1
DHTKD1	DYNC1H1	No	1	NTRK1
DHTKD1	LMNA	No	1	NTRK1
DHTKD1	GARS	No	1	NTRK1
DHTKD1	MFN2	No	1	NTRK1
DHTKD1	SBF1	No	1	NTRK1
DHTKD1	AARS	No	1	NTRK1
DHTKD1	PDK3	No	1	DLD
DHTKD1	SBF2	No	1	NTRK1
DHTKD1	MARS	No	1	NTRK1
JPH1	NDRG1	No	1	TMEM17
JPH1	NEFL	No	1	SKAP1
JPH1	MTMR2	No	1	ELAVL1
JPH1	RAB7A	No	6	ATP6AP2, TMEM216, TCTN2, TMEM17, TCTN3, ELAVL1
JPH1	VCP	No	2	ELAVL1, TP63
JPH1	GARS	No	1	TCTN3
JPH1	SBF1	No	2	SKAP1, C1ORF186
JPH1	PMP22	No	1	ELAVL1
JPH1	KIF1B	No	2	TMED2, ELAVL1
JPH1	TRIM2	No	1	ELAVL1
AIFM1	DNM2	No	5	STAU1, NTRK1, SHC1, FBXO6, EGFR
AIFM1	NDRG1	No	4	MLH1, GSR, CUL2, SUZ12
AIFM1	HARS	No	2	NTRK1, NXF1
AIFM1	GDAP1	No	3	NTRK1, NXF1, SUZ12
AIFM1	PRPS1	No	3	NTRK1, PARK2, FBXO6
AIFM1	NEFL	No	2	PARK2, CCDC8
AIFM1	YARS	No	5	NTRK1, NXF1, ESR1, EGFR, CPOX
AIFM1	SURF1	No	1	NXF1
AIFM1	RAB7A	No	2	HSPB2, BAG3
AIFM1	LRSAM1	No	1	EGFR
AIFM1	HSPB1	No	13	NOS2, ESR1, PELO, ILK, IRAK1, ISG15, CFTR, COPS5, ARAF, EGFR, NTRK1, CUL3, BAG3
AIFM1	NAGLU	No	1	FBXO6
AIFM1	HK1	No	4	STAU1, NTRK1, PARK2, EGFR
AIFM1	HSPB8	No	1	BAG3
AIFM1	VCP	No	20	CCDC8, HSPA1A, RNF2, ADRB2, ISG15, CUL1, PARK2, NOS2, SUZ12, CUL5, CFTR, COPS5, BAG6, ESR1, NTRK1, AMFR, CUL2, FBXO6, CUL3, CDK1
AIFM1	DYNC1H1	No	15	CCDC8, CDK1, SCLT1, CUL3, SPG20, HSPA1A, SUZ12, NTRK1, COPS5, RNF2, EGFR, RYK, C20ORF24, BMI1, TUBG1
AIFM1	LMNA	No	12	PMS2, FBXO6, TOR1AIP1, ILK, ABCE1, PARK2, CCDC8, ISG15, NTRK1, H2AFX, IRAK1, NXF1
AIFM1	GARS	No	5	NTRK1, STAU1, CUL5, FBXO6, CAND1
AIFM1	MFN2	No	3	NTRK1, NXF1, PARK2
AIFM1	SBF1	No	1	NTRK1
AIFM1	PMP22	No	1	AMFR
AIFM1	KIF1B	No	1	TUBG1
AIFM1	AARS	No	4	NTRK1, NXF1, ABCE1, ISG15
AIFM1	PDK3	No	2	DLD, EGFR
AIFM1	SBF2	No	2	NTRK1, BAG6
AIFM1	MARS	No	11	RNF2, ESR1, ILK, CUL1, BRF2, OXSR1, CCDC8, EGFR, NTRK1, FBXO6, CUL3
DNM2	NDRG1	No	4	XRCC6, DDX39B, RUVBL2, RTCB
DNM2	HARS	No	2	NTRK1, SNW1
DNM2	GDAP1	No	1	NTRK1
DNM2	PRPS1	No	3	NTRK1, TCTN1, FBXO6
DNM2	NEFL	No	2	SIRT7, APP
DNM2	NEFH	No	1	GRB2
DNM2	YARS	No	5	NTRK1, FN1, VCAM1, ITGA4, EGFR
DNM2	TRPV4	No	1	SRC
DNM2	RAB7A	No	3	FN1, FBF1, CNTRL
DNM2	LRSAM1	No	1	EGFR
DNM2	HSPB1	No	9	FN1, CDC5L, HNRNPD, VCAM1, TYK2, EGFR, NTRK1, SNW1, ITGA4
DNM2	NAGLU	No	1	FBXO6
DNM2	HK1	No	8	STAU1, NPHP1, SIRT7, FBF1, CNTRL, EGFR, NTRK1, APP
DNM2	VCP	No	14	FN1, FBXO6, FBF1, VCAM1, CCT7, PLK1, GGA1, SIRT7, RUVBL2, NTRK1, DNM3, ATXN3, GRB2, ITGA4
DNM2	IGHMBP2	No	1	KIF19A
DNM2	DYNC1H1	No	17	FN1, NPHP1, EGFR, CDC5L, DCTN1, DYNC1LI1, VCAM1, HNRNPD, SIRT7, CNTRL, OFD1, DYNC1I1, RUVBL2, NTRK1, GRB2, PEX14, ITGA4
DNM2	LMNA	No	12	FN1, CDC5L, CTTN, VCAM1, PML, CD2AP, SIRT7, FBXO6, NTRK1, SNW1, ITGA4, XRCC6
DNM2	COX6A1	No	1	GRB2
DNM2	GARS	No	8	STAU1, NPHP1, CTTN, TCTN1, OFD1, FBF1, FBXO6, NTRK1
DNM2	MFN2	No	1	NTRK1
DNM2	SBF1	No	2	NTRK1, SIRT7
DNM2	KIF1B	No	1	APP
DNM2	AARS	No	5	NTRK1, FN1, VCAM1, ITGA4, SIRT7
DNM2	GJB1	No	1	APP
DNM2	PDK3	No	3	CCT7, EGFR, APP
DNM2	SBF2	No	2	NTRK1, HNRNPD
DNM2	MARS	No	6	FN1, EGFR, VCAM1, FBXO6, NTRK1, ITGA4
NDRG1	HARS	No	5	HNRNPF, THUMPD1, EEF1G, ANXA5, G6PD
NDRG1	GDAP1	No	2	SHMT2, SUZ12
NDRG1	YARS	No	3	SHMT2, PPP2R2A, ACTG1
NDRG1	RAB7A	No	6	VCP, TMEM17, EED, RPN2, AP2M1, HSPA5
NDRG1	LRSAM1	No	3	DDX5, HSP90AA1, TSG101
NDRG1	HSPB1	No	16	HSP90AA1, VCP, G6PD, HNRNPF, TARDBP, TARS, HSPA4, HNRNPH1, XPO1, HNRNPU, PKM, MME, NAMPT, USP14, IGBP1, HSPA5
NDRG1	HSPB8	No	1	XPO1
NDRG1	VCP	Yes	21	HSP90AA1, SUZ12, CANX, HIP1R, RPS6, VCP, TARDBP, ANXA5, HSPA4, HNRNPH1, RPN2, RPS9, PKM, TSG101, RUVBL2, RPS8, RPS3, HSPA5, RPL24, CUL2, SGK1
NDRG1	IGHMBP2	No	1	HNRNPU
NDRG1	DYNC1H1	No	4	RUVBL2, DDX1, SUZ12, HSP90AA1
NDRG1	LMNA	No	10	VCP, EED, XRCC6, SHMT2, FASN, SLC25A6, CDH1, CTNNB1, MME, NCL
NDRG1	GARS	No	4	SEC23A, PSMC3, TARS, DARS
NDRG1	PMP22	No	1	CANX
NDRG1	KIF1B	No	1	PSMC3
NDRG1	AARS	No	3	NIF3L1, HSP90AA1, DARS
NDRG1	PDK3	No	1	VCP
NDRG1	SBF2	No	1	XPO1
NDRG1	MARS	No	1	DARS
NDRG1	TRIM2	No	2	BCL2L11, HSP90AA1
HARS	GDAP1	No	2	NTRK1, NXF1
HARS	PRPS1	No	2	NTRK1, PFDN1
HARS	YARS	No	4	NTRK1, MCM2, NXF1, MOV10
HARS	SURF1	No	2	NXF1, MOV10
HARS	HSPB1	No	11	SARS, G6PD, MCM2, HNRNPF, GARS, EEF1B2, IPO7, AARSD1, NTRK1, SNW1, EFTUD2
HARS	HK1	No	1	NTRK1
HARS	VCP	No	5	NTRK1, PSMC5, MCM2, ANXA5, CALU
HARS	DYNC1H1	No	3	NTRK1, TNIK, MCM2
HARS	LMNA	No	6	MCM2, C9ORF78, NTRK1, SNW1, NXF1, MOV10
HARS	GARS	Yes	4	NTRK1, SHMT1, TTC1, MARS
HARS	MFN2	No	2	NTRK1, NXF1
HARS	SBF1	No	1	NTRK1
HARS	AARS	No	7	CALU, WARS, GARS, NTRK1, NXF1, NSUN2, MOV10
HARS	SBF2	No	1	NTRK1
HARS	MARS	Yes	3	NTRK1, MCM2, GARS
HARS	TRIM2	No	1	TNIK
GDAP1	PRPS1	No	1	NTRK1
GDAP1	YARS	No	3	NTRK1, NXF1, SHMT2
GDAP1	SURF1	No	1	NXF1
GDAP1	RAB7A	No	1	FAF2
GDAP1	HSPB1	No	1	NTRK1
GDAP1	HK1	No	1	NTRK1
GDAP1	VCP	No	4	NTRK1, FAF2, SUZ12, TUBB
GDAP1	DYNC1H1	No	2	NTRK1, SUZ12
GDAP1	LMNA	No	3	NTRK1, NXF1, SHMT2
GDAP1	GARS	No	1	NTRK1
GDAP1	MFN2	No	2	NTRK1, NXF1
GDAP1	SBF1	No	1	NTRK1
GDAP1	AARS	No	2	NTRK1, NXF1
GDAP1	SBF2	No	1	NTRK1
GDAP1	MARS	No	1	NTRK1
PRPS1	NEFL	No	1	PARK2
PRPS1	YARS	No	1	NTRK1
PRPS1	HSPB1	No	5	NTRK1, YWHAE, TUBA4A, RPAP3, PRPF19
PRPS1	NAGLU	No	1	FBXO6
PRPS1	HK1	No	2	NTRK1, PARK2
PRPS1	VCP	No	8	SMURF1, PRPF19, YWHAE, PARK2, NMD3, FBXO6, NTRK1, UBB
PRPS1	DYNC1H1	No	2	NTRK1, POC5
PRPS1	LMNA	No	3	NTRK1, PARK2, FBXO6
PRPS1	GARS	No	7	POC5, GORASP2, TCTN1, NMD3, FBXO6, NTRK1, NARS
PRPS1	MFN2	No	2	NTRK1, PARK2
PRPS1	SBF1	No	1	NTRK1
PRPS1	KIF1B	No	1	YWHAE
PRPS1	AARS	No	4	NTRK1, NARS, NMD3, SBDS
PRPS1	SBF2	No	1	NTRK1
PRPS1	MARS	No	2	NTRK1, FBXO6
EGR2	HSPB1	No	3	UBE2I, MED31, HN1L
EGR2	LMNA	No	3	UBE2I, HCFC1, HN1L
EGR2	KIF1B	No	1	UBE2I
NEFL	NEFH	Yes	3	GAN, C16ORF70, PKN1
NEFL	LRSAM1	No	2	USP2, TERF1
NEFL	HSPB1	No	4	VIM, CCNC, OBSL1, CRYAB
NEFL	HK1	No	3	PARK2, SIRT7, APP
NEFL	HSPB8	No	1	CRYAB
NEFL	VCP	No	9	OBSL1, SPTAN1, PARK2, SIRT7, PPP1R18, VIM, CCDC8, YWHAG, PPP1CC
NEFL	DYNC1H1	No	3	OBSL1, SIRT7, CCDC8
NEFL	LMNA	No	5	PARK2, PPP1CC, OBSL1, SIRT7, CCDC8
NEFL	MFN2	No	1	PARK2
NEFL	SBF1	No	2	SKAP1, SIRT7
NEFL	KIF1B	No	2	YWHAG, APP
NEFL	AARS	No	1	SIRT7
NEFL	GJB1	No	1	APP
NEFL	PDK3	No	1	APP
NEFL	MARS	No	1	CCDC8
NEFH	VCP	No	1	GRB2
NEFH	DYNC1H1	No	1	GRB2
NEFH	COX6A1	No	1	GRB2
YARS	SURF1	No	2	NXF1, MOV10
YARS	RAB7A	No	3	EIF1B, EEF1A1, FN1
YARS	LRSAM1	No	1	EGFR
YARS	HSPB1	No	13	FN1, HSPA8, EGFR, AHNAK, MCM2, VCAM1, NRD1, HNRNPH2, XRCC5, ESR1, NTRK1, EEF1A1, ITGA4
YARS	HK1	No	4	NTRK1, EGFR, CDK2, PROSC
YARS	VCP	No	13	FN1, HSPA8, SAP18, CDK2, VCAM1, ARF6, G3BP2, HNRNPH2, ACTB, ESR1, NTRK1, MCM2, ITGA4
YARS	DYNC1H1	Yes	11	FN1, CDK2, FOXB1, FOXL1, ARF6, VCAM1, XRCC5, EGFR, NTRK1, MCM2, ITGA4
YARS	LMNA	No	10	FN1, CDK2, SHMT2, MCM2, VCAM1, MOV10, ENO1, NTRK1, NXF1, ITGA4
YARS	GARS	No	2	NTRK1, CDK2
YARS	MFN2	No	2	NTRK1, NXF1
YARS	SBF1	No	1	NTRK1
YARS	KIF1B	No	1	EEF1A1
YARS	AARS	No	8	FN1, CDK2, VCAM1, MOV10, ENO1, NTRK1, NXF1, ITGA4
YARS	PDK3	No	1	EGFR
YARS	SBF2	No	2	NTRK1, SORT1
YARS	MARS	No	7	FN1, ESR1, MCM2, VCAM1, EGFR, NTRK1, ITGA4
SURF1	RAB7A	No	3	ABCD3, NDUFB8, NDUFV2
SURF1	HSPB1	No	1	PTGES3
SURF1	VCP	No	2	ABCC1, PTGES3
SURF1	LMNA	No	2	NXF1, MOV10
SURF1	MFN2	No	1	NXF1
SURF1	AARS	No	2	NXF1, MOV10
TRPV4	VCP	No	2	ARRB2, OS9
TRPV4	DYNC1H1	No	1	ARRB2
MTMR2	RAB7A	No	1	ELAVL1
MTMR2	LRSAM1	Yes	6	CTPS2, HSF1, EHD4, MTMR2, LRSAM1, PLIN3
MTMR2	HSPB1	No	2	SBF1, HSF1
MTMR2	VCP	No	2	ELAVL1, RFC5
MTMR2	DYNC1H1	No	1	UNK
MTMR2	GARS	No	2	UNK, XPNPEP1
MTMR2	SBF1	Yes	1	MTMR2
MTMR2	PMP22	No	1	ELAVL1
MTMR2	KIF1B	No	1	ELAVL1
MTMR2	AARS	No	1	HSF1
MTMR2	MARS	No	1	XPNPEP1
MTMR2	TRIM2	No	1	ELAVL1
RAB7A	LRSAM1	No	1	VPS11
RAB7A	HSPB1	No	14	BMPR1A, VCP, HSPA9, UCHL5, GDI2, FN1, EIF4G2, EEF1A1, ATF2, RPA1, RPA2, HSPA5, RPA3, BAG3
RAB7A	HK1	No	4	FBF1, VDAC1, CNTRL, ATF2
RAB7A	HSPB8	No	1	BAG3
RAB7A	VCP	Yes	22	FN1, VCP, RAB10, HNRNPK, CAV1, HSPA5, PHB, HSP90B1, VPS18, SNX3, PSMA7, RAB11B, ELAVL1, FBF1, SLC25A3, PPP2R1A, CHMP4B, FUS, ANXA2, RPN2, FAF2, CUL7
RAB7A	DYNC1H1	No	6	FN1, LRRK2, FUS, CNTRL, RPA2, CUL7
RAB7A	LMNA	No	9	PHB, FN1, VCP, FUS, UCHL5, RPA1, EED, KRTAP10-3, CUL7
RAB7A	GARS	No	3	TCTN3, FBF1, CORO1C
RAB7A	PMP22	No	1	ELAVL1
RAB7A	KIF1B	No	2	EEF1A1, ELAVL1
RAB7A	AARS	No	1	FN1
RAB7A	GJB1	No	2	JUP, CAV1
RAB7A	PDK3	No	1	VCP
RAB7A	MARS	No	3	FN1, HSP90B1, CUL7
RAB7A	TRIM2	No	2	PDHA1, ELAVL1
LRSAM1	HSPB1	No	5	UBE2N, KLC1, EGFR, HSP90AA1, HSF1
LRSAM1	HK1	No	1	EGFR
LRSAM1	VCP	No	5	ATXN1, UBE2J1, ATXN7, HSP90AA1, TSG101
LRSAM1	DYNC1H1	No	3	NINL, EGFR, HSP90AA1
LRSAM1	LMNA	No	1	PPME1
LRSAM1	GARS	No	1	HSPBP1
LRSAM1	MFN2	No	1	UBE2N
LRSAM1	SBF1	No	1	MTMR2
LRSAM1	KIF1B	No	2	MAGEA1, NINL
LRSAM1	AARS	No	3	ANKMY2, HSP90AA1, HSF1
LRSAM1	PDK3	No	1	EGFR
LRSAM1	MARS	No	2	GAG, EGFR
LRSAM1	TRIM2	No	9	UBE2D2, UBE2D1, UBE2K, UBE2H, UBE2D3, UBE2D4, HSP90AA1, UBE2E1, UBE2W
HSPB1	HK1	No	5	NTRK1, EGFR, ATF2, AHCY, AKT1
HSPB1	HSPB8	Yes	8	CRYAB, HSPB6, ASB4, XPO1, HSPB1, HSPB8, SNCA, BAG3
HSPB1	VCP	Yes	71	PEX19, HNRNPA1, AKT1, STIP1, HUWE1, TARDBP, YWHAE, CDK1, TP53, HNRNPH2, EZH2, NAPA, HDLBP, TUBA1C, HSP90AB1, PSMC1, HSPA5, ACTN4, ATXN10, STUB1, HSP90AA1, PTGES3, VCP, PRKCD, SRRM2, YWHAH, MCM2, HAUS1, CFTR, NPM1, IRS4, COPS5, YWHAB, IQCB1, FN1, ITGA4, UFD1L, OBSL1, CALR, ACTN1, MRPS23, EIF4A2, SIK2, ISG15, UBC, PSMA6, HNRNPH3, ARIH1, VCAM1, UBL4A, TKT, FLNB, ANAPC7, NOS2, HSPA8, PRPF19, STMN1, KCMF1, PSMA3, HSPA4, BTRC, HNRNPH1, HSPB1, PKM, YWHAZ, ESR1, NTRK1, VIM, YWHAQ, RAD23A, CUL3
HSPB1	IGHMBP2	No	1	HNRNPU
HSPB1	DYNC1H1	No	21	PPP2R3C, FN1, STRN, CDC5L, PRKCD, VCAM1, MCM2, CUL3, HDAC6, OBSL1, HSP90AA1, RPA2, COPS5, ITGA4, EGFR, NTRK1, SNCA, HNRNPD, YWHAQ, MYC, XRCC5
HSPB1	LMNA	No	32	FN1, HNRNPA1, CDC5L, UCHL5, TOX4, TP53, RPA1, ISG15, SNW1, SRRM2, LIMK2, EIF5, VCP, CRK, MCM2, VCAM1, EEF1D, HNRNPA2B1, HN1L, ITGA4, OBSL1, WWOX, MRGBP, IRAK1, MYC, SF3B3, ILK, SUPT5H, MME, NTRK1, UBE2I, YWHAQ
HSPB1	GARS	Yes	8	UFD1L, ZYX, TARS, EEF1D, HSPB1, UGDH, NTRK1, PSMA3
HSPB1	MFN2	No	4	NTRK1, HUWE1, UBE2N, HDAC6
HSPB1	SBF1	Yes	2	NTRK1, HSPB1
HSPB1	PMP22	No	1	PEX19
HSPB1	KIF1B	No	6	YWHAH, KIAA0368, YWHAE, UBE2I, EEF1A1, YWHAB
HSPB1	AARS	No	9	FN1, HSP90AB1, HSF1, VCAM1, HSP90AA1, GARS, ISG15, NTRK1, ITGA4
HSPB1	PDK3	No	3	ACAP2, EGFR, VCP
HSPB1	SBF2	No	4	NTRK1, UBC, HNRNPD, XPO1
HSPB1	MARS	No	13	FN1, ESR1, ILK, VCAM1, MCM2, HUWE1, EIF2S1, GARS, CUL3, EGFR, NTRK1, MYC, ITGA4
HSPB1	TRIM2	No	1	HSP90AA1
NAGLU	VCP	No	2	TMED10, FBXO6
NAGLU	LMNA	No	1	FBXO6
NAGLU	GARS	No	1	FBXO6
NAGLU	MARS	No	1	FBXO6
HK1	VCP	No	12	UBXN1, GBAS, CDK2, PDCD10, PARK2, FBF1, SIRT7, UBA5, AKT1, NTRK1, PLAA, NSFL1C
HK1	DYNC1H1	No	6	EGFR, CDK2, SIRT7, CNTRL, NPHP1, NTRK1
HK1	LMNA	No	4	NTRK1, PARK2, SIRT7, CDK2
HK1	GARS	No	6	STAU1, RARS, CDK2, FBF1, NPHP1, NTRK1
HK1	MFN2	No	2	NTRK1, PARK2
HK1	SBF1	No	2	NTRK1, SIRT7
HK1	KIF1B	No	1	APP
HK1	AARS	No	3	NTRK1, SIRT7, CDK2
HK1	GJB1	No	1	APP
HK1	PDK3	No	3	EGFR, APP, ICT1
HK1	SBF2	No	1	NTRK1
HK1	MARS	No	3	NTRK1, EGFR, RARS
HSPB8	VCP	No	2	DSTN, HSPB1
HSPB8	DYNC1H1	No	1	SNCA
HSPB8	GARS	No	3	HSPB1, HSPB2, CIAPIN1
HSPB8	SBF1	No	1	HSPB1
HSPB8	AARS	No	1	CIAPIN1
HSPB8	SBF2	No	1	XPO1
HSPB8	MARS	No	1	CIAPIN1
VCP	DYNC1H1	No	36	HSPA1A, DYNC1LI1, NUMA1, FN1, SUZ12, FBXW11, TNKS1BP1, CRY2, PRKCD, ARRB2, VCAM1, SIRT7, CSNK2B, DYNC1I2, COPS5, BRCA1, SPRTN, OBSL1, NME2, PRMT5, HSP90AA1, EPPK1, RNF2, RUVBL2, CDK1, CDK2, FUS, ARF6, CCDC8, CUL3, NTRK1, GRB2, ITGA4, YWHAQ, MCM2, CUL7
VCP	LMNA	Yes	31	FN1, HNRNPA1, RIF1, LMNB2, NUMA1, TP53, ISG15, SRRM2, PHB, VCP, MCM2, VCAM1, SIRT7, NPLOC4, FBXO6, PPP1CC, ITGA4, OBSL1, LMNA, SMARCA5, CDK2, FUS, RBBP4, UBE2M, PARK2, CCDC8, RANBP2, NTRK1, DGCR14, YWHAQ, CUL7
VCP	COX6A1	No	1	GRB2
VCP	GARS	No	15	UFD1L, CUL5, CTNNA1, CDK2, CRY2, HDAC6, NPLOC4, TOM1, FBF1, HSPB1, NMD3, FBXO6, NTRK1, PSMA3, VBP1
VCP	MFN2	No	3	NTRK1, PARK2, HUWE1
VCP	SBF1	No	5	NTRK1, CDKN1A, HSPB1, SIRT7, FBXW11
VCP	PMP22	No	5	SYVN1, ELAVL1, PEX19, AMFR, CANX
VCP	KIF1B	No	6	YWHAH, YWHAE, ELAVL1, YWHAG, BRCA1, YWHAB
VCP	PLEKHG5	No	1	LNX1
VCP	AARS	No	14	HSP90AA1, FN1, ISG15, CDK2, TPD52L2, SIRT7, VCAM1, TOM1L1, NMD3, STAT1, HSP90AB1, NTRK1, CALU, ITGA4
VCP	GJB1	No	1	CAV1
VCP	PDK3	Yes	9	CCT7, VCP, CCT5, CCT3, CCT2, CCT8, TCP1, CCT4, CCT6A
VCP	SBF2	No	4	NTRK1, UBC, BAG6, FBXW11
VCP	MARS	No	21	CCDC8, FN1, RNF2, PKN2, CRY2, VCAM1, CCT3, CUL3, HUWE1, MCC, HSP90B1, CUL7, CUL1, EEA1, ESR1, NTRK1, HDAC5, FBXO6, RPL13, MCM2, ITGA4
VCP	TRIM2	No	2	ELAVL1, HSP90AA1
IGHMBP2	LMNA	No	1	NELFE
IGHMBP2	KIF1B	No	1	SMC6
DYNC1H1	LMNA	No	22	FN1, CDC5L, NUMA1, NUP133, SAP30BP, MCM2, VCAM1, SIRT7, DYNLT1, ITGA4, OBSL1, TOR1A, USP7, CENPE, CDK2, FUS, FLNA, CCDC8, NTRK1, MYC, YWHAQ, CUL7
DYNC1H1	COX6A1	No	2	HTT, GRB2
DYNC1H1	GARS	No	10	UNK, CDK2, CRY2, SERBP1, RPGRIP1L, NCBP1, OFD1, NPHP1, NTRK1, POC5
DYNC1H1	MFN2	No	3	NTRK1, VPR, HDAC6
DYNC1H1	SBF1	No	3	NTRK1, SIRT7, FBXW11
DYNC1H1	KIF1B	No	3	BRCA1, NINL, TUBG1
DYNC1H1	AARS	No	9	FN1, CDK2, CALML3, VCAM1, SIRT7, HSP90AA1, TPD52, NTRK1, ITGA4
DYNC1H1	PDK3	No	1	EGFR
DYNC1H1	SBF2	No	4	SYNCRIP, NTRK1, HNRNPD, FBXW11
DYNC1H1	MARS	No	13	CCDC8, FN1, CUL7, CRY2, MCM2, VCAM1, RNF2, PIN4, EGFR, NTRK1, MYC, CUL3, ITGA4
DYNC1H1	TRIM2	No	2	TNIK, HSP90AA1
LMNA	GARS	No	9	CTTN, CDK2, NUP50, EEF1D, NPLOC4, PPM1G, GTF2A1, NTRK1, FBXO6
LMNA	MFN2	No	3	NTRK1, NXF1, PARK2
LMNA	SBF1	No	2	NTRK1, SIRT7
LMNA	KIF1B	No	1	UBE2I
LMNA	AARS	No	11	FN1, CDK2, ABCE1, VCAM1, SIRT7, MOV10, ENO1, ISG15, NTRK1, NXF1, ITGA4
LMNA	PDK3	No	1	VCP
LMNA	SBF2	No	1	NTRK1
LMNA	MARS	No	11	FN1, ILK, MCM2, VCAM1, CCDC8, CUL7, FBXO6, NTRK1, MYC, SDCBP, ITGA4
GARS	MFN2	No	1	NTRK1
GARS	SBF1	No	2	NTRK1, HSPB1
GARS	KIF1B	No	1	PSMC3
GARS	AARS	Yes	12	ASNS, IARS, DARS, CDK2, TARSL2, QARS, UBA1, NMD3, NARS, CIAPIN1, NTRK1, PDIA3
GARS	SBF2	No	1	NTRK1
GARS	MARS	Yes	13	DARS, CRY2, CRY1, GFPT1, QARS, RARS, XPNPEP1, IARS, HARS, CIAPIN1, NTRK1, EPRS, FBXO6
MFN2	SBF1	No	1	NTRK1
MFN2	AARS	No	2	NTRK1, NXF1
MFN2	SBF2	No	1	NTRK1
MFN2	MARS	No	2	NTRK1, HUWE1
SBF1	AARS	No	2	NTRK1, SIRT7
SBF1	SBF2	No	4	NTRK1, PMS1, MTMR2, FBXW11
SBF1	MARS	No	1	NTRK1
PMP22	KIF1B	No	1	ELAVL1
PMP22	TRIM2	No	1	ELAVL1
PMP22	MPZ	Yes	0
KIF1B	GJB1	No	1	APP
KIF1B	PDK3	No	1	APP
KIF1B	MARS	No	1	GIPC1
KIF1B	TRIM2	No	1	ELAVL1
AARS	SBF2	No	1	NTRK1
AARS	MARS	No	10	FN1, IARS, DARS, VCAM1, QARS, GARS, CIAPIN1, NTRK1, ITGA4, LARS
AARS	TRIM2	No	1	HSP90AA1
GJB1	PDK3	No	1	APP
PDK3	MARS	No	2	CCT3, EGFR
SBF2	MARS	No	1	NTRK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MORC2	KARS	No	-	1	UBC
MORC2	MED25	No	-	1	UBC
MORC2	AIFM1	No	-	1	UBC
MORC2	DNM2	No	-	1	UBC
MORC2	HARS	No	-	1	UBC
MORC2	TRPV4	No	-	1	UBC
MORC2	LRSAM1	No	-	1	UBC
MORC2	HK1	No	-	1	UBC
MORC2	VCP	No	-	1	UBC
MORC2	DYNC1H1	No	-	1	UBC
MORC2	SPG11	No	-	1	UBC
MORC2	AARS	No	-	1	UBC
MORC2	MARS	No	-	1	UBC
KARS	MED25	No	-	1	UBC
KARS	AIFM1	No	-	1	UBC
KARS	DNM2	No	-	1	UBC
KARS	HARS	No	-	1	UBC
KARS	TRPV4	No	-	1	UBC
KARS	LRSAM1	No	-	1	UBC
KARS	HK1	No	-	1	UBC
KARS	VCP	No	-	1	UBC
KARS	DYNC1H1	No	-	1	UBC
KARS	SPG11	No	-	1	UBC
KARS	AARS	No	-	1	UBC
KARS	MARS	Yes	binding	10	EEF1E1, RARS, DARS, QARS, IARS, LARS, UBC, EPRS, AIMP1, AIMP2
MED25	AIFM1	No	-	1	UBC
MED25	DNM2	No	-	1	UBC
MED25	HARS	No	-	1	UBC
MED25	TRPV4	No	-	1	UBC
MED25	LRSAM1	No	-	1	UBC
MED25	HK1	No	-	1	UBC
MED25	VCP	No	-	1	UBC
MED25	DYNC1H1	No	-	1	UBC
MED25	SPG11	No	-	1	UBC
MED25	AARS	No	-	1	UBC
MED25	MARS	No	-	1	UBC
DHTKD1	PDK3	No	-	2	DLD, PDHX
AIFM1	DNM2	No	-	1	UBC
AIFM1	HARS	No	-	1	UBC
AIFM1	TRPV4	No	-	1	UBC
AIFM1	LRSAM1	No	-	1	UBC
AIFM1	HK1	No	-	1	UBC
AIFM1	VCP	No	-	1	UBC
AIFM1	DYNC1H1	No	-	2	UBC, TUBA3E
AIFM1	SPG11	No	-	1	UBC
AIFM1	AARS	No	-	1	UBC
AIFM1	MARS	No	-	1	UBC
DNM2	HARS	No	-	1	UBC
DNM2	GDAP1	No	-	1	FIS1
DNM2	TRPV4	No	-	3	SRC, UBC, PACSIN3
DNM2	FGD4	No	-	2	RAC1, RAC3
DNM2	LRSAM1	No	-	1	UBC
DNM2	HK1	No	-	1	UBC
DNM2	VCP	No	-	2	UBC, CAV1
DNM2	DYNC1H1	No	-	3	UBC, NDEL1, HLA-DRB5
DNM2	SPG11	No	-	1	UBC
DNM2	AARS	No	-	1	UBC
DNM2	MARS	No	-	1	UBC
HARS	TRPV4	No	-	1	UBC
HARS	LRSAM1	No	-	1	UBC
HARS	HK1	No	-	1	UBC
HARS	VCP	No	-	1	UBC
HARS	DYNC1H1	No	-	1	UBC
HARS	SPG11	No	-	1	UBC
HARS	AARS	No	-	1	UBC
HARS	MARS	No	-	1	UBC
NEFH	VCP	No	-	1	CDK1
NEFH	DYNC1H1	No	-	1	CDK1
SURF1	COX6A1	No	-	3	MT-CO1, COX5A, MT-CO2
TRPV4	LRSAM1	No	-	1	UBC
TRPV4	HK1	No	-	1	UBC
TRPV4	VCP	No	-	2	UBC, OS9
TRPV4	DYNC1H1	No	-	1	UBC
TRPV4	SPG11	No	-	1	UBC
TRPV4	AARS	No	-	1	UBC
TRPV4	MARS	No	-	1	UBC
LRSAM1	HK1	No	-	1	UBC
LRSAM1	VCP	No	-	2	UBC, HSP90AA1
LRSAM1	DYNC1H1	No	-	3	UBC, PRKAR2B, HSP90AA1
LRSAM1	SPG11	No	-	1	UBC
LRSAM1	AARS	No	-	1	UBC
LRSAM1	MARS	No	-	3	UBC, HSP90AA1, HSP90AB1
HK1	VCP	No	-	1	UBC
HK1	DYNC1H1	No	-	1	UBC
HK1	SPG11	No	-	1	UBC
HK1	AARS	No	-	1	UBC
HK1	MARS	No	-	1	UBC
VCP	DYNC1H1	No	-	5	PPP2R1A, HTT, CDK1, UBC, HSP90AA1
VCP	SPG11	No	-	1	UBC
VCP	AARS	No	-	1	UBC
VCP	MARS	No	-	3	UBC, UBB, HSP90AA1
DYNC1H1	SPG11	No	-	1	UBC
DYNC1H1	AARS	No	-	1	UBC
DYNC1H1	MARS	No	-	2	UBC, HSP90AA1
SPG11	AARS	No	-	1	UBC
SPG11	MARS	No	-	1	UBC
AARS	MARS	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
KARS	MARS	Yes	Multisynthetase complex	9	EEF1E1, RARS, DARS, QARS, IARS, LARS, EPRS, AIMP1, AIMP2
HSPB8	VCP	No	-	1	HSPA8
HSPB8	DYNC1H1	No	-	1	HSPA8
VCP	DYNC1H1	No	-	1	HSPA8
DYNC1H1	LMNA	No	-	1	TOP2A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
KARS	PRPS1	No	1	NARS
KARS	GARS	No	8	UBA1, RARS, DARS, IARS, VBP1, QARS, EPRS, NARS
KARS	AARS	No	6	UBA1, IARS, DARS, QARS, NARS, LARS
KARS	MARS	Yes	9	EEF1E1, RARS, DARS, QARS, IARS, LARS, EPRS, AIMP1, AIMP2
NDRG1	HARS	No	1	ANXA5
PRPS1	GARS	No	1	NARS
PRPS1	AARS	No	1	NARS
YARS	DYNC1H1	Yes	1	XRCC5
HSPB8	VCP	No	1	DSTN
GARS	AARS	Yes	6	ASNS, IARS, DARS, UBA1, QARS, NARS
GARS	MARS	No	5	EPRS, IARS, QARS, RARS, DARS
AARS	MARS	No	4	IARS, QARS, DARS, LARS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
MPZ	PMP22	yes, they interact	The PMP22 protein is characterized by four transmembrane domains, two extracellular loops (ECL1 and ECL2), and one intracellular loop. ECL1 has been suggested to mediate a homophilic interaction between two PMP22 proteins, whereas ECL2 has been shown to mediate a heterophilic interaction between PMP22 protein and myelin protein zero (MPZ).

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Aminoacyl-tRNA biosynthesis	hsa00970	7.31	6	KARS, YARS, GARS, MARS, HARS, AARS
Metabolic pathways	hsa01100	2.49	4	PRPS1, COX6A1, HK1, NAGLU
Salmonella infection	hsa05132	6.29	2	DYNC1H1, RAB7A
Carbon metabolism	hsa01200	6.03	2	PRPS1, HK1
Amoebiasis	hsa05146	5.82	2	RAB7A, HSPB1
Endocytosis	hsa04144	4.92	2	RAB7A, DNM2
Amyotrophic lateral sclerosis (ALS)	hsa05014	7.01	2	NEFL, NEFH
Phagosome	hsa04145	5.27	2	DYNC1H1, RAB7A

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Aminoacyl-tRNA biosynthesis (hsa00970)	-	7.31	0.0	KARS, YARS, GARS, MARS, HARS, AARS

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Gene Expression	R-HSA-74160	2.72	10	YARS, KARS, SURF1, HARS, COX6A1, MED25, HSPB1, MARS, AARS, GARS
Metabolism	R-HSA-1430728	2.34	10	DNM2, PRPS1, COX6A1, MTMR2, HK1, FIG4, NAGLU, MED25, SURF1, PDK3
Signal Transduction	R-HSA-162582	1.78	7	DNM2, VCP, PLEKHG5, NEFL, HSPB1, PDK3, FGD4
Cytosolic tRNA aminoacylation	R-HSA-379716	8.4	6	KARS, YARS, GARS, MARS, HARS, AARS
Immune System	R-HSA-168256	2.37	6	DNM2, DYNC1H1, NEFL, LRSAM1, TRIM2, RAB7A
tRNA Aminoacylation	R-HSA-379724	7.59	6	KARS, YARS, GARS, MARS, HARS, AARS
Adaptive Immune System	R-HSA-1280218	3.19	4	DYNC1H1, RAB7A, LRSAM1, DNM2
Developmental Biology	R-HSA-1266738	3.48	4	NEFL, MED25, EGR2, DNM2
Signalling by NGF	R-HSA-166520	4.23	4	PLEKHG5, NEFL, DNM2, FGD4
Metabolism of carbohydrates	R-HSA-71387	4.93	3	PRPS1, HK1, NAGLU
Signaling by GPCR	R-HSA-372790	2.68	3	PLEKHG5, NEFL, FGD4
Generic Transcription Pathway	R-HSA-212436	3.86	3	SURF1, MED25, COX6A1
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	3	SURF1, PDK3, COX6A1
MHC class II antigen presentation	R-HSA-2132295	6.01	3	DYNC1H1, RAB7A, DNM2
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	FIG4, MTMR2, MED25
Transcriptional Regulation by TP53	R-HSA-3700989	6.73	2	SURF1, COX6A1
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7	2	MED25, EGR2
Signaling by Rho GTPases	R-HSA-194315	4.43	2	PLEKHG5, FGD4
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	HK1, TRPV4
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	NEFL, TRIM2
p75 NTR receptor-mediated signalling	R-HSA-193704	6.59	2	PLEKHG5, FGD4
Cell Cycle	R-HSA-1640170	3.89	2	DYNC1H1, LMNA
Disease	R-HSA-1643685	3.33	2	NAGLU, VCP
NRAGE signals death through JNK	R-HSA-193648	7.49	2	PLEKHG5, FGD4
Synthesis of PIPs at the early endosome membrane	R-HSA-1660516	9.28	2	FIG4, MTMR2
Synthesis of PIPs at the late endosome membrane	R-HSA-1660517	9.66	2	FIG4, MTMR2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	R-HSA-163200	6.12	2	SURF1, COX6A1
MAPK family signaling cascades	R-HSA-5683057	4.89	2	NEFL, HSPB1
Signaling by VEGF	R-HSA-194138	4.66	2	NEFL, HSPB1
Gap junction trafficking	R-HSA-190828	7.59	2	DNM2, GJB1
Phospholipid metabolism	R-HSA-1483257	5.83	2	FIG4, MTMR2
PI Metabolism	R-HSA-1483255	7.31	2	FIG4, MTMR2
Cell Cycle, Mitotic	R-HSA-69278	4.16	2	DYNC1H1, LMNA
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73	2	SURF1, COX6A1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	NEFL, HSPB1
Respiratory electron transport	R-HSA-611105	6.44	2	SURF1, COX6A1
G alpha (12/13) signalling events	R-HSA-416482	6.75	2	PLEKHG5, FGD4
GPCR downstream signaling	R-HSA-388396	3.07	2	PLEKHG5, FGD4
Innate Immune System	R-HSA-168249	3.17	2	NEFL, DNM2
Membrane Trafficking	R-HSA-199991	5.26	2	DNM2, GJB1
Gap junction trafficking and regulation	R-HSA-157858	7.52	2	DNM2, GJB1
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	2	NEFL, DNM2
Vesicle-mediated transport	R-HSA-5653656	4.33	2	DNM2, GJB1
Mitochondrial tRNA aminoacylation	R-HSA-379726	8.59	2	GARS, KARS
Rho GTPase cycle	R-HSA-194840	6.04	2	PLEKHG5, FGD4
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.05	2	PLEKHG5, FGD4
Axon guidance	R-HSA-422475	3.93	2	NEFL, DNM2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cytosolic tRNA aminoacylation (R-HSA-379716)	-	8.4	0.0	KARS, YARS, GARS, MARS, HARS, AARS
tRNA Aminoacylation (R-HSA-379724)	-	7.59	0.0	KARS, YARS, GARS, MARS, HARS, AARS

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	40	PRPS1, GJB1, MFN2, MARS, LRSAM1, GARS, AARS, AIFM1, MORC2, FGD4, SBF2, TRPV4, VCP, HARS, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, YARS, DYNC1H1, HK1, DNM2, TRIM2, NEFH, SPG11, DHTKD1, KARS, NDRG1, NEFL, MTMR2, FIG4, EGR2, SURF1, HSPB8, RAB7A, PMP22
protein binding (GO:0005515)	0.46	35	PRPS1, GJB1, MFN2, LRSAM1, EGR2, AIFM1, FGD4, SBF2, TRPV4, VCP, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, YARS, DYNC1H1, HK1, DNM2, TRIM2, NEFH, SPG11, KARS, NDRG1, NEFL, MTMR2, FIG4, GARS, SURF1, HSPB8, RAB7A, PMP22
catalytic activity (GO:0003824)	1.05	29	PRPS1, COX6A1, GDAP1, MFN2, MARS, LRSAM1, GARS, AARS, AIFM1, KIF1B, DNM2, VCP, HARS, EGR2, SBF1, PDK3, IGHMBP2, YARS, DYNC1H1, HK1, TRIM2, DHTKD1, KARS, MTMR2, FIG4, NAGLU, SURF1, HSPB8, RAB7A
organic cyclic compound binding (GO:0097159)	1.05	21	DNM2, YARS, VCP, KARS, TRPV4, DYNC1H1, DHTKD1, MFN2, HK1, GARS, EGR2, IGHMBP2, HARS, HSPB1, MARS, AARS, PRPS1, RAB7A, AIFM1, PDK3, KIF1B
heterocyclic compound binding (GO:1901363)	1.06	21	DNM2, PRPS1, KARS, VCP, DYNC1H1, MFN2, HK1, GARS, EGR2, IGHMBP2, HARS, HSPB1, MARS, AARS, TRPV4, RAB7A, PDK3, AIFM1, DHTKD1, KIF1B, YARS
small molecule binding (GO:0036094)	1.89	19	DNM2, PRPS1, KARS, VCP, DYNC1H1, MFN2, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, AIFM1, DHTKD1, KIF1B, YARS
nucleoside phosphate binding (GO:1901265)	1.96	18	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, AIFM1, PDK3, KIF1B, YARS
nucleotide binding (GO:0000166)	1.96	18	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, AIFM1, PDK3, KIF1B, YARS
carbohydrate derivative binding (GO:0097367)	2.03	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
purine nucleoside binding (GO:0001883)	2.22	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
ribonucleoside binding (GO:0032549)	2.22	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
purine ribonucleotide binding (GO:0032555)	2.2	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
purine nucleotide binding (GO:0017076)	2.19	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
purine ribonucleoside binding (GO:0032550)	2.22	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
ribonucleotide binding (GO:0032553)	2.19	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
nucleoside binding (GO:0001882)	2.21	17	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
adenyl ribonucleotide binding (GO:0032559)	2.41	14	PRPS1, KARS, VCP, DYNC1H1, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, PDK3, KIF1B, YARS
ATP binding (GO:0005524)	2.43	14	PRPS1, KARS, VCP, DYNC1H1, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, PDK3, KIF1B, YARS
adenyl nucleotide binding (GO:0030554)	2.4	14	PRPS1, VCP, KARS, DYNC1H1, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, PDK3, KIF1B, YARS
enzyme binding (GO:0019899)	2.27	13	MFN2, SBF2, TRPV4, VCP, NDRG1, NEFL, DNM2, EGR2, HSPB1, LMNA, RAB7A, NEFH, FGD4
hydrolase activity (GO:0016787)	1.9	12	DNM2, SBF1, VCP, DYNC1H1, MFN2, MTMR2, NAGLU, FIG4, IGHMBP2, AARS, RAB7A, KIF1B
nucleic acid binding (GO:0003676)	1.44	10	YARS, KARS, VCP, DYNC1H1, EGR2, HSPB1, MARS, AARS, AIFM1, IGHMBP2
cation binding (GO:0043169)	1.4	9	PRPS1, KARS, EGR2, LRSAM1, TRIM2, IGHMBP2, AARS, MORC2, FGD4
metal ion binding (GO:0046872)	1.41	9	PRPS1, KARS, EGR2, LRSAM1, TRIM2, IGHMBP2, AARS, MORC2, FGD4
ligase activity (GO:0016874)	3.72	9	KARS, YARS, GARS, EGR2, LRSAM1, HARS, TRIM2, MARS, AARS
ion binding (GO:0043167)	1.36	9	PRPS1, KARS, EGR2, LRSAM1, TRIM2, IGHMBP2, AARS, MORC2, FGD4
protein dimerization activity (GO:0046983)	2.72	8	SBF2, PRPS1, GJB1, NEFL, MTMR2, GARS, NEFH, AIFM1
RNA binding (GO:0003723)	2.36	8	YARS, KARS, VCP, DYNC1H1, MARS, HSPB1, AARS, IGHMBP2
identical protein binding (GO:0042802)	2.63	8	SBF2, PRPS1, GJB1, VCP, NEFL, MTMR2, HSPB1, HSPB8
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	7	DNM2, VCP, DYNC1H1, MFN2, IGHMBP2, RAB7A, KIF1B
nucleoside-triphosphatase activity (GO:0017111)	3.09	7	DNM2, VCP, DYNC1H1, MFN2, IGHMBP2, RAB7A, KIF1B
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	7	DNM2, VCP, DYNC1H1, MFN2, IGHMBP2, RAB7A, KIF1B
pyrophosphatase activity (GO:0016462)	3.04	7	DNM2, VCP, DYNC1H1, MFN2, IGHMBP2, RAB7A, KIF1B
transferase activity (GO:0016740)	1.95	7	PRPS1, GDAP1, HK1, LRSAM1, TRIM2, HSPB8, PDK3
molecular function regulator (GO:0098772)	2.51	7	SBF2, VCP, PLEKHG5, NEFL, HSPB1, SBF1, FGD4
ligase activity, forming carbon-oxygen bonds (GO:0016875)	5.93	6	KARS, YARS, GARS, MARS, HARS, AARS
aminoacyl-tRNA ligase activity (GO:0004812)	5.93	6	KARS, YARS, GARS, MARS, HARS, AARS
protein domain specific binding (GO:0019904)	3.32	6	DNM2, TRPV4, VCP, NEFL, EGR2, LITAF
ligase activity, forming aminoacyl-tRNA and related compounds (GO:0016876)	5.93	6	KARS, YARS, GARS, MARS, HARS, AARS
cytoskeletal protein binding (GO:0008092)	3.02	6	DNM2, TRPV4, NDRG1, FGD4, NEFH, KIF1B
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	5	PLEKHG5, NEFL, FGD4, SBF2, SBF1
tubulin binding (GO:0015631)	4.1	5	NDRG1, DNM2, TRPV4, NEFH, KIF1B
tRNA binding (GO:0000049)	5.95	5	MARS, YARS, AARS, KARS, IGHMBP2
transition metal ion binding (GO:0046914)	2.48	5	AARS, MORC2, TRIM2, LRSAM1, IGHMBP2
microtubule binding (GO:0008017)	4.42	5	NDRG1, NEFH, TRPV4, DNM2, KIF1B
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	5	PLEKHG5, NEFL, FGD4, SBF2, SBF1
structural molecule activity (GO:0005198)	3.1	5	NEFL, MPZ, NEFH, JPH1, LMNA
macromolecular complex binding (GO:0044877)	2.61	5	DNM2, TRPV4, EGR2, VCP, IGHMBP2
zinc ion binding (GO:0008270)	2.66	5	AARS, MORC2, TRIM2, LRSAM1, IGHMBP2
signal transducer activity (GO:0004871)	2.28	4	PLEKHG5, LITAF, TRPV4, YARS
guanyl ribonucleotide binding (GO:0032561)	3.73	4	MFN2, PRPS1, RAB7A, DNM2
transporter activity (GO:0005215)	2.57	4	SURF1, TRPV4, COX6A1, GJB1
poly(A) RNA binding (GO:0044822)	2.69	4	DYNC1H1, HSPB1, YARS, VCP
kinase activity (GO:0016301)	2.93	4	PRPS1, PDK3, HK1, HSPB8
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	4	FIG4, MTMR2, AARS, SBF1
protein kinase binding (GO:0019901)	3.44	4	HSPB1, NEFH, TRPV4, DNM2
kinase binding (GO:0019900)	3.32	4	HSPB1, DNM2, TRPV4, NEFH
transmembrane transporter activity (GO:0022857)	2.82	4	SURF1, TRPV4, COX6A1, GJB1
ATPase activity (GO:0016887)	3.65	4	DYNC1H1, KIF1B, IGHMBP2, VCP
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	4	PRPS1, PDK3, HK1, HSPB8
receptor binding (GO:0005102)	2.43	4	MED25, YARS, VCP, DNM2
protein homodimerization activity (GO:0042803)	3.16	4	PRPS1, SBF2, MTMR2, GJB1
enzyme regulator activity (GO:0030234)	2.85	4	SBF2, HSPB1, VCP, SBF1
guanyl nucleotide binding (GO:0019001)	3.73	4	MFN2, PRPS1, RAB7A, DNM2
oxidoreductase activity (GO:0016491)	3.12	4	SURF1, AIFM1, DHTKD1, COX6A1
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	3	SURF1, TRPV4, COX6A1
phosphoric ester hydrolase activity (GO:0042578)	3.82	3	FIG4, MTMR2, SBF1
ubiquitin protein ligase binding (GO:0031625)	4.17	3	MFN2, VCP, EGR2
phosphatase activity (GO:0016791)	4.11	3	FIG4, MTMR2, SBF1
substrate-specific transporter activity (GO:0022892)	2.72	3	SURF1, TRPV4, COX6A1
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	3	SURF1, TRPV4, COX6A1
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	PDK3, HK1, HSPB8
transcription factor binding (GO:0008134)	3.46	3	MED25, IGHMBP2, EGR2
cation transmembrane transporter activity (GO:0008324)	3.32	3	SURF1, TRPV4, COX6A1
GTPase activity (GO:0003924)	4.31	3	MFN2, RAB7A, DNM2
ion transmembrane transporter activity (GO:0015075)	3.04	3	SURF1, TRPV4, COX6A1
small GTPase binding (GO:0031267)	4.13	3	NDRG1, RAB7A, FGD4
GTPase binding (GO:0051020)	4.05	3	NDRG1, RAB7A, FGD4
phosphatase binding (GO:0019902)	4.63	3	SBF2, LMNA, VCP
DNA binding (GO:0003677)	1.92	3	AIFM1, IGHMBP2, EGR2
protein complex binding (GO:0032403)	3.09	3	DNM2, TRPV4, VCP
ubiquitin-like protein ligase binding (GO:0044389)	4.15	3	MFN2, EGR2, VCP
electron carrier activity (GO:0009055)	4.97	3	SURF1, AIFM1, COX6A1
GTP binding (GO:0005525)	3.78	3	MFN2, RAB7A, DNM2
Rho guanyl-nucleotide exchange factor activity (GO:0005089)	5.37	2	PLEKHG5, FGD4
kinesin binding (GO:0019894)	6.24	2	NEFH, KIF1B
protein kinase C binding (GO:0005080)	5.83	2	HSPB1, TRPV4
phosphatase regulator activity (GO:0019208)	5.26	2	SBF2, SBF1
carbohydrate binding (GO:0030246)	4.17	2	PRPS1, HK1
structural constituent of cytoskeleton (GO:0005200)	5.12	2	NEFL, NEFH
phosphoprotein phosphatase activity (GO:0004721)	4.55	2	MTMR2, SBF1
G-protein coupled receptor binding (GO:0001664)	4.18	2	DNM2, YARS
amino acid binding (GO:0016597)	5.71	2	AARS, KARS
anion binding (GO:0043168)	4.17	2	AARS, KARS
coenzyme binding (GO:0050662)	4.53	2	DHTKD1, AIFM1
dynein binding (GO:0045502)	6.44	2	DYNC1H1, NEFH
actin binding (GO:0003779)	3.74	2	TRPV4, FGD4
GDP binding (GO:0019003)	5.81	2	RAB7A, PRPS1
protein kinase activity (GO:0004672)	3.27	2	PDK3, HSPB8
passive transmembrane transporter activity (GO:0022803)	3.6	2	TRPV4, GJB1
motor activity (GO:0003774)	4.81	2	DYNC1H1, KIF1B
microtubule motor activity (GO:0003777)	5.34	2	DYNC1H1, KIF1B
cytochrome-c oxidase activity (GO:0004129)	6.34	2	SURF1, COX6A1
ubiquitin-like protein transferase activity (GO:0019787)	3.69	2	LRSAM1, TRIM2
protein tyrosine/serine/threonine phosphatase activity (GO:0008138)	5.91	2	MTMR2, SBF1
WW domain binding (GO:0050699)	6.34	2	DNM2, LITAF
lipid binding (GO:0008289)	3.26	2	SBF2, VCP
Rab guanyl-nucleotide exchange factor activity (GO:0017112)	6.34	2	SBF2, SBF1
Ras GTPase binding (GO:0017016)	4.2	2	NDRG1, RAB7A
phosphatidylinositol bisphosphate phosphatase activity (GO:0034593)	6.44	2	FIG4, MTMR2
protein phosphatase binding (GO:0019903)	4.93	2	LMNA, VCP
cofactor binding (GO:0048037)	4.16	2	DHTKD1, AIFM1
ADP binding (GO:0043531)	6.24	2	PRPS1, VCP
channel activity (GO:0015267)	3.6	2	TRPV4, GJB1
ubiquitin-like protein binding (GO:0032182)	4.93	2	HSPB1, VCP
ubiquitin-protein transferase activity (GO:0004842)	3.73	2	LRSAM1, TRIM2
binding, bridging (GO:0060090)	4.57	2	NEFL, NEFH
phosphatidylinositol phosphate phosphatase activity (GO:0052866)	6.34	2	FIG4, MTMR2
protein binding, bridging (GO:0030674)	4.68	2	NEFL, NEFH
carboxylic acid binding (GO:0031406)	4.64	2	AARS, KARS
phosphatidylinositol monophosphate phosphatase activity (GO:0052744)	7.1	2	FIG4, MTMR2
phosphatidylinositol-3-phosphatase activity (GO:0004438)	7.1	2	FIG4, MTMR2
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	2	SURF1, COX6A1
ubiquitin binding (GO:0043130)	5.09	2	HSPB1, VCP
oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor (GO:0016676)	6.34	2	SURF1, COX6A1
heme-copper terminal oxidase activity (GO:0015002)	6.34	2	SURF1, COX6A1
oxidoreductase activity, acting on a heme group of donors (GO:0016675)	6.3	2	SURF1, COX6A1
protein heterodimerization activity (GO:0046982)	3.64	2	NEFL, NEFH
hydrogen ion transmembrane transporter activity (GO:0015078)	5.01	2	SURF1, COX6A1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
purine ribonucleoside triphosphate binding (GO:0035639)	-	2.22	0.002	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
enzyme binding (GO:0019899)	-	2.27	0.031	MFN2, DNM2, TRPV4, VCP, NDRG1, NEFL, SBF2, EGR2, HSPB1, RAB7A, NEFH, FGD4
purine nucleoside binding (GO:0001883)	-	2.22	0.002	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
nucleoside binding (GO:0001882)	-	2.21	0.002	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
anion binding (GO:0043168)	-	4.17	0.002	PRPS1, VCP, MFN2, MARS, EGR2, AARS, AIFM1, KIF1B, SBF2, TRPV4, HARS, MED25, HSPB1, LMNA, PDK3, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, DNM2, TRIM2, RAB7A, JPH1, KARS, NDRG1, NEFL, MTMR2, GARS, NAGLU, DHTKD1
tRNA binding (GO:0000049)	-	5.95	0.0	MARS, YARS, AARS, KARS, IGHMBP2
dynein binding (GO:0045502)	-	6.44	0.016	DYNC1H1, NEFH, VCP
nucleotide binding (GO:0000166)	-	1.96	0.012	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, AIFM1, PDK3, KIF1B, YARS
nucleoside phosphate binding (GO:1901265)	-	1.96	0.012	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, AIFM1, PDK3, KIF1B, YARS
ribonucleoside binding (GO:0032549)	-	2.22	0.002	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
purine nucleotide binding (GO:0017076)	-	2.19	0.003	PRPS1, VCP, MFN2, MARS, EGR2, AARS, AIFM1, KIF1B, DNM2, TRPV4, HARS, MED25, HSPB1, PDK3, IGHMBP2, YARS, DYNC1H1, HK1, TRIM2, KARS, NDRG1, GARS, NAGLU, RAB7A
ATP binding (GO:0005524)	-	2.43	0.012	PRPS1, KARS, VCP, DYNC1H1, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, PDK3, KIF1B, YARS
tubulin binding (GO:0015631)	-	4.1	0.022	DNM2, TRPV4, DYNC1H1, NEFL, NDRG1, HSPB1, RAB7A, NEFH, KIF1B
microtubule binding (GO:0008017)	-	4.42	0.001	DNM2, TRPV4, DYNC1H1, NEFL, NDRG1, HSPB1, RAB7A, NEFH, KIF1B
small molecule binding (GO:0036094)	-	1.89	0.012	DNM2, PRPS1, KARS, VCP, DYNC1H1, MFN2, HK1, GARS, HARS, MARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, AIFM1, DHTKD1, KIF1B, YARS
aminoacyl-tRNA ligase activity (GO:0004812)	-	5.93	0.0	KARS, YARS, GARS, MARS, HARS, AARS
ligase activity (GO:0016874)	-	3.72	0.001	YARS, KARS, VCP, GARS, EGR2, LRSAM1, HARS, TRIM2, MARS, AARS, KIF1B
ligase activity, forming carbon-oxygen bonds (GO:0016875)	-	5.93	0.0	KARS, YARS, GARS, MARS, HARS, AARS
ligase activity, forming aminoacyl-tRNA and related compounds (GO:0016876)	-	5.93	0.0	KARS, YARS, GARS, MARS, HARS, AARS
adenyl nucleotide binding (GO:0030554)	-	2.4	0.017	PRPS1, VCP, KARS, DYNC1H1, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, PDK3, KIF1B, YARS
carbohydrate derivative binding (GO:0097367)	-	2.03	0.016	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
phosphatidylinositol monophosphate phosphatase activity (GO:0052744)	-	7.1	0.043	FIG4, MTMR2
phosphatidylinositol-3-phosphatase activity (GO:0004438)	-	7.1	0.043	FIG4, MTMR2
phosphatase binding (GO:0019902)	-	4.63	0.016	SBF2, GJB1, VCP, DYNC1H1, MTMR2, DNM2, KARS
adenyl ribonucleotide binding (GO:0032559)	-	2.41	0.015	PRPS1, VCP, KARS, DYNC1H1, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, PDK3, KIF1B, YARS
protein binding (GO:0005515)	-	0.46	0.017	PRPS1, VCP, MFN2, LRSAM1, GARS, AIFM1, FGD4, SBF2, TRPV4, GJB1, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, YARS, DYNC1H1, HK1, DNM2, TRIM2, NEFH, SPG11, KARS, NDRG1, NEFL, MTMR2, FIG4, EGR2, SURF1, HSPB8, RAB7A, PMP22
purine ribonucleotide binding (GO:0032555)	-	2.2	0.033	PRPS1, VCP, MFN2, MARS, EGR2, AARS, AIFM1, KIF1B, DNM2, TRPV4, HARS, MED25, HSPB1, PDK3, IGHMBP2, YARS, DYNC1H1, HK1, TRIM2, KARS, NDRG1, GARS, NAGLU, RAB7A
purine ribonucleoside binding (GO:0032550)	-	2.22	0.002	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, HK1, GARS, MARS, HARS, IGHMBP2, AARS, TRPV4, RAB7A, PDK3, KIF1B, YARS
ribonucleotide binding (GO:0032553)	-	2.19	0.002	PRPS1, VCP, MFN2, MARS, EGR2, AARS, AIFM1, KIF1B, DNM2, TRPV4, HARS, MED25, HSPB1, PDK3, IGHMBP2, YARS, DYNC1H1, HK1, TRIM2, KARS, NDRG1, GARS, NAGLU, RAB7A

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	47	VCP, PRPS1, COX6A1, GJB1, PLEKHG5, MFN2, MARS, FIG4, NAGLU, AARS, MPZ, AIFM1, NEFH, FGD4, DNM2, TRPV4, GDAP1, HARS, PRX, MED25, HSPB1, KIF1B, SBF1, PDK3, LITAF, IGHMBP2, LMNA, YARS, DYNC1H1, HK1, SBF2, TRIM2, MORC2, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, NEFL, MTMR2, LRSAM1, EGR2, SURF1, RAB7A, PMP22, GARS
single-organism process (GO:0044699)	0.48	44	VCP, PRPS1, COX6A1, GJB1, PLEKHG5, MFN2, MARS, LRSAM1, EGR2, AARS, MPZ, AIFM1, NEFH, FGD4, DNM2, TRPV4, GDAP1, HARS, PRX, HSPB1, KIF1B, SBF1, PDK3, LITAF, GARS, LMNA, YARS, DYNC1H1, HK1, SBF2, MORC2, SPG11, DHTKD1, SH3TC2, KARS, JPH1, NDRG1, NEFL, MTMR2, FIG4, NAGLU, SURF1, RAB7A, PMP22
single-organism cellular process (GO:0044763)	0.65	42	EGR2, VCP, PRPS1, GDAP1, PLEKHG5, MFN2, MARS, FIG4, GARS, AARS, MPZ, AIFM1, NEFH, FGD4, SBF2, TRPV4, GJB1, HARS, PRX, HSPB1, KIF1B, LMNA, PDK3, LITAF, YARS, DYNC1H1, HK1, DNM2, MORC2, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, NEFL, MTMR2, COX6A1, NAGLU, SURF1, RAB7A, PMP22
biological regulation (GO:0065007)	0.39	32	VCP, PLEKHG5, MFN2, LRSAM1, AARS, MPZ, AIFM1, FGD4, DNM2, TRPV4, MED25, HSPB1, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, HK1, SBF2, TRIM2, NEFH, SH3TC2, JPH1, NDRG1, NEFL, MTMR2, FIG4, EGR2, HSPB8, RAB7A, PMP22
metabolic process (GO:0008152)	0.58	30	PRPS1, COX6A1, GDAP1, MARS, LRSAM1, EGR2, AARS, AIFM1, DNM2, TRPV4, VCP, HARS, MED25, SBF1, PDK3, LITAF, IGHMBP2, YARS, HK1, TRIM2, MORC2, DHTKD1, KARS, NEFL, MTMR2, FIG4, NAGLU, SURF1, RAB7A, GARS
regulation of biological process (GO:0050789)	0.45	29	VCP, PLEKHG5, MFN2, LRSAM1, AARS, MPZ, AIFM1, FGD4, DNM2, TRPV4, MED25, HSPB1, LMNA, PDK3, LITAF, IGHMBP2, YARS, TRIM2, NEFH, SH3TC2, JPH1, NDRG1, NEFL, MTMR2, FIG4, EGR2, HSPB8, RAB7A, PMP22
regulation of cellular process (GO:0050794)	0.5	29	VCP, PLEKHG5, MFN2, LRSAM1, AARS, MPZ, AIFM1, FGD4, DNM2, TRPV4, MED25, HSPB1, LMNA, PDK3, LITAF, IGHMBP2, YARS, TRIM2, NEFH, SH3TC2, JPH1, NDRG1, PMP22, MTMR2, FIG4, EGR2, HSPB8, RAB7A, NEFL
organic substance metabolic process (GO:0071704)	0.63	28	PRPS1, GDAP1, MARS, LRSAM1, GARS, AARS, AIFM1, DNM2, VCP, HARS, MED25, EGR2, SBF1, PDK3, LITAF, IGHMBP2, YARS, HK1, TRIM2, MORC2, DHTKD1, KARS, NEFL, MTMR2, FIG4, NAGLU, SURF1, RAB7A
cellular metabolic process (GO:0044237)	0.69	28	PRPS1, COX6A1, GDAP1, MARS, LRSAM1, EGR2, AARS, AIFM1, DNM2, VCP, HARS, MED25, SBF1, PDK3, LITAF, IGHMBP2, YARS, HK1, TRIM2, MORC2, DHTKD1, KARS, NEFL, MTMR2, FIG4, GARS, SURF1, RAB7A
primary metabolic process (GO:0044238)	0.69	25	PRPS1, VCP, MARS, LRSAM1, GARS, AARS, AIFM1, HARS, MED25, SBF1, PDK3, LITAF, IGHMBP2, YARS, HK1, TRIM2, MORC2, RAB7A, KARS, NEFL, MTMR2, FIG4, EGR2, SURF1, DHTKD1
cellular component organization (GO:0016043)	1.24	24	VCP, GDAP1, MFN2, LRSAM1, AIFM1, FGD4, SBF2, TRPV4, GJB1, HARS, LMNA, IGHMBP2, DYNC1H1, DNM2, NEFH, RAB7A, NDRG1, PMP22, MTMR2, FIG4, NAGLU, SURF1, SH3TC2, NEFL
cellular component organization or biogenesis (GO:0071840)	1.22	24	VCP, GDAP1, MFN2, LRSAM1, AIFM1, FGD4, SBF2, TRPV4, GJB1, HARS, LMNA, IGHMBP2, DYNC1H1, DNM2, NEFH, RAB7A, NDRG1, PMP22, MTMR2, FIG4, NAGLU, SURF1, SH3TC2, NEFL
single-organism metabolic process (GO:0044710)	1.63	21	DNM2, PRPS1, KARS, VCP, MTMR2, NEFL, HK1, FIG4, MARS, COX6A1, DHTKD1, SURF1, HARS, AARS, TRPV4, MORC2, PDK3, AIFM1, RAB7A, GARS, YARS
macromolecule metabolic process (GO:0043170)	0.83	21	DNM2, SBF1, YARS, KARS, VCP, AIFM1, NEFL, MTMR2, MED25, EGR2, IGHMBP2, LRSAM1, HARS, TRIM2, NAGLU, AARS, MARS, RAB7A, LITAF, PDK3, GARS
cellular macromolecule metabolic process (GO:0044260)	0.93	20	DNM2, YARS, SBF1, KARS, AIFM1, NEFL, VCP, MTMR2, MED25, EGR2, MARS, LRSAM1, HARS, TRIM2, GARS, AARS, RAB7A, LITAF, PDK3, IGHMBP2
transport (GO:0006810)	1.51	18	VCP, TRPV4, GDAP1, GJB1, DYNC1H1, NEFL, HK1, DNM2, EGR2, COX6A1, JPH1, LRSAM1, SURF1, LMNA, RAB7A, SPG11, MFN2, KIF1B
nitrogen compound metabolic process (GO:0006807)	1.13	18	VCP, PRPS1, KARS, GDAP1, AIFM1, GARS, HK1, SURF1, EGR2, MARS, MED25, HARS, NAGLU, AARS, DHTKD1, LITAF, IGHMBP2, YARS
localization (GO:0051179)	1.4	18	DNM2, TRPV4, GDAP1, GJB1, DYNC1H1, NEFL, HK1, VCP, EGR2, COX6A1, JPH1, LRSAM1, SURF1, LMNA, RAB7A, SPG11, MFN2, KIF1B
establishment of localization (GO:0051234)	1.48	18	DNM2, TRPV4, GDAP1, GJB1, DYNC1H1, MFN2, HK1, VCP, EGR2, COX6A1, JPH1, LRSAM1, SURF1, LMNA, RAB7A, SPG11, NEFL, KIF1B
positive regulation of biological process (GO:0048518)	1.2	17	DNM2, TRPV4, VCP, PLEKHG5, AIFM1, NEFL, MTMR2, MED25, EGR2, NDRG1, LRSAM1, HSPB1, LMNA, RAB7A, FIG4, LITAF, FGD4
developmental process (GO:0032502)	1.36	17	DNM2, PRPS1, JPH1, GJB1, SPG11, PMP22, MTMR2, NAGLU, LMNA, PRX, FIG4, EGR2, AARS, NEFH, LITAF, NEFL, MFN2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	17	VCP, PRPS1, KARS, GDAP1, AIFM1, GARS, HK1, SURF1, EGR2, MED25, HARS, MARS, AARS, DHTKD1, LITAF, IGHMBP2, YARS
positive regulation of cellular process (GO:0048522)	1.3	17	DNM2, TRPV4, VCP, PLEKHG5, AIFM1, NEFL, MTMR2, MED25, EGR2, NDRG1, LRSAM1, HSPB1, LMNA, RAB7A, FIG4, LITAF, FGD4
nucleobase-containing compound metabolic process (GO:0006139)	1.35	16	PRPS1, VCP, KARS, AIFM1, GARS, HK1, SURF1, EGR2, MED25, HARS, MARS, AARS, DHTKD1, LITAF, IGHMBP2, YARS
cellular protein metabolic process (GO:0044267)	1.63	16	SBF1, YARS, KARS, VCP, NEFL, MTMR2, GARS, EGR2, LRSAM1, HARS, TRIM2, MARS, AARS, RAB7A, PDK3, IGHMBP2
protein metabolic process (GO:0019538)	1.45	16	SBF1, YARS, KARS, VCP, NEFL, MTMR2, GARS, EGR2, LRSAM1, HARS, TRIM2, MARS, AARS, RAB7A, PDK3, IGHMBP2
response to stimulus (GO:0050896)	1.22	16	DNM2, TRPV4, VCP, GDAP1, NDRG1, AIFM1, NEFL, EGR2, LMNA, HSPB1, AARS, NEFH, PDK3, LITAF, MFN2, IGHMBP2
cellular aromatic compound metabolic process (GO:0006725)	1.3	16	PRPS1, KARS, VCP, AIFM1, GARS, HK1, SURF1, EGR2, MED25, HARS, MARS, AARS, DHTKD1, LITAF, IGHMBP2, YARS
organic cyclic compound metabolic process (GO:1901360)	1.26	16	PRPS1, VCP, KARS, AIFM1, GARS, HK1, SURF1, EGR2, MED25, HARS, MARS, AARS, DHTKD1, LITAF, IGHMBP2, YARS
negative regulation of biological process (GO:0048519)	1.33	16	DNM2, TRPV4, LMNA, NDRG1, NEFL, MTMR2, MED25, FIG4, LRSAM1, HSPB1, AARS, RAB7A, MPZ, LITAF, PMP22, MFN2
negative regulation of cellular process (GO:0048523)	1.41	16	DNM2, TRPV4, LMNA, NDRG1, RAB7A, NEFL, MTMR2, MED25, FIG4, LRSAM1, HSPB1, AARS, MPZ, LITAF, PMP22, MFN2
heterocycle metabolic process (GO:0046483)	1.31	16	PRPS1, KARS, VCP, AIFM1, GARS, HK1, SURF1, EGR2, MED25, HARS, MARS, AARS, DHTKD1, LITAF, IGHMBP2, YARS
organelle organization (GO:0006996)	2.02	15	MFN2, TRPV4, GDAP1, DYNC1H1, NEFL, FIG4, NAGLU, LRSAM1, HARS, IGHMBP2, LMNA, RAB7A, AIFM1, NEFH, FGD4
organic substance biosynthetic process (GO:1901576)	1.34	15	PRPS1, VCP, KARS, MTMR2, FIG4, EGR2, MARS, MED25, HARS, SURF1, GARS, AARS, LITAF, IGHMBP2, YARS
single-organism developmental process (GO:0044767)	1.49	15	DNM2, PRPS1, LMNA, JPH1, SPG11, NEFL, MTMR2, NAGLU, PRX, FIG4, EGR2, AARS, NEFH, LITAF, MFN2
cellular biosynthetic process (GO:0044249)	1.37	15	PRPS1, VCP, KARS, MTMR2, FIG4, EGR2, MARS, MED25, HARS, SURF1, GARS, AARS, LITAF, IGHMBP2, YARS
biosynthetic process (GO:0009058)	1.32	15	PRPS1, VCP, KARS, GARS, MTMR2, FIG4, EGR2, MED25, HARS, SURF1, MARS, AARS, LITAF, IGHMBP2, YARS
response to chemical (GO:0042221)	1.98	15	DNM2, TRPV4, VCP, GDAP1, NDRG1, AIFM1, NEFL, EGR2, LMNA, HSPB1, AARS, NEFH, PDK3, LITAF, MFN2
cellular response to stimulus (GO:0051716)	1.97	14	DNM2, TRPV4, LMNA, VCP, NDRG1, AIFM1, NEFL, EGR2, HSPB1, AARS, NEFH, LITAF, PDK3, IGHMBP2
cellular component assembly (GO:0022607)	2.14	14	SBF2, TRPV4, GJB1, VCP, DYNC1H1, NEFL, MTMR2, SURF1, FIG4, IGHMBP2, NEFH, AIFM1, PMP22, FGD4
organonitrogen compound metabolic process (GO:1901564)	2.32	14	VCP, PRPS1, KARS, GDAP1, HK1, GARS, NAGLU, SURF1, HARS, MARS, AARS, DHTKD1, IGHMBP2, YARS
anatomical structure development (GO:0048856)	1.58	14	DNM2, PRPS1, JPH1, GJB1, PMP22, MTMR2, NAGLU, LMNA, PRX, FIG4, EGR2, AARS, NEFH, NEFL
regulation of response to stimulus (GO:0048583)	1.54	14	DNM2, TRPV4, LMNA, JPH1, PLEKHG5, MFN2, MTMR2, LRSAM1, HSPB1, HSPB8, SH3TC2, LITAF, RAB7A, FGD4
signal transduction (GO:0007165)	1.28	14	DNM2, TRPV4, YARS, VCP, PLEKHG5, AIFM1, NEFL, LMNA, NDRG1, HSPB1, AARS, RAB7A, LITAF, PDK3
regulation of biological quality (GO:0065008)	1.68	14	TRPV4, JPH1, VCP, MTMR2, NEFL, HK1, EGR2, HSPB1, AARS, RAB7A, PDK3, AIFM1, MFN2, FGD4
small molecule metabolic process (GO:0044281)	2.38	14	PRPS1, VCP, KARS, MTMR2, HK1, GARS, SURF1, HARS, MARS, AARS, MORC2, PDK3, DHTKD1, YARS
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	13	PRPS1, VCP, KARS, GARS, SURF1, EGR2, MED25, HARS, MARS, AARS, LITAF, IGHMBP2, YARS
regulation of metabolic process (GO:0019222)	1.02	13	DNM2, TRPV4, VCP, AIFM1, MTMR2, EGR2, MED25, HSPB1, AARS, RAB7A, LITAF, PDK3, IGHMBP2
regulation of cellular component organization (GO:0051128)	2.01	13	DNM2, TRPV4, VCP, NEFL, MTMR2, MED25, FIG4, LRSAM1, LMNA, RAB7A, AIFM1, PMP22, FGD4
regulation of signaling (GO:0023051)	1.72	13	DNM2, TRPV4, JPH1, PLEKHG5, MFN2, MTMR2, EGR2, HSPB1, LMNA, SH3TC2, LITAF, RAB7A, FGD4
regulation of cell communication (GO:0010646)	1.73	13	DNM2, TRPV4, JPH1, PLEKHG5, MFN2, MTMR2, EGR2, HSPB1, LMNA, SH3TC2, LITAF, RAB7A, FGD4
response to organic substance (GO:0010033)	2.2	13	DNM2, TRPV4, VCP, GDAP1, AIFM1, NEFL, EGR2, HSPB1, AARS, NEFH, PDK3, LITAF, MFN2
single-organism localization (GO:1902578)	2.09	13	DNM2, TRPV4, JPH1, GJB1, DYNC1H1, NEFL, HK1, SURF1, COX6A1, LRSAM1, LMNA, SPG11, KIF1B
regulation of primary metabolic process (GO:0080090)	1.08	12	DNM2, TRPV4, VCP, AIFM1, EGR2, MED25, HSPB1, AARS, RAB7A, LITAF, PDK3, IGHMBP2
regulation of signal transduction (GO:0009966)	1.84	12	DNM2, TRPV4, JPH1, PLEKHG5, MFN2, MTMR2, HSPB1, LMNA, RAB7A, LITAF, SH3TC2, FGD4
establishment of localization in cell (GO:0051649)	2.47	12	DNM2, VCP, GDAP1, DYNC1H1, NEFL, EGR2, JPH1, LMNA, RAB7A, SPG11, MFN2, KIF1B
regulation of cellular metabolic process (GO:0031323)	1.07	12	DNM2, TRPV4, VCP, AIFM1, MTMR2, EGR2, MED25, HSPB1, AARS, PDK3, LITAF, IGHMBP2
single-organism transport (GO:0044765)	2.18	12	DNM2, TRPV4, GJB1, JPH1, NEFL, HK1, SURF1, COX6A1, LRSAM1, LMNA, SPG11, KIF1B
regulation of programmed cell death (GO:0043067)	2.49	12	DNM2, LMNA, VCP, PLEKHG5, NEFL, NDRG1, HSPB1, AARS, TRIM2, MPZ, AIFM1, FGD4
nucleic acid metabolic process (GO:0090304)	1.46	12	YARS, KARS, VCP, AIFM1, GARS, EGR2, MED25, HARS, MARS, AARS, LITAF, IGHMBP2
regulation of macromolecule metabolic process (GO:0060255)	1.08	12	DNM2, TRPV4, VCP, AIFM1, MTMR2, EGR2, MED25, HSPB1, AARS, RAB7A, LITAF, IGHMBP2
phosphate-containing compound metabolic process (GO:0006796)	2.16	12	PRPS1, KARS, VCP, MTMR2, NEFL, HK1, SURF1, GARS, FIG4, SBF1, DHTKD1, PDK3
response to stress (GO:0006950)	1.8	12	DNM2, TRPV4, LMNA, VCP, NDRG1, MFN2, HSPB1, AARS, NEFH, AIFM1, NEFL, IGHMBP2
phosphorus metabolic process (GO:0006793)	2.15	12	PRPS1, VCP, KARS, MTMR2, NEFL, HK1, SURF1, GARS, FIG4, SBF1, PDK3, DHTKD1
regulation of cell death (GO:0010941)	2.43	12	DNM2, LMNA, VCP, PLEKHG5, NEFL, NDRG1, HSPB1, AARS, TRIM2, MPZ, AIFM1, FGD4
regulation of apoptotic process (GO:0042981)	2.5	12	DNM2, LMNA, VCP, PLEKHG5, NEFL, NDRG1, HSPB1, AARS, TRIM2, MPZ, AIFM1, FGD4
cellular developmental process (GO:0048869)	1.82	11	DNM2, NEFL, PMP22, MTMR2, NAGLU, FIG4, EGR2, LMNA, DHTKD1, AIFM1, NEFH
macromolecule biosynthetic process (GO:0009059)	1.61	11	YARS, KARS, VCP, GARS, EGR2, MED25, HARS, MARS, AARS, LITAF, IGHMBP2
cellular macromolecule biosynthetic process (GO:0034645)	1.66	11	YARS, KARS, VCP, GARS, EGR2, MED25, HARS, MARS, AARS, LITAF, IGHMBP2
organic substance transport (GO:0071702)	2.15	11	VCP, TRPV4, GDAP1, GJB1, MFN2, HK1, DNM2, EGR2, LRSAM1, LMNA, RAB7A
regulation of molecular function (GO:0065009)	1.78	11	SBF2, JPH1, VCP, PLEKHG5, NEFL, DNM2, MED25, HSPB1, SBF1, AIFM1, FGD4
regulation of localization (GO:0032879)	1.94	11	DNM2, TRPV4, JPH1, MTMR2, LRSAM1, HSPB1, LMNA, SH3TC2, LITAF, RAB7A, NEFH
cellular localization (GO:0051641)	2.32	11	DNM2, VCP, GDAP1, DYNC1H1, NEFL, EGR2, LMNA, RAB7A, SPG11, MFN2, KIF1B
response to oxygen-containing compound (GO:1901700)	2.57	10	DNM2, TRPV4, GDAP1, AIFM1, NEFL, EGR2, AARS, NEFH, LITAF, PDK3
RNA metabolic process (GO:0016070)	1.59	10	YARS, KARS, GARS, EGR2, MED25, HARS, MARS, AARS, LITAF, IGHMBP2
regulation of multicellular organismal process (GO:0051239)	1.87	10	DNM2, TRPV4, PMP22, MTMR2, EGR2, FIG4, HSPB1, LMNA, LITAF, NEFL
intracellular transport (GO:0046907)	2.67	10	GDAP1, VCP, DYNC1H1, NEFL, EGR2, LMNA, RAB7A, SPG11, MFN2, KIF1B
organic acid metabolic process (GO:0006082)	3.01	10	PRPS1, YARS, KARS, HK1, GARS, MARS, HARS, AARS, MORC2, DHTKD1
macromolecular complex subunit organization (GO:0043933)	2.14	10	SBF2, TRPV4, GJB1, VCP, DYNC1H1, NEFL, MTMR2, SURF1, AIFM1, IGHMBP2
regulation of cellular biosynthetic process (GO:0031326)	1.38	10	DNM2, TRPV4, VCP, EGR2, MED25, HSPB1, AARS, PDK3, LITAF, IGHMBP2
regulation of biosynthetic process (GO:0009889)	1.37	10	DNM2, TRPV4, VCP, EGR2, MED25, HSPB1, AARS, PDK3, LITAF, IGHMBP2
macromolecular complex assembly (GO:0065003)	2.55	10	SBF2, TRPV4, GJB1, VCP, DYNC1H1, NEFL, MTMR2, SURF1, AIFM1, IGHMBP2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	10	DNM2, TRPV4, VCP, AIFM1, EGR2, MED25, HSPB1, AARS, LITAF, IGHMBP2
cellular response to chemical stimulus (GO:0070887)	2.57	10	DNM2, LMNA, NDRG1, AIFM1, EGR2, HSPB1, AARS, NEFH, LITAF, PDK3
cellular response to stress (GO:0033554)	2.51	10	DNM2, TRPV4, LMNA, VCP, NDRG1, NEFL, AARS, NEFH, AIFM1, IGHMBP2
protein complex assembly (GO:0006461)	2.78	9	SBF2, TRPV4, GJB1, VCP, NEFL, MTMR2, SURF1, AIFM1, IGHMBP2
protein complex subunit organization (GO:0071822)	2.6	9	SBF2, TRPV4, GJB1, VCP, NEFL, MTMR2, SURF1, AIFM1, IGHMBP2
organonitrogen compound biosynthetic process (GO:1901566)	2.85	9	PRPS1, YARS, KARS, GARS, MARS, SURF1, HARS, AARS, IGHMBP2
regulation of developmental process (GO:0050793)	2.1	9	DNM2, TRPV4, PMP22, MTMR2, FIG4, HSPB1, LMNA, NEFL, FGD4
regulation of transport (GO:0051049)	2.24	9	DNM2, TRPV4, JPH1, MTMR2, LRSAM1, SH3TC2, LITAF, RAB7A, NEFH
regulation of catalytic activity (GO:0050790)	1.97	9	SBF2, VCP, PLEKHG5, NEFL, DNM2, HSPB1, SBF1, AIFM1, FGD4
macromolecule modification (GO:0043412)	1.73	9	AARS, VCP, NEFL, MTMR2, EGR2, LRSAM1, TRIM2, SBF1, PDK3
carboxylic acid metabolic process (GO:0019752)	3.12	9	YARS, KARS, HK1, GARS, MARS, HARS, AARS, DHTKD1, MORC2
establishment of protein localization (GO:0045184)	2.53	9	DNM2, GDAP1, VCP, MFN2, HK1, EGR2, LRSAM1, LMNA, RAB7A
organophosphate metabolic process (GO:0019637)	3.04	9	PRPS1, KARS, VCP, MTMR2, HK1, SURF1, GARS, FIG4, DHTKD1
single-organism organelle organization (GO:1902589)	2.68	9	TRPV4, GDAP1, DYNC1H1, MFN2, LMNA, RAB7A, NEFH, NEFL, FGD4
positive regulation of molecular function (GO:0044093)	2.23	9	SBF2, VCP, PLEKHG5, NEFL, DNM2, MED25, SBF1, AIFM1, FGD4
oxoacid metabolic process (GO:0043436)	3.12	9	YARS, KARS, HK1, GARS, MARS, HARS, AARS, DHTKD1, MORC2
aromatic compound biosynthetic process (GO:0019438)	1.7	9	PRPS1, KARS, VCP, SURF1, EGR2, MED25, GARS, LITAF, IGHMBP2
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	9	PRPS1, KARS, VCP, SURF1, EGR2, MED25, GARS, LITAF, IGHMBP2
organic cyclic compound biosynthetic process (GO:1901362)	1.66	9	PRPS1, KARS, VCP, SURF1, EGR2, MED25, GARS, LITAF, IGHMBP2
heterocycle biosynthetic process (GO:0018130)	1.7	9	PRPS1, KARS, VCP, SURF1, EGR2, MED25, GARS, LITAF, IGHMBP2
regulation of hydrolase activity (GO:0051336)	2.53	8	SBF2, VCP, PLEKHG5, NEFL, DNM2, SBF1, AIFM1, FGD4
organic substance catabolic process (GO:1901575)	2.45	8	VCP, MTMR2, HK1, NAGLU, LRSAM1, DHTKD1, AIFM1, RAB7A
macromolecule localization (GO:0033036)	2.34	8	DNM2, GDAP1, VCP, MFN2, EGR2, LRSAM1, LMNA, RAB7A
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	8	DNM2, TRPV4, VCP, EGR2, MED25, HSPB1, RAB7A, AIFM1
positive regulation of hydrolase activity (GO:0051345)	2.91	8	SBF2, VCP, PLEKHG5, NEFL, DNM2, SBF1, AIFM1, FGD4
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	8	DNM2, TRPV4, EGR2, MED25, HSPB1, AARS, LITAF, IGHMBP2
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	8	DNM2, TRPV4, VCP, AIFM1, EGR2, MED25, LITAF, IGHMBP2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	8	DNM2, TRPV4, EGR2, MED25, HSPB1, AARS, LITAF, IGHMBP2
cellular protein modification process (GO:0006464)	1.79	8	VCP, NEFL, MTMR2, EGR2, LRSAM1, TRIM2, SBF1, PDK3
protein localization (GO:0008104)	2.36	8	DNM2, GDAP1, VCP, MFN2, EGR2, LRSAM1, LMNA, RAB7A
cellular response to organic substance (GO:0071310)	2.78	8	DNM2, AIFM1, EGR2, HSPB1, AARS, NEFH, LITAF, PDK3
protein modification process (GO:0036211)	1.79	8	VCP, NEFL, MTMR2, EGR2, LRSAM1, TRIM2, SBF1, PDK3
regulation of multicellular organismal development (GO:2000026)	2.31	8	DNM2, TRPV4, PMP22, MTMR2, FIG4, HSPB1, LMNA, NEFL
cellular amide metabolic process (GO:0043603)	3.23	8	GDAP1, YARS, GARS, MARS, HARS, AARS, KARS, IGHMBP2
protein transport (GO:0015031)	2.62	8	DNM2, GDAP1, VCP, MFN2, EGR2, LRSAM1, LMNA, RAB7A
peptide metabolic process (GO:0006518)	3.44	8	GDAP1, YARS, GARS, MARS, HARS, AARS, KARS, IGHMBP2
regulation of intracellular signal transduction (GO:1902531)	2.31	8	DNM2, TRPV4, JPH1, PLEKHG5, MFN2, HSPB1, LITAF, FGD4
catabolic process (GO:0009056)	2.38	8	VCP, MTMR2, HK1, NAGLU, LRSAM1, DHTKD1, AIFM1, RAB7A
regulation of gene expression (GO:0010468)	1.37	8	DNM2, TRPV4, EGR2, MED25, HSPB1, AARS, LITAF, IGHMBP2
positive regulation of catalytic activity (GO:0043085)	2.4	8	SBF2, VCP, PLEKHG5, NEFL, DNM2, SBF1, AIFM1, FGD4
positive regulation of metabolic process (GO:0009893)	1.74	8	DNM2, TRPV4, VCP, EGR2, MED25, HSPB1, RAB7A, AIFM1
negative regulation of response to stimulus (GO:0048585)	2.52	7	DNM2, MFN2, MTMR2, HSPB1, LMNA, RAB7A, LITAF
response to endogenous stimulus (GO:0009719)	2.79	7	DNM2, TRPV4, NEFL, EGR2, AARS, NEFH, AIFM1
microtubule-based process (GO:0007017)	3.54	7	TRPV4, DYNC1H1, NEFL, LMNA, NEFH, SPG11, KIF1B
negative regulation of signal transduction (GO:0009968)	2.75	7	DNM2, MFN2, MTMR2, HSPB1, LMNA, RAB7A, LITAF
membrane organization (GO:0061024)	3.04	7	GDAP1, NDRG1, MFN2, LRSAM1, LMNA, SH3TC2, RAB7A
response to organonitrogen compound (GO:0010243)	3.2	7	DNM2, TRPV4, NEFL, EGR2, AARS, NEFH, AIFM1
peptide biosynthetic process (GO:0043043)	3.73	7	KARS, YARS, GARS, MARS, HARS, AARS, IGHMBP2
positive regulation of cellular metabolic process (GO:0031325)	1.81	7	DNM2, TRPV4, VCP, EGR2, MED25, HSPB1, AIFM1
movement of cell or subcellular component (GO:0006928)	2.61	7	PLEKHG5, NEFL, EGR2, DYNC1H1, HSPB1, SPG11, KIF1B
homeostatic process (GO:0042592)	2.61	7	TRPV4, JPH1, HK1, HSPB1, RAB7A, AIFM1, PDK3
negative regulation of signaling (GO:0023057)	2.65	7	DNM2, MFN2, MTMR2, HSPB1, LMNA, RAB7A, LITAF
translation (GO:0006412)	3.79	7	KARS, YARS, GARS, MARS, HARS, AARS, IGHMBP2
animal organ development (GO:0048513)	2.53	7	PRPS1, LMNA, JPH1, NEFL, EGR2, AARS, NEFH
nucleotide metabolic process (GO:0009117)	3.73	7	PRPS1, KARS, VCP, HK1, GARS, SURF1, DHTKD1
negative regulation of cell communication (GO:0010648)	2.66	7	DNM2, MFN2, MTMR2, HSPB1, LMNA, RAB7A, LITAF
nucleoside phosphate metabolic process (GO:0006753)	3.71	7	PRPS1, KARS, VCP, HK1, GARS, SURF1, DHTKD1
positive regulation of cellular component organization (GO:0051130)	2.68	7	DNM2, TRPV4, VCP, NEFL, FIG4, LRSAM1, MED25
response to nitrogen compound (GO:1901698)	3.12	7	DNM2, TRPV4, NEFL, EGR2, AARS, NEFH, AIFM1
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	7	PRPS1, KARS, VCP, HK1, GARS, SURF1, DHTKD1
amide biosynthetic process (GO:0043604)	3.6	7	KARS, YARS, GARS, MARS, HARS, AARS, IGHMBP2
regulation of cellular localization (GO:0060341)	3.03	6	JPH1, MTMR2, LMNA, SH3TC2, LITAF, NEFH
cell projection organization (GO:0030030)	3.14	6	DNM2, PMP22, MTMR2, NEFH, NEFL, FGD4
phosphorylation (GO:0016310)	2.63	6	PRPS1, NEFL, HK1, SURF1, PDK3, DHTKD1
negative regulation of cellular component organization (GO:0051129)	3.35	6	DNM2, TRPV4, PMP22, MTMR2, LRSAM1, LMNA
ncRNA metabolic process (GO:0034660)	3.44	6	KARS, YARS, GARS, MARS, HARS, AARS
cell death (GO:0008219)	3.05	6	YARS, LITAF, PMP22, AIFM1, MFN2, KIF1B
single-organism biosynthetic process (GO:0044711)	2.8	6	PRPS1, KARS, MTMR2, SURF1, GARS, FIG4
tRNA metabolic process (GO:0006399)	4.52	6	KARS, YARS, GARS, MARS, HARS, AARS
response to lipid (GO:0033993)	3.11	6	GDAP1, LITAF, NEFL, PDK3, AIFM1, NEFH
intracellular protein transport (GO:0006886)	3.2	6	GDAP1, VCP, MFN2, EGR2, LMNA, RAB7A
cellular amino acid metabolic process (GO:0006520)	4.22	6	KARS, YARS, GARS, MARS, HARS, AARS
regulation of protein metabolic process (GO:0051246)	1.93	6	TRPV4, VCP, HSPB1, AARS, RAB7A, AIFM1
regulation of nervous system development (GO:0051960)	3.1	6	DNM2, TRPV4, PMP22, MTMR2, FIG4, NEFL
cellular homeostasis (GO:0019725)	3.23	6	TRPV4, JPH1, HK1, RAB7A, AIFM1, PDK3
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	6	DNM2, TRPV4, EGR2, MED25, LITAF, IGHMBP2
regulation of cell differentiation (GO:0045595)	2.42	6	DNM2, TRPV4, PMP22, FIG4, LMNA, NEFL
single-organism membrane organization (GO:0044802)	3.19	6	GDAP1, NDRG1, MFN2, LMNA, RAB7A, SH3TC2
regulation of RNA biosynthetic process (GO:2001141)	1.55	6	DNM2, TRPV4, EGR2, MED25, LITAF, IGHMBP2
cell communication (GO:0007154)	3.04	6	GJB1, AIFM1, PMP22, MPZ, SPG11, KIF1B
organophosphate biosynthetic process (GO:0090407)	3.67	6	PRPS1, KARS, MTMR2, SURF1, GARS, FIG4
organelle localization (GO:0051640)	3.94	6	DNM2, DYNC1H1, MFN2, SPG11, NEFL, KIF1B
cytoskeleton organization (GO:0007010)	3.22	6	TRPV4, DYNC1H1, NEFL, LMNA, NEFH, FGD4
vesicle-mediated transport (GO:0016192)	2.72	6	DNM2, VCP, DYNC1H1, LRSAM1, RAB7A, SPG11
carbohydrate derivative metabolic process (GO:1901135)	3.07	6	PRPS1, VCP, HK1, NAGLU, SURF1, DHTKD1
regulation of RNA metabolic process (GO:0051252)	1.52	6	DNM2, TRPV4, EGR2, MED25, LITAF, IGHMBP2
regulation of transcription, DNA-templated (GO:0006355)	1.56	6	DNM2, TRPV4, EGR2, MED25, LITAF, IGHMBP2
amino acid activation (GO:0043038)	5.76	6	KARS, YARS, GARS, MARS, HARS, AARS
tRNA aminoacylation (GO:0043039)	5.76	6	KARS, YARS, GARS, MARS, HARS, AARS
tRNA aminoacylation for protein translation (GO:0006418)	5.82	6	KARS, YARS, GARS, MARS, HARS, AARS
single-organism cellular localization (GO:1902580)	3.16	6	DNM2, DYNC1H1, NEFL, LMNA, SPG11, KIF1B
purine nucleoside metabolic process (GO:0042278)	4.32	5	PRPS1, SURF1, HK1, DHTKD1, VCP
regulation of organelle organization (GO:0033043)	2.72	5	RAB7A, TRPV4, LRSAM1, LMNA, DNM2
cellular macromolecular complex assembly (GO:0034622)	3.18	5	DYNC1H1, AIFM1, SURF1, TRPV4, NEFL
cellular chemical homeostasis (GO:0055082)	3.4	5	HK1, RAB7A, TRPV4, PDK3, JPH1
purine ribonucleoside monophosphate metabolic process (GO:0009167)	4.7	5	PRPS1, DHTKD1, HK1, SURF1, VCP
microtubule cytoskeleton organization (GO:0000226)	4.13	5	DYNC1H1, NEFL, TRPV4, NEFH, LMNA
negative regulation of cell death (GO:0060548)	2.95	5	NEFL, MPZ, HSPB1, AARS, LMNA
ribonucleoside monophosphate metabolic process (GO:0009161)	4.62	5	PRPS1, DHTKD1, HK1, SURF1, VCP
positive regulation of cell death (GO:0010942)	3.32	5	PLEKHG5, DNM2, AIFM1, FGD4, VCP
nucleoside monophosphate metabolic process (GO:0009123)	4.54	5	PRPS1, DHTKD1, HK1, SURF1, VCP
intracellular signal transduction (GO:0035556)	2.39	5	NDRG1, HSPB1, RAB7A, AIFM1, NEFL
establishment of organelle localization (GO:0051656)	4.15	5	DYNC1H1, NEFL, SPG11, DNM2, KIF1B
regulation of GTPase activity (GO:0043087)	3.21	5	PLEKHG5, NEFL, FGD4, SBF2, SBF1
ribonucleotide metabolic process (GO:0009259)	4.11	5	PRPS1, SURF1, HK1, DHTKD1, VCP
ensheathment of neurons (GO:0007272)	5.48	5	PRX, SH3TC2, SBF2, PMP22, EGR2
single-organism catabolic process (GO:0044712)	3.21	5	MTMR2, DHTKD1, HK1, RAB7A, VCP
regulation of neurogenesis (GO:0050767)	3.21	5	NEFL, TRPV4, PMP22, FIG4, DNM2
response to inorganic substance (GO:0010035)	3.56	5	NDRG1, NEFH, AIFM1, NEFL, DNM2
positive regulation of GTPase activity (GO:0043547)	3.28	5	PLEKHG5, NEFL, SBF2, FGD4, SBF1
regulation of cellular component biogenesis (GO:0044087)	3.08	5	RAB7A, LRSAM1, MED25, VCP, DNM2
anatomical structure morphogenesis (GO:0009653)	2.53	5	MFN2, NEFL, NEFH, DNM2, NAGLU
purine nucleoside monophosphate metabolic process (GO:0009126)	4.69	5	PRPS1, SURF1, HK1, DHTKD1, VCP
positive regulation of multicellular organismal process (GO:0051240)	2.49	5	HSPB1, NEFL, TRPV4, FIG4, LMNA
negative regulation of multicellular organismal process (GO:0051241)	2.84	5	TRPV4, PMP22, MTMR2, FIG4, LMNA
positive regulation of apoptotic process (GO:0043065)	3.38	5	PLEKHG5, DNM2, AIFM1, FGD4, VCP
positive regulation of protein metabolic process (GO:0051247)	2.43	5	AIFM1, RAB7A, HSPB1, TRPV4, VCP
regulation of cell development (GO:0060284)	3.01	5	NEFL, TRPV4, PMP22, FIG4, DNM2
regulation of cell projection organization (GO:0031344)	3.38	5	NEFL, TRPV4, PMP22, FIG4, DNM2
interspecies interaction between organisms (GO:0044419)	3.08	5	RAB7A, LRSAM1, HSPB1, KARS, VCP
regulation of neuron differentiation (GO:0045664)	3.39	5	NEFL, TRPV4, PMP22, FIG4, DNM2
negative regulation of apoptotic process (GO:0043066)	3.04	5	NEFL, MPZ, HSPB1, AARS, LMNA
cation transport (GO:0006812)	3.11	5	SURF1, TRPV4, COX6A1, JPH1, DNM2
response to abiotic stimulus (GO:0009628)	2.8	5	NDRG1, AIFM1, DNM2, TRPV4, LMNA
signaling (GO:0023052)	3.25	5	KIF1B, PMP22, SPG11, MPZ, GJB1
negative regulation of programmed cell death (GO:0043069)	3.02	5	NEFL, MPZ, HSPB1, AARS, LMNA
positive regulation of programmed cell death (GO:0043068)	3.38	5	PLEKHG5, DNM2, AIFM1, FGD4, VCP
protein oligomerization (GO:0051259)	3.71	5	SBF2, MTMR2, GJB1, VCP, IGHMBP2
multicellular organismal process (GO:0032501)	1.45	5	NEFL, MFN2, TRPV4, AARS, EGR2
cellular response to oxygen-containing compound (GO:1901701)	3.22	5	LITAF, PDK3, AIFM1, NEFH, DNM2
establishment of protein localization to organelle (GO:0072594)	3.92	5	MFN2, HK1, RAB7A, LMNA, GDAP1
ion transport (GO:0006811)	2.66	5	SURF1, TRPV4, COX6A1, JPH1, DNM2
apoptotic process (GO:0006915)	3.14	5	AIFM1, MFN2, LITAF, KIF1B, YARS
purine ribonucleotide metabolic process (GO:0009150)	4.16	5	PRPS1, DHTKD1, HK1, SURF1, VCP
purine-containing compound metabolic process (GO:0072521)	4.0	5	PRPS1, DHTKD1, HK1, SURF1, VCP
programmed cell death (GO:0012501)	3.1	5	AIFM1, MFN2, LITAF, KIF1B, YARS
multi-organism cellular process (GO:0044764)	3.14	5	RAB7A, LRSAM1, HSPB1, KARS, VCP
axon ensheathment (GO:0008366)	5.48	5	PRX, SH3TC2, SBF2, PMP22, EGR2
regulation of neuron projection development (GO:0010975)	3.69	5	PMP22, FIG4, TRPV4, NEFL, DNM2
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	5	RAB7A, LRSAM1, HSPB1, KARS, VCP
single-organism carbohydrate metabolic process (GO:0044723)	3.42	5	MTMR2, DHTKD1, HK1, PDK3, VCP
ribonucleoside metabolic process (GO:0009119)	4.21	5	PRPS1, SURF1, HK1, DHTKD1, VCP
purine ribonucleoside metabolic process (GO:0046128)	4.33	5	PRPS1, DHTKD1, HK1, SURF1, VCP
positive regulation of biosynthetic process (GO:0009891)	2.29	5	DNM2, HSPB1, EGR2, VCP, MED25
macromolecule catabolic process (GO:0009057)	3.0	5	RAB7A, LRSAM1, AIFM1, NAGLU, VCP
oxidation-reduction process (GO:0055114)	2.91	5	AIFM1, DHTKD1, HK1, SURF1, COX6A1
multi-organism process (GO:0051704)	2.65	5	RAB7A, LRSAM1, HSPB1, KARS, VCP
negative regulation of developmental process (GO:0051093)	3.17	5	MTMR2, PMP22, TRPV4, FIG4, LMNA
single organism signaling (GO:0044700)	3.25	5	KIF1B, PMP22, SPG11, MPZ, GJB1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	5	MED25, HSPB1, EGR2, VCP, DNM2
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	AIFM1, HSPB1, TRPV4, AARS, VCP
carbohydrate metabolic process (GO:0005975)	3.26	5	MTMR2, DHTKD1, HK1, PDK3, VCP
positive regulation of response to stimulus (GO:0048584)	2.18	5	PLEKHG5, LITAF, LRSAM1, HSPB1, TRPV4
response to external stimulus (GO:0009605)	2.55	5	AIFM1, HSPB1, LITAF, TRPV4, LMNA
positive regulation of developmental process (GO:0051094)	2.77	5	HSPB1, NEFL, FIG4, DNM2, LMNA
ribose phosphate metabolic process (GO:0019693)	4.06	5	PRPS1, DHTKD1, HK1, SURF1, VCP
chemical homeostasis (GO:0048878)	2.97	5	HK1, PDK3, TRPV4, RAB7A, JPH1
purine nucleotide metabolic process (GO:0006163)	4.09	5	PRPS1, SURF1, HK1, DHTKD1, VCP
glycosyl compound metabolic process (GO:1901657)	4.04	5	PRPS1, DHTKD1, HK1, SURF1, VCP
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	5	LITAF, MED25, TRPV4, IGHMBP2, EGR2
cell-cell signaling (GO:0007267)	3.35	5	KIF1B, PMP22, SPG11, MPZ, GJB1
viral process (GO:0016032)	3.15	5	RAB7A, LRSAM1, HSPB1, KARS, VCP
system development (GO:0048731)	2.92	5	NAGLU, PMP22, PRPS1, GJB1, EGR2
nucleoside metabolic process (GO:0009116)	4.12	5	PRPS1, DHTKD1, HK1, SURF1, VCP
regulation of catabolic process (GO:0009894)	3.52	4	MTMR2, RAB7A, AIFM1, VCP
negative regulation of metabolic process (GO:0009892)	1.93	4	MTMR2, MED25, HSPB1, TRPV4
RNA biosynthetic process (GO:0032774)	1.84	4	MED25, LITAF, IGHMBP2, EGR2
regulation of small GTPase mediated signal transduction (GO:0051056)	4.08	4	PLEKHG5, MFN2, DNM2, FGD4
nucleoside triphosphate metabolic process (GO:0009141)	4.61	4	SURF1, HK1, DHTKD1, VCP
regulation of intracellular transport (GO:0032386)	3.58	4	MTMR2, SH3TC2, LITAF, NEFH
cell differentiation (GO:0030154)	2.14	4	DHTKD1, AIFM1, PMP22, EGR2
cell development (GO:0048468)	3.28	4	FIG4, MTMR2, NAGLU, LMNA
nucleotide biosynthetic process (GO:0009165)	4.49	4	SURF1, PRPS1, GARS, KARS
cell cycle process (GO:0022402)	2.75	4	DYNC1H1, MFN2, DNM2, LMNA
generation of precursor metabolites and energy (GO:0006091)	4.07	4	DHTKD1, HK1, SURF1, COX6A1
regulation of neuron death (GO:1901214)	4.19	4	TRIM2, NEFL, AIFM1, AARS
response to organic cyclic compound (GO:0014070)	3.07	4	NEFL, AIFM1, NEFH, DNM2
regulation of protein localization (GO:0032880)	2.88	4	TRPV4, SH3TC2, LITAF, LMNA
myelination (GO:0042552)	5.52	4	SH3TC2, SBF2, PMP22, EGR2
cellular macromolecule localization (GO:0070727)	3.1	4	MFN2, RAB7A, LMNA, GDAP1
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	4	DNM2, HSPB1, NEFL, FGD4
protein modification by small protein conjugation or removal (GO:0070647)	2.95	4	LRSAM1, TRIM2, VCP, EGR2
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	4	DNM2, HSPB1, MED25, EGR2
protein modification by small protein conjugation (GO:0032446)	3.1	4	LRSAM1, TRIM2, VCP, EGR2
ribonucleoside triphosphate metabolic process (GO:0009199)	4.77	4	DHTKD1, HK1, SURF1, VCP
anterograde trans-synaptic signaling (GO:0098916)	3.98	4	PMP22, SPG11, MPZ, KIF1B
nucleic acid-templated transcription (GO:0097659)	1.91	4	MED25, LITAF, IGHMBP2, EGR2
regulation of Ras protein signal transduction (GO:0046578)	4.49	4	PLEKHG5, DNM2, MFN2, FGD4
ATP metabolic process (GO:0046034)	4.98	4	DHTKD1, HK1, SURF1, VCP
response to endoplasmic reticulum stress (GO:0034976)	4.46	4	AARS, AIFM1, LMNA, VCP
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	4	MFN2, MTMR2, FIG4, EGR2
nucleoside phosphate biosynthetic process (GO:1901293)	4.47	4	SURF1, PRPS1, GARS, KARS
regulation of cell proliferation (GO:0042127)	2.41	4	NDRG1, PMP22, MED25, MFN2
negative regulation of cell proliferation (GO:0008285)	3.26	4	NDRG1, PMP22, MED25, MFN2
purine ribonucleoside triphosphate metabolic process (GO:0009205)	4.81	4	SURF1, HK1, DHTKD1, VCP
negative regulation of cellular metabolic process (GO:0031324)	2.01	4	MTMR2, MED25, HSPB1, TRPV4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	4	MED25, EGR2, VCP, DNM2
lipid metabolic process (GO:0006629)	2.68	4	RAB7A, MTMR2, MORC2, FIG4
positive regulation of transport (GO:0051050)	2.9	4	MTMR2, RAB7A, TRPV4, DNM2
purine nucleoside triphosphate metabolic process (GO:0009144)	4.76	4	SURF1, HK1, DHTKD1, VCP
cellular protein localization (GO:0034613)	3.11	4	MFN2, RAB7A, LMNA, GDAP1
cellular response to lipid (GO:0071396)	3.96	4	AIFM1, PDK3, LITAF, NEFH
regulation of vesicle-mediated transport (GO:0060627)	3.63	4	RAB7A, MTMR2, LRSAM1, DNM2
positive regulation of cell differentiation (GO:0045597)	3.01	4	NEFL, FIG4, LMNA, DNM2
reproductive process (GO:0022414)	2.55	4	NEFH, LMNA, SBF1, DNM2
chemical synaptic transmission (GO:0007268)	3.98	4	PMP22, SPG11, MPZ, KIF1B
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	MED25, EGR2, VCP, DNM2
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	4	MTMR2, MED25, HSPB1, TRPV4
cellular lipid metabolic process (GO:0044255)	2.92	4	RAB7A, MORC2, MTMR2, FIG4
cellular protein complex assembly (GO:0043623)	3.9	4	TRPV4, SURF1, AIFM1, NEFL
transmembrane transport (GO:0055085)	2.72	4	SURF1, TRPV4, COX6A1, GJB1
system process (GO:0003008)	2.3	4	NEFL, TRPV4, AARS, EGR2
regulation of cellular component movement (GO:0051270)	3.08	4	HSPB1, NEFH, TRPV4, LMNA
single-multicellular organism process (GO:0044707)	1.78	4	MFN2, TRPV4, AARS, EGR2
response to hormone (GO:0009725)	3.33	4	AIFM1, NEFL, TRPV4, EGR2
regulation of response to stress (GO:0080134)	2.53	4	HSPB1, LRSAM1, TRPV4, HSPB8
microtubule-based movement (GO:0007018)	4.39	4	DYNC1H1, NEFL, SPG11, KIF1B
immune system process (GO:0002376)	2.29	4	NDRG1, DYNC1H1, RAB7A, DNM2
negative regulation of nervous system development (GO:0051961)	4.15	4	MTMR2, PMP22, TRPV4, FIG4
regulation of neuron apoptotic process (GO:0043523)	4.47	4	AIFM1, NEFL, TRIM2, AARS
transcription, DNA-templated (GO:0006351)	1.91	4	MED25, LITAF, IGHMBP2, EGR2
positive regulation of gene expression (GO:0010628)	2.35	4	MED25, TRPV4, DNM2, EGR2
protein localization to organelle (GO:0033365)	3.57	4	MFN2, RAB7A, LMNA, GDAP1
single-organism intracellular transport (GO:1902582)	3.59	4	NEFL, SPG11, KIF1B, LMNA
trans-synaptic signaling (GO:0099537)	3.98	4	PMP22, SPG11, MPZ, KIF1B
synaptic signaling (GO:0099536)	3.98	4	PMP22, SPG11, MPZ, KIF1B
positive regulation of cellular component biogenesis (GO:0044089)	3.71	4	MED25, LRSAM1, VCP, DNM2
regulation of phosphate metabolic process (GO:0019220)	2.35	3	HSPB1, TRPV4, VCP
behavior (GO:0007610)	3.47	3	FIG4, NAGLU, EGR2
carbohydrate homeostasis (GO:0033500)	4.6	3	HK1, PDK3, TRPV4
membrane fusion (GO:0061025)	4.68	3	MFN2, RAB7A, GDAP1
inorganic ion homeostasis (GO:0098771)	3.43	3	RAB7A, TRPV4, JPH1
mitochondrion organization (GO:0007005)	3.69	3	MFN2, GDAP1, HARS
positive regulation of cell projection organization (GO:0031346)	3.99	3	NEFL, FIG4, DNM2
response to unfolded protein (GO:0006986)	5.55	3	MFN2, HSPB1, AARS
positive regulation of signal transduction (GO:0009967)	2.5	3	PLEKHG5, LITAF, TRPV4
peptidyl-amino acid modification (GO:0018193)	2.98	3	PDK3, VCP, EGR2
dephosphorylation (GO:0016311)	4.06	3	FIG4, MTMR2, SBF1
positive regulation of cell development (GO:0010720)	3.57	3	NEFL, FIG4, DNM2
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	3	PLEKHG5, HSPB1, LITAF
negative regulation of transport (GO:0051051)	3.6	3	MTMR2, LRSAM1, LITAF
monocarboxylic acid metabolic process (GO:0032787)	3.57	3	DHTKD1, HK1, MORC2
spermatogenesis (GO:0007283)	3.7	3	DNM2, LMNA, SBF1
establishment of localization by movement along microtubule (GO:0010970)	5.14	3	NEFL, SPG11, KIF1B
protein catabolic process (GO:0030163)	3.93	3	RAB7A, LRSAM1, VCP
establishment of protein localization to mitochondrion (GO:0072655)	5.63	3	MFN2, HK1, GDAP1
response to peptide hormone (GO:0043434)	4.06	3	NEFL, TRPV4, EGR2
regulation of phosphorylation (GO:0042325)	2.5	3	HSPB1, TRPV4, VCP
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504)	5.14	3	DYNC1H1, RAB7A, DNM2
single organism reproductive process (GO:0044702)	2.73	3	DNM2, LMNA, SBF1
endoplasmic reticulum unfolded protein response (GO:0030968)	5.07	3	AARS, LMNA, VCP
protein ubiquitination (GO:0016567)	3.28	3	LRSAM1, TRIM2, VCP
regulation of cell morphogenesis (GO:0022604)	3.4	3	NEFL, DNM2, FGD4
antigen processing and presentation (GO:0019882)	4.36	3	DYNC1H1, RAB7A, DNM2
nicotinamide nucleotide metabolic process (GO:0046496)	5.14	3	DHTKD1, HK1, VCP
antigen processing and presentation of peptide antigen (GO:0048002)	4.56	3	DYNC1H1, RAB7A, DNM2
regulation of protein transport (GO:0051223)	3.12	3	LITAF, SH3TC2, TRPV4
cofactor metabolic process (GO:0051186)	3.91	3	DHTKD1, HK1, VCP
axo-dendritic transport (GO:0008088)	6.12	3	NEFL, SPG11, KIF1B
cellular response to oxygen levels (GO:0071453)	4.97	3	NDRG1, AIFM1, LMNA
inorganic cation transmembrane transport (GO:0098662)	3.55	3	SURF1, TRPV4, COX6A1
inorganic ion transmembrane transport (GO:0098660)	3.38	3	SURF1, TRPV4, COX6A1
regulation of establishment of protein localization (GO:0070201)	3.02	3	TRPV4, SH3TC2, LITAF
antigen processing and presentation of exogenous antigen (GO:0019884)	4.59	3	DYNC1H1, RAB7A, DNM2
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	5.21	3	DYNC1H1, RAB7A, DNM2
single-organism membrane fusion (GO:0044801)	4.89	3	MFN2, RAB7A, GDAP1
negative regulation of intracellular signal transduction (GO:1902532)	3.63	3	HSPB1, MFN2, LITAF
positive regulation of intracellular signal transduction (GO:1902533)	2.95	3	PLEKHG5, LITAF, TRPV4
endocytosis (GO:0006897)	3.69	3	RAB7A, LRSAM1, DNM2
response to decreased oxygen levels (GO:0036293)	4.09	3	NDRG1, AIFM1, LMNA
regulation of cellular response to stress (GO:0080135)	3.4	3	HSPB1, TRPV4, HSPB8
cellular response to decreased oxygen levels (GO:0036294)	5.05	3	NDRG1, AIFM1, LMNA
neuron projection morphogenesis (GO:0048812)	4.34	3	NEFL, NEFH, DNM2
regulation of cell motility (GO:2000145)	3.16	3	HSPB1, TRPV4, LMNA
positive regulation of response to external stimulus (GO:0032103)	4.17	3	HSPB1, LRSAM1, TRPV4
regulation of response to external stimulus (GO:0032101)	3.06	3	HSPB1, LRSAM1, TRPV4
coenzyme metabolic process (GO:0006732)	4.14	3	DHTKD1, HK1, VCP
oxidoreduction coenzyme metabolic process (GO:0006733)	5.03	3	DHTKD1, HK1, VCP
ion homeostasis (GO:0050801)	3.42	3	RAB7A, TRPV4, JPH1
antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)	5.19	3	DYNC1H1, RAB7A, DNM2
cellular catabolic process (GO:0044248)	2.62	3	RAB7A, AIFM1, VCP
positive regulation of cell communication (GO:0010647)	2.41	3	PLEKHG5, LITAF, TRPV4
regeneration (GO:0031099)	4.7	3	NEFL, PRPS1, NEFH
cytoskeleton-dependent intracellular transport (GO:0030705)	4.96	3	NEFL, SPG11, KIF1B
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	3	AIFM1, TRPV4, VCP
regulation of protein modification process (GO:0031399)	2.32	3	HSPB1, TRPV4, VCP
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	MED25, DNM2, EGR2
multicellular organismal reproductive process (GO:0048609)	3.35	3	DNM2, LMNA, SBF1
neurological system process (GO:0050877)	2.64	3	NEFL, AARS, EGR2
cellular ion homeostasis (GO:0006873)	3.57	3	RAB7A, TRPV4, JPH1
cellular response to DNA damage stimulus (GO:0006974)	3.17	3	NDRG1, IGHMBP2, VCP
metal ion transport (GO:0030001)	3.36	3	DNM2, TRPV4, JPH1
response to acid chemical (GO:0001101)	4.05	3	PDK3, GDAP1, AARS
cellular cation homeostasis (GO:0030003)	3.6	3	RAB7A, TRPV4, JPH1
male gamete generation (GO:0048232)	3.7	3	DNM2, LMNA, SBF1
cation homeostasis (GO:0055080)	3.46	3	RAB7A, TRPV4, JPH1
response to oxidative stress (GO:0006979)	3.9	3	NEFH, AIFM1, DNM2
cell projection morphogenesis (GO:0048858)	4.05	3	NEFL, NEFH, DNM2
cellular response to organic cyclic compound (GO:0071407)	3.93	3	NEFH, AIFM1, DNM2
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	MED25, DNM2, EGR2
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	MED25, DNM2, EGR2
regulation of cytokine production (GO:0001817)	3.4	3	LITAF, HSPB1, TRPV4
response to topologically incorrect protein (GO:0035966)	5.45	3	MFN2, HSPB1, AARS
regulation of cellular catabolic process (GO:0031329)	3.83	3	MTMR2, AIFM1, VCP
cell projection assembly (GO:0030031)	4.19	3	PMP22, NEFH, FGD4
mitotic cell cycle process (GO:1903047)	3.12	3	DYNC1H1, DNM2, LMNA
glucose homeostasis (GO:0042593)	4.6	3	HK1, PDK3, TRPV4
pyridine-containing compound metabolic process (GO:0072524)	5.07	3	DHTKD1, HK1, VCP
gamete generation (GO:0007276)	3.61	3	DNM2, LMNA, SBF1
antigen processing and presentation of exogenous peptide antigen (GO:0002478)	4.63	3	DYNC1H1, RAB7A, DNM2
regulation of cellular protein localization (GO:1903827)	3.43	3	SH3TC2, LITAF, LMNA
cellular component morphogenesis (GO:0032989)	3.5	3	NEFL, NEFH, DNM2
organelle fusion (GO:0048284)	4.86	3	MFN2, RAB7A, GDAP1
regulation of autophagy (GO:0010506)	4.21	3	RAB7A, HSPB1, LRSAM1
neuron development (GO:0048666)	4.8	3	FIG4, MTMR2, NAGLU
regulation of cell migration (GO:0030334)	3.23	3	HSPB1, TRPV4, LMNA
Golgi vesicle transport (GO:0048193)	4.07	3	DYNC1H1, DNM2, VCP
autophagy (GO:0006914)	3.82	3	MFN2, LRSAM1, RAB7A
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	HSPB1, TRPV4, VCP
ion transmembrane transport (GO:0034220)	3.08	3	SURF1, TRPV4, COX6A1
cellular macromolecule catabolic process (GO:0044265)	3.19	3	RAB7A, AIFM1, VCP
mitochondrion localization (GO:0051646)	6.15	3	NEFL, MFN2, KIF1B
cellular response to oxidative stress (GO:0034599)	4.7	3	NEFH, AIFM1, DNM2
protein targeting (GO:0006605)	4.08	3	MFN2, RAB7A, GDAP1
regulation of endocytosis (GO:0030100)	4.42	3	LRSAM1, MTMR2, DNM2
positive regulation of signaling (GO:0023056)	2.41	3	PLEKHG5, LITAF, TRPV4
response to oxygen levels (GO:0070482)	4.02	3	NDRG1, AIFM1, LMNA
regulation of locomotion (GO:0040012)	3.12	3	HSPB1, TRPV4, LMNA
cell part morphogenesis (GO:0032990)	3.99	3	NEFL, NEFH, DNM2
nervous system development (GO:0007399)	3.53	3	PRPS1, NAGLU, GJB1
regulation of cell cycle (GO:0051726)	2.93	3	NDRG1, MFN2, MED25
response to peptide (GO:1901652)	3.94	3	NEFL, TRPV4, EGR2
pyridine nucleotide metabolic process (GO:0019362)	5.14	3	DHTKD1, HK1, VCP
DNA metabolic process (GO:0006259)	3.09	3	AIFM1, IGHMBP2, VCP
cation transmembrane transport (GO:0098655)	3.43	3	SURF1, TRPV4, COX6A1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	MED25, DNM2, EGR2
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	2	HSPB1, LMNA
regulation of intracellular protein transport (GO:0033157)	3.8	2	SH3TC2, LITAF
nuclear transport (GO:0051169)	4.2	2	LMNA, EGR2
organophosphate catabolic process (GO:0046434)	5.03	2	MTMR2, VCP
regulation of secretion (GO:0051046)	3.2	2	RAB7A, TRPV4
positive regulation of secretion (GO:0051047)	3.85	2	RAB7A, TRPV4
G2/M transition of mitotic cell cycle (GO:0000086)	4.84	2	DYNC1H1, DNM2
protein dephosphorylation (GO:0006470)	4.47	2	MTMR2, SBF1
spinal cord development (GO:0021510)	6.09	2	NEFL, NEFH
regulation of homeostatic process (GO:0032844)	3.65	2	TRPV4, JPH1
positive regulation of defense response (GO:0031349)	3.83	2	LRSAM1, TRPV4
plasma membrane organization (GO:0007009)	4.8	2	NDRG1, SH3TC2
regulation of chemotaxis (GO:0050920)	4.53	2	HSPB1, TRPV4
positive regulation of chemotaxis (GO:0050921)	4.94	2	HSPB1, TRPV4
small molecule catabolic process (GO:0044282)	3.99	2	MTMR2, HK1
establishment of mitochondrion localization (GO:0051654)	6.9	2	NEFL, KIF1B
regulation of anatomical structure size (GO:0090066)	3.78	2	NEFL, TRPV4
negative regulation of cell projection organization (GO:0031345)	4.72	2	PMP22, TRPV4
establishment of vesicle localization (GO:0051650)	4.91	2	DNM2, SPG11
purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	5.54	2	SURF1, PRPS1
organic cyclic compound catabolic process (GO:1901361)	3.73	2	AIFM1, VCP
muscle organ development (GO:0007517)	4.98	2	JPH1, LMNA
positive regulation of cell cycle (GO:0045787)	3.94	2	NDRG1, MED25
response to external biotic stimulus (GO:0043207)	3.13	2	HSPB1, LITAF
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	HSPB1, AARS
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	HSPB1, LMNA
calcium ion homeostasis (GO:0055074)	3.97	2	TRPV4, JPH1
response to wounding (GO:0009611)	4.39	2	NEFL, NEFH
response to mechanical stimulus (GO:0009612)	4.41	2	TRPV4, LMNA
negative regulation of neuron differentiation (GO:0045665)	4.45	2	PMP22, TRPV4
rhythmic process (GO:0048511)	4.02	2	NAGLU, EGR2
positive regulation of neuron differentiation (GO:0045666)	3.98	2	NEFL, FIG4
regulation of metal ion transport (GO:0010959)	3.94	2	DNM2, JPH1
ribonucleoside biosynthetic process (GO:0042455)	5.06	2	SURF1, PRPS1
ribonucleoside diphosphate metabolic process (GO:0009185)	5.52	2	DHTKD1, HK1
negative regulation of cell development (GO:0010721)	4.02	2	PMP22, TRPV4
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	2	AIFM1, VCP
phosphatidylinositol biosynthetic process (GO:0006661)	4.94	2	FIG4, MTMR2
synaptic vesicle localization (GO:0097479)	5.31	2	DNM2, SPG11
response to salt (GO:1902074)	6.96	2	NEFL, NEFH
axon regeneration (GO:0031103)	6.64	2	NEFL, NEFH
neuron projection regeneration (GO:0031102)	6.29	2	NEFL, NEFH
DNA repair (GO:0006281)	3.59	2	IGHMBP2, VCP
response to corticosteroid (GO:0031960)	4.56	2	NEFL, AIFM1
diadenosine polyphosphate biosynthetic process (GO:0015960)	9.04	2	GARS, KARS
ADP metabolic process (GO:0046031)	5.82	2	DHTKD1, HK1
diadenosine tetraphosphate biosynthetic process (GO:0015966)	9.04	2	GARS, KARS
diadenosine tetraphosphate metabolic process (GO:0015965)	9.04	2	GARS, KARS
response to axon injury (GO:0048678)	5.86	2	NEFL, NEFH
regulation of proteolysis (GO:0030162)	3.2	2	AIFM1, VCP
positive regulation of neuron projection development (GO:0010976)	4.26	2	NEFL, FIG4
mitochondrial transport (GO:0006839)	5.02	2	MFN2, GDAP1
divalent inorganic cation transport (GO:0072511)	4.13	2	TRPV4, JPH1
purine ribonucleoside biosynthetic process (GO:0046129)	5.25	2	SURF1, PRPS1
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	2	FIG4, MTMR2
purine ribonucleoside diphosphate metabolic process (GO:0009179)	5.55	2	DHTKD1, HK1
establishment of synaptic vesicle localization (GO:0097480)	5.33	2	DNM2, SPG11
intermediate filament organization (GO:0045109)	6.73	2	NEFL, NEFH
protein localization to mitochondrion (GO:0070585)	5.74	2	MFN2, GDAP1
positive regulation of phosphorylation (GO:0042327)	2.9	2	TRPV4, VCP
response to biotic stimulus (GO:0009607)	3.09	2	HSPB1, LITAF
organonitrogen compound catabolic process (GO:1901565)	3.91	2	NAGLU, VCP
protein tetramerization (GO:0051262)	5.01	2	SBF2, MTMR2
intermediate filament cytoskeleton organization (GO:0045104)	6.04	2	NEFL, NEFH
positive regulation of organelle organization (GO:0010638)	3.38	2	LRSAM1, TRPV4
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	2	TRPV4, JPH1
vesicle organization (GO:0016050)	4.13	2	RAB7A, LRSAM1
intermediate filament-based process (GO:0045103)	6.02	2	NEFL, NEFH
purine nucleoside biosynthetic process (GO:0042451)	5.25	2	SURF1, PRPS1
nucleoside diphosphate phosphorylation (GO:0006165)	5.65	2	DHTKD1, HK1
purine nucleotide biosynthetic process (GO:0006164)	4.87	2	SURF1, PRPS1
aromatic compound catabolic process (GO:0019439)	3.79	2	AIFM1, VCP
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	NEFL, AARS
positive regulation of cell morphogenesis involved in differentiation (GO:0010770)	4.65	2	NEFL, DNM2
cerebellar Purkinje cell layer development (GO:0021680)	7.24	2	AARS, NAGLU
regulation of cellular component size (GO:0032535)	4.21	2	NEFL, TRPV4
nucleoside biosynthetic process (GO:0009163)	4.97	2	SURF1, PRPS1
positive regulation of catabolic process (GO:0009896)	3.94	2	RAB7A, VCP
regulation of membrane potential (GO:0042391)	3.89	2	MTMR2, VCP
purine ribonucleotide biosynthetic process (GO:0009152)	4.92	2	SURF1, PRPS1
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	2	DNM2, JPH1
carbohydrate catabolic process (GO:0016052)	5.0	2	DHTKD1, HK1
regulation of Rho protein signal transduction (GO:0035023)	5.02	2	PLEKHG5, FGD4
cellular response to reactive nitrogen species (GO:1902170)	6.78	2	DNM2, AIFM1
response to reactive oxygen species (GO:0000302)	4.5	2	DNM2, AIFM1
negative regulation of gene expression (GO:0010629)	2.48	2	MED25, TRPV4
neuron projection development (GO:0031175)	4.58	2	NEFL, NEFH
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	2	PDK3, DNM2
regulation of ERBB signaling pathway (GO:1901184)	5.3	2	SH3TC2, RAB7A
synaptic vesicle transport (GO:0048489)	5.33	2	DNM2, SPG11
ncRNA processing (GO:0034470)	3.77	2	AARS, KARS
positive regulation of cell cycle process (GO:0090068)	4.25	2	NDRG1, MED25
intermediate filament bundle assembly (GO:0045110)	7.94	2	NEFL, NEFH
proton transport (GO:0015992)	4.73	2	SURF1, COX6A1
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	TRPV4, VCP
positive regulation of endopeptidase activity (GO:0010950)	4.78	2	AIFM1, VCP
regulation of peptidase activity (GO:0052547)	3.75	2	AIFM1, VCP
anterograde axonal transport (GO:0008089)	6.47	2	NEFL, KIF1B
regulation of defense response (GO:0031347)	3.11	2	LRSAM1, TRPV4
cellular response to hypoxia (GO:0071456)	5.11	2	NDRG1, LMNA
anatomical structure homeostasis (GO:0060249)	4.25	2	RAB7A, HSPB1
cellular response to abiotic stimulus (GO:0071214)	4.15	2	DNM2, TRPV4
locomotory behavior (GO:0007626)	4.53	2	FIG4, NAGLU
hydrogen transport (GO:0006818)	4.72	2	SURF1, COX6A1
axon development (GO:0061564)	6.36	2	NEFL, NEFH
rhythmic behavior (GO:0007622)	6.78	2	NAGLU, EGR2
positive regulation of cell migration (GO:0030335)	3.77	2	HSPB1, TRPV4
ribonucleoside monophosphate biosynthetic process (GO:0009156)	5.36	2	SURF1, PRPS1
protein targeting to mitochondrion (GO:0006626)	6.17	2	MFN2, GDAP1
hexose metabolic process (GO:0019318)	4.64	2	PDK3, HK1
calcium ion transport (GO:0006816)	4.33	2	TRPV4, JPH1
heterocycle catabolic process (GO:0046700)	3.82	2	AIFM1, VCP
positive regulation of multi-organism process (GO:0043902)	4.68	2	RAB7A, LRSAM1
ribonucleotide biosynthetic process (GO:0009260)	4.82	2	SURF1, PRPS1
regulation of multi-organism process (GO:0043900)	3.6	2	RAB7A, LRSAM1
regulation of autophagosome assembly (GO:2000785)	6.2	2	RAB7A, LRSAM1
positive regulation of proteolysis (GO:0045862)	3.86	2	AIFM1, VCP
nucleobase-containing compound catabolic process (GO:0034655)	3.9	2	AIFM1, VCP
regulation of ossification (GO:0030278)	4.53	2	LMNA, EGR2
negative regulation of neuron death (GO:1901215)	4.57	2	NEFL, AARS
single-organism carbohydrate catabolic process (GO:0044724)	5.07	2	DHTKD1, HK1
regulation of protein localization to nucleus (GO:1900180)	4.34	2	LITAF, LMNA
response to sodium arsenite (GO:1903935)	8.63	2	NEFL, NEFH
cellular nitrogen compound catabolic process (GO:0044270)	3.8	2	AIFM1, VCP
response to acrylamide (GO:1903937)	8.63	2	NEFL, NEFH
phospholipid biosynthetic process (GO:0008654)	4.39	2	FIG4, MTMR2
regulation of neurological system process (GO:0031644)	5.52	2	FIG4, MTMR2
regulation of transmembrane transporter activity (GO:0022898)	4.52	2	DNM2, JPH1
positive regulation of protein modification process (GO:0031401)	2.7	2	TRPV4, VCP
ribose phosphate biosynthetic process (GO:0046390)	4.79	2	SURF1, PRPS1
regulation of myelination (GO:0031641)	6.23	2	FIG4, MTMR2
negative regulation of myelination (GO:0031642)	7.78	2	FIG4, MTMR2
(GO:0098930)	6.26	2	NEFL, KIF1B
positive regulation of protein catabolic process (GO:0045732)	4.18	2	RAB7A, VCP
positive regulation of cell motility (GO:2000147)	3.74	2	HSPB1, TRPV4
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	MED25, TRPV4
protein polymerization (GO:0051258)	5.8	2	NEFL, TRPV4
ATP generation from ADP (GO:0006757)	5.99	2	DHTKD1, HK1
DNA conformation change (GO:0071103)	4.9	2	AIFM1, IGHMBP2
cellular glucose homeostasis (GO:0001678)	5.48	2	PDK3, HK1
NAD metabolic process (GO:0019674)	5.7	2	HK1, VCP
hydrogen ion transmembrane transport (GO:1902600)	4.97	2	SURF1, COX6A1
regulation of cell adhesion (GO:0030155)	3.27	2	DNM2, TRPV4
cellular response to inorganic substance (GO:0071241)	4.67	2	DNM2, AIFM1
response to mineralocorticoid (GO:0051385)	6.23	2	NEFL, AIFM1
NADH metabolic process (GO:0006734)	6.17	2	HK1, VCP
modulation of synaptic transmission (GO:0050804)	4.09	2	MTMR2, EGR2
establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	7.02	2	NEFL, KIF1B
regulation of protein catabolic process (GO:0042176)	3.83	2	RAB7A, VCP
cellular carbohydrate metabolic process (GO:0044262)	4.74	2	MTMR2, HK1
cell-cell junction assembly (GO:0007043)	5.42	2	TRPV4, GJB1
regulation of secretion by cell (GO:1903530)	3.28	2	RAB7A, TRPV4
positive regulation of secretion by cell (GO:1903532)	3.93	2	RAB7A, TRPV4
muscle structure development (GO:0061061)	4.96	2	JPH1, LMNA
regulation of microtubule-based process (GO:0032886)	4.79	2	NEFH, TRPV4
response to hypoxia (GO:0001666)	4.13	2	NDRG1, LMNA
regulation of protein complex assembly (GO:0043254)	3.83	2	MED25, VCP
nucleoside monophosphate biosynthetic process (GO:0009124)	5.26	2	SURF1, PRPS1
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	TRPV4, JPH1
negative regulation of biosynthetic process (GO:0009890)	2.47	2	MED25, TRPV4
neuromuscular process controlling balance (GO:0050885)	5.88	2	NEFL, AARS
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	MED25, TRPV4
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	TRPV4, VCP
mitochondrion transport along microtubule (GO:0047497)	7.02	2	NEFL, KIF1B
regulation of cell cycle process (GO:0010564)	3.5	2	NDRG1, MED25
nucleotide phosphorylation (GO:0046939)	5.54	2	DHTKD1, HK1
negative regulation of neurogenesis (GO:0050768)	4.22	2	PMP22, TRPV4
positive regulation of neurogenesis (GO:0050769)	3.77	2	NEFL, FIG4
regulation of transporter activity (GO:0032409)	4.45	2	DNM2, JPH1
regulation of cell morphogenesis involved in differentiation (GO:0010769)	3.91	2	NEFL, DNM2
monovalent inorganic cation transport (GO:0015672)	3.74	2	SURF1, COX6A1
cellular response to endogenous stimulus (GO:0071495)	3.33	2	DNM2, AIFM1
phospholipid metabolic process (GO:0006644)	3.88	2	FIG4, MTMR2
tRNA processing (GO:0008033)	4.96	2	AARS, KARS
regulation of body fluid levels (GO:0050878)	3.76	2	MFN2, TRPV4
cellular response to estradiol stimulus (GO:0071392)	6.29	2	NEFH, AIFM1
neurofilament cytoskeleton organization (GO:0060052)	7.53	2	NEFL, NEFH
positive regulation of protein complex assembly (GO:0031334)	4.44	2	MED25, VCP
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	HSPB1, AARS
negative regulation of cell differentiation (GO:0045596)	3.33	2	PMP22, TRPV4
regulation of system process (GO:0044057)	3.53	2	FIG4, MTMR2
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	MED25, TRPV4
positive regulation of cysteine-type endopeptidase activity (GO:2001056)	4.88	2	AIFM1, VCP
cell-cell junction organization (GO:0045216)	4.66	2	TRPV4, GJB1
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	4.96	2	AIFM1, VCP
response to alkaloid (GO:0043279)	4.83	2	NEFH, DNM2
tissue homeostasis (GO:0001894)	4.78	2	RAB7A, HSPB1
nucleoside diphosphate metabolic process (GO:0009132)	5.26	2	DHTKD1, HK1
purine nucleoside diphosphate metabolic process (GO:0009135)	5.55	2	DHTKD1, HK1
cell junction assembly (GO:0034329)	4.86	2	TRPV4, GJB1
myelin maintenance (GO:0043217)	7.24	2	NDRG1, SH3TC2
vacuole organization (GO:0007033)	4.67	2	FIG4, NAGLU
divalent metal ion transport (GO:0070838)	4.15	2	TRPV4, JPH1
regulation of axonogenesis (GO:0050770)	4.59	2	NEFL, DNM2
carbohydrate derivative biosynthetic process (GO:1901137)	3.73	2	SURF1, PRPS1
monosaccharide metabolic process (GO:0005996)	4.57	2	PDK3, HK1
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	MED25, TRPV4
peripheral nervous system development (GO:0007422)	6.47	2	PMP22, EGR2
regulation of cation transmembrane transport (GO:1904062)	4.4	2	DNM2, JPH1
neurofilament bundle assembly (GO:0033693)	8.63	2	NEFL, NEFH
negative regulation of neuron projection development (GO:0010977)	4.88	2	PMP22, TRPV4
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	TRPV4, JPH1
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	MED25, TRPV4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	MED25, EGR2
negative regulation of neurological system process (GO:0031645)	7.02	2	FIG4, MTMR2
glycerophospholipid biosynthetic process (GO:0046474)	4.62	2	FIG4, MTMR2
glucose metabolic process (GO:0006006)	4.94	2	PDK3, HK1
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	4.54	2	PLEKHG5, LITAF
response to steroid hormone (GO:0048545)	4.24	2	NEFL, AIFM1
positive regulation of cytokine production (GO:0001819)	3.82	2	HSPB1, TRPV4
glycerolipid metabolic process (GO:0046486)	3.91	2	FIG4, MTMR2
peripheral nervous system myelin maintenance (GO:0032287)	7.78	2	NDRG1, SH3TC2
cellular response to nitrogen compound (GO:1901699)	3.79	2	DNM2, AIFM1
glycerophospholipid metabolic process (GO:0006650)	4.13	2	FIG4, MTMR2
cell cycle G2/M phase transition (GO:0044839)	4.82	2	DYNC1H1, DNM2
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	TRPV4, JPH1
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	MED25, TRPV4
organelle transport along microtubule (GO:0072384)	5.63	2	NEFL, KIF1B
cell junction organization (GO:0034330)	4.51	2	TRPV4, GJB1
macroautophagy (GO:0016236)	4.3	2	MFN2, RAB7A
myelin assembly (GO:0032288)	7.43	2	FIG4, MTMR2
actin cytoskeleton organization (GO:0030036)	4.1	2	TRPV4, FGD4
cell cycle phase transition (GO:0044770)	4.24	2	DYNC1H1, DNM2
mitotic cell cycle phase transition (GO:0044772)	4.27	2	DYNC1H1, DNM2
regulation of transmembrane transport (GO:0034762)	3.74	2	DNM2, JPH1
neuromuscular process (GO:0050905)	5.27	2	NEFL, AARS
response to insulin (GO:0032868)	4.72	2	TRPV4, EGR2
purine-containing compound biosynthetic process (GO:0072522)	4.79	2	SURF1, PRPS1
diadenosine polyphosphate metabolic process (GO:0015959)	8.63	2	GARS, KARS
glycolytic process (GO:0006096)	6.02	2	DHTKD1, HK1
regulation of ion transport (GO:0043269)	3.4	2	DNM2, JPH1
brain development (GO:0007420)	4.24	2	NEFH, EGR2
glycerolipid biosynthetic process (GO:0045017)	4.53	2	FIG4, MTMR2
response to estradiol (GO:0032355)	4.73	2	NEFH, AIFM1
pyruvate metabolic process (GO:0006090)	5.51	2	DHTKD1, HK1
regulation of ion transmembrane transport (GO:0034765)	3.77	2	DNM2, JPH1
positive regulation of nervous system development (GO:0051962)	3.64	2	NEFL, FIG4
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	2	AIFM1, VCP
protein homooligomerization (GO:0051260)	4.21	2	IGHMBP2, VCP
response to toxic substance (GO:0009636)	4.88	2	NEFL, AIFM1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	MED25, TRPV4
hippocampus development (GO:0021766)	5.6	2	NEFL, NEFH
cerebral cortex development (GO:0021987)	5.57	2	NEFL, NEFH
nitrogen compound transport (GO:0071705)	3.54	2	TRPV4, GJB1
cellular metal ion homeostasis (GO:0006875)	3.75	2	TRPV4, JPH1
regulation of organelle assembly (GO:1902115)	4.7	2	RAB7A, LRSAM1
cellular calcium ion homeostasis (GO:0006874)	4.01	2	TRPV4, JPH1
response to arsenic-containing substance (GO:0046685)	6.43	2	NEFL, NEFH
regulation of macroautophagy (GO:0016241)	4.98	2	RAB7A, LRSAM1
protein phosphorylation (GO:0006468)	2.89	2	NEFL, PDK3
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	MED25, TRPV4
actin filament-based process (GO:0030029)	3.94	2	TRPV4, FGD4
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	5.26	2	AIFM1, VCP
regulation of endopeptidase activity (GO:0052548)	3.8	2	AIFM1, VCP
cellular response to reactive oxygen species (GO:0034614)	5.22	2	DNM2, AIFM1
nucleocytoplasmic transport (GO:0006913)	4.23	2	LMNA, EGR2
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	MED25, TRPV4
mitochondrial fusion (GO:0008053)	6.9	2	MFN2, GDAP1
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	MED25, TRPV4
metal ion homeostasis (GO:0055065)	3.61	2	TRPV4, JPH1
response to cocaine (GO:0042220)	5.99	2	NEFH, DNM2
ER to Golgi vesicle-mediated transport (GO:0006888)	4.7	2	DYNC1H1, VCP
positive regulation of peptidase activity (GO:0010952)	4.7	2	AIFM1, VCP
lipid biosynthetic process (GO:0008610)	3.49	2	FIG4, MTMR2
locomotion (GO:0040011)	2.91	2	PLEKHG5, NEFL
positive regulation of cellular component movement (GO:0051272)	3.71	2	HSPB1, TRPV4
regulation of protein phosphorylation (GO:0001932)	2.57	2	HSPB1, TRPV4
chromosome organization (GO:0051276)	3.79	2	AIFM1, IGHMBP2
positive regulation of locomotion (GO:0040017)	3.71	2	HSPB1, TRPV4
vesicle localization (GO:0051648)	4.85	2	DNM2, SPG11
response to nitric oxide (GO:0071731)	6.68	2	DNM2, AIFM1
cellular response to nitric oxide (GO:0071732)	7.02	2	DNM2, AIFM1
response to ketone (GO:1901654)	4.53	2	NEFL, AIFM1
purine nucleoside monophosphate biosynthetic process (GO:0009127)	5.54	2	SURF1, PRPS1
RNA processing (GO:0006396)	3.01	2	AARS, KARS
regulation of translation (GO:0006417)	3.96	2	HSPB1, AARS
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	FIG4, MTMR2
negative regulation of endocytosis (GO:0045806)	6.04	2	LRSAM1, MTMR2
regulation of vacuole organization (GO:0044088)	6.02	2	RAB7A, LRSAM1
glycosyl compound biosynthetic process (GO:1901659)	4.95	2	SURF1, PRPS1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of cellular localization (GO:0060341)	-	3.03	0.04	MFN2, DNM2, TRPV4, GJB1, KARS, DYNC1H1, AIFM1, NEFL, MTMR2, EGR2, LMNA, PRX, LRSAM1, HSPB1, SBF1, RAB7A, LITAF, SH3TC2, KIF1B, NEFH
membrane organization (GO:0061024)	-	3.04	0.048	DNM2, GJB1, NDRG1, MFN2, LRSAM1, LMNA, SH3TC2, RAB7A
small molecule metabolic process (GO:0044281)	-	2.38	0.0	PRPS1, VCP, MFN2, FIG4, MARS, AARS, KIF1B, DNM2, HARS, PDK3, IGHMBP2, YARS, DYNC1H1, HK1, RAB7A, KARS, MTMR2, COX6A1, NAGLU, SURF1, DHTKD1, GARS
ncRNA metabolic process (GO:0034660)	-	3.44	0.019	YARS, KARS, VCP, GARS, MARS, LMNA, MED25, HSPB1, HARS, AARS
ensheathment of neurons (GO:0007272)	-	5.48	0.024	SBF2, GJB1, PMP22, MTMR2, EGR2, PRX
diadenosine polyphosphate metabolic process (GO:0015959)	-	8.63	0.023	GARS, KARS
cell death (GO:0008219)	-	3.05	0.0	PRPS1, GDAP1, MFN2, LRSAM1, GARS, AARS, MPZ, AIFM1, KIF1B, SBF2, TRPV4, GJB1, MARS, PRX, MED25, HSPB1, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, DNM2, TRIM2, NEFH, SPG11, DHTKD1, SH3TC2, KARS, NDRG1, NEFL, MTMR2, FIG4, EGR2, HSPB8, RAB7A, PMP22
single-organism process (GO:0044699)	-	0.48	0.0	PRPS1, COX6A1, GDAP1, PLEKHG5, MFN2, MARS, LRSAM1, NAGLU, AARS, MPZ, AIFM1, FGD4, SBF2, TRPV4, VCP, HARS, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, DNM2, TRIM2, NEFH, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, GJB1, NEFL, MTMR2, FIG4, EGR2, SURF1, HSPB8, RAB7A, PMP22, GARS
response to unfolded protein (GO:0006986)	-	5.55	0.043	AARS, VCP, NAGLU, LMNA, HSPB1, HSPB8, RAB7A
macromolecular complex assembly (GO:0065003)	-	2.55	0.002	GJB1, COX6A1, NAGLU, MPZ, AIFM1, KIF1B, DNM2, TRPV4, VCP, HARS, HSPB1, LMNA, IGHMBP2, SBF1, DYNC1H1, SBF2, JPH1, NDRG1, NEFL, MTMR2, EGR2, SURF1, RAB7A
diadenosine polyphosphate biosynthetic process (GO:0015960)	-	9.04	0.034	GARS, KARS
establishment of protein localization to organelle (GO:0072594)	-	3.92	0.043	DNM2, GDAP1, VCP, MFN2, PRX, COX6A1, HSPB1, LMNA, RAB7A
cellular process (GO:0009987)	-	0.26	0.032	VCP, PRPS1, COX6A1, GJB1, PLEKHG5, MFN2, MARS, LRSAM1, EGR2, AARS, MPZ, AIFM1, FGD4, DNM2, TRPV4, GDAP1, HARS, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, SBF2, TRIM2, NEFH, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, NEFL, MTMR2, FIG4, NAGLU, SURF1, HSPB8, RAB7A, PMP22, GARS
diadenosine tetraphosphate biosynthetic process (GO:0015966)	-	9.04	0.034	GARS, KARS
diadenosine tetraphosphate metabolic process (GO:0015965)	-	9.04	0.008	GARS, KARS
nucleotide metabolic process (GO:0009117)	-	3.73	0.03	DNM2, PRPS1, KARS, VCP, DYNC1H1, MFN2, GARS, SURF1, IGHMBP2, RAB7A, KIF1B
axon ensheathment (GO:0008366)	-	5.48	0.024	SBF2, GJB1, PMP22, MTMR2, EGR2, PRX
protein complex assembly (GO:0006461)	-	2.78	0.001	VCP, COX6A1, NAGLU, MPZ, AIFM1, KIF1B, SBF2, TRPV4, GJB1, HARS, HSPB1, SBF1, IGHMBP2, DYNC1H1, DNM2, JPH1, NDRG1, NEFL, MTMR2, EGR2, SURF1, RAB7A
organonitrogen compound metabolic process (GO:1901564)	-	2.32	0.01	DNM2, PRPS1, VCP, KARS, DYNC1H1, MFN2, GARS, MARS, IGHMBP2, SURF1, HARS, NAGLU, AARS, RAB7A, KIF1B, YARS
neurofilament bundle assembly (GO:0033693)	-	8.63	0.023	NEFL, NEFH
tRNA metabolic process (GO:0006399)	-	4.52	0.024	YARS, KARS, GARS, MARS, HSPB1, HARS, AARS
amino acid activation (GO:0043038)	-	5.76	0.0	KARS, YARS, GARS, MARS, HARS, AARS
tRNA aminoacylation (GO:0043039)	-	5.76	0.0	KARS, YARS, GARS, MARS, HARS, AARS
tRNA aminoacylation for protein translation (GO:0006418)	-	5.82	0.0	KARS, YARS, GARS, MARS, HARS, AARS
organophosphate metabolic process (GO:0019637)	-	3.04	0.005	DNM2, PRPS1, VCP, KARS, DYNC1H1, MTMR2, MFN2, HK1, SURF1, GARS, FIG4, IGHMBP2, RAB7A, KIF1B
single-organism cellular process (GO:0044763)	-	0.65	0.0	PRPS1, COX6A1, GDAP1, PLEKHG5, MFN2, MARS, LRSAM1, NAGLU, AARS, MPZ, AIFM1, FGD4, DNM2, TRPV4, VCP, HARS, PRX, MED25, HSPB1, KIF1B, SBF1, PDK3, LITAF, IGHMBP2, LMNA, YARS, DYNC1H1, HK1, SBF2, TRIM2, NEFH, SPG11, DHTKD1, SH3TC2, KARS, JPH1, NDRG1, GJB1, NEFL, MTMR2, FIG4, EGR2, SURF1, HSPB8, RAB7A, PMP22, GARS
nucleoside phosphate metabolic process (GO:0006753)	-	3.71	0.032	DNM2, PRPS1, KARS, VCP, DYNC1H1, MFN2, GARS, SURF1, IGHMBP2, RAB7A, KIF1B

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	48	PRPS1, COX6A1, GDAP1, PLEKHG5, MFN2, MARS, FIG4, NAGLU, AARS, MPZ, AIFM1, NEFH, FGD4, DNM2, TRPV4, VCP, HARS, PRX, MED25, HSPB1, KIF1B, SBF1, PDK3, LITAF, IGHMBP2, LMNA, YARS, DYNC1H1, HK1, SBF2, TRIM2, MORC2, SPG11, DHTKD1, SH3TC2, KARS, JPH1, NDRG1, GJB1, NEFL, MTMR2, LRSAM1, EGR2, SURF1, HSPB8, RAB7A, PMP22, GARS
intracellular part (GO:0044424)	0.28	47	VCP, PRPS1, COX6A1, GJB1, PLEKHG5, MFN2, MARS, FIG4, NAGLU, AARS, MPZ, AIFM1, NEFH, FGD4, DNM2, TRPV4, GDAP1, HARS, PRX, MED25, HSPB1, KIF1B, SBF1, PDK3, LITAF, IGHMBP2, LMNA, YARS, DYNC1H1, HK1, SBF2, TRIM2, MORC2, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, NEFL, MTMR2, LRSAM1, EGR2, SURF1, HSPB8, RAB7A, GARS
membrane-bounded organelle (GO:0043227)	0.47	42	EGR2, VCP, GJB1, PLEKHG5, MFN2, MARS, FIG4, GARS, AARS, MPZ, AIFM1, NEFH, FGD4, DNM2, TRPV4, GDAP1, HARS, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, MORC2, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, MTMR2, COX6A1, NAGLU, SURF1, HSPB8, RAB7A
organelle (GO:0043226)	0.4	42	EGR2, VCP, GJB1, PLEKHG5, MFN2, MARS, FIG4, GARS, AARS, MPZ, AIFM1, NEFH, FGD4, DNM2, TRPV4, GDAP1, HARS, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, MORC2, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, MTMR2, COX6A1, NAGLU, SURF1, HSPB8, RAB7A
intracellular organelle (GO:0043229)	0.51	41	EGR2, VCP, GJB1, PLEKHG5, MFN2, FIG4, GARS, AARS, MPZ, AIFM1, MORC2, FGD4, DNM2, TRPV4, GDAP1, HARS, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, NEFH, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, MTMR2, COX6A1, NAGLU, SURF1, HSPB8, RAB7A
cytoplasmic part (GO:0044444)	0.82	40	VCP, PRPS1, GDAP1, PLEKHG5, MFN2, MARS, FIG4, GARS, AARS, MPZ, AIFM1, NEFH, FGD4, SBF2, TRPV4, GJB1, HARS, HSPB1, KIF1B, LMNA, PDK3, LITAF, YARS, DYNC1H1, HK1, DNM2, MORC2, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, NEFL, MTMR2, COX6A1, NAGLU, SURF1, HSPB8, RAB7A
intracellular membrane-bounded organelle (GO:0043231)	0.6	39	VCP, GJB1, PLEKHG5, MFN2, FIG4, EGR2, AARS, MPZ, AIFM1, NEFH, FGD4, DNM2, GDAP1, HARS, PRX, MED25, HSPB1, KIF1B, SBF1, PDK3, LITAF, IGHMBP2, LMNA, YARS, HK1, MORC2, SPG11, DHTKD1, SH3TC2, KARS, JPH1, NDRG1, MTMR2, COX6A1, NAGLU, SURF1, HSPB8, RAB7A, GARS
cytoplasm (GO:0005737)	1.01	32	GDAP1, PLEKHG5, MARS, LRSAM1, GARS, AARS, AIFM1, NEFH, FGD4, SBF2, VCP, HARS, PRX, HSPB1, KIF1B, LMNA, LITAF, IGHMBP2, YARS, DYNC1H1, DNM2, TRIM2, MORC2, SPG11, KARS, NDRG1, GJB1, NEFL, MTMR2, EGR2, HSPB8, RAB7A
membrane (GO:0016020)	0.68	32	VCP, GJB1, PLEKHG5, MFN2, FIG4, LRSAM1, AARS, MPZ, AIFM1, KIF1B, DNM2, TRPV4, GDAP1, MARS, PRX, HSPB1, LMNA, LITAF, IGHMBP2, DYNC1H1, HK1, SBF2, SPG11, SH3TC2, JPH1, KARS, NDRG1, PMP22, MTMR2, COX6A1, SURF1, RAB7A
intracellular organelle part (GO:0044446)	0.81	31	VCP, GDAP1, MFN2, FIG4, GARS, AIFM1, KIF1B, SBF2, TRPV4, GJB1, MED25, HSPB1, LMNA, PDK3, LITAF, DYNC1H1, HK1, DNM2, NEFH, SPG11, DHTKD1, JPH1, KARS, NDRG1, NEFL, MTMR2, COX6A1, NAGLU, SURF1, HSPB8, RAB7A
organelle part (GO:0044422)	0.79	31	VCP, GDAP1, MFN2, FIG4, GARS, AIFM1, KIF1B, SBF2, TRPV4, GJB1, MED25, HSPB1, LMNA, PDK3, LITAF, DYNC1H1, HK1, DNM2, NEFH, SPG11, DHTKD1, JPH1, KARS, NDRG1, NEFL, MTMR2, COX6A1, NAGLU, SURF1, HSPB8, RAB7A
cytosol (GO:0005829)	1.68	24	PRPS1, VCP, PLEKHG5, MFN2, MARS, AARS, AIFM1, FGD4, DNM2, HARS, HSPB1, LMNA, YARS, DYNC1H1, HK1, MORC2, SPG11, DHTKD1, KARS, NDRG1, NEFL, MTMR2, GARS, RAB7A
membrane part (GO:0044425)	0.95	19	MTMR2, VCP, TRPV4, GDAP1, GJB1, LITAF, PMP22, HK1, FIG4, JPH1, COX6A1, SURF1, SBF1, DNM2, AIFM1, RAB7A, MPZ, SPG11, MFN2
nucleus (GO:0005634)	1.07	19	VCP, YARS, HSPB8, GDAP1, NDRG1, AIFM1, KARS, DNM2, EGR2, LMNA, PRX, MTMR2, MED25, HSPB1, SBF1, MORC2, SPG11, NEFH, IGHMBP2
organelle membrane (GO:0031090)	1.97	17	SBF2, SPG11, GDAP1, JPH1, NDRG1, AIFM1, MFN2, HK1, DNM2, COX6A1, MTMR2, FIG4, SURF1, LMNA, RAB7A, LITAF, KIF1B
vesicle (GO:0031982)	1.64	16	NDRG1, DNM2, TRPV4, VCP, PLEKHG5, MTMR2, GARS, MARS, DYNC1H1, HSPB1, NAGLU, AARS, SH3TC2, SPG11, RAB7A, KIF1B
protein complex (GO:0043234)	1.51	15	DNM2, PRPS1, KARS, GJB1, DYNC1H1, NEFL, VCP, COX6A1, JPH1, MED25, HSPB1, IGHMBP2, DHTKD1, RAB7A, KIF1B
macromolecular complex (GO:0032991)	1.35	15	DNM2, PRPS1, VCP, GJB1, DYNC1H1, DHTKD1, NEFL, COX6A1, JPH1, MED25, HSPB1, IGHMBP2, RAB7A, KARS, KIF1B
integral component of membrane (GO:0016021)	1.14	14	TRPV4, GDAP1, GJB1, SPG11, PMP22, FIG4, JPH1, COX6A1, SURF1, SBF1, AIFM1, MPZ, LITAF, MFN2
plasma membrane (GO:0005886)	1.39	14	DNM2, TRPV4, KARS, GJB1, PLEKHG5, SPG11, PMP22, PRX, NDRG1, HSPB1, SH3TC2, MPZ, LITAF, JPH1
mitochondrion (GO:0005739)	2.42	14	KARS, GDAP1, MFN2, HK1, SURF1, HARS, COX6A1, GARS, AARS, NEFH, PDK3, AIFM1, DHTKD1, KIF1B
intrinsic component of membrane (GO:0031224)	1.13	14	TRPV4, GDAP1, GJB1, SPG11, PMP22, SURF1, COX6A1, JPH1, FIG4, SBF1, AIFM1, MPZ, LITAF, MFN2
membrane-bounded vesicle (GO:0031988)	1.71	14	DNM2, VCP, PLEKHG5, MTMR2, GARS, NAGLU, DYNC1H1, HSPB1, MARS, AARS, RAB7A, SPG11, NDRG1, KIF1B
cell projection (GO:0042995)	2.47	13	DNM2, TRPV4, PLEKHG5, MTMR2, NEFL, HK1, GARS, IGHMBP2, DYNC1H1, FGD4, NEFH, SPG11, KIF1B
extracellular region part (GO:0044421)	1.57	13	DNM2, YARS, VCP, DYNC1H1, MTMR2, GARS, NAGLU, NDRG1, HSPB1, MARS, AARS, RAB7A, SPG11
extracellular organelle (GO:0043230)	1.89	12	DNM2, VCP, DYNC1H1, MTMR2, GARS, NAGLU, NDRG1, HSPB1, MARS, AARS, RAB7A, SPG11
extracellular exosome (GO:0070062)	1.89	12	DNM2, VCP, DYNC1H1, MTMR2, GARS, MARS, NDRG1, HSPB1, NAGLU, AARS, RAB7A, SPG11
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	12	DNM2, TRPV4, VCP, KARS, DYNC1H1, MFN2, NDRG1, HSPB1, FGD4, RAB7A, SPG11, KIF1B
bounding membrane of organelle (GO:0098588)	2.39	12	SBF2, JPH1, GDAP1, NDRG1, SPG11, MFN2, HK1, DNM2, MTMR2, FIG4, RAB7A, LITAF
non-membrane-bounded organelle (GO:0043228)	1.76	12	DNM2, TRPV4, VCP, KARS, DYNC1H1, MFN2, NDRG1, HSPB1, KIF1B, RAB7A, SPG11, FGD4
extracellular vesicle (GO:1903561)	1.89	12	DNM2, VCP, DYNC1H1, MTMR2, GARS, NAGLU, NDRG1, HSPB1, MARS, AARS, RAB7A, SPG11
whole membrane (GO:0098805)	2.85	11	SBF2, GDAP1, NDRG1, SPG11, MFN2, HK1, DNM2, MTMR2, FIG4, RAB7A, LITAF
neuron part (GO:0097458)	2.64	10	DNM2, TRPV4, NEFL, MTMR2, GARS, IGHMBP2, RAB7A, SPG11, NEFH, KIF1B
mitochondrial part (GO:0044429)	2.92	10	KARS, GDAP1, MFN2, HK1, COX6A1, GARS, SURF1, DHTKD1, AIFM1, PDK3
cytoskeleton (GO:0005856)	2.55	9	DNM2, TRPV4, KARS, DYNC1H1, MFN2, NDRG1, HSPB1, FGD4, KIF1B
cytoplasmic vesicle (GO:0031410)	2.87	9	DNM2, TRPV4, PLEKHG5, MTMR2, GARS, RAB7A, SPG11, SH3TC2, KIF1B
cytoskeletal part (GO:0044430)	2.49	9	DNM2, TRPV4, DYNC1H1, NEFL, NDRG1, HSPB1, LMNA, NEFH, KIF1B
intracellular vesicle (GO:0097708)	2.86	9	DNM2, TRPV4, PLEKHG5, MTMR2, GARS, RAB7A, SPG11, SH3TC2, KIF1B
supramolecular fiber (GO:0099512)	3.31	8	DNM2, TRPV4, DYNC1H1, NEFL, NDRG1, LMNA, NEFH, KIF1B
polymeric cytoskeletal fiber (GO:0099513)	3.31	8	DNM2, TRPV4, DYNC1H1, NEFL, NDRG1, LMNA, NEFH, KIF1B
vacuole (GO:0005773)	2.92	8	DNM2, MPZ, MTMR2, NAGLU, FIG4, RAB7A, LITAF, SH3TC2
cell projection part (GO:0044463)	2.97	8	DNM2, TRPV4, MTMR2, NEFL, HK1, IGHMBP2, RAB7A, KIF1B
vacuolar part (GO:0044437)	3.26	8	SBF2, NDRG1, SPG11, MTMR2, NAGLU, FIG4, RAB7A, LITAF
cell junction (GO:0030054)	2.75	8	DNM2, TRPV4, GJB1, PLEKHG5, PMP22, PRX, NDRG1, HSPB1
nuclear part (GO:0044428)	1.55	7	LMNA, VCP, LITAF, GARS, MED25, HSPB8, SPG11
neuron projection (GO:0043005)	3.12	7	NEFL, MTMR2, GARS, IGHMBP2, NEFH, SPG11, KIF1B
vacuolar membrane (GO:0005774)	3.45	7	SBF2, NDRG1, LITAF, MTMR2, FIG4, RAB7A, SPG11
Golgi apparatus (GO:0005794)	2.7	6	DNM2, FIG4, HSPB8, RAB7A, LITAF, FGD4
organelle lumen (GO:0043233)	3.05	6	KARS, NAGLU, GARS, DHTKD1, AIFM1, PDK3
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	6	DNM2, PLEKHG5, MTMR2, GARS, RAB7A, KIF1B
membrane-enclosed lumen (GO:0031974)	3.05	6	KARS, NAGLU, GARS, DHTKD1, AIFM1, PDK3
axon (GO:0030424)	4.15	6	NEFL, MTMR2, GARS, NEFH, SPG11, IGHMBP2
nucleoplasm (GO:0005654)	1.89	6	LMNA, VCP, GARS, MED25, HSPB8, LITAF
myelin sheath (GO:0043209)	4.76	6	VCP, NDRG1, NEFL, PRX, MPZ, NEFH
intracellular organelle lumen (GO:0070013)	3.05	6	KARS, NAGLU, GARS, DHTKD1, AIFM1, PDK3
perinuclear region of cytoplasm (GO:0048471)	3.35	6	DNM2, VCP, PLEKHG5, NDRG1, LMNA, AIFM1
mitochondrial membrane (GO:0031966)	3.31	6	GDAP1, MFN2, HK1, COX6A1, SURF1, AIFM1
endosome (GO:0005768)	3.25	5	RAB7A, SH3TC2, MTMR2, FIG4, DNM2
plasma membrane part (GO:0044459)	1.95	5	MTMR2, MPZ, TRPV4, DNM2, GJB1
microtubule (GO:0005874)	3.81	5	NDRG1, DYNC1H1, DNM2, TRPV4, KIF1B
endoplasmic reticulum (GO:0005783)	2.56	5	JPH1, FIG4, MPZ, VCP, GJB1
plasma membrane region (GO:0098590)	2.97	4	MTMR2, MPZ, TRPV4, DNM2
lytic vacuole (GO:0000323)	3.89	4	RAB7A, LITAF, MPZ, NAGLU
cell-cell junction (GO:0005911)	3.85	4	NDRG1, PLEKHG5, PMP22, GJB1
lamellipodium (GO:0030027)	4.73	4	PLEKHG5, DNM2, TRPV4, FGD4
anchoring junction (GO:0070161)	3.61	4	NDRG1, TRPV4, DNM2, HSPB1
site of polarized growth (GO:0030427)	4.85	4	NEFL, TRPV4, DNM2, IGHMBP2
growth cone (GO:0030426)	4.89	4	NEFL, TRPV4, DNM2, IGHMBP2
intracellular (GO:0005622)	2.37	4	HSPB1, RAB7A, TRIM2, HSPB8
mitochondrial membrane part (GO:0044455)	4.54	4	SURF1, MFN2, COX6A1, GDAP1
membrane protein complex (GO:0098796)	2.84	4	RAB7A, COX6A1, GJB1, VCP
adherens junction (GO:0005912)	3.66	4	NDRG1, HSPB1, DNM2, TRPV4
endosomal part (GO:0044440)	3.73	4	NDRG1, RAB7A, MTMR2, FIG4
mitochondrial matrix (GO:0005759)	4.03	4	DHTKD1, PDK3, KARS, GARS
lysosome (GO:0005764)	3.89	4	MPZ, LITAF, RAB7A, NAGLU
endosome membrane (GO:0010008)	3.83	4	NDRG1, RAB7A, MTMR2, FIG4
endoplasmic reticulum membrane (GO:0005789)	2.95	3	JPH1, GJB1, VCP
filopodium (GO:0030175)	5.48	3	DYNC1H1, TRPV4, FGD4
cell-substrate adherens junction (GO:0005924)	3.83	3	HSPB1, DNM2, TRPV4
focal adhesion (GO:0005925)	3.83	3	HSPB1, DNM2, TRPV4
cell-substrate junction (GO:0030055)	3.82	3	HSPB1, DNM2, TRPV4
mitochondrial inner membrane (GO:0005743)	3.65	3	SURF1, AIFM1, COX6A1
centrosome (GO:0005813)	3.75	3	NDRG1, DYNC1H1, DNM2
microtubule organizing center (GO:0005815)	3.42	3	NDRG1, DYNC1H1, DNM2
cytoplasmic vesicle part (GO:0044433)	3.41	3	RAB7A, DNM2, KIF1B
endoplasmic reticulum part (GO:0044432)	2.73	3	JPH1, GJB1, VCP
synapse part (GO:0044456)	3.42	3	RAB7A, MTMR2, DNM2
organelle outer membrane (GO:0031968)	4.63	3	MFN2, HK1, GDAP1
microtubule cytoskeleton (GO:0015630)	4.78	3	NDRG1, MFN2, KARS
catalytic complex (GO:1902494)	2.9	3	DYNC1H1, DHTKD1, PRPS1
secretory vesicle (GO:0099503)	4.0	3	RAB7A, MTMR2, GARS
cytoplasmic vesicle membrane (GO:0030659)	3.67	3	RAB7A, DNM2, KIF1B
intermediate filament (GO:0005882)	4.48	3	NEFL, NEFH, LMNA
vesicle membrane (GO:0012506)	3.63	3	RAB7A, DNM2, KIF1B
endocytic vesicle (GO:0030139)	5.04	3	PLEKHG5, RAB7A, DNM2
organelle inner membrane (GO:0019866)	3.56	3	SURF1, AIFM1, COX6A1
outer membrane (GO:0019867)	4.6	3	MFN2, HK1, GDAP1
lysosomal membrane (GO:0005765)	4.19	3	LITAF, RAB7A, SPG11
mitochondrial outer membrane (GO:0005741)	4.76	3	MFN2, HK1, GDAP1
actin-based cell projection (GO:0098858)	4.83	3	DYNC1H1, TRPV4, FGD4
axon part (GO:0033267)	4.4	3	NEFL, RAB7A, KIF1B
lytic vacuole membrane (GO:0098852)	4.19	3	SPG11, RAB7A, LITAF
lipid particle (GO:0005811)	5.66	2	RAB7A, VCP
recycling endosome (GO:0055037)	5.11	2	SH3TC2, FIG4
intrinsic component of mitochondrial membrane (GO:0098573)	5.95	2	MFN2, GDAP1
dendrite (GO:0030425)	3.92	2	MTMR2, SPG11
intrinsic component of mitochondrial outer membrane (GO:0031306)	6.71	2	MFN2, GDAP1
intrinsic component of organelle membrane (GO:0031300)	4.8	2	MFN2, GDAP1
cilium (GO:0005929)	3.89	2	HK1, TRPV4
synapse (GO:0045202)	3.58	2	DNM2, SPG11
microtubule associated complex (GO:0005875)	4.79	2	DYNC1H1, KIF1B
Z disc (GO:0030018)	5.11	2	HSPB1, JPH1
synaptic membrane (GO:0097060)	4.22	2	DNM2, MTMR2
endocytic vesicle membrane (GO:0030666)	4.82	2	RAB7A, DNM2
extracellular space (GO:0005615)	2.63	2	HSPB1, YARS
axon cytoplasm (GO:1904115)	6.28	2	NEFL, KIF1B
Golgi apparatus part (GO:0044431)	3.0	2	FIG4, DNM2
secretory granule (GO:0030141)	4.34	2	RAB7A, GARS
late endosome membrane (GO:0031902)	5.16	2	RAB7A, FIG4
early endosome membrane (GO:0031901)	5.06	2	FIG4, MTMR2
membrane region (GO:0098589)	3.95	2	DNM2, HK1
cell projection cytoplasm (GO:0032838)	5.89	2	NEFL, KIF1B
leading edge membrane (GO:0031256)	4.9	2	DNM2, TRPV4
cytoplasmic region (GO:0099568)	4.51	2	NEFL, KIF1B
cell projection membrane (GO:0031253)	4.11	2	DNM2, TRPV4
neurofilament (GO:0005883)	7.61	2	NEFL, NEFH
transferase complex (GO:1990234)	3.32	2	DHTKD1, PRPS1
proteasome complex (GO:0000502)	5.6	2	HSPB1, VCP
ruffle membrane (GO:0032587)	5.42	2	DNM2, TRPV4
phagocytic vesicle membrane (GO:0030670)	5.71	2	RAB7A, DNM2
cell (GO:0005623)	5.22	2	AIFM1, HK1
Golgi membrane (GO:0000139)	3.28	2	FIG4, DNM2
contractile fiber part (GO:0044449)	4.53	2	HSPB1, JPH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytoplasm (GO:0005737)	-	1.01	0.006	VCP, PLEKHG5, MARS, LRSAM1, GARS, AARS, NEFH, FGD4, DNM2, HARS, PRX, HSPB1, LMNA, LITAF, IGHMBP2, YARS, TRIM2, MORC2, SPG11, KARS, NDRG1, NEFL, MTMR2, EGR2, HSPB8
organelle membrane (GO:0031090)	-	1.97	0.01	GJB1, MFN2, MARS, FIG4, EGR2, AIFM1, KIF1B, DNM2, TRPV4, VCP, HARS, MED25, HSPB1, LMNA, LITAF, YARS, DYNC1H1, HK1, SBF2, TRIM2, SPG11, JPH1, NDRG1, NEFL, MTMR2, COX6A1, NAGLU, SURF1, RAB7A
cytoplasmic vesicle (GO:0031410)	-	2.87	0.046	MFN2, DNM2, TRPV4, VCP, GJB1, PLEKHG5, NEFL, MTMR2, GARS, PRX, DYNC1H1, EGR2, RAB7A, SPG11, SH3TC2, KIF1B
cytosol (GO:0005829)	-	1.68	0.0	PRPS1, VCP, PLEKHG5, MFN2, MARS, AARS, AIFM1, FGD4, DNM2, HARS, HSPB1, LMNA, YARS, DYNC1H1, HK1, MORC2, SPG11, KARS, NDRG1, NEFL, MTMR2, GARS
cell projection part (GO:0044463)	-	2.97	0.004	DNM2, TRPV4, VCP, DYNC1H1, MTMR2, NEFL, HK1, MED25, EGR2, PRX, NDRG1, LRSAM1, HSPB1, IGHMBP2, LMNA, TRIM2, AIFM1, KIF1B
neurofilament (GO:0005883)	-	7.61	0.032	NEFL, NEFH
neuron part (GO:0097458)	-	2.64	0.021	DNM2, TRPV4, VCP, DYNC1H1, NEFL, MTMR2, EGR2, PRX, NDRG1, LRSAM1, HSPB1, IGHMBP2, LMNA, TRIM2, RAB7A, MPZ, AIFM1, NEFH, KIF1B
cytoplasmic part (GO:0044444)	-	0.82	0.0	VCP, PRPS1, GJB1, PLEKHG5, MFN2, MARS, FIG4, GARS, AARS, AIFM1, MORC2, FGD4, DNM2, TRPV4, GDAP1, HARS, HSPB1, KIF1B, LMNA, PDK3, LITAF, YARS, DYNC1H1, HK1, SBF2, NEFH, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, NEFL, MTMR2, COX6A1, NAGLU, SURF1, RAB7A
vacuolar part (GO:0044437)	-	3.26	0.046	SBF2, LITAF, MTMR2, NAGLU, RAB7A, SPG11
mitochondrial part (GO:0044429)	-	2.92	0.039	DNM2, YARS, KARS, GDAP1, MFN2, HK1, COX6A1, EGR2, SURF1, HSPB1, GARS, LMNA, RAB7A, AIFM1, PDK3
intracellular part (GO:0044424)	-	0.28	0.004	PRPS1, COX6A1, GDAP1, PLEKHG5, MFN2, MARS, LRSAM1, NAGLU, AARS, AIFM1, MORC2, FGD4, SBF2, TRPV4, VCP, HARS, PRX, MED25, HSPB1, KIF1B, LMNA, PDK3, LITAF, IGHMBP2, SBF1, YARS, DYNC1H1, HK1, DNM2, TRIM2, NEFH, SPG11, DHTKD1, SH3TC2, JPH1, KARS, NDRG1, GJB1, NEFL, MTMR2, FIG4, EGR2, SURF1, HSPB8, RAB7A, GARS
cell projection (GO:0042995)	-	2.47	0.0	VCP, PLEKHG5, LRSAM1, MPZ, AIFM1, KIF1B, DNM2, TRPV4, HARS, MED25, FGD4, LMNA, IGHMBP2, SBF1, DYNC1H1, HK1, TRIM2, NEFH, KARS, NDRG1, NEFL, MTMR2, EGR2, RAB7A
microtubule (GO:0005874)	-	3.81	0.016	DNM2, TRPV4, VCP, DYNC1H1, EGR2, NDRG1, HSPB1, LMNA, RAB7A, KIF1B