Disease table of PRIMARY CILIARY DYSKINESIA OMIM ID: PS244400

Gene-disease associations table

Gene	Associated with PRIMARY CILIARY DYSKINESIA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CCDC65	OMIM	HGNC link	12q13.12	1	PS244400
DNAH11	ClinVar, OMIM, HUMSAVAR	HGNC link	7p15.3	1	PS244400
RSPH4A	ClinVar, OMIM, HUMSAVAR	HGNC link	6q22.1	1	PS244400
CCDC40	ClinVar, OMIM	HGNC link	17q25.3	1	PS244400
ZMYND10	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	1	PS244400
DNAAF1	ClinVar, OMIM, HUMSAVAR	HGNC link	16q24.1	1	PS244400
DYX1C1	ClinVar, OMIM	HGNC link	15q21.3	2	127700, PS244400
DNAAF3	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.42	1	PS244400
DNAAF2	ClinVar, OMIM	HGNC link	14q21.3	1	PS244400
HYDIN	ClinVar, OMIM	HGNC link	16q22.2	1	PS244400
DNAI1	ClinVar, OMIM, HUMSAVAR	HGNC link	9p13.3	1	PS244400
CCDC103	ClinVar, OMIM, HUMSAVAR	HGNC link	17q21.31	1	PS244400
RSPH9	ClinVar, OMIM	HGNC link	6p21.1	1	PS244400
RSPH3	ClinVar, OMIM	HGNC link	6q25.3	1	PS244400
RSPH1	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.3	1	PS244400
DNAAF5	ClinVar, OMIM, HUMSAVAR	HGNC link	7p22.3	1	PS244400
DRC1	ClinVar, OMIM	HGNC link	2p23.3	1	PS244400
CCDC39	ClinVar, OMIM	HGNC link	3q26.33	1	PS244400
CENPF	ClinVar, OMIM	HGNC link	1q41	1	PS244400
LRRC6	ClinVar, OMIM, HUMSAVAR	HGNC link	8q24.22	1	PS244400
SPAG1	ClinVar, OMIM	HGNC link	8q22.2	2	PS600513, PS244400
DNAI2	ClinVar, OMIM	HGNC link	17q25.1	1	PS244400
MCIDAS	ClinVar	HGNC link	5q11.2	1	PS244400
ARMC4	ClinVar, OMIM, HUMSAVAR	HGNC link	10p12.1	1	PS244400
C21orf59	ClinVar, OMIM	HGNC link	21q22.11	1	PS244400
DNAH1	ClinVar	HGNC link	3p21.1	1	PS244400
DNAH5	ClinVar, OMIM, HUMSAVAR	HGNC link	5p15.2	1	PS244400
CCDC114	ClinVar, OMIM	HGNC link	19q13.33	1	PS244400
NME8	ClinVar, OMIM	HGNC link	7p14.1	1	PS244400
GAS8	ClinVar, OMIM	HGNC link	16q24.3	1	PS244400
CCDC151	ClinVar, OMIM	HGNC link	19p13.2	1	PS244400
CCNO	ClinVar, OMIM, HUMSAVAR	HGNC link	5q11.2	1	PS244400
DNAH8	ClinVar	HGNC link	6p21.2	1	PS244400
DNAL1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q24.3	1	PS244400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
5q11.2	2	MCIDAS, CCNO

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
16q24	2	GAS8, DNAAF1
5q11	2	MCIDAS, CCNO
21q22	2	C21orf59, RSPH1
17q25	2	CCDC40, DNAI2
19q13	2	DNAAF3, CCDC114
3p21	2	ZMYND10, DNAH1
6p21	2	DNAH8, RSPH9

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	3	CCDC40, DNAI2, CCDC103
5q1	2	MCIDAS, CCNO
6p2	2	DNAH8, RSPH9
6q2	2	RSPH4A, RSPH3
3p2	2	ZMYND10, DNAH1
16q2	3	GAS8, HYDIN, DNAAF1
7p1	2	DNAH11, NME8
19q1	2	DNAAF3, CCDC114
8q2	2	SPAG1, LRRC6
14q2	2	DNAL1, DNAAF2
21q2	2	C21orf59, RSPH1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
14q	2	DNAL1, DNAAF2
6q	2	RSPH4A, RSPH3
21q	2	C21orf59, RSPH1
3p	2	ZMYND10, DNAH1
19q	2	DNAAF3, CCDC114
6p	2	DNAH8, RSPH9
7p	3	DNAH11, NME8, DNAAF5
8q	2	SPAG1, LRRC6
16q	3	GAS8, HYDIN, DNAAF1
17q	3	CCDC40, DNAI2, CCDC103
5q	2	MCIDAS, CCNO

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
14	2	DNAL1, DNAAF2
17	3	CCDC40, DNAI2, CCDC103
16	3	GAS8, HYDIN, DNAAF1
19	3	DNAAF3, CCDC114, CCDC151
3	3	ZMYND10, CCDC39, DNAH1
5	3	MCIDAS, DNAH5, CCNO
7	3	DNAH11, NME8, DNAAF5
6	4	DNAH8, RSPH9, RSPH4A, RSPH3
8	2	SPAG1, LRRC6
21	2	C21orf59, RSPH1

Transcription Factors (TF) annotation from TRRUST

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CCDC40	DNAAF2	No	1	APP
CCDC40	RSPH3	No	1	APP
CCDC40	C21orf59	No	1	APP
CCDC40	NME8	No	1	APP
DYX1C1	CCDC151	No	1	KDM1A
DNAAF2	RSPH3	No	1	APP
DNAAF2	C21orf59	No	1	APP
DNAAF2	NME8	No	1	APP
HYDIN	SPAG1	No	1	UBC
DNAI1	DNAI2	No	1	SQSTM1
CCDC103	CCDC114	No	1	HGS
RSPH9	CENPF	No	1	HECW2
RSPH3	C21orf59	No	1	APP
RSPH3	NME8	No	1	APP
RSPH3	CCNO	No	1	HSPB1
DNAAF5	DNAI2	Yes	0
DNAAF5	GAS8	No	1	CIAO1
CENPF	SPAG1	No	1	CEP152
SPAG1	CCNO	No	1	PCNA
C21orf59	NME8	No	1	APP
CCDC114	CCDC151	Yes	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
DNAH11	DNAI1	Yes	binding	5	CCDC114, DNAL4, DNAI2, DYNLL1, TCTE3
DNAH11	CENPF	No	-	6	CLASP2, CENPE, PAFAH1B1, MAPRE1, CLASP1, KIF18A
DNAH11	DNAI2	Yes	binding	7	DYNLL2, TCTE3, DNAI1, DNAL4, CCDC114, DYNLT1, DYNLL1
DNAH11	DNAH1	No	-	11	DYNLL2, DNAI2, PAFAH1B1, WDR67, DNAI1, DCTN1, DNAL4, CCDC114, DYNLT1, DYNLL1, DYNC2LI1
DNAH11	DNAH5	No	-	10	DYNLL2, DNAI2, PAFAH1B1, WDR67, DNAI1, DCTN1, DNAL4, CCDC114, DYNLL1, DYNC2LI1
DNAH11	CCDC114	Yes	binding	4	DNAI1, DNAI2, DYNLT1, DYNLL1
DNAH11	CCDC151	No	-	1	CCDC114
DNAH11	DNAH8	No	-	10	DYNLL2, DNAI2, PAFAH1B1, WDR67, DYNLL1, DCTN1, DNAL4, CCDC114, DYNLT1, DYNC2LI1
ZMYND10	LRRC6	Yes	binding	0
DYX1C1	DNAAF2	Yes	binding	2	HSP90AA1, HSP90AB1
DYX1C1	SPAG1	No	-	3	TRAP1, HSP90AA1, HSP90AB1
DNAAF2	SPAG1	No	-	2	HSP90AA1, HSP90AB1
DNAI1	DNAI2	Yes	binding	13	DNAH1, DYNLRB2, TCTE3, DYNLL1, DNAH3, CCDC114, DNAH11, CCDC63, DNAL4, DNAH7, DNALI1, DNAH9, DNAH5
DNAI1	DNAH1	Yes	binding	9	DNAI2, DYNLRB2, DYNLL1, DNAH3, DNAL4, CCDC114, DNAH7, DNALI1, DNAH5
DNAI1	DNAH5	Yes	binding	7	DNAH1, DYNLL1, DNAH3, DNAL4, CCDC114, DNALI1, DNAI2
DNAI1	CCDC114	Yes	binding	9	DNAH1, DYNLRB2, DYNLL1, DNAH3, DNAH11, DNAH7, DNALI1, DNAI2, DNAH5
DNAI1	CCDC151	No	-	1	CCDC114
DNAI1	DNAH8	No	-	10	DNAH1, DYNLRB2, DYNLL1, DNAH3, DNAL4, CCDC114, DNAH7, DNALI1, DNAI2, DNAH5
CENPF	C21orf59	No	-	1	UBC
CENPF	DNAH1	No	-	2	PAFAH1B1, CLIP1
CENPF	DNAH5	No	-	2	PAFAH1B1, CLIP1
CENPF	CCNO	No	-	1	CDC20
CENPF	DNAH8	No	-	2	PAFAH1B1, CLIP1
DNAI2	DNAH1	Yes	binding	22	DYNLL2, DYNC1LI1, DNAH8, DYNLRB2, DYNLL1, DNAH3, CCDC114, DNAL4, DNAH17, TPR, DYNLT1, DYNC1LI2, DYNC1H1, DYNLRB1, SNX4, DNAH5, DYNC1I1, DYNLT3, DNAH2, DNAH7, DNALI1, DNAI1
DNAI2	DNAH5	Yes	binding	9	DYNLL2, DNAH1, DNAI1, DNAH3, DNAL4, DNAH8, CCDC114, DNALI1, DYNLL1
DNAI2	CCDC114	Yes	binding	21	DYNC1LI2, DNAH1, DNAH17, DYNLRB2, DYNC1H1, DNAH3, DYNLL1, DYNLRB1, DNAH8, DNAH11, DYNC1LI1, DNALI1, DYNLT3, DNAH7, DNAH2, SNX4, TPR, DYNLT1, DNAH5, DNAI1, DYNC1I1
DNAI2	CCDC151	No	-	1	CCDC114
DNAI2	DNAH8	Yes	binding	21	DYNC1LI2, DYNLL2, DNAH1, DNAH17, DYNLRB2, DYNC1H1, DNAH3, DYNLL1, DYNLRB1, CCDC114, DNAH2, DNALI1, DYNLT3, DNAL4, DNAH7, SNX4, TPR, DYNC1LI1, DYNLT1, DNAH5, DYNC1I1
DNAH1	DNAH5	Yes	binding	19	DNAH14, DNAI2, CLIP1, DCTN6, DCTN3, DCTN1, DNAI1, DNAH3, DYNLL2, DNAH8, DNAL4, DYNC2LI1, DNALI1, DCTN2, WDR67, PAFAH1B1, DYNLL1, DNAH6, CCDC114
DNAH1	CCDC114	Yes	binding	20	DNAI2, DNAH17, DYNC1LI2, DYNC1H1, DYNLRB1, DNAI1, DNAH3, DYNLT3, DNAH2, DNALI1, DNAH8, DNAH7, SNX4, TPR, DYNC1LI1, DYNLT1, DNAH5, DYNLL1, DYNC1I1, DYNLRB2
DNAH1	CCDC151	No	-	1	CCDC114
DNAH1	DNAH8	Yes	binding	30	DYNLL2, DYNC1LI1, DNAH3, DYNLT3, DYNLRB2, DNAI2, DCTN6, DYNLL1, DCTN1, DNAL4, DYNC1H1, CCDC114, CLIP1, TPR, DYNLT1, DYNC2LI1, DNAH17, DYNC1LI2, DCTN3, WDR67, DYNLRB1, PAFAH1B1, SNX4, DNAH5, DYNC1I1, DCTN2, DNAH2, DNAH7, DNALI1, DNAH6
DNAH5	CCDC114	Yes	binding	7	DNAH1, DNAI1, DNAH3, DNAH8, DNALI1, DNAI2, DYNLL1
DNAH5	CCDC151	No	-	1	CCDC114
DNAH5	DNAH8	Yes	binding	18	DYNLL2, DNAH1, CLIP1, DCTN6, DCTN3, DCTN1, DYNLL1, DNAH3, DNAL4, CCDC114, PAFAH1B1, DYNC1I2, DNAH6, DNALI1, DCTN2, DNAI2, WDR67, DYNC2LI1
CCDC114	CCDC151	Yes	binding	0
CCDC114	DNAH8	Yes	binding	19	DNAI2, SNX4, DYNC1LI2, DYNC1H1, DYNLRB1, DYNLL1, DNAH3, DNAH2, DNALI1, DYNLT3, DNAH7, DNAH17, TPR, DYNC1LI1, DNAH1, DYNLT1, DNAH5, DYNC1I1, DYNLRB2
GAS8	DNAH8	No	-	1	MYH14
CCDC151	DNAH8	No	-	1	CCDC114

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Huntington's disease	hsa05016	5.17	7	DNAH1, DNAI1, DNAL1, DNAH11, DNAH8, DNAI2, DNAH5

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Human Diseases	NEW	1.54	0.002	DNAI2, DNAI1, DNAL1, DNAH11, DNAH8, DNAH1, DNAH5
Neurodegenerative diseases	NEW	4.27	0.0	DNAH1, DNAI1, DNAL1, DNAH11, DNAH8, DNAI2, DNAH5
Huntington's disease (hsa05016)	-	5.17	0.0	DNAH1, DNAI1, DNAL1, DNAH11, DNAH8, DNAI2, DNAH5

REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	23	ZMYND10, RSPH3, LRRC6, DNAI2, DNAI1, DNAAF2, CCDC103, CENPF, CCDC114, NME8, DNAAF5, GAS8, RSPH1, MCIDAS, DYX1C1, RSPH9, DNAH1, DNAH5, SPAG1, DNAH8, DNAH11, DNAAF1, CCDC151
protein binding (GO:0005515)	0.46	18	ZMYND10, GAS8, DNAI2, MCIDAS, DNAI1, CCDC114, CCDC103, CENPF, DYX1C1, RSPH9, NME8, RSPH3, RSPH1, DNAAF1, CCDC151, DNAAF5, LRRC6, DNAAF2
catalytic activity (GO:0003824)	1.05	9	DNAH1, SPAG1, DNAI1, DNAH11, DNAH8, NME8, DNAI2, CCNO, DNAH5
hydrolase activity (GO:0016787)	1.9	8	DNAH1, SPAG1, DNAI1, DNAH11, DNAH8, DNAI2, CCNO, DNAH5
pyrophosphatase activity (GO:0016462)	3.04	6	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	6	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
motor activity (GO:0003774)	4.81	6	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	6	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
nucleoside-triphosphatase activity (GO:0017111)	3.09	6	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
microtubule motor activity (GO:0003777)	5.34	5	DNAI2, DNAH8, DNAH1, DNAH5, DNAH11
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	5	DNAH5, SPAG1, DNAH8, DNAH1, DNAH11
organic cyclic compound binding (GO:0097159)	1.05	5	DNAH5, SPAG1, DNAH8, DNAH1, DNAH11
nucleotide binding (GO:0000166)	1.96	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
small molecule binding (GO:0036094)	1.89	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
carbohydrate derivative binding (GO:0097367)	2.03	5	DNAH5, SPAG1, DNAH8, DNAH1, DNAH11
purine ribonucleoside binding (GO:0032550)	2.22	5	DNAH5, SPAG1, DNAH8, DNAH1, DNAH11
ribonucleotide binding (GO:0032553)	2.19	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
purine nucleoside binding (GO:0001883)	2.22	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
ribonucleoside binding (GO:0032549)	2.22	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
purine ribonucleotide binding (GO:0032555)	2.2	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
purine nucleotide binding (GO:0017076)	2.19	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
heterocyclic compound binding (GO:1901363)	1.06	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
nucleoside phosphate binding (GO:1901265)	1.96	5	DNAH5, DNAH1, DNAH8, SPAG1, DNAH11
nucleoside binding (GO:0001882)	2.21	5	DNAH1, DNAH8, DNAH5, SPAG1, DNAH11
adenyl ribonucleotide binding (GO:0032559)	2.41	4	DNAH5, DNAH8, DNAH1, DNAH11
ATP binding (GO:0005524)	2.43	4	DNAH5, DNAH8, DNAH1, DNAH11
ATPase activity (GO:0016887)	3.65	4	DNAH5, DNAH8, DNAH1, DNAH11
adenyl nucleotide binding (GO:0030554)	2.4	4	DNAH5, DNAH8, DNAH1, DNAH11
dynein binding (GO:0045502)	6.44	3	CENPF, DNAAF5, DNAAF1
identical protein binding (GO:0042802)	2.63	3	CENPF, MCIDAS, CCDC103
protein dimerization activity (GO:0046983)	2.72	2	CENPF, CCDC103
protein homodimerization activity (GO:0042803)	3.16	2	CENPF, CCDC103

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	-	3.03	0.025	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
dynein binding (GO:0045502)	-	6.44	0.017	CENPF, DNAAF1
nucleoside-triphosphatase activity (GO:0017111)	-	3.09	0.018	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
hydrolase activity, acting on acid anhydrides (GO:0016817)	-	3.03	0.026	DNAH1, DNAI1, DNAH11, DNAH8, DNAI2, DNAH5
pyrophosphatase activity (GO:0016462)	-	3.04	0.024	DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, DNAH5
motor activity (GO:0003774)	-	4.81	0.0	DNAH1, DNAI1, DNAH11, DNAH8, DNAI2, DNAH5
microtubule motor activity (GO:0003777)	-	5.34	0.0	DNAH5, DNAI2, DNAH8, DNAH1, DNAH11

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	31	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, DNAI2, DNAI1, DNAAF2, CCDC39, CENPF, CCDC114, MCIDAS, DNAAF5, GAS8, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, DNAH8, DNAH11, CCNO, CCDC40, HYDIN, DRC1, CCDC151, DNAAF3
single-organism cellular process (GO:0044763)	0.65	31	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, CCDC114, DNAI2, DNAI1, CCNO, CCDC39, CENPF, DNAAF2, MCIDAS, DNAAF5, GAS8, RSPH1, NME8, DYX1C1, HYDIN, DNAH1, DNAH5, DNAAF1, ARMC4, CCDC151, DNAH8, DNAH11, CCDC40, RSPH9, DRC1, SPAG1, DNAAF3
single-organism process (GO:0044699)	0.48	31	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, DNAI2, DNAI1, DNAAF2, CCDC39, CENPF, CCDC114, MCIDAS, DNAAF5, GAS8, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, DNAH8, DNAH11, CCNO, CCDC40, HYDIN, DRC1, CCDC151, DNAAF3
single-organism developmental process (GO:0044767)	1.49	29	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, DNAI2, DNAI1, CCDC114, CCDC39, CENPF, DNAAF2, MCIDAS, DNAAF5, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, DNAH11, CCNO, CCDC40, HYDIN, DRC1, CCDC151, DNAAF3
developmental process (GO:0032502)	1.36	29	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, DNAI2, DNAI1, CCDC114, CCDC39, CENPF, DNAAF2, MCIDAS, DNAAF5, RSPH1, NME8, DYX1C1, HYDIN, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, DNAH11, CCNO, CCDC40, RSPH9, DRC1, CCDC151, DNAAF3
cellular component organization (GO:0016043)	1.24	28	RSPH4A, ZMYND10, CCDC39, C21orf59, LRRC6, DNAI2, DNAI1, CCDC114, CCDC103, CENPF, DNAAF2, MCIDAS, DNAAF5, RSPH1, NME8, DYX1C1, HYDIN, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, CCNO, CCDC40, RSPH9, DRC1, CCDC151, DNAAF3
cellular component organization or biogenesis (GO:0071840)	1.22	28	RSPH4A, ZMYND10, CCDC39, C21orf59, LRRC6, DNAI2, DNAI1, CCDC114, CCDC103, CENPF, DNAAF2, MCIDAS, DNAAF5, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, CCNO, CCDC40, HYDIN, DRC1, CCDC151, DNAAF3
cellular component assembly (GO:0022607)	2.14	27	RSPH4A, ZMYND10, CCDC39, LRRC6, DNAI2, DNAI1, CCDC114, CCDC103, CENPF, DNAAF2, MCIDAS, DNAAF5, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, CCDC151, CCNO, CCDC40, HYDIN, DRC1, SPAG1, DNAAF3
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	26	RSPH4A, ZMYND10, CCDC39, LRRC6, DNAI2, DNAI1, CCDC114, CCDC103, DNAAF2, MCIDAS, DNAAF5, RSPH1, NME8, DYX1C1, HYDIN, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, CCNO, CCDC40, RSPH9, DRC1, CCDC151, DNAAF3
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	26	RSPH4A, ZMYND10, CCDC39, LRRC6, DNAI2, DNAI1, DNAAF2, CCDC103, CCDC114, MCIDAS, DNAAF5, RSPH1, NME8, DYX1C1, HYDIN, DNAH1, DNAH5, DNAAF1, ARMC4, CCDC151, CCNO, CCDC40, RSPH9, DRC1, SPAG1, DNAAF3
movement of cell or subcellular component (GO:0006928)	2.61	23	RSPH4A, DNAH8, CCDC103, LRRC6, DNAI2, DNAI1, CCDC114, CCDC39, DNAAF2, NME8, DNAAF5, GAS8, DYX1C1, HYDIN, DNAH1, DNAH5, DNAAF1, ARMC4, DNAH11, CCDC40, RSPH9, DRC1, CCDC151
microtubule-based process (GO:0007017)	3.54	21	RSPH4A, CCDC39, DNAI2, MCIDAS, ARMC4, CCDC151, DNAI1, CCDC114, DNAH11, HYDIN, DNAH8, DYX1C1, DNAH1, RSPH9, CCDC103, CCDC40, RSPH1, DNAAF1, DNAH5, DNAAF5, LRRC6
protein complex subunit organization (GO:0071822)	2.6	20	DYX1C1, DNAAF3, DNAI2, ARMC4, CCDC151, SPAG1, DNAI1, ZMYND10, CCDC39, CENPF, DRC1, CCDC114, CCDC103, CCDC40, DNAH1, DNAAF5, DNAH5, DNAAF1, LRRC6, DNAAF2
cell projection organization (GO:0030030)	3.14	20	RSPH4A, CCDC39, DNAI2, CCDC40, C21orf59, CCDC151, DNAI1, RSPH9, CCDC103, MCIDAS, ARMC4, ZMYND10, DNAAF5, LRRC6, NME8, RSPH1, DNAAF1, DNAH5, CCNO, DNAAF3
protein complex assembly (GO:0006461)	2.78	20	DYX1C1, DNAAF3, DNAI2, ARMC4, CCDC151, SPAG1, DNAI1, ZMYND10, CCDC39, CENPF, DRC1, CCDC114, CCDC103, CCDC40, DNAH1, DNAAF5, DNAH5, DNAAF1, LRRC6, DNAAF2
macromolecular complex assembly (GO:0065003)	2.55	20	DYX1C1, ZMYND10, DNAH1, ARMC4, CCDC151, DNAI1, CCDC114, CCDC39, DRC1, CENPF, SPAG1, DNAAF2, CCDC103, CCDC40, DNAI2, DNAAF5, DNAH5, DNAAF1, LRRC6, DNAAF3
macromolecular complex subunit organization (GO:0043933)	2.14	20	DYX1C1, DNAAF3, DNAI2, ARMC4, CCDC151, DNAI1, ZMYND10, CCDC39, DRC1, CENPF, SPAG1, CCDC114, CCDC103, CCDC40, DNAH1, DNAAF5, DNAH5, DNAAF1, LRRC6, DNAAF2
cellular macromolecular complex assembly (GO:0034622)	3.18	20	DYX1C1, DNAAF3, DNAI2, ARMC4, SPAG1, DNAI1, ZMYND10, CCDC39, CENPF, DRC1, CCDC114, LRRC6, CCDC103, CCDC40, DNAH1, DNAAF5, DNAH5, DNAAF1, CCDC151, DNAAF2
cellular protein complex assembly (GO:0043623)	3.9	20	ZMYND10, DNAI2, ARMC4, SPAG1, DNAI1, DNAAF2, CCDC103, CENPF, DRC1, DYX1C1, DNAAF3, CCDC39, CCDC40, LRRC6, DNAH1, DNAAF5, DNAH5, DNAAF1, CCDC151, CCDC114
microtubule-based movement (GO:0007018)	4.39	19	DYX1C1, RSPH4A, CCDC39, DNAH1, ARMC4, CCDC151, DNAI1, DNAH8, DNAH11, HYDIN, CCDC114, RSPH9, CCDC103, CCDC40, DNAI2, DNAAF5, DNAH5, DNAAF1, LRRC6
axonemal dynein complex assembly (GO:0070286)	6.64	19	ZMYND10, DNAI2, ARMC4, CCDC151, SPAG1, DNAI1, DNAAF2, CCDC39, DRC1, DYX1C1, CCDC114, CCDC103, CCDC40, DNAH1, DNAAF5, DNAH5, DNAAF1, LRRC6, DNAAF3
cilium movement (GO:0003341)	6.12	18	RSPH4A, CCDC39, DNAI2, ARMC4, CCDC151, DNAI1, CCDC114, DNAH11, HYDIN, DYX1C1, RSPH9, CCDC103, CCDC40, DNAH1, DNAAF1, DNAH5, DNAAF5, LRRC6
organelle organization (GO:0006996)	2.02	16	RSPH4A, DNAI2, CCDC40, DNAAF2, CCDC39, MCIDAS, CENPF, ZMYND10, RSPH9, DNAAF3, NME8, RSPH1, CCNO, DNAH5, DNAAF1, LRRC6
single-organism organelle organization (GO:1902589)	2.68	15	RSPH4A, RSPH1, CCDC40, DNAAF2, CCDC39, MCIDAS, ZMYND10, RSPH9, DNAAF3, NME8, DNAI2, CCNO, DNAH5, DNAAF1, LRRC6
multicellular organismal process (GO:0032501)	1.45	15	DNAI2, CCDC40, ARMC4, CCDC151, DNAI1, CCDC39, CENPF, DRC1, DYX1C1, HYDIN, CCDC103, NME8, DNAAF1, DNAH5, DNAH11
single-multicellular organism process (GO:0044707)	1.78	15	CCDC39, DNAI2, CCDC40, ARMC4, CCDC151, DNAI1, DNAH11, CENPF, DYX1C1, HYDIN, CCDC103, NME8, DNAAF1, DNAH5, DRC1
cell projection assembly (GO:0030031)	4.19	14	RSPH4A, DNAI2, CCDC40, CCDC39, MCIDAS, ZMYND10, RSPH9, DNAAF3, NME8, RSPH1, CCNO, DNAH5, DNAAF1, LRRC6
anatomical structure development (GO:0048856)	1.58	14	RSPH1, CCDC40, ARMC4, DNAI1, DNAH11, CENPF, DYX1C1, HYDIN, CCDC39, NME8, DNAAF1, DNAH5, DRC1, LRRC6
locomotion (GO:0040011)	2.91	13	GAS8, DNAH1, CCDC40, DNAI1, DYX1C1, DNAH11, DNAH8, CCDC39, NME8, DRC1, DNAH5, LRRC6, DNAAF2
organelle assembly (GO:0070925)	3.75	13	DNAI2, CCDC40, CCDC39, MCIDAS, CENPF, ZMYND10, RSPH9, DNAAF3, NME8, CCNO, DNAH5, DNAAF1, LRRC6
cell motility (GO:0048870)	3.02	13	GAS8, DNAH1, CCDC40, DNAI1, DNAAF2, DNAH11, DNAH8, DYX1C1, CCDC39, NME8, DRC1, DNAH5, LRRC6
pattern specification process (GO:0007389)	3.79	12	DNAI2, ARMC4, CCDC151, DNAI1, DNAH11, CCDC103, DYX1C1, CCDC39, CCDC40, DNAAF1, DNAH5, DRC1
cilium assembly (GO:0042384)	4.77	12	DNAI2, CCDC40, CCDC39, MCIDAS, ZMYND10, RSPH9, DNAAF3, NME8, CCNO, DNAH5, DNAAF1, LRRC6
determination of left/right symmetry (GO:0007368)	5.38	12	DNAI2, ARMC4, CCDC151, DNAI1, CCDC39, CCDC103, DYX1C1, DNAH11, CCDC40, DNAAF1, DNAH5, DRC1
outer dynein arm assembly (GO:0036158)	7.24	12	ZMYND10, DNAI2, ARMC4, CCDC151, DNAI1, CCDC114, CCDC103, DYX1C1, DNAAF1, DNAH5, DNAAF5, LRRC6
regulation of cellular process (GO:0050794)	0.5	12	GAS8, NME8, ARMC4, DNAAF2, DNAH11, MCIDAS, CENPF, DYX1C1, CCDC39, CCDC40, DNAAF1, CCDC151
biological regulation (GO:0065007)	0.39	12	GAS8, NME8, ARMC4, DYX1C1, DNAH11, MCIDAS, CENPF, DNAAF2, CCDC39, CCDC40, DNAAF1, CCDC151
determination of bilateral symmetry (GO:0009855)	5.37	12	DNAI2, ARMC4, CCDC151, DNAI1, DNAH11, CCDC103, DYX1C1, CCDC39, CCDC40, DRC1, DNAH5, DNAAF1
specification of symmetry (GO:0009799)	5.36	12	DNAI2, ARMC4, CCDC151, DNAI1, CCDC39, CCDC103, DYX1C1, DNAH11, CCDC40, DNAAF1, DNAH5, DRC1
cilium organization (GO:0044782)	4.67	12	DNAI2, NME8, CCDC39, MCIDAS, ZMYND10, RSPH9, DNAAF3, CCDC40, DNAAF1, DNAH5, CCNO, LRRC6
regulation of biological process (GO:0050789)	0.45	12	GAS8, NME8, ARMC4, DYX1C1, DNAH11, MCIDAS, CENPF, DNAAF2, CCDC39, CCDC40, DNAAF1, CCDC151
animal organ development (GO:0048513)	2.53	11	ARMC4, DNAI1, DNAH11, CENPF, HYDIN, CCDC39, CCDC40, DNAAF1, DNAH5, DRC1, LRRC6
sperm motility (GO:0030317)	5.82	9	GAS8, DNAH1, CCDC40, DNAI1, DNAH11, CCDC39, NME8, DNAH5, LRRC6
inner dynein arm assembly (GO:0036159)	7.33	9	DNAH1, DYX1C1, CCDC39, ZMYND10, CCDC103, CCDC40, DNAAF1, DNAAF5, LRRC6
cellular developmental process (GO:0048869)	1.82	8	RSPH1, NME8, C21orf59, CENPF, HYDIN, MCIDAS, DNAAF1, CCNO
motile cilium assembly (GO:0044458)	7.02	8	MCIDAS, CCDC39, ZMYND10, RSPH9, DNAAF3, CCDC40, DNAAF1, LRRC6
epithelial cilium movement (GO:0003351)	6.78	7	DNAH1, DNAI1, CCDC39, CCDC103, CCDC40, DNAAF1, LRRC6
heart development (GO:0007507)	4.24	6	ARMC4, DNAI1, DNAH11, CCDC39, DRC1, DNAH5
regulation of cellular component movement (GO:0051270)	3.08	5	DNAH11, CCDC40, DNAAF1, CCDC39, ARMC4
regulation of cilium beat frequency (GO:0003356)	7.33	5	DNAH11, CCDC40, DNAAF1, CCDC39, ARMC4
anatomical structure morphogenesis (GO:0009653)	2.53	5	CCDC40, DNAAF1, C21orf59, CCDC39, CCDC103
response to stimulus (GO:0050896)	1.22	5	CENPF, DNAAF2, DNAH1, CCNO, NME8
epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.65	5	CCDC40, DNAAF1, CCDC39, LRRC6, CCDC103
regulation of microtubule-based movement (GO:0060632)	6.78	5	DNAH11, CCDC40, DNAAF1, CCDC39, ARMC4
cilium or flagellum-dependent cell motility (GO:0001539)	7.33	5	DRC1, DNAH8, DNAH1, DNAAF2, CCDC39
system development (GO:0048731)	2.92	5	CENPF, DYX1C1, HYDIN, LRRC6, ARMC4
regulation of microtubule-based process (GO:0032886)	4.79	5	DNAH11, CCDC40, DNAAF1, CCDC39, ARMC4
regulation of localization (GO:0032879)	1.94	5	DNAH11, CCDC40, DNAAF1, CCDC39, ARMC4
regulation of cilium movement (GO:0003352)	7.24	5	DNAH11, CCDC40, DNAAF1, CCDC39, ARMC4
cell differentiation (GO:0030154)	2.14	4	CENPF, CCNO, MCIDAS, NME8
cellular nitrogen compound metabolic process (GO:0034641)	1.22	4	CENPF, CCNO, MCIDAS, NME8
nitrogen compound metabolic process (GO:0006807)	1.13	4	CENPF, CCNO, MCIDAS, NME8
determination of digestive tract left/right asymmetry (GO:0071907)	7.78	4	CCDC40, DNAAF1, CCDC39, CCDC103
organic cyclic compound metabolic process (GO:1901360)	1.26	4	CENPF, CCNO, MCIDAS, NME8
nucleobase-containing compound metabolic process (GO:0006139)	1.35	4	CENPF, CCNO, MCIDAS, NME8
heart looping (GO:0001947)	5.65	4	CCDC40, DNAAF1, CCDC39, CCDC103
organic substance metabolic process (GO:0071704)	0.63	4	CENPF, CCNO, MCIDAS, NME8
cell cycle (GO:0007049)	3.14	4	CENPF, CCNO, RSPH1, MCIDAS
tissue morphogenesis (GO:0048729)	3.87	4	CCDC40, DNAAF1, CCDC39, CCDC103
epithelial tube morphogenesis (GO:0060562)	5.12	4	CCDC40, DNAAF1, CCDC39, CCDC103
embryonic morphogenesis (GO:0048598)	3.72	4	CCDC40, DNAAF1, CCDC39, CCDC103
tube morphogenesis (GO:0035239)	4.35	4	CCDC40, DNAAF1, CCDC39, CCDC103
embryonic heart tube morphogenesis (GO:0003143)	5.57	4	CCDC40, DNAAF1, CCDC39, CCDC103
cellular aromatic compound metabolic process (GO:0006725)	1.3	4	CENPF, CCNO, MCIDAS, NME8
reproductive process (GO:0022414)	2.55	4	SPAG1, RSPH1, NME8, LRRC6
metabolic process (GO:0008152)	0.58	4	CENPF, CCNO, MCIDAS, NME8
response to chemical (GO:0042221)	1.98	4	CENPF, DNAAF2, CCNO, NME8
heterocycle metabolic process (GO:0046483)	1.31	4	CENPF, CCNO, MCIDAS, NME8
primary metabolic process (GO:0044238)	0.69	4	CENPF, CCNO, MCIDAS, NME8
single organism reproductive process (GO:0044702)	2.73	4	SPAG1, RSPH1, NME8, LRRC6
cellular metabolic process (GO:0044237)	0.69	4	CENPF, CCNO, MCIDAS, NME8
morphogenesis of an epithelium (GO:0002009)	4.08	4	CCDC40, DNAAF1, CCDC39, CCDC103
lung development (GO:0030324)	5.13	3	DNAAF1, CCDC40, CCDC39
regulation of primary metabolic process (GO:0080090)	1.08	3	CENPF, DYX1C1, MCIDAS
regulation of metabolic process (GO:0019222)	1.02	3	CENPF, DYX1C1, MCIDAS
regulation of response to stimulus (GO:0048583)	1.54	3	DYX1C1, DNAAF2, NME8
nucleic acid metabolic process (GO:0090304)	1.46	3	CENPF, CCNO, MCIDAS
cellular biosynthetic process (GO:0044249)	1.37	3	CENPF, MCIDAS, NME8
microtubule cytoskeleton organization (GO:0000226)	4.13	3	RSPH9, RSPH4A, RSPH1
organic cyclic compound biosynthetic process (GO:1901362)	1.66	3	CENPF, MCIDAS, NME8
multicellular organism development (GO:0007275)	2.54	3	CENPF, HYDIN, NME8
organic substance biosynthetic process (GO:1901576)	1.34	3	CENPF, MCIDAS, NME8
ventricular system development (GO:0021591)	7.02	3	CENPF, HYDIN, ARMC4
cellular macromolecule metabolic process (GO:0044260)	0.93	3	CENPF, CCNO, MCIDAS
axoneme assembly (GO:0035082)	6.68	3	RSPH1, RSPH4A, RSPH9
cilium-dependent cell motility (GO:0060285)	8.34	3	DNAAF2, DRC1, CCDC39
negative regulation of biological process (GO:0048519)	1.33	3	CENPF, GAS8, NME8
cytoskeleton organization (GO:0007010)	3.22	3	RSPH9, RSPH4A, RSPH1
heterocycle biosynthetic process (GO:0018130)	1.7	3	CENPF, MCIDAS, NME8
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	CENPF, DYX1C1, MCIDAS
regulation of cellular metabolic process (GO:0031323)	1.07	3	CENPF, DYX1C1, MCIDAS
biosynthetic process (GO:0009058)	1.32	3	CENPF, MCIDAS, NME8
determination of pancreatic left/right asymmetry (GO:0035469)	8.12	3	DNAAF1, CCDC40, CCDC39
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	3	CENPF, MCIDAS, NME8
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	3	CENPF, MCIDAS, NME8
determination of liver left/right asymmetry (GO:0071910)	7.94	3	DNAAF1, CCDC40, CCDC39
microtubule bundle formation (GO:0001578)	5.9	3	RSPH1, RSPH4A, RSPH9
macromolecule metabolic process (GO:0043170)	0.83	3	CENPF, CCNO, MCIDAS
aromatic compound biosynthetic process (GO:0019438)	1.7	3	CENPF, MCIDAS, NME8
negative regulation of cellular process (GO:0048523)	1.41	3	CENPF, GAS8, NME8
protein localization (GO:0008104)	2.36	2	CENPF, GAS8
multi-ciliated epithelial cell differentiation (GO:1903251)	8.34	2	CCNO, MCIDAS
regulation of organelle organization (GO:0033043)	2.72	2	CENPF, CCDC151
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	CENPF, MCIDAS
cell development (GO:0048468)	3.28	2	HYDIN, RSPH1
regulation of cellular component organization (GO:0051128)	2.01	2	CENPF, CCDC151
cellular localization (GO:0051641)	2.32	2	CENPF, GAS8
regulation of signaling (GO:0023051)	1.72	2	DYX1C1, NME8
localization (GO:0051179)	1.4	2	CENPF, GAS8
regulation of cell communication (GO:0010646)	1.73	2	DYX1C1, NME8
cell division (GO:0051301)	3.68	2	CENPF, CCNO
cellular response to stimulus (GO:0051716)	1.97	2	CCNO, NME8
regulation of signal transduction (GO:0009966)	1.84	2	DYX1C1, NME8
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	CENPF, MCIDAS
cellular component morphogenesis (GO:0032989)	3.5	2	DNAAF1, C21orf59
regulation of developmental process (GO:0050793)	2.1	2	CENPF, CCDC151
epithelial cell differentiation (GO:0030855)	3.98	2	CCNO, MCIDAS
macromolecule localization (GO:0033036)	2.34	2	CENPF, GAS8
regulation of gene expression (GO:0010468)	1.37	2	CENPF, MCIDAS
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	CENPF, MCIDAS
regulation of biosynthetic process (GO:0009889)	1.37	2	CENPF, MCIDAS
regulation of mitotic cell cycle (GO:0007346)	3.71	2	CENPF, MCIDAS
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	CENPF, MCIDAS
cellular macromolecule biosynthetic process (GO:0034645)	1.66	2	CENPF, MCIDAS
developmental process involved in reproduction (GO:0003006)	3.36	2	RSPH1, LRRC6
response to stress (GO:0006950)	1.8	2	CCNO, NME8
macromolecule biosynthetic process (GO:0009059)	1.61	2	CENPF, MCIDAS
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	CENPF, MCIDAS
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	CENPF, MCIDAS
cell part morphogenesis (GO:0032990)	3.99	2	DNAAF1, C21orf59
bacterial-type flagellum-dependent cell motility (GO:0071973)	9.04	2	DNAAF2, DRC1
archaeal or bacterial-type flagellum-dependent cell motility (GO:0097588)	9.04	2	DNAAF2, DRC1
response to oxygen-containing compound (GO:1901700)	2.57	2	DNAAF2, NME8
cell projection morphogenesis (GO:0048858)	4.05	2	DNAAF1, C21orf59
regulation of cell cycle (GO:0051726)	2.93	2	CENPF, MCIDAS
regulation of response to stress (GO:0080134)	2.53	2	DNAAF2, NME8
regulation of RNA metabolic process (GO:0051252)	1.52	2	CENPF, MCIDAS
response to drug (GO:0042493)	3.71	2	CENPF, CCNO
cilium movement involved in cell motility (GO:0060294)	8.12	2	DNAH1, RSPH9
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	CENPF, MCIDAS
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	CENPF, MCIDAS
cellular response to stress (GO:0033554)	2.51	2	CCNO, NME8
DNA metabolic process (GO:0006259)	3.09	2	CENPF, CCNO

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cellular component assembly (GO:0022607)	-	2.14	0.0	ZMYND10, RSPH4A, RSPH1, MCIDAS, ARMC4, DNAI2, CCDC114, CCDC103, CENPF, DRC1, DYX1C1, RSPH9, CCDC39, CCDC40, DNAAF3, HYDIN, DNAAF1, SPAG1, CCNO, LRRC6, DNAAF2
cell projection organization (GO:0030030)	-	3.14	0.0	RSPH4A, RSPH1, ARMC4, DNAI1, GAS8, CCDC103, HYDIN, ZMYND10, RSPH9, DNAAF3, MCIDAS, DNAI2, DNAAF1, CCNO, LRRC6
inner dynein arm assembly (GO:0036159)	-	7.33	0.0	LRRC6, ZMYND10, DNAAF1, DYX1C1, CCDC103
cellular component movement (GO:0006928)	-	2.61	0.0	DYX1C1, RSPH4A, DNAH1, ARMC4, DNAI1, DNAH8, DNAH11, CCDC103, DNAAF2, RSPH9, CCDC39, CCDC40, GAS8, HYDIN, DNAAF1, DNAH5, DRC1, LRRC6
cellular macromolecular complex assembly (GO:0034622)	-	3.18	0.0	DYX1C1, ZMYND10, ARMC4, CCDC114, CCDC39, CENPF, DNAAF2, CCDC103, CCDC40, DNAAF1, SPAG1, DRC1, LRRC6, DNAAF3
specification of symmetry (GO:0009799)	-	5.36	0.001	CCDC40, DNAAF1, DYX1C1, CCDC39, CCDC103
cilium movement (GO:0003341)	-	6.12	0.0	RSPH4A, DNAH1, ARMC4, DNAI1, CCDC39, DYX1C1, RSPH9, CCDC103, CCDC40, HYDIN, DNAAF1, DNAH5, LRRC6
heart looping (GO:0001947)	-	5.65	0.001	CCDC40, DNAAF1, CCDC39, CCDC103
determination of digestive tract left/right asymmetry (GO:0071907)	-	7.78	0.0	CCDC40, DNAAF1, CCDC39, CCDC103
single-organism process (GO:0044699)	-	0.48	0.02	RSPH4A, ZMYND10, CCDC103, LRRC6, DNAI2, DNAI1, CCNO, CCDC39, CENPF, DNAAF2, MCIDAS, GAS8, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DRC1, ARMC4, DNAH8, DNAH11, CCDC40, HYDIN, DNAAF1, SPAG1, DNAAF3
pattern specification process (GO:0007389)	-	3.79	0.001	ARMC4, CCDC39, DYX1C1, CCDC103, CCDC40, DNAAF1, DNAH5
axonemal dynein complex assembly (GO:0070286)	-	6.64	0.0	DYX1C1, DNAAF3, ARMC4, ZMYND10, CCDC39, CCDC114, CCDC103, CCDC40, DNAAF1, SPAG1, DRC1, LRRC6, DNAAF2
protein complex subunit organization (GO:0071822)	-	2.6	0.0	DYX1C1, DNAAF3, ARMC4, ZMYND10, CCDC39, CENPF, CCDC114, CCDC103, CCDC40, DNAAF1, SPAG1, DRC1, LRRC6, DNAAF2
axoneme assembly (GO:0035082)	-	6.68	0.001	RSPH9, RSPH4A, RSPH1
determination of left/right symmetry (GO:0007368)	-	5.38	0.001	DYX1C1, CCDC40, DNAAF1, CCDC39, CCDC103
epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	-	7.65	0.0	CCDC40, DNAAF1, CCDC39, LRRC6, CCDC103
cellular component organization (GO:0016043)	-	1.24	0.0	RSPH4A, ZMYND10, CCDC39, LRRC6, DNAI2, DNAI1, CCDC114, CCDC103, CENPF, DRC1, DNAAF2, MCIDAS, RSPH1, DYX1C1, RSPH9, DNAAF1, ARMC4, CCDC40, HYDIN, CCNO, SPAG1, DNAAF3
cilium-dependent cell motility (GO:0060285)	-	8.34	0.0	DNAAF2, DRC1, CCDC39
macromolecular complex assembly (GO:0065003)	-	2.55	0.0	DYX1C1, ZMYND10, CCDC40, ARMC4, CCDC114, CCDC39, CENPF, DNAAF2, CCDC103, NME8, DNAAF1, SPAG1, DRC1, LRRC6, DNAAF3
macromolecular complex subunit organization (GO:0043933)	-	2.14	0.0	DYX1C1, DNAAF3, ARMC4, ZMYND10, CCDC39, CENPF, CCDC114, CCDC103, CCDC40, DNAAF1, SPAG1, DRC1, LRRC6, DNAAF2
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.0	RSPH4A, ZMYND10, CCDC39, LRRC6, DNAI2, DNAI1, DNAAF2, CCDC103, CENPF, DRC1, CCDC114, MCIDAS, RSPH1, DYX1C1, HYDIN, DNAAF1, ARMC4, CCDC40, RSPH9, CCNO, SPAG1, DNAAF3
cell projection assembly (GO:0030031)	-	4.19	0.0	RSPH4A, RSPH1, HYDIN, ZMYND10, RSPH9, DNAAF3, MCIDAS, DNAI2, CCNO, DNAAF1, LRRC6
epithelial tube morphogenesis (GO:0060562)	-	5.12	0.004	CCDC40, DNAAF1, CCDC39, CCDC103
motile cilium assembly (GO:0044458)	-	7.02	0.0	ZMYND10, DNAAF1, DNAAF3, LRRC6
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.0	RSPH4A, DNAI2, HYDIN, ZMYND10, RSPH9, DNAAF3, MCIDAS, RSPH1, CCNO, DNAAF1, LRRC6
developmental process (GO:0032502)	-	1.36	0.001	DNAAF3, RSPH4A, HYDIN, DNAI2, CCDC40, ARMC4, DYX1C1, CCDC103, MCIDAS, CENPF, ZMYND10, RSPH9, CCDC39, NME8, RSPH1, CCNO, DNAH5, DNAAF1, LRRC6
bacterial-type flagellum-dependent cell motility (GO:0071973)	-	9.04	0.001	DNAAF2, DRC1
cilium assembly (GO:0042384)	-	4.77	0.0	DNAI2, ZMYND10, HYDIN, DNAAF3, MCIDAS, CCNO, DNAAF1, LRRC6
tube morphogenesis (GO:0035239)	-	4.35	0.007	CCDC40, DNAAF1, CCDC39, CCDC103
protein complex assembly (GO:0006461)	-	2.78	0.001	DYX1C1, DNAAF3, CCDC40, ARMC4, ZMYND10, CCDC39, CENPF, CCDC114, CCDC103, NME8, DNAAF1, SPAG1, DRC1, LRRC6, DNAAF2
single-organism developmental process (GO:0044767)	-	1.49	0.0	DNAAF3, RSPH4A, HYDIN, DNAI2, CCDC40, ARMC4, DYX1C1, CCDC39, MCIDAS, CENPF, ZMYND10, RSPH9, CCDC103, NME8, RSPH1, DNAAF1, DNAH5, CCNO, LRRC6
single-organism cellular process (GO:0044763)	-	0.65	0.001	RSPH4A, ZMYND10, CCDC103, LRRC6, DNAI2, DNAI1, CCNO, CCDC39, CENPF, DNAAF2, MCIDAS, GAS8, RSPH1, NME8, DYX1C1, HYDIN, DNAH1, DNAH5, DRC1, ARMC4, DNAH8, DNAH11, CCDC40, RSPH9, DNAAF1, DNAAF3
determination of pancreatic left/right asymmetry (GO:0035469)	-	8.12	0.0	DNAAF1, CCDC40, CCDC39
regulation of cilium beat frequency (GO:0003356)	-	7.33	0.001	DNAAF1, CCDC40
organelle assembly (GO:0070925)	-	3.75	0.002	DNAI2, CENPF, ZMYND10, HYDIN, DNAAF3, MCIDAS, CCNO, DNAAF1, LRRC6
cellular protein complex assembly (GO:0043623)	-	3.9	0.0	DYX1C1, ZMYND10, ARMC4, CCDC114, CCDC39, CENPF, DNAAF2, CCDC103, CCDC40, DNAAF1, SPAG1, DRC1, LRRC6, DNAAF3
regulation of cilium movement (GO:0003352)	-	7.24	0.033	DNAAF1, CCDC40
epithelial cilium movement (GO:0003351)	-	6.78	0.0	DNAI1, CCDC39, CCDC103, CCDC40, DNAAF1, LRRC6
archaeal or bacterial-type flagellum-dependent cell motility (GO:0097588)	-	9.04	0.001	DNAAF2, DRC1
locomotion (GO:0040011)	-	2.91	0.011	GAS8, DNAH1, DYX1C1, CCDC39, DNAH8, DRC1, LRRC6, DNAAF2
embryonic heart tube morphogenesis (GO:0003143)	-	5.57	0.001	CCDC40, DNAAF1, CCDC39, CCDC103
microtubule-based process (GO:0007017)	-	3.54	0.0	RSPH4A, CCDC39, RSPH1, ARMC4, DNAI1, DNAH8, DNAH11, HYDIN, DYX1C1, RSPH9, CCDC103, CCDC40, DNAH1, DNAAF1, DNAH5, LRRC6
determination of liver left/right asymmetry (GO:0071910)	-	7.94	0.0	DNAAF1, CCDC40, CCDC39
cell motility (GO:0048870)	-	3.02	0.004	GAS8, DNAH1, DNAH8, CCDC39, DYX1C1, DRC1, LRRC6, DNAAF2
microtubule bundle formation (GO:0001578)	-	5.9	0.014	RSPH9, RSPH4A, RSPH1
microtubule-based movement (GO:0007018)	-	4.39	0.0	RSPH4A, DNAH1, ARMC4, DNAI1, DYX1C1, DNAH11, CCDC103, DNAH8, RSPH9, CCDC39, CCDC40, HYDIN, DNAAF1, DNAH5, LRRC6
outer dynein arm assembly (GO:0036158)	-	7.24	0.0	DYX1C1, ARMC4, CCDC114, CCDC103, ZMYND10, DNAAF1, LRRC6
cellular component assembly involved in morphogenesis (GO:0010927)	-	4.29	0.0	RSPH4A, RSPH1, HYDIN, ZMYND10, RSPH9, DNAAF3, MCIDAS, DNAI2, CCNO, DNAAF1, LRRC6
determination of bilateral symmetry (GO:0009855)	-	5.37	0.0	CCDC40, DNAAF1, DYX1C1, CCDC39, CCDC103
cilium or flagellum-dependent cell motility (GO:0001539)	-	7.33	0.0	DRC1, DNAAF2, DNAH1, DNAH8, CCDC39
cilium organization (GO:0044782)	-	4.67	0.0	DNAI2, ZMYND10, HYDIN, DNAAF3, MCIDAS, CCNO, DNAAF1, LRRC6

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	31	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, CCDC114, DNAI2, DNAI1, CCNO, CCDC39, CENPF, DNAAF2, MCIDAS, DNAAF5, GAS8, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, DNAH8, DNAH11, CCDC40, HYDIN, DRC1, CCDC151, DNAAF3
cell part (GO:0044464)	0.11	31	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, CCDC114, DNAI2, DNAI1, CCNO, CCDC39, CENPF, DNAAF2, MCIDAS, DNAAF5, GAS8, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, DNAH8, DNAH11, CCDC40, HYDIN, DRC1, CCDC151, DNAAF3
organelle (GO:0043226)	0.4	29	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, DNAI2, DNAI1, CCNO, CCDC39, CENPF, CCDC114, MCIDAS, DNAAF5, GAS8, RSPH1, NME8, DYX1C1, HYDIN, DNAH1, DNAH5, DNAAF1, ARMC4, CCDC151, DNAH8, DNAH11, CCDC40, RSPH9, DRC1, SPAG1
cytoplasm (GO:0005737)	1.01	28	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, DNAI2, DNAI1, CCNO, CCDC39, CENPF, DNAAF2, NME8, DNAAF5, GAS8, RSPH1, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, SPAG1, DNAH8, DNAH11, CCDC40, DRC1, CCDC151, DNAAF3
intracellular organelle part (GO:0044446)	0.81	25	RSPH4A, ZMYND10, CCDC103, DNAI2, DNAI1, CCNO, CCDC39, CENPF, CCDC114, MCIDAS, GAS8, RSPH1, NME8, HYDIN, DNAH1, DNAH5, DRC1, ARMC4, CCDC151, DNAH8, DNAH11, CCDC40, RSPH9, DNAAF1, SPAG1
organelle part (GO:0044422)	0.79	25	RSPH4A, DNAH8, CCDC103, DNAI2, DNAI1, CCNO, CCDC39, CENPF, CCDC114, MCIDAS, GAS8, RSPH1, NME8, HYDIN, DNAH1, DNAH5, DRC1, ARMC4, CCDC151, ZMYND10, DNAH11, CCDC40, RSPH9, DNAAF1, SPAG1
intracellular organelle (GO:0043229)	0.51	22	RSPH4A, DNAH8, C21orf59, DNAH1, DNAI1, CCDC39, CENPF, DRC1, MCIDAS, GAS8, RSPH1, DYX1C1, RSPH9, DNAI2, DNAH5, DNAAF1, ARMC4, CCDC151, ZMYND10, DNAH11, CCNO, SPAG1
cytoskeletal part (GO:0044430)	2.49	22	RSPH4A, DNAH8, CCDC103, DNAI2, DNAI1, CCDC39, CENPF, CCDC114, NME8, GAS8, RSPH1, RSPH9, DNAH1, DNAH5, DRC1, ARMC4, ZMYND10, DNAH11, CCDC40, HYDIN, DNAAF1, CCDC151
cell projection (GO:0042995)	2.47	21	RSPH4A, RSPH1, ARMC4, CCDC151, DNAI1, DNAI2, CCDC114, DNAH11, CCDC103, HYDIN, DNAH8, RSPH9, CCDC39, CCDC40, GAS8, DNAH1, DNAAF5, DNAH5, DRC1, LRRC6, DNAAF1
cilium (GO:0005929)	3.89	21	RSPH4A, RSPH1, ARMC4, CCDC151, DNAI1, DNAI2, GAS8, DNAH11, CCDC103, HYDIN, DNAAF5, DNAH8, RSPH9, CCDC39, CCDC40, DNAH1, DRC1, DNAH5, DNAAF1, LRRC6, CCDC114
cell projection part (GO:0044463)	2.97	19	RSPH4A, HYDIN, RSPH1, CCDC40, ARMC4, CCDC151, DNAI1, CCDC114, CCDC103, CENPF, DNAH8, DNAH1, RSPH9, CCDC39, NME8, DNAI2, DNAAF1, DNAH5, DRC1
non-membrane-bounded organelle (GO:0043228)	1.76	19	ZMYND10, RSPH4A, RSPH1, ARMC4, SPAG1, DNAI1, DNAI2, GAS8, DNAH11, CENPF, DNAH8, RSPH9, CCDC39, MCIDAS, DNAH1, DNAAF1, DNAH5, DRC1, CCDC151
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	19	ZMYND10, RSPH4A, RSPH1, ARMC4, SPAG1, DNAI1, DNAI2, GAS8, DNAH11, CENPF, DNAH8, RSPH9, CCDC39, MCIDAS, DNAH1, DNAAF1, DNAH5, DRC1, CCDC151
ciliary part (GO:0044441)	4.05	19	RSPH4A, HYDIN, DNAI2, CCDC40, ARMC4, CCDC151, DNAI1, DNAH8, CCDC39, CENPF, CCDC114, DNAH1, RSPH9, CCDC103, NME8, RSPH1, DNAAF1, DNAH5, DRC1
cytoskeleton (GO:0005856)	2.55	17	ZMYND10, RSPH4A, DNAH1, ARMC4, SPAG1, DNAI1, GAS8, DNAH11, CENPF, DNAH8, RSPH9, CCDC39, DNAI2, DRC1, DNAH5, DNAAF1, CCDC151
axoneme (GO:0005930)	5.53	13	RSPH4A, DNAI2, ARMC4, CCDC151, CCDC39, CENPF, CCDC114, RSPH9, CCDC103, CCDC40, DNAAF1, DNAH5, DRC1
membrane-bounded organelle (GO:0043227)	0.47	11	RSPH4A, RSPH1, NME8, ARMC4, GAS8, MCIDAS, CENPF, DYX1C1, C21orf59, DNAAF1, CCNO
protein complex (GO:0043234)	1.51	10	RSPH4A, DNAH1, DNAI1, DNAH8, DNAH11, CENPF, CCDC114, NME8, DNAI2, DNAH5
macromolecular complex (GO:0032991)	1.35	10	RSPH4A, DNAH1, DNAI1, CCDC114, DNAH11, CENPF, DNAH8, NME8, DNAI2, DNAH5
intracellular membrane-bounded organelle (GO:0043231)	0.6	10	GAS8, RSPH1, C21orf59, ARMC4, RSPH4A, CENPF, DYX1C1, MCIDAS, DNAAF1, CCNO
axoneme part (GO:0044447)	6.67	9	RSPH4A, DNAI2, DNAI1, DNAH8, CCDC114, HYDIN, NME8, DNAH1, DNAH5
nucleus (GO:0005634)	1.07	9	RSPH4A, RSPH1, C21orf59, ARMC4, CENPF, DYX1C1, MCIDAS, DNAAF1, CCNO
supramolecular fiber (GO:0099512)	3.31	8	GAS8, DNAH1, DNAI1, DNAI2, DNAH11, DNAH8, RSPH1, DNAH5
polymeric cytoskeletal fiber (GO:0099513)	3.31	8	GAS8, DNAI2, DNAI1, DNAH11, DNAH8, DNAH1, RSPH1, DNAH5
motile cilium (GO:0031514)	5.36	8	GAS8, DNAI2, RSPH4A, CCDC103, DNAH1, RSPH9, RSPH1, DNAAF5
dynein complex (GO:0030286)	6.04	8	DNAH1, DNAI1, CCDC114, DNAH11, DNAH8, NME8, DNAI2, DNAH5
microtubule associated complex (GO:0005875)	4.79	8	DNAI2, DNAI1, DNAH8, DNAH11, CCDC114, NME8, DNAH1, DNAH5
catalytic complex (GO:1902494)	2.9	8	DNAI2, DNAI1, CCDC114, DNAH11, DNAH8, NME8, DNAH1, DNAH5
nuclear part (GO:0044428)	1.55	7	RSPH4A, RSPH1, ARMC4, CENPF, MCIDAS, CCNO, SPAG1
microtubule (GO:0005874)	3.81	7	GAS8, DNAH1, DNAI1, DNAH11, DNAH8, DNAI2, DNAH5
axonemal dynein complex (GO:0005858)	7.16	7	DNAI2, DNAI1, DNAH8, CCDC114, NME8, DNAH1, DNAH5
cytoplasmic part (GO:0044444)	0.82	6	GAS8, RSPH1, CENPF, ZMYND10, C21orf59, CCDC151
nucleoplasm (GO:0005654)	1.89	5	CENPF, CCNO, SPAG1, RSPH4A, ARMC4
outer dynein arm (GO:0036157)	8.19	5	DNAH5, DNAI1, DNAI2, CCDC114, NME8
sperm part (GO:0097223)	4.83	5	DNAI2, DNAH8, DNAH1, RSPH1, NME8
sperm flagellum (GO:0036126)	6.76	3	DNAI2, DNAH1, RSPH1
cytosol (GO:0005829)	1.68	3	CENPF, RSPH1, C21orf59
microtubule organizing center (GO:0005815)	3.42	3	CENPF, ZMYND10, CCDC151
ciliary basal body (GO:0036064)	5.36	2	CENPF, CCDC151
spindle (GO:0005819)	4.52	2	CENPF, RSPH1
sperm principal piece (GO:0097228)	6.91	2	DNAH8, NME8
nucleolus (GO:0005730)	3.06	2	RSPH4A, MCIDAS
membrane (GO:0016020)	0.68	2	DNAAF1, DYX1C1
spindle pole (GO:0000922)	5.08	2	CENPF, DNAAF1
microtubule organizing center part (GO:0044450)	4.8	2	ZMYND10, CCDC151
plasma membrane (GO:0005886)	1.39	2	DNAAF1, DYX1C1
chromosome (GO:0005694)	3.78	2	CENPF, RSPH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytoskeleton (GO:0005856)	-	2.55	0.008	RSPH4A, ARMC4, DNAI1, CCDC39, RSPH9, DRC1, SPAG1
catalytic complex (GO:1902494)	-	2.9	0.01	DNAH1, DNAI1, DNAH8, DNAH11, CCDC114, DNAI2, DNAH5
motile cilium (GO:0031514)	-	5.36	0.001	RSPH1, GAS8, RSPH9, RSPH4A, CCDC103
cell projection part (GO:0044463)	-	2.97	0.0	RSPH4A, DNAI2, ARMC4, GAS8, CCDC39, CENPF, DNAH8, RSPH9, CCDC103, DNAH1, DNAAF1, DNAH5, DRC1, CCDC114
cilium (GO:0005929)	-	3.89	0.0	RSPH4A, RSPH1, DNAI1, GAS8, DNAH11, HYDIN, CCDC114, RSPH9, CCDC103, CCDC40, DNAI2, LRRC6
axonemal dynein complex (GO:0005858)	-	7.16	0.0	DNAH5, DNAI2, DNAH8, DNAH1, CCDC114
microtubule associated complex (GO:0005875)	-	4.79	0.0	DNAH1, DNAI1, CCDC114, DNAH11, DNAH8, DNAI2, DNAH5
axoneme part (GO:0044447)	-	6.67	0.0	RSPH4A, DNAH1, CCDC114, DNAH8, DNAI2, DNAH5
cytoplasmic dynein complex (GO:0005868)	NEW	7.09	0.0	DNAI2, DNAH8, DNAH1, DNAH5, CCDC114
cytoskeletal part (GO:0044430)	-	2.49	0.0	GAS8, DNAI2, DNAH8, DNAI1, ZMYND10, DNAH11, CENPF, CCDC114, DNAH1, DNAAF1, DNAH5
ciliary part (GO:0044441)	-	4.05	0.0	RSPH4A, DNAI2, ARMC4, GAS8, CCDC39, DNAH8, CCDC114, RSPH9, CCDC103, DNAH1, DNAAF1, DNAH5, DRC1
intracellular part (GO:0044424)	-	0.28	0.037	RSPH4A, ZMYND10, CCDC103, C21orf59, LRRC6, CCDC114, DNAI2, DNAI1, CCNO, CCDC39, CENPF, DNAAF2, MCIDAS, DNAAF5, GAS8, RSPH1, NME8, DYX1C1, RSPH9, DNAH1, DNAH5, DNAAF1, ARMC4, DNAH8, DNAH11, CCDC40, DRC1, SPAG1, DNAAF3
dynein complex (GO:0030286)	-	6.04	0.0	DNAI2, DNAI1, CCDC114, DNAH11, DNAH8, DNAH1, DNAH5
cell projection (GO:0042995)	-	2.47	0.045	RSPH4A, HYDIN, RSPH1, DNAI1, GAS8, DNAH11, CENPF, CCDC114, RSPH9, CCDC103, CCDC40, DNAI2, LRRC6
microtubule (GO:0005874)	-	3.81	0.002	GAS8, DNAH1, DNAI1, DNAH11, CENPF, DNAH8, DNAI2, DNAH5
axoneme (GO:0005930)	-	5.53	0.0	RSPH4A, DNAI2, ARMC4, CCDC39, RSPH9, CCDC103, DRC1, DNAH5, DNAAF1