Disease table of FOCAL SEGMENTAL GLOMERULOSCLEROSIS OMIM ID: PS603278

Gene-disease associations table

GeneAssociated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ACTN4ClinVar, OMIM, HUMSAVARHGNC link19q13.21PS603278
MYO1EClinVar, OMIM, HUMSAVARHGNC link15q22.21PS603278
ANLNClinVar, OMIM, HUMSAVARHGNC link7p14.21PS603278
CRB2ClinVar, OMIM, HUMSAVARHGNC link9q33.32219730, PS603278
TRPC6ClinVar, OMIM, HUMSAVARHGNC link11q22.11PS603278
PAX2ClinVar, OMIM, HUMSAVARHGNC link10q24.312120330, PS603278
CD2APOMIMHGNC link6p12.31PS603278
INF2ClinVar, OMIM, HUMSAVARHGNC link14q32.332PS603278, 614455
APOL1ClinVar, OMIM, HUMSAVARHGNC link22q12.31PS603278

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
PAX2YES7WT1, L1CAM, TP53, ERBB2, ADAM10, NCAM1, SFRP20
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PAX2YES1WT10
CD2APYES4SP1, SP3, E2F1, LMX1B0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ACTN4MYO1ENo19MYO1C, MYO19, CALML3, ACTB, PDLIM7, IQGAP1, MYH9, PPP1CB, CAPZA2, MAPRE1, TMOD3, MYO18A, MYO5C, MYH10, FLNA, LIMA1, ANLN, SYNPO, DBN1
ACTN4ANLNYes17MYO1C, MYO19, ACTN1, MYO5C, MYH9, TPM3, SVIL, CAPZA2, PPP1CB, TPM2, TPM1, MYO18A, TPM4, LIMA1, FLNA, SYNPO, DBN1
ACTN4CD2APNo6HUWE1, VCAM1, CAPZA2, TSG101, EGFR, ITGA4
ACTN4INF2No22TPM1, VCP, ANLN, MYO19, MYH9, LIMA1, CORO1C, IQGAP1, MYO18A, DBN1, FLNB, PPP1CB, ACTB, TMOD3, MYO1C, FLOT2, CALML3, MYO5C, CAPZA2, MYH10, FLNA, SYNPO
MYO1EANLNYes12MYO19, MYO5C, ARPC4, MYH9, PPP1CB, CAPZA2, MYO5A, DBN1, MYO18A, LIMA1, FLNA, SYNPO
MYO1ECRB2No1CTTN
MYO1ECD2APNo3CAPZA2, ASNS, CTTN
MYO1EINF2No20IQGAP1, MYH11, TMOD3, CALML3, CAPZA2, ANLN, MYO18A, PPP1CB, MYO1C, MYO19, ACTB, MOV10, MYH9, DBN1, MYO5C, MYH10, FLNA, LIMA1, NXF1, SYNPO
ANLNTRPC6No2FYN, ITPR3
ANLNCD2APNo6SH3KBP1, NR3C1, CAPZA1, CAPZB, CAPZA2, LMNA
ANLNINF2Yes13MYO1C, MYO19, CRK, MYO5C, MYH9, PPP1CB, ACTR2, CAPZA2, DBN1, MYO18A, LIMA1, FLNA, SYNPO
CRB2CD2APNo1CTTN
CD2APINF2No1CAPZA2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ACTN4MYO1ENo-2UBC, SLC2A4
ACTN4TRPC6Yesbinding1SRC
ACTN4CD2APNo-6PIK3CA, PIK3R1, UBC, GRB2, VEGFA, BCAR1
ACTN4INF2No-1UBC
MYO1ETRPC6No-2NPHS1, KIRREL
MYO1ECD2APNo-4UBC, DNM2, NPHS1, KIRREL
MYO1EINF2No-1UBC
ANLNCD2APYesbinding1SH3KBP1
TRPC6PAX2No-2MAPK8, JUN
TRPC6CD2APNo-4FYN, NPHS1, NPHS2, KIRREL
CD2APINF2No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
ACTN4MYO1ENo-1ACTB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cell-Cell communicationR-HSA-15009315.872ACTN4, CD2AP
Platelet activation, signaling and aggregationR-HSA-760025.152ACTN4, TRPC6
HemostasisR-HSA-1095823.982ACTN4, TRPC6
Nephrin interactionsR-HSA-3737538.462ACTN4, CD2AP

NET-GE enrichment

Term New enriched termICP valueGenes
Cell-Cell communication (R-HSA-1500931) -5.870.046ACTN4, CD2AP
Nephrin interactions (R-HSA-373753) -8.460.001CD2AP, ACTN4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, APOL1, MYO1E, ACTN4
protein binding (GO:0005515) 0.469CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, APOL1, MYO1E, ACTN4
actin binding (GO:0003779) 3.745ANLN, ACTN4, TRPC6, MYO1E, INF2
cytoskeletal protein binding (GO:0008092) 3.025ANLN, ACTN4, TRPC6, MYO1E, INF2
organic cyclic compound binding (GO:0097159) 1.053PAX2, ACTN4, MYO1E
enzyme binding (GO:0019899) 2.273INF2, CRB2, TRPC6
small molecule binding (GO:0036094) 1.893ACTN4, TRPC6, MYO1E
macromolecular complex binding (GO:0044877) 2.613CD2AP, ACTN4, MYO1E
protein complex binding (GO:0032403) 3.093CD2AP, ACTN4, MYO1E
heterocyclic compound binding (GO:1901363) 1.063PAX2, ACTN4, MYO1E
nucleic acid binding (GO:0003676) 1.442PAX2, ACTN4
DNA binding (GO:0003677) 1.922PAX2, ACTN4
nucleoside binding (GO:0001882) 2.212ACTN4, MYO1E
sequence-specific DNA binding (GO:0043565) 2.792PAX2, ACTN4
sequence-specific double-stranded DNA binding (GO:1990837) 3.22PAX2, ACTN4
ion binding (GO:0043167) 1.362CRB2, ACTN4
calcium ion binding (GO:0005509) 3.172CRB2, ACTN4
passive transmembrane transporter activity (GO:0022803) 3.62APOL1, TRPC6
double-stranded DNA binding (GO:0003690) 3.092PAX2, ACTN4
metal ion binding (GO:0046872) 1.412CRB2, ACTN4
transcription factor binding (GO:0008134) 3.462PAX2, ACTN4
cation binding (GO:0043169) 1.42CRB2, ACTN4
transporter activity (GO:0005215) 2.572APOL1, TRPC6
ion channel activity (GO:0005216) 3.712APOL1, TRPC6
regulatory region nucleic acid binding (GO:0001067) 3.032PAX2, ACTN4
lipid binding (GO:0008289) 3.262APOL1, MYO1E
actin filament binding (GO:0051015) 4.932ACTN4, MYO1E
catalytic activity (GO:0003824) 1.052PAX2, MYO1E
cell adhesion molecule binding (GO:0050839) 4.52ACTN4, CD2AP
substrate-specific transmembrane transporter activity (GO:0022891) 2.92APOL1, TRPC6
transcription regulatory region DNA binding (GO:0044212) 3.032PAX2, ACTN4
substrate-specific transporter activity (GO:0022892) 2.722APOL1, TRPC6
carbohydrate derivative binding (GO:0097367) 2.032ACTN4, MYO1E
ion transmembrane transporter activity (GO:0015075) 3.042APOL1, TRPC6
transmembrane transporter activity (GO:0022857) 2.822APOL1, TRPC6
channel activity (GO:0015267) 3.62APOL1, TRPC6
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242PAX2, ACTN4
regulatory region DNA binding (GO:0000975) 3.032PAX2, ACTN4
receptor binding (GO:0005102) 2.432ACTN4, CD2AP
substrate-specific channel activity (GO:0022838) 3.672APOL1, TRPC6

NET-GE enrichment

Term New enriched termICP valueGenes
actin binding (GO:0003779) -3.740.009CD2AP, INF2, ACTN4, ANLN, MYO1E
cytoskeletal protein binding (GO:0008092) -3.020.037INF2, ANLN, CD2AP, TRPC6, MYO1E, ACTN4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.269CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, APOL1, MYO1E, ACTN4
biological regulation (GO:0065007) 0.399CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, APOL1, MYO1E, ACTN4
single-organism process (GO:0044699) 0.489CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, APOL1, MYO1E, ACTN4
single-organism cellular process (GO:0044763) 0.658CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, MYO1E, ACTN4
regulation of biological process (GO:0050789) 0.458CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, MYO1E, ACTN4
regulation of cellular process (GO:0050794) 0.58CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, MYO1E, ACTN4
regulation of cellular component organization (GO:0051128) 2.017CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, ACTN4
cellular component organization (GO:0016043) 1.246INF2, ANLN, CD2AP, PAX2, MYO1E, ACTN4
cellular component organization or biogenesis (GO:0071840) 1.226INF2, ANLN, CD2AP, PAX2, MYO1E, ACTN4
regulation of developmental process (GO:0050793) 2.15CRB2, ACTN4, INF2, TRPC6, PAX2
positive regulation of biological process (GO:0048518) 1.25ACTN4, PAX2, CD2AP, CRB2, TRPC6
regulation of anatomical structure morphogenesis (GO:0022603) 2.795CRB2, ACTN4, INF2, TRPC6, PAX2
negative regulation of biological process (GO:0048519) 1.335ACTN4, CRB2, CD2AP, PAX2, TRPC6
regulation of cell morphogenesis (GO:0022604) 3.44CRB2, ACTN4, PAX2, TRPC6
regulation of primary metabolic process (GO:0080090) 1.084PAX2, ACTN4, CRB2, TRPC6
regulation of metabolic process (GO:0019222) 1.024PAX2, ACTN4, CRB2, TRPC6
cell differentiation (GO:0030154) 2.144ANLN, TRPC6, MYO1E, PAX2
regulation of cellular metabolic process (GO:0031323) 1.074PAX2, ACTN4, CRB2, TRPC6
movement of cell or subcellular component (GO:0006928) 2.614CD2AP, ANLN, ACTN4, MYO1E
metabolic process (GO:0008152) 0.584PAX2, CD2AP, APOL1, MYO1E
signal transduction (GO:0007165) 1.284ACTN4, PAX2, CD2AP, MYO1E
cellular developmental process (GO:0048869) 1.824ANLN, TRPC6, MYO1E, PAX2
regulation of cell development (GO:0060284) 3.014CRB2, ACTN4, PAX2, TRPC6
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.914CRB2, ACTN4, PAX2, TRPC6
regulation of molecular function (GO:0065009) 1.784CRB2, ACTN4, PAX2, TRPC6
developmental process (GO:0032502) 1.364CRB2, TRPC6, MYO1E, PAX2
regulation of macromolecule metabolic process (GO:0060255) 1.084CRB2, ACTN4, PAX2, TRPC6
transport (GO:0006810) 1.514ACTN4, APOL1, TRPC6, MYO1E
single-organism developmental process (GO:0044767) 1.494PAX2, CRB2, TRPC6, MYO1E
response to stress (GO:0006950) 1.84PAX2, ACTN4, APOL1, TRPC6
regulation of multicellular organismal process (GO:0051239) 1.874PAX2, CD2AP, CRB2, TRPC6
establishment of localization (GO:0051234) 1.484ACTN4, APOL1, TRPC6, MYO1E
localization (GO:0051179) 1.44ACTN4, APOL1, TRPC6, MYO1E
response to stimulus (GO:0050896) 1.224PAX2, ACTN4, APOL1, TRPC6
regulation of cell differentiation (GO:0045595) 2.424CRB2, ACTN4, PAX2, TRPC6
negative regulation of cellular process (GO:0048523) 1.414PAX2, ACTN4, CRB2, TRPC6
positive regulation of cellular process (GO:0048522) 1.34CRB2, ACTN4, PAX2, TRPC6
cellular component assembly (GO:0022607) 2.143ACTN4, ANLN, CD2AP
regulation of organelle organization (GO:0033043) 2.723ANLN, CD2AP, INF2
regulation of transport (GO:0051049) 2.243ACTN4, CD2AP, TRPC6
positive regulation of multicellular organismal process (GO:0051240) 2.493PAX2, CRB2, TRPC6
negative regulation of multicellular organismal process (GO:0051241) 2.843PAX2, CD2AP, TRPC6
regulation of protein metabolic process (GO:0051246) 1.933PAX2, CRB2, TRPC6
organic substance metabolic process (GO:0071704) 0.633PAX2, CD2AP, APOL1
positive regulation of cell development (GO:0010720) 3.573CRB2, PAX2, TRPC6
regulation of cellular biosynthetic process (GO:0031326) 1.383CRB2, ACTN4, PAX2
regulation of biological quality (GO:0065008) 1.683PAX2, APOL1, TRPC6
positive regulation of cellular component organization (GO:0051130) 2.683CRB2, ACTN4, PAX2
negative regulation of developmental process (GO:0051093) 3.173PAX2, ACTN4, TRPC6
multicellular organismal process (GO:0032501) 1.453PAX2, CRB2, MYO1E
actin filament-based process (GO:0030029) 3.943INF2, ACTN4, MYO1E
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433CRB2, ACTN4, PAX2
regulation of biosynthetic process (GO:0009889) 1.373PAX2, ACTN4, CRB2
regulation of nucleic acid-templated transcription (GO:1903506) 1.553CRB2, ACTN4, PAX2
positive regulation of cell differentiation (GO:0045597) 3.013PAX2, CRB2, TRPC6
regulation of nitrogen compound metabolic process (GO:0051171) 1.363CRB2, ACTN4, PAX2
regulation of RNA biosynthetic process (GO:2001141) 1.553CRB2, ACTN4, PAX2
regulation of localization (GO:0032879) 1.943CD2AP, ACTN4, TRPC6
organelle organization (GO:0006996) 2.023ANLN, CD2AP, INF2
primary metabolic process (GO:0044238) 0.693PAX2, CD2AP, APOL1
regulation of cellular protein metabolic process (GO:0032268) 1.993CRB2, PAX2, TRPC6
vesicle-mediated transport (GO:0016192) 2.723ACTN4, APOL1, MYO1E
single-multicellular organism process (GO:0044707) 1.783CRB2, PAX2, MYO1E
positive regulation of developmental process (GO:0051094) 2.773CRB2, PAX2, TRPC6
anatomical structure development (GO:0048856) 1.583CRB2, PAX2, MYO1E
macromolecule metabolic process (GO:0043170) 0.833PAX2, CD2AP, APOL1
regulation of macromolecule biosynthetic process (GO:0010556) 1.433CRB2, ACTN4, PAX2
regulation of multicellular organismal development (GO:2000026) 2.313PAX2, CRB2, TRPC6
regulation of RNA metabolic process (GO:0051252) 1.523CRB2, ACTN4, PAX2
positive regulation of response to stimulus (GO:0048584) 2.182CRB2, ACTN4
regulation of response to stimulus (GO:0048583) 1.542CRB2, ACTN4
positive regulation of transmembrane transport (GO:0034764) 4.992ACTN4, TRPC6
regulation of ion transmembrane transport (GO:0034765) 3.772ACTN4, TRPC6
positive regulation of ion transmembrane transport (GO:0034767) 5.052ACTN4, TRPC6
organic cyclic compound metabolic process (GO:1901360) 1.262PAX2, APOL1
cellular response to stimulus (GO:0051716) 1.972PAX2, TRPC6
negative regulation of macromolecule metabolic process (GO:0010605) 2.012CRB2, PAX2
positive regulation of macromolecule metabolic process (GO:0010604) 1.812PAX2, TRPC6
regulation of signal transduction (GO:0009966) 1.842CRB2, ACTN4
positive regulation of signal transduction (GO:0009967) 2.52CRB2, ACTN4
kidney development (GO:0001822) 4.792PAX2, MYO1E
transmembrane transport (GO:0055085) 2.722APOL1, TRPC6
animal organ development (GO:0048513) 2.532PAX2, MYO1E
positive regulation of molecular function (GO:0044093) 2.232ACTN4, TRPC6
negative regulation of molecular function (GO:0044092) 2.742PAX2, CRB2
cellular homeostasis (GO:0019725) 3.232PAX2, TRPC6
positive regulation of transport (GO:0051050) 2.92ACTN4, TRPC6
actin filament-based movement (GO:0030048) 5.542ACTN4, MYO1E
regulation of proteolysis (GO:0030162) 3.22CRB2, PAX2
regionalization (GO:0003002) 4.242CRB2, PAX2
response to inorganic substance (GO:0010035) 3.562PAX2, TRPC6
system process (GO:0003008) 2.32PAX2, MYO1E
cell motility (GO:0048870) 3.022ANLN, CD2AP
chemical homeostasis (GO:0048878) 2.972PAX2, TRPC6
cellular response to stress (GO:0033554) 2.512PAX2, TRPC6
negative regulation of peptidase activity (GO:0010466) 4.222CRB2, PAX2
positive regulation of ion transmembrane transporter activity (GO:0032414) 5.552ACTN4, TRPC6
negative regulation of metabolic process (GO:0009892) 1.932PAX2, CRB2
positive regulation of metabolic process (GO:0009893) 1.742PAX2, TRPC6
regulation of ion transmembrane transporter activity (GO:0032412) 4.552ACTN4, TRPC6
response to reactive oxygen species (GO:0000302) 4.52PAX2, TRPC6
nitrogen compound metabolic process (GO:0006807) 1.132PAX2, MYO1E
mitotic nuclear division (GO:0007067) 4.052ANLN, CD2AP
regulation of apoptotic process (GO:0042981) 2.52PAX2, ACTN4
response to hypoxia (GO:0001666) 4.132ACTN4, TRPC6
negative regulation of hydrolase activity (GO:0051346) 3.742PAX2, CRB2
cellular macromolecule metabolic process (GO:0044260) 0.932PAX2, CD2AP
macromolecular complex assembly (GO:0065003) 2.552ANLN, CD2AP
regulation of transmembrane transport (GO:0034762) 3.742ACTN4, TRPC6
inorganic ion transmembrane transport (GO:0098660) 3.382APOL1, TRPC6
cell migration (GO:0016477) 3.122ANLN, CD2AP
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012CRB2, PAX2
ion transport (GO:0006811) 2.662APOL1, TRPC6
regulation of catalytic activity (GO:0050790) 1.972CRB2, PAX2
single-organism metabolic process (GO:0044710) 1.632PAX2, APOL1
system development (GO:0048731) 2.922CRB2, PAX2
regulation of hydrolase activity (GO:0051336) 2.532PAX2, CRB2
endocytosis (GO:0006897) 3.692APOL1, MYO1E
response to hydrogen peroxide (GO:0042542) 5.022PAX2, TRPC6
regulation of transmembrane transporter activity (GO:0022898) 4.522ACTN4, TRPC6
regulation of transcription, DNA-templated (GO:0006355) 1.562PAX2, CRB2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242CRB2, PAX2
negative regulation of cellular component organization (GO:0051129) 3.352ACTN4, TRPC6
positive regulation of signaling (GO:0023056) 2.412CRB2, ACTN4
cellular response to chemical stimulus (GO:0070887) 2.572PAX2, TRPC6
regulation of signaling (GO:0023051) 1.722CRB2, ACTN4
positive regulation of cell communication (GO:0010647) 2.412CRB2, ACTN4
regulation of cell communication (GO:0010646) 1.732CRB2, ACTN4
negative regulation of catalytic activity (GO:0043086) 3.02CRB2, PAX2
cell cycle (GO:0007049) 3.142ANLN, CD2AP
positive regulation of transporter activity (GO:0032411) 5.442ACTN4, TRPC6
negative regulation of protein metabolic process (GO:0051248) 2.822PAX2, CRB2
anatomical structure morphogenesis (GO:0009653) 2.532PAX2, CRB2
nuclear division (GO:0000280) 3.852ANLN, CD2AP
macromolecular complex subunit organization (GO:0043933) 2.142ANLN, CD2AP
regulation of transporter activity (GO:0032409) 4.452ACTN4, TRPC6
locomotion (GO:0040011) 2.912ANLN, CD2AP
cellular response to oxygen-containing compound (GO:1901701) 3.222PAX2, TRPC6
negative regulation of cell development (GO:0010721) 4.022ACTN4, TRPC6
regulation of vesicle-mediated transport (GO:0060627) 3.632CD2AP, ACTN4
positive regulation of ion transport (GO:0043270) 4.362ACTN4, TRPC6
negative regulation of cell differentiation (GO:0045596) 3.332ACTN4, TRPC6
cellular chemical homeostasis (GO:0055082) 3.42PAX2, TRPC6
response to oxidative stress (GO:0006979) 3.92PAX2, TRPC6
negative regulation of cellular protein metabolic process (GO:0032269) 2.882CRB2, PAX2
aging (GO:0007568) 4.162PAX2, TRPC6
response to decreased oxygen levels (GO:0036293) 4.092ACTN4, TRPC6
negative regulation of cell morphogenesis involved in differentiation (GO:0010771) 4.962ACTN4, TRPC6
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.652CRB2, PAX2
negative regulation of proteolysis (GO:0045861) 3.982CRB2, PAX2
cell projection organization (GO:0030030) 3.142PAX2, CD2AP
positive regulation of cellular metabolic process (GO:0031325) 1.812PAX2, TRPC6
negative regulation of cellular metabolic process (GO:0031324) 2.012CRB2, PAX2
mitotic cell cycle process (GO:1903047) 3.122ANLN, CD2AP
homeostatic process (GO:0042592) 2.612PAX2, TRPC6
cell cycle process (GO:0022402) 2.752ANLN, CD2AP
regulation of cell death (GO:0010941) 2.432PAX2, ACTN4
multicellular organism development (GO:0007275) 2.542PAX2, MYO1E
cell division (GO:0051301) 3.682ANLN, CD2AP
pattern specification process (GO:0007389) 3.792CRB2, PAX2
protein complex subunit organization (GO:0071822) 2.62ANLN, CD2AP
positive regulation of nervous system development (GO:0051962) 3.642PAX2, TRPC6
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462PAX2, CRB2
regulation of programmed cell death (GO:0043067) 2.492PAX2, ACTN4
regulation of nervous system development (GO:0051960) 3.12PAX2, TRPC6
regulation of ion transport (GO:0043269) 3.42ACTN4, TRPC6
organic substance transport (GO:0071702) 2.152ACTN4, APOL1
regulation of gene expression (GO:0010468) 1.372PAX2, CRB2
cellular response to hydrogen peroxide (GO:0070301) 5.652PAX2, TRPC6
regulation of peptidase activity (GO:0052547) 3.752CRB2, PAX2
regulation of endopeptidase activity (GO:0052548) 3.82PAX2, CRB2
protein complex assembly (GO:0006461) 2.782ANLN, CD2AP
cellular response to reactive oxygen species (GO:0034614) 5.222PAX2, TRPC6
regulation of metal ion transport (GO:0010959) 3.942ACTN4, TRPC6
ion transmembrane transport (GO:0034220) 3.082APOL1, TRPC6
single-organism transport (GO:0044765) 2.182ACTN4, APOL1
negative regulation of endopeptidase activity (GO:0010951) 4.262CRB2, PAX2
response to chemical (GO:0042221) 1.982PAX2, TRPC6
cellular response to oxidative stress (GO:0034599) 4.72PAX2, TRPC6
regulation of endocytosis (GO:0030100) 4.422CD2AP, ACTN4
single-organism localization (GO:1902578) 2.092ACTN4, APOL1
response to oxygen levels (GO:0070482) 4.022ACTN4, TRPC6
response to oxygen-containing compound (GO:1901700) 2.572PAX2, TRPC6
response to abiotic stimulus (GO:0009628) 2.82ACTN4, TRPC6
cytoskeleton organization (GO:0007010) 3.222ANLN, INF2
cellular metabolic process (GO:0044237) 0.692PAX2, CD2AP
organelle fission (GO:0048285) 3.792ANLN, CD2AP

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of endothelial cell migration (GO:0010595) NEW5.520.03CD2AP, ACTN4, TRPC6
actin filament-based process (GO:0030029) -3.940.031CD2AP, ANLN, ACTN4, INF2, MYO1E
regulation of cellular component organization (GO:0051128) -2.010.024CRB2, ANLN, CD2AP, INF2, PAX2, ACTN4
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.118CRB2, ANLN, CD2AP, INF2, TRPC6, PAX2, MYO1E, ACTN4
intracellular part (GO:0044424) 0.287INF2, ANLN, CD2AP, TRPC6, PAX2, MYO1E, ACTN4
cytoplasmic part (GO:0044444) 0.827INF2, ANLN, CD2AP, TRPC6, PAX2, MYO1E, ACTN4
cytoplasm (GO:0005737) 1.016INF2, ANLN, CD2AP, TRPC6, MYO1E, ACTN4
macromolecular complex (GO:0032991) 1.356CRB2, CD2AP, APOL1, PAX2, MYO1E, ACTN4
membrane-bounded organelle (GO:0043227) 0.476CRB2, ANLN, CD2AP, PAX2, MYO1E, ACTN4
organelle (GO:0043226) 0.46CRB2, ANLN, CD2AP, PAX2, MYO1E, ACTN4
protein complex (GO:0043234) 1.515CD2AP, PAX2, ACTN4, CRB2, MYO1E
intracellular membrane-bounded organelle (GO:0043231) 0.65CD2AP, ANLN, ACTN4, PAX2, MYO1E
intracellular non-membrane-bounded organelle (GO:0043232) 1.765ACTN4, PAX2, CD2AP, ANLN, MYO1E
intracellular organelle part (GO:0044446) 0.815CD2AP, ANLN, ACTN4, PAX2, MYO1E
intracellular organelle (GO:0043229) 0.515CD2AP, ANLN, ACTN4, PAX2, MYO1E
non-membrane-bounded organelle (GO:0043228) 1.765CD2AP, ANLN, ACTN4, PAX2, MYO1E
cytoskeletal part (GO:0044430) 2.495ACTN4, ANLN, CD2AP, PAX2, MYO1E
extracellular region part (GO:0044421) 1.575ACTN4, CRB2, CD2AP, APOL1, MYO1E
organelle part (GO:0044422) 0.795ACTN4, ANLN, CD2AP, PAX2, MYO1E
cytoskeleton (GO:0005856) 2.554CD2AP, ANLN, ACTN4, MYO1E
extracellular organelle (GO:0043230) 1.894ACTN4, CRB2, CD2AP, MYO1E
vesicle (GO:0031982) 1.644ACTN4, CRB2, CD2AP, MYO1E
extracellular exosome (GO:0070062) 1.894CD2AP, CRB2, ACTN4, MYO1E
membrane (GO:0016020) 0.684CRB2, CD2AP, APOL1, TRPC6
membrane-bounded vesicle (GO:0031988) 1.714CD2AP, CRB2, ACTN4, MYO1E
cell-cell junction (GO:0005911) 3.854ACTN4, CD2AP, TRPC6, MYO1E
extracellular vesicle (GO:1903561) 1.894CD2AP, CRB2, ACTN4, MYO1E
cell junction (GO:0030054) 2.754ACTN4, CD2AP, TRPC6, MYO1E
actin cytoskeleton (GO:0015629) 4.394CD2AP, ANLN, ACTN4, MYO1E
integral component of membrane (GO:0016021) 1.143CRB2, APOL1, TRPC6
extracellular region (GO:0005576) 2.183CRB2, ACTN4, APOL1
nuclear part (GO:0044428) 1.553PAX2, CD2AP, ANLN
plasma membrane (GO:0005886) 1.393CRB2, CD2AP, TRPC6
membrane part (GO:0044425) 0.953CRB2, APOL1, TRPC6
perinuclear region of cytoplasm (GO:0048471) 3.353CD2AP, INF2, ACTN4
nucleus (GO:0005634) 1.073ANLN, ACTN4, PAX2
intrinsic component of membrane (GO:0031224) 1.133CRB2, APOL1, TRPC6
cluster of actin-based cell projections (GO:0098862) 5.542ACTN4, MYO1E
extracellular space (GO:0005615) 2.632ACTN4, APOL1
nucleolus (GO:0005730) 3.062PAX2, CD2AP
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122CD2AP, MYO1E
cytoplasmic vesicle (GO:0031410) 2.872CD2AP, MYO1E
anchoring junction (GO:0070161) 3.612ACTN4, MYO1E
endocytic vesicle (GO:0030139) 5.042CD2AP, MYO1E
brush border (GO:0005903) 5.682ACTN4, MYO1E
intracellular vesicle (GO:0097708) 2.862CD2AP, MYO1E
cell projection (GO:0042995) 2.472ACTN4, CD2AP
cell cortex part (GO:0044448) 5.012ANLN, ACTN4
adherens junction (GO:0005912) 3.662ACTN4, MYO1E

NET-GE enrichment

Term New enriched termICP valueGenes
cytoskeleton (GO:0005856) -2.550.022ACTN4, ANLN, CD2AP, MYO1E
membrane raft (GO:0045121) NEW4.180.024CD2AP, CRB2, ACTN4, TRPC6
actin cytoskeleton (GO:0015629) -4.390.012CD2AP, ANLN, ACTN4, MYO1E
cytoplasmic vesicle (GO:0031410) -2.870.048CRB2, ANLN, CD2AP, TRPC6, MYO1E, ACTN4
membrane region (GO:0098589) NEW3.950.043CRB2, ANLN, CD2AP, TRPC6, PAX2, MYO1E, ACTN4
cytoskeletal part (GO:0044430) -2.490.022CD2AP, ANLN, ACTN4, PAX2, MYO1E
cell-cell junction (GO:0005911) -3.850.001ACTN4, ANLN, CD2AP, MYO1E, TRPC6
synapse part (GO:0044456) NEW3.420.034ACTN4, ANLN, CD2AP, TRPC6, MYO1E