| Disease ID | Disease name | Source of annotation with ARHGEF6 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS309530 | MENTAL RETARDATION, NONSYNDROMIC, X-LINKED | ClinVar, OMIM | link to OMIM | 25 | THOC2, HCFC1, RPS6KA3, USP9X, MID2, RAB39B, KIAA2022, ZNF81, PAK3, IQSEC2, DLG3, TSPAN7, ZDHHC15, ZNF711, KIF4A, ACSL4, BRWD3, IL1RAPL1, GDI1, SYP, ARHGEF6, ARX, DDX3X, GRIA3, FTSJ1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pancreatic cancer | hsa05212 | 6.56 |
| Regulation of actin cytoskeleton | hsa04810 | 4.9 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 7.05 |
| Signalling by NGF | R-HSA-166520 | 4.23 |
| G alpha (12/13) signalling events | R-HSA-416482 | 6.75 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | R-HSA-446388 | 9.98 |
| Cell junction organization | R-HSA-446728 | 6.51 |
| Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
| Cell-Cell communication | R-HSA-1500931 | 5.87 |
| Rho GTPase cycle | R-HSA-194840 | 6.04 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 6.59 |
| Cell-extracellular matrix interactions | R-HSA-446353 | 8.81 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| NRAGE signals death through JNK | R-HSA-193648 | 7.49 |
| GO term | GO ID | GO IC |
|---|---|---|
| Rho guanyl-nucleotide exchange factor activity | GO:0005089 | 5.37 |
| Ras guanyl-nucleotide exchange factor activity | GO:0005088 | 4.31 |
| guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| GTPase activator activity | GO:0005096 | 4.11 |
| GTPase regulator activity | GO:0030695 | 4.01 |
| enzyme activator activity | GO:0008047 | 3.56 |
| protein binding | GO:0005515 | 0.46 |
| molecular function regulator | GO:0098772 | 2.51 |
| nucleoside-triphosphatase regulator activity | GO:0060589 | 3.92 |
| binding | GO:0005488 | 0.18 |