| Disease ID | Disease name | Source of annotation with PAK3 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS309530 | MENTAL RETARDATION, NONSYNDROMIC, X-LINKED | ClinVar, OMIM, HUMSAVAR | link to OMIM | 25 | THOC2, HCFC1, RPS6KA3, USP9X, MID2, RAB39B, KIAA2022, ZNF81, PAK3, IQSEC2, DLG3, TSPAN7, ZDHHC15, ZNF711, KIF4A, ACSL4, BRWD3, IL1RAPL1, GDI1, SYP, ARHGEF6, ARX, DDX3X, GRIA3, FTSJ1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Renal cell carcinoma | hsa05211 | 6.6 |
| T cell receptor signaling pathway | hsa04660 | 6.01 |
| Ras signaling pathway | hsa04014 | 4.9 |
| ErbB signaling pathway | hsa04012 | 6.15 |
| Focal adhesion | hsa04510 | 4.92 |
| Axon guidance | hsa04360 | 5.63 |
| Regulation of actin cytoskeleton | hsa04810 | 4.9 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Generation of second messenger molecules | R-HSA-202433 | 7.34 |
| Signaling by Robo receptor | R-HSA-376176 | 7.98 |
| Activation of Rac | R-HSA-428540 | 9.18 |
| Sema3A PAK dependent Axon repulsion | R-HSA-399954 | 8.98 |
| Immune System | R-HSA-168256 | 2.37 |
| Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Developmental Biology | R-HSA-1266738 | 3.48 |
| RHO GTPases activate PAKs | R-HSA-5627123 | 8.59 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.89 |
| Signaling by VEGF | R-HSA-194138 | 4.66 |
| CD28 co-stimulation | R-HSA-389356 | 7.98 |
| CD28 dependent Vav1 pathway | R-HSA-389359 | 9.4 |
| Costimulation by the CD28 family | R-HSA-388841 | 6.56 |
| TCR signaling | R-HSA-202403 | 6.64 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.06 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 4.7 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 6.54 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| EPH-Ephrin signaling | R-HSA-2682334 | 6.43 |
| Axon guidance | R-HSA-422475 | 3.93 |
| RHO GTPase Effectors | R-HSA-195258 | 4.94 |
| Ephrin signaling | R-HSA-3928664 | 8.73 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 8.59 |
| Semaphorin interactions | R-HSA-373755 | 6.92 |
| VEGFR2 mediated vascular permeability | R-HSA-5218920 | 8.28 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| SH3 domain binding | GO:0017124 | 4.98 |
| enzyme binding | GO:0019899 | 2.27 |
| small GTPase binding | GO:0031267 | 4.13 |
| GTPase binding | GO:0051020 | 4.05 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| nucleotide binding | GO:0000166 | 1.96 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| nucleoside binding | GO:0001882 | 2.21 |
| cation binding | GO:0043169 | 1.4 |
| receptor signaling protein activity | GO:0005057 | 4.76 |
| ion binding | GO:0043167 | 1.36 |
| protein serine/threonine kinase activity | GO:0004674 | 3.64 |
| transferase activity | GO:0016740 | 1.95 |
| protein serine/threonine/tyrosine kinase activity | GO:0004712 | 6.07 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| protein kinase activity | GO:0004672 | 3.27 |
| metal ion binding | GO:0046872 | 1.41 |
| ATP binding | GO:0005524 | 2.43 |
| kinase activity | GO:0016301 | 2.93 |
| Ras GTPase binding | GO:0017016 | 4.2 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| Rho GTPase binding | GO:0017048 | 5.36 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| MAP kinase kinase activity | GO:0004708 | 7.25 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| receptor signaling protein serine/threonine kinase activity | GO:0004702 | 5.23 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |
| protein domain specific binding | GO:0019904 | 3.32 |