| Disease ID | Disease name | Source of annotation with AXIN1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 114550 | HEPATOCELLULAR CARCINOMA | OMIM, HUMSAVAR | link to OMIM | 11 | CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1 |
| 607864 | CAUDAL DUPLICATION ANOMALY | OMIM | link to OMIM | 1 | AXIN1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 | 5.6 |
| Endometrial cancer | hsa05213 | 6.81 |
| Colorectal cancer | hsa05210 | 6.52 |
| Pathways in cancer | hsa05200 | 3.98 |
| Basal cell carcinoma | hsa05217 | 6.79 |
| Hippo signaling pathway | hsa04390 | 5.37 |
| Wnt signaling pathway | hsa04310 | 5.49 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 8.03 |
| Disease | R-HSA-1643685 | 3.33 |
| T41 mutants of beta-catenin aren't phosphorylated | R-HSA-5358752 | 9.08 |
| S45 mutants of beta-catenin aren't phosphorylated | R-HSA-5358751 | 9.08 |
| Beta-catenin phosphorylation cascade | R-HSA-196299 | 8.89 |
| AXIN missense mutants destabilize the destruction complex | R-HSA-5467340 | 9.18 |
| AXIN mutants destabilize the destruction complex, activating WNT signaling | R-HSA-4839735 | 9.18 |
| truncations of AMER1 destabilize the destruction complex | R-HSA-5467348 | 9.18 |
| Diseases of signal transduction | R-HSA-5663202 | 4.89 |
| degradation of AXIN | R-HSA-4641257 | 7.23 |
| AMER1 mutants destabilize the destruction complex | R-HSA-4839748 | 9.18 |
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| misspliced GSK3beta mutants stabilize beta-catenin | R-HSA-5339716 | 9.08 |
| S33 mutants of beta-catenin aren't phosphorylated | R-HSA-5358747 | 9.08 |
| S37 mutants of beta-catenin aren't phosphorylated | R-HSA-5358749 | 9.08 |
| Degradation of beta-catenin by the destruction complex | R-HSA-195253 | 6.64 |
| Signaling by WNT in cancer | R-HSA-4791275 | 7.89 |
| truncated APC mutants destabilize the destruction complex | R-HSA-4839744 | 9.18 |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | R-HSA-4839743 | 9.08 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
| APC truncation mutants have impaired AXIN binding | R-HSA-5467337 | 9.18 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| receptor signaling complex scaffold activity | GO:0030159 | 6.6 |
| enzyme binding | GO:0019899 | 2.27 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| enzyme activator activity | GO:0008047 | 3.56 |
| molecular function regulator | GO:0098772 | 2.51 |
| structural molecule activity | GO:0005198 | 3.1 |
| I-SMAD binding | GO:0070411 | 7.34 |
| identical protein binding | GO:0042802 | 2.63 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| GTPase activator activity | GO:0005096 | 4.11 |
| beta-catenin binding | GO:0008013 | 5.3 |
| SMAD binding | GO:0046332 | 5.45 |
| GTPase regulator activity | GO:0030695 | 4.01 |
| protein domain specific binding | GO:0019904 | 3.32 |
| nucleoside-triphosphatase regulator activity | GO:0060589 | 3.92 |
| protein kinase binding | GO:0019901 | 3.44 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| kinase binding | GO:0019900 | 3.32 |
| armadillo repeat domain binding | GO:0070016 | 7.17 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| protein complex scaffold | GO:0032947 | 5.5 |