Disease table of HEPATOCELLULAR CARCINOMA OMIM ID: 114550

Gene-disease associations table

GeneAssociated with HEPATOCELLULAR CARCINOMA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TP53ClinVar, OMIMHGNC link17p13.112114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
AXIN1OMIM, HUMSAVARHGNC link16p13.32114550, 607864
MTUS1HUMSAVARHGNC link8p221114550
CDKN3HUMSAVARHGNC link14q22.21114550
PIK3CAClinVar, OMIM, HUMSAVARHGNC link3q26.3211114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
CASP8OMIMHGNC link2q33.14114550, 607271, 211980, 114480
PDGFRLOMIMHGNC link8p222114550, 114500
CTNNB1ClinVar, OMIMHGNC link3p22.16114550, 155255, 167000, PS156200, 114500, 132600
METOMIM, HUMSAVARHGNC link7q31.26114550, 607278, PS209850, 605074, PS220290, 142340
APCOMIMHGNC link5q22.26114550, PS175100, 155255, 135290, 114500, 613659
IGF2RClinVar, OMIMHGNC link6q25.31114550

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
8p222PDGFRL, MTUS1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
8p222PDGFRL, MTUS1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
8p22PDGFRL, MTUS1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
8p2PDGFRL, MTUS1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
32PIK3CA, CTNNB1
82PDGFRL, MTUS1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TP53YES159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING13MET, TP53, CTNNB1
CTNNB1YES20PTGS2, BIRC5, PPARD, CHGA, TCF7, CLDN2, CCND1, GLCE, CD44, GLI2, NRCAM, RB1, MMP14, JUN, SPP1, VIM, MYC, PLD1, MMP7, STARD70
APCYES11PTGS2, NOS2, KLF4, BIRC5, SPP1, DNMT1, AKT1, MYC, AMHR2, ODC1, SGK10
YY1NO74FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A22APC, TP53
SIRT1NO43ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A2TP53, CTNNB1
EZH2NO31PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND12APC, TP53
SOX6NO6CDKN1A, CCND1, TP53, CDK4, CTNNB1, CCNA22TP53, CTNNB1
ETS1NO90PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD62AXIN1, TP53
STAT1NO79CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML2MET, TP53
USF2NO42PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC2APC, IGF2R
PAX5NO20XBP1, BAX, FCER2, LEF1, BLK, BCL2, MET, CCND1, RAG2, CDKN1A, TP53, PRDM1, RB1, CD79A, PRKCE, TIMP1, FHL2, MMP1, MYCN, CD192MET, TP53
ESR1NO68UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B2TP53, CTNNB1
YBX1NO29AR, RAD9A, MET, ANAPC4, CKS2, AGT, EGFR, SKP2, TYMS, FAS, SLC6A4, CXCR4, CCNC, ERBB2, ERBB3, RBBP8, E2F1, CDC20, CDKN3, TOP2A, CDH1, SUMO1, MMP2, KPNA2, ABCB1, MMP13, CCNB1, MNAT1, MYCN2MET, CDKN3
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TP53YES50ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN1TP53
AXIN1YES2SP100, ETS10
CDKN3YES1YBX10
PIK3CAYES1FOXO30
CASP8YES4RUNX3, MEN1, DNMT1, CREB10
CTNNB1YES8AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT11TP53
METYES13SP1, FOXP2, PAX3, SMAD7, TP53, SNAI2, HIF1A, MITF, SP3, YBX1, PAX5, PAX6, STAT11TP53
APCYES6YY1, USF2, CEBPZ, EZH2, CDX2, USF10
IGF2RYES1USF20
PTGS2NO41AR, ING4, TFAP2A, TCF7L2, CREB1, PGR, JUND, FOS, NFATC4, SP1, ETV4, STAT2, EGR1, STAT6, USF2, DR1, CTNNB1, HMGA1, PPARA, APC, EP300, HDAC1, STAT3, ATF2, JUN, RELA, HDAC4, SETBP1, NFKB1, STAT1, ELF3, NR0B2, CREBBP, NFIL3, CDX1, CEBPB, CEBPD, CDX2, JUNB, PPARG, USF12APC, CTNNB1
AKT1NO7APC, STAT3, GLI1, AR, TP53, RELA, NFKB12APC, TP53
DNMT1NO6SP1, APC, STAT3, NPM1, TP53, EP3002APC, TP53
SPP1NO23POU2F1, ETS2, TFCP2, TBX21, POU5F1, SP1, ETV4, CEBPA, FOXD3, ETS1, CTNNB1, HTATIP2, ESRRA, APC, LEF1, VDR, HDAC1, ERG, JUN, ING4, EP300, POU2F2, NR3C12APC, CTNNB1
MYCNO66E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A3APC, TP53, CTNNB1
BIRC5NO25ILF3, E2F4, TP53, TCF7L2, SP1, TCF4, NFKB1, KLF4, DNMT1, CTNNB1, FOXO3, APC, LEF1, HDAC1, RELA, EP300, E2F1, STAT3, SP4, EHMT2, RB1, SP3, TP73, KLF5, MYCN3APC, TP53, CTNNB1
CCND1NO62POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX62TP53, CTNNB1
RB1NO19KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX52TP53, CTNNB1
GLI2NO3SMAD3, TP53, CTNNB12TP53, CTNNB1
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TP53AXIN1Yes27CSNK1E, DAXX, TP53, CSNK1D, DVL2, PIN1, CARM1, TNFAIP3, HTT, MAP3K1, SMAD7, SKI, AXIN1, UTP14A, EEF1A1, HIPK2, FBXW11, SMURF1, CSNK1A1, PRMT1, GSK3B, BTRC, PPP1CA, UBC, MYC, PML, SMYD2
TP53MTUS1No3SPICE1, NINL, CLTC
TP53CDKN3No3CDK1, NCOA3, CDK2
TP53PIK3CANo16UFD1L, DDX5, ESR1, CRK, GSN, HRAS, PCBP1, WDR5, SMAD2, ATR, SMAD3, IRS4, DNAJB6, APPL1, HDAC1, SQSTM1
TP53CASP8Yes28TNFAIP3, TOPORS, BAX, TP53, VIM, CFLAR, HECTD3, CHUK, MAPK8, MAP1LC3B, PARK7, BLM, RNF34, BIRC6, CHD3, SQSTM1, CRYAB, SNRPD3, IKBKB, PTEN, PARP1, CASP8, BCL2, MAPK1, TSC22D3, YBX1, RB1, UBC
TP53CTNNB1No95DDX5, TRRAP, PIN1, HTT, RBBP5, FOXO3, KMT2A, ELAVL1, NR4A1, ABL1, UBE2B, EP400, RPLP2, HSPA1B, SKP1, SERBP1, PLK1, ESR1, KAT2B, HNRNPA1, HERC5, HSP90AB1, ASH2L, PTGS2, MAPK8, CARM1, DDB1, CCNA2, LMNA, SMURF1, SFN, HERC2, MAPK9, AURKA, HNRNPM, KLF5, HIF1A, HNRNPK, BTRC, CUL4A, ZBTB33, CHUK, IQGAP1, BCL6, TCF4, UCHL1, TUBA1A, CREB1, HNRNPA2B1, AXIN1, SMAD3, BRCA1, FBXW11, OBSL1, HDAC1, SMAD2, IKBKB, TFAP2A, PTEN, EP300, SMARCA4, MOV10, CDK2, MEN1, CCDC8, SIRT1, TADA3, HNF4A, KAT2A, FOXB1, CRYAB, ZIC3, RB1CC1, DVL2, RYK, CTBP1, MUC1, CEP128, PML, SMAD7, COPS5, TADA2A, YWHAZ, SP1, CHD8, SMARCA5, TOP2A, PARP1, GSK3B, HSPA8, CREBBP, HUWE1, NLK, UHRF2, RANBP2
TP53METNo10SPSB1, CRK, PCBP1, HSPA4, HSP90AA1, SOCS1, HSP90AB1, SRC, RANBP9, STUB1
TP53APCNo37CSNK1E, TFAP2A, BTRC, HSPA5, CTBP1, MUC1, CEP128, CSNK2B, PTK2, AXIN1, COPS5, RPA2, RPS27, SFN, FBXW11, ING5, HECTD1, ANXA7, RPGRIP1L, CSNK1A1, GIGYF2, TAF1, PCNA, RANBP9, GSK3B, CSNK2A1, CREBBP, MYO6, SENP1, LAMA4, TUBA4A, DVL2, HNRNPM, RANBP2, UBC, FLNA, PPP1R13B
TP53IGF2RNo7CHMP4B, CSNK2A1, SIRT7, ABCE1, CCDC8, ELAVL1, EWSR1
AXIN1CASP8No3UBC, TNFAIP3, TP53
AXIN1CTNNB1Yes23GSK3A, XPO1, CAV1, PIN1, BTRC, CTNNA1, APC, CARM1, HTT, PML, SMAD7, MAPRE1, AXIN1, DVL3, LRP6, SMURF1, JUP, AXIN2, GSK3B, AMER1, DVL1, DVL2, FBXW11
AXIN1METNo1CTNNB1
AXIN1APCYes19PPP2R5A, AMER1, CTNNA1, ARHGAP21, CSNK1E, DVL2, BTRC, XPO1, JUP, AXIN1, AXIN2, TNKS, CTNNB1, APC, UBC, CSNK1A1, GSK3B, MAPRE1, FBXW11
CDKN3CTNNB1No1CDK2
PIK3CACASP8No8IL13RA2, TNFRSF1A, FASLG, BEX1, UMPS, PSMC3IP, IL24, SQSTM1
PIK3CACTNNB1No10DDX5, AKT1, HDAC1, NOTCH1, SMAD2, PIK3R1, SMAD3, ESR1, NTRK1, CBL
PIK3CAMETNo4CRK, GRB2, PCBP1, CBL
PIK3CAAPCNo1IL24
CASP8CTNNB1No14CRYAB, MAPK8, FAS, IKBKB, FAF1, CASP3, PARP1, HDAC7, SOX2, PTEN, MSN, EZR, CUL3, CHUK
CASP8METNo1CASP3
CASP8APCNo6AGR3, TRAF1, IL24, ST14, UBC, CASC3
CTNNB1METYes6EGFR, CBL, CDH1, CASP3, HSP90AB1, LGALS9
CTNNB1APCYes32LATS2, DLGAP1, STRN3, XPO1, SIAH1, BTRC, CTBP1, MUC1, ERBB2IP, NHSL1, CEP128, MAPRE1, AXIN1, COPS5, CTNNA1, NUP153, FBXW11, APC, SFN, APC2, JUP, AXIN2, TFAP2A, AP2M1, EPAS1, GSK3B, AMER1, CREBBP, DVL2, HNRNPM, NUP98, RANBP2
CTNNB1IGF2RNo2ELAVL1, CCDC8
METAPCNo3HGS, RANBP9, CTNNB1
METIGF2RNo2FBXO6, GGA3
APCIGF2RNo1CSNK2A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TP53AXIN1Yes0
TP53CTNNB1No2CREBBP, EP300
CTNNB1APCNo1KCTD1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TP53AXIN1Yesactivation, binding28CSNK1E, CSNK1D, PIN1, LGALS3, KAT5, RPS27A, PRMT1, SUMO1, MAP3K1, SMAD7, SMAD3, HIPK2, CSNK1G2, UBA52, BTRC, CSNK1A1, UBC, AKT1, GSK3B, PSMD10, NOTCH1, PSME3, UBB, CAV1, PLK1, MAX, MYC, CSNK1G1
TP53CDKN3No-11PLK3, CDC25A, CDK2, PLK4, CDK1, PLK1, CDK4, CDK5, CDC20, CDK7, PLK2
TP53PIK3CAYesactivation, expression42BCL2L1, PTEN, MET, EPHB4, LYN, AGT, CREB1, EGFR, SP1, PRKCD, GSK3B, CCND1, PTK2, EPHA2, ERBB2, SMAD3, RAF1, NGFR, YWHAZ, HGF, AR, HRAS, EFNB1, NOTCH1, CDH1, SMAD2, AKT1, NTN1, VEGFA, NFKB1, STAT3, KRAS, NR3C1, PTPN11, BDNF, RELA, MTOR, SGK1, ESR1, MYC, IGF1R, ERBB4
TP53CTNNB1No-115AKT1, MMP9, EGFR, HDAC9, FOXO3, MYO6, HTT, PTK2, RBBP5, TFF2, DKK1, MAPK12, CABLES1, CA9, ELAVL1, CSNK1A1, JUN, SPN, EP400, SKP1, BTRC, MTOR, YWHAG, SFN, MYOG, KAT2B, BCL2L1, CSNK1E, YWHAE, EZH2, PLK1, ASH2L, PTGS2, MAPK8, HGF, HIC1, ABL1, SMARCA4, PKD1, NUMB, MAPK9, CDH1, MITF, IGF1R, HDAC2, TERT, MMP2, PSENEN, UBC, HIF1A, NME1, AR, SMAD4, CSNK1D, VCAN, KAT5, FOS, CDK5R1, MAPK11, GSK3B, CCND1, CUL4A, AXIN1, SMAD3, FOXO1, BRCA1, HIPK2, SIRT1, BIRC5, HSPB3, HDAC1, PSEN1, NOTCH1, SMAD2, MED1, VEGFA, EP300, MAPK14, FHL2, CDK2, CSNK2A1, RUNX3, HNF4A, PTPN11, FOXM1, MET, HSPB2-C11ORF52, SNAI1, XPO1, SNAI2, CTBP1, MUC1, RPS27A, BCL2, PML, SMAD7, PIK3CA, EPHA2, ERBB2, COPS5, YWHAZ, RUVBL1, ID2, TOP2A, BDNF, NANOG, NFKB1, STAT3, CREBBP, RELA, IKBKB, DSC3, MYC, KLF4, ERBB4
TP53METYesactivation, binding30AR, MDM2, MAPK3, PTPN11, C12ORF5, PIK3CA, EGFR, FGF2, MUC1, HSP90AA1, MAPK8, EGR1, IL6, PTK2, CD82, DNAJA3, HGF, HRAS, CDH1, TRAF6, MITF, VEGFA, ETS1, STAT3, TGFA, MAPK1, RB1, ITCH, UBC, HIF1A
AXIN1CDKN3No-1PLK1
AXIN1PIK3CANo-10NOTCH1, CDH2, CTNNB1, TP53, CTNND1, SMAD3, AKT1, MYC, GSK3B, CTNNA1
AXIN1CTNNB1Yesactivation, binding46FRAT1, TGFBR2, CSNK1E, FAM123B, LRP5, MDFIC, SIAH1, CSNK1D, PLK1, BTRC, AKT1, KAT5, CTNNA1, RPS27A, PPP2R5D, PROC, CACYBP, SMAD7, CSNK1A1L, SMAD3, WNT3A, CDH17, DVL3, HIPK2, FBXW11, PPP2R5A, GSK3A, DACT1, APC2, CSNK1A1, UBC, JUP, AXIN2, CDH2, GSK3B, FZD5, TGFBR1, DVL1, NOTCH1, PITX2, MAGI2, CTNND1, DVL2, LRP6, CTNNBIP1, MYC
AXIN1METNo-7SMURF1, CTNNB1, TP53, CTNND1, CDH2, UBC, CTNNA1
CDKN3PIK3CANo-0
CDKN3CTNNB1No-2CDK2, PLK1
PIK3CACTNNB1Yesactivation59MYC, BCL2L1, EGFR, MET, PRKCZ, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, RAP1A, RAP1B, VEGFA, CTNNA1, HGF, KDR, GSK3B, RHOA, ACTA1, PTK2, EPHA2, ERBB2, ERBB3, DLG1, SMAD2, SMAD3, YWHAZ, AKT2, IGF1, PRKCI, AR, PTPN1, NOTCH1, BDNF, SLC9A3R1, CDH1, AKT1, SRC, FYN, NFKB1, PRKCA, STAT3, GDNF, CDH2, RAC1, PTPN11, IGF1R, RELA, MTOR, PIK3R1, ERBB4, FLT3, EGF, GFRA1, EFNA1, FGFR1, CCND1, RAC3
PIK3CAMETYesactivation, binding55PLCG1, PGF, FIGF, RAC1, TP53, CTNND1, CDC42, RRAS, PIK3CG, PDGFB, ANGPT2, CRKL, GRB2, ANGPT1, KITLG, ITGA6, CDH2, CRK, PIK3R5, PTPN1, PTK2, CTNNA1, CTNNB1, SOS1, VEGFC, SHC1, PDGFA, HGF, AR, HRAS, S1PR1, CDH1, PIK3CB, GAB2, PIK3R3, SRC, CBLB, ITGB4, GAB1, STAT3, EGFR, PTPN11, ARF6, EFNA1, CBLC, INS, PIK3R1, CBL, IGF1, EGF, IRS1, PIK3CD, VEGFA, RHOA, BCAR1
PDGFRLMETNo-2PHLPP2, PHLPP1
CTNNB1METYesactivation, binding30RAC1, MITF, HGS, AR, CTNND1, CDC42, PIK3CA, EGFR, MUC1, MAPK8, RHOA, PIK3R1, PTK2, PTPRJ, CTNNA1, HGF, PTPN1, CDH1, UBC, CDH2, SRC, VEGFA, STAT3, PTPN11, FGF4, RAB5A, IGF1, EGF, EFNA1, HIF1A
CTNNB1IGF2RNo-1IGF2
METIGF2RNo-1PLAUR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
TP53AXIN1YesAxin-p53-HIPK2 complex;Daxx-Axin-p53 complex;DAXX-Axin-p53-HIPK2 complex3DAXX, HIPK2, TP53
TP53CTNNB1No-2AXIN1, EP300
TP53APCNo-1AXIN1
AXIN1CTNNB1YesAXIN-APC-betaCatenin-GSK3B complex;APC-Axin-1-beta-catenin complex;Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex3APC, PPP2R5A, GSK3B
AXIN1APCYesAXIN-APC-betaCatenin-GSK3B complex;APC-Axin-1-beta-catenin complex2GSK3B, CTNNB1
CTNNB1APCYesAXIN-APC-betaCatenin-GSK3B complex;APC-Axin-1-beta-catenin complex2AXIN1, GSK3B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
AXIN1CTNNB1No1APC
AXIN1APCYes2APC, AXIN1
CTNNB1APCYes2APC, CTNNB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.987APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
Endometrial cancerhsa052136.815APC, AXIN1, TP53, CTNNB1, PIK3CA
Colorectal cancerhsa052106.525APC, AXIN1, TP53, CTNNB1, PIK3CA
Signaling pathways regulating pluripotency of stem cellshsa045505.64APC, AXIN1, PIK3CA, CTNNB1
Proteoglycans in cancerhsa052055.024MET, TP53, CTNNB1, PIK3CA
MicroRNAs in cancerhsa052065.384APC, MET, PIK3CA, TP53
Basal cell carcinomahsa052176.794APC, AXIN1, TP53, CTNNB1
HTLV-I infectionhsa051664.594APC, TP53, PIK3CA, CTNNB1
Wnt signaling pathwayhsa043105.494APC, AXIN1, TP53, CTNNB1
Melanomahsa052186.563MET, TP53, PIK3CA
Bacterial invasion of epithelial cellshsa051006.343MET, PIK3CA, CTNNB1
Viral carcinogenesishsa052035.083CASP8, TP53, PIK3CA
Prostate cancerhsa052156.113TP53, PIK3CA, CTNNB1
Rap1 signaling pathwayhsa040154.973MET, PIK3CA, CTNNB1
Central carbon metabolism in cancerhsa052306.73MET, PIK3CA, TP53
Focal adhesionhsa045104.923MET, PIK3CA, CTNNB1
Apoptosishsa042106.233CASP8, TP53, PIK3CA
Hippo signaling pathwayhsa043905.373APC, AXIN1, CTNNB1
Thyroid hormone signaling pathwayhsa049195.823TP53, PIK3CA, CTNNB1
Hepatitis Bhsa051615.523CASP8, TP53, PIK3CA
PI3K-Akt signaling pathwayhsa041514.213MET, TP53, PIK3CA
Pancreatic cancerhsa052126.562TP53, PIK3CA
Renal cell carcinomahsa052116.62MET, PIK3CA
Thyroid cancerhsa052167.482TP53, CTNNB1
Gliomahsa052146.662TP53, PIK3CA
Leukocyte transendothelial migrationhsa046705.742PIK3CA, CTNNB1
Neurotrophin signaling pathwayhsa047225.782TP53, PIK3CA
Chagas disease (American trypanosomiasis)hsa051425.992CASP8, PIK3CA
Herpes simplex infectionhsa051685.082CASP8, TP53
Epstein-Barr virus infectionhsa051694.972TP53, PIK3CA
Toxoplasmosishsa051455.712CASP8, PIK3CA
Hepatitis Chsa051605.682TP53, PIK3CA
Measleshsa051625.62TP53, PIK3CA
Toll-like receptor signaling pathwayhsa046206.02CASP8, PIK3CA
Transcriptional misregulation in cancerhsa052025.212MET, TP53
Ras signaling pathwayhsa040144.92MET, PIK3CA
Non-small cell lung cancerhsa052236.882TP53, PIK3CA
Small cell lung cancerhsa052226.172TP53, PIK3CA
Chronic myeloid leukemiahsa052206.482TP53, PIK3CA
TNF signaling pathwayhsa046685.962CASP8, PIK3CA
p53 signaling pathwayhsa041156.562CASP8, TP53
Non-alcoholic fatty liver disease (NAFLD)hsa049325.512CASP8, PIK3CA
Regulation of actin cytoskeletonhsa048104.92APC, PIK3CA
Adherens junctionhsa045206.262MET, CTNNB1
Huntington's diseasehsa050165.172CASP8, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
Salmonella infection (hsa05132) NEW6.290.006TP53, CASP8, PIK3CA, CTNNB1
Shigellosis (hsa05131) NEW6.740.034CASP8, TP53, CTNNB1
FoxO signaling pathway (hsa04068) NEW5.630.044TP53, CASP8, PIK3CA, CTNNB1
Natural killer cell mediated cytotoxicity (hsa04650) NEW5.530.016CASP8, IGF2R, TP53, PIK3CA
Colorectal cancer (hsa05210) -6.520.0APC, AXIN1, TP53, CTNNB1, PIK3CA
Osteoclast differentiation (hsa04380) NEW5.640.025TP53, CASP8, PIK3CA, CTNNB1
Basal cell carcinoma (hsa05217) -6.790.0APC, AXIN1, TP53, CTNNB1
Prostate cancer (hsa05215) -6.110.02TP53, PIK3CA, CTNNB1
Central carbon metabolism in cancer (hsa05230) -6.70.023MET, PIK3CA, TP53
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.001APC, AXIN1, TP53, CTNNB1, PIK3CA
Cellular communityNEW3.570.024APC, MET, AXIN1, PIK3CA, CTNNB1
Chagas disease (American trypanosomiasis) (hsa05142) -5.990.008TP53, CASP8, PIK3CA, CTNNB1
Endometrial cancer (hsa05213) -6.810.0APC, AXIN1, TP53, CTNNB1, PIK3CA
Non-alcoholic fatty liver disease (NAFLD) (hsa04932) -5.510.021TP53, CASP8, PIK3CA, CTNNB1
Toxoplasmosis (hsa05145) -5.710.017TP53, CASP8, PIK3CA, CTNNB1
Apoptosis (hsa04210) -6.230.016CASP8, TP53, PIK3CA
HTLV-I infection (hsa05166) -4.590.023APC, TP53, PIK3CA, CTNNB1
Wnt signaling pathway (hsa04310) -5.490.002MET, APC, AXIN1, TP53, CTNNB1
Epithelial cell signaling in Helicobacter pylori infection (hsa05120) NEW6.580.001MET, CASP8, TP53, CTNNB1
Cancers: OverviewNEW2.720.002APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
Cancers: Specific typesNEW4.10.0APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
Bacterial invasion of epithelial cells (hsa05100) -6.340.05MET, PIK3CA, CTNNB1
Proteoglycans in cancer (hsa05205) -5.020.007MET, TP53, CTNNB1, PIK3CA
MicroRNAs in cancer (hsa05206) -5.380.003APC, MET, TP53, CTNNB1, PIK3CA
Toll-like receptor signaling pathway (hsa04620) -6.00.005TP53, CASP8, PIK3CA, CTNNB1
NOD-like receptor signaling pathway (hsa04621) NEW6.880.031CASP8, TP53, CTNNB1
RIG-I-like receptor signaling pathway (hsa04622) NEW6.620.034CASP8, TP53, CTNNB1
Pathways in cancer (hsa05200) -3.980.0APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
Signal transductionNEW2.060.036APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
Rap1 signaling pathway (hsa04015) -4.970.014MET, AXIN1, TP53, CTNNB1, PIK3CA
Non-small cell lung cancer (hsa05223) -6.880.029TP53, PIK3CA, CTNNB1
Viral carcinogenesis (hsa05203) -5.080.008MET, CASP8, TP53, CTNNB1, PIK3CA
TNF signaling pathway (hsa04668) -5.960.01TP53, CASP8, PIK3CA, CTNNB1
Thyroid hormone signaling pathway (hsa04919) -5.820.036TP53, PIK3CA, CTNNB1
Melanoma (hsa05218) -6.560.045MET, TP53, PIK3CA
Cellular ProcessesNEW2.220.001APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.786APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
Programmed Cell DeathR-HSA-53578015.654APC, CASP8, TP53, CTNNB1
ApoptosisR-HSA-1095815.684APC, CASP8, TP53, CTNNB1
DiseaseR-HSA-16436853.334APC, AXIN1, PIK3CA, CTNNB1
Diseases of signal transductionR-HSA-56632024.894APC, AXIN1, PIK3CA, CTNNB1
T41 mutants of beta-catenin aren't phosphorylatedR-HSA-53587529.083APC, AXIN1, CTNNB1
disassembly of the destruction complex and recruitment of AXIN to the membraneR-HSA-46412628.033APC, AXIN1, CTNNB1
S45 mutants of beta-catenin aren't phosphorylatedR-HSA-53587519.083APC, AXIN1, CTNNB1
misspliced GSK3beta mutants stabilize beta-cateninR-HSA-53397169.083APC, AXIN1, CTNNB1
S33 mutants of beta-catenin aren't phosphorylatedR-HSA-53587479.083APC, AXIN1, CTNNB1
S37 mutants of beta-catenin aren't phosphorylatedR-HSA-53587499.083APC, AXIN1, CTNNB1
Innate Immune SystemR-HSA-1682493.173CASP8, PIK3CA, CTNNB1
Signaling by WNT in cancerR-HSA-47912757.893APC, AXIN1, CTNNB1
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complexR-HSA-48397439.083APC, AXIN1, CTNNB1
Immune SystemR-HSA-1682562.373CASP8, PIK3CA, CTNNB1
Beta-catenin phosphorylation cascadeR-HSA-1962998.893APC, AXIN1, CTNNB1
Apoptotic execution phaseR-HSA-751537.283APC, CASP8, CTNNB1
Apoptotic cleavage of cellular proteinsR-HSA-1114657.733APC, CASP8, CTNNB1
Signaling by WntR-HSA-1957214.793APC, AXIN1, CTNNB1
Degradation of beta-catenin by the destruction complexR-HSA-1952536.643APC, AXIN1, CTNNB1
TCF dependent signaling in response to WNTR-HSA-2016815.363APC, AXIN1, CTNNB1
VEGFA-VEGFR2 PathwayR-HSA-44200974.72PIK3CA, CTNNB1
Signaling by VEGFR-HSA-1941384.662PIK3CA, CTNNB1
AMER1 mutants destabilize the destruction complexR-HSA-48397489.182APC, AXIN1
HemostasisR-HSA-1095823.982TP53, PIK3CA
Cell-Cell communicationR-HSA-15009315.872PIK3CA, CTNNB1
AXIN missense mutants destabilize the destruction complexR-HSA-54673409.182APC, AXIN1
AXIN mutants destabilize the destruction complex, activating WNT signalingR-HSA-48397359.182APC, AXIN1
truncated APC mutants destabilize the destruction complexR-HSA-48397449.182APC, AXIN1
deactivation of the beta-catenin transactivating complexR-HSA-37694027.592APC, CTNNB1
Intrinsic Pathway for ApoptosisR-HSA-1096067.732CASP8, TP53
APC truncation mutants have impaired AXIN bindingR-HSA-54673379.182APC, AXIN1
truncations of AMER1 destabilize the destruction complexR-HSA-54673489.182APC, AXIN1
Developmental BiologyR-HSA-12667383.482MET, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling by Interleukins (R-HSA-449147) NEW4.710.026APC, TP53, CASP8, PIK3CA, CTNNB1
Cell-Cell communication (R-HSA-1500931) -5.870.0MET, TP53, AXIN1, PIK3CA, CTNNB1
Programmed Cell Death (R-HSA-5357801) -5.650.015APC, CASP8, TP53, CTNNB1
deactivation of the beta-catenin transactivating complex (R-HSA-3769402) -7.590.0APC, AXIN1, TP53, CTNNB1
disassembly of the destruction complex and recruitment of AXIN to the membrane (R-HSA-4641262) -8.030.001APC, AXIN1, CTNNB1
T41 mutants of beta-catenin aren't phosphorylated (R-HSA-5358752) -9.080.0APC, AXIN1, CTNNB1
S45 mutants of beta-catenin aren't phosphorylated (R-HSA-5358751) -9.080.0APC, AXIN1, CTNNB1
Signalling by NGF (R-HSA-166520) NEW4.230.012APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
Apoptotic cleavage of cellular proteins (R-HSA-111465) -7.730.004APC, CASP8, CTNNB1
Beta-catenin phosphorylation cascade (R-HSA-196299) -8.890.0APC, AXIN1, CTNNB1
AXIN missense mutants destabilize the destruction complex (R-HSA-5467340) -9.180.023APC, AXIN1
AXIN mutants destabilize the destruction complex, activating WNT signaling (R-HSA-4839735) -9.180.023APC, AXIN1
truncations of AMER1 destabilize the destruction complex (R-HSA-5467348) -9.180.023APC, AXIN1
Vesicle-mediated transport (R-HSA-5653656) NEW4.330.043MET, AXIN1, IGF2R, TP53, CTNNB1
Diseases of signal transduction (R-HSA-5663202) -4.890.016APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) NEW4.510.003APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
misspliced GSK3beta mutants stabilize beta-catenin (R-HSA-5339716) -9.080.0APC, AXIN1, CTNNB1
Apoptotic execution phase (R-HSA-75153) -7.280.01APC, CASP8, CTNNB1
APC truncation mutants have impaired AXIN binding (R-HSA-5467337) -9.180.023APC, AXIN1
S33 mutants of beta-catenin aren't phosphorylated (R-HSA-5358747) -9.080.0APC, AXIN1, CTNNB1
S37 mutants of beta-catenin aren't phosphorylated (R-HSA-5358749) -9.080.0APC, AXIN1, CTNNB1
Degradation of beta-catenin by the destruction complex (R-HSA-195253) -6.640.032APC, AXIN1, CTNNB1
Signaling by WNT in cancer (R-HSA-4791275) -7.890.001APC, AXIN1, CTNNB1
truncated APC mutants destabilize the destruction complex (R-HSA-4839744) -9.180.023APC, AXIN1
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex (R-HSA-4839743) -9.080.0APC, AXIN1, CTNNB1
AMER1 mutants destabilize the destruction complex (R-HSA-4839748) -9.180.023APC, AXIN1
Apoptosis (R-HSA-109581) -5.680.014APC, CASP8, TP53, CTNNB1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189APC, CASP8, MET, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
protein binding (GO:0005515) 0.469APC, CASP8, MET, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
enzyme binding (GO:0019899) 2.277APC, CASP8, MET, IGF2R, TP53, AXIN1, CTNNB1
catalytic activity (GO:0003824) 1.056CASP8, MET, PDGFRL, IGF2R, PIK3CA, CDKN3
signal transducer activity (GO:0004871) 2.286CASP8, MET, PDGFRL, IGF2R, AXIN1, CTNNB1
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.775MET, PDGFRL, IGF2R, PIK3CA, CDKN3
transferase activity (GO:0016740) 1.955MET, PDGFRL, IGF2R, PIK3CA, CDKN3
kinase activity (GO:0016301) 2.935MET, PDGFRL, IGF2R, PIK3CA, CDKN3
small molecule binding (GO:0036094) 1.894MET, IGF2R, PIK3CA, TP53
carbohydrate derivative binding (GO:0097367) 2.034MET, IGF2R, TP53, PIK3CA
organic cyclic compound binding (GO:0097159) 1.054MET, TP53, PIK3CA, CTNNB1
protein kinase binding (GO:0019901) 3.444APC, AXIN1, TP53, CTNNB1
kinase binding (GO:0019900) 3.324APC, AXIN1, TP53, CTNNB1
macromolecular complex binding (GO:0044877) 2.614APC, CASP8, TP53, CTNNB1
protein kinase activity (GO:0004672) 3.274MET, PDGFRL, IGF2R, PIK3CA
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.084MET, PDGFRL, IGF2R, PIK3CA
heterocyclic compound binding (GO:1901363) 1.064MET, TP53, PIK3CA, CTNNB1
identical protein binding (GO:0042802) 2.634AXIN1, IGF2R, CASP8, TP53
ubiquitin-like protein ligase binding (GO:0044389) 4.153AXIN1, CASP8, TP53
purine ribonucleoside triphosphate binding (GO:0035639) 2.223MET, PIK3CA, TP53
molecular transducer activity (GO:0060089) 2.323MET, PDGFRL, IGF2R
receptor activity (GO:0004872) 2.323MET, PDGFRL, IGF2R
purine nucleoside binding (GO:0001883) 2.223MET, TP53, PIK3CA
signaling receptor activity (GO:0038023) 2.493MET, PDGFRL, IGF2R
molecular function regulator (GO:0098772) 2.513APC, AXIN1, PIK3CA
nucleoside phosphate binding (GO:1901265) 1.963MET, TP53, PIK3CA
nucleoside binding (GO:0001882) 2.213MET, TP53, PIK3CA
nucleotide binding (GO:0000166) 1.963MET, PIK3CA, TP53
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.553MET, PDGFRL, IGF2R
protein tyrosine kinase activity (GO:0004713) 4.543MET, PDGFRL, IGF2R
ribonucleoside binding (GO:0032549) 2.223MET, PIK3CA, TP53
protein complex binding (GO:0032403) 3.093APC, CASP8, CTNNB1
purine nucleotide binding (GO:0017076) 2.193MET, PIK3CA, TP53
ATP binding (GO:0005524) 2.433MET, PIK3CA, TP53
enzyme regulator activity (GO:0030234) 2.853APC, AXIN1, PIK3CA
protein phosphatase binding (GO:0019903) 4.933MET, TP53, CTNNB1
phosphatase binding (GO:0019902) 4.633MET, TP53, CTNNB1
ubiquitin protein ligase binding (GO:0031625) 4.173AXIN1, CASP8, TP53
adenyl nucleotide binding (GO:0030554) 2.43MET, TP53, PIK3CA
transmembrane signaling receptor activity (GO:0004888) 2.573MET, PDGFRL, IGF2R
adenyl ribonucleotide binding (GO:0032559) 2.413MET, PIK3CA, TP53
ribonucleotide binding (GO:0032553) 2.193MET, PIK3CA, TP53
purine ribonucleotide binding (GO:0032555) 2.23MET, PIK3CA, TP53
receptor binding (GO:0005102) 2.433CASP8, TP53, CTNNB1
transmembrane receptor protein kinase activity (GO:0019199) 5.323MET, PDGFRL, IGF2R
purine ribonucleoside binding (GO:0032550) 2.223MET, PIK3CA, TP53
transmembrane receptor activity (GO:0099600) 2.533MET, PDGFRL, IGF2R
kinase regulator activity (GO:0019207) 4.52APC, PIK3CA
nucleic acid binding transcription factor activity (GO:0001071) 2.652TP53, CTNNB1
nucleic acid binding (GO:0003676) 1.442TP53, CTNNB1
DNA binding (GO:0003677) 1.922TP53, CTNNB1
G-protein coupled receptor activity (GO:0004930) 2.952PDGFRL, IGF2R
ion binding (GO:0043167) 1.362IGF2R, TP53
I-SMAD binding (GO:0070411) 7.342AXIN1, CTNNB1
double-stranded DNA binding (GO:0003690) 3.092TP53, CTNNB1
hydrolase activity (GO:0016787) 1.92CASP8, CDKN3
protein kinase regulator activity (GO:0019887) 4.62APC, PIK3CA
transcription factor binding (GO:0008134) 3.462TP53, CTNNB1
regulatory region nucleic acid binding (GO:0001067) 3.032TP53, CTNNB1
beta-catenin binding (GO:0008013) 5.32APC, AXIN1
SMAD binding (GO:0046332) 5.452AXIN1, CTNNB1
protein domain specific binding (GO:0019904) 3.322AXIN1, CASP8
cell adhesion molecule binding (GO:0050839) 4.52APC, CTNNB1
RNA polymerase II transcription factor binding (GO:0001085) 5.082TP53, CTNNB1
transcription regulatory region DNA binding (GO:0044212) 3.032TP53, CTNNB1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652TP53, CTNNB1
cadherin binding (GO:0045296) 6.412APC, CTNNB1
regulatory region DNA binding (GO:0000975) 3.032TP53, CTNNB1
protein dimerization activity (GO:0046983) 2.722AXIN1, TP53
chromatin binding (GO:0003682) 3.642TP53, CTNNB1
enzyme activator activity (GO:0008047) 3.562AXIN1, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
serine-type endopeptidase activity (GO:0004252) NEW4.40.001APC, CASP8, IGF2R, TP53, CTNNB1
small conjugating protein ligase binding (GO:0044389) -4.150.021APC, AXIN1, CASP8, TP53, CTNNB1
kinase regulator activity (GO:0019207) -4.50.026MET, APC, PIK3CA, TP53
phosphatase regulator activity (GO:0019208) NEW5.260.039TP53, PIK3CA, CTNNB1
enzyme binding (GO:0019899) -2.270.0APC, CASP8, MET, IGF2R, TP53, AXIN1, CTNNB1
molecular transducer activity (GO:0060089) -2.320.038CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
enzyme activator activity (GO:0008047) -3.560.001APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
signal transducer activity (GO:0004871) -2.280.038CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
signaling receptor activity (GO:0038023) -2.490.007CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
enzyme inhibitor activity (GO:0004857) NEW3.780.005APC, CASP8, MET, PIK3CA, TP53, CTNNB1
cysteine-type peptidase activity (GO:0008234) NEW4.510.016APC, AXIN1, CASP8, TP53
small conjugating protein-specific protease activity (GO:0019783) NEW4.970.015APC, AXIN1, TP53
transmembrane receptor protein tyrosine kinase activity (GO:0004714) -5.550.001MET, PDGFRL, IGF2R
cysteine-type endopeptidase regulator activity involved in apoptotic process (GO:0043028) NEW6.020.01CASP8, TP53, CTNNB1
transferase activity (GO:0016740) -1.950.002APC, CASP8, MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
R-SMAD binding (GO:0070412) NEW6.650.011AXIN1, CTNNB1
protein tyrosine kinase activity (GO:0004713) -4.540.012MET, AXIN1, IGF2R, PDGFRL, TP53
I-SMAD binding (GO:0070411) -7.340.016AXIN1, CTNNB1
protein kinase activity (GO:0004672) -3.270.0MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
microtubule binding (GO:0008017) NEW4.420.033APC, AXIN1, TP53, CTNNB1
calcium ion binding (GO:0005509) NEW3.170.014APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
protein kinase regulator activity (GO:0019887) -4.60.013APC, MET, PIK3CA, TP53
transcription factor binding (GO:0008134) -3.460.01CASP8, MET, IGF2R, TP53, AXIN1, CTNNB1
kinase activity (GO:0016301) -2.930.0CASP8, MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
GTPase activator activity (GO:0005096) NEW4.110.005APC, AXIN1, TP53, CTNNB1, PIK3CA
beta-catenin binding (GO:0008013) -5.30.029APC, AXIN1, CTNNB1
SMAD binding (GO:0046332) -5.450.022AXIN1, TP53, CTNNB1
kinase binding (GO:0019900) -3.320.024APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
protein phosphatase binding (GO:0019903) -4.930.003MET, TP53, CTNNB1
phosphatase binding (GO:0019902) -4.630.0MET, TP53, AXIN1, PIK3CA, CTNNB1
protein domain specific binding (GO:0019904) -3.320.01APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
nucleoside-triphosphatase regulator activity (GO:0060589) NEW3.920.001APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
protein kinase binding (GO:0019901) -3.440.011APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
ubiquitin protein ligase binding (GO:0031625) -4.170.021APC, AXIN1, CASP8, TP53, CTNNB1
GTPase regulator activity (GO:0030695) NEW4.010.001APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
phosphotransferase activity, alcohol group as acceptor (GO:0016773) -3.080.0CASP8, MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772) -2.770.0CASP8, MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
gamma-catenin binding (GO:0045295) NEW7.170.023APC, CTNNB1
transmembrane signaling receptor activity (GO:0004888) -2.570.003CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
peptidase activity, acting on L-amino acid peptides (GO:0070011) NEW3.260.003APC, CASP8, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
armadillo repeat domain binding (GO:0070016) NEW7.170.014AXIN1, CTNNB1
peptidase activity (GO:0008233) NEW3.230.004APC, CASP8, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
transmembrane receptor protein kinase activity (GO:0019199) -5.320.003MET, PDGFRL, IGF2R, TP53
ribonucleotide binding (GO:0032553) -2.190.021APC, CASP8, MET, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
receptor activity (GO:0004872) -2.320.029CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.3910APC, CASP8, MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of biological process (GO:0050789) 0.4510APC, CASP8, MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of cellular process (GO:0050794) 0.510APC, CASP8, MET, PDGFRL, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
signal transduction (GO:0007165) 1.289APC, CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
single-organism process (GO:0044699) 0.489APC, CASP8, MET, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
developmental process (GO:0032502) 1.368APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
primary metabolic process (GO:0044238) 0.698APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of primary metabolic process (GO:0080090) 1.088APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of metabolic process (GO:0019222) 1.028APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
protein metabolic process (GO:0019538) 1.458APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of macromolecule metabolic process (GO:0060255) 1.088APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
cellular process (GO:0009987) 0.268APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of cellular metabolic process (GO:0031323) 1.078APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
macromolecule metabolic process (GO:0043170) 0.838APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
single-organism developmental process (GO:0044767) 1.498APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
organic substance metabolic process (GO:0071704) 0.638APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
single-organism cellular process (GO:0044763) 0.658APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
cell surface receptor signaling pathway (GO:0007166) 2.098APC, CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, CTNNB1
positive regulation of biological process (GO:0048518) 1.28APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
negative regulation of biological process (GO:0048519) 1.338APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
metabolic process (GO:0008152) 0.588APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
negative regulation of cellular process (GO:0048523) 1.418APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
positive regulation of cellular process (GO:0048522) 1.38APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
multicellular organismal process (GO:0032501) 1.457APC, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of metabolic process (GO:0009893) 1.747APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
cellular macromolecule metabolic process (GO:0044260) 0.937APC, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of response to stimulus (GO:0048583) 1.547APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
response to stimulus (GO:0050896) 1.227APC, CASP8, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of catalytic activity (GO:0050790) 1.977APC, CASP8, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of protein metabolic process (GO:0051246) 1.937APC, CASP8, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
cellular metabolic process (GO:0044237) 0.697APC, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of programmed cell death (GO:0043067) 2.497APC, CASP8, MET, IGF2R, PIK3CA, TP53, CTNNB1
regulation of cellular protein metabolic process (GO:0032268) 1.997APC, CASP8, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
cellular component organization (GO:0016043) 1.247APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
response to chemical (GO:0042221) 1.987APC, CASP8, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of molecular function (GO:0065009) 1.787APC, CASP8, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of cell death (GO:0010941) 2.437APC, CASP8, MET, IGF2R, PIK3CA, TP53, CTNNB1
single-multicellular organism process (GO:0044707) 1.787APC, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
cellular component organization or biogenesis (GO:0071840) 1.227APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of macromolecule metabolic process (GO:0010604) 1.817APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of phosphorylation (GO:0042325) 2.56APC, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
cellular response to stimulus (GO:0051716) 1.976APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of response to stimulus (GO:0048584) 2.186CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of phosphate metabolic process (GO:0019220) 2.356APC, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of cell communication (GO:0010646) 1.736APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
regulation of signal transduction (GO:0009966) 1.846APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
cellular developmental process (GO:0048869) 1.826APC, CASP8, MET, TP53, AXIN1, CTNNB1
positive regulation of cellular metabolic process (GO:0031325) 1.816CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
anatomical structure development (GO:0048856) 1.586APC, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of protein metabolic process (GO:0051247) 2.436APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
regulation of transferase activity (GO:0051338) 2.886APC, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of protein phosphorylation (GO:0001932) 2.576APC, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of phosphorus metabolic process (GO:0051174) 2.356APC, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of protein modification process (GO:0031399) 2.326APC, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of nitrogen compound metabolic process (GO:0051171) 1.366APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
cellular response to chemical stimulus (GO:0070887) 2.576APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
regulation of signaling (GO:0023051) 1.726APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
regulation of localization (GO:0032879) 1.946APC, CASP8, MET, TP53, AXIN1, CTNNB1
regulation of apoptotic process (GO:0042981) 2.56APC, CASP8, IGF2R, PIK3CA, TP53, CTNNB1
response to organic substance (GO:0010033) 2.26APC, CASP8, IGF2R, PIK3CA, AXIN1, CTNNB1
cellular component assembly (GO:0022607) 2.145APC, AXIN1, CASP8, TP53, CTNNB1
negative regulation of metabolic process (GO:0009892) 1.935APC, AXIN1, CASP8, TP53, CTNNB1
macromolecular complex subunit organization (GO:0043933) 2.145APC, AXIN1, CASP8, TP53, CTNNB1
negative regulation of response to stimulus (GO:0048585) 2.525APC, MET, AXIN1, CASP8, CTNNB1
negative regulation of cellular metabolic process (GO:0031324) 2.015APC, AXIN1, CASP8, TP53, CTNNB1
positive regulation of cell death (GO:0010942) 3.325APC, CASP8, IGF2R, TP53, CTNNB1
macromolecular complex assembly (GO:0065003) 2.555APC, AXIN1, CASP8, TP53, CTNNB1
negative regulation of macromolecule metabolic process (GO:0010605) 2.015APC, AXIN1, CASP8, TP53, CTNNB1
protein complex subunit organization (GO:0071822) 2.65APC, AXIN1, CASP8, TP53, CTNNB1
positive regulation of apoptotic process (GO:0043065) 3.385APC, CASP8, IGF2R, TP53, CTNNB1
cellular response to organic substance (GO:0071310) 2.785APC, AXIN1, CASP8, PIK3CA, CTNNB1
positive regulation of cellular protein metabolic process (GO:0032270) 2.495TP53, CASP8, PIK3CA, CTNNB1, AXIN1
proteolysis (GO:0006508) 2.735APC, AXIN1, CASP8, TP53, CTNNB1
negative regulation of programmed cell death (GO:0043069) 3.025MET, CASP8, TP53, CTNNB1, PIK3CA
positive regulation of programmed cell death (GO:0043068) 3.385APC, CASP8, IGF2R, TP53, CTNNB1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435MET, AXIN1, TP53, CTNNB1, PIK3CA
negative regulation of cell death (GO:0060548) 2.955MET, CASP8, TP53, CTNNB1, PIK3CA
protein complex assembly (GO:0006461) 2.785APC, AXIN1, CASP8, TP53, CTNNB1
cellular component disassembly (GO:0022411) 3.525APC, AXIN1, CASP8, PIK3CA, CTNNB1
regulation of intracellular signal transduction (GO:1902531) 2.315CASP8, TP53, AXIN1, PIK3CA, CTNNB1
response to oxygen-containing compound (GO:1901700) 2.575APC, IGF2R, CASP8, CTNNB1, PIK3CA
proteolysis involved in cellular protein catabolic process (GO:0051603) 3.595APC, AXIN1, CASP8, TP53, CTNNB1
regulation of gene expression (GO:0010468) 1.375MET, AXIN1, TP53, CTNNB1, PIK3CA
positive regulation of cellular component organization (GO:0051130) 2.684APC, CASP8, TP53, CTNNB1
regulation of kinase activity (GO:0043549) 3.074APC, AXIN1, PIK3CA, CDKN3
regulation of cellular localization (GO:0060341) 3.034AXIN1, CASP8, TP53, CTNNB1
positive regulation of biosynthetic process (GO:0009891) 2.294MET, AXIN1, TP53, CTNNB1
regulation of transport (GO:0051049) 2.244AXIN1, CASP8, TP53, CTNNB1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294MET, AXIN1, TP53, CTNNB1
regulation of cellular component organization (GO:0051128) 2.014APC, CASP8, TP53, CTNNB1
regulation of cellular protein localization (GO:1903827) 3.434AXIN1, CASP8, TP53, CTNNB1
negative regulation of signaling (GO:0023057) 2.654APC, AXIN1, CASP8, CTNNB1
positive regulation of gene expression (GO:0010628) 2.354MET, AXIN1, TP53, CTNNB1
positive regulation of cellular biosynthetic process (GO:0031328) 2.34MET, AXIN1, TP53, CTNNB1
negative regulation of cell communication (GO:0010648) 2.664APC, AXIN1, CASP8, CTNNB1
enzyme linked receptor protein signaling pathway (GO:0007167) 3.244MET, PDGFRL, IGF2R, PIK3CA
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.544MET, PDGFRL, IGF2R, PIK3CA
modification-dependent macromolecule catabolic process (GO:0043632) 3.694APC, AXIN1, TP53, CTNNB1
regulation of cell differentiation (GO:0045595) 2.424APC, AXIN1, CASP8, CTNNB1
positive regulation of cell communication (GO:0010647) 2.414AXIN1, CASP8, TP53, CTNNB1
positive regulation of catalytic activity (GO:0043085) 2.44AXIN1, CASP8, PIK3CA, CTNNB1
regulation of protein localization (GO:0032880) 2.884AXIN1, CASP8, TP53, CTNNB1
cellular protein metabolic process (GO:0044267) 1.634MET, TP53, PIK3CA, CDKN3
organic substance catabolic process (GO:1901575) 2.454APC, AXIN1, TP53, CTNNB1
cellular macromolecule catabolic process (GO:0044265) 3.194APC, AXIN1, TP53, CTNNB1
negative regulation of cell cycle (GO:0045786) 3.674APC, TP53, CTNNB1, CDKN3
negative regulation of signal transduction (GO:0009968) 2.754APC, AXIN1, CASP8, CTNNB1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244MET, AXIN1, TP53, CTNNB1
positive regulation of signal transduction (GO:0009967) 2.54AXIN1, CASP8, TP53, CTNNB1
positive regulation of phosphorus metabolic process (GO:0010562) 2.784TP53, AXIN1, PIK3CA, CTNNB1
regulation of organelle organization (GO:0033043) 2.724APC, CASP8, TP53, CTNNB1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464MET, AXIN1, TP53, CTNNB1
single-organism organelle organization (GO:1902589) 2.684AXIN1, CASP8, TP53, PIK3CA
macromolecule catabolic process (GO:0009057) 3.04APC, AXIN1, TP53, CTNNB1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564MET, AXIN1, TP53, CTNNB1
negative regulation of apoptotic process (GO:0043066) 3.044TP53, CASP8, PIK3CA, CTNNB1
positive regulation of molecular function (GO:0044093) 2.234AXIN1, CASP8, PIK3CA, CTNNB1
regulation of cellular biosynthetic process (GO:0031326) 1.384MET, AXIN1, TP53, CTNNB1
regulation of biological quality (GO:0065008) 1.684TP53, CASP8, PIK3CA, CTNNB1
regulation of cell proliferation (GO:0042127) 2.414APC, TP53, CDKN3, CTNNB1
negative regulation of cell proliferation (GO:0008285) 3.264APC, TP53, CTNNB1, CDKN3
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354MET, AXIN1, TP53, CTNNB1
positive regulation of phosphate metabolic process (GO:0045937) 2.784TP53, AXIN1, PIK3CA, CTNNB1
animal organ development (GO:0048513) 2.534APC, IGF2R, PIK3CA, CTNNB1
regulation of protein kinase activity (GO:0045859) 3.154APC, AXIN1, PIK3CA, CDKN3
regulation of biosynthetic process (GO:0009889) 1.374MET, AXIN1, TP53, CTNNB1
cellular protein modification process (GO:0006464) 1.794MET, TP53, CDKN3, PIK3CA
macromolecule modification (GO:0043412) 1.734MET, TP53, CDKN3, PIK3CA
protein modification process (GO:0036211) 1.794MET, TP53, PIK3CA, CDKN3
regulation of nucleic acid-templated transcription (GO:1903506) 1.554MET, AXIN1, TP53, CTNNB1
positive regulation of transcription, DNA-templated (GO:0045893) 2.564MET, AXIN1, TP53, CTNNB1
regulation of multicellular organismal process (GO:0051239) 1.874MET, CASP8, PIK3CA, CTNNB1
regulation of RNA biosynthetic process (GO:2001141) 1.554MET, AXIN1, TP53, CTNNB1
modification-dependent protein catabolic process (GO:0019941) 3.714APC, AXIN1, TP53, CTNNB1
positive regulation of intracellular signal transduction (GO:1902533) 2.954AXIN1, CASP8, TP53, CTNNB1
catabolic process (GO:0009056) 2.384APC, AXIN1, TP53, CTNNB1
localization (GO:0051179) 1.44TP53, IGF2R, PIK3CA, CTNNB1
positive regulation of signaling (GO:0023056) 2.414AXIN1, CASP8, TP53, CTNNB1
locomotion (GO:0040011) 2.914MET, APC, PIK3CA, CTNNB1
cellular catabolic process (GO:0044248) 2.624APC, AXIN1, TP53, CTNNB1
positive regulation of phosphorylation (GO:0042327) 2.94TP53, AXIN1, PIK3CA, CTNNB1
organelle organization (GO:0006996) 2.024AXIN1, CASP8, TP53, PIK3CA
regulation of cell cycle (GO:0051726) 2.934APC, TP53, CTNNB1, CDKN3
positive regulation of protein modification process (GO:0031401) 2.74TP53, AXIN1, PIK3CA, CTNNB1
proteasomal protein catabolic process (GO:0010498) 4.124APC, AXIN1, TP53, CTNNB1
positive regulation of RNA metabolic process (GO:0051254) 2.514MET, AXIN1, TP53, CTNNB1
positive regulation of RNA biosynthetic process (GO:1902680) 2.544MET, AXIN1, TP53, CTNNB1
regulation of transcription, DNA-templated (GO:0006355) 1.564MET, AXIN1, TP53, CTNNB1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394MET, AXIN1, TP53, CTNNB1
regulation of macromolecule biosynthetic process (GO:0010556) 1.434MET, AXIN1, TP53, CTNNB1
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 4.164APC, AXIN1, TP53, CTNNB1
ubiquitin-dependent protein catabolic process (GO:0006511) 3.724APC, AXIN1, TP53, CTNNB1
regulation of RNA metabolic process (GO:0051252) 1.524MET, AXIN1, TP53, CTNNB1
positive regulation of protein phosphorylation (GO:0001934) 2.954TP53, AXIN1, PIK3CA, CTNNB1
protein catabolic process (GO:0030163) 3.934APC, AXIN1, TP53, CTNNB1
regulation of apoptotic signaling pathway (GO:2001233) 3.833CASP8, TP53, CTNNB1
regulation of neuron apoptotic process (GO:0043523) 4.473TP53, PIK3CA, CTNNB1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.793APC, AXIN1, CTNNB1
mitochondrion organization (GO:0007005) 3.693CASP8, TP53, PIK3CA
negative regulation of molecular function (GO:0044092) 2.743APC, CASP8, TP53
regulation of DNA metabolic process (GO:0051052) 3.873TP53, PIK3CA, CTNNB1
single organism reproductive process (GO:0044702) 2.733IGF2R, CASP8, CTNNB1
cell migration (GO:0016477) 3.123APC, PIK3CA, CTNNB1
vesicle-mediated transport (GO:0016192) 2.723IGF2R, PIK3CA, CTNNB1
response to external stimulus (GO:0009605) 2.553CASP8, TP53, CTNNB1
cell motility (GO:0048870) 3.023APC, PIK3CA, CTNNB1
Wnt signaling pathway (GO:0016055) 3.883APC, AXIN1, CTNNB1
positive regulation of organelle organization (GO:0010638) 3.383CASP8, TP53, CTNNB1
immune system process (GO:0002376) 2.293CASP8, PIK3CA, CTNNB1
negative regulation of biosynthetic process (GO:0009890) 2.473AXIN1, TP53, CTNNB1
regulation of establishment of protein localization (GO:0070201) 3.023AXIN1, CASP8, TP53
movement of cell or subcellular component (GO:0006928) 2.613APC, PIK3CA, CTNNB1
negative regulation of gene expression (GO:0010629) 2.483AXIN1, TP53, CTNNB1
intracellular signal transduction (GO:0035556) 2.393CASP8, TP53, PIK3CA
regulation of protein serine/threonine kinase activity (GO:0071900) 3.583APC, AXIN1, CDKN3
organic substance biosynthetic process (GO:1901576) 1.343TP53, PIK3CA, CTNNB1
regulation of mitotic cell cycle (GO:0007346) 3.713APC, TP53, CTNNB1
positive regulation of transferase activity (GO:0051347) 3.313AXIN1, PIK3CA, CTNNB1
regulation of immune system process (GO:0002682) 2.53CASP8, PIK3CA, CTNNB1
cellular response to abiotic stimulus (GO:0071214) 4.153CASP8, TP53, CTNNB1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013AXIN1, PIK3CA, CTNNB1
beta-catenin destruction complex disassembly (GO:1904886) 6.643APC, AXIN1, CTNNB1
regulation of developmental process (GO:0050793) 2.13CASP8, PIK3CA, CTNNB1
transport (GO:0006810) 1.513IGF2R, PIK3CA, CTNNB1
cell cycle arrest (GO:0007050) 4.693APC, TP53, CDKN3
canonical Wnt signaling pathway (GO:0060070) 5.263APC, AXIN1, CTNNB1
cell activation (GO:0001775) 3.473CASP8, PIK3CA, CTNNB1
regulation of neuron death (GO:1901214) 4.193TP53, PIK3CA, CTNNB1
establishment of localization (GO:0051234) 1.483IGF2R, PIK3CA, CTNNB1
regulation of hydrolase activity (GO:0051336) 2.533AXIN1, CASP8, TP53
programmed cell death (GO:0012501) 3.13AXIN1, CASP8, TP53
regulation of response to stress (GO:0080134) 2.533MET, AXIN1, CASP8
response to stress (GO:0006950) 1.83APC, CASP8, TP53
response to alcohol (GO:0097305) 4.583APC, CASP8, CTNNB1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533AXIN1, TP53, CTNNB1
regulation of chromosome organization (GO:0033044) 4.113APC, TP53, CTNNB1
phosphorylation (GO:0016310) 2.633MET, PIK3CA, CDKN3
cell differentiation (GO:0030154) 2.143CASP8, TP53, CTNNB1
cellular biosynthetic process (GO:0044249) 1.373TP53, PIK3CA, CTNNB1
anatomical structure morphogenesis (GO:0009653) 2.533MET, AXIN1, CTNNB1
protein complex disassembly (GO:0043241) 4.583APC, AXIN1, CTNNB1
negative regulation of catalytic activity (GO:0043086) 3.03APC, CASP8, TP53
response to organic cyclic compound (GO:0014070) 3.073AXIN1, CASP8, CTNNB1
negative regulation of protein metabolic process (GO:0051248) 2.823APC, CASP8, CTNNB1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.123AXIN1, TP53, CTNNB1
positive regulation of multicellular organismal process (GO:0051240) 2.493MET, CASP8, CTNNB1
regulation of cell cycle process (GO:0010564) 3.53APC, TP53, CTNNB1
biological adhesion (GO:0022610) 2.813APC, CASP8, CTNNB1
cellular response to external stimulus (GO:0071496) 4.23CASP8, TP53, CTNNB1
cell proliferation (GO:0008283) 3.233MET, TP53, CTNNB1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713AXIN1, TP53, CTNNB1
negative regulation of transcription, DNA-templated (GO:0045892) 2.753AXIN1, TP53, CTNNB1
protein oligomerization (GO:0051259) 3.713CASP8, TP53, CTNNB1
negative regulation of cellular protein metabolic process (GO:0032269) 2.883APC, CASP8, CTNNB1
cellular response to organic cyclic compound (GO:0071407) 3.933AXIN1, CASP8, CTNNB1
negative regulation of RNA metabolic process (GO:0051253) 2.663AXIN1, TP53, CTNNB1
response to drug (GO:0042493) 3.713APC, TP53, CTNNB1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813MET, TP53, CTNNB1
liver development (GO:0001889) 4.983IGF2R, PIK3CA, CTNNB1
gland development (GO:0048732) 4.153IGF2R, PIK3CA, CTNNB1
negative regulation of cellular biosynthetic process (GO:0031327) 2.493AXIN1, TP53, CTNNB1
mitotic cell cycle process (GO:1903047) 3.123APC, TP53, CDKN3
cell cycle process (GO:0022402) 2.753APC, TP53, CDKN3
cell death (GO:0008219) 3.053AXIN1, CASP8, TP53
multicellular organism development (GO:0007275) 2.543AXIN1, TP53, CTNNB1
pattern specification process (GO:0007389) 3.793APC, AXIN1, CTNNB1
macromolecular complex disassembly (GO:0032984) 4.533APC, AXIN1, CTNNB1
response to lipid (GO:0033993) 3.113IGF2R, CASP8, CTNNB1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63AXIN1, TP53, CTNNB1
negative regulation of mitotic cell cycle (GO:0045930) 4.453APC, TP53, CTNNB1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553AXIN1, TP53, CTNNB1
apoptotic process (GO:0006915) 3.143AXIN1, CASP8, TP53
negative regulation of RNA biosynthetic process (GO:1902679) 2.73AXIN1, TP53, CTNNB1
reproductive process (GO:0022414) 2.553IGF2R, CASP8, CTNNB1
biosynthetic process (GO:0009058) 1.323TP53, PIK3CA, CTNNB1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473AXIN1, TP53, CTNNB1
cell adhesion (GO:0007155) 2.823APC, CASP8, CTNNB1
response to abiotic stimulus (GO:0009628) 2.83CASP8, TP53, CTNNB1
regulation of cellular component biogenesis (GO:0044087) 3.083APC, TP53, CTNNB1
phosphate-containing compound metabolic process (GO:0006796) 2.163MET, PIK3CA, CDKN3
phosphorus metabolic process (GO:0006793) 2.153MET, PIK3CA, CDKN3
positive regulation of cellular component biogenesis (GO:0044089) 3.713APC, TP53, CTNNB1
negative regulation of apoptotic signaling pathway (GO:2001234) 4.422CASP8, CTNNB1
regulation of intracellular protein transport (GO:0033157) 3.82AXIN1, TP53
protein localization (GO:0008104) 2.362TP53, CTNNB1
positive regulation of apoptotic signaling pathway (GO:2001235) 4.582CASP8, TP53
regulation of intracellular transport (GO:0032386) 3.582AXIN1, TP53
cell development (GO:0048468) 3.282AXIN1, CTNNB1
activation of protein kinase activity (GO:0032147) 4.082AXIN1, PIK3CA
membrane organization (GO:0061024) 3.042CASP8, TP53
regulation of Wnt signaling pathway (GO:0030111) 3.982APC, AXIN1
positive regulation of neuron apoptotic process (GO:0043525) 5.882TP53, CTNNB1
regulation of histone modification (GO:0031056) 4.852TP53, CTNNB1
positive regulation of histone modification (GO:0031058) 5.322TP53, CTNNB1
cellular component morphogenesis (GO:0032989) 3.52MET, CTNNB1
organic cyclic compound biosynthetic process (GO:1901362) 1.662TP53, CTNNB1
mitochondrial membrane organization (GO:0007006) 5.22CASP8, TP53
organic cyclic compound metabolic process (GO:1901360) 1.262TP53, CTNNB1
negative regulation of hydrolase activity (GO:0051346) 3.742CASP8, TP53
cellular macromolecule localization (GO:0070727) 3.12TP53, CTNNB1
regulation of cytoskeleton organization (GO:0051493) 3.722APC, CTNNB1
response to growth factor (GO:0070848) 4.142APC, CTNNB1
peptidyl-amino acid modification (GO:0018193) 2.982MET, TP53
interspecies interaction between organisms (GO:0044419) 3.082CASP8, TP53
macromolecule localization (GO:0033036) 2.342TP53, CTNNB1
regulation of cell adhesion (GO:0030155) 3.272PIK3CA, CTNNB1
(GO:1905269) 5.252TP53, CTNNB1
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 4.542CASP8, CTNNB1
immune response-activating signal transduction (GO:0002757) 3.82CASP8, PIK3CA
positive regulation of protein kinase activity (GO:0045860) 3.612AXIN1, PIK3CA
protein heterooligomerization (GO:0051291) 5.222CASP8, CTNNB1
developmental process involved in reproduction (GO:0003006) 3.362CASP8, CTNNB1
lymphocyte activation (GO:0046649) 3.962CASP8, CTNNB1
regulation of proteolysis (GO:0030162) 3.22AXIN1, CASP8
regionalization (GO:0003002) 4.242AXIN1, CTNNB1
response to metal ion (GO:0010038) 3.912CASP8, CTNNB1
response to inorganic substance (GO:0010035) 3.562CASP8, CTNNB1
regulation of hemopoiesis (GO:1903706) 4.02CASP8, CTNNB1
heterocycle metabolic process (GO:0046483) 1.312TP53, CTNNB1
response to biotic stimulus (GO:0009607) 3.092CASP8, TP53
aromatic compound biosynthetic process (GO:0019438) 1.72TP53, CTNNB1
cellular nitrogen compound metabolic process (GO:0034641) 1.222TP53, CTNNB1
cellular response to stress (GO:0033554) 2.512APC, TP53
response to antibiotic (GO:0046677) 5.862CASP8, TP53
regulation of cyclin-dependent protein kinase activity (GO:1904029) 5.212APC, CDKN3
regulation of canonical Wnt signaling pathway (GO:0060828) 4.262APC, AXIN1
regulation of mitotic cell cycle phase transition (GO:1901990) 4.232APC, TP53
positive regulation of catabolic process (GO:0009896) 3.942APC, AXIN1
embryonic morphogenesis (GO:0048598) 3.722AXIN1, CTNNB1
regulation of catabolic process (GO:0009894) 3.522APC, AXIN1
embryonic organ morphogenesis (GO:0048562) 4.922AXIN1, CTNNB1
cellular component disassembly involved in execution phase of apoptosis (GO:0006921) 6.472APC, CASP8
positive regulation of kinase activity (GO:0033674) 3.542AXIN1, PIK3CA
cellular response to mechanical stimulus (GO:0071260) 5.332CASP8, CTNNB1
positive regulation of cell migration (GO:0030335) 3.772MET, APC
leukocyte activation (GO:0045321) 3.762CASP8, CTNNB1
morphogenesis of a branching structure (GO:0001763) 4.712MET, CTNNB1
regulation of membrane permeability (GO:0090559) 5.482CASP8, TP53
axis specification (GO:0009798) 5.422AXIN1, CTNNB1
regulation of protein transport (GO:0051223) 3.122AXIN1, TP53
negative regulation of Wnt signaling pathway (GO:0030178) 4.442APC, AXIN1
nucleic acid-templated transcription (GO:0097659) 1.912TP53, CTNNB1
response to cytokine (GO:0034097) 3.842CASP8, CTNNB1
regulation of myeloid leukocyte differentiation (GO:0002761) 5.022CASP8, CTNNB1
cell morphogenesis involved in differentiation (GO:0000904) 4.672MET, CTNNB1
cell morphogenesis (GO:0000902) 4.352MET, CTNNB1
positive regulation of hydrolase activity (GO:0051345) 2.912AXIN1, CASP8
negative regulation of transferase activity (GO:0051348) 3.872APC, TP53
positive regulation of immune system process (GO:0002684) 2.962CASP8, PIK3CA
cell cycle (GO:0007049) 3.142TP53, CDKN3
lymphocyte aggregation (GO:0071593) 4.442CASP8, CTNNB1
G-protein coupled receptor signaling pathway (GO:0007186) 2.642PDGFRL, IGF2R
regulation of telomerase activity (GO:0051972) 5.972TP53, CTNNB1
heterocycle biosynthetic process (GO:0018130) 1.72TP53, CTNNB1
skeletal system morphogenesis (GO:0048705) 4.982AXIN1, CTNNB1
embryonic skeletal system morphogenesis (GO:0048704) 5.312AXIN1, CTNNB1
organ morphogenesis (GO:0009887) 3.552AXIN1, CTNNB1
single organism cell adhesion (GO:0098602) 3.632CASP8, CTNNB1
embryonic skeletal joint morphogenesis (GO:0060272) 7.242AXIN1, CTNNB1
cell-cell adhesion (GO:0098609) 3.342CASP8, CTNNB1
beta-catenin destruction complex assembly (GO:1904885) 8.122APC, AXIN1
regulation of DNA biosynthetic process (GO:2000278) 5.172TP53, CTNNB1
tissue development (GO:0009888) 3.272PIK3CA, CTNNB1
positive regulation of MAPK cascade (GO:0043410) 3.572AXIN1, CTNNB1
regulation of cell cycle phase transition (GO:1901987) 4.152APC, TP53
single-organism membrane organization (GO:0044802) 3.192CASP8, TP53
system development (GO:0048731) 2.922PIK3CA, CTNNB1
positive regulation of neuron death (GO:1901216) 5.522TP53, CTNNB1
regulation of protein complex assembly (GO:0043254) 3.832TP53, CTNNB1
negative regulation of neuron death (GO:1901215) 4.572PIK3CA, CTNNB1
leukocyte differentiation (GO:0002521) 4.132CASP8, CTNNB1
RNA metabolic process (GO:0016070) 1.592TP53, CTNNB1
regulation of microtubule cytoskeleton organization (GO:0070507) 4.982APC, CTNNB1
endocytosis (GO:0006897) 3.692IGF2R, PIK3CA
dorsal/ventral axis specification (GO:0009950) 7.022AXIN1, CTNNB1
negative regulation of protein modification process (GO:0031400) 3.42APC, CTNNB1
regulation of cellular response to stress (GO:0080135) 3.42MET, AXIN1
ectodermal placode formation (GO:0060788) 7.022AXIN1, CTNNB1
positive regulation of protein catabolic process (GO:0045732) 4.182APC, AXIN1
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:1900740) 6.332CASP8, TP53
regulation of cell motility (GO:2000145) 3.162APC, MET
transcription, DNA-templated (GO:0006351) 1.912TP53, CTNNB1
positive regulation of cell motility (GO:2000147) 3.742MET, APC
leukocyte cell-cell adhesion (GO:0007159) 4.262CASP8, CTNNB1
positive regulation of chromosome organization (GO:2001252) 4.762TP53, CTNNB1
regulation of myeloid cell differentiation (GO:0045637) 4.562CASP8, CTNNB1
regulation of sister chromatid segregation (GO:0033045) 5.632APC, CTNNB1
RNA biosynthetic process (GO:0032774) 1.842TP53, CTNNB1
regulation of T cell activation (GO:0050863) 4.052PIK3CA, CTNNB1
regulation of fibroblast proliferation (GO:0048145) 5.322TP53, CTNNB1
pancreas development (GO:0031016) 6.472APC, CTNNB1
negative regulation of cellular component organization (GO:0051129) 3.352APC, CTNNB1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722TP53, CTNNB1
regulation of protein catabolic process (GO:0042176) 3.832APC, AXIN1
negative regulation of mitotic cell cycle phase transition (GO:1901991) 4.822APC, TP53
response to mechanical stimulus (GO:0009612) 4.412CASP8, CTNNB1
cellular macromolecule biosynthetic process (GO:0034645) 1.662TP53, CTNNB1
regulation of microtubule-based process (GO:0032886) 4.792APC, CTNNB1
positive regulation of establishment of protein localization (GO:1904951) 3.492CASP8, TP53
positive regulation of cellular protein localization (GO:1903829) 3.852CASP8, TP53
regulation of MAPK cascade (GO:0043408) 3.222AXIN1, CTNNB1
response to endogenous stimulus (GO:0009719) 2.792APC, CTNNB1
nucleobase-containing compound metabolic process (GO:0006139) 1.352TP53, CTNNB1
regulation of lymphocyte activation (GO:0051249) 3.732PIK3CA, CTNNB1
formation of primary germ layer (GO:0001704) 5.762AXIN1, CTNNB1
cell fate specification (GO:0001708) 5.572APC, CTNNB1
vasculature development (GO:0001944) 6.042PIK3CA, CTNNB1
regulation of protein modification by small protein conjugation or removal (GO:1903320) 4.142AXIN1, CTNNB1
negative regulation of cell cycle phase transition (GO:1901988) 4.742APC, TP53
cellular localization (GO:0051641) 2.322TP53, CTNNB1
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.012PIK3CA, CTNNB1
cellular response to endogenous stimulus (GO:0071495) 3.332APC, CTNNB1
tube morphogenesis (GO:0035239) 4.352MET, CTNNB1
positive regulation of cellular component movement (GO:0051272) 3.712APC, MET
cellular aromatic compound metabolic process (GO:0006725) 1.32TP53, CTNNB1
cellular response to DNA damage stimulus (GO:0006974) 3.172APC, TP53
regulation of establishment of protein localization to mitochondrion (GO:1903747) 4.882CASP8, TP53
regulation of cellular component movement (GO:0051270) 3.082APC, MET
branching morphogenesis of an epithelial tube (GO:0048754) 4.932MET, CTNNB1
cell-cell junction organization (GO:0045216) 4.662APC, CTNNB1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592TP53, CTNNB1
cell junction assembly (GO:0034329) 4.862APC, CTNNB1
regulation of chromosome segregation (GO:0051983) 5.382APC, CTNNB1
positive regulation of establishment of protein localization to mitochondrion (GO:1903749) 4.982CASP8, TP53
nucleic acid metabolic process (GO:0090304) 1.462TP53, CTNNB1
regulation of immune response (GO:0050776) 2.982CASP8, PIK3CA
cellular response to growth factor stimulus (GO:0071363) 4.272APC, CTNNB1
cell cycle checkpoint (GO:0000075) 4.792APC, TP53
positive regulation of developmental process (GO:0051094) 2.772CASP8, CTNNB1
positive regulation of cell differentiation (GO:0045597) 3.012CASP8, CTNNB1
positive regulation of immune response (GO:0050778) 3.42CASP8, PIK3CA
macromolecule biosynthetic process (GO:0009059) 1.612TP53, CTNNB1
nitrogen compound metabolic process (GO:0006807) 1.132TP53, CTNNB1
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.272CASP8, CTNNB1
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901030) 6.122CASP8, TP53
myeloid cell differentiation (GO:0030099) 4.632CASP8, CTNNB1
positive regulation of proteolysis (GO:0045862) 3.862AXIN1, CASP8
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:1900739) 6.332CASP8, TP53
regulation of chromatin organization (GO:1902275) 4.692TP53, CTNNB1
single organismal cell-cell adhesion (GO:0016337) 3.692CASP8, CTNNB1
regulation of cell activation (GO:0050865) 3.532PIK3CA, CTNNB1
regulation of peptidyl-serine phosphorylation (GO:0033135) 4.982AXIN1, PIK3CA
cell junction organization (GO:0034330) 4.512APC, CTNNB1
apoptotic signaling pathway (GO:0097190) 4.122CASP8, TP53
T cell activation (GO:0042110) 4.452CASP8, CTNNB1
homeostatic process (GO:0042592) 2.612PIK3CA, CTNNB1
regulation of cell-cell adhesion (GO:0022407) 3.792PIK3CA, CTNNB1
negative regulation of cell cycle process (GO:0010948) 4.372APC, TP53
regulation of mitochondrion organization (GO:0010821) 4.342CASP8, TP53
positive regulation of mitochondrion organization (GO:0010822) 4.612CASP8, TP53
morphogenesis of an epithelium (GO:0002009) 4.082MET, CTNNB1
response to estradiol (GO:0032355) 4.732CASP8, CTNNB1
intracellular receptor signaling pathway (GO:0030522) 4.62CASP8, CTNNB1
regulation of leukocyte activation (GO:0002694) 3.62PIK3CA, CTNNB1
chromatin organization (GO:0006325) 3.282TP53, CTNNB1
regulation of growth (GO:0040008) 3.262TP53, PIK3CA
positive regulation of transport (GO:0051050) 2.92CASP8, TP53
myeloid leukocyte differentiation (GO:0002573) 5.232CASP8, CTNNB1
tissue morphogenesis (GO:0048729) 3.872MET, CTNNB1
regulation of nucleocytoplasmic transport (GO:0046822) 4.332AXIN1, TP53
multi-organism process (GO:0051704) 2.652CASP8, TP53
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028) 5.942CASP8, TP53
negative regulation of canonical Wnt signaling pathway (GO:0090090) 4.632APC, AXIN1
protein phosphorylation (GO:0006468) 2.892MET, PIK3CA
regulation of cell migration (GO:0030334) 3.232APC, MET
viral process (GO:0016032) 3.152CASP8, TP53
morphogenesis of a branching epithelium (GO:0061138) 4.772MET, CTNNB1
positive regulation of protein complex assembly (GO:0031334) 4.442TP53, CTNNB1
cellular protein localization (GO:0034613) 3.112TP53, CTNNB1
single-organism transport (GO:0044765) 2.182PIK3CA, CTNNB1
multi-organism cellular process (GO:0044764) 3.142CASP8, TP53
T cell aggregation (GO:0070489) 4.452CASP8, CTNNB1
cell communication (GO:0007154) 3.042TP53, CTNNB1
positive regulation of peptidyl-serine phosphorylation (GO:0033138) 5.262AXIN1, PIK3CA
leukocyte aggregation (GO:0070486) 4.412CASP8, CTNNB1
single-organism localization (GO:1902578) 2.092PIK3CA, CTNNB1
immune response-regulating signaling pathway (GO:0002764) 3.722CASP8, PIK3CA
cellular response to oxygen-containing compound (GO:1901701) 3.222PIK3CA, CTNNB1
regulation of locomotion (GO:0040012) 3.122MET, APC
positive regulation of locomotion (GO:0040017) 3.712APC, MET
negative regulation of cell differentiation (GO:0045596) 3.332AXIN1, CTNNB1
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) 5.262APC, CDKN3
regulation of mitochondrial membrane permeability (GO:0046902) 5.552CASP8, TP53
regulation of leukocyte differentiation (GO:1902105) 4.262CASP8, CTNNB1
regulation of multicellular organismal development (GO:2000026) 2.312CASP8, CTNNB1
activation of immune response (GO:0002253) 3.672CASP8, PIK3CA
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152CASP8, TP53
mitotic cell cycle checkpoint (GO:0007093) 5.312APC, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of intracellular protein transport (GO:0033157) -3.80.008CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of kinase activity (GO:0043549) -3.070.049APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of phosphate metabolic process (GO:0019220) -2.350.031APC, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of apoptotic signaling pathway (GO:2001233) -3.830.003CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of intracellular transport (GO:0032386) -3.580.009CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
activation of protein kinase activity (GO:0032147) -4.080.006CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
male gonad development (GO:0008584) NEW5.080.036TP53, CASP8, PIK3CA, CTNNB1
regulation of Wnt signaling pathway (GO:0030111) -3.980.0APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
T cell activation (GO:0042110) -4.450.005APC, CASP8, TP53, CTNNB1
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.001APC, CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) -3.540.0APC, CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
negative regulation of cell cycle (GO:0045786) -3.670.0APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of organelle organization (GO:0033043) -2.720.002APC, CASP8, MET, IGF2R, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
organ development (GO:0048513) -2.530.025APC, CASP8, MET, IGF2R, TP53, CTNNB1
morphogenesis of a branching epithelium (GO:0061138) -4.770.021APC, MET, AXIN1, TP53, CTNNB1
regulation of protein sumoylation (GO:0033233) NEW6.680.003AXIN1, TP53, CTNNB1
regulation of thymocyte apoptotic process (GO:0070243) NEW7.240.042CASP8, TP53
negative regulation of response to stimulus (GO:0048585) -2.520.017APC, CASP8, MET, TP53, AXIN1, CTNNB1
neurotrophin signaling pathway (GO:0038179) NEW6.550.005APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
regulation of DNA metabolic process (GO:0051052) -3.870.009APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
T cell differentiation (GO:0030217) NEW5.110.029APC, TP53, CTNNB1
negative regulation of cell death (GO:0060548) -2.950.048MET, CASP8, TP53, CTNNB1, PIK3CA
regulation of protein kinase activity (GO:0045859) -3.150.016APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
protein heterooligomerization (GO:0051291) -5.220.012MET, AXIN1, CASP8, CTNNB1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) NEW3.830.038CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of proteolysis (GO:0030162) -3.20.03APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regionalization (GO:0003002) -4.240.012APC, AXIN1, TP53, CTNNB1
response to peptide hormone (GO:0043434) NEW4.060.003APC, CASP8, MET, PIK3CA, MTUS1, TP53, CTNNB1
regulation of phosphorylation (GO:0042325) -2.50.001APC, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
negative regulation of phosphorylation (GO:0042326) NEW3.70.002APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of MAP kinase activity (GO:0043405) NEW3.950.011CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028) -5.940.023IGF2R, CASP8, TP53
response to hormone (GO:0009725) NEW3.330.032APC, CASP8, MET, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
regulation of microtubule cytoskeleton organization (GO:0070507) -4.980.027APC, AXIN1, TP53, CTNNB1
regulation of canonical Wnt signaling pathway (GO:0060828) -4.260.0APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of catabolic process (GO:0009896) -3.940.005APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
cell surface receptor signaling pathway (GO:0007166) -2.090.005APC, CASP8, MET, PDGFRL, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
cellular component disassembly involved in execution phase of apoptosis (GO:0006921) -6.470.004APC, CASP8, CTNNB1
positive regulation of kinase activity (GO:0033674) -3.540.027APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
cellular response to mechanical stimulus (GO:0071260) -5.330.007TP53, CASP8, PIK3CA, CTNNB1
regulation of DNA binding (GO:0051101) NEW5.210.012APC, AXIN1, TP53, CTNNB1
positive regulation of cell migration (GO:0030335) -3.770.021APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
platelet-derived growth factor receptor signaling pathway (GO:0048008) NEW6.150.013MET, PDGFRL, TP53
morphogenesis of a branching structure (GO:0001763) -4.710.035MET, APC, AXIN1, TP53, CTNNB1
regulation of mononuclear cell proliferation (GO:0032944) NEW4.450.032MET, AXIN1, TP53, CTNNB1, PIK3CA
regulation of catenin import into nucleus (GO:0035412) NEW6.470.0TP53, AXIN1, PIK3CA, CTNNB1
regulation of JNK cascade (GO:0046328) NEW4.650.012MET, AXIN1, TP53, CTNNB1, PIK3CA
regulation of protein serine/threonine kinase activity (GO:0071900) -3.580.0APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
negative regulation of Wnt signaling pathway (GO:0030178) -4.440.005APC, MET, AXIN1, TP53, CTNNB1
regulation of myeloid leukocyte differentiation (GO:0002761) -5.020.029APC, CASP8, CTNNB1
regulation of mitotic cell cycle (GO:0007346) -3.710.003APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of GTPase activity (GO:0043547) NEW3.280.009APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of immune system process (GO:0002684) -2.960.012APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of MAPK cascade (GO:0043408) -3.220.032APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.042CASP8, TP53, AXIN1, PIK3CA, CTNNB1
ectodermal placode formation (GO:0060788) -7.020.048AXIN1, CTNNB1
positive regulation of cellular component organization (GO:0051130) -2.680.043APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of establishment of protein localization (GO:0070201) -3.020.04CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
embryonic skeletal joint morphogenesis (GO:0060272) -7.240.036AXIN1, CTNNB1
T cell differentiation in thymus (GO:0033077) NEW6.330.037APC, TP53, CTNNB1
regulation of behavior (GO:0050795) NEW5.550.047MTUS1, MET, AXIN1, TP53, PIK3CA
positive regulation of intracellular signal transduction (GO:1902533) -2.950.036MET, AXIN1, CASP8, TP53, CTNNB1
cell cycle arrest (GO:0007050) -4.690.004APC, TP53, AXIN1, CTNNB1, CDKN3
regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768) NEW7.530.018APC, CTNNB1
cell activation (GO:0001775) -3.470.015APC, TP53, CASP8, PIK3CA, CTNNB1
positive regulation of proteolysis (GO:0045862) -3.860.015AXIN1, CASP8, TP53, PIK3CA
negative regulation of intracellular signal transduction (GO:1902532) NEW3.630.003APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of protein import into nucleus (GO:0042306) NEW4.540.014MET, AXIN1, TP53, CTNNB1, PIK3CA
regulation of protein complex assembly (GO:0043254) -3.830.007APC, CASP8, MET, TP53, AXIN1, CTNNB1
regulation of intracellular signal transduction (GO:1902531) -2.310.042APC, CASP8, MET, TP53, AXIN1, CTNNB1
negative regulation of cell cycle phase transition (GO:1901988) -4.740.009MET, APC, TP53, CTNNB1, PIK3CA
regulation of protein localization to nucleus (GO:1900180) NEW4.340.025MET, AXIN1, TP53, CTNNB1, PIK3CA
regulation of protein processing (GO:0070613) NEW5.350.001APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
mitotic cell cycle process (GO:1903047) -3.120.03APC, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
dorsal/ventral axis specification (GO:0009950) -7.020.036AXIN1, CTNNB1
negative regulation of protein modification process (GO:0031400) -3.40.006APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of cellular response to stress (GO:0080135) -3.40.006APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of transferase activity (GO:0051338) -2.880.05APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of leukocyte activation (GO:0002694) -3.60.007CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of cell motility (GO:2000145) -3.160.004APC, CASP8, MET, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
regulation of nucleocytoplasmic transport (GO:0046822) -4.330.048MET, TP53, AXIN1, PIK3CA, CTNNB1
positive regulation of cell motility (GO:2000147) -3.740.024APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of protein maturation (GO:1903317) NEW5.330.001APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
olfactory placode formation (GO:0030910) NEW8.340.015AXIN1, CTNNB1
regulation of response to external stimulus (GO:0032101) NEW3.060.008APC, MET, IGF2R, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
mammary placode formation (GO:0060596) NEW8.630.015AXIN1, CTNNB1
positive regulation of MAP kinase activity (GO:0043406) NEW4.390.044MET, AXIN1, TP53, CTNNB1, PIK3CA
regulation of protein catabolic process (GO:0042176) -3.830.004APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
negative regulation of mitotic cell cycle phase transition (GO:1901991) -4.820.007MET, APC, TP53, PIK3CA, CTNNB1
regulation of mitotic cell cycle phase transition (GO:1901990) -4.230.002APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
glomerular epithelial cell development (GO:0072310) NEW7.430.0AXIN1, TP53, CTNNB1
axis specification (GO:0009798) -5.420.021APC, AXIN1, TP53, CTNNB1
epidermis development (GO:0008544) NEW5.040.0APC, CASP8, MET, TP53, AXIN1, CTNNB1
regulation of GTPase activity (GO:0043087) NEW3.210.015APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of ossification (GO:0030278) NEW4.530.036APC, MET, AXIN1, TP53, CTNNB1
negative regulation of MAPK cascade (GO:0043409) NEW4.740.004APC, MET, CASP8, TP53, PIK3CA
regulation of protein localization (GO:0032880) -2.880.01APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
activation of JUN kinase activity (GO:0007257) NEW6.170.0MET, AXIN1, TP53, CTNNB1
negative regulation of heart induction (GO:1901320) NEW9.730.006AXIN1, CTNNB1
regulation of lymphocyte activation (GO:0051249) -3.730.003CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
negative regulation of phosphorus metabolic process (GO:0010563) NEW3.450.005APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of protein metabolic process (GO:0051246) -1.930.003APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
positive regulation of protein metabolic process (GO:0051247) -2.430.001APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of nucleotide catabolic process (GO:0030811) NEW8.340.033APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of protein modification by small protein conjugation or removal (GO:1903320) -4.140.015MET, TP53, AXIN1, PIK3CA, CTNNB1
leukocyte differentiation (GO:0002521) -4.130.013APC, CASP8, TP53, CTNNB1
regulation of protein modification process (GO:0031399) -2.320.002APC, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of cell cycle phase transition (GO:1901987) -4.150.002APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
negative regulation of cell proliferation (GO:0008285) -3.260.011APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
reproductive structure development (GO:0048608) NEW4.080.022CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of stress-activated protein kinase signaling cascade (GO:0070302) NEW4.440.001CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
epithelium development (GO:0060429) NEW4.570.018APC, CASP8, MET, TP53, AXIN1, CTNNB1
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304) NEW4.820.017AXIN1, CASP8, TP53, PIK3CA
regulation of vesicle-mediated transport (GO:0060627) NEW3.630.002APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of stress-activated MAPK cascade (GO:0032872) NEW4.450.021MET, AXIN1, TP53, CTNNB1, PIK3CA
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124) NEW5.780.046CASP8, TP53, CTNNB1
regulation of cellular component movement (GO:0051270) -3.080.007APC, CASP8, MET, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
response to acid chemical (GO:0001101) NEW4.050.033MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
response to cold (GO:0009409) NEW5.90.048CASP8, TP53, CTNNB1
regulation of localization (GO:0032879) -1.940.033APC, CASP8, MET, TP53, MTUS1, AXIN1, CTNNB1
negative regulation of developmental process (GO:0051093) NEW3.170.03APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
negative regulation of cellular protein metabolic process (GO:0032269) -2.880.035APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of cellular protein metabolic process (GO:0032268) -1.990.0APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
negative regulation of cardiac cell fate specification (GO:2000044) NEW9.730.006AXIN1, CTNNB1
cellular response to organic cyclic compound (GO:0071407) -3.930.028CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of lymphocyte proliferation (GO:0050670) NEW4.460.032MET, AXIN1, TP53, CTNNB1, PIK3CA
cell cycle process (GO:0022402) -2.750.035APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
gland development (GO:0048732) -4.150.007MET, APC, IGF2R, CTNNB1
positive regulation of protein kinase activity (GO:0045860) -3.610.02APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
activation of MAPK activity (GO:0000187) NEW4.790.005MET, TP53, AXIN1, PIK3CA, CTNNB1
regulation of protein stability (GO:0031647) NEW4.330.004MET, AXIN1, CASP8, TP53, CTNNB1
regulation of cell activation (GO:0050865) -3.530.013CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of peptidyl-serine phosphorylation (GO:0033135) -4.980.047MET, AXIN1, PIK3CA, CTNNB1
branching morphogenesis of an epithelial tube (GO:0048754) -4.930.011APC, MET, AXIN1, TP53, CTNNB1
intrinsic apoptotic signaling pathway (GO:0097193) NEW4.690.003TP53, CASP8, IGF2R, PIK3CA, CTNNB1
regulation of JUN kinase activity (GO:0043506) NEW5.330.02MET, AXIN1, PIK3CA, CTNNB1
epithelial tube formation (GO:0072175) NEW6.360.012CASP8, TP53, CTNNB1
liver development (GO:0001889) -4.980.019MET, IGF2R, TP53, CTNNB1
positive regulation of protein serine/threonine kinase activity (GO:0071902) NEW4.060.01CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of cell death (GO:0010942) -3.320.014APC, CASP8, MET, IGF2R, PIK3CA, TP53, CTNNB1
canonical Wnt signaling pathway (GO:0060070) -5.260.019APC, AXIN1, TP53, CTNNB1
regulation of cell death (GO:0010941) -2.430.004APC, CASP8, MET, IGF2R, PIK3CA, TP53, CTNNB1
programmed cell death (GO:0012501) -3.10.013APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of locomotion (GO:0040012) -3.120.008APC, CASP8, MET, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
positive regulation of apoptotic process (GO:0043065) -3.380.007APC, CASP8, MET, IGF2R, PIK3CA, TP53, CTNNB1
regulation of programmed cell death (GO:0043067) -2.490.003APC, CASP8, MET, IGF2R, PIK3CA, TP53, CTNNB1
cell differentiation involved in embryonic placenta development (GO:0060706) NEW6.590.015AXIN1, CASP8, TP53
positive regulation of protein maturation (GO:1903319) NEW6.840.027AXIN1, CASP8, TP53, PIK3CA
positive regulation of programmed cell death (GO:0043068) -3.380.008APC, CASP8, MET, IGF2R, PIK3CA, TP53, CTNNB1
negative regulation of canonical Wnt signaling pathway (GO:0090090) -4.630.001MET, APC, AXIN1, TP53, CTNNB1
regulation of purine nucleotide catabolic process (GO:0033121) NEW8.340.032APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of cell migration (GO:0030334) -3.230.003APC, CASP8, MET, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
negative regulation of smooth muscle cell proliferation (GO:0048662) NEW6.150.038AXIN1, TP53, CTNNB1
negative regulation of phosphate metabolic process (GO:0045936) NEW3.450.005APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
apoptotic process (GO:0006915) -3.140.031APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of phosphorus metabolic process (GO:0051174) -2.350.033APC, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
regulation of nucleoside metabolic process (GO:0009118) NEW5.820.034APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
positive regulation of protein processing (GO:0010954) NEW6.90.027AXIN1, CASP8, TP53, PIK3CA
canonical Wnt signaling pathway involved in negative regulation of apoptotic process (GO:0044336) NEW8.630.028APC, CTNNB1
embryonic epithelial tube formation (GO:0001838) NEW6.40.011CASP8, TP53, CTNNB1
positive regulation of cellular component movement (GO:0051272) -3.710.026APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
axial mesoderm formation (GO:0048320) NEW9.040.003AXIN1, TP53
positive regulation of locomotion (GO:0040017) -3.710.038APC, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of cell cycle (GO:0051726) -2.930.037APC, CASP8, MET, CDKN3, AXIN1, TP53, CTNNB1, PIK3CA
anatomical structure development (GO:0048856) -1.580.026APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
regulation of cellular component biogenesis (GO:0044087) -3.080.036APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
lymphocyte activation (GO:0046649) -3.960.027APC, CASP8, TP53, CTNNB1
response to peptide (GO:1901652) NEW3.940.004APC, CASP8, MET, PIK3CA, MTUS1, TP53, CTNNB1
regulation of organ morphogenesis (GO:2000027) NEW4.220.02MET, APC, AXIN1, TP53, CTNNB1
negative regulation of protein phosphorylation (GO:0001933) NEW3.790.0APC, CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
regulation of protein phosphorylation (GO:0001932) -2.570.01APC, MET, CDKN3, AXIN1, TP53, PIK3CA
mitotic cell cycle checkpoint (GO:0007093) -5.310.016MET, APC, PIK3CA, TP53
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1110APC, CASP8, MET, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1, PIK3CA
intracellular part (GO:0044424) 0.289APC, CASP8, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1, PIK3CA
cytoplasmic part (GO:0044444) 0.829APC, CASP8, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1, PIK3CA
membrane (GO:0016020) 0.689APC, CASP8, MET, IGF2R, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
cytoplasm (GO:0005737) 1.018APC, CASP8, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1
intracellular membrane-bounded organelle (GO:0043231) 0.68APC, CASP8, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1
intracellular organelle (GO:0043229) 0.518APC, CASP8, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1
membrane part (GO:0044425) 0.958APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
membrane-bounded organelle (GO:0043227) 0.478APC, CASP8, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1
organelle (GO:0043226) 0.48APC, CASP8, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1
protein complex (GO:0043234) 1.517APC, CASP8, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
macromolecular complex (GO:0032991) 1.357APC, CASP8, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
nucleus (GO:0005634) 1.077APC, IGF2R, CDKN3, MTUS1, AXIN1, TP53, CTNNB1
intracellular organelle part (GO:0044446) 0.817APC, CASP8, IGF2R, TP53, MTUS1, AXIN1, CTNNB1
plasma membrane (GO:0005886) 1.397APC, MET, IGF2R, PIK3CA, MTUS1, AXIN1, CTNNB1
organelle part (GO:0044422) 0.797APC, CASP8, IGF2R, TP53, MTUS1, AXIN1, CTNNB1
cytosol (GO:0005829) 1.686APC, CASP8, PIK3CA, AXIN1, TP53, CTNNB1
non-membrane-bounded organelle (GO:0043228) 1.766APC, CASP8, TP53, MTUS1, AXIN1, CTNNB1
plasma membrane part (GO:0044459) 1.956APC, CASP8, MET, IGF2R, AXIN1, CTNNB1
intracellular non-membrane-bounded organelle (GO:0043232) 1.766APC, CASP8, TP53, MTUS1, AXIN1, CTNNB1
membrane protein complex (GO:0098796) 2.845APC, CASP8, IGF2R, PIK3CA, CTNNB1
cytoskeletal part (GO:0044430) 2.495MTUS1, APC, AXIN1, CASP8, CTNNB1
nuclear part (GO:0044428) 1.555APC, CASP8, IGF2R, TP53, CTNNB1
cytoskeleton (GO:0005856) 2.554MTUS1, APC, CASP8, CTNNB1
microtubule organizing center (GO:0005815) 3.424MTUS1, APC, CASP8, CTNNB1
nucleoplasm (GO:0005654) 1.894APC, CASP8, TP53, CTNNB1
neuron part (GO:0097458) 2.644APC, AXIN1, CASP8, CTNNB1
perinuclear region of cytoplasm (GO:0048471) 3.354AXIN1, IGF2R, CTNNB1, CDKN3
cell projection (GO:0042995) 2.474APC, CASP8, CTNNB1, PIK3CA
plasma membrane region (GO:0098590) 2.973MET, APC, CTNNB1
supramolecular fiber (GO:0099512) 3.313MTUS1, APC, AXIN1
polymeric cytoskeletal fiber (GO:0099513) 3.313APC, MTUS1, AXIN1
microtubule (GO:0005874) 3.813APC, MTUS1, AXIN1
intrinsic component of membrane (GO:0031224) 1.133MET, IGF2R, TP53
organelle membrane (GO:0031090) 1.973APC, IGF2R, CASP8
integral component of membrane (GO:0016021) 1.143MET, IGF2R, TP53
mitochondrion (GO:0005739) 2.423MTUS1, CASP8, TP53
membrane-bounded vesicle (GO:0031988) 1.713AXIN1, IGF2R, CTNNB1
beta-catenin destruction complex (GO:0030877) 7.093APC, AXIN1, CTNNB1
cell junction (GO:0030054) 2.753APC, IGF2R, CTNNB1
neuron projection (GO:0043005) 3.123APC, CASP8, CTNNB1
anchoring junction (GO:0070161) 3.613APC, IGF2R, CTNNB1
lateral plasma membrane (GO:0016328) 5.893APC, AXIN1, CTNNB1
lamellipodium (GO:0030027) 4.733APC, PIK3CA, CTNNB1
cytoplasmic region (GO:0099568) 4.513APC, AXIN1, CTNNB1
adherens junction (GO:0005912) 3.663APC, IGF2R, CTNNB1
vesicle (GO:0031982) 1.643AXIN1, IGF2R, CTNNB1
plasma membrane protein complex (GO:0098797) 3.553APC, CASP8, CTNNB1
chromosomal part (GO:0044427) 3.183APC, TP53, CTNNB1
extracellular region part (GO:0044421) 1.573MTUS1, IGF2R, CTNNB1
cell cortex (GO:0005938) 4.783APC, AXIN1, CTNNB1
integral component of plasma membrane (GO:0005887) 2.572MET, IGF2R
membrane-enclosed lumen (GO:0031974) 3.052IGF2R, TP53
RNA polymerase II transcription factor complex (GO:0090575) 5.182TP53, CTNNB1
cell periphery (GO:0071944) 5.782AXIN1, CTNNB1
chromatin (GO:0000785) 3.992TP53, CTNNB1
synapse (GO:0045202) 3.582APC, CTNNB1
cell-substrate adherens junction (GO:0005924) 3.832IGF2R, CTNNB1
focal adhesion (GO:0005925) 3.832IGF2R, CTNNB1
intrinsic component of plasma membrane (GO:0031226) 2.532MET, IGF2R
bicellular tight junction (GO:0005923) 5.092APC, CTNNB1
cell-substrate junction (GO:0030055) 3.822IGF2R, CTNNB1
extracellular space (GO:0005615) 2.632MTUS1, IGF2R
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122AXIN1, IGF2R
cytoplasmic vesicle (GO:0031410) 2.872AXIN1, IGF2R
whole membrane (GO:0098805) 2.852IGF2R, CASP8
nuclear chromosome part (GO:0044454) 3.672TP53, CTNNB1
nuclear transcription factor complex (GO:0044798) 4.952TP53, CTNNB1
occluding junction (GO:0070160) 5.072APC, CTNNB1
catenin complex (GO:0016342) 7.612APC, CTNNB1
catalytic complex (GO:1902494) 2.92CASP8, PIK3CA
cell body (GO:0044297) 3.742APC, CASP8
bounding membrane of organelle (GO:0098588) 2.392IGF2R, CASP8
cell projection membrane (GO:0031253) 4.112APC, CTNNB1
cytoplasmic microtubule (GO:0005881) 5.742APC, AXIN1
nuclear chromatin (GO:0000790) 4.422TP53, CTNNB1
cell-cell adherens junction (GO:0005913) 5.812APC, CTNNB1
intracellular vesicle (GO:0097708) 2.862AXIN1, IGF2R
cell-cell junction (GO:0005911) 3.852APC, CTNNB1
extracellular vesicle (GO:1903561) 1.892IGF2R, CTNNB1
cell surface (GO:0009986) 3.442MET, IGF2R
extracellular exosome (GO:0070062) 1.892IGF2R, CTNNB1
Wnt signalosome (GO:1990909) 7.42APC, CTNNB1
extracellular organelle (GO:0043230) 1.892IGF2R, CTNNB1
organelle lumen (GO:0043233) 3.052IGF2R, TP53
cell projection part (GO:0044463) 2.972APC, CTNNB1
intracellular organelle lumen (GO:0070013) 3.052IGF2R, TP53
extracellular region (GO:0005576) 2.182MET, PDGFRL
mitochondrial part (GO:0044429) 2.922CASP8, TP53
transcription factor complex (GO:0005667) 4.12TP53, CTNNB1
centrosome (GO:0005813) 3.752APC, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
cell periphery (GO:0071944) -5.780.014AXIN1, TP53, CTNNB1
side of membrane (GO:0098552) NEW4.220.001CASP8, MET, PIK3CA, AXIN1, TP53, CTNNB1
transport vesicle (GO:0030133) NEW4.30.0MET, APC, IGF2R, TP53, CTNNB1
microtubule organizing center (GO:0005815) -3.420.023APC, CASP8, TP53, MTUS1, AXIN1, CTNNB1
microtubule (GO:0005874) -3.810.027MTUS1, APC, AXIN1, TP53, CTNNB1
cell junction (GO:0030054) -2.750.013APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
spindle (GO:0005819) NEW4.520.011MTUS1, APC, TP53, CTNNB1
extracellular space (GO:0005615) -2.630.004APC, CASP8, MET, IGF2R, PIK3CA, MTUS1, AXIN1, TP53, CTNNB1
cytoplasmic membrane-bounded vesicle (GO:0016023) -3.120.001APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
cytoplasmic vesicle (GO:0031410) -2.870.003APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
spindle pole (GO:0000922) NEW5.080.002APC, AXIN1, TP53, CTNNB1
lamellipodium (GO:0030027) -4.730.008APC, PIK3CA, CTNNB1
Golgi apparatus part (GO:0044431) NEW3.00.002APC, CASP8, MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
beta-catenin destruction complex (GO:0030877) -7.090.0APC, AXIN1, CTNNB1
perinuclear region of cytoplasm (GO:0048471) -3.350.025APC, MET, IGF2R, CDKN3, AXIN1, TP53, CTNNB1
lateral plasma membrane (GO:0016328) -5.890.005APC, AXIN1, CTNNB1
apical plasma membrane (GO:0016324) NEW4.130.029MET, CASP8, TP53, CTNNB1, PIK3CA
cell surface (GO:0009986) -3.440.04MET, IGF2R, PIK3CA, AXIN1, TP53, CTNNB1
axonal growth cone (GO:0044295) NEW6.810.048APC, CTNNB1
basolateral plasma membrane (GO:0016323) NEW4.560.048MET, CASP8, TP53, CTNNB1
cytoplasmic microtubule (GO:0005881) -5.740.009APC, AXIN1, TP53
mitotic spindle (GO:0072686) NEW6.090.001APC, TP53, CTNNB1
microvillus membrane (GO:0031528) NEW6.760.001MET, TP53, CTNNB1
sarcoplasm (GO:0016528) NEW7.720.011CASP8, TP53
cytosolic part (GO:0044445) NEW4.340.01TP53, CASP8, PIK3CA, CTNNB1