Gene table of PIK3CA : phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PIK3CA	OMIM link	Number of associated genes	genes
114550	HEPATOCELLULAR CARCINOMA	ClinVar, OMIM, HUMSAVAR	link to OMIM	11	CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1
211980	LUNG CANCER	OMIM	link to OMIM	17	RASSF1, PARK2, IRF1, DLEC1, ERBB2, CYP2A6, PPP2R1B, MAP3K8, PIK3CA, BRAF, KRAS, SLC22A18, ERCC6, FASLG, CASP8, MXRA5, EGFR
602501	MEGALENCEPHALY-CAPILLARY MALFORMATION-POLYMICROGYRIA SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	PIK3CA
114480	BREAST CANCER	OMIM, HUMSAVAR	link to OMIM	27	RB1CC1, ESR1, NBN, PALB2, SLC22A18, BRIP1, BCPR, CASP8, FAM175A, TSG101, CHEK2, BARD1, TP53, AKT1, BRCA1, PIK3CA, PHB, PPM1D, NQO2, ATM, RAD51, BRCA2, CDH1, XRCC3, HMMR, KRAS, RAD54L
162900	NEVUS, EPIDERMAL	ClinVar, OMIM	link to OMIM	5	FGFR3, PIK3CA, KRAS, NRAS, HRAS
PS158350	COWDEN DISEASE	ClinVar, OMIM, HUMSAVAR	link to OMIM	7	AKT1, PTEN, SEC23B, SDHB, PIK3CA, KLLN, SDHD
182000	KERATOSIS, SEBORRHEIC	OMIM, HUMSAVAR	link to OMIM	2	FGFR3, PIK3CA
613659	GASTRIC CANCER	OMIM	link to OMIM	9	KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS
114500	COLORECTAL CANCER	OMIM, HUMSAVAR	link to OMIM	30	TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B
167000	OVARIAN CANCER	OMIM, HUMSAVAR	link to OMIM	9	AKT1, PARK2, CTNNB1, CDH1, BRCA1, RRAS2, PIK3CA, OPCML, SEPT9
612918	CONGENITAL LIPOMATOUS OVERGROWTH, VASCULAR MALFORMATIONS, AND EPIDERMAL NEVI	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	PIK3CA

Download the gene annotation in CSV format

Annotation of the gene PIK3CA

Associated genes in ENSEMBL

ENSG00000121879

Associated proteins - SwissProt Accession ID

P42336

Associated PDB IDs

Cytogenetic Band

3q26.32

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

FOXO3

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Platelet activation	hsa04611	5.66
Focal adhesion	hsa04510	4.92
Small cell lung cancer	hsa05222	6.17
cGMP-PKG signaling pathway	hsa04022	5.32
Natural killer cell mediated cytotoxicity	hsa04650	5.53
Colorectal cancer	hsa05210	6.52
Renal cell carcinoma	hsa05211	6.6
Jak-STAT signaling pathway	hsa04630	5.44
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
cAMP signaling pathway	hsa04024	5.05
Prostate cancer	hsa05215	6.11
Leukocyte transendothelial migration	hsa04670	5.74
Cholinergic synapse	hsa04725	5.88
Choline metabolism in cancer	hsa05231	6.09
FoxO signaling pathway	hsa04068	5.63
Osteoclast differentiation	hsa04380	5.64
HIF-1 signaling pathway	hsa04066	5.9
Chemokine signaling pathway	hsa04062	5.19
Oxytocin signaling pathway	hsa04921	5.4
Inositol phosphate metabolism	hsa00562	6.72
Aldosterone-regulated sodium reabsorption	hsa04960	7.41
Acute myeloid leukemia	hsa05221	6.74
VEGF signaling pathway	hsa04370	6.77
Endometrial cancer	hsa05213	6.81
Type II diabetes mellitus	hsa04930	7.12
Progesterone-mediated oocyte maturation	hsa04914	6.18
Chagas disease (American trypanosomiasis)	hsa05142	5.99
Pancreatic cancer	hsa05212	6.56
Amoebiasis	hsa05146	5.82
Epstein-Barr virus infection	hsa05169	4.97
Toxoplasmosis	hsa05145	5.71
Influenza A	hsa05164	5.21
Apoptosis	hsa04210	6.23
HTLV-I infection	hsa05166	4.59
PI3K-Akt signaling pathway	hsa04151	4.21
Hepatitis C	hsa05160	5.68
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
B cell receptor signaling pathway	hsa04662	6.52
Chronic myeloid leukemia	hsa05220	6.48
Bacterial invasion of epithelial cells	hsa05100	6.34
Proteoglycans in cancer	hsa05205	5.02
MicroRNAs in cancer	hsa05206	5.38
Toll-like receptor signaling pathway	hsa04620	6.0
Pathways in cancer	hsa05200	3.98
Viral carcinogenesis	hsa05203	5.08
T cell receptor signaling pathway	hsa04660	6.01
Phosphatidylinositol signaling system	hsa04070	6.38
Rap1 signaling pathway	hsa04015	4.97
Ras signaling pathway	hsa04014	4.9
Inflammatory mediator regulation of TRP channels	hsa04750	6.07
Prolactin signaling pathway	hsa04917	6.6
Fc gamma R-mediated phagocytosis	hsa04666	6.21
Estrogen signaling pathway	hsa04915	6.11
TNF signaling pathway	hsa04668	5.96
Thyroid hormone signaling pathway	hsa04919	5.82
AMPK signaling pathway	hsa04152	5.8
mTOR signaling pathway	hsa04150	6.72
Regulation of actin cytoskeleton	hsa04810	4.9
Carbohydrate digestion and absorption	hsa04973	7.28
Non-small cell lung cancer	hsa05223	6.88
Insulin signaling pathway	hsa04910	5.55
Neurotrophin signaling pathway	hsa04722	5.78
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51
Central carbon metabolism in cancer	hsa05230	6.7
Glioma	hsa05214	6.66
Fc epsilon RI signaling pathway	hsa04664	6.6
Adrenergic signaling in cardiomyocytes	hsa04261	5.44
ErbB signaling pathway	hsa04012	6.15

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.94
GPVI-mediated activation cascade	R-HSA-114604	7.18
Interleukin-2 signaling	R-HSA-451927	5.05
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
Cell-Cell communication	R-HSA-1500931	5.87
GAB1 signalosome	R-HSA-180292	6.31
Signaling by VEGF	R-HSA-194138	4.66
IRS-mediated signalling	R-HSA-112399	4.87
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08
TCR signaling	R-HSA-202403	6.64
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.07
Signaling by FGFR1 in disease	R-HSA-5655302	7.81
Signaling by EGFR	R-HSA-177929	4.59
G alpha (q) signalling events	R-HSA-416476	5.42
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
DAP12 interactions	R-HSA-2172127	4.56
Tie2 Signaling	R-HSA-210993	8.81
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by ERBB2	R-HSA-1227986	4.66
PI3K/AKT activation	R-HSA-198203	6.32
Immune System	R-HSA-168256	2.37
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Downstream signal transduction	R-HSA-186763	4.65
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
Regulation of signaling by CBL	R-HSA-912631	8.52
CD28 co-stimulation	R-HSA-389356	7.98
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59
Signaling by EGFR in Cancer	R-HSA-1643713	8.73
FGFR1 mutant receptor activation	R-HSA-1839124	8.12
Signaling by FGFR in disease	R-HSA-1226099	7.49
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Interleukin receptor SHC signaling	R-HSA-912526	5.09
Innate Immune System	R-HSA-168249	3.17
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
Signaling by FGFR2	R-HSA-5654738	4.68
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
PI3K Cascade	R-HSA-109704	6.68
Signaling by FGFR2 in disease	R-HSA-5655253	8.23
Signaling by FGFR3 in disease	R-HSA-5655332	8.52
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05
IGF1R signaling cascade	R-HSA-2428924	4.85
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
Signaling by Insulin receptor	R-HSA-74752	4.73
Disease	R-HSA-1643685	3.33
Insulin receptor signalling cascade	R-HSA-74751	4.85
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
Role of phospholipids in phagocytosis	R-HSA-2029485	5.47
Downstream TCR signaling	R-HSA-202424	7.01
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
Signaling by FGFR1 fusion mutants	R-HSA-1839117	8.81
Signaling by PDGF	R-HSA-186797	4.53
Nephrin interactions	R-HSA-373753	8.46
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85
Signaling by Interleukins	R-HSA-449147	4.71
Cell surface interactions at the vascular wall	R-HSA-202733	6.32
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Metabolism	R-HSA-1430728	2.34
Signaling by ERBB4	R-HSA-1236394	4.7
Adaptive Immune System	R-HSA-1280218	3.19
PIP3 activates AKT signaling	R-HSA-1257604	6.37
Platelet activation, signaling and aggregation	R-HSA-76002	5.15
Phospholipid metabolism	R-HSA-1483257	5.83
PI Metabolism	R-HSA-1483255	7.31
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79
Costimulation by the CD28 family	R-HSA-388841	6.56
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
Signaling by FGFR	R-HSA-190236	4.67
G alpha (12/13) signalling events	R-HSA-416482	6.75
GPCR downstream signaling	R-HSA-388396	3.07
Signaling by SCF-KIT	R-HSA-1433557	4.73
DAP12 signaling	R-HSA-2424491	4.64
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73
Signalling by NGF	R-HSA-166520	4.23
Signaling by GPCR	R-HSA-372790	2.68
G-protein beta:gamma signalling	R-HSA-397795	7.31
Signaling by FGFR4 in disease	R-HSA-5655291	9.52
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
kinase regulator activity	GO:0019207	4.5
purine ribonucleoside triphosphate binding	GO:0035639	2.22
kinase activator activity	GO:0019209	5.58
binding	GO:0005488	0.18
phosphatidylinositol 3-kinase activity	GO:0035004	5.49
1-phosphatidylinositol-4-phosphate 3-kinase activity	GO:0035005	7.79
molecular function regulator	GO:0098772	2.51
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	5.61
insulin receptor substrate binding	GO:0043560	7.25
protein serine/threonine kinase activity	GO:0004674	3.64
nucleotide binding	GO:0000166	1.96
phosphatidylinositol bisphosphate kinase activity	GO:0052813	5.56
transferase activity	GO:0016740	1.95
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
ATP binding	GO:0005524	2.43
protein kinase regulator activity	GO:0019887	4.6
1-phosphatidylinositol-3-kinase activity	GO:0016303	5.98
enzyme regulator activity	GO:0030234	2.85
kinase activity	GO:0016301	2.93
phosphatidylinositol phosphate kinase activity	GO:0016307	6.97
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
protein kinase activator activity	GO:0030295	5.68
adenyl nucleotide binding	GO:0030554	2.4
phosphatidylinositol kinase activity	GO:0052742	5.81
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
carbohydrate derivative binding	GO:0097367	2.03
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
organic cyclic compound binding	GO:0097159	1.05
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
enzyme activator activity	GO:0008047	3.56