Gene table of DPYD : dihydropyrimidine dehydrogenase

Gene-disease associations table

Disease IDDisease nameSource of annotation with DPYDOMIM linkNumber of associated genesgenes
274270DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCYClinVar, OMIM, HUMSAVAR link to OMIM 1DPYD
PS142623HIRSCHSPRUNG DISEASEClinVar link to OMIM 21TSC2, KDR, GDNF, PTCH1, GFRA1, NTF3, IRAK3, EDN3, ZHX2, THBS4, AHNAK, POLR2F, FBN1, RET, CNTN5, DPYD, EDNRB, CREBBP, SEMA3D, FAT3, PLAU

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Annotation of the gene DPYD

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Drug metabolism - other enzymeshsa009837.21
Metabolic pathwayshsa011002.49
Pantothenate and CoA biosynthesishsa007708.68
Pyrimidine metabolismhsa002406.01
beta-Alanine metabolismhsa004107.72
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Metabolism of nucleotidesR-HSA-158696.7
Pyrimidine metabolismR-HSA-738488.4
MetabolismR-HSA-14307282.34
Pyrimidine catabolismR-HSA-736219.4
Associated GO terms for Molecular function
GO termGO IDGO IC
bindingGO:00054880.18
ion bindingGO:00431671.36
heterocyclic compound bindingGO:19013631.06
nucleoside phosphate bindingGO:19012651.96
oxidoreductase activityGO:00164913.12
coenzyme bindingGO:00506624.53
NADP bindingGO:00506615.93
flavin adenine dinucleotide bindingGO:00506605.41
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptorGO:00166286.56
oxidoreductase activity, acting on the CH-CH group of donorsGO:00166275.66
nucleotide bindingGO:00001661.96
metal ion bindingGO:00468721.41
identical protein bindingGO:00428022.63
protein homodimerization activityGO:00428033.16
cation bindingGO:00431691.4
dihydropyrimidine dehydrogenase (NADP+) activityGO:00171139.74
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
cofactor bindingGO:00480374.16
metal cluster bindingGO:00515405.55
4 iron, 4 sulfur cluster bindingGO:00515396.0
organic cyclic compound bindingGO:00971591.05
iron-sulfur cluster bindingGO:00515365.55
protein bindingGO:00055150.46
protein dimerization activityGO:00469832.72