Gene table of KDR : kinase insert domain receptor

Gene-disease associations table

Disease ID	Disease name	Source of annotation with KDR	OMIM link	Number of associated genes	genes
PS142623	HIRSCHSPRUNG DISEASE	ClinVar	link to OMIM	21	TSC2, KDR, GDNF, PTCH1, GFRA1, NTF3, IRAK3, EDN3, ZHX2, THBS4, AHNAK, POLR2F, FBN1, RET, CNTN5, DPYD, EDNRB, CREBBP, SEMA3D, FAT3, PLAU
602089	HEMANGIOMA, CAPILLARY INFANTILE	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	FLT4, ANTXR1, KDR

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Annotation of the gene KDR

Associated genes in ENSEMBL

ENSG00000128052

Associated proteins - SwissProt Accession ID

P35968

Associated PDB IDs

Cytogenetic Band

4q12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
VEGF signaling pathway	hsa04370	6.77
Proteoglycans in cancer	hsa05205	5.02
Rap1 signaling pathway	hsa04015	4.97
Ras signaling pathway	hsa04014	4.9
Endocytosis	hsa04144	4.92
Focal adhesion	hsa04510	4.92
Cytokine-cytokine receptor interaction	hsa04060	4.67
PI3K-Akt signaling pathway	hsa04151	4.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Integrin cell surface interactions	R-HSA-216083	6.57
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	9.98
EPH-Ephrin signaling	R-HSA-2682334	6.43
Signaling by VEGF	R-HSA-194138	4.66
VEGF ligand-receptor interactions	R-HSA-194313	9.98
Neurophilin interactions with VEGF and VEGFR	R-HSA-194306	10.98
EPHA-mediated growth cone collapse	R-HSA-3928663	7.89
Extracellular matrix organization	R-HSA-1474244	4.91
Signal Transduction	R-HSA-162582	1.78
Axon guidance	R-HSA-422475	3.93
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07
Developmental Biology	R-HSA-1266738	3.48

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
heat shock protein binding	GO:0031072	5.24
growth factor binding	GO:0019838	4.89
molecular transducer activity	GO:0060089	2.32
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
vascular endothelial growth factor binding	GO:0038085	8.13
receptor signaling protein activity	GO:0005057	4.76
transferase activity	GO:0016740	1.95
nucleotide binding	GO:0000166	1.96
receptor signaling protein tyrosine kinase activity	GO:0004716	7.44
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
protein tyrosine kinase activity	GO:0004713	4.54
ribonucleoside binding	GO:0032549	2.22
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
Hsp90 protein binding	GO:0051879	6.37
ATP binding	GO:0005524	2.43
integrin binding	GO:0005178	5.07
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cell adhesion molecule binding	GO:0050839	4.5
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
vascular endothelial growth factor-activated receptor activity	GO:0005021	7.79
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
ribonucleotide binding	GO:0032553	2.19
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32