Disease table of HIRSCHSPRUNG DISEASE OMIM ID: PS142623

Gene-disease associations table

Gene	Associated with HIRSCHSPRUNG DISEASE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
NTF3	ClinVar	HGNC link	12p13.31	1	PS142623
SEMA3D	ClinVar	HGNC link	7q21.11	1	PS142623
DPYD	ClinVar	HGNC link	1p21.3	2	274270, PS142623
ZHX2	ClinVar	HGNC link	8q24.13	1	PS142623
AHNAK	ClinVar	HGNC link	11q12.3	1	PS142623
PLAU	ClinVar	HGNC link	10q22.2	3	PS231200, PS142623, 104300
FBN1	ClinVar	HGNC link	15q21.1	9	154700, 102370, 129600, PS277600, PS142623, PS231050, 616914, 604308, 184900
FAT3	ClinVar	HGNC link	11q14.3	1	PS142623
RET	ClinVar, OMIM, HUMSAVAR	HGNC link	10q11.21	6	171300, 155240, PS142623, 209880, 191830, PS131100
KDR	ClinVar	HGNC link	4q12	2	602089, PS142623
GFRA1	ClinVar	HGNC link	10q25.3	1	PS142623
GDNF	ClinVar, OMIM, HUMSAVAR	HGNC link	5p13.2	3	171300, PS142623, 209880
POLR2F	ClinVar	HGNC link	22q13.1	1	PS142623
CNTN5	ClinVar	HGNC link	11q22.1	1	PS142623
THBS4	ClinVar	HGNC link	5q14.1	1	PS142623
IRAK3	ClinVar	HGNC link	12q14.3	2	611064, PS142623
EDNRB	ClinVar, OMIM, HUMSAVAR	HGNC link	13q22.3	3	PS193500, 600501, PS142623
PTCH1	ClinVar	HGNC link	9q22.32	4	605462, 109400, PS142623, PS236100
TSC2	ClinVar	HGNC link	16p13.3	3	PS191100, PS142623, 606690
EDN3	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.32	3	PS193500, PS142623, 209880
CREBBP	ClinVar	HGNC link	16p13.3	2	PS142623, PS180849

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
16p13.3	2	TSC2, CREBBP

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
16p13	2	TSC2, CREBBP

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
16p1	2	TSC2, CREBBP
11q1	2	FAT3, AHNAK
10q2	2	GFRA1, PLAU

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
10q	3	RET, GFRA1, PLAU
11q	3	FAT3, CNTN5, AHNAK
16p	2	TSC2, CREBBP

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	FAT3, CNTN5, AHNAK
10	3	RET, GFRA1, PLAU
12	2	NTF3, IRAK3
16	2	TSC2, CREBBP
5	2	GDNF, THBS4

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
ZHX2	YES	3	CCNE1, AFP, CCNA2	0
CREBBP	YES	27	ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD51	0
HIF1A	NO	80	RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A	2	EDNRB, PLAU
SOX10	NO	11	COL11A2, GJB1, GJC2, NES, PMP22, EDNRB, MBP, MIA, MITF, MPZ, RET	2	EDNRB, RET
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	2	PLAU, GDNF
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	PLAU, GDNF
FOS	NO	56	BATF3, BCL2L1, NPPA, FIGF, ACTA1, FGFBP1, DDIT3, CYP1A2, SMAD4, SLC10A2, MMP9, CCK, PGR, LRIG2, NQO1, FOS, EZR, MMP7, PTGS2, NGF, FAS, FMO4, SMAD7, STAR, CLU, SOX7, PLAU, SRR, NOS2, SPI1, PDHA1, MFI2, MMP1, TP53, OXTR, NPY, GSTP1, NTS, NFKB1, PCK2, CXCL8, CD40LG, CREM, PLAUR, IL1A, ERCC4, MMP3, NTF3, CASP9, CSTA, HSPH1, MYC, CCND1, SPRR3, NEFL, FOXA1	2	NTF3, PLAU
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	4	EDNRB, FBN1, PLAU, KDR
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	2	CREBBP, KDR
ESR1	NO	68	UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B	2	RET, KDR

regulated gene	associated to this disease	# TFs	TFs
NTF3	YES	2	ZNF175, FOS
ZHX2	YES	3	XBP1, ZHX3, MSX1
PLAU	YES	19	SP1, HIF1A, GATA6, RUNX2, EGR1, NFKB1, ATF4, HOXD3, ILF3, SRF, JUN, CREB1, ATF2, RARA, RFWD2, POU2F1, RELA, FOS, ETS1
FBN1	YES	2	SP1, PARP1
RET	YES	5	TFAP2C, SOX9, ESR1, SOX10, FOXA1
KDR	YES	9	SP1, NANOG, PTTG1, SP4, HDAC10, ESR1, SP3, E2F1, HEY1
GDNF	YES	2	NFKB1, EGR1
EDNRB	YES	3	SP1, HIF1A, SOX10
TSC2	YES	1	AR
CREBBP	YES	7	YY1, CLOCK, BCL11B, CIITA, MYC, EP300, E2F1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NTF3	RET	No	1	NTRK1
NTF3	IRAK3	No	1	NTRK3
NTF3	TSC2	No	1	NTRK1
ZHX2	POLR2F	No	1	APP
ZHX2	THBS4	No	1	APP
ZHX2	TSC2	No	2	YWHAQ, YWHAZ
AHNAK	RET	No	3	HNRNPD, GRB2, EGFR
AHNAK	KDR	No	1	GRB2
AHNAK	GDNF	No	1	S100A10
AHNAK	POLR2F	No	1	ESR1
AHNAK	PTCH1	No	2	HSPA5, EGFR
AHNAK	TSC2	No	2	GRB2, ESR1
AHNAK	CREBBP	No	8	RUVBL1, PSME3, RPA2, POT1, CDK2, MYH9, ATF2, ESR1
PLAU	CREBBP	No	2	MYC, ELAVL1
RET	KDR	No	6	PLCG1, CBL, GRB10, SRC, SHC1, GRB2
RET	GFRA1	Yes	2	RET, NRTN
RET	GDNF	No	1	GFRA1
RET	POLR2F	No	1	SRC
RET	IRAK3	No	1	HSP90AA1
RET	PTCH1	No	1	EGFR
RET	TSC2	No	4	NTRK1, GRB2, MAPK1, PTK2
RET	CREBBP	No	6	STAT3, MAPK1, MAPK3, SRC, HIST1H3A, IKBKG
KDR	POLR2F	No	1	SRC
KDR	EDNRB	No	1	CAV1
KDR	PTCH1	No	3	PLXNA1, CAV1, COL18A1
KDR	TSC2	No	3	CAV1, GRB2, RAB5A
KDR	CREBBP	No	1	SRC
GFRA1	GDNF	Yes	0
GDNF	EDNRB	No	1	COPS5
POLR2F	THBS4	No	1	APP
POLR2F	TSC2	No	1	ESR1
POLR2F	CREBBP	No	6	GTF2B, MED25, POLR2A, ESR1, SRC, TAT
IRAK3	CREBBP	No	1	HOXB7
EDNRB	PTCH1	No	1	CAV1
EDNRB	TSC2	No	1	CAV1
EDNRB	EDN3	Yes	0
PTCH1	TSC2	No	2	PAM, CAV1
PTCH1	CREBBP	No	1	FHL2
TSC2	CREBBP	No	8	FOXO1, ESR1, MAPK1, SMAD2, RPS6KA1, CCND3, SMAD3, AKT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
NTF3	ZHX2	No	-	1	HRAS
NTF3	PLAU	No	-	4	PIK3R1, FOS, EGFR, PIK3CA
NTF3	RET	No	-	8	PLCG1, HRAS, CREB1, PIK3R1, PIK3CA, SOS1, SHC1, GRB2
NTF3	KDR	No	-	10	PLCG1, FGF13, BDNF, CREB1, PIK3R1, FGF2, PIK3CA, SOS1, GRB2, SHC1
NTF3	GFRA1	No	-	7	HRAS, CREB1, PIK3R1, PIK3CA, SOS1, GRB2, SHC1
NTF3	GDNF	No	-	9	HRAS, CREB1, PIK3R1, SOS1, PIK3CA, SST, SHC1, FOS, GRB2
NTF3	IRAK3	No	-	1	NGFR
NTF3	EDNRB	No	-	2	PLCG1, FGF2
NTF3	TSC2	No	-	1	YWHAH
NTF3	EDN3	No	-	1	FOS
NTF3	CREBBP	No	-	5	MEF2C, CREB1, FOS, XBP1, TERT
SEMA3D	KDR	No	-	1	NRP1
SEMA3D	TSC2	No	-	1	CCND1
SEMA3D	CREBBP	No	-	1	CCND1
DPYD	AHNAK	No	-	1	UBC
DPYD	RET	No	-	1	UBC
DPYD	KDR	No	-	1	UBC
DPYD	PTCH1	No	-	1	UBC
DPYD	TSC2	No	-	1	UBC
DPYD	CREBBP	No	-	1	UBC
ZHX2	RET	No	-	1	HRAS
ZHX2	GFRA1	No	-	1	HRAS
ZHX2	GDNF	No	-	1	HRAS
ZHX2	PTCH1	No	-	1	GPC3
ZHX2	TSC2	No	-	3	YWHAQ, YWHAB, YWHAZ
AHNAK	RET	No	-	1	UBC
AHNAK	KDR	No	-	1	UBC
AHNAK	PTCH1	No	-	1	UBC
AHNAK	TSC2	No	-	1	UBC
AHNAK	CREBBP	No	-	1	UBC
PLAU	FBN1	No	-	4	ITGA5, ITGB3, ITGAV, ITGB1
PLAU	RET	No	-	5	SRC, MAPK3, PIK3R1, MAPK1, PIK3CA
PLAU	KDR	No	-	9	ITGB3, ITGB1, ITGAV, PIK3R1, PIK3CA, HGF, VIP, SRC, PDGFD
PLAU	GFRA1	No	-	3	SRC, PIK3R1, PIK3CA
PLAU	GDNF	No	-	5	SRC, JUN, FOS, PIK3R1, PIK3CA
PLAU	THBS4	No	-	5	ITGA5, ITGAV, ITGA3, ITGB5, ITGB1
PLAU	EDNRB	No	-	1	MMP9
PLAU	TSC2	No	-	2	MAPK1, MAPK3
PLAU	EDN3	No	-	1	FOS
PLAU	CREBBP	No	-	12	CEBPA, NFKB1, TFDP1, FOSL1, ATF2, JUN, NCL, RELA, SRC, E2F1, FOS, E2F3
FBN1	KDR	No	-	5	ITGAV, ITGB3, HSPG2, DCN, ITGB1
FBN1	THBS4	No	-	4	ITGA5, ITGB6, ITGAV, ITGB1
FBN1	IRAK3	No	-	1	TGFB1
FBN1	CREBBP	No	-	1	CTGF
FAT3	RET	No	-	1	CTNNB1
FAT3	KDR	No	-	1	CTNNB1
FAT3	GFRA1	No	-	1	CTNNB1
FAT3	GDNF	No	-	1	CTNNB1
FAT3	CREBBP	No	-	1	CTNNB1
RET	KDR	No	-	43	PLCG1, WWP1, SH3GLB1, PTPN11, SH3KBP1, SRC, NEDD4L, CREB1, PRKACA, CTNNA1, GRB2, EPN2, CRK, PIK3CA, PTPRJ, CTNNB1, SOS1, SHC1, EPN3, EPN1, EPS15, SMURF1, SH3GL2, MDM2, TRAF6, PHLPP1, SH3GL3, RNF41, PXN, CBLB, SH3GL1, NCK1, SH3GLB2, PHLPP2, CBLC, PIK3R1, BCAR1, ITCH, UBC, IRS1, GAB1, CBL, NEDD4
RET	GFRA1	Yes	binding	36	PTPN11, RASA1, SHANK3, GRB7, PXN, CTNND1, CREB1, RAP1A, PRKACA, CTNNA1, MAPK8, CRK, PIK3CA, CTNNB1, SOS1, SHC1, NRTN, DOK6, HRAS, CDH1, GRB2, DOK1, SRC, GAB1, NCK1, PSPN, GDNF, PDLIM7, IRS1, GRB10, PIK3R1, BCAR1, PRKCA, FRS2, DOK4, DOK5
RET	GDNF	Yes	activation, binding	38	PTPN11, RASA1, SHANK3, GRB7, PXN, CTNND1, CREB1, NRTN, RAP1A, PRKACA, CTNNA1, MAPK8, CRK, GFRA2, PIK3CA, CTNNB1, SOS1, SHC1, PRKCA, HRAS, CDH1, GRB2, DOK1, SRC, GAB1, NCK1, PSPN, PDLIM7, PAX2, IRS1, GRB10, PIK3R1, BCAR1, DOK6, GFRA1, FRS2, DOK4, DOK5
RET	IRAK3	No	-	3	PHLPP2, TRAF6, PHLPP1
RET	EDNRB	No	-	2	MAPK14, PLCG1
RET	PTCH1	No	-	6	SMURF1, WWP1, NEDD4L, ITCH, UBC, NEDD4
RET	TSC2	No	-	5	UBC, MAPK1, MAPK14, MAPK3, RAP1A
RET	CREBBP	No	-	11	STAT3, NKX2-1, MDM2, PTPRF, CREB1, UBC, CTNNB1, SRC, SH3GL1, MAPK14, PRKACA
KDR	GFRA1	No	-	17	PTPN11, NCK1, CTNNA1, PRKACA, CRK, BCAR1, IRS1, PXN, PIK3R1, CREB1, PIK3CA, CTNNB1, SOS1, SRC, SHC1, GAB1, GRB2
KDR	GDNF	No	-	18	PTPN11, CTNNA1, PRKACA, CRK, BCAR1, IRS1, SHC1, PXN, PIK3R1, CREB1, SOS1, CTNNB1, PIK3CA, SRC, GAB1, FGF7, GRB2, NCK1
KDR	THBS4	No	-	5	ITGA1, ITGAV, PDGFB, PTK2, ITGB1
KDR	IRAK3	No	-	4	TRAF6, PHLPP2, CSF2, PHLPP1
KDR	EDNRB	Yes	activation, binding, ptmod	8	NOS3, EDNRA, PLCB1, PLCB2, PLCG1, PGF, FGF2, PLCB3
KDR	PTCH1	No	-	7	SMURF1, WWP1, FGF10, NEDD4L, ITCH, UBC, NEDD4
KDR	TSC2	No	-	3	INS, UBC, VEGFA
KDR	EDN3	No	-	3	EDNRB, EDNRA, HIF1A
KDR	CREBBP	No	-	20	CYP7A1, ARNT, MDM2, UBC, RAC3, HEY1, PRKACA, NOTCH1, CSK, CSF2, EPAS1, IL8, CREB1, MYB, HIF1A, CTNNB1, SRC, SH3GL1, VEGFA, ETS1
GFRA1	GDNF	Yes	activation, binding	38	PTPN11, RASA1, SHANK3, RET, PXN, CTNND1, CREB1, NRTN, RAP1A, PRKACA, NCAM1, CTNNA1, MAPK8, CRK, PIK3CA, CTNNB1, SOS1, SHC1, HRAS, PRKCA, ARTN, CDH1, GRB2, DOK1, SRC, GAB1, NCK1, GRB7, PSPN, PDLIM7, IRS1, GRB10, PIK3R1, BCAR1, DOK6, FRS2, DOK4, DOK5
GFRA1	TSC2	No	-	1	RAP1A
GFRA1	CREBBP	No	-	4	SRC, PRKACA, CREB1, CTNNB1
GDNF	EDNRB	No	-	1	EDN1
GDNF	PTCH1	No	-	1	TGFB2
GDNF	TSC2	No	-	1	RAP1A
GDNF	EDN3	No	-	2	FOS, EDN1
GDNF	CREBBP	No	-	8	CREB1, JUN, CTNNB1, SRC, KAT5, FOS, PRKACA, EDN1
POLR2F	TSC2	No	-	1	MED1
POLR2F	CREBBP	No	-	13	PPARGC1A, GTF2B, GTF2E1, TBP, MED30, MED26, GTF3A, DHX9, MED1, GTF2A1, POLR2A, SNAPC4, GTF2F1
THBS4	CREBBP	No	-	1	CD36
IRAK3	TSC2	No	-	1	AKT1
IRAK3	CREBBP	No	-	4	CSF2, HSPA6, IL1B, AKT1
EDNRB	TSC2	No	-	1	MAPK14
EDNRB	EDN3	Yes	binding	122	P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, GCG, QRFP, GNRH1, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, MITF, XCL2, TRH, GPR132, TACR1, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNA11, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
EDNRB	CREBBP	No	-	5	MAPK14, BDKRB2, AGT, CDH2, EDN1
PTCH1	TSC2	No	-	2	UBC, CDK1
PTCH1	CREBBP	No	-	4	UBC, FGFR1, GLI1, GLI3
TSC2	CREBBP	No	-	21	RPS6KA1, FOXO1, CCND2, AKT1, RPS6KA2, CCND1, RPS6KA3, MED1, TP53, MYC, RPS6KA5, UBC, IKBKB, ADIPOQ, ESR1, SNW1, MAX, MAPK14, VEGFA, LEP, SGK1
EDN3	CREBBP	No	-	6	EGR1, AGT, EDN1, BDKRB2, FOS, HIF1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
KDR	CREBBP	No	-	1	CTNNB1
POLR2F	CREBBP	No	-	6	GTF2B, POLR2A, MED21, GTF2F1, ERCC3, GTF2H3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
RET	GDNF	Yes	2	RET, GDNF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	4	CREBBP, EDNRB, PTCH1, RET
Proteoglycans in cancer	hsa05205	5.02	3	PLAU, PTCH1, KDR
PI3K-Akt signaling pathway	hsa04151	4.21	3	THBS4, KDR, TSC2
Metabolic pathways	hsa01100	2.49	2	POLR2F, DPYD
MicroRNAs in cancer	hsa05206	5.38	2	CREBBP, PLAU
cAMP signaling pathway	hsa04024	5.05	2	CREBBP, PTCH1
Neurotrophin signaling pathway	hsa04722	5.78	2	IRAK3, NTF3
Melanogenesis	hsa04916	5.97	2	EDNRB, CREBBP
Endocytosis	hsa04144	4.92	2	RET, KDR
Focal adhesion	hsa04510	4.92	2	THBS4, KDR
Huntington's disease	hsa05016	5.17	2	POLR2F, CREBBP
Thyroid hormone signaling pathway	hsa04919	5.82	2	CREBBP, TSC2
Pyrimidine metabolism	hsa00240	6.01	2	POLR2F, DPYD
Epstein-Barr virus infection	hsa05169	4.97	2	POLR2F, CREBBP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Pathways in cancer (hsa05200)	-	3.98	0.04	EDNRB, TSC2, KDR, RET, PTCH1, GDNF, CREBBP, ZHX2
Cellular Processes	NEW	2.22	0.032	CREBBP, EDNRB, TSC2, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, POLR2F, RET, ZHX2

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	7	EDNRB, KDR, TSC2, CREBBP, PTCH1, EDN3, THBS4
Developmental Biology	R-HSA-1266738	3.48	5	GFRA1, CREBBP, POLR2F, GDNF, KDR
Innate Immune System	R-HSA-168249	3.17	4	IRAK3, POLR2F, CREBBP, TSC2
Immune System	R-HSA-168256	2.37	4	IRAK3, POLR2F, CREBBP, TSC2
Gene Expression	R-HSA-74160	2.72	3	POLR2F, CREBBP, TSC2
Axon guidance	R-HSA-422475	3.93	3	GFRA1, KDR, GDNF
GPCR ligand binding	R-HSA-500792	4.19	3	EDNRB, PTCH1, EDN3
Signaling by GPCR	R-HSA-372790	2.68	3	EDNRB, PTCH1, EDN3
Disease	R-HSA-1643685	3.33	3	POLR2F, CREBBP, TSC2
Integrin cell surface interactions	R-HSA-216083	6.57	2	FBN1, KDR
Diseases of signal transduction	R-HSA-5663202	4.89	2	CREBBP, TSC2
Generic Transcription Pathway	R-HSA-212436	3.86	2	CREBBP, TSC2
GPCR downstream signaling	R-HSA-388396	3.07	2	EDN3, EDNRB
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69	2	EDN3, EDNRB
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	2	EDNRB, EDN3
Cellular responses to stress	R-HSA-2262752	4.56	2	CREBBP, TSC2
Peptide ligand-binding receptors	R-HSA-375276	5.41	2	EDNRB, EDN3
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	GFRA1, GDNF
NCAM1 interactions	R-HSA-419037	7.59	2	GFRA1, GDNF
Extracellular matrix organization	R-HSA-1474244	4.91	2	FBN1, KDR
Metabolism	R-HSA-1430728	2.34	2	CREBBP, DPYD
G alpha (q) signalling events	R-HSA-416476	5.42	2	EDNRB, EDN3
Signaling by PDGF	R-HSA-186797	4.53	2	THBS4, TSC2
Hemostasis	R-HSA-109582	3.98	2	CREBBP, PLAU
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94	2	POLR2F, CREBBP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Developmental Biology (R-HSA-1266738)	-	3.48	0.005	EDNRB, CNTN5, KDR, RET, CREBBP, PTCH1, FBN1, GDNF, GFRA1, POLR2F, PLAU, ZHX2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	20	THBS4, EDNRB, EDN3, TSC2, AHNAK, IRAK3, CREBBP, PTCH1, NTF3, PLAU, DPYD, FBN1, FAT3, SEMA3D, KDR, GDNF, GFRA1, POLR2F, RET, ZHX2
protein binding (GO:0005515)	0.46	18	TSC2, EDNRB, EDN3, GDNF, AHNAK, RET, IRAK3, PLAU, PTCH1, NTF3, DPYD, FBN1, THBS4, SEMA3D, KDR, GFRA1, CREBBP, ZHX2
receptor binding (GO:0005102)	2.43	11	EDNRB, EDN3, GDNF, KDR, CREBBP, PTCH1, FBN1, NTF3, THBS4, SEMA3D, GFRA1
organic cyclic compound binding (GO:0097159)	1.05	9	KDR, AHNAK, IRAK3, CREBBP, PTCH1, DPYD, POLR2F, RET, ZHX2
cation binding (GO:0043169)	1.4	8	ZHX2, RET, FBN1, IRAK3, DPYD, THBS4, CREBBP, FAT3
metal ion binding (GO:0046872)	1.41	8	ZHX2, RET, FBN1, IRAK3, DPYD, THBS4, CREBBP, FAT3
heterocyclic compound binding (GO:1901363)	1.06	8	KDR, AHNAK, IRAK3, CREBBP, DPYD, POLR2F, RET, ZHX2
ion binding (GO:0043167)	1.36	8	ZHX2, RET, FBN1, IRAK3, DPYD, THBS4, CREBBP, FAT3
catalytic activity (GO:0003824)	1.05	7	KDR, RET, IRAK3, CREBBP, DPYD, POLR2F, PLAU
transferase activity (GO:0016740)	1.95	6	KDR, IRAK3, CREBBP, RET, POLR2F, PLAU
signal transducer activity (GO:0004871)	2.28	6	EDNRB, KDR, CREBBP, PTCH1, GFRA1, RET
signaling receptor activity (GO:0038023)	2.49	5	EDNRB, PTCH1, GFRA1, KDR, RET
carbohydrate derivative binding (GO:0097367)	2.03	5	IRAK3, THBS4, PTCH1, RET, KDR
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	5	IRAK3, PLAU, POLR2F, KDR, RET
small molecule binding (GO:0036094)	1.89	5	IRAK3, RET, PTCH1, DPYD, KDR
molecular transducer activity (GO:0060089)	2.32	5	EDNRB, PTCH1, GFRA1, KDR, RET
transmembrane signaling receptor activity (GO:0004888)	2.57	5	EDNRB, PTCH1, GFRA1, KDR, RET
macromolecular complex binding (GO:0044877)	2.61	5	THBS4, FBN1, PTCH1, CREBBP, KDR
transmembrane receptor activity (GO:0099600)	2.53	5	EDNRB, PTCH1, GFRA1, KDR, RET
receptor activity (GO:0004872)	2.32	5	EDNRB, PTCH1, GFRA1, KDR, RET
protein dimerization activity (GO:0046983)	2.72	5	IRAK3, DPYD, GDNF, TSC2, ZHX2
identical protein binding (GO:0042802)	2.63	5	IRAK3, DPYD, GDNF, TSC2, ZHX2
protein homodimerization activity (GO:0042803)	3.16	5	IRAK3, DPYD, GDNF, TSC2, ZHX2
kinase activity (GO:0016301)	2.93	4	IRAK3, PLAU, RET, KDR
nucleotide binding (GO:0000166)	1.96	4	IRAK3, RET, DPYD, KDR
calcium ion binding (GO:0005509)	3.17	4	THBS4, FBN1, RET, FAT3
nucleic acid binding (GO:0003676)	1.44	4	CREBBP, POLR2F, AHNAK, ZHX2
protein complex binding (GO:0032403)	3.09	4	THBS4, PTCH1, FBN1, KDR
molecular function regulator (GO:0098772)	2.51	4	GFRA1, GDNF, TSC2, RET
nucleoside phosphate binding (GO:1901265)	1.96	4	IRAK3, RET, DPYD, KDR
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	3	GFRA1, RET, GDNF
integrin binding (GO:0005178)	5.07	3	THBS4, FBN1, KDR
growth factor activity (GO:0008083)	4.66	3	THBS4, NTF3, GDNF
adenyl nucleotide binding (GO:0030554)	2.4	3	IRAK3, RET, KDR
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	IRAK3, RET, KDR
ribonucleoside binding (GO:0032549)	2.22	3	IRAK3, RET, KDR
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	3	GFRA1, RET, GDNF
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	3	IRAK3, RET, KDR
adenyl ribonucleotide binding (GO:0032559)	2.41	3	IRAK3, RET, KDR
ribonucleotide binding (GO:0032553)	2.19	3	IRAK3, RET, KDR
purine nucleoside binding (GO:0001883)	2.22	3	IRAK3, RET, KDR
DNA binding (GO:0003677)	1.92	3	POLR2F, CREBBP, ZHX2
purine ribonucleotide binding (GO:0032555)	2.2	3	IRAK3, RET, KDR
purine nucleotide binding (GO:0017076)	2.19	3	IRAK3, RET, KDR
protein kinase activity (GO:0004672)	3.27	3	IRAK3, RET, KDR
cell adhesion molecule binding (GO:0050839)	4.5	3	THBS4, FBN1, KDR
purine ribonucleoside binding (GO:0032550)	2.22	3	IRAK3, RET, KDR
ATP binding (GO:0005524)	2.43	3	IRAK3, RET, KDR
nucleoside binding (GO:0001882)	2.21	3	IRAK3, RET, KDR
sulfur compound binding (GO:1901681)	4.32	2	THBS4, PTCH1
transmembrane receptor protein kinase activity (GO:0019199)	5.32	2	RET, KDR
structural molecule activity (GO:0005198)	3.1	2	FBN1, AHNAK
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	2	CREBBP, ZHX2
growth factor binding (GO:0019838)	4.89	2	NTF3, KDR
transcription cofactor activity (GO:0003712)	3.44	2	CREBBP, ZHX2
glycosaminoglycan binding (GO:0005539)	4.42	2	THBS4, PTCH1
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	5.55	2	RET, KDR
protein tyrosine kinase activity (GO:0004713)	4.54	2	RET, KDR
transcription factor activity, transcription factor binding (GO:0000989)	3.36	2	CREBBP, ZHX2
transcription factor activity, protein binding (GO:0000988)	3.35	2	CREBBP, ZHX2
G-protein coupled receptor binding (GO:0001664)	4.18	2	EDNRB, EDN3
protein heterodimerization activity (GO:0046982)	3.64	2	IRAK3, ZHX2
heparin binding (GO:0008201)	4.68	2	THBS4, PTCH1
structural molecule activity conferring elasticity (GO:0097493)	7.66	2	FBN1, AHNAK
nucleic acid binding transcription factor activity (GO:0001071)	2.65	2	CREBBP, ZHX2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
sulfur compound binding (GO:1901681)	-	4.32	0.0	CNTN5, KDR, PLAU, PTCH1, FBN1, THBS4, RET, ZHX2
growth factor activity (GO:0008083)	-	4.66	0.0	EDNRB, CNTN5, KDR, CREBBP, THBS4, NTF3, GDNF, GFRA1, RET
calcium ion binding (GO:0005509)	-	3.17	0.003	EDNRB, AHNAK, TSC2, CREBBP, THBS4, PLAU, FBN1, GDNF, KDR, RET, FAT3
glial cell-derived neurotrophic factor receptor activity (GO:0016167)	NEW	8.64	0.005	GFRA1, GDNF
enhancer sequence-specific DNA binding (GO:0001158)	NEW	5.36	0.015	EDNRB, CREBBP, GDNF, RET
glycosaminoglycan binding (GO:0005539)	-	4.42	0.002	CNTN5, KDR, RET, PTCH1, FBN1, THBS4, PLAU
transcription regulatory region sequence-specific DNA binding (GO:0000976)	NEW	3.24	0.03	EDNRB, KDR, CREBBP, PTCH1, NTF3, GDNF, RET
enhancer binding (GO:0035326)	NEW	5.21	0.035	EDNRB, CREBBP, GDNF, RET
protein complex binding (GO:0032403)	-	3.09	0.011	CREBBP, TSC2, KDR, RET, PTCH1, FBN1, THBS4, GDNF, GFRA1, PLAU, ZHX2
receptor binding (GO:0005102)	-	2.43	0.008	CREBBP, EDNRB, EDN3, CNTN5, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, GFRA1, POLR2F, RET, ZHX2
protein homodimerization activity (GO:0042803)	-	3.16	0.034	EDNRB, KDR, TSC2, RET, IRAK3, CREBBP, DPYD, GDNF, PLAU, ZHX2
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982)	NEW	3.94	0.025	EDNRB, KDR, CREBBP, NTF3, FBN1, GDNF
cytokine receptor activity (GO:0004896)	NEW	5.24	0.041	EDNRB, GFRA1, GDNF, RET

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	19	TSC2, CREBBP, EDNRB, EDN3, AHNAK, GDNF, KDR, SEMA3D, IRAK3, PLAU, PTCH1, THBS4, NTF3, FBN1, DPYD, GFRA1, POLR2F, RET, ZHX2
biological regulation (GO:0065007)	0.39	18	TSC2, CREBBP, EDNRB, EDN3, AHNAK, GDNF, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, SEMA3D, GFRA1, POLR2F, RET, ZHX2
regulation of biological process (GO:0050789)	0.45	18	CREBBP, EDNRB, EDN3, TSC2, AHNAK, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, SEMA3D, KDR, GDNF, GFRA1, POLR2F, RET, ZHX2
single-organism process (GO:0044699)	0.48	18	CREBBP, EDNRB, EDN3, SEMA3D, TSC2, PLAU, PTCH1, THBS4, NTF3, FBN1, FAT3, DPYD, KDR, GDNF, GFRA1, POLR2F, RET, ZHX2
regulation of cellular process (GO:0050794)	0.5	18	TSC2, CREBBP, EDNRB, EDN3, AHNAK, GDNF, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, SEMA3D, GFRA1, POLR2F, RET, ZHX2
developmental process (GO:0032502)	1.36	17	TSC2, CREBBP, EDNRB, EDN3, GDNF, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, FAT3, SEMA3D, GFRA1, POLR2F, RET, ZHX2
single-organism developmental process (GO:0044767)	1.49	16	EDNRB, EDN3, GDNF, TSC2, RET, CREBBP, PTCH1, NTF3, THBS4, FBN1, ZHX2, SEMA3D, KDR, POLR2F, PLAU, FAT3
regulation of cellular metabolic process (GO:0031323)	1.07	16	EDNRB, EDN3, AHNAK, TSC2, RET, IRAK3, CREBBP, PTCH1, FBN1, NTF3, THBS4, GDNF, KDR, POLR2F, PLAU, ZHX2
regulation of metabolic process (GO:0019222)	1.02	16	TSC2, CREBBP, EDNRB, EDN3, KDR, AHNAK, IRAK3, PLAU, PTCH1, FBN1, NTF3, THBS4, GDNF, POLR2F, RET, ZHX2
regulation of macromolecule metabolic process (GO:0060255)	1.08	15	TSC2, EDNRB, EDN3, KDR, AHNAK, IRAK3, RET, PTCH1, FBN1, NTF3, THBS4, GDNF, POLR2F, CREBBP, ZHX2
single-organism cellular process (GO:0044763)	0.65	15	EDNRB, EDN3, GDNF, KDR, RET, PLAU, PTCH1, DPYD, NTF3, THBS4, FBN1, SEMA3D, GFRA1, POLR2F, CREBBP
regulation of primary metabolic process (GO:0080090)	1.08	15	TSC2, EDNRB, EDN3, KDR, AHNAK, IRAK3, RET, PTCH1, FBN1, NTF3, THBS4, GDNF, POLR2F, CREBBP, ZHX2
negative regulation of biological process (GO:0048519)	1.33	14	EDNRB, GDNF, TSC2, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, SEMA3D, KDR, POLR2F, CREBBP, ZHX2
anatomical structure development (GO:0048856)	1.58	14	EDNRB, EDN3, GDNF, TSC2, PLAU, PTCH1, FBN1, NTF3, THBS4, SEMA3D, KDR, GFRA1, RET, FAT3
regulation of response to stimulus (GO:0048583)	1.54	14	CREBBP, EDNRB, EDN3, KDR, TSC2, IRAK3, PLAU, PTCH1, FBN1, NTF3, THBS4, SEMA3D, GDNF, RET
signal transduction (GO:0007165)	1.28	14	CREBBP, EDNRB, TSC2, KDR, RET, IRAK3, PLAU, PTCH1, EDN3, NTF3, SEMA3D, GDNF, GFRA1, POLR2F
regulation of multicellular organismal process (GO:0051239)	1.87	14	CREBBP, EDNRB, EDN3, GDNF, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, SEMA3D, POLR2F, RET, ZHX2
positive regulation of biological process (GO:0048518)	1.2	13	CREBBP, EDNRB, EDN3, GDNF, KDR, IRAK3, RET, PTCH1, THBS4, NTF3, SEMA3D, POLR2F, PLAU
multicellular organismal process (GO:0032501)	1.45	13	EDNRB, CNTN5, GDNF, KDR, RET, PTCH1, EDN3, THBS4, FAT3, SEMA3D, POLR2F, PLAU, ZHX2
regulation of localization (GO:0032879)	1.94	12	TSC2, EDNRB, EDN3, GDNF, AHNAK, PLAU, PTCH1, THBS4, NTF3, SEMA3D, KDR, RET
single-multicellular organism process (GO:0044707)	1.78	12	EDNRB, GDNF, KDR, PLAU, PTCH1, EDN3, THBS4, ZHX2, SEMA3D, POLR2F, RET, FAT3
cell surface receptor signaling pathway (GO:0007166)	2.09	12	EDNRB, KDR, TSC2, IRAK3, CREBBP, PTCH1, EDN3, NTF3, SEMA3D, GFRA1, POLR2F, RET
positive regulation of cellular process (GO:0048522)	1.3	12	CREBBP, EDNRB, EDN3, GDNF, KDR, PLAU, PTCH1, NTF3, THBS4, SEMA3D, POLR2F, RET
primary metabolic process (GO:0044238)	0.69	11	CREBBP, KDR, IRAK3, PLAU, PTCH1, DPYD, GDNF, GFRA1, POLR2F, RET, ZHX2
positive regulation of metabolic process (GO:0009893)	1.74	11	CREBBP, EDNRB, EDN3, KDR, PLAU, PTCH1, THBS4, NTF3, GDNF, POLR2F, RET
organic substance metabolic process (GO:0071704)	0.63	11	CREBBP, KDR, RET, IRAK3, PLAU, PTCH1, DPYD, GDNF, GFRA1, POLR2F, ZHX2
regulation of developmental process (GO:0050793)	2.1	11	EDNRB, GDNF, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, SEMA3D, RET, ZHX2
positive regulation of cellular metabolic process (GO:0031325)	1.81	11	CREBBP, EDNRB, EDN3, KDR, PLAU, PTCH1, THBS4, NTF3, GDNF, POLR2F, RET
regulation of signal transduction (GO:0009966)	1.84	11	EDN3, KDR, TSC2, RET, IRAK3, CREBBP, PTCH1, FBN1, NTF3, GDNF, PLAU
regulation of multicellular organismal development (GO:2000026)	2.31	11	EDNRB, GDNF, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, SEMA3D, RET, ZHX2
metabolic process (GO:0008152)	0.58	11	CREBBP, KDR, IRAK3, PLAU, PTCH1, DPYD, GDNF, GFRA1, POLR2F, RET, ZHX2
regulation of signaling (GO:0023051)	1.72	11	CREBBP, EDN3, TSC2, KDR, IRAK3, PLAU, PTCH1, FBN1, NTF3, GDNF, RET
regulation of molecular function (GO:0065009)	1.78	11	EDNRB, TSC2, AHNAK, IRAK3, PLAU, PTCH1, EDN3, NTF3, GDNF, GFRA1, RET
regulation of cell communication (GO:0010646)	1.73	11	EDN3, KDR, TSC2, RET, IRAK3, CREBBP, PTCH1, FBN1, NTF3, GDNF, PLAU
regulation of gene expression (GO:0010468)	1.37	11	EDNRB, AHNAK, IRAK3, RET, PTCH1, EDN3, FBN1, GDNF, POLR2F, CREBBP, ZHX2
negative regulation of cellular process (GO:0048523)	1.41	11	EDNRB, SEMA3D, TSC2, IRAK3, CREBBP, PTCH1, NTF3, FBN1, GDNF, KDR, ZHX2
locomotion (GO:0040011)	2.91	10	EDNRB, EDN3, SEMA3D, TSC2, PLAU, NTF3, THBS4, GDNF, KDR, RET
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	10	EDNRB, EDN3, KDR, RET, PTCH1, THBS4, NTF3, GDNF, POLR2F, CREBBP
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	10	EDNRB, AHNAK, IRAK3, RET, PTCH1, FBN1, GDNF, POLR2F, CREBBP, ZHX2
response to stimulus (GO:0050896)	1.22	10	EDNRB, KDR, RET, IRAK3, PLAU, PTCH1, THBS4, FBN1, POLR2F, CREBBP
regulation of RNA metabolic process (GO:0051252)	1.52	10	EDNRB, AHNAK, IRAK3, RET, PTCH1, FBN1, GDNF, POLR2F, CREBBP, ZHX2
regulation of biosynthetic process (GO:0009889)	1.37	10	EDNRB, KDR, IRAK3, RET, PTCH1, FBN1, GDNF, POLR2F, CREBBP, ZHX2
cellular metabolic process (GO:0044237)	0.69	10	KDR, RET, IRAK3, CREBBP, DPYD, GDNF, GFRA1, POLR2F, PLAU, ZHX2
macromolecule metabolic process (GO:0043170)	0.83	10	KDR, IRAK3, PLAU, PTCH1, RET, GDNF, GFRA1, POLR2F, CREBBP, ZHX2
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	10	EDNRB, KDR, IRAK3, RET, PTCH1, FBN1, GDNF, POLR2F, CREBBP, ZHX2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	10	EDNRB, AHNAK, IRAK3, RET, PTCH1, FBN1, GDNF, POLR2F, CREBBP, ZHX2
positive regulation of multicellular organismal process (GO:0051240)	2.49	10	CREBBP, EDNRB, KDR, IRAK3, PLAU, EDN3, NTF3, GDNF, POLR2F, RET
regulation of cell proliferation (GO:0042127)	2.41	9	EDNRB, KDR, TSC2, PLAU, PTCH1, NTF3, EDN3, THBS4, GDNF
cellular response to stimulus (GO:0051716)	1.97	9	CREBBP, EDNRB, KDR, PLAU, PTCH1, FBN1, THBS4, POLR2F, RET
cellular developmental process (GO:0048869)	1.82	9	EDNRB, SEMA3D, KDR, RET, PTCH1, NTF3, EDN3, THBS4, GDNF
regulation of RNA biosynthetic process (GO:2001141)	1.55	9	EDNRB, IRAK3, RET, PTCH1, FBN1, GDNF, POLR2F, CREBBP, ZHX2
cellular component organization (GO:0016043)	1.24	9	AHNAK, KDR, RET, PTCH1, FBN1, NTF3, THBS4, GDNF, CREBBP
regulation of cellular biosynthetic process (GO:0031326)	1.38	9	EDNRB, IRAK3, RET, PTCH1, FBN1, GDNF, POLR2F, CREBBP, ZHX2
regulation of cell differentiation (GO:0045595)	2.42	9	EDNRB, SEMA3D, KDR, RET, PTCH1, NTF3, EDN3, GDNF, ZHX2
response to chemical (GO:0042221)	1.98	9	EDNRB, KDR, RET, IRAK3, CREBBP, PTCH1, THBS4, FBN1, PLAU
system development (GO:0048731)	2.92	9	EDNRB, GDNF, RET, PTCH1, FBN1, NTF3, THBS4, SEMA3D, GFRA1
regulation of biological quality (GO:0065008)	1.68	9	EDNRB, KDR, RET, CREBBP, PTCH1, FBN1, EDN3, GDNF, PLAU
response to organic substance (GO:0010033)	2.2	9	CREBBP, EDNRB, KDR, IRAK3, PLAU, PTCH1, THBS4, FBN1, RET
cellular component organization or biogenesis (GO:0071840)	1.22	9	KDR, AHNAK, CREBBP, PTCH1, NTF3, FBN1, THBS4, GDNF, RET
regulation of phosphorylation (GO:0042325)	2.5	8	EDNRB, EDN3, KDR, TSC2, IRAK3, RET, THBS4, NTF3
regulation of protein phosphorylation (GO:0001932)	2.57	8	EDNRB, EDN3, KDR, TSC2, IRAK3, RET, THBS4, NTF3
cell migration (GO:0016477)	3.12	8	EDNRB, GDNF, KDR, PLAU, EDN3, THBS4, SEMA3D, RET
negative regulation of metabolic process (GO:0009892)	1.93	8	EDNRB, TSC2, IRAK3, CREBBP, PTCH1, NTF3, POLR2F, ZHX2
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	8	EDNRB, TSC2, IRAK3, CREBBP, PTCH1, NTF3, POLR2F, ZHX2
cellular macromolecule metabolic process (GO:0044260)	0.93	8	CREBBP, KDR, IRAK3, RET, GDNF, GFRA1, POLR2F, ZHX2
cell motility (GO:0048870)	3.02	8	EDNRB, SEMA3D, KDR, PLAU, EDN3, THBS4, GDNF, RET
protein metabolic process (GO:0019538)	1.45	8	CREBBP, KDR, IRAK3, RET, PTCH1, GDNF, GFRA1, PLAU
regulation of protein metabolic process (GO:0051246)	1.93	8	EDNRB, EDN3, KDR, TSC2, IRAK3, RET, THBS4, NTF3
regulation of catalytic activity (GO:0050790)	1.97	8	EDNRB, TSC2, IRAK3, RET, EDN3, NTF3, GDNF, GFRA1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	8	EDNRB, IRAK3, RET, PTCH1, FBN1, GDNF, CREBBP, ZHX2
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	8	EDNRB, IRAK3, RET, PTCH1, FBN1, GDNF, CREBBP, ZHX2
regulation of cellular component organization (GO:0051128)	2.01	8	SEMA3D, TSC2, IRAK3, RET, NTF3, EDN3, GDNF, KDR
regulation of phosphorus metabolic process (GO:0051174)	2.35	8	EDNRB, EDN3, KDR, TSC2, IRAK3, RET, THBS4, NTF3
regulation of transcription, DNA-templated (GO:0006355)	1.56	8	EDNRB, IRAK3, RET, PTCH1, FBN1, GDNF, CREBBP, ZHX2
regulation of cellular protein metabolic process (GO:0032268)	1.99	8	EDNRB, EDN3, KDR, TSC2, IRAK3, RET, THBS4, NTF3
regulation of protein modification process (GO:0031399)	2.32	8	EDNRB, KDR, TSC2, IRAK3, RET, EDN3, NTF3, THBS4
regulation of phosphate metabolic process (GO:0019220)	2.35	8	EDNRB, KDR, TSC2, IRAK3, RET, EDN3, NTF3, THBS4
movement of cell or subcellular component (GO:0006928)	2.61	8	EDNRB, GDNF, KDR, PLAU, THBS4, EDN3, SEMA3D, RET
positive regulation of cell proliferation (GO:0008284)	3.01	7	EDNRB, KDR, PLAU, NTF3, EDN3, THBS4, GDNF
positive regulation of cellular component movement (GO:0051272)	3.71	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
positive regulation of cell migration (GO:0030335)	3.77	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
regulation of locomotion (GO:0040012)	3.12	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
positive regulation of cell motility (GO:2000147)	3.74	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
positive regulation of locomotion (GO:0040017)	3.71	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
regulation of response to external stimulus (GO:0032101)	3.06	7	EDNRB, KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D
regulation of transport (GO:0051049)	2.24	7	EDNRB, AHNAK, TSC2, PTCH1, EDN3, NTF3, GDNF
negative regulation of response to stimulus (GO:0048585)	2.52	7	SEMA3D, TSC2, IRAK3, PLAU, PTCH1, FBN1, GDNF
negative regulation of multicellular organismal process (GO:0051241)	2.84	7	EDNRB, IRAK3, PLAU, PTCH1, THBS4, SEMA3D, ZHX2
negative regulation of cellular metabolic process (GO:0031324)	2.01	7	EDNRB, TSC2, IRAK3, CREBBP, PTCH1, NTF3, ZHX2
regulation of intracellular signal transduction (GO:1902531)	2.31	7	KDR, TSC2, IRAK3, CREBBP, EDN3, NTF3, RET
positive regulation of response to stimulus (GO:0048584)	2.18	7	KDR, IRAK3, RET, EDN3, NTF3, THBS4, CREBBP
regulation of cellular component movement (GO:0051270)	3.08	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
regulation of cell motility (GO:2000145)	3.16	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
positive regulation of molecular function (GO:0044093)	2.23	7	TSC2, IRAK3, RET, EDN3, NTF3, GDNF, GFRA1
nervous system development (GO:0007399)	3.53	7	EDNRB, SEMA3D, RET, THBS4, NTF3, GDNF, GFRA1
intracellular signal transduction (GO:0035556)	2.39	7	EDNRB, KDR, TSC2, RET, EDN3, GDNF, GFRA1
anatomical structure morphogenesis (GO:0009653)	2.53	7	RET, PTCH1, FBN1, NTF3, THBS4, GDNF, CREBBP
regulation of cell migration (GO:0030334)	3.23	7	KDR, PLAU, NTF3, EDN3, THBS4, SEMA3D, RET
positive regulation of biosynthetic process (GO:0009891)	2.29	6	KDR, CREBBP, PTCH1, GDNF, POLR2F, RET
phosphorylation (GO:0016310)	2.63	6	KDR, IRAK3, PLAU, GDNF, GFRA1, RET
cell differentiation (GO:0030154)	2.14	6	EDNRB, KDR, RET, PTCH1, EDN3, SEMA3D
cellular response to chemical stimulus (GO:0070887)	2.57	6	EDNRB, KDR, PLAU, PTCH1, FBN1, RET
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	6	TSC2, KDR, RET, NTF3, POLR2F, GFRA1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	6	TSC2, KDR, RET, NTF3, POLR2F, GFRA1
ameboidal-type cell migration (GO:0001667)	4.71	6	EDNRB, SEMA3D, KDR, RET, EDN3, GDNF
regulation of cell death (GO:0010941)	2.43	6	EDNRB, KDR, CREBBP, NTF3, GDNF, RET
regulation of apoptotic process (GO:0042981)	2.5	6	EDNRB, KDR, CREBBP, NTF3, GDNF, RET
positive regulation of catalytic activity (GO:0043085)	2.4	6	TSC2, RET, EDN3, NTF3, GDNF, GFRA1
cellular protein metabolic process (GO:0044267)	1.63	6	KDR, IRAK3, CREBBP, GDNF, GFRA1, RET
single-organism metabolic process (GO:0044710)	1.63	6	KDR, RET, DPYD, GDNF, GFRA1, CREBBP
taxis (GO:0042330)	4.03	6	EDNRB, TSC2, PLAU, EDN3, NTF3, SEMA3D
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	6	EDNRB, KDR, RET, EDN3, NTF3, THBS4
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	6	SEMA3D, KDR, PLAU, THBS4, GDNF, RET
positive regulation of protein metabolic process (GO:0051247)	2.43	6	EDNRB, KDR, RET, EDN3, NTF3, THBS4
regulation of cell development (GO:0060284)	3.01	6	EDNRB, SEMA3D, RET, NTF3, GDNF, ZHX2
phosphate-containing compound metabolic process (GO:0006796)	2.16	6	KDR, IRAK3, RET, GDNF, GFRA1, PLAU
regulation of programmed cell death (GO:0043067)	2.49	6	EDNRB, KDR, CREBBP, NTF3, GDNF, RET
animal organ development (GO:0048513)	2.53	6	KDR, TSC2, RET, PTCH1, FBN1, GDNF
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	6	EDNRB, KDR, RET, EDN3, NTF3, THBS4
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	6	KDR, TSC2, RET, PTCH1, GDNF, PLAU
chemotaxis (GO:0006935)	4.04	6	EDNRB, TSC2, PLAU, EDN3, NTF3, SEMA3D
positive regulation of phosphate metabolic process (GO:0045937)	2.78	6	EDNRB, KDR, RET, EDN3, NTF3, THBS4
cellular protein modification process (GO:0006464)	1.79	6	KDR, IRAK3, CREBBP, GDNF, GFRA1, RET
cellular response to organic substance (GO:0071310)	2.78	6	EDNRB, KDR, RET, PTCH1, FBN1, PLAU
positive regulation of cell differentiation (GO:0045597)	3.01	6	KDR, RET, PTCH1, EDN3, NTF3, GDNF
macromolecule modification (GO:0043412)	1.73	6	KDR, IRAK3, CREBBP, GDNF, GFRA1, RET
protein modification process (GO:0036211)	1.79	6	KDR, IRAK3, CREBBP, GDNF, GFRA1, RET
response to oxygen-containing compound (GO:1901700)	2.57	6	EDNRB, IRAK3, RET, PTCH1, FBN1, PLAU
positive regulation of phosphorylation (GO:0042327)	2.9	6	EDNRB, KDR, RET, EDN3, NTF3, THBS4
positive regulation of developmental process (GO:0051094)	2.77	6	KDR, IRAK3, RET, PTCH1, NTF3, GDNF
positive regulation of protein modification process (GO:0031401)	2.7	6	EDNRB, KDR, RET, EDN3, NTF3, THBS4
response to stress (GO:0006950)	1.8	6	EDNRB, RET, CREBBP, THBS4, POLR2F, PLAU
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	6	KDR, CREBBP, PTCH1, GDNF, POLR2F, RET
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	6	EDNRB, CREBBP, PTCH1, FBN1, GDNF, ZHX2
phosphorus metabolic process (GO:0006793)	2.15	6	KDR, IRAK3, PLAU, GDNF, GFRA1, RET
positive regulation of protein phosphorylation (GO:0001934)	2.95	6	EDNRB, KDR, RET, EDN3, NTF3, THBS4
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	5	CREBBP, RET, PTCH1, POLR2F, GDNF
immune system process (GO:0002376)	2.29	5	IRAK3, CREBBP, EDNRB, EDN3, RET
homeostatic process (GO:0042592)	2.61	5	CREBBP, PLAU, EDN3, PTCH1, EDNRB
negative regulation of signaling (GO:0023057)	2.65	5	IRAK3, FBN1, PTCH1, GDNF, TSC2
negative regulation of gene expression (GO:0010629)	2.48	5	CREBBP, EDNRB, PTCH1, POLR2F, ZHX2
positive regulation of gene expression (GO:0010628)	2.35	5	CREBBP, POLR2F, PTCH1, RET, GDNF
regulation of chemotaxis (GO:0050920)	4.53	5	THBS4, EDN3, NTF3, SEMA3D, KDR
negative regulation of cell communication (GO:0010648)	2.66	5	IRAK3, FBN1, PTCH1, GDNF, TSC2
positive regulation of cell communication (GO:0010647)	2.41	5	CREBBP, EDN3, NTF3, KDR, RET
regulation of GTPase activity (GO:0043087)	3.21	5	GFRA1, GDNF, NTF3, TSC2, RET
multicellular organism development (GO:0007275)	2.54	5	EDN3, PTCH1, SEMA3D, FAT3, KDR
regulation of neurogenesis (GO:0050767)	3.21	5	EDNRB, RET, NTF3, ZHX2, SEMA3D
positive regulation of GTPase activity (GO:0043547)	3.28	5	NTF3, GDNF, GFRA1, TSC2, RET
negative regulation of signal transduction (GO:0009968)	2.75	5	IRAK3, FBN1, PTCH1, GDNF, TSC2
positive regulation of signal transduction (GO:0009967)	2.5	5	CREBBP, EDN3, NTF3, KDR, RET
regulation of neuron differentiation (GO:0045664)	3.39	5	EDNRB, RET, NTF3, ZHX2, SEMA3D
biological adhesion (GO:0022610)	2.81	5	CREBBP, THBS4, CNTN5, RET, FAT3
positive regulation of cellular component organization (GO:0051130)	2.68	5	EDN3, GDNF, NTF3, KDR, RET
negative regulation of developmental process (GO:0051093)	3.17	5	THBS4, EDNRB, PTCH1, SEMA3D, ZHX2
protein phosphorylation (GO:0006468)	2.89	5	IRAK3, GFRA1, GDNF, RET, KDR
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	5	POLR2F, CREBBP, PTCH1, RET, GDNF
positive regulation of transport (GO:0051050)	2.9	5	NTF3, EDN3, PTCH1, EDNRB, GDNF
tissue development (GO:0009888)	3.27	5	RET, GDNF, PTCH1, PLAU, KDR
cell adhesion (GO:0007155)	2.82	5	THBS4, CNTN5, CREBBP, FAT3, RET
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	5	POLR2F, RET, PTCH1, CREBBP, GDNF
neural crest cell migration (GO:0001755)	5.76	5	EDNRB, GDNF, EDN3, SEMA3D, RET
localization (GO:0051179)	1.4	5	EDNRB, FBN1, PTCH1, EDN3, TSC2
positive regulation of signaling (GO:0023056)	2.41	5	CREBBP, EDN3, NTF3, KDR, RET
regulation of hydrolase activity (GO:0051336)	2.53	5	NTF3, GDNF, GFRA1, TSC2, RET
cellular response to oxygen-containing compound (GO:1901701)	3.22	5	EDNRB, FBN1, PTCH1, RET, PLAU
regulation of epithelial cell proliferation (GO:0050678)	4.06	5	THBS4, EDNRB, PTCH1, PLAU, KDR
positive regulation of hydrolase activity (GO:0051345)	2.91	5	NTF3, GDNF, GFRA1, TSC2, RET
positive regulation of RNA metabolic process (GO:0051254)	2.51	5	POLR2F, RET, PTCH1, CREBBP, GDNF
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	5	CREBBP, POLR2F, PTCH1, RET, GDNF
regulation of nervous system development (GO:0051960)	3.1	5	EDNRB, RET, NTF3, ZHX2, SEMA3D
response to lipid (GO:0033993)	3.11	5	IRAK3, EDNRB, PTCH1, RET, PLAU
regulation of cell morphogenesis (GO:0022604)	3.4	4	RET, GDNF, KDR, SEMA3D
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	4	IRAK3, EDNRB, NTF3, TSC2
positive regulation of response to external stimulus (GO:0032103)	4.17	4	THBS4, EDN3, NTF3, KDR
negative regulation of biosynthetic process (GO:0009890)	2.47	4	EDNRB, PTCH1, CREBBP, ZHX2
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	4	EDNRB, PTCH1, CREBBP, ZHX2
tube formation (GO:0035148)	4.98	4	RET, PTCH1, GDNF, TSC2
cellular biosynthetic process (GO:0044249)	1.37	4	POLR2F, DPYD, CREBBP, ZHX2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	4	POLR2F, DPYD, CREBBP, ZHX2
nitrogen compound metabolic process (GO:0006807)	1.13	4	POLR2F, DPYD, CREBBP, ZHX2
positive regulation of chemotaxis (GO:0050921)	4.94	4	THBS4, EDN3, NTF3, KDR
cellular aromatic compound metabolic process (GO:0006725)	1.3	4	POLR2F, DPYD, CREBBP, ZHX2
organic substance biosynthetic process (GO:1901576)	1.34	4	POLR2F, DPYD, CREBBP, ZHX2
response to organic cyclic compound (GO:0014070)	3.07	4	IRAK3, EDNRB, PTCH1, PLAU
regulation of MAPK cascade (GO:0043408)	3.22	4	IRAK3, EDN3, NTF3, KDR
nucleobase-containing compound metabolic process (GO:0006139)	1.35	4	POLR2F, DPYD, CREBBP, ZHX2
negative regulation of protein metabolic process (GO:0051248)	2.82	4	IRAK3, EDNRB, NTF3, TSC2
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	4	EDNRB, PTCH1, CREBBP, ZHX2
heterocycle metabolic process (GO:0046483)	1.31	4	POLR2F, DPYD, CREBBP, ZHX2
regulation of kinase activity (GO:0043549)	3.07	4	IRAK3, EDN3, NTF3, TSC2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	4	EDNRB, PTCH1, CREBBP, ZHX2
interspecies interaction between organisms (GO:0044419)	3.08	4	IRAK3, CREBBP, KDR, TSC2
positive regulation of immune system process (GO:0002684)	2.96	4	IRAK3, CREBBP, THBS4, EDN3
negative regulation of apoptotic process (GO:0043066)	3.04	4	EDNRB, NTF3, GDNF, KDR
regulation of immune system process (GO:0002682)	2.5	4	IRAK3, CREBBP, EDN3, THBS4
organic cyclic compound metabolic process (GO:1901360)	1.26	4	POLR2F, DPYD, CREBBP, ZHX2
transport (GO:0006810)	1.51	4	EDNRB, PTCH1, EDN3, TSC2
negative regulation of molecular function (GO:0044092)	2.74	4	IRAK3, EDNRB, PTCH1, TSC2
signal transduction by protein phosphorylation (GO:0023014)	3.79	4	GFRA1, GDNF, KDR, RET
system process (GO:0003008)	2.3	4	EDN3, CNTN5, EDNRB, GDNF
negative regulation of programmed cell death (GO:0043069)	3.02	4	EDNRB, NTF3, GDNF, KDR
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	4	RET, PTCH1, CREBBP, GDNF
epithelium development (GO:0060429)	4.57	4	RET, PTCH1, KDR, GDNF
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	4	EDNRB, PTCH1, CREBBP, ZHX2
viral process (GO:0016032)	3.15	4	IRAK3, CREBBP, KDR, TSC2
negative regulation of phosphate metabolic process (GO:0045936)	3.45	4	IRAK3, EDNRB, NTF3, TSC2
cell-cell adhesion (GO:0098609)	3.34	4	THBS4, CREBBP, FAT3, RET
negative regulation of cell death (GO:0060548)	2.95	4	EDNRB, NTF3, GDNF, KDR
regulation of protein kinase activity (GO:0045859)	3.15	4	IRAK3, EDN3, NTF3, TSC2
cellular response to lipid (GO:0071396)	3.96	4	EDNRB, PTCH1, PLAU, RET
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	4	EDNRB, PTCH1, CREBBP, ZHX2
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	4	EDNRB, PTCH1, CREBBP, ZHX2
negative regulation of cell differentiation (GO:0045596)	3.33	4	EDNRB, PTCH1, SEMA3D, ZHX2
single-organism transport (GO:0044765)	2.18	4	EDNRB, PTCH1, EDN3, TSC2
multi-organism cellular process (GO:0044764)	3.14	4	IRAK3, CREBBP, KDR, TSC2
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	4	EDNRB, PTCH1, CREBBP, ZHX2
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	4	CREBBP, PTCH1, RET, GDNF
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	4	EDNRB, PTCH1, CREBBP, ZHX2
positive regulation of intracellular signal transduction (GO:1902533)	2.95	4	CREBBP, EDN3, NTF3, KDR
establishment of localization (GO:0051234)	1.48	4	EDNRB, PTCH1, EDN3, TSC2
negative regulation of RNA metabolic process (GO:0051253)	2.66	4	EDNRB, PTCH1, CREBBP, ZHX2
single-organism localization (GO:1902578)	2.09	4	EDNRB, PTCH1, EDN3, TSC2
multi-organism process (GO:0051704)	2.65	4	IRAK3, CREBBP, KDR, TSC2
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	4	IRAK3, EDNRB, NTF3, TSC2
response to external stimulus (GO:0009605)	2.55	4	IRAK3, EDNRB, PTCH1, PLAU
regulation of cell cycle (GO:0051726)	2.93	4	EDN3, PTCH1, CREBBP, TSC2
regulation of response to stress (GO:0080134)	2.53	4	IRAK3, EDNRB, CREBBP, PLAU
biosynthetic process (GO:0009058)	1.32	4	POLR2F, DPYD, CREBBP, ZHX2
regulation of transferase activity (GO:0051338)	2.88	4	IRAK3, EDN3, NTF3, TSC2
chemical homeostasis (GO:0048878)	2.97	4	EDNRB, PTCH1, EDN3, PLAU
cellular response to stress (GO:0033554)	2.51	4	CREBBP, THBS4, POLR2F, PLAU
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	4	IRAK3, CREBBP, KDR, TSC2
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	4	EDNRB, PTCH1, CREBBP, ZHX2
cellular homeostasis (GO:0019725)	3.23	3	EDNRB, EDN3, PLAU
response to nitrogen compound (GO:1901698)	3.12	3	IRAK3, PLAU, FBN1
cellular component assembly (GO:0022607)	2.14	3	THBS4, CREBBP, AHNAK
RNA biosynthetic process (GO:0032774)	1.84	3	POLR2F, CREBBP, ZHX2
regulation of secretion (GO:0051046)	3.2	3	EDNRB, EDN3, GDNF
positive regulation of secretion (GO:0051047)	3.85	3	EDNRB, EDN3, GDNF
cell projection organization (GO:0030030)	3.14	3	THBS4, NTF3, GDNF
regulation of cell adhesion (GO:0030155)	3.27	3	RET, PLAU, KDR
cellular macromolecule biosynthetic process (GO:0034645)	1.66	3	POLR2F, CREBBP, ZHX2
kidney development (GO:0001822)	4.79	3	RET, FBN1, GDNF
nucleic acid metabolic process (GO:0090304)	1.46	3	POLR2F, CREBBP, ZHX2
leukocyte migration (GO:0050900)	4.19	3	EDN3, EDNRB, RET
peptidyl-amino acid modification (GO:0018193)	2.98	3	RET, CREBBP, KDR
second-messenger-mediated signaling (GO:0019932)	4.65	3	EDN3, EDNRB, KDR
negative regulation of cell development (GO:0010721)	4.02	3	EDNRB, SEMA3D, ZHX2
response to lipopolysaccharide (GO:0032496)	4.03	3	IRAK3, EDNRB, PLAU
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	3	IRAK3, EDN3, NTF3
organic cyclic compound biosynthetic process (GO:1901362)	1.66	3	POLR2F, CREBBP, ZHX2
negative regulation of catalytic activity (GO:0043086)	3.0	3	IRAK3, EDNRB, TSC2
regulation of defense response (GO:0031347)	3.11	3	IRAK3, EDNRB, CREBBP
response to endogenous stimulus (GO:0009719)	2.79	3	IRAK3, PLAU, FBN1
macromolecular complex assembly (GO:0065003)	2.55	3	THBS4, CREBBP, AHNAK
regulation of mitotic cell cycle (GO:0007346)	3.71	3	EDN3, PTCH1, CREBBP
neuron differentiation (GO:0030182)	4.17	3	EDN3, PTCH1, RET
response to external biotic stimulus (GO:0043207)	3.13	3	IRAK3, EDNRB, PLAU
cellular response to growth factor stimulus (GO:0071363)	4.27	3	PLAU, FBN1, KDR
regulation of organelle organization (GO:0033043)	2.72	3	EDN3, NTF3, KDR
MAPK cascade (GO:0000165)	3.91	3	GFRA1, RET, GDNF
response to growth factor (GO:0070848)	4.14	3	PLAU, FBN1, KDR
negative regulation of neurogenesis (GO:0050768)	4.22	3	EDNRB, SEMA3D, ZHX2
regulation of anatomical structure size (GO:0090066)	3.78	3	EDNRB, EDN3, RET
negative regulation of neuron differentiation (GO:0045665)	4.45	3	EDNRB, SEMA3D, ZHX2
macromolecular complex subunit organization (GO:0043933)	2.14	3	THBS4, CREBBP, AHNAK
regulation of cell morphogenesis involved in differentiation (GO:0010769)	3.91	3	RET, SEMA3D, GDNF
nucleic acid-templated transcription (GO:0097659)	1.91	3	POLR2F, CREBBP, ZHX2
positive regulation of cell development (GO:0010720)	3.57	3	NTF3, RET, GDNF
organic substance transport (GO:0071702)	2.15	3	EDN3, PTCH1, TSC2
proteolysis (GO:0006508)	2.73	3	PLAU, PTCH1, RET
heterocycle biosynthetic process (GO:0018130)	1.7	3	POLR2F, CREBBP, ZHX2
embryonic morphogenesis (GO:0048598)	3.72	3	CREBBP, PTCH1, FBN1
embryonic epithelial tube formation (GO:0001838)	6.4	3	RET, PTCH1, GDNF
tissue morphogenesis (GO:0048729)	3.87	3	RET, PTCH1, GDNF
muscle contraction (GO:0006936)	4.37	3	EDNRB, EDN3, GDNF
response to abiotic stimulus (GO:0009628)	2.8	3	CREBBP, PTCH1, PLAU
phasic smooth muscle contraction (GO:0014821)	6.96	3	EDNRB, EDN3, GDNF
smooth muscle contraction (GO:0006939)	5.9	3	EDN3, EDNRB, GDNF
protein complex assembly (GO:0006461)	2.78	3	THBS4, CREBBP, AHNAK
positive regulation of MAPK cascade (GO:0043410)	3.57	3	EDN3, NTF3, KDR
regulation of multi-organism process (GO:0043900)	3.6	3	EDNRB, POLR2F, PLAU
macromolecule biosynthetic process (GO:0009059)	1.61	3	POLR2F, CREBBP, ZHX2
metanephros development (GO:0001656)	6.02	3	RET, FBN1, GDNF
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	3	POLR2F, CREBBP, ZHX2
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	3	POLR2F, CREBBP, ZHX2
cellular chemical homeostasis (GO:0055082)	3.4	3	EDNRB, EDN3, PLAU
cellular component morphogenesis (GO:0032989)	3.5	3	THBS4, NTF3, GDNF
negative regulation of protein phosphorylation (GO:0001933)	3.79	3	IRAK3, NTF3, TSC2
epithelial tube formation (GO:0072175)	6.36	3	RET, PTCH1, GDNF
RNA metabolic process (GO:0016070)	1.59	3	POLR2F, CREBBP, ZHX2
positive regulation of multi-organism process (GO:0043902)	4.68	3	EDNRB, POLR2F, PLAU
negative regulation of phosphorylation (GO:0042326)	3.7	3	IRAK3, NTF3, TSC2
response to biotic stimulus (GO:0009607)	3.09	3	IRAK3, EDNRB, PLAU
protein complex subunit organization (GO:0071822)	2.6	3	THBS4, CREBBP, AHNAK
response to organonitrogen compound (GO:0010243)	3.2	3	IRAK3, PLAU, FBN1
positive regulation of organelle organization (GO:0010638)	3.38	3	EDN3, NTF3, KDR
muscle system process (GO:0003012)	4.18	3	EDN3, EDNRB, GDNF
regulation of cytokine production (GO:0001817)	3.4	3	IRAK3, POLR2F, CREBBP
negative regulation of nervous system development (GO:0051961)	4.15	3	EDNRB, SEMA3D, ZHX2
response to molecule of bacterial origin (GO:0002237)	3.99	3	IRAK3, EDNRB, PLAU
transcription, DNA-templated (GO:0006351)	1.91	3	POLR2F, CREBBP, ZHX2
enteric nervous system development (GO:0048484)	7.33	3	EDNRB, RET, GDNF
aromatic compound biosynthetic process (GO:0019438)	1.7	3	POLR2F, CREBBP, ZHX2
regulation of MAP kinase activity (GO:0043405)	3.95	3	IRAK3, EDN3, NTF3
negative regulation of protein modification process (GO:0031400)	3.4	3	IRAK3, NTF3, TSC2
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	RET, GDNF
protein localization (GO:0008104)	2.36	2	PTCH1, TSC2
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	RET, GDNF
positive regulation of reproductive process (GO:2000243)	5.8	2	EDNRB, PLAU
regulation of reproductive process (GO:2000241)	4.88	2	EDNRB, PLAU
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239)	5.86	2	RET, GDNF
behavior (GO:0007610)	3.47	2	THBS4, GDNF
regulation of homeostatic process (GO:0032844)	3.65	2	EDNRB, KDR
positive regulation of defense response (GO:0031349)	3.83	2	IRAK3, CREBBP
membrane organization (GO:0061024)	3.04	2	PTCH1, GDNF
regulation of positive chemotaxis (GO:0050926)	6.55	2	NTF3, KDR
circulatory system process (GO:0003013)	4.38	2	EDN3, EDNRB
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	NTF3, GDNF
calcium ion homeostasis (GO:0055074)	3.97	2	EDN3, EDNRB
cell chemotaxis (GO:0060326)	4.63	2	EDN3, EDNRB
inorganic ion homeostasis (GO:0098771)	3.43	2	EDN3, EDNRB
regulation of ion transmembrane transport (GO:0034765)	3.77	2	EDN3, AHNAK
regulation of cell projection organization (GO:0031344)	3.38	2	RET, SEMA3D
regulation of transmembrane transport (GO:0034762)	3.74	2	EDN3, AHNAK
response to pain (GO:0048265)	6.78	2	EDNRB, RET
positive regulation of cell cycle (GO:0045787)	3.94	2	EDN3, CREBBP
positive regulation of cell adhesion (GO:0045785)	3.79	2	RET, KDR
single-organism behavior (GO:0044708)	3.79	2	THBS4, GDNF
peptidyl-tyrosine modification (GO:0018212)	4.47	2	RET, KDR
positive regulation of metanephros development (GO:0072216)	7.09	2	RET, GDNF
regulation of epithelial cell differentiation (GO:0030856)	4.96	2	PTCH1, GDNF
response to acid chemical (GO:0001101)	4.05	2	RET, PTCH1
positive regulation of epithelial cell differentiation (GO:0030858)	5.76	2	PTCH1, GDNF
macromolecule localization (GO:0033036)	2.34	2	PTCH1, TSC2
positive regulation of positive chemotaxis (GO:0050927)	6.59	2	NTF3, KDR
vascular smooth muscle contraction (GO:0014829)	7.16	2	EDNRB, EDN3
leukocyte chemotaxis (GO:0030595)	4.96	2	EDNRB, EDN3
cellular response to molecule of bacterial origin (GO:0071219)	4.88	2	EDNRB, PLAU
single organism signaling (GO:0044700)	3.25	2	EDN3, NTF3
carbohydrate homeostasis (GO:0033500)	4.6	2	PLAU, PTCH1
pigment cell differentiation (GO:0050931)	6.64	2	EDNRB, EDN3
sensory perception (GO:0007600)	2.93	2	EDNRB, CNTN5
vein smooth muscle contraction (GO:0014826)	8.34	2	EDN3, EDNRB
establishment of protein localization (GO:0045184)	2.53	2	PTCH1, TSC2
regulation of immune response (GO:0050776)	2.98	2	IRAK3, CREBBP
regulation of neuron projection development (GO:0010975)	3.69	2	RET, SEMA3D
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)	4.82	2	IRAK3, PTCH1
cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)	4.39	2	RET, FAT3
positive regulation of epithelial cell proliferation (GO:0050679)	4.67	2	THBS4, KDR
cellular calcium ion homeostasis (GO:0006874)	4.01	2	EDNRB, EDN3
stem cell population maintenance (GO:0019827)	4.83	2	POLR2F, ZHX2
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	4.62	2	THBS4, NTF3
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	2	THBS4, NTF3
cellular response to lipopolysaccharide (GO:0071222)	4.94	2	EDNRB, PLAU
cellular macromolecule localization (GO:0070727)	3.1	2	PTCH1, TSC2
cell communication (GO:0007154)	3.04	2	EDN3, NTF3
regulation of neuron apoptotic process (GO:0043523)	4.47	2	NTF3, GDNF
multicellular organismal response to stress (GO:0033555)	5.67	2	EDNRB, RET
aromatic compound catabolic process (GO:0019439)	3.79	2	DPYD, ZHX2
negative regulation of kinase activity (GO:0033673)	4.22	2	IRAK3, TSC2
positive regulation of kinase activity (GO:0033674)	3.54	2	EDN3, NTF3
embryonic organ development (GO:0048568)	4.86	2	PTCH1, KDR
positive regulation of kidney development (GO:0090184)	6.02	2	RET, GDNF
regulation of kidney development (GO:0090183)	5.72	2	RET, GDNF
muscle cell migration (GO:0014812)	6.84	2	THBS4, PLAU
positive regulation of immune response (GO:0050778)	3.4	2	IRAK3, CREBBP
vascular process in circulatory system (GO:0003018)	4.65	2	EDNRB, EDN3
regulation of vasculature development (GO:1901342)	4.26	2	THBS4, KDR
morphogenesis of a branching structure (GO:0001763)	4.71	2	PTCH1, GDNF
vasoconstriction (GO:0042310)	6.36	2	EDNRB, EDN3
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	EDN3, NTF3
regulation of cation transmembrane transport (GO:1904062)	4.4	2	EDN3, AHNAK
positive regulation of cell cycle process (GO:0090068)	4.25	2	EDN3, CREBBP
organic substance catabolic process (GO:1901575)	2.45	2	DPYD, ZHX2
positive regulation of transferase activity (GO:0051347)	3.31	2	EDN3, NTF3
immune response-regulating signaling pathway (GO:0002764)	3.72	2	IRAK3, CREBBP
intracellular protein transport (GO:0006886)	3.2	2	PTCH1, TSC2
negative regulation of transferase activity (GO:0051348)	3.87	2	IRAK3, TSC2
positive regulation of leukocyte migration (GO:0002687)	5.05	2	THBS4, EDN3
regulation of leukocyte migration (GO:0002685)	4.72	2	THBS4, EDN3
transcription initiation from RNA polymerase II promoter (GO:0006367)	4.7	2	POLR2F, CREBBP
negative regulation of developmental growth (GO:0048640)	5.25	2	PTCH1, SEMA3D
cellular response to biotic stimulus (GO:0071216)	4.76	2	EDNRB, PLAU
neural tube closure (GO:0001843)	5.38	2	PTCH1, TSC2
organic cyclic compound catabolic process (GO:1901361)	3.73	2	DPYD, ZHX2
negative regulation of intracellular signal transduction (GO:1902532)	3.63	2	IRAK3, TSC2
regulation of leukocyte chemotaxis (GO:0002688)	5.17	2	THBS4, EDN3
regulation of tube size (GO:0035150)	4.79	2	EDNRB, EDN3
organ morphogenesis (GO:0009887)	3.55	2	FBN1, PTCH1
single organism cell adhesion (GO:0098602)	3.63	2	THBS4, RET
response to cytokine (GO:0034097)	3.84	2	IRAK3, CREBBP
heterocycle catabolic process (GO:0046700)	3.82	2	DPYD, ZHX2
tube closure (GO:0060606)	5.36	2	PTCH1, TSC2
maintenance of cell number (GO:0098727)	4.82	2	POLR2F, ZHX2
positive regulation of type I interferon production (GO:0032481)	5.48	2	POLR2F, CREBBP
single-organism membrane organization (GO:0044802)	3.19	2	PTCH1, GDNF
somatic stem cell population maintenance (GO:0035019)	5.52	2	POLR2F, ZHX2
nucleobase-containing compound catabolic process (GO:0034655)	3.9	2	DPYD, ZHX2
regulation of neuron death (GO:1901214)	4.19	2	NTF3, GDNF
negative regulation of neuron death (GO:1901215)	4.57	2	NTF3, GDNF
extracellular matrix organization (GO:0030198)	4.01	2	FBN1, KDR
mRNA metabolic process (GO:0016071)	3.33	2	POLR2F, ZHX2
immune response-activating signal transduction (GO:0002757)	3.8	2	IRAK3, CREBBP
cellular nitrogen compound catabolic process (GO:0044270)	3.8	2	DPYD, ZHX2
intracellular transport (GO:0046907)	2.67	2	PTCH1, TSC2
peripheral nervous system development (GO:0007422)	6.47	2	EDNRB, GDNF
response to decreased oxygen levels (GO:0036293)	4.09	2	CREBBP, PLAU
cellular response to nitrogen compound (GO:1901699)	3.79	2	PLAU, FBN1
innate immune response-activating signal transduction (GO:0002758)	4.45	2	IRAK3, CREBBP
regulation of growth (GO:0040008)	3.26	2	PTCH1, SEMA3D
activation of innate immune response (GO:0002218)	4.41	2	IRAK3, CREBBP
regulation of smoothened signaling pathway (GO:0008589)	5.62	2	CREBBP, PTCH1
neuron projection morphogenesis (GO:0048812)	4.34	2	THBS4, NTF3
positive regulation of leukocyte chemotaxis (GO:0002690)	5.35	2	THBS4, EDN3
DNA-templated transcription, initiation (GO:0006352)	4.49	2	POLR2F, CREBBP
regulation of developmental growth (GO:0048638)	4.04	2	PTCH1, SEMA3D
negative regulation of response to external stimulus (GO:0032102)	4.18	2	PLAU, SEMA3D
posterior midgut development (GO:0007497)	9.04	2	EDNRB, RET
ion homeostasis (GO:0050801)	3.42	2	EDN3, EDNRB
establishment of localization in cell (GO:0051649)	2.47	2	PTCH1, TSC2
negative regulation of cellular component organization (GO:0051129)	3.35	2	IRAK3, SEMA3D
modulation of synaptic transmission (GO:0050804)	4.09	2	NTF3, GDNF
cellular catabolic process (GO:0044248)	2.62	2	DPYD, ZHX2
positive regulation of MAP kinase activity (GO:0043406)	4.39	2	EDN3, NTF3
signaling (GO:0023052)	3.25	2	EDN3, NTF3
regulation of secretion by cell (GO:1903530)	3.28	2	EDN3, GDNF
positive regulation of secretion by cell (GO:1903532)	3.93	2	EDN3, GDNF
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	5.26	2	NTF3, RET
response to hypoxia (GO:0001666)	4.13	2	CREBBP, PLAU
protein autophosphorylation (GO:0046777)	4.46	2	IRAK3, KDR
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	EDNRB, EDN3
regulation of blood vessel size (GO:0050880)	4.8	2	EDN3, EDNRB
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	EDN3, EDNRB
regulation of system process (GO:0044057)	3.53	2	EDN3, EDNRB
catabolic process (GO:0009056)	2.38	2	DPYD, ZHX2
regulation of cell cycle process (GO:0010564)	3.5	2	EDN3, CREBBP
positive regulation of neurogenesis (GO:0050769)	3.77	2	NTF3, RET
cellular localization (GO:0051641)	2.32	2	PTCH1, TSC2
cellular response to endogenous stimulus (GO:0071495)	3.33	2	PLAU, FBN1
negative regulation of cell proliferation (GO:0008285)	3.26	2	PTCH1, TSC2
tube morphogenesis (GO:0035239)	4.35	2	PTCH1, GDNF
melanocyte differentiation (GO:0030318)	6.73	2	EDN3, EDNRB
regulation of body fluid levels (GO:0050878)	3.76	2	EDNRB, PLAU
cell proliferation (GO:0008283)	3.23	2	CREBBP, PTCH1
cellular metal ion homeostasis (GO:0006875)	3.75	2	EDN3, EDNRB
neurological system process (GO:0050877)	2.64	2	EDNRB, CNTN5
cellular ion homeostasis (GO:0006873)	3.57	2	EDNRB, EDN3
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	NTF3, TSC2
mesonephric epithelium development (GO:0072163)	5.8	2	RET, GDNF
mesonephric tubule development (GO:0072164)	5.82	2	RET, GDNF
branching morphogenesis of an epithelial tube (GO:0048754)	4.93	2	PTCH1, GDNF
cellular cation homeostasis (GO:0030003)	3.6	2	EDNRB, EDN3
ureteric bud development (GO:0001657)	5.97	2	RET, GDNF
branching involved in ureteric bud morphogenesis (GO:0001658)	5.97	2	PTCH1, GDNF
single organismal cell-cell adhesion (GO:0016337)	3.69	2	THBS4, RET
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	2	KDR, TSC2
cell part morphogenesis (GO:0032990)	3.99	2	THBS4, NTF3
protein oligomerization (GO:0051259)	3.71	2	THBS4, AHNAK
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	IRAK3, PTCH1
regulation of axonogenesis (GO:0050770)	4.59	2	RET, SEMA3D
cellular response to organic cyclic compound (GO:0071407)	3.93	2	PLAU, PTCH1
response to drug (GO:0042493)	3.71	2	RET, PTCH1
regulation of cell-matrix adhesion (GO:0001952)	5.21	2	PLAU, KDR
regulation of metanephros development (GO:0072215)	6.59	2	RET, GDNF
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	CREBBP, GDNF
regulation of type I interferon production (GO:0032479)	5.03	2	POLR2F, CREBBP
positive regulation of protein kinase activity (GO:0045860)	3.61	2	EDN3, NTF3
myeloid leukocyte migration (GO:0097529)	5.13	2	EDNRB, EDN3
positive regulation of cytokine production (GO:0001819)	3.82	2	POLR2F, CREBBP
negative regulation of growth (GO:0045926)	4.24	2	PTCH1, SEMA3D
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	2	NTF3, RET
peptidyl-tyrosine phosphorylation (GO:0018108)	4.48	2	RET, KDR
glucose homeostasis (GO:0042593)	4.6	2	PLAU, PTCH1
regulation of blood pressure (GO:0008217)	4.72	2	EDN3, EDNRB
angiogenesis (GO:0001525)	4.15	2	PLAU, KDR
regulation of cell division (GO:0051302)	4.88	2	THBS4, PTCH1
regulation of ion transport (GO:0043269)	3.4	2	EDN3, AHNAK
morphogenesis of an epithelium (GO:0002009)	4.08	2	PTCH1, GDNF
positive regulation of nervous system development (GO:0051962)	3.64	2	NTF3, RET
response to interleukin-1 (GO:0070555)	5.07	2	IRAK3, CREBBP
regulation of angiogenesis (GO:0045765)	4.36	2	THBS4, KDR
kidney epithelium development (GO:0072073)	5.54	2	RET, GDNF
regulation of cell adhesion mediated by integrin (GO:0033628)	6.04	2	PLAU, RET
regulation of cell maturation (GO:1903429)	6.84	2	EDNRB, RET
extracellular structure organization (GO:0043062)	4.0	2	FBN1, KDR
positive regulation of mitotic cell cycle (GO:0045931)	4.98	2	EDN3, CREBBP
response to retinoic acid (GO:0032526)	5.02	2	RET, PTCH1
negative regulation of protein kinase activity (GO:0006469)	4.29	2	IRAK3, TSC2
positive regulation of innate immune response (GO:0045089)	4.22	2	IRAK3, CREBBP
regulation of innate immune response (GO:0045088)	3.86	2	IRAK3, CREBBP
morphogenesis of a branching epithelium (GO:0061138)	4.77	2	PTCH1, GDNF
regulation of cell-substrate adhesion (GO:0010810)	4.56	2	PLAU, KDR
cellular protein localization (GO:0034613)	3.11	2	PTCH1, TSC2
cation homeostasis (GO:0055080)	3.46	2	EDNRB, EDN3
regulation of metal ion transport (GO:0010959)	3.94	2	EDN3, AHNAK
regulation of neuron maturation (GO:0014041)	7.43	2	EDNRB, RET
metal ion homeostasis (GO:0055065)	3.61	2	EDNRB, EDN3
cell-cell signaling (GO:0007267)	3.35	2	EDN3, NTF3
positive chemotaxis (GO:0050918)	6.17	2	NTF3, TSC2
tube development (GO:0035295)	4.41	2	RET, GDNF
homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	4.68	2	RET, FAT3
regulation of endocytosis (GO:0030100)	4.42	2	NTF3, TSC2
response to oxygen levels (GO:0070482)	4.02	2	CREBBP, PLAU
heart development (GO:0007507)	4.24	2	FBN1, TSC2
cell projection morphogenesis (GO:0048858)	4.05	2	THBS4, NTF3
positive regulation of endothelial cell proliferation (GO:0001938)	5.51	2	THBS4, KDR
regulation of ion homeostasis (GO:2000021)	4.44	2	EDNRB, KDR
regulation of organ morphogenesis (GO:2000027)	4.22	2	PLAU, GDNF
activation of immune response (GO:0002253)	3.67	2	IRAK3, CREBBP
protein transport (GO:0015031)	2.62	2	PTCH1, TSC2
single-organism intracellular transport (GO:1902582)	3.59	2	PTCH1, TSC2
single-organism cellular localization (GO:1902580)	3.16	2	PTCH1, TSC2
cellular response to organonitrogen compound (GO:0071417)	3.87	2	PLAU, FBN1
regulation of endothelial cell proliferation (GO:0001936)	5.14	2	THBS4, KDR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
negative regulation of apoptotic signaling pathway (GO:2001234)	NEW	4.42	0.005	EDNRB, KDR, TSC2, PLAU, FBN1, GDNF, ZHX2
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	-	4.69	0.039	KDR, PLAU, FBN1, GDNF, RET, ZHX2
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	NEW	5.13	0.043	PLAU, FBN1, GDNF, ZHX2, KDR
regulation of secretion (GO:0051046)	-	3.2	0.038	CREBBP, EDNRB, TSC2, KDR, PLAU, PTCH1, EDN3, NTF3, GDNF, RET
regulation of apoptotic signaling pathway (GO:2001233)	-	3.83	0.0	CREBBP, EDNRB, TSC2, KDR, PLAU, FBN1, NTF3, GDNF, RET, ZHX2
regulation of response to stimulus (GO:0048583)	-	1.54	0.006	CREBBP, EDNRB, EDN3, TSC2, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, RET
regulation of positive chemotaxis (GO:0050926)	-	6.55	0.004	NTF3, RET, GDNF, KDR
positive regulation of positive chemotaxis (GO:0050927)	-	6.59	0.003	NTF3, GDNF, RET, KDR
regulation of chemotaxis (GO:0050920)	-	4.53	0.01	THBS4, EDN3, NTF3, KDR
positive regulation of chemotaxis (GO:0050921)	-	4.94	0.003	THBS4, EDN3, NTF3, KDR
enzyme linked receptor protein signaling pathway (GO:0007167)	-	3.24	0.026	CREBBP, EDNRB, TSC2, KDR, PLAU, FBN1, NTF3, GDNF, GFRA1, RET, ZHX2
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	-	3.54	0.001	CREBBP, EDNRB, KDR, TSC2, PLAU, FBN1, NTF3, GDNF, GFRA1, RET, ZHX2
regulation of cell projection organization (GO:0031344)	-	3.38	0.035	CNTN5, KDR, CREBBP, PTCH1, NTF3, FBN1, GDNF, RET, FAT3
response to pain (GO:0048265)	-	6.78	0.008	THBS4, EDNRB, RET
morphogenesis of an epithelium (GO:0002009)	-	4.08	0.019	EDNRB, KDR, RET, PTCH1, FBN1, GDNF, GFRA1, CREBBP
taxis (GO:0042330)	-	4.03	0.011	CREBBP, EDNRB, KDR, TSC2, PLAU, EDN3, NTF3, RET
regulation of signal transduction (GO:0009966)	-	1.84	0.009	CREBBP, EDN3, TSC2, KDR, IRAK3, PLAU, PTCH1, FBN1, NTF3, GDNF, RET
regulation of response to external stimulus (GO:0032101)	-	3.06	0.008	CREBBP, EDNRB, EDN3, TSC2, KDR, PLAU, NTF3, THBS4, GDNF, GFRA1, RET
response to growth factor (GO:0070848)	-	4.14	0.031	CREBBP, KDR, TSC2, PLAU, FBN1, NTF3, GDNF, POLR2F, RET, ZHX2
regulation of neuron differentiation (GO:0045664)	-	3.39	0.0	EDNRB, CNTN5, KDR, RET, CREBBP, PTCH1, NTF3, FBN1, FAT3, GDNF, PLAU, ZHX2
regulation of epithelial cell differentiation (GO:0030856)	-	4.96	0.012	EDNRB, KDR, CREBBP, FBN1, GDNF, RET
epithelial cell differentiation (GO:0030855)	NEW	3.98	0.002	EDNRB, KDR, RET, CREBBP, PTCH1, FBN1, EDN3, GDNF, NTF3
negative regulation of biological process (GO:0048519)	-	1.33	0.038	EDNRB, TSC2, KDR, IRAK3, PLAU, PTCH1, FBN1, NTF3, THBS4, GDNF, CREBBP, ZHX2, FAT3
chemotaxis (GO:0006935)	-	4.04	0.011	EDNRB, KDR, TSC2, RET, CREBBP, EDN3, NTF3, PLAU
phasic smooth muscle contraction (GO:0014821)	-	6.96	0.014	EDNRB, EDN3, GDNF
smooth muscle contraction (GO:0006939)	-	5.9	0.021	EDN3, EDNRB, GDNF
pigment cell differentiation (GO:0050931)	-	6.64	0.039	CREBBP, EDNRB, EDN3
induction of positive chemotaxis (GO:0050930)	NEW	7.24	0.022	NTF3, RET, GDNF
vein smooth muscle contraction (GO:0014826)	-	8.34	0.008	EDN3, EDNRB
regulation of neuron projection development (GO:0010975)	-	3.69	0.004	CNTN5, KDR, RET, PTCH1, FBN1, NTF3, GDNF, CREBBP, FAT3
neural crest cell migration (GO:0001755)	-	5.76	0.012	EDNRB, EDN3, GDNF, RET
cellular response to growth factor stimulus (GO:0071363)	-	4.27	0.021	KDR, TSC2, RET, CREBBP, NTF3, FBN1, GDNF, POLR2F, PLAU, ZHX2
neuron projection guidance (GO:0097485)	NEW	4.43	0.001	CNTN5, KDR, IRAK3, RET, PTCH1, FBN1, NTF3, GDNF, GFRA1, CREBBP
single organism signaling (GO:0044700)	-	3.25	0.002	EDNRB, EDN3, CNTN5, KDR, RET, PTCH1, FBN1, NTF3, GDNF, POLR2F, CREBBP, ZHX2
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.001	EDNRB, EDN3, KDR, TSC2, RET, CREBBP, PTCH1, FBN1, NTF3, THBS4, GDNF, PLAU, ZHX2
single-multicellular organism process (GO:0044707)	-	1.78	0.034	EDNRB, CNTN5, KDR, CREBBP, PTCH1, EDN3, PLAU, THBS4, FAT3, GDNF, RET, ZHX2
cell motility (GO:0048870)	-	3.02	0.0	CREBBP, EDNRB, EDN3, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, ZHX2, GDNF, GFRA1, RET, FAT3
muscle system process (GO:0003012)	-	4.18	0.003	EDNRB, CNTN5, KDR, PLAU, FBN1, EDN3, GDNF, RET
circulatory system process (GO:0003013)	-	4.38	0.001	EDNRB, KDR, RET, FBN1, EDN3, POLR2F, CREBBP
muscle cell differentiation (GO:0042692)	NEW	5.09	0.006	EDNRB, KDR, CREBBP, PTCH1, NTF3, PLAU
regulation of cell morphogenesis (GO:0022604)	-	3.4	0.004	CREBBP, EDNRB, TSC2, KDR, PLAU, PTCH1, FBN1, NTF3, GDNF, RET
regulation of anatomical structure morphogenesis (GO:0022603)	-	2.79	0.011	CREBBP, EDNRB, KDR, TSC2, PLAU, PTCH1, FBN1, NTF3, THBS4, GDNF, POLR2F, RET
cell differentiation involved in kidney development (GO:0061005)	NEW	6.64	0.003	CREBBP, PTCH1, RET, GDNF
cellular component movement (GO:0006928)	-	2.61	0.001	EDNRB, EDN3, KDR, RET, THBS4, NTF3, GDNF, GFRA1, PLAU, FAT3
enteric nervous system development (GO:0048484)	-	7.33	0.0	EDNRB, NTF3, GDNF, RET
sympathetic nervous system development (GO:0048485)	NEW	6.96	0.021	CREBBP, RET, GDNF
neuron projection development (GO:0031175)	NEW	4.58	0.039	CNTN5, KDR, CREBBP, FBN1, GDNF, RET
cell morphogenesis involved in differentiation (GO:0000904)	NEW	4.67	0.002	EDNRB, KDR, RET, FBN1, GDNF, CREBBP, FAT3
positive regulation of transferase activity (GO:0051347)	-	3.31	0.028	KDR, TSC2, RET, CREBBP, PTCH1, EDN3, NTF3, GDNF, PLAU, ZHX2
cell morphogenesis (GO:0000902)	NEW	4.35	0.02	EDNRB, KDR, CREBBP, FBN1, GDNF, RET, FAT3
regulation of kinase activity (GO:0043549)	-	3.07	0.004	CREBBP, EDNRB, TSC2, KDR, IRAK3, PLAU, PTCH1, EDN3, NTF3, GDNF, RET, ZHX2
blood circulation (GO:0008015)	NEW	5.97	0.001	CREBBP, EDN3, FBN1, POLR2F, KDR
cell migration (GO:0016477)	-	3.12	0.0	CREBBP, EDNRB, EDN3, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, ZHX2, GDNF, GFRA1, RET, FAT3
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.001	CREBBP, EDNRB, CNTN5, KDR, TSC2, PLAU, PTCH1, FBN1, THBS4, GDNF, POLR2F, RET, FAT3
positive regulation of cellular component organization (GO:0051130)	-	2.68	0.01	CREBBP, EDNRB, EDN3, CNTN5, KDR, PLAU, PTCH1, FBN1, NTF3, GDNF, RET, ZHX2
regulation of developmental process (GO:0050793)	-	2.1	0.0	EDNRB, EDN3, KDR, IRAK3, RET, PTCH1, THBS4, NTF3, ZHX2, GDNF, CREBBP, FAT3
regulation of behavior (GO:0050795)	NEW	5.55	0.038	THBS4, EDN3, NTF3, KDR
positive regulation of MAPK cascade (GO:0043410)	-	3.57	0.049	EDNRB, KDR, PLAU, PTCH1, EDN3, NTF3, FBN1, CREBBP
single-organism membrane organization (GO:0044802)	-	3.19	0.042	CNTN5, KDR, AHNAK, PLAU, PTCH1, FBN1, GDNF, RET
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.0	EDNRB, EDN3, KDR, RET, IRAK3, CREBBP, PTCH1, NTF3, THBS4, FAT3, GDNF, POLR2F, PLAU, ZHX2
regulation of ossification (GO:0030278)	NEW	4.53	0.006	KDR, CREBBP, PTCH1, FBN1, GDNF, GFRA1, ZHX2
negative regulation of ossification (GO:0030279)	NEW	5.48	0.0	CREBBP, RET, FBN1, GDNF, KDR
secretion (GO:0046903)	NEW	3.38	0.016	EDNRB, TSC2, KDR, PLAU, PTCH1, EDN3, NTF3, FBN1, POLR2F, CREBBP
negative regulation of signal transduction (GO:0009968)	-	2.75	0.036	CREBBP, EDNRB, TSC2, KDR, IRAK3, PLAU, PTCH1, FBN1, NTF3, GDNF, RET, ZHX2
peripheral nervous system development (GO:0007422)	-	6.47	0.0	CREBBP, RET, GDNF, NTF3, EDNRB
positive regulation of protein modification process (GO:0031401)	-	2.7	0.019	EDNRB, EDN3, KDR, TSC2, RET, CREBBP, PTCH1, NTF3, THBS4, GDNF, PLAU, ZHX2
regulation of transferase activity (GO:0051338)	-	2.88	0.001	EDNRB, KDR, TSC2, RET, IRAK3, CREBBP, PTCH1, EDN3, NTF3, GDNF, POLR2F, PLAU, ZHX2
regulation of nervous system development (GO:0051960)	-	3.1	0.002	CREBBP, EDNRB, CNTN5, KDR, PLAU, PTCH1, FBN1, NTF3, ZHX2, GDNF, RET, FAT3
regulation of cell motility (GO:2000145)	-	3.16	0.004	CREBBP, EDN3, TSC2, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, RET
positive regulation of cell motility (GO:2000147)	-	3.74	0.016	CREBBP, KDR, PLAU, NTF3, EDN3, THBS4, GDNF, RET
positive regulation of kinase activity (GO:0033674)	-	3.54	0.008	CREBBP, TSC2, KDR, PLAU, PTCH1, EDN3, NTF3, GDNF, RET, ZHX2
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.003	CREBBP, EDNRB, EDN3, TSC2, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, RET, ZHX2
posterior midgut development (GO:0007497)	-	9.04	0.009	EDNRB, RET
tube formation (GO:0035148)	-	4.98	0.009	RET, PTCH1, GDNF, TSC2
cell-cell signaling (GO:0007267)	-	3.35	0.001	EDNRB, EDN3, CNTN5, KDR, RET, PTCH1, FBN1, NTF3, GDNF, POLR2F, CREBBP, ZHX2
signaling (GO:0023052)	-	3.25	0.002	EDNRB, EDN3, CNTN5, KDR, RET, PTCH1, FBN1, NTF3, GDNF, POLR2F, CREBBP, ZHX2
regulation of signaling (GO:0023051)	-	1.72	0.029	CREBBP, EDN3, TSC2, KDR, IRAK3, PLAU, PTCH1, FBN1, NTF3, GDNF, RET
axon guidance (GO:0007411)	NEW	4.44	0.001	CNTN5, KDR, IRAK3, RET, PTCH1, FBN1, NTF3, GDNF, GFRA1, CREBBP
ameboidal cell migration (GO:0001667)	-	4.71	0.0	EDNRB, KDR, CREBBP, EDN3, GDNF, GFRA1, RET
regulation of cell communication (GO:0010646)	-	1.73	0.031	CREBBP, EDN3, TSC2, KDR, IRAK3, PLAU, PTCH1, FBN1, NTF3, GDNF, RET
regulation of MAPK cascade (GO:0043408)	-	3.22	0.0	EDNRB, EDN3, KDR, TSC2, RET, IRAK3, CREBBP, PTCH1, FBN1, NTF3, PLAU, ZHX2
regulation of neurogenesis (GO:0050767)	-	3.21	0.001	CREBBP, EDNRB, CNTN5, KDR, RET, PTCH1, FBN1, NTF3, FAT3, GDNF, PLAU, ZHX2
positive regulation of multicellular organismal process (GO:0051240)	-	2.49	0.047	EDNRB, EDN3, KDR, RET, CREBBP, PTCH1, NTF3, FBN1, GDNF, POLR2F, PLAU
negative regulation of multicellular organismal process (GO:0051241)	-	2.84	0.026	EDNRB, KDR, IRAK3, CREBBP, PTCH1, FBN1, GDNF, GFRA1, PLAU
regulation of cell development (GO:0060284)	-	3.01	0.0	CREBBP, EDNRB, CNTN5, KDR, TSC2, IRAK3, RET, PTCH1, FBN1, NTF3, FAT3, GDNF, PLAU, ZHX2
regulation of cell morphogenesis involved in differentiation (GO:0010769)	-	3.91	0.0	CREBBP, EDNRB, TSC2, KDR, PLAU, PTCH1, FBN1, NTF3, GDNF, RET
lymphocyte migration into lymphoid organs (GO:0097021)	NEW	8.63	0.029	RET, GDNF
neuroepithelial cell differentiation (GO:0060563)	NEW	6.51	0.007	CREBBP, EDN3, EDNRB, GDNF
biological adhesion (GO:0022610)	-	2.81	0.043	CREBBP, EDNRB, CNTN5, KDR, TSC2, PLAU, THBS4, FBN1, SEMA3D, RET, FAT3
regulation of stem cell proliferation (GO:0072091)	NEW	5.6	0.034	CREBBP, FBN1, PTCH1, GDNF, KDR
multicellular organismal process (GO:0032501)	-	1.45	0.043	EDNRB, CNTN5, KDR, RET, PTCH1, EDN3, PLAU, THBS4, FAT3, GDNF, CREBBP, ZHX2
melanocyte differentiation (GO:0030318)	-	6.73	0.033	CREBBP, EDN3, EDNRB
positive regulation of cellular component movement (GO:0051272)	-	3.71	0.017	CREBBP, KDR, PLAU, NTF3, EDN3, THBS4, GDNF, RET
cellular response to lipid (GO:0071396)	-	3.96	0.023	EDNRB, KDR, RET, CREBBP, PTCH1, NTF3, GDNF, PLAU
negative regulation of cell differentiation (GO:0045596)	-	3.33	0.008	EDNRB, KDR, TSC2, CREBBP, PTCH1, NTF3, FBN1, GDNF, POLR2F, RET, ZHX2
regulation of cell differentiation (GO:0045595)	-	2.42	0.006	EDNRB, KDR, RET, PTCH1, NTF3, FAT3, GDNF, CREBBP, ZHX2
regulation of cellular component movement (GO:0051270)	-	3.08	0.008	CREBBP, EDN3, TSC2, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, RET
regulation of localization (GO:0032879)	-	1.94	0.002	EDNRB, EDN3, TSC2, AHNAK, PLAU, PTCH1, NTF3, THBS4, GDNF, KDR, RET
negative regulation of developmental process (GO:0051093)	-	3.17	0.001	EDNRB, TSC2, KDR, ZHX2, RET, PTCH1, FBN1, NTF3, THBS4, GDNF, POLR2F, CREBBP, FAT3
negative regulation of cellular protein metabolic process (GO:0032269)	-	2.88	0.012	EDNRB, KDR, TSC2, RET, IRAK3, CREBBP, NTF3, GDNF, POLR2F, PLAU
regulation of epithelial cell proliferation (GO:0050678)	-	4.06	0.01	THBS4, PTCH1, EDNRB, TSC2, KDR
positive regulation of locomotion (GO:0040017)	-	3.71	0.002	CREBBP, EDN3, KDR, PLAU, NTF3, THBS4, GDNF, GFRA1, RET
system development (GO:0048731)	-	2.92	0.001	CREBBP, EDNRB, CNTN5, GDNF, KDR, PLAU, PTCH1, FBN1, POLR2F, NTF3, SEMA3D, GFRA1, RET
positive regulation of protein kinase activity (GO:0045860)	-	3.61	0.006	KDR, TSC2, RET, CREBBP, PTCH1, EDN3, NTF3, GDNF, PLAU, ZHX2
cell projection organization (GO:0030030)	-	3.14	0.012	EDNRB, CNTN5, KDR, TSC2, CREBBP, PTCH1, FBN1, GDNF, GFRA1, POLR2F, RET
leukocyte migration (GO:0050900)	-	4.19	0.0	EDNRB, KDR, RET, CREBBP, EDN3, GDNF, GFRA1, PLAU
smooth muscle cell differentiation (GO:0051145)	NEW	6.68	0.003	CREBBP, EDNRB, NTF3, KDR
pattern specification process (GO:0007389)	NEW	3.79	0.002	CREBBP, GDNF, TSC2, KDR, PLAU, PTCH1, FBN1, SEMA3D, POLR2F, RET
cell proliferation (GO:0008283)	-	3.23	0.03	CREBBP, EDNRB, TSC2, KDR, PLAU, PTCH1, FBN1, GDNF, POLR2F, GFRA1, ZHX2
tissue morphogenesis (GO:0048729)	-	3.87	0.007	EDNRB, KDR, CREBBP, PTCH1, NTF3, FBN1, GDNF, GFRA1, RET
positive regulation of cell migration (GO:0030335)	-	3.77	0.014	EDN3, KDR, RET, CREBBP, NTF3, THBS4, GDNF, PLAU
regulation of protein kinase activity (GO:0045859)	-	3.15	0.002	CREBBP, EDNRB, TSC2, KDR, IRAK3, PLAU, PTCH1, EDN3, NTF3, GDNF, RET, ZHX2
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.003	CREBBP, EDNRB, EDN3, KDR, TSC2, PLAU, PTCH1, FBN1, NTF3, THBS4, GDNF, RET, ZHX2
morphogenesis of a branching epithelium (GO:0061138)	-	4.77	0.043	KDR, CREBBP, PTCH1, GDNF, GFRA1, RET
regulation of cell migration (GO:0030334)	-	3.23	0.02	CREBBP, EDN3, TSC2, KDR, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, RET
regulation of neuron maturation (GO:0014041)	-	7.43	0.03	EDNRB, RET
cell adhesion (GO:0007155)	-	2.82	0.042	CREBBP, EDNRB, CNTN5, TSC2, KDR, RET, FBN1, THBS4, SEMA3D, PLAU, FAT3
cell communication (GO:0007154)	-	3.04	0.002	EDNRB, EDN3, CNTN5, TSC2, KDR, RET, PTCH1, FBN1, NTF3, GDNF, POLR2F, CREBBP, ZHX2
locomotion (GO:0040011)	-	2.91	0.0	CREBBP, EDNRB, EDN3, CNTN5, KDR, TSC2, PLAU, PTCH1, FBN1, NTF3, THBS4, GDNF, GFRA1, RET, ZHX2, FAT3
heart development (GO:0007507)	-	4.24	0.005	KDR, TSC2, PLAU, PTCH1, FBN1, POLR2F, CREBBP
regulation of locomotion (GO:0040012)	-	3.12	0.001	CREBBP, EDN3, TSC2, KDR, PLAU, PTCH1, FBN1, NTF3, THBS4, GDNF, GFRA1, RET
nervous system development (GO:0007399)	-	3.53	0.0	EDNRB, CNTN5, SEMA3D, RET, PTCH1, FBN1, NTF3, GDNF, GFRA1, CREBBP
cellular response to hormone stimulus (GO:0032870)	NEW	3.99	0.033	KDR, TSC2, RET, CREBBP, NTF3, GDNF, POLR2F, PLAU, ZHX2
positive regulation of behavior (GO:0048520)	NEW	6.47	0.007	THBS4, EDN3, NTF3, KDR
regulation of multicellular organismal development (GO:2000026)	-	2.31	0.009	EDNRB, KDR, IRAK3, RET, THBS4, NTF3, ZHX2, GDNF, FAT3
regulation of organ morphogenesis (GO:2000027)	-	4.22	0.042	KDR, CREBBP, PTCH1, NTF3, FBN1, GDNF
regulation of protein phosphorylation (GO:0001932)	-	2.57	0.001	CREBBP, EDNRB, EDN3, TSC2, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, GDNF, RET, ZHX2
positive regulation of protein phosphorylation (GO:0001934)	-	2.95	0.002	EDNRB, EDN3, KDR, TSC2, RET, CREBBP, PTCH1, THBS4, NTF3, GDNF, PLAU, ZHX2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	19	THBS4, CREBBP, EDNRB, EDN3, CNTN5, TSC2, AHNAK, IRAK3, PLAU, PTCH1, DPYD, NTF3, FAT3, GDNF, KDR, GFRA1, POLR2F, RET, ZHX2
intracellular part (GO:0044424)	0.28	14	EDNRB, CNTN5, AHNAK, TSC2, IRAK3, RET, PTCH1, NTF3, THBS4, DPYD, KDR, POLR2F, CREBBP, ZHX2
membrane-bounded organelle (GO:0043227)	0.47	14	CREBBP, AHNAK, TSC2, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, KDR, GFRA1, POLR2F, RET, ZHX2
organelle (GO:0043226)	0.4	14	CREBBP, AHNAK, TSC2, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, KDR, GFRA1, POLR2F, RET, ZHX2
membrane (GO:0016020)	0.68	12	EDNRB, CNTN5, TSC2, AHNAK, PLAU, PTCH1, FAT3, SEMA3D, KDR, GFRA1, RET, ZHX2
intracellular organelle (GO:0043229)	0.51	11	AHNAK, TSC2, IRAK3, CREBBP, PTCH1, THBS4, NTF3, KDR, POLR2F, RET, ZHX2
intracellular membrane-bounded organelle (GO:0043231)	0.6	11	AHNAK, TSC2, IRAK3, CREBBP, PTCH1, THBS4, NTF3, KDR, POLR2F, RET, ZHX2
cytoplasmic part (GO:0044444)	0.82	10	EDNRB, AHNAK, TSC2, RET, PTCH1, NTF3, THBS4, DPYD, KDR, POLR2F
plasma membrane (GO:0005886)	1.39	10	EDNRB, CNTN5, KDR, AHNAK, RET, PTCH1, FAT3, GFRA1, PLAU, ZHX2
cytoplasm (GO:0005737)	1.01	9	TSC2, CNTN5, AHNAK, KDR, IRAK3, RET, DPYD, CREBBP, ZHX2
membrane part (GO:0044425)	0.95	9	EDNRB, CNTN5, KDR, AHNAK, RET, PTCH1, SEMA3D, GFRA1, FAT3
extracellular region (GO:0005576)	2.18	8	EDN3, SEMA3D, KDR, PLAU, FBN1, NTF3, THBS4, GDNF
intrinsic component of membrane (GO:0031224)	1.13	8	EDNRB, CNTN5, KDR, RET, PTCH1, SEMA3D, GFRA1, FAT3
vesicle (GO:0031982)	1.64	7	KDR, AHNAK, PLAU, FBN1, NTF3, THBS4, GFRA1
nucleus (GO:0005634)	1.07	7	AHNAK, TSC2, IRAK3, CREBBP, KDR, POLR2F, ZHX2
membrane-bounded vesicle (GO:0031988)	1.71	7	KDR, AHNAK, PLAU, FBN1, NTF3, THBS4, GFRA1
intracellular organelle part (GO:0044446)	0.81	7	EDNRB, AHNAK, RET, PTCH1, POLR2F, CREBBP, ZHX2
extracellular region part (GO:0044421)	1.57	7	AHNAK, PLAU, EDN3, THBS4, FBN1, SEMA3D, GFRA1
organelle part (GO:0044422)	0.79	7	EDNRB, AHNAK, RET, PTCH1, POLR2F, CREBBP, ZHX2
integral component of membrane (GO:0016021)	1.14	6	EDNRB, KDR, RET, PTCH1, SEMA3D, FAT3
extracellular vesicle (GO:1903561)	1.89	5	THBS4, PLAU, FBN1, GFRA1, AHNAK
extracellular organelle (GO:0043230)	1.89	5	GFRA1, PLAU, FBN1, THBS4, AHNAK
extracellular space (GO:0005615)	2.63	5	EDN3, PLAU, FBN1, THBS4, SEMA3D
cytosol (GO:0005829)	1.68	5	EDNRB, POLR2F, DPYD, TSC2, AHNAK
membrane region (GO:0098589)	3.95	5	EDNRB, PTCH1, RET, KDR, AHNAK
membrane raft (GO:0045121)	4.18	5	EDNRB, PTCH1, KDR, AHNAK, RET
membrane microdomain (GO:0098857)	4.17	5	EDNRB, PTCH1, RET, KDR, AHNAK
plasma membrane part (GO:0044459)	1.95	5	EDNRB, PTCH1, RET, AHNAK, KDR
extracellular exosome (GO:0070062)	1.89	5	THBS4, PLAU, FBN1, GFRA1, AHNAK
protein complex (GO:0043234)	1.51	4	POLR2F, CREBBP, TSC2, RET
macromolecular complex (GO:0032991)	1.35	4	POLR2F, CREBBP, TSC2, RET
nuclear part (GO:0044428)	1.55	4	CREBBP, EDNRB, POLR2F, ZHX2
organelle membrane (GO:0031090)	1.97	4	EDNRB, PTCH1, RET, AHNAK
Golgi apparatus (GO:0005794)	2.7	3	PTCH1, KDR, TSC2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	3	POLR2F, PTCH1, AHNAK
vacuole (GO:0005773)	2.92	3	RET, KDR, TSC2
bounding membrane of organelle (GO:0098588)	2.39	3	RET, PTCH1, AHNAK
intracellular (GO:0005622)	2.37	3	EDN3, GFRA1, GDNF
nucleoplasm (GO:0005654)	1.89	3	POLR2F, CREBBP, ZHX2
non-membrane-bounded organelle (GO:0043228)	1.76	3	POLR2F, PTCH1, AHNAK
integral component of plasma membrane (GO:0005887)	2.57	3	EDNRB, RET, KDR
intrinsic component of plasma membrane (GO:0031226)	2.53	3	EDNRB, RET, KDR
whole membrane (GO:0098805)	2.85	3	RET, PTCH1, AHNAK
cell junction (GO:0030054)	2.75	3	PLAU, KDR, AHNAK
endoplasmic reticulum (GO:0005783)	2.56	2	THBS4, KDR
extracellular matrix (GO:0031012)	3.81	2	THBS4, FBN1
cell-substrate adherens junction (GO:0005924)	3.83	2	PLAU, AHNAK
focal adhesion (GO:0005925)	3.83	2	PLAU, AHNAK
cell-substrate junction (GO:0030055)	3.82	2	PLAU, AHNAK
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	NTF3, KDR
cytoplasmic vesicle (GO:0031410)	2.87	2	NTF3, KDR
vacuolar membrane (GO:0005774)	3.45	2	RET, AHNAK
neuron part (GO:0097458)	2.64	2	RET, PTCH1
vacuolar part (GO:0044437)	3.26	2	RET, AHNAK
nucleoplasm part (GO:0044451)	3.22	2	POLR2F, CREBBP
perinuclear region of cytoplasm (GO:0048471)	3.35	2	PTCH1, TSC2
anchored component of membrane (GO:0031225)	4.77	2	GFRA1, CNTN5
catalytic complex (GO:1902494)	2.9	2	POLR2F, CREBBP
anchoring junction (GO:0070161)	3.61	2	PLAU, AHNAK
adherens junction (GO:0005912)	3.66	2	PLAU, AHNAK
transferase complex (GO:1990234)	3.32	2	POLR2F, CREBBP
cell projection (GO:0042995)	2.47	2	RET, PTCH1
basement membrane (GO:0005604)	5.34	2	THBS4, FBN1
endosome (GO:0005768)	3.25	2	RET, KDR
early endosome (GO:0005769)	4.34	2	RET, KDR
extracellular matrix component (GO:0044420)	4.97	2	THBS4, FBN1
proteinaceous extracellular matrix (GO:0005578)	4.01	2	THBS4, FBN1
intracellular vesicle (GO:0097708)	2.86	2	NTF3, KDR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
membrane raft (GO:0045121)	-	4.18	0.0	EDNRB, KDR, TSC2, RET, PTCH1, FBN1
extracellular space (GO:0005615)	-	2.63	0.002	CREBBP, EDNRB, EDN3, TSC2, KDR, PLAU, PTCH1, FBN1, NTF3, THBS4, GDNF, GFRA1, RET
membrane region (GO:0098589)	-	3.95	0.021	CREBBP, EDNRB, CNTN5, KDR, TSC2, PLAU, PTCH1, FBN1, NTF3, POLR2F, RET, ZHX2
axon (GO:0030424)	NEW	4.15	0.008	EDNRB, KDR, CREBBP, GDNF, GFRA1, RET
neuron part (GO:0097458)	-	2.64	0.0	CREBBP, EDNRB, CNTN5, TSC2, KDR, RET, PTCH1, FBN1, NTF3, FAT3, GDNF, GFRA1, POLR2F, ZHX2
extracellular region (GO:0005576)	-	2.18	0.0	CREBBP, EDNRB, EDN3, CNTN5, GDNF, KDR, IRAK3, PLAU, PTCH1, NTF3, THBS4, FBN1, SEMA3D, GFRA1, RET
neuron projection (GO:0043005)	NEW	3.12	0.0	EDNRB, CNTN5, TSC2, KDR, RET, NTF3, FAT3, GDNF, GFRA1, CREBBP, ZHX2
cell projection (GO:0042995)	-	2.47	0.0	TSC2, CREBBP, EDNRB, CNTN5, KDR, AHNAK, RET, PTCH1, FBN1, NTF3, FAT3, GDNF, POLR2F, GFRA1, ZHX2