Disease ID | Disease name | Source of annotation with FGD1 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS309510 | MENTAL RETARDATION, X-LINKED SYNDROMIC | ClinVar, OMIM, HUMSAVAR | link to OMIM | 27 | AP1S2, PRPS1, IGBP1, RBMX, HUWE1, RAB40AL, HSD17B10, ATP6AP2, PHF8, CLIC2, CASK, TAF1, FGD1, CUL4B, PQBP1, ZDHHC9, NONO, UPF3B, SMS, HDAC8, UBE2A, MECP2, KDM5C, ARX, SLC9A6, GRIA3, PHF6 |
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KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Regulation of actin cytoskeleton | hsa04810 | 4.9 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
p75 NTR receptor-mediated signalling | R-HSA-193704 | 6.59 |
Signalling by NGF | R-HSA-166520 | 4.23 |
G alpha (12/13) signalling events | R-HSA-416482 | 6.75 |
GPCR downstream signaling | R-HSA-388396 | 3.07 |
Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
Rho GTPase cycle | R-HSA-194840 | 6.04 |
Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 7.05 |
Signaling by GPCR | R-HSA-372790 | 2.68 |
Signal Transduction | R-HSA-162582 | 1.78 |
NRAGE signals death through JNK | R-HSA-193648 | 7.49 |
GO term | GO ID | GO IC |
---|---|---|
Rho guanyl-nucleotide exchange factor activity | GO:0005089 | 5.37 |
Ras guanyl-nucleotide exchange factor activity | GO:0005088 | 4.31 |
metal ion binding | GO:0046872 | 1.41 |
cation binding | GO:0043169 | 1.4 |
guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
enzyme binding | GO:0019899 | 2.27 |
ion binding | GO:0043167 | 1.36 |
small GTPase binding | GO:0031267 | 4.13 |
GTPase binding | GO:0051020 | 4.05 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |
molecular function regulator | GO:0098772 | 2.51 |